CN107496448A - A kind of Povidone Iodine Disinfection Solution and preparation method thereof - Google Patents
A kind of Povidone Iodine Disinfection Solution and preparation method thereof Download PDFInfo
- Publication number
- CN107496448A CN107496448A CN201710918393.8A CN201710918393A CN107496448A CN 107496448 A CN107496448 A CN 107496448A CN 201710918393 A CN201710918393 A CN 201710918393A CN 107496448 A CN107496448 A CN 107496448A
- Authority
- CN
- China
- Prior art keywords
- parts
- povidone iodine
- disinfection solution
- deionized water
- iodine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of Povidone Iodine Disinfection Solution, its raw material includes by weight：0.45 0.8 parts of iodine, 1.5 2.5 parts of polyvinylpyrrolidone, 35 parts of NPE, 80 100 parts of deionized water；The invention also discloses a kind of preparation method of Povidone Iodine Disinfection Solution, comprise the following steps：Deionized water stirring and dissolving is added in polyvinylpyrrolidone, is stirred 46 minutes, it is standby that polyvinylpyrrolidonesolution solution is made；Under normal temperature, condition of normal pressure, iodine is added in S1 in obtained polyvinylpyrrolidonesolution solution, stirred 23 hours, adds NPE, stirs 9 11 hours, adds deionized water, stirs 20 45 minutes, obtains Povidone Iodine Disinfection Solution.Povidone Iodine Disinfection Solution produced by the present invention has the characteristics that Disinfection Effect is good, easy to use, stability is strong, non-stimulated to skin.
Description
Technical field
The present invention relates to disinfectant preparation field, more particularly to a kind of Povidone Iodine Disinfection Solution and preparation method thereof.
Background technology
PVP-I（PVP-I）It is current most important skin antiseptic containing iodine, is the iodophor disinfectant researched and developed earliest, mesh
The NFs such as the preceding loaded U.S., Britain, China.PVP-I is using high molecular polymer --- and polyvinylpyrrolidone is load
Body complexing forms, and is sterilized by discharging free-iodine, carrier is small to Skin and mucosa irritation in itself without sterilizing function, is mainly used in
Human body skin sterilizes and medical apparatus sterilizing, is unsuitable for environment disinfected.
PVP-I prepares and typically prepares solid pharmaceutical preparation first, and when actually using product, then liquid preparation is made.
PVP-I solid product is a kind of amorphous powder of yellowish-brown to rufous, and the easy moisture absorption is not easy to maintain into magma shape, solid
During liquid preparation is made in body preparation, its active ingredient is difficult to keep stable, plays lasting Disinfection Effect.And with
During Betagen Solution processed, addition ethanol, glycerine etc. is often needed to be used as wetting agent, and introduce buffer system with stablizing solution
PH value, improve the stability of solution.Although can improve the stability of PVP-I using organic alcohols, Organic Alcohol adds
The permeability of skin so that iodine strengthens the permeability of skin and causes negative effect.
The content of the invention
Based on technical problem existing for background technology, the present invention proposes a kind of Povidone Iodine Disinfection Solution and its preparation side
Method, Povidone Iodine Disinfection Solution produced by the present invention have that Disinfection Effect is good, easy to use, stability is strong, non-stimulated etc. to skin
Feature.
The present invention provides a kind of Povidone Iodine Disinfection Solution, and its raw material includes by weight：Iodine 0.45-0.8 parts, polyethylene pyrrole
Pyrrolidone 1.5-2.5 parts, NPE 3-5 parts, deionized water 80-100 parts.
Preferably, its raw material includes by weight：Iodine 0.5-0.7 parts, polyvinylpyrrolidone 1.8-2.3 parts, nonyl phenol
APEO 3.8-4.1 parts, deionized water 90-95 parts.
Preferably, its raw material includes by weight：0.58 part of iodine, 2.1 parts of polyvinylpyrrolidone, NPE
3.94 parts, 93.43 parts of deionized water.
Preferably, polyvinylpyrrolidone PVP-K30, pharmaceutical grade, purity >=99.5%.
Preferably, NPE TX-10, purity >=99.9%.
Preferably, iodine uses pharmaceutical grade iodine, purity >=99.5.
