CN107422138A - A kind of rail mounted system for pretreating sample - Google Patents
A kind of rail mounted system for pretreating sample Download PDFInfo
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- CN107422138A CN107422138A CN201710689623.8A CN201710689623A CN107422138A CN 107422138 A CN107422138 A CN 107422138A CN 201710689623 A CN201710689623 A CN 201710689623A CN 107422138 A CN107422138 A CN 107422138A
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 101
- 238000011049 filling Methods 0.000 claims abstract description 14
- 239000000523 sample Substances 0.000 claims description 222
- 239000007788 liquid Substances 0.000 claims description 50
- 230000007246 mechanism Effects 0.000 claims description 32
- 238000004140 cleaning Methods 0.000 claims description 28
- 238000005119 centrifugation Methods 0.000 claims description 21
- 239000012530 fluid Substances 0.000 claims description 13
- 239000006228 supernatant Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 108010006464 Hemolysin Proteins Proteins 0.000 claims description 9
- 239000003228 hemolysin Substances 0.000 claims description 9
- 238000011534 incubation Methods 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 3
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 12
- 238000002360 preparation method Methods 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 3
- 238000004458 analytical method Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 11
- 230000008569 process Effects 0.000 description 9
- 238000011160 research Methods 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000004895 subcellular structure Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00495—Centrifuges
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
- G01N2035/009—Displaying information to the operator alarms, e.g. audible
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1058—General features of the devices using the transfer device for another function for mixing
- G01N2035/106—General features of the devices using the transfer device for another function for mixing by sucking and blowing
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- Chemical & Material Sciences (AREA)
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- Analytical Chemistry (AREA)
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Robotics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to cytologic technology field, disclose a kind of rail mounted system for pretreating sample, the shortcomings that system can be good at overcoming artificial treatment to bring, the cell preparation work of blood sample before machine analysis on flow cytometer is completed, artificial and can be largely saved and improve blood sample treatment effect.Also, module is moved by sample introduction in the present invention and realizes movement on XYZ axle any directions, completes the filling of sample and antibody；Movement on XYZ axle any directions is realized by carriage movement module, reaction tube is transported in centrifugal pan and centrifuged, overcomes the limitation of azimuth motion in the prior art.
Description
Technical field
The invention belongs to cytologic technology field, discloses a kind of rail mounted system for pretreating sample.
Background technology
Flow cytometry (Flow Cytometry, FCM) is that one kind can quickly be surveyed to cell or subcellular structure
The new analytical technology and sorting technology of amount.It is characterized in：1. measuring speed is fast, can most be measured soon at 1 second in kind tens thousand of thin
Born of the same parents；2. measuring multiple parameters can be carried out, the measuring multiple parameters about Wuli-Shili-Renli system approach can be done to same cell, and have
Obvious statistical significance；3. being a comprehensive high-tech approach, it combines laser technology, computer technology, fluid
Mechanics, cytochemistry, image technique etc. are from multi-field knowledge and achievement；It is accurate point again 4. being both cell analysis technology
Selecting technology.It is that cell sample prepares quality to influence one of key factor of flow cytometry success or failure.Generally, such cell
Pretreatment is mainly manually performed using more times and labour as cost.Due to inevitable mistake and from one
Individual individual operator to another individual operator operator's nonuniformity the reason for, manually pretreatment and it is worthless.
Appearance therefore, it is possible to the full-automatic equipment for carrying out cell pretreatment is expected for a long time, to eliminate the mankind by cytologist
Stabilization that is painstaking and obtaining involved operation and constant.Because the complexity of cell pretreatment process, such system or equipment
It is not well-known.
The present invention seeks offer can be with full automation and modern times before flow cytometer and similar cell research
The system that change mode performs sample preparation automatically.The system is suitable to the preparation of whole blood sample and (pre-) processing.
The shortcomings that system for pretreating sample project can be good at overcoming artificial treatment to bring, perfection solve flow cytometer
The cell preparation work of blood sample before upper machine；Artificial and can largely be saved and improve blood sample treatment effect.
The content of the invention
Can before flow cytometer and similar cell research the technical problem to be solved in the present invention is to provide one kind
The system for performing sample preparation automatically with full automation and modern method, and any movement of XYZ axles can be realized, carry out
Fill sample, antibody and carry out reactant transport pipe.
