CN107485443A - One kind freezing compound ablation system of microwave - Google Patents
One kind freezing compound ablation system of microwave Download PDFInfo
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- CN107485443A CN107485443A CN201710859508.0A CN201710859508A CN107485443A CN 107485443 A CN107485443 A CN 107485443A CN 201710859508 A CN201710859508 A CN 201710859508A CN 107485443 A CN107485443 A CN 107485443A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/0091—Handpieces of the surgical instrument or device
- A61B2018/00916—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
- A61B2018/00958—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device for switching between different working modes of the main function
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
- A61B2018/0268—Characteristics of handpieces or probes using a circulating cryogenic fluid with restriction of flow
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Abstract
The invention discloses one kind to freeze the compound ablation system of microwave, belongs to technical field of medical equipment.The system includes display device, main frame, input equipment, control panel, microwave power source, freezing control gas circuit, power supply, ablation needle, argon gas source and helium gas source；Display device and input equipment electrically connect with main frame respectively；Main frame electrically connects with control panel；Control panel electrically connects with microwave power source and ablation needle respectively；Microwave power source is electrically connected by cable with ablation needle；Argon gas source and helium gas source control the air inlet of gas circuit to be connected by air delivering pipeline with freezing respectively；The gas outlet of freezing control gas circuit is connected by the air inlet of air delivering pipeline and ablation needle；Power supply electrically connects with main frame, control panel and microwave power source respectively.The freezing compound ablation system of microwave provided by the invention, can make doctor be directed to the situation of different patients, select cryoablation, microwave ablation or the freezing compound ablation mode of microwave.
Description
Technical field
The present invention relates to technical field of medical equipment, more particularly to a kind of freezing compound ablation system of microwave.
Background technology
The case that tumour is suffered from China and the world in recent years drastically rises.By taking liver cancer as an example, counted according to the World Health Organization,
The cut-off whole world in 2014 there are about 400,000,000 chronic hepatitis Bs and hepatitis C infections person, there are about 1,400,000 people every year and dies from hepatites virus infections, liver
There is 80% to be caused by hepatitis B and hepatitis in cancer death.
At present, the method for the treatment of cancer has many kinds, mainly including surgery excision, PCI, drug therapy, part
Ablation etc..Last decade has obtained quick development with the appearance of various ablation Medical Devices, local ablation therapy,
Mainly there are RF ablation (RFA), microwave ablation (MWA) and cryoablation (Cryoablation, cryoprobe) three in clinical practice
Kind.Local ablation therapy method has the characteristics that wound is small, treatment is accurate, it is fast to recover, operation risk is low and low-cost.Office
Portion's ablation according to its treat principle be divided into cold ablation and heating ablation (RF ablation and microwave ablation belong to heating ablation category,
But because the firing rate of microwave is fast, ablation range is big, operation facility relatively gradually has the trend for banning RF ablation).Compare
In heating ablation, cryoablation has the following advantages that：
1) operation principle of heating ablation operation is by cancerous issue calcination, makes protein coagulating or even be carbonized to reach inactivation
Purpose, its temperature may feel that very pain, poor resistance up to 100 DEG C of even more highs, patient；And performed the operation in cryoablation
During, because freezing has the function that analgesic in itself, therefore patient does not have the sensation of severe pain.
2) the inactivation scope of heating ablation only has 2cm or so, and solid tumor of such diameter more than 2cm can not be by whole
Inactivation, causes high recurrence rate, and by its principle is limited, it is more difficult to realize that spininess is used in combination.And cryoablation can inactivate
More than diameter 2cm solid tumor, and can be used in combination with spininess, make inactivation scope bigger, heating ablation can be reached and gone out
5~6 times of scope living.
3) if knub position is close to blood vessel, heating ablation is not available for treating；Reason is that heating ablation can burn blood vessel
Burning hole, cause massive haemorrhage.And cryoablation can carry out ablation to the tumour beside blood vessel, because blood vessel is by connective
Organizational composition is resistant to low temperature, therefore can carry out cryoablation.If knub position is close to the swollen of abdominal cavity edge or diaphram
Knurl, heating ablation is not available for treating, and cryoablation can treat.As can be seen here, the indication scope of cryoablation is wider.
4) cryoablation has immunology effect：Freezing disturbs the biological activity of oncocytology and remained swollen
The structure of tumor antigen albumen, the immune response of specificity antineoplastic can be improved, while ablation tissue liquefaction is easy to absorb
Fall.And to be indifference ablation can make tissue protein solidification even " carbonization " improve the immune anti-of specificity antineoplastic for heating ablation
Should not significantly, while carbide texture caused by heating ablation is difficult to absorb, patient has foreign body sensation and non-infectious inflammation for a long time
In the presence of.