The present invention also provides a kind of preparation method of Povidone Iodine Disinfection Solution, comprises the following steps：
S1, deionized water stirring and dissolving is added in polyvinylpyrrolidone, stir 4-6 minutes, polyvinylpyrrolidone is made
Solution for standby；
S2, under normal temperature, condition of normal pressure, iodine is added in S1 in obtained polyvinylpyrrolidonesolution solution, stirs 2-3 hours,
NPE is added, stirs 9-11 hour, adds deionized water, 20-45 minutes is stirred, obtains PVP-I
Thimerosal.
Preferably, the weight of polyvinylpyrrolidone and deionized water ratio is 1 in S1:1.1.
Povidone Iodine Disinfection Solution provided by the invention can kill pathogenic entero becteria, pyococcus and pathogenic yeasts
Bacterium, suitable for being washed one's hands before sanitary washing sterilization, surgery, skin of infusing, injection site skin, minor cut or wound surface of a wound sterilize.
PVP is made using the complexing between iodine, polyvinylpyrrolidone, NPE in the present invention
Iodic disinfecting liquid, products obtained therefrom are liquid preparation, eliminate the easy deliquescence of solid pharmaceutical preparation, it is inconvenient for use the shortcomings that；Gained PVP-I
Thimerosal stable performance, long shelf-life, and without organic alcohols such as ethanol, glycerine, do not interfere with cutaneous permeability, avoid
Negative effect of the iodine to human body.
Embodiment
Below, technical scheme is described in detail by specific embodiment.
Embodiment 1
The invention provides a kind of Povidone Iodine Disinfection Solution, its raw material includes by weight：0.58 part of iodine, polyvinylpyrrolidone
（PVP-K30）2.1 parts, NPE（TX-10）3.94 parts, 93.43 parts of deionized water.
Embodiment 2
The invention provides a kind of Povidone Iodine Disinfection Solution, its raw material includes by weight：0.52 part of iodine, polyvinylpyrrolidone
（PVP-K30）1.9 parts, NPE（TX-10）4.06 parts, 91.4 parts of deionized water.
Embodiment 3
The invention provides a kind of Povidone Iodine Disinfection Solution, its raw material includes by weight：0.67 part of iodine, polyvinylpyrrolidone
（PVP-K30）2.2 parts, NPE（TX-10）3.83 parts, 94.89 parts of deionized water.
Embodiment 4
The invention provides a kind of Povidone Iodine Disinfection Solution, its raw material includes by weight：0.54 part of iodine, polyvinylpyrrolidone
（PVP-K30）2.17 parts, NPE（TX-10）3.98 parts, 92.62 parts of deionized water.
Embodiment 5
The invention provides a kind of Povidone Iodine Disinfection Solution, its raw material includes by weight：0.76 part of iodine, polyvinylpyrrolidone
（PVP-K30）1.6 parts, NPE（TX-10）4.88 parts, 98.62 parts of deionized water.
Embodiment 6
The invention provides a kind of Povidone Iodine Disinfection Solution, its raw material includes by weight：0.46 part of iodine, polyvinylpyrrolidone
（PVP-K30）2.4 parts, NPE（TX-10）3.2 parts, 83.11 parts of deionized water.
Embodiment 7
The invention provides a kind of preparation method of Povidone Iodine Disinfection Solution, comprise the following steps：
S1,2.2 parts of deionized water stirring and dissolvings are added in 2.0 parts of polyvinylpyrrolidones, stirred 5 minutes, polyethylene is made
Pyrrolidone solution is standby；
S2, under normal temperature, condition of normal pressure, 0.54 part of iodine is added in S1 in obtained polyvinylpyrrolidonesolution solution, stirring 2.4
Hour, 3.91 parts of NPEs are added, stir 9.8 hours, add 91.35 deionized waters, stir 28 points
Clock, obtain Povidone Iodine Disinfection Solution.
Embodiment 8
The invention provides a kind of preparation method of Povidone Iodine Disinfection Solution, comprise the following steps：
S1,2.42 parts of deionized water stirring and dissolvings are added in 2.22 parts of polyvinylpyrrolidones, stirred 4.5 minutes, be made poly-
Vinylpyrrolidone solution for standby；
S2, under normal temperature, condition of normal pressure, 0.63 part of iodine is added in S1 in obtained polyvinylpyrrolidonesolution solution, stirring 2.8
Hour, 3.88 parts of NPEs are added, stir 10.7 hours, add 88.89 parts of deionized waters, stirring 23
Minute, obtain Povidone Iodine Disinfection Solution.