In order to solve the above technical problems, the invention discloses a kind of rail mounted system for pretreating sample, including agent bin, bag
Include and be disposed on sample antibody moiety and reaction module, the sample antibody moiety includes sample box and antibody box, the sample
The sample tube seat for placing sample tube is arranged at intervals with this box；It is arranged at intervals with the antibody box for placing antibody pipe
Antibody tube seat；The antibody box is arranged on the side of the sample box；
The reaction module, between realizing that the incubation and mixing of sample and antibody, including reaction box, the reaction box are interior
Every being provided with the reaction tube seat for placing response pipe, the first drive mechanism, the reaction box are provided with below the reaction box
Rotated under the driving of the first drive mechanism；
Sample introduction moves module, including the first single shaft driver, is provided with and is used for described on the first single shaft driver
The sample introduction needle of sample and antibody is filled in reaction tube, the sample introduction motion module drives the sample introduction needle along XYZ axle any directions
Upper movement, the sample and antibody are filled into the reaction tube；
First liquid relief arm module, including the first probe and the first mechanical arm for fixing first probe, described
One mechanical arm drives the rotation of the first probe and movement, and first probe is used to fill hemolysin and PBS solution；
Centrifuge disk module, including centrifugal pan and the second drive mechanism for driving the centrifugation disc spins, the centrifugation
Disk is circumferentially equidistantly arranged with multiple reaction pipe holders, is provided with each reaction pipe holder at least one for placing
The reaction tube seat of reaction tube, the centrifugal pan are used to realize the centrifugation of filling liquid in the reaction tube, second driving
Mechanism is used to drive the centrifugal pan realization to rotate clockwise or counterclockwise and be accurately positioned；
Carriage movement module, is arranged on the top of sample introduction motion module, including the second single shaft driver, and described second
The clamp system for clamping reaction tube is provided with single shaft driver；The carriage movement module drives the clamp system edge
Moved on XYZ axle any directions, the reaction tube is transported into the centrifugal pan；
Second liquid relief arm module, including the second probe and the second machine mechanical arm for fixing the second probe, described second
Mechanical arm drives the second probe rotation and mobile, the supernatant that second probe is used for after suction centrifugation.
Specifically, being used to contain the sample in the sample tube, it is used to contain the antibody in the antibody pipe, it is described
Filling liquid in reaction tube is the sample, the antibody and the hemolysin or the sample, the antibody, described molten
The reaction solution that sanguinin and the PBS solution are formed.
Further, the first temperature controller is provided with the sample antibody moiety, temperature controlling range is 2 DEG C -8 DEG C；Institute
State and the second temperature controller is provided with reaction module, temperature control value is 37 DEG C.
Further, sample introduction motion module also includes the 3rd single shaft driver and the 4th single shaft driver, and described the
Three single shaft drivers are arranged on the 4th single shaft driver, are moved by the 4th single shaft driver drives edge X-direction, institute
State the first single shaft driver to be arranged on the 3rd single shaft driver, pass through the 3rd single shaft driver drives edge Y-axis side
To movement, the first single shaft driver drives the sample introduction needle to be moved along Z-direction.
Further, the carriage movement module also includes single axis robot and the 5th single shaft driver, and the described 5th is single
Axle driver is arranged on the single axis robot, is moved by single axis robot's drives edge X-direction, and described second is single
Axle driver is arranged on the 5th single shaft driver, is moved by the 5th single shaft driver drives edge Y direction, institute
Stating the second single shaft driver drives the clamp system to be moved along Z-direction.
As preferable, the first liquid relief arm module and the second liquid relief arm module are arranged on the side of the centrifugal pan,
The first mechanical arm and second mechanical arm during motion thereon is non-interference.
Further, the first liquid level inductor is also set up on the sample introduction motion module, for detecting the sample, antibody
With the liquid level of reaction solution in reaction tube.
Further, the second liquid level sensor is provided with the second mechanical arm, after being centrifuged for detection in reaction tube
The liquid level of supernatant.
Further, the system also includes cleaning module, the cleaning module include cleaning pump, syringe pump, magnetic valve,
Fluid path pipeline, service sink and cleaning fluid bucket, first probe and second probe are connected with the syringe pump respectively, described
Syringe pump is connected by the magnetic valve with the cleaning pump, and the cleaning pump intake is connected with the cleaning fluid bucket, described clear
Pump discharge is washed to be connected with the service sink by the fluid path pipeline.
Specifically, the service sink includes the first service sink, the second service sink and the 3rd service sink, a service sink is set
Put in the agent bin, second service sink is arranged on the side of the centrifugal pan, close to first probe；Described
Three service sinks are arranged on the opposite side of the centrifugal pan, close to second probe.
Using above-mentioned technical proposal, rail mounted system for pretreating sample of the present invention has the advantages that：
1) the shortcomings that rail mounted system for pretreating sample provided by the invention can be good at overcoming artificial treatment to bring,
Sample preparation can be performed automatically with full automation and modern method before flow cytometer and similar cell research；
2) there is rail mounted system for pretreating sample provided by the invention sample introduction to move module, can realize that XYZ axles are any
Movement on direction, drive sample introduction needle that sample and antibody are filled into reaction tube；
3) rail mounted system for pretreating sample provided by the invention has carriage movement module, can realize that XYZ axles are any
Movement on direction, drive clamp system to transport reaction tube in centrifugal pan and centrifuged.