Although cryoablation has many advantages, such as above-mentioned, cryoablation has certain ablation needle gastrointestinal hemorrhage risk, cold
Only can be by temperature rewarming to 40 DEG C during jelly rewarming, it is impossible to which making blood coagulating protein coagulation, (protein coagulating temperature is generally 57
℃).And heating ablation, when being performed the operation, temperature can reach more than 90 DEG C, can solidify blood coagulating protein, play a part of hemostasis.
Therefore, how to make full use of the advantages of cryoablation and heating ablation, so as to it is safer, treat tumour to a greater extent, be medical treatment
The problem of technical staff pays special attention to.
The content of the invention
In order to solve the limitation that cryoablation and microwave ablation are individually present, the invention provides one kind to freeze microwave
Compound ablation system, including display device, main frame, input equipment, control panel, microwave power source, freezing control gas circuit, power supply,
Ablation needle, argon gas source and helium gas source；The display device and the input equipment electrically connect with the main frame respectively；The master
Machine electrically connects with the control panel；The control panel electrically connects with the microwave power source and the ablation needle respectively；It is described micro-
Wave power source is electrically connected by cable with the ablation needle；The argon gas source and helium gas source respectively by air delivering pipeline with it is described
The air inlet connection of freezing control gas circuit；The gas outlet of the freezing control gas circuit passes through air delivering pipeline and the ablation needle
Air inlet connects；The power supply electrically connects with the main frame, the control panel and the microwave power source respectively.
The freezing control gas circuit includes relay, first filter, the first safety valve, the first magnetic valve, the second filtering
Device, the second safety valve, second solenoid valve, the 3rd magnetic valve and gas distribution branch road；The output end of the control panel with it is described after
The input electrical connection of electrical equipment, the output end of the relay respectively with first magnetic valve, the second solenoid valve, institute
State the 3rd magnetic valve and gas distribution branch road electrical connection；The entrance of the first filter by air delivering pipeline with it is described
Argon gas source is connected, and the outlet of the first filter is connected with the arrival end of first safety valve；First safety valve
The port of export is connected with the arrival end of first magnetic valve；The port of export of first magnetic valve and gas distribution branch road
Arrival end connection；The entrance of second filter is connected by air delivering pipeline with the helium gas source, second filter
Outlet be connected with the arrival end of second safety valve；The port of export of second safety valve and the second solenoid valve
Arrival end is connected, and the port of export of the second solenoid valve is connected with the arrival end of gas distribution branch road；The gas distribution
The port of export of branch road is connected with the air inlet of the ablation needle；The arrival end of 3rd magnetic valve and first safety valve
The port of export connection；The port of export connection exhaust outlet of 3rd magnetic valve.
The multiple gas distribution members parallel with one another of the gas distribution branch route are formed；The gas distribution member bag
Include first gas distribution magnetic valve, second gas distribution magnetic valve, cooling gas check valve and gas distribution filter；Described first
The arrival end of gas distribution magnetic valve connects with the arrival end of the cooling gas check valve and the port of export of first magnetic valve respectively
Connect；The arrival end of the second gas distribution magnetic valve port of export with the cooling gas check valve and second electromagnetism respectively
The port of export connection of valve；The outlet of the first gas distribution magnetic valve and second gas distribution magnetic valve and the gas
The arrival end connection of body distribution filter；The port of export of the gas distribution filter is connected with the air inlet of the ablation needle.
The ablation needle includes pin body, snorkel, radiation head, felt pad, transmission cable, thermal insulation layer, shell, handle
And thermocouple；The tip of the snorkel is provided with throttle orifice；The pin body and the cage connection；The shell it is interior
Wall is provided with the thermal insulation layer；The tail end of the shell is connected with the handle；The snorkel is parallel with the transmission cable
It is arranged in the shell, and extends in the handle；The radiation head is arranged at the tip of the pin body, and
It is connected with the transmission cable；The junction of the transmission cable and the radiation head is provided with the felt pad；The thermoelectricity
Occasionally it is arranged in the shell.
The control panel include central controller, A/D converter, the first temperature acquisition interface, multi-channel PWM output module,
Communication module and PID modulators；The first temperature acquisition interface electrically connects with the thermocouple；First temperature acquisition
Interface electrically connects with the A/D converter；The A/D converter electrically connects with the central controller；The PID modulators
Electrically connected respectively with the central controller and the microwave power source；The communication module respectively with the central controller
Electrically connected with the main frame；The multi-channel PWM output module electrically connects with the central controller and the relay respectively.
