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CN107402070B - A kind of skin high spectrum image acquisition unit and scaling method - Google Patents

A kind of skin high spectrum image acquisition unit and scaling method Download PDF

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Publication number
CN107402070B
CN107402070B CN201710407363.0A CN201710407363A CN107402070B CN 107402070 B CN107402070 B CN 107402070B CN 201710407363 A CN201710407363 A CN 201710407363A CN 107402070 B CN107402070 B CN 107402070B
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Prior art keywords
acquisition
light source
spectrum image
high spectrum
skin
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CN107402070A (en
Inventor
陈威
王学凯
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Ai De Ghosn Medical Technology (beijing) Co Ltd
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Ai De Ghosn Medical Technology (beijing) Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/2823Imaging spectrometer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0256Compact construction
    • G01J3/0259Monolithic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G01J2003/102Plural sources
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J2003/2866Markers; Calibrating of scan

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The present invention relates to skin high spectrum image acquisition process field more particularly to a kind of acquisition units and scaling method of skin high spectrum image.Including power supply, light source assembly, EO-1 hyperion camera, it is optically isolated cover;Described be optically isolated on cover is provided with an acquisition hole, and light source assembly and the setting of EO-1 hyperion camera are optically isolated in cover described;It takes pictures through EO-1 hyperion camera under the irradiation of the light source assembly by acquisition hole and obtains skin high spectrum image in dermal harvest region;The power supply unit connection light source assembly is powered for it;It further include having reference substance component;Realize correction of the skin spectrum image to acquisition in planar dimensions and spectral Dimensions.The present invention improves the accuracy of system by noise-reducing design;The consistency that ensure that the acquisition spectroscopic data in acquisition plane, every time between acquisition and distinct device, solves consistency problem.And solve acquisition hole and determine area (30mmx25mm) interior uniform illumination, so that system is provided with morphological analysis ability.