Brief description of the drawings
Technical scheme in order to illustrate the embodiments of the present invention more clearly, make required in being described below to embodiment
Accompanying drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for
For those of ordinary skill in the art, on the premise of not paying creative work, other can also be obtained according to these accompanying drawings
Accompanying drawing.
Fig. 1 is the structural representation of rail mounted system for pretreating sample of the present invention；
Fig. 2 is the internal structure schematic diagram of rail mounted system for pretreating sample of the present invention；
Fig. 3 is the structural representation of sample introduction motion module；
Fig. 4 is the structural representation of carriage movement module；
Fig. 5 is the structural representation of the first liquid relief arm module；
Fig. 6 is the structural representation of sample antibody moiety module；
Fig. 7 is the structural representation of reaction module；
Fig. 8 is the structural representation for centrifuging disk module；
In figure, 1- agent bins, 11- sample antibody moieties, 111- sample box, 112- antibody boxes, 1111- sample tube seats,
1121- antibody tube seats, 12- reaction modules, 121- reaction boxes, 1211- reaction tube seats, the drive mechanisms of 122- first, 123- first
Cushioning support-saddle, 2- centrifugation disk modules, 21- centrifugal pans, 211 reaction pipe holders, 2111- reaction tube seats, the drive mechanisms of 22- second,
The cushioning support-saddles of 23- second, 3- sample introductions motion module, 31- the first single shaft drivers, 311- sample introduction needles, the driving of the single shafts of 32- the 3rd
Device, the single shaft drivers of 33- the 4th, 4- carriage movement modules, 41- the second single shaft drivers, 42- single axis robots, 43- the 5th are single
Axle driver, 411- clamp systems, 5- the first liquid relief arm modules, the probes of 51- first, 52- first mechanical arms, 53- first rotate
Drive mechanism, the moving drive mechanisms of 54- first, 55- first rotating shafts, 6- the second liquid relief arm modules, the probes of 61- second, 62- second
Mechanical arm, the rotary drive mechanisms of 63- second, the moving drive mechanisms of 64- second, the rotating shafts of 65- second, the service sinks of 7- first, 8-
Two service sinks, the service sinks of 9- the 3rd, 10- instrument hosts, 11- photoelectric sensors.
Embodiment
In order that those skilled in the art more fully understand the present invention program, below in conjunction with the embodiment of the present invention
Accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only
The embodiment of a part of the invention, rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill people
The every other embodiment that member is obtained under the premise of creative work is not made, it should all belong to the model that the present invention protects
Enclose.
" one embodiment " or " embodiment " referred to herein refers to may be included at least one implementation of the present invention
Special characteristic, structure or characteristic.In the description of the invention, it is to be understood that term " on ", " top ", " bottom ", etc. instruction
Orientation or position relationship be based on orientation shown in the drawings or position relationship, be for only for ease of the description present invention and simplification retouched
State, rather than instruction or imply signified device or element there must be specific orientation, with specific azimuth configuration and operation,
Therefore it is not considered as limiting the invention.In addition, term " first ", " second " are only used for describing purpose, without being understood that
To indicate or implying relative importance or the implicit quantity for indicating indicated technical characteristic.Thus, define " first ",
The feature of " second " can be expressed or what is implied includes one or more this feature.Moreover, term " first ", " second "
Etc. being for distinguishing similar object, without for describing specific order or precedence.It should be appreciated that so use
Data can exchange in the appropriate case, so that embodiments of the invention described herein can be with except illustrating or retouching herein
Order beyond those stated is implemented.
Embodiment one：
Can before flow cytometer and similar cell research the technical problem to be solved in the present invention is to provide one kind
The system for performing sample preparation automatically with full automation and modern method, and the shifting on XYZ axle any directions can be realized
It is dynamic, carry out filling sample, antibody and carry out reactant transport pipe.