Further, the system also includes thermoprobe, and the thermoprobe electrically connects with the control panel.
Further, the control panel also includes second temperature acquisition interface；The second temperature acquisition interface respectively with
The thermoprobe and A/D converter electrical connection.
The microwave power source includes the first microwave power source and the second microwave power source；First microwave power source
Frequency be 915MHz, the frequency of second microwave power source is 2450MHz.
The input equipment includes keyboard or mouse.
The display device includes LCDs or touch liquid crystal display.
The freezing compound ablation system of microwave provided by the invention, doctor can be made to be directed to the situation of different patients, selection freezing
Ablation, microwave ablation or the freezing compound ablation of microwave, realize the Integration Design of cryoablation and microwave ablation, reduce
The purchase cost of ablation apparatus, it is easy to use, automaticity is high, expenses of surgical treatment is significantly reduced, is greatly promoted
The fast development of Minimally Invasive Surgery.The freezing compound ablation system of microwave provided by the invention, essence can be carried out to the temperature of ablation needle
It accurate control, so can not only prevent from injuring normal structure, but also tumour cell can be avoided seriously to be carbonized.
Brief description of the drawings
Fig. 1 is the structural representation of the freezing compound ablation system of microwave of the embodiment of the present invention；
Fig. 2 is the structural representation of ablation needle of the embodiment of the present invention；
Fig. 3 is the application implementation of the freezing compound ablation system of microwave of the embodiment of the present invention；
Fig. 4 is the structural representation of control panel of the embodiment of the present invention；
Fig. 5 is the composition schematic diagram of PID modulators of the embodiment of the present invention.
Embodiment
With reference to the accompanying drawings and examples, technical solution of the present invention is further described.
Cryoablation technology has been widely used in the diseases such as clinical treatment tumour.Cryoablation technology belongs to pure physics
Treatment, makes target area reach -150 DEG C, then is rapidly heated to 40 DEG C, wipes out tumour cell, therapeutic effect is definitely, no
Cancer cell diffusion, the minimally invasive no pain of process can be caused, recover fast, do not damage normal structure, have no toxic side effect, improved antitumor
Immune factor.Existing cryoprobe utilizes Joule-Thomson principle, and the position to be treated of cryoprobe insertion is treated,
High pressure argon gas reaches the purpose of fast-refrigerating by the throttle orifice throttling of probe interior front end, then reaches fast by high-pressure helium
The purpose of speed heating.
Microwave ablation techniques be it is a kind of have to tumor tissues efficiently, it is quick, uniformly heating, thermocoagulation thoroughly, user
Just, safe treatment method, is widely used to clinic for many years.It is by the microwave needle of a Gent, percutaneous puncture to tumour
Central area, " miniature micro-wave oven " containing 1 mm in size on the certain point of microwave needle, the microwave magnetic discharged by it
Field can make the molecule high speed rotary motion of surrounding and friction generates heat；When temperature is increased to more than 60 DEG C, tumour cell
Protein denaturation solidification, change the environment residing for tumour cell, cause its irreversibility downright bad, so that tissue coagulation, de-
Water necrosis, reach the purpose for the treatment of.Simultaneously as heat caused by microwave ablation can make protein coagulating, have well only
Blood acts on.
Referring to Fig. 1, the advantages of embodiment of the present invention utilizes cryoablation and microwave ablation, there is provided one kind can be carried out
The system that cryoablation can carry out microwave ablation again, in order to make doctor be directed to different patients situation, select cryoablation,
Microwave ablation or the freezing compound ablation of microwave.The freezing compound ablation system of microwave provided in an embodiment of the present invention is set including display
Standby 1, input equipment 2, main frame 3, control panel 4, microwave power source 5, freezing control gas circuit 6, power supply 7, ablation needle 8, argon gas source 9
With helium gas source 10.Wherein, display device 1 and input equipment 2 electrically connect with main frame 3 respectively；Main frame 3 electrically connects with control panel 4；
Control panel 4 electrically connects with microwave power source 5 and ablation needle 8 respectively；Microwave power source 5 is electrically connected by cable with ablation needle 8；
Argon gas source 9 and helium gas source 10 control the air inlet of gas circuit 6 to be connected by air delivering pipeline with freezing respectively；Freezing control gas circuit 6
Gas outlet is connected by air delivering pipeline with the air inlet of ablation needle 8；Power supply 7 respectively with main frame 3, control panel 4 and microwave power source
5 electrical connections.
