CN107412319A - A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound - Google Patents
A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound Download PDFInfo
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- CN107412319A CN107412319A CN201710409338.6A CN201710409338A CN107412319A CN 107412319 A CN107412319 A CN 107412319A CN 201710409338 A CN201710409338 A CN 201710409338A CN 107412319 A CN107412319 A CN 107412319A
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- enoxolone
- resin
- filtering
- glycyrrhizic acid
- efficiency reduces
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 title claims abstract description 17
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 229960003720 enoxolone Drugs 0.000 title claims abstract description 17
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 title claims abstract description 14
- -1 liquorice flavonoids compound Chemical class 0.000 title claims abstract description 13
- 244000303040 Glycyrrhiza glabra Species 0.000 title claims abstract description 12
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 title claims abstract description 12
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 229930003935 flavonoid Natural products 0.000 title claims abstract description 12
- 235000017173 flavonoids Nutrition 0.000 title claims abstract description 12
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 229960004949 glycyrrhizic acid Drugs 0.000 title claims abstract description 12
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 239000001685 glycyrrhizic acid Substances 0.000 title claims abstract description 12
- 235000019410 glycyrrhizin Nutrition 0.000 title claims abstract description 12
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 title claims abstract description 12
- 235000011477 liquorice Nutrition 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000011347 resin Substances 0.000 claims abstract description 23
- 229920005989 resin Polymers 0.000 claims abstract description 23
- 238000001914 filtration Methods 0.000 claims abstract description 10
- 239000000047 product Substances 0.000 claims abstract description 9
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000003456 ion exchange resin Substances 0.000 claims abstract description 8
- 229920003303 ion-exchange polymer Polymers 0.000 claims abstract description 8
- 239000002250 absorbent Substances 0.000 claims abstract description 6
- 230000002745 absorbent Effects 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000003513 alkali Substances 0.000 claims abstract description 5
- 230000033228 biological regulation Effects 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 239000003463 adsorbent Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims 1
- 238000012797 qualification Methods 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 150000002500 ions Chemical class 0.000 description 5
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 206010041277 Sodium retention Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of efficiency to reduce the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, and a certain amount of macroporous absorbent resin or ion exchange resin are added in alcohol extract, stirs 5min, stand more than 16h, filtering, filtrate are condensed into medicinal extract, add alkali lye, stand more than 24h, filtering, filtrate add hydrochloric acid regulation pH value to be 5, filtering, it is 7 that filter residue, which is washed to pH value, and filter residue and drying is got product.Present invention reduces content of the glycyrrhetic acid content without reducing active ingredient, product qualification rate is substantially increased, qualification rate is by original 32% to 98%.
Description
Technical field
Reduced the present invention relates to chemistry, chemical technology field, more particularly to a kind of efficiency sweet in liquorice flavonoids compound
The method of oxalic acid and enoxolone.
Background technology
Liquorice flavonoids compound has the effect such as antitumor, anti-inflammatory, anti-oxidant, anti-arrhythmia, liver protection.From radix glycyrrhizae or
When liquorice flavonoids compound is extracted in glycyrrhiza extract, part glycyrrhizic acid and enoxolone, glycyrrhizic acid and radix glycyrrhizae are often extracted
Hypo acid may cause the side effects such as water-sodium retention after being taken in by human body, therefore glycyrrhizic acid and enoxolone are usually listed in radix glycyrrhizae
Limitation in flavone compound medicine checks part.
Macroreticular resin (macroporous resin) is also known as full porous resin, is using styrene and propionic ester as monomer, adds
It is crosslinking agent to enter Ethenylbenzene, and toluene, dimethylbenzene are pore-foaming agent, and their polymerizations that are cross-linked with each other form porous skeleton structure.Resin
Generally white spherical particle, granularity be 20~60 mesh, is the cross-linked polymer of one kind group containing ion exchange, its physics and chemistry
Property is stable, insoluble in acid, alkali and organic solvent, is not influenceed by inorganic salts and strong ion low molecular compound.Resin is inhaled
Attached effect is the Van der Waals force for relying on it between adsorbed molecule (adsorbate), passes through its huge ratio surface and carries out thing
Reason is adsorbed and worked, and organic compound is reached according to having absorption affinity and its molecular size range to be separated through the elution of certain solvent
To different purposes such as separation, purifying, removal of impurities, concentrations.
Ion exchange resin is with functional group's (active group for having exchange ion), has network structure, insoluble
High-molecular compound.The species of chemical active radical determines the main character and classification of resin, these active groups in resin
It is to exchange functional group, some cations (such as H+ or Na+) or anion (such as OH- or Cl-) can be dissociated in the solution, together
When adsorbent solution in other cations or anion for having originally.Ion i.e. in resin mutually intersects with the ion in solution
Change, so as to which the ion isolation in solution be come out.
The content of the invention
It is an object of the invention to provide a kind of efficiency to reduce glycyrrhizic acid and enoxolone in liquorice flavonoids compound
Method：
A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, comprises the following steps：
A certain amount of macroporous absorbent resin or ion exchange resin are added in alcohol extract, stirs 5min, stands more than 16h, is filtered, filtrate is dense
Shorten medicinal extract into, add alkali lye, stand more than 24h, filtering, filtrate adds hydrochloric acid regulation pH value to be 5, and filtering, filter residue is washed to pH value and is
7, filter residue and drying is got product.
Preferably, macroporous absorbent resin or ion exchange resin addition are 10 grams.
Preferably, model ADS-7, ADS-F8 or LX-16 of the macroporous absorbent resin.