In order to solve the above technical problems, the invention discloses a kind of rail mounted system for pretreating sample, such as Fig. 1 and Fig. 2 institutes
Show, the system for pretreating sample includes instrument host 10, and agent bin 1, the agent bin 1 are provided with the instrument host 10
Including spaced sample antibody moiety 11 and reaction module 12, as preferable, the reaction module 12 is arranged on described
The right side of sample antibody moiety 11.Further, as shown in figure 8, the sample antibody moiety 11 includes sample box 111 and antibody
Box 112, the sample tube seat 1111 for placing sample tube is arranged at intervals with the sample box 111；Between in the antibody box 112
Every being provided with the antibody tube seat 1121 for placing antibody pipe；The antibody box 112 is arranged on the side of the sample box 111,
As preferable, the sample box 111 and antibody box 112 are rectangle, and splice one big rectangle of composition, the sample
The interval of the horizontal direction in the sample box 111 of this tube seat 1111 is identical with the interval on longitudinal direction；The antibody tube seat
Interval between 1121 is identical with the interval between the sample tube seat 1111.As preferable, set in the sample box 111
There are 18 sample tube seats 1111, a sample tube is placed in each sample tube seat 1111,50- is contained in each sample tube
150 μ L blood sample；18 antibody tube seats 1121 are provided with the antibody box 112, one is placed in each antibody tube seat 1121
Individual antibody pipe, 5-25 μ L antibody is each contained in the antibody pipe,
Further, the first temperature controller (not shown), temperature control model are provided with the sample antibody moiety 11
Enclose for 2 DEG C；The second temperature controller (being to show in figure) is provided with the reaction module 12, temperature control value is 37 DEG C.
Further, as shown in fig. 7, the reaction module 12 is used for the incubation and mixing for realizing sample and antibody；It is described
Reaction module 12 includes reaction box 121, and the reaction tube seat for placing response pipe is arranged at intervals with the reaction box 121
1211；As preferable, one reaction tube of placement in each reaction tube seat 1211, it is used to contain the sample in the reaction tube
With the reaction solution of the antibody.The lower section of reaction box 121 is provided with the first drive mechanism 122 and the first cushioning support-saddle 123, makees
To be preferable, first drive mechanism 122 is servomotor.As preferable, the servomotor is with 300r/min speed
Degree rotation, makes reaction box 121 under this rotating speed and is steadily shaken in the presence of the first cushioning support-saddle 123, by sample and antibody
Mixed in reaction tube.
Further, the top of the agent bin 1 is provided with sample introduction motion module 3；The sample introduction motion module 3 can be real
Movement on existing XYZ axle any directions.Specifically, as shown in figure 3, sample introduction motion module 3 includes the first single shaft driver
31st, the 3rd single shaft driver 32 and the 4th single shaft driver 33, the 4th single shaft driver 33 are arranged on instrument host 10
In side wall, the 3rd single shaft driver 32 is arranged on the 4th single shaft driver 33, the 4th single shaft driver 33
For driving the 3rd single shaft driver 32 to be moved along X-direction, the first single shaft driver 31 is arranged on the described 3rd
On single shaft driver 32, the 3rd single shaft driver 32 is used to drive the first single shaft driver 31 to move along Y direction；
Further, sample introduction needle 311 is provided with the first single shaft driver 31, the sample introduction needle 311 is arranged on by connector
On first sliding block, the first single shaft driver drives the sample introduction needle 311 direction along Z to move by driving sliding block mobile
It is dynamic.Specifically, the sample introduction motion module 3 is moved the sample tube by driving the sample introduction needle 311 on XYZ direction of principal axis
In blood sample and antibody pipe in antibody be filled into reaction tube, so as to carried out in reaction tube the incubation of sample and antibody and
Mix.
Further, the first single shaft driver 31, the 3rd single shaft driver 32 and the 4th single shaft driver 33 are logical
Cross driving stepper motor.It is right on the first single shaft driver 31, the 3rd single shaft driver 32 and the 4th single shaft driver 33
Title is provided with photoelectric sensor 11, and as preferable, 2 photoelectric sensors 11 are symmetrically arranged with each single shaft driver.
Further, the system also includes cleaning module, and the cleaning module includes cleaning pump (not shown), note
Penetrate pump (not shown), magnetic valve (not shown), fluid path pipeline (not shown), service sink and cleaning fluid bucket (figure
Not shown in), first probe and second probe are connected with the syringe pump respectively, and the syringe pump passes through the electricity
Magnet valve is connected with the cleaning pump, and the cleaning pump intake is connected with the cleaning fluid bucket, and the cleaning pump discharge passes through described
Fluid path pipeline is connected with the service sink.
Specifically, as depicted in figs. 1 and 2, the service sink includes the first service sink 7, the second service sink 8 and the 3rd cleaning
Pond 9, first service sink 7 are arranged in agent bin 1, and as preferable, first service sink 7 is arranged on the sample and resisted
In the clearance space of module 11 and reaction module 12.The sample introduction needle 311 is led to after having drawn sample and being filled into reaction tube
Cross sample introduction motion module 3 move in the first service sink 7 cleaned after carry out again antibody absorption filling, often complete once plus
Note all samples carry out the cleaning of sample introduction needle 311, avoid cross pollution, and as preferable, cross pollution rate control is existed
Within 0.05%.