Referring to Fig. 1, freezing control gas circuit 6 of the embodiment of the present invention include relay 601, filter 602, safety valve 603,
Magnetic valve 604, filter 605, safety valve 606, magnetic valve 607, magnetic valve 608 and gas distribution branch road；Control panel 4 it is defeated
Go out end to electrically connect with the input of relay 601, the output end of relay 601 respectively with magnetic valve 604, magnetic valve 607, electric
Magnet valve 608 and gas distribution branch road electrical connection；The entrance of filter 602 is connected by air delivering pipeline with argon gas source 9, filter
602 outlet is connected with the arrival end of safety valve 603；The port of export of safety valve 603 is connected with the arrival end of magnetic valve 604；Electricity
The port of export of magnet valve 604 is connected with the arrival end of gas distribution branch road；The entrance of filter 605 passes through air delivering pipeline and helium
Source 10 is connected, and the outlet of filter 605 is connected with the arrival end of safety valve 606；The port of export of safety valve 606 and magnetic valve 607
Arrival end connection, the arrival end that the port of export of magnetic valve 607 distributes branch road with gas is connected；Gas distributes the outlet of branch road
End is connected with the air inlet of ablation needle 8；The arrival end of magnetic valve 608 is connected with the port of export of safety valve 603；Magnetic valve 608
The port of export connects exhaust outlet.Further, the gas distribution branch of the present embodiment route multiple gas distribution members parallel with one another
Form, each gas distribution member includes gas distribution magnetic valve 609, gas distribution magnetic valve 610, the and of cooling gas check valve 611
Gas distributes filter 612；The arrival end arrival end and electricity with cooling gas check valve 611 respectively of gas distribution magnetic valve 609
The port of export connection of magnet valve 604；The arrival end port of export and electricity with cooling gas check valve 611 respectively of gas distribution magnetic valve 610
The port of export connection of magnet valve 607；Gas distributes magnetic valve 609 and the outlet of gas distribution magnetic valve 610 is filtered with gas distribution
The arrival end connection of device 612；The port of export of gas distribution filter 612 is connected with the air inlet of ablation needle 8.In practical application
In, filter 602, filter 605 and gas distribution filter 612 are used to filter the impurity and steam in gas.Need
Bright is：In order to realize the accurate control to ablation needle temperature, the injury of normal tissue is avoided, gas distribution branch road should be adopted
With multichannel gas distribution channels such as 8 tunnels, 10 tunnels or 12 tunnels；For example, the present embodiment uses 8 road gas distribution channels, by control panel 4 to 8
The magnetic valve of road gas distribution channel carries out alternately control, realizes the regulation of freezing power, and then the accurate temperature for controlling ablation needle 8.
Referring to Fig. 2, the ablation needle 8 of the embodiment of the present invention has a function of freezing and microwave radiation, including pin body 81,
Snorkel 82, radiation head 83, felt pad 84, transmission cable 85, thermal insulation layer 86, shell 87, handle 88 and thermocouple 89.Wherein,
The tip of snorkel 82 is provided with throttle orifice；Pin body 81 is connected with shell 87；The inwall of shell 87 is provided with thermal insulation layer 86；
The tail end of shell 87 is connected with handle 88；Snorkel 82 is set in parallel in shell 87 with transmission cable 85, and extends to handle
In 88；Radiation head 83 is arranged at the tip of pin body 81, and is connected with transmission cable 85；Transmission cable 85 and radiation head
83 junction is provided with felt pad 84；Thermocouple 89 is arranged in shell 87.Ablation needle 8 can both apply Joule-Thomson
Principle carry out cryoablation, also heating ablation can be carried out by microwave.When being freezed, high pressure argon gas is melting ablation needle 8
Throttle effect occurs for the point of pin, produces cold, and reflux gas flows back out of ablation needle；When carrying out microwave heating, power
Source is transferred to radiation head 83, and the part between being arrived at the tip of pin body 81 to felt pad 84 causes tissue element to external radiation
Warm-up movement produces heat.Thermocouple 89 is used to gather the temperature inside ablation needle 8 in real time.Thermal insulation layer 86 can prevent shell 87
Frostbite or normal structure of burning.