Description

A kind of skin high spectrum image acquisition unit and scaling method
Technical field
The present invention relates to skin high spectrum image acquisition process field more particularly to a kind of acquisitions of skin high spectrum image Unit and scaling method.
Background technique
" skin spectrum prediction " model proposes its virtual skin spectrum of combination by several material composition different content Mathematical method.Hereby model can render the visual effect of skin, and herein, we term it positive relationships.And " skin Skin EO-1 hyperion quantitative analysis " is then the reverse process of " skin spectrum prediction ", i.e., calculates skin by the measure spectrum of application on human skin Biological component content.Obviously, reverse process is the iteration optimization problem of positive relationship, needs to solve the essence being applicable in scene Quasi- modeling and flood tide computing technique.For quantitative analysis class medical instrument, key index is the accuracy and speed calculated, and can Reach the requirement of clinical application.
Hyper-spectral image technique differentiated in a manner of noninvasive, non-contacting skin biological component message context have it is only Special advantage.
Skin high-spectrum seems based on collected under visible light (400-700nm), spacing light path system design condition. What is got by EO-1 hyperion equipment is a data cube, not only has the image information of certain area, and in spectral Dimensions On be unfolded, as a result can not only obtain the spectroscopic data of each point on image, the image of any one spectral coverage can also be obtained Information.Since spectral resolution has reached nm grades (several nm), it can sufficiently, meticulously reflect the spy of its biological component Sign presents the characteristic of " jljl difference is not composed, and jljl is centainly with spectrum ", has substance and " refer on the full spectral coverage of visible light The effectiveness of line ", and the nuance of similar target can be distinguished, it can be used as the Research foundation of quantitative analysis.Compared to mostly light Spectrum, it has the simulation accuracy of full spectral coverage, eliminates " foreign matter is with spectrum " and " same object different images " phenomenon;Compared to single-point spectrum, It has morphological analysis ability, avoids single-point specificity and operate the strong point for requiring harshness to acquisition, for spectrum number Possibility is provided according to more efficiently analysis processing is carried out.However, since the different performance of target optical spectrum and combination can be with It is converted into different features, needs to establish the mathematical model comprising complete biological component, various dimensions, can realize all-wave Section emulation, fine fitting.
Light source used by visible light wave range (400-700) is mostly tungsten lamp class light source under normal circumstances.But tungsten light source exists The spectrum spoke of 400-500nm range of wavelengths is lower by force, and signal-to-noise ratio is relatively low, leads to the error based on EO-1 hyperion skin quantitative analysis It is bigger, it is difficult to the basis signal as quantitative analysis.
Hyper-spectral image technique is on the actual application not yet in skin analysis field.Traditional skin analysis is mainly adopted It is analyzed with tissue morphology pathology method, skin is invasive acquisition, and general collection surface only has several millimeters, is unable to satisfy whole The needs observed in terms of volume morphing.If collection surface equally only has several millimeters using spectrometer collection mode.High-spectrum As technology can satisfy the needs of large area analysis, but it is the basis signal of quantitative analysis, needs to solve unified measure and uniformly Property problem.
Summary of the invention
For the problems in background technique, it is an object of the invention to:
(1) a kind of skin hyper-spectral data gathering unit is provided, adjustable by force by multiple light courcess configuration and LED light source Single wavelength spoke, The strong balancing technique of full spectral coverage spoke, makes acquisition unit achieve the purpose that noise reduction, to improve skin EO-1 hyperion quantitative analysis system Accuracy.
(2) a kind of skin hyper-spectral data gathering unit is provided, by light path design, solution homogeneity question be (30mmx25mm's Collection surface), so that skin EO-1 hyperion quantitative analysis system is provided with morphological analysis ability.
(3) a kind of two-stage standard correction method is provided, solves the consistency problem of system, has unified metering.
To achieve the goals above, technical scheme is as follows:
A kind of skin high spectrum image acquisition unit, including power supply unit, light source assembly, EO-1 hyperion camera, be optically isolated Cover;
Described be optically isolated on cover is provided with an acquisition hole, and light source assembly and the setting of EO-1 hyperion camera are optically isolated described In cover;
It takes pictures through EO-1 hyperion camera under the irradiation of the light source assembly by acquisition hole and obtains skin in dermal harvest region Skin high spectrum image;
The power supply unit connection light source assembly is powered for it;
It is characterized by:
It further include having reference substance component;The reference substance component includes suit blank and gradient reflecting plate, and the suit is white Plate realizes correction of the skin high spectrum image to acquisition in planar dimensions, and the gradient reflecting plate realizes the skin to acquisition Correction of the high spectrum image in spectral Dimensions;