As preferable, the sample introduction needle 311 has anti-collision, when the sample introduction needle 311 is by vertical direction
It can be automatically stopped when resistance or shock, and send alarm signal.It is worth noting that, the internal diameter of the sample introduction needle 311 should not be too
Greatly also should not be too small, if excessive, the precision of antibody described in compressing can be caused to be forbidden；If too small, blood sample described in compressing can be caused
Less cleaning position and stifled pin afterwards.In order to avoid the waste of the blood sample and antibody, the sample introduction motion module 3 enters described in
The first liquid level sensor (not shown) is provided with the position of sample pin 311, for sample tube described in automatic detection and antibody
The liquid level of sample and antibody in pipe, ensure that the antibody at utmost blots.
Further, the system also includes the first liquid relief arm module 5, specifically, as shown in figure 5, first liquid relief
Arm film block 5 is also disposed on the machine of instrument master 10, including the first probe 51 and for fixing first probe 51 first
Mechanical arm 52；Specifically, the first mechanical arm 52 is arranged on the first rotary drive mechanism 53 by first rotating shaft 55, pass through
First sliding module is arranged on the first moving drive mechanism 54.The first mechanical arm 52 drives first probe 51 in institute
State and rotated under the driving of the first rotary drive mechanism 55, moved under the driving of first moving drive mechanism 54；Preferably,
The first mechanical arm 52 has positional fault warning function, when positional fault occurs in the motion process of first mechanical arm 52
When, send alarm signal.First probe 51 is used to fill hemolysin and PBS solution.Preferably, first probe 51 has
There is anti-collision, can be automatically stopped when resistance or shock of first probe 51 by vertical direction, and send alarm
Signal.
Further, the system also includes centrifugation disk module 2, and the centrifugation disk module 2 is used to realize the reaction tube
The centrifugation of filling liquid.Specifically, as shown in figure 8, it is described centrifugation disk module 2 be also disposed on the instrument host 10, wrap
Centrifugal pan 21 and the second drive mechanism 22 for driving the centrifugal pan 21 to rotate are included, as preferable, second driving
Mechanism 22 is servomotor, and the rotating speed of servomotor is controlled in 23000r/min, drives the centrifugal pan 21 to rotate, and pass through
Be arranged on the second cushioning support-saddle 23 control vibration amplitude of the bottom of centrifugal pan 21, velocity variations when avoiding startup and shutdown it is big and
Cause strenuous vibration.The centrifugal pan 21 is circumferentially equidistantly arranged with 18 reaction pipe holders 211, each reaction tube branch
2 reaction tube seats 2111 for being used for placing response pipe are provided with frame 211, each react places a reaction in tube seat 2111
Pipe.
Further, the system changes the top for including carriage movement module 4, being arranged on the sample introduction motion module 3；Tool
Body, driven as shown in figure 4, the carriage movement module 4 includes single axis robot 42, the second single shaft driver 41 and the 5th single shaft
Dynamic device 43, the single axis robot 42 are arranged in the side wall of the instrument host 10, and the 5th single shaft driver 43 is set
On the single axis robot 42, the single axis robot 42 drives the 5th single shaft driver 43 to be moved along X-direction, institute
State the second single shaft driver 41 to be arranged on the 5th single shaft driver 43, the 5th single shaft driver 43 drives described
Two single shaft drivers 41 move along Y direction；Further, it is provided with the second single shaft driver 41 for clamping reaction
The clamp system 411 of pipe, the second single shaft driver 41 drive the clamp system 411 to move in the Z-axis direction.Specifically
, the carriage movement module 4 drives the clamp system 411 to be moved on XYZ axle any directions, by reaction tube transport to from
In cartridge 21.Specifically, in the present embodiment, the reaction of sample and antibody mixing liquid will be loaded with by carriage movement module 4
After pipe moves to an off cartridge 21, hemolysin is filled by the first probe 51 on the first liquid relief arm 5, after filling, opens centrifugal pan
Centrifugation.
Further, the single axis robot 42, the second single shaft driver 41 and the 5th single shaft driver 43 pass through step
Stepper motor drives.It is symmetrically arranged with the single axis robot 42, the second single shaft driver 41 and the 5th single shaft driver 43
Photoelectric sensor 11, as preferable, 2 photoelectric sensors 11 are symmetrically arranged with each single shaft driver.
Further, the system also includes the second liquid relief arm module 6, specifically, the second liquid relief arm film block 6 is also set
Put on the instrument host 10, including the second probe 61 and the second mechanical arm 62 for fixing second probe 61；Tool
Body, the second mechanical arm 62 is arranged on the second rotary drive mechanism 63 by the second rotating shaft 65, passes through the second sliding die
Group is arranged on the second moving drive mechanism 64.The second mechanical arm 62 drives second probe 61 in the described second rotation
Rotate under the driving of drive mechanism 62, moved under the driving of second moving drive mechanism 64；Preferably, second machine
Tool arm 62 has positional fault warning function, when positional fault occurs in the motion process of second mechanical arm 62, sends report
Alert signal.Second probe 64 is used to aspirate the supernatant after centrifugation.Specifically, above-mentioned blood sample, antibody and hemolysin mix
The supernatant after liquid centrifugation is closed after second probe suction, continues through the first probe 51 filling PBS solution, filling is follow-up
Continuous centrifugation suction supernatant.Preferably, second probe 61 has anti-collision, when second probe 61 is by vertical
It can be automatically stopped when the resistance in direction or shock, and send alarm signal.