Referring to Fig. 4, control panel of the embodiment of the present invention 4 includes central controller MCU41, A/D converter 42, temperature acquisition
Interface 43, multi-channel PWM output module 44, communication module 45 and PID modulators 46.Wherein, temperature acquisition interface 43 and thermocouple
89 electrical connections；Temperature acquisition interface 43 electrically connects with A/D converter 42；A/D converter 42 electrically connects with central controller 41；
PID modulators 46 electrically connect with central controller 41 and microwave power source 5 respectively；Communication module 45 respectively with central controller
41 and main frame 3 electrically connect；Multi-channel PWM output module 44 electrically connects with central controller 41 and relay 601 respectively.
In actual applications, microwave power source 5 includes microwave power source 51 and microwave power source 52, as shown in Fig. 1；It is micro-
The frequency in wave power source 51 is 915MHz, and the frequency of microwave power source 52 is 2450MHz；Doctor can according to different focuses,
Select the microwave power source of different frequency.Display device 1 may include LCDs or touch liquid crystal display etc., be used for
Show freezing state, freezing power, time, ablation needle temperature, real-time working air pressure, microwave frequency selection, microwave power, mistake
The system informations such as false alarm.Input equipment 3 may include keyboard or mouse etc., the service aisle different for doctor's operation unlatching,
Regulation freezing power, selection rewarming mode, selection microwave frequency, selection microwave power etc..
In addition, the freezing compound ablation system of microwave provided in an embodiment of the present invention can also further comprise thermoprobe 11,
Thermoprobe 11 electrically connects with control panel 4, for measuring the temperature of cryoablation or microwave ablation scope, and then monitors freezing
Or heating ablation regional temperature, avoid the injury of normal tissue and determine ablation range.Correspondingly, control panel 4 further comprises
Temperature acquisition interface 47, temperature acquisition interface 47 electrically connect with thermoprobe 11 and A/D converter 42 respectively.
In actual applications, thermoprobe 11 can use T-shaped thermocouple.It should be noted that：In order to more accurately sentence
The temperature of disconnected cryoablation or microwave ablation scope, to avoid the injury of normal tissue, can use 8 tunnels, 10 tunnels or 12 tunnels
Deng the mode of multichannel temperature measurement；For example, the present embodiment selects 8 tunnel temperature survey modes, i.e., formed using 8 T-shaped thermocouples
Thermoprobe, 8 T-shaped thermocouples are separately positioned on cryoablation or the diverse location of microwave ablation scope, to realize multiple spot
Temperature monitoring.
Referring to Fig. 3, the freezing compound ablation system of microwave provided in an embodiment of the present invention has multiple-working mode.Curing
It is raw to implement before operation, it is necessary to according to the concrete condition of ablation focus, select cryoablation, microwave ablation or the two be combined
Compound ablation mode.The operation principle of above-mentioned three kinds of mode of operations is simply summarized below：
1) cryoablation pattern：Low temperature can be produced after being throttled using high pressure argon gas, and liter can be produced after high-pressure helium throttling
The physical characteristic of temperature；Gas (argon gas and helium) enters ablation needle 8 after flowing through freezing control gas circuit 6, at the tip of ablation needle 8
Position produces throttle effect.For the embodiment of the present invention when controlling cryoablation, control panel 4 receives input equipment 2 by main frame 3
The operational order issued, control relay 601 are turned on and off, and then relay 601 controls magnetic valve 604 or magnetic valve 607
Break-make, realize the control to gas break-make.The cryoablation pattern of the embodiment of the present invention has the work(of adjustment freezing power
Can, specific implementation is that the make-and-break time of magnetic valve is adjusted within an electromagnetic valve work cycle, such as：It is one to set 5 seconds
The work period of individual magnetic valve, set by 0%~100%, stepped intervals 5%, totally 20 different power grades；If
The freezing power of selection 5%, as 1/20 electromagnetic valve work cycle, as 0.25 second, then in the magnetic valve work of 5 seconds
Make in the cycle, relay 601 will be opened 0.25 second, closed 4.75 seconds, and control magnetic valve is ventilated 0.25 second, closed 4.75 seconds.
2) microwave ablation pattern：The embodiment of the present invention integrates two independent microwave power sources, the i.e. He of microwave power source 51
Microwave power source 52, output frequency are 915MHz and 2450MHz respectively, and two power sources are 0~300 watt of dynamic adjustable type.