Embodiment 9
The invention provides a kind of preparation method of Povidone Iodine Disinfection Solution, comprise the following steps：
S1,1.87 parts of deionized water stirring and dissolvings are added in 1.7 parts of polyvinylpyrrolidones, stirred 6 minutes, polyethylene is made
Pyrrolidone solution is standby；
S2, under normal temperature, condition of normal pressure, 0.72 part of iodine is added in S1 in obtained polyvinylpyrrolidonesolution solution, stirring 2.1
Hour, 3.36 NPEs are added, stir 9.2 hours, add 97.25 deionized waters, are stirred 44 minutes,
Obtain Povidone Iodine Disinfection Solution.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (7)
1. a kind of Povidone Iodine Disinfection Solution, it is characterised in that its raw material includes by weight：Iodine 0.45-0.8 parts, polyethylene pyrrole
Pyrrolidone 1.5-2.5 parts, NPE 3-5 parts, deionized water 80-100 parts.
2. a kind of Povidone Iodine Disinfection Solution according to claim 1, it is characterised in that its raw material includes by weight：Iodine
0.5-0.7 parts, polyvinylpyrrolidone 1.8-2.3 parts, NPE 3.8-4.1 parts, deionized water 90-95 parts.
3. a kind of Povidone Iodine Disinfection Solution according to claim 1, it is characterised in that its raw material includes by weight：Iodine
0.58 part, 2.1 parts of polyvinylpyrrolidone, 3.94 parts of NPE, 93.43 parts of deionized water.
4. a kind of Povidone Iodine Disinfection Solution according to claim 1, it is characterised in that the polyvinylpyrrolidone is
PVP-K30。
5. a kind of Povidone Iodine Disinfection Solution according to claim 1, it is characterised in that the NPE is
TX-10。
6. a kind of preparation method of Povidone Iodine Disinfection Solution, it is characterised in that comprise the following steps：
S1, deionized water stirring and dissolving is added in polyvinylpyrrolidone, stir 4-6 minutes, polyvinylpyrrolidone is made
Solution for standby；
S2, under normal temperature, condition of normal pressure, iodine is added in S1 in obtained polyvinylpyrrolidonesolution solution, stirs 2-3 hours,
NPE is added, stirs 9-11 hour, adds deionized water, 20-45 minutes is stirred, obtains PVP-I
Thimerosal.
A kind of 7. preparation method of Povidone Iodine Disinfection Solution according to claim 6, it is characterised in that polyethylene in the S1
The weight of pyrrolidones and deionized water ratio is 1:1.1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710918393.8A CN107496448A (en) | 2017-09-30 | 2017-09-30 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710918393.8A CN107496448A (en) | 2017-09-30 | 2017-09-30 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107496448A true CN107496448A (en) | 2017-12-22 |
Family
ID=60700319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710918393.8A Pending CN107496448A (en) | 2017-09-30 | 2017-09-30 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107496448A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113801251A (en) * | 2021-10-14 | 2021-12-17 | 张正凯 | Preparation method of high-concentration compound povidone iodine |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593453A (en) * | 2003-09-10 | 2005-03-16 | 北京亚科希药物研究所 | Sterilizing and bacteria inhibiting pharmaceutical composition and its formulation and preparation process |
| CN1596908A (en) * | 2003-09-16 | 2005-03-23 | 北京亚科希药物研究所 | Sterilization bacteria inhibition compound iodophor medicine and its preparation and preparation technology |
| CN101176700A (en) * | 2007-10-29 | 2008-05-14 | 广东庆发药业有限公司 | Antimicrobial disinfection hand cleanser and preparation method thereof |
| CN102085159A (en) * | 2011-01-24 | 2011-06-08 | 长沙优威生物科技有限公司 | Nursing type disinfecting liquid soap |
| CN104434995A (en) * | 2014-11-28 | 2015-03-25 | 成都顺发消洗科技有限公司 | Preparation method of mucocutaneous disinfectant |
| CN105311050A (en) * | 2015-11-25 | 2016-02-10 | 上海银京医用卫生材料有限公司 | Traceless povidone iodine disinfectant |
| CN105311049A (en) * | 2014-06-15 | 2016-02-10 | 江苏三仪胜意药业有限公司 | Preparation method of veterinary-use povidone-iodine disinfectant liquid |