As preferable, by repeatedly filling PBS solution, and suction supernatant carrys out purification of liquid after centrifuging.
As preferable, the first liquid relief arm module 5 and the second liquid relief arm module 6 are arranged on the one of the centrifugal pan 21
Side, the first mechanical arm 52 and second mechanical arm 62 during motion thereon are non-interference.
Further, the second liquid level sensor (not shown) is provided with the second mechanical arm 62, for automatic
The liquid level of supernatant in the reaction tube is detected, ensures that second probe 62 possesses delineation under side when sucting clear liquid and taken out
Function is inhaled, avoids the second probe 62 and the supernatant contact too deep, causes second probe 62 in the bad cleaning of service sink.
Further, second service sink 8 is arranged on the side of the centrifugal pan 21, close to first probe 51；
3rd service sink 9 is arranged on the opposite side of the centrifugal pan, close to second probe 61；First probe 51 is every
Second service sink 8 will be returned after secondary use to clean once, second probe 61 will return described after each
Three service sinks 9 are cleaned once, and so as to avoiding cross pollution to greatest extent, as preferable, the control of cross pollution rate is existed
In the range of 0.05%.
The sample processing system also includes operational control module, and the operational control module is used to control the sample to resist
Module module, the centrifugation disk module, the sample introduction motion module, the carriage movement module, the first liquid relief arm mould
The action of block and the second liquid relief arm module.Specifically, the operational control module includes touch-screen and control computer (figure
Not shown in), the control computer provides control program for each module in the system for pretreating sample, and passes through touch
Screen realizes operational control, to control whole sample process process.
Specifically, the sample process process in above-described embodiment can be summarized as following steps：Add antibody → heal sample →
Incubation → mixing → solubilization sanguinin → centrifuges → drawn up clear liquid → plus PBS solution → centrifuge → draw up clear liquid → plus PBS solution →
Centrifuge → draw up clear liquid → plus PBS solution.It is understood that it can repeatedly fill PBS solution.
Embodiment two：
Present embodiment discloses a kind of rail mounted system for pretreating sample, unlike embodiment one, in the present embodiment,
As depicted in figs. 1 and 2, the system for pretreating sample includes agent bin 1, and the agent bin 1 is arranged on instrument host 10, bag
Include spaced sample antibody moiety 11 and reaction module 12；
The sample antibody moiety 11 includes sample box 111 and antibody box 112, is arranged at intervals with the sample box 111
For placing the sample tube seat 1111 of sample tube；The antibody pipe for placing antibody pipe is arranged at intervals with the antibody box 112
Groove 1121；The antibody box 112 is arranged on the side of the sample box 111；As preferable, set in the sample box 111
There are 12 sample tube seats 1111, a sample tube is placed with each sample tube seat 1111,60- is loaded with each sample tube
120 μ L sample of blood sheets；12 antibody tube seats 1121 are provided with the antibody box 112, one is placed in each antibody tube seat 1121
Antibody pipe, 10-20 μ L antibody is loaded with each antibody pipe.As preferable, it is provided with the sample antibody moiety 11
First temperature controller (not shown), temperature control are provided with the second temperature controller (in figure not at 8 DEG C on the reaction module 12
Show), temperature control is at 37 DEG C.
Further, the reaction module 12 is used for the incubation and mixing for realizing sample and antibody, including reaction box 121,
The reaction tube seat 1211 for placing response pipe is arranged at intervals with the reaction box 121, as preferable, the reaction box
24 reaction tube seats 1211 are provided with 121, each react places a reaction tube in tube seat 1211.Further, it is described anti-
The lower section of box 121 is answered to be provided with the first drive mechanism 122, as preferable, first drive mechanism 122 be servomotor, turn
Speed is 250r/min, and the reaction box 121 rotates under the driving of the first drive mechanism 122, and in the first cushioning support-saddle 123
The steady vibrations of effect.