Microwave power source exports the microwave of 915MHz or 2450MHz frequencies, by cable transmission to ablation needle 8, the spoke in ablation needle 8
Penetrate head can overturn molecule near its tip location friction generates heat.Melted with different frequency, therapeutic effect is not
Together；915MHz can reach bigger ablated volume, and 2450MHz heating rates are faster.Doctor can not sympathizing with according to patient
Condition, select 2450MHz " quick mode ", or 915MHz " general modfel ".The embodiment of the present invention is that doctor sets " certainly
It is dynamic " and " manual " two kinds of working methods；When selecting " automatic " working method, doctor can according to puncture position, size of tumor,
Surrounding tissue etc. is set to the process of ablation, that is, sets the parameters such as microwave time, power, temperature, system is according to setting
The course of work carries out microwave ablation；When selecting " manual " working method, doctor can be disappeared by the focus that CT or color ultrasound reflect
The temperature of ablation needle in the degree and display melted, the power of microwave power source is adjusted in real time.During microwave ablation,
Adaptive dynamic power regulation is carried out by PID modulators, realizes and accurate temperature control is carried out to ablation needle, to prevent temperature
The adhesion of carbonized and ablation tissue and ablation needle caused by spending height, ablation caused by overcoming temperature too low be not thorough；Doctor
Take root according to different focuses, using different accurate temperature controls, as shown in Figure 4：A/D converter disappears what thermocouple gathered
Melt the temperature value inside pin and be converted into data signal, and exported after central controller MCU processing and give PID modulators；PID
Modulated signal is sent to microwave power source by modulator；Microwave power source adjusts power output according to the modulated signal received.
PID modulators are made up of proportional unit P, integral unit I and differentiation element D, as shown in Figure 5；Proportional unit P adjusts temperature control
The degree of error of system, Kp numerical value is bigger, and error is smaller, but system response time can be caused to lengthen, so needing integral unit I to increase
Add response speed, while processing, three parameter K are filtered using differentiation element Dp、KiAnd KdComplement each other, so as to reach
Optimal temperature is precisely controlled.
In actual applications, due to ablation needle, individual has differences in itself, and ablation locations are different, therefore can cause
Ablation needle load is different, and this just needs the parameter for adjusting PID modulators.By many experiments early stage, research finds microwave
During ablation heating, the heating rate of ablation needle can reflect its performance difference and load difference.Accordingly, the embodiment of the present invention is led to
The heating rate of 30 seconds before collection microwave ablation is crossed, calculates three optimal parameters of PID modulators.Choose different heating speed
The ablation needle of rate is tested, and collects experimental data, carries out the data fitting of three parameters.Set the heating speed of initial 30 seconds
Rate is V, i.e. V is equal to temperature inversion value Δ TemDivided by time t (t is equal to 30 seconds), three pre-set parameters of PID modulators are
Kp、KiAnd Kd, using secondary power, the method for three supplemental characteristics fitting, empirical curve is returned, and then obtain three ginsengs
Several coefficient, if its coefficient is (AP1, AP2, AP3), (Ai1, Ai2, Ai3), (Ad1, Ad2, Ad3), then
It is fitted by 2 power data, has obtained the coefficient of correspondence of three parameters of PID modulators.Heated up carrying out microwave
Cheng Zhong, according to the rate of temperature fall V of 30 seconds before the ablation needle, obtain three parameter value K for corresponding to optimal PID modulatorsp、KiWith
Kd。
Because ablation needle has individual configurations difference, therefore its programming rate is different.In operation, can only pass through
The subjective judgement of doctor, microwave power source power is adjusted manually.And performed the operation for microwave ablation, the temperature of ablation needle has very
Big meaning.Due to microwave programming rate quickly, up to a hundred degrees Celsius of high temperature can be reached in tens seconds, if temperature mistake
Height, tumour perienchyma scald being not only resulted in, tumour cell is also resulted in and is seriously carbonized, patient has serious pain,
And the tissue being seriously carbonized, body are difficult to absorb, and patient has foreign body sensation, it is possible to create the adverse reaction such as repulsion.This implementation
Example central controller calculates optimal pid parameter, and the parameter is exported according to the temperature value inside the ablation needle of collection
To PID regulator, and then the power output of dynamic regulation microwave power source, realize and microwave ablation temperature be precisely controlled,
It so can not only prevent from injuring normal structure, but also tumour cell can be avoided seriously to be carbonized.
3) the compound ablation mode of microwave is freezed：The embodiment of the present invention is by freeze the means as cell inactivation, during rewarming
Applied microwave, focus is subjected to secondary inactivation, while can also be that needle track stops blooding.This mode of operation can effectively improve ablation
Overall inactivation ratio, reduce residual activity and tissue transfer risk.