| CN106265728A (en) * | 2016-08-30 | 2017-01-04 | 赵阳 | A kind of method to the sterilization of Cuora flavomarginate whole body |
-
2017
- 2017-09-30 CN CN201710918393.8A patent/CN107496448A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593453A (en) * | 2003-09-10 | 2005-03-16 | 北京亚科希药物研究所 | Sterilizing and bacteria inhibiting pharmaceutical composition and its formulation and preparation process |
| CN1596908A (en) * | 2003-09-16 | 2005-03-23 | 北京亚科希药物研究所 | Sterilization bacteria inhibition compound iodophor medicine and its preparation and preparation technology |
| CN101176700A (en) * | 2007-10-29 | 2008-05-14 | 广东庆发药业有限公司 | Antimicrobial disinfection hand cleanser and preparation method thereof |
| CN102085159A (en) * | 2011-01-24 | 2011-06-08 | 长沙优威生物科技有限公司 | Nursing type disinfecting liquid soap |
| CN105311049A (en) * | 2014-06-15 | 2016-02-10 | 江苏三仪胜意药业有限公司 | Preparation method of veterinary-use povidone-iodine disinfectant liquid |
| CN104434995A (en) * | 2014-11-28 | 2015-03-25 | 成都顺发消洗科技有限公司 | Preparation method of mucocutaneous disinfectant |
| CN105311050A (en) * | 2015-11-25 | 2016-02-10 | 上海银京医用卫生材料有限公司 | Traceless povidone iodine disinfectant |
| CN106265728A (en) * | 2016-08-30 | 2017-01-04 | 赵阳 | A kind of method to the sterilization of Cuora flavomarginate whole body |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113801251A (en) * | 2021-10-14 | 2021-12-17 | 张正凯 | Preparation method of high-concentration compound povidone iodine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10265341B2 (en) | Hydrogel formulation comprising oxidative reductive potential water | |
| TWI407906B (en) | Disinfectant | |
| CN109316536A (en) | A kind of skin mucosa disinfecting agent and preparation method thereof | |
| CN104013573B (en) | Available iodine content is the liquid PVP-I of 5-12% | |
| CN102091097B (en) | Washing-free puerpera perineum medical-care gel and preparation method thereof | |
| TW201216859A (en) | Disinfectant and antiseptic formulation having reduced iodine content | |
| CN109771315A (en) | A kind of disposable hand-wrist bones gel of environment-friendly type and preparation method thereof | |
| CN113144281B (en) | Wound surface disinfection gel and preparation method thereof | |
| CN102614113A (en) | Compound washing-free disinfection gel | |
| CN101810639A (en) | Broad-spectrum touch-out medical bactericide and preparation method thereof | |
| CN101716186B (en) | Wound antibiotic flushing fluid and preparation method thereof | |
| CN107496448A (en) | A kind of Povidone Iodine Disinfection Solution and preparation method thereof | |
| CN106727669A (en) | A kind of efficiently gentle skin degerming gel and preparation method thereof | |
| CN107744524B (en) | Iodine-containing tincture antibacterial gel and preparation method thereof | |
| CN101816678A (en) | Broad-spectrum contact type hemostatic medical fungicide and preparation method thereof | |
| CN115152756B (en) | Inclusion compound disinfectant tablet and preparation method thereof | |
| CN106561707A (en) | Povidone iodine effervescent tablet with sterilization and disinfection effects, and preparation method thereof | |
| CN108938614A (en) | A kind of compound and its preparation method and application for treating open injury | |
| JPS63109865A (en) | Pullulan film preparation containing drug as effective component | |
| CN103181931A (en) | Povidone iodine five-compound disinfectant | |
| CN107582737A (en) | A kind of compound chlorohexidene oral-cavity disinfectant and preparation method thereof | |
| CN113648326B (en) | Nanoparticle-containing virus-inactivated disinfectant and preparation method thereof | |
| CN101091487B (en) | Antisepsis spraying agent in use for die plate of alginate, and preparation method | |
| CN108721328A (en) | Chitosan iodine biomaterial and preparation method thereof | |
| CN103202853A (en) | Povidone iodine four-component compound disinfectant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171222 |
|
| WD01 | Invention patent application deemed withdrawn after publication |