Further, the system also includes centrifugation disk module 2, and the centrifugation disk module 2 includes centrifugal pan 21 and is used for
The second drive mechanism 22 for driving the centrifugal pan 21 to rotate, the centrifugal pan 21 are circumferentially equidistantly arranged with 24 reaction tubes
Support 211, each described react are provided with 1 reaction tube seat 2111 for being used for placing response pipe on pipe holder 211, each reaction
1 reaction tube is placed in tube seat 2111, the centrifugal pan 21 is used to realize the centrifugation of filling liquid in the reaction tube, as
Preferably, second drive mechanism 22 is servomotor, rotating speed 2500r/min；Used by second drive mechanism 22
Rotate clockwise or counterclockwise and be accurately positioned in driving the centrifugal pan 21 to realize, and in the presence of the second cushioning support-saddle 23
Realize steady vibrations.
In the present embodiment, the sample process process comprises the following steps：Antibody → healing sample → incubation → is added to mix
Even → solubilization sanguinin → centrifuges → drawn up clear liquid and → add PBS solution → to centrifuge → draw up clear liquid → plus PBS solution → to centrifuge → take out
Supernatant → plus PBS solution.
Specifically, in the present embodiment, sample introduction needle 311 in module 3 is moved by the blood in sample tube by sample introduction first
Antibody in sample and antibody pipe is filled into reaction tube of the reaction with, and passes through the clamp system in carriage movement module 4
411 transport reaction tube in centrifugal pan 21；Reaction tube is transported after centrifugal pan 21 again by first in the first liquid relief arm 5
Probe 51 fills hemolysin into reaction tube, and later on centrifugal pan 21 centrifuges.Pass through second in the second liquid relief arm 6 after centrifugation
Supernatant after the suction centrifugation of probe 61, then fills PBS solution by the first probe 51 again.It is understood that above-mentioned step
In rapid, by centrifuging and taking supernatant after repeatedly filling PBS solution come purification of liquid.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (10)
- A kind of 1. rail mounted system for pretreating sample, it is characterised in that including：Agent bin (1), including spaced sample antibody moiety (11) and reaction module (12), the sample antibody moiety (11) include sample box (111) and antibody box (112), be arranged at intervals with the sample box (111) for placing sample tube Sample tube seat (1111)；The antibody tube seat (1121) for placing antibody pipe is arranged at intervals with the antibody box (112)；It is described Antibody box (112) is arranged on the side of the sample box (111)；The reaction module (12), for realizing the incubation and mixing of sample and antibody, including reaction box (121), the reaction The reaction tube seat (1211) for placing response pipe is arranged at intervals with box (121), the is provided with below the reaction box (121) One drive mechanism (122), the reaction box (121) rotate under the driving of the first drive mechanism (122)；Sample introduction moves module (3), including the first single shaft driver (31), is provided with and is used on the first single shaft driver (31) The sample introduction needle (311) of sample and antibody is filled into the reaction tube, the sample introduction motion module (3) drives the sample introduction needle (311) moved along XYZ axle any directions, the sample and antibody are filled into the reaction tube；First liquid relief arm module (5), including the first probe (51) and the first mechanical arm for fixing first probe (51) (52), the first mechanical arm (52) drives the first probe (51) rotation and mobile, first probe (51) be used for Hemolysin and PBS solution are filled in the reaction tube；Centrifuge disk module (2), including centrifugal pan (21) and the second drive mechanism for driving the centrifugal pan (21) to rotate (22), the centrifugal pan (21) is circumferentially equidistantly arranged with multiple reaction pipe holders (211), each reaction pipe holder (211) at least one reaction tube seat (2111) for placing response pipe is provided with, the centrifugal pan (21) is used to realize institute The centrifugation of filling liquid in reaction tube is stated, second drive mechanism (22) is used to drive the centrifugal pan (21) to realize up time Pin is rotated counterclockwise and is accurately positioned；Carriage movement module (4), it is arranged on the top of the sample introduction motion module (3), including the second single shaft driver (41), institute State the clamp system (411) being provided with the second single shaft driver (41) for clamping reaction tube；The carriage movement module (4) Drive the clamp system (411) to be moved along XYZ axle any directions, the reaction tube is transported to the centrifugal pan (21) In；Second liquid relief arm module (6), including the second probe (61) and the second machine mechanical arm for fixing the second probe (61) (62), the second mechanical arm (62) drives the second probe (61) rotation and movement, and second probe (61) is used to take out It is sucked away from the supernatant after the heart.
- 2. rail mounted system for pretreating sample according to claim 1, it is characterised in that be used to contain in the sample tube The sample, is used to containing the antibody in the antibody pipe, and the filling liquid in the reaction tube is the sample, described The reaction solution that antibody and the hemolysin or the sample, the antibody, the hemolysin and the PBS solution are formed.
- 3. rail mounted system for pretreating sample according to claim 1 or 2, it is characterised in that the sample antibody moiety (11) the first temperature controller is provided with, temperature controlling range is 2 DEG C -8 DEG C；The second temperature control is provided with the reaction module (12) Device, temperature control value are 37 DEG C.