When melting beginning, doctor operates three kinds of different mode of operations of input equipment selection, and (cryoablation, microwave disappear
Melt or freeze the compound ablation of microwave).In cryoablation, gas is passed through ablation needle through magnetic valve by gas cylinder and realizes refrigeration；Control
The instruction that plate is issued by main frame reception input equipment, control relay, and then magnetic valve break-make is controlled, realize to gas
It is passed through control；Meanwhile by adjusting the opening and closing time of magnetic valve, adjust refrigeration work consumption；The inside of ablation needle has heat
Galvanic couple, control panel carries out temperature acquisition to it, and is transferred to main frame, and then the real time temperature of ablation needle is included setting in display
It is standby upper.In microwave ablation, doctor can choose " quick mode " or " general modfel " according to different focus situations；" Fast Modular
Formula " uses microwave power source of the output frequency for 2450MHz, and " general modfel " uses microwave work(of the output frequency for 915MHz
Rate source；Two kinds of mode of operations all have " automatic " and " manual " working method.In the compound ablation of freezing microwave, the present embodiment
Ablation needle can not only be worked with freezing mode, but also can be worked with microwave mode；During freezing, the present embodiment system passes through
Gas throttling realizes refrigeration；During rewarming, the present embodiment can increase rewarming time using microwave power source output microwave signal；
While stopping blooding for needle track, can also secondary ablation be carried out to needle path, prevent needle track implantation from shifting.
The freezing compound ablation system of microwave provided in an embodiment of the present invention, can make doctor be directed to the situation of different patients, choosing
Select cryoablation, microwave ablation or the freezing compound ablation of microwave.Such as patient tumors are located proximate to big blood vessel, such as with microwave, penetrate
The heating ablation modes such as frequency, can injuring tumor periphery blood vessel, cause massive haemorrhage, and the system that doctor uses the embodiment of the present invention, can
Cryoablation mode is selected, on the premise of not injured blood vessel, tumour can be subjected to ablation inactivation；In another example treatment blood vessel
During knurl, because its blood supply is enriched, such as apply cryoablation, have a bleeding risk, and doctor is using the system of the embodiment of the present invention,
Microwave ablation mode can be selected, while treatment, the effect of hemostasis can be reached.In addition, doctor uses the embodiment of the present invention
System, the freezing compound ablation mode of microwave may be selected, melted using freezing, applied microwave carries out needle track hemostasis and pin
The secondary ablation in road, Implantation matastasis can also be prevented while hemostasis.The compound ablation system of freezing microwave provided in an embodiment of the present invention
System, realize the Integration Design of cryoablation and microwave ablation, reduce the purchase cost of ablation apparatus, it is easy to use, from
Dynamicization degree is high, significantly reduces expenses of surgical treatment, greatly advances the fast development of Minimally Invasive Surgery.
Particular embodiments described above, the purpose of the present invention, technical scheme and beneficial effect are carried out further in detail
Describe in detail it is bright, should be understood that the foregoing is only the present invention specific embodiment, be not intended to limit the invention, it is all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements done etc., it should be included in the guarantor of the present invention
Within the scope of shield.
Claims (10)
1. one kind freezing the compound ablation system of microwave, it is characterised in that including display device, main frame, input equipment, control panel,
Microwave power source, freezing control gas circuit, power supply, ablation needle, argon gas source and helium gas source；The display device and the input equipment
Electrically connected respectively with the main frame；The main frame electrically connects with the control panel；The control panel respectively with the microwave power
Source and ablation needle electrical connection；The microwave power source is electrically connected by cable with the ablation needle；The argon gas source and helium
Source of the gas controls the air inlet of gas circuit to be connected by air delivering pipeline with the freezing respectively；The gas outlet of the freezing control gas circuit leads to
The air inlet that air delivering pipeline is crossed with the ablation needle is connected；The power supply respectively with the main frame, the control panel and described micro-
Wave power source electrically connects.