The suit blank includes two parts, and a part is square frame, is attached to inside acquisition hole, adopts at random every time Frame is also collected simultaneously when collecting object;Another part is rectangular blank, is covered on acquisition hole, acquisition target object location Panel data realizes the correction of analysis plane;
The gradient reflecting plate is 8 pieces of on-gauge plates of different reflectivity, is fitted on the outside of acquisition hole respectively, and acquisition, which measures, adopts Each point measured value in collection face, realizes the correction of spectral Dimensions.
Further, the light source assembly is configured using multiple light courcess, including tungsten light source and LED light source;The LED light Light source is LED lamp bead of one group of wave-length coverage between 395-500nm.
Further, the LED light source is arranged one at interval of 5nm wavelength, is made of 12 LED lamp beads, amounts to 4 groups It is symmetrically arranged setting.
Further, the power supply that the power supply unit is connect with the LED lamp bead of each wavelength is all made of customization power supply, this is fixed Voltage, the electric current of power supply processed are individually adjusted.
Further, the nominal reflectivity of the gradient reflecting plate be respectively 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2%.
Further, the useful region after the acquisition unit actual acquisition area removal dash area includes three parts:
1) effective blank correcting area, a part of random standard white plate are outside 100mm x 100mm, inner edge 95mm x95mm;
2) effective viewing area is 50mm x 50mm;
3) effective analyzed area is 30mm x 25mm.
A kind of scaling method for the skin high spectrum image acquisition unit, which is characterized in that the method packet Include following steps:
(1) first order corrects: according to the relativeness between rectangular blank and square frame, to each in analyzed area Point, each acquisition are carried out to mark, and normalization amendment forms level-one corrected parameter table;
(2) it second-order correction: is corrected by a set of gradient reflecting plate, to the gradient reflecting plate under every piece of different reflectivity On-gauge plate surveyed, the opening relationships between measured value and standard value forms the relevant actual covering visible light of equipment Relationship between the reflectivity detected value and variable of full spectral coverage, i.e. Second level amendment parameter list;To every equipment, every time it measures As a result amendment is normalized, unifies onto the measurement criteria of metrological service.
Further, in the step (1), when normalization is corrected, effective density 170px150p, total 25500 are repaired On schedule;In step (2), it is divided into 10nm between effective density, amounts to 31 adjusting points.
Further, the nominal reflectivity of the gradient reflecting plate be respectively 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2%.
The beneficial effect of the present invention compared with the existing technology is:
(1) by noise-reducing design, the accuracy of system is improved.Using the LED lamp bead of one group of different wave length to 395- 500nm wave-length coverage carries out light filling, and every interval 5nm takes a LED lamp bead, and one group is made of 12 LED lamp beads, uses 4 groups altogether, from And the spoke of 390-500 range of wavelengths in visible spectrum is drawn high by force;
Meanwhile customize voltage, current adjustment power supply for the LED lamp bead of each wavelength, can to each wavelength LED lamp bead voltage and Electric current is individually adjusted, and the spoke of entire visible spectrum is strong overall balanced, that is, is suitable for data processing, is in turn ensured higher noise Than.
(2) by two-stage standard correction, it ensure that the acquisition light in acquisition plane, between each acquisition and distinct device The consistency of modal data, it is unified to calibrate, solve consistency problem.
(3) it by light path design, solves acquisition hole and determines area (30mmx25mm) interior uniform illumination, have system There is morphological analysis ability.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of acquisition unit of the invention;
Fig. 2 is multiple light courcess configuration schematic diagram of the invention;
Fig. 3 is the noise reduction comparison diagram of acquisition unit of the present invention;
Fig. 4 is the second level calibration correction map of scaling method of the present invention.
In figure, 1- light source assembly, 2- EO-1 hyperion camera, 3- is optically isolated cover, and 4- acquires hole, 5- tungsten light source, 6-LED lamp Light source.
In Fig. 3, horizontal axis is represented wavelength (unit nm), and the longitudinal axis is that opposite spoke is strong (no unit);B line segment represents tungsten lamp transmitting light Spectrum, A line segment represent the combined light source emission spectrum of tungsten lamp and LED light.
In Fig. 4, horizontal axis is actual measurement reflectivity, and the longitudinal axis is standard emission rate;It is anti-that line segment 1 represents not calibrated measurement-calibration Rate relation curve is penetrated, line segment 2 represents measurement-calibration reflectivity corresponding relationship curve after calibration.
Specific embodiment
With reference to the accompanying drawings and detailed description, detailed elaboration is made to specific embodiments of the present invention.These tools Body embodiment is only not supposed to be a limitation to the present invention for narration or implementation principle, and protection scope of the present invention is still with power Subject to benefit requires, including obvious changes or variations etc. made on this basis.