- 4. rail mounted system for pretreating sample according to claim 1, it is characterised in that the sample introduction motion module (3) Also include the 3rd single shaft driver (32) and the 4th single shaft driver (33), the 3rd single shaft driver (32) is arranged on described On 4th single shaft driver (33), moved by the 4th single shaft driver (33) drives edge X-direction, the first single shaft driving Device (31) is arranged on the 3rd single shaft driver (32), passes through the 3rd single shaft driver (32) the drives edge Y direction Mobile, the first single shaft driver (31) drives the sample introduction needle (311) to be moved along Z-direction.
- 5. rail mounted system for pretreating sample according to claim 1, it is characterised in that the carriage movement module (4) Also include single axis robot (42) and the 5th single shaft driver (43), the 5th single shaft driver (43) is arranged on the single shaft In robot (42), moved by the single axis robot (42) drives edge X-direction, the second single shaft driver (41) sets Put on the 5th single shaft driver (43), moved by the 5th single shaft driver (43) the drives edge Y direction, it is described Second single shaft driver (41) drives the clamp system (411) to be moved along Z-direction.
- 6. rail mounted system for pretreating sample according to claim 1, it is characterised in that the first liquid relief arm module (5) and the second liquid relief arm module (6) is arranged on the side of the centrifugal pan (21), first mechanical arm during motion thereon (52) and second mechanical arm (62) is non-interference.
- 7. the rail mounted system for pretreating sample according to claim 1 or 4, it is characterised in that the sample introduction moves module (3) the first liquid level inductor is also set up on, for detecting the liquid level of reaction solution in the sample, antibody and reaction tube.
- 8. the rail mounted system for pretreating sample according to claim 1 or 6, it is characterised in that the second mechanical arm (62) the second liquid level sensor is provided with, the liquid level for supernatant in reaction tube after detection centrifugation.
- 9. rail mounted system for pretreating sample according to claim 1, it is characterised in that the system also includes cleaning mould Block, the cleaning module include cleaning pump, syringe pump, magnetic valve, fluid path pipeline, service sink and cleaning fluid bucket, and described first visits Pin and second probe are connected with the syringe pump respectively, and the syringe pump is connected by the magnetic valve and the cleaning pump Connect, the cleaning pump intake is connected with the cleaning fluid bucket, and the cleaning pump discharge passes through the fluid path pipeline and the cleaning Pond connects.
- 10. rail mounted system for pretreating sample according to claim 9, it is characterised in that the service sink includes first Service sink (7), the second service sink (8) and the 3rd service sink (9), first service sink (7) are arranged on the agent bin (1) In, second service sink (8) is arranged on the side of the centrifugal pan (21), close to first probe (51)；Described 3rd Service sink (9) is arranged on the opposite side of the centrifugal pan (21), close to second probe (61).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710689623.8A CN107422138A (en) | 2017-08-14 | 2017-08-14 | A kind of rail mounted system for pretreating sample |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710689623.8A CN107422138A (en) | 2017-08-14 | 2017-08-14 | A kind of rail mounted system for pretreating sample |
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| CN201710689623.8A Pending CN107422138A (en) | 2017-08-14 | 2017-08-14 | A kind of rail mounted system for pretreating sample |
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| CN108593950A (en) * | 2018-03-26 | 2018-09-28 | 中国科学院苏州生物医学工程技术研究所 | A kind of liquid automatic sample feeding device |
| CN109612799A (en) * | 2018-12-27 | 2019-04-12 | 杨永俊 | Glass slide automatic analyzer |
| CN110579436A (en) * | 2019-09-25 | 2019-12-17 | 重庆微浪生物科技有限公司 | flow cytometry workstation |
| CN111744864A (en) * | 2020-07-13 | 2020-10-09 | 哈尔滨跃渊环保智能装备有限责任公司 | Syringe wiper mechanism and water quality testing equipment of water quality testing equipment |
| CN112730867A (en) * | 2021-01-21 | 2021-04-30 | 深圳唯公生物科技有限公司 | Sample preparation device and preparation method of flow analyzer |
| CN116174073A (en) * | 2023-05-04 | 2023-05-30 | 合肥机数量子科技有限公司 | Automatic high-precision liquid sample injection system and method |
| CN118707120A (en) * | 2024-08-28 | 2024-09-27 | 北京众驰伟业科技发展有限公司 | Abnormal alarm automatic retest coagulation tester |
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| CN118707120A (en) * | 2024-08-28 | 2024-09-27 | 北京众驰伟业科技发展有限公司 | Abnormal alarm automatic retest coagulation tester |
| CN118707120B (en) * | 2024-08-28 | 2024-10-29 | 北京众驰伟业科技发展有限公司 | Abnormal alarm automatic retest coagulation tester |
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Application publication date: 20171201 |