2. as claimed in claim 1 freezing the compound ablation system of microwave, it is characterised in that it is described freezing control gas circuit include after
Electrical equipment, first filter, the first safety valve, the first magnetic valve, the second filter, the second safety valve, second solenoid valve, the 3rd electricity
Magnet valve and gas distribution branch road；The output end of the control panel electrically connects with the input of the relay, the relay
Output end is electric with first magnetic valve, the second solenoid valve, the 3rd magnetic valve and the gas distribution branch road respectively
Connection；The entrance of the first filter is connected by air delivering pipeline with the argon gas source, the outlet of the first filter with
The arrival end connection of first safety valve；The arrival end of the port of export of first safety valve and first magnetic valve connects
Connect；The port of export of first magnetic valve is connected with the arrival end of gas distribution branch road；The entrance of second filter
It is connected by air delivering pipeline with the helium gas source, the outlet of second filter connects with the arrival end of second safety valve
Connect；The port of export of second safety valve is connected with the arrival end of the second solenoid valve, the port of export of the second solenoid valve
It is connected with the arrival end of gas distribution branch road；The air inlet of the port of export and the ablation needle of the gas distribution branch road connects
Connect；The arrival end of 3rd magnetic valve is connected with the port of export of first safety valve；The port of export of 3rd magnetic valve
Connect exhaust outlet.
3. the freezing compound ablation system of microwave as claimed in claim 2, it is characterised in that the gas distribution branch route is multiple
Gas distribution member parallel with one another is formed；The gas distribution member includes first gas distribution magnetic valve, second gas point
Filter is distributed with magnetic valve, cooling gas check valve and gas；The arrival end of first gas distribution magnetic valve respectively with it is described
The arrival end of cooling gas check valve connects with the port of export of first magnetic valve；The arrival end of the second gas distribution magnetic valve
It is connected respectively with the port of export of the cooling gas check valve and the port of export of the second solenoid valve；The first gas distributes electromagnetism
The outlet of valve and second gas distribution magnetic valve is connected with the arrival end of gas distribution filter；The gas distribution
The port of export of filter is connected with the air inlet of the ablation needle.
4. as claimed in claim 3 freezing the compound ablation system of microwave, it is characterised in that the ablation needle include pin body,
Snorkel, radiation head, felt pad, transmission cable, thermal insulation layer, shell, handle and thermocouple；The tip of the snorkel is provided with
Throttle orifice；The pin body and the cage connection；The inwall of the shell is provided with the thermal insulation layer；The tail end of the shell
It is connected with the handle；The snorkel is set in parallel in the shell with the transmission cable, and extends to the handle
It is interior；The radiation head is arranged at the tip of the pin body, and is connected with the transmission cable；The transmission cable and institute
The junction for stating radiation head is provided with the felt pad；The thermocouple is arranged in the shell.
5. the freezing compound ablation system of microwave as claimed in claim 4, it is characterised in that the control panel includes center and controlled
Device, A/D converter, the first temperature acquisition interface, multi-channel PWM output module, communication module and PID modulators；First temperature
Degree acquisition interface electrically connects with the thermocouple；The first temperature acquisition interface electrically connects with the A/D converter；The A/
D converters electrically connect with the central controller；The PID modulators respectively with the central controller and the microwave power
Source electrically connects；The communication module electrically connects with the central controller and the main frame respectively；The multi-channel PWM output module
Electrically connected respectively with the central controller and the relay.
6. the freezing compound ablation system of microwave as claimed in claim 5, it is characterised in that the system also includes thermometric and visited
Pin, the thermoprobe electrically connect with the control panel.
7. the freezing compound ablation system of microwave as claimed in claim 6, it is characterised in that the control panel also includes the second temperature
Spend acquisition interface；The second temperature acquisition interface electrically connects with the thermoprobe and the A/D converter respectively.
8. the compound ablation system of freezing microwave as described in claim 5 or 7, it is characterised in that the microwave power source includes
First microwave power source and the second microwave power source；The frequency of first microwave power source is 915MHz, second microwave
The frequency of power source is 2450MHz.
9. the compound ablation system of freezing microwave as described in claim 5 or 7, it is characterised in that the input equipment includes key
Disk or mouse.
10. the compound ablation system of freezing microwave as described in claim 5 or 7, it is characterised in that the display device includes liquid
Crystal display screen or touch liquid crystal display.
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| CN113952021A (en) * | 2021-11-30 | 2022-01-21 | 北京阳光易帮医疗科技有限公司 | Refrigeration high-frequency energy system and control method thereof |
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Address after: Room 201, 2nd floor, 5th floor, 8th courtyard, Kechuang Sanjie, Daxing Economic and Technological Development Zone, Beijing 102600 Applicant after: BEIJING YANGGUANG YIBANG MEDICAL TECHNOLOGY CO.,LTD. Address before: Room 201, 2nd floor, No. 5 Building, No. 8 Courtyard, Kechuang Third Street, Tongzhou Economic and Technological Development Zone, 102600, Beijing Applicant before: BEIJING YANGGUANG YIBANG MEDICAL TECHNOLOGY CO.,LTD. |
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