The beneficial effects of the invention are as follows：Content present invention reduces glycyrrhetic acid content without reduction active ingredient, greatly
Product qualification rate is improved greatly, qualification rate is by original 32% to 98%.
Embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
Only part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belong to the model that the present invention protects
Enclose.
A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, comprises the following steps：
A certain amount of macroporous absorbent resin or ion exchange resin are added in alcohol extract, stirs 5min, stands more than 16h,
Filtering, filtrate are condensed into medicinal extract, add alkali lye, stand more than 24h, filtering, and filtrate adds hydrochloric acid regulation pH value to be 5, filtering, filter residue water
It is 7 to be washed till pH value, and filter residue and drying is got product.Content present invention reduces glycyrrhetic acid content without reduction active ingredient,
Product qualification rate is substantially increased, qualification rate is by original 32% to 98%.
8 kind (1 is added in alcohol extract by the above method:XDA-1、2:ADS-7、3:ADS-F8、4:XDA-8、5:LX-
16、6:LX-162、7:LX-T19、8:LX-201) resin of different model is numbered by natural number respectively, and 1-6 resins are macropore
Polymeric adsorbent, 7-8 resins are ion exchange resin, and resin amount is 10g, the final products through 1-8 resin treatments
Enoxolone reduces by 14.7%, 38.0%, 30.1%, 59.2%, 51.6%, 17.8%, 69.3%, 80.0% respectively, but produces
Product active ingredient reduces by 38.5%, 22.9%, 23.2%, 62.8%, 39.5%, 19.7%, 64.8%, 80.1 respectively, synthesis
Consider that choosing enoxolone reduces the resin that amplitude is more than active ingredient attenuating amplitude, therefore preferably No. 2, No. 3, No. 5 resin types
Number it is optimal.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (3)
1. a kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, it is characterised in that including such as
Lower step：A certain amount of macroporous absorbent resin or ion exchange resin are added in alcohol extract, stirs 5min, stands more than 16h, mistake
Filter, filtrate are condensed into medicinal extract, add alkali lye, stand more than 24h, filtering, and filtrate adds hydrochloric acid regulation pH value to be 5, filtering, filter residue washing
It is 7 to pH value, filter residue and drying is got product.
2. a kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, it is characterised in that macropore is inhaled
Attached resin or ion exchange resin addition is 10 grams.
3. a kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, it is characterised in that described big
Model ADS-7, ADS-F8 or LX-16 of macroporous adsorbent resin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710409338.6A CN107412319A (en) | 2017-06-02 | 2017-06-02 | A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710409338.6A CN107412319A (en) | 2017-06-02 | 2017-06-02 | A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107412319A true CN107412319A (en) | 2017-12-01 |
Family
ID=60429485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710409338.6A Pending CN107412319A (en) | 2017-06-02 | 2017-06-02 | A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107412319A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114018A (en) * | 2018-01-18 | 2018-06-05 | 新疆乌拉尔甘草开发有限责任公司 | A kind of method for preparing alcohol-soluble licoflavone |
| CN113105423A (en) * | 2021-03-05 | 2021-07-13 | 新疆全安药业股份有限公司 | Method for extracting licoflavone by controlling glycyrrhizic acid content |
Citations (5)
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|---|---|---|---|---|
| CN1563073A (en) * | 2004-04-06 | 2005-01-12 | 南开大学 | Method for preparing enoxolone |
| CN101747307A (en) * | 2009-12-22 | 2010-06-23 | 江苏天晟药业有限公司 | Glycyrrhizic acid removal glycyrrhiza flavonoid and medicament composition thereof |
| CN102453075A (en) * | 2010-10-26 | 2012-05-16 | 曾科 | Separation and purification process of glycyrrhizic acid |
| CN102836202A (en) * | 2012-09-18 | 2012-12-26 | 波拉提·马卡比力 | A method for comprehensive development and utilization of aboveground parts of licorice |
| CN106619798A (en) * | 2016-12-27 | 2017-05-10 | 新疆全泰兴药业科技有限公司 | Extracting process of licorice flavonoid compound |
-
2017
- 2017-06-02 CN CN201710409338.6A patent/CN107412319A/en active Pending
Patent Citations (5)
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|---|---|---|---|---|
| CN1563073A (en) * | 2004-04-06 | 2005-01-12 | 南开大学 | Method for preparing enoxolone |
| CN101747307A (en) * | 2009-12-22 | 2010-06-23 | 江苏天晟药业有限公司 | Glycyrrhizic acid removal glycyrrhiza flavonoid and medicament composition thereof |
| CN102453075A (en) * | 2010-10-26 | 2012-05-16 | 曾科 | Separation and purification process of glycyrrhizic acid |
| CN102836202A (en) * | 2012-09-18 | 2012-12-26 | 波拉提·马卡比力 | A method for comprehensive development and utilization of aboveground parts of licorice |
| CN106619798A (en) * | 2016-12-27 | 2017-05-10 | 新疆全泰兴药业科技有限公司 | Extracting process of licorice flavonoid compound |
Non-Patent Citations (2)
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|---|
| 王巧娥等: "《甘草深加工技术》", 31 January 2011, 中国轻工业出版社 * |
| 第7期: "基于熵权法的多目标筛选甘草黄酮类成分纯化工艺", 《中草药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114018A (en) * | 2018-01-18 | 2018-06-05 | 新疆乌拉尔甘草开发有限责任公司 | A kind of method for preparing alcohol-soluble licoflavone |
| CN113105423A (en) * | 2021-03-05 | 2021-07-13 | 新疆全安药业股份有限公司 | Method for extracting licoflavone by controlling glycyrrhizic acid content |
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Application publication date: 20171201 |