As shown in Figure 1, 2, a kind of skin high spectrum image acquisition unit, including power supply unit, light source assembly 1, EO-1 hyperion Camera 2 is optically isolated cover 3;Cover is optically isolated with cavity structure, is provided with an acquisition hole 4, shape is not construed as limiting.Light Source component and EO-1 hyperion camera are mounted on described be optically isolated in cover.Power supply unit connection light source assembly is powered for it.
When practical operation, dermal harvest region is by acquisition hole, under the irradiation of the light source assembly 1, through EO-1 hyperion phase Machine, which is taken pictures, obtains skin high spectrum image.
The invention also includes have reference substance component.The reference substance component includes suit blank and gradient reflecting plate, the set It fills blank and realizes correction of the skin spectrum image to acquisition in planar dimensions, the gradient reflecting plate realizes the skin to acquisition Correction of the skin spectrum picture in spectral Dimensions.Wherein, suit blank includes two parts, and a part is square frame, at random It is attached to inside acquisition hole, frame is also collected simultaneously when acquiring object every time;Another part is rectangular blank, is covered in and adopts Collect on hole, acquire the panel data of target object location, realizes the correction of analysis plane.Gradient reflecting plate is the 8 of different reflectivity Block on-gauge plate is fitted in respectively on the outside of acquisition hole, and acquisition measures each point measured value in collection surface, realizes the school of spectral Dimensions Just.
In the present invention, the nominal reflectivity of 8 block gradient reflecting plates is respectively 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2%.Numerical value is set relative to other, which is arranged so that measurement is more accurate.
Light source assembly of the invention is configured using multiple light courcess, including tungsten light source and LED light source;Wherein LED light source For LED lamp bead of one group of wave-length coverage between 395-500nm.LED light source is arranged one at interval of 5nm wavelength, by 12 LED lamp bead composition amounts to 4 groups of symmetric arrays settings.The power supply that power supply unit is connect with the LED lamp bead of each wavelength is all made of fixed Power supply processed, voltage, the electric current of the customization power supply are individually adjusted.From figure 3, it can be seen that from 400 nanometers to 550 nanometer, light source Intensity have the signal-to-noise ratio for being obviously improved, improving significantly.
Useful region in the present invention after acquisition unit actual acquisition area removal dash area includes three parts:
1) effective blank correcting area, a part of random standard white plate are outside 100mm x 100mm, inner edge 95mm x95mm;
2) effective viewing area is 50mm x 50mm;
3) effective analyzed area is 30mm x 25mm.
A kind of scaling method for skin high spectrum image acquisition unit of the present invention, which is characterized in that the method packet Include following steps:
(1) first order corrects: according to the relativeness between rectangular blank and frame blank, to each in analyzed area Point, each acquisition are carried out to mark, and normalization amendment forms level-one corrected parameter table;
(2) second-order correction: being corrected by a set of gradient reflecting plate, to every piece of different gradient reflectivity Gradient reflection The on-gauge plate of plate is surveyed, the opening relationships between measured value and standard value, and it is visible to form the relevant actual covering of equipment Relationship between the reflectivity detected value and variable of the full spectral coverage of light, i.e. Second level amendment parameter list;To every equipment, each measurement Result be normalized amendment, it is unified in the measurement criteria of metrological service.Wherein, in the step (1), normalization amendment When, effective density 170px150p amounts to 25500 adjusting points;In step (2), it is divided into 10nm between effective density, amounts to 31 A adjusting point.The nominal reflectivity of gradient reflecting plate is respectively 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2%.
Figure 4, it is seen that accurately calibration reflectivity can be obtained in the reflectivity of measurement after calibration.

Claims (9)

1. a kind of skin high spectrum image acquisition unit, including power supply unit, light source assembly, EO-1 hyperion camera, it is optically isolated cover;
Described be optically isolated on cover is provided with an acquisition hole, and light source assembly and EO-1 hyperion camera, which are arranged, is optically isolated cover described It is interior;
It takes pictures through EO-1 hyperion camera under the irradiation of the light source assembly by acquisition hole and obtains skin height in dermal harvest region Spectrum picture;
The power supply unit connection light source assembly is powered for it;
It is characterized by:
It further include having reference substance component;The reference substance component includes suit blank and gradient reflecting plate, and the suit blank is real The now correction to the skin high spectrum image of acquisition in planar dimensions, the gradient reflecting plate realize the skin bloom to acquisition Correction of the spectrogram picture in spectral Dimensions;
The suit blank includes two parts, and a part is square frame, is attached to inside acquisition hole at random, acquires mesh every time Frame is also collected simultaneously when marking object;Another part is rectangular blank, is covered on acquisition hole, acquires the plane of target object location Data realize the correction of analysis plane;
The gradient reflecting plate is 8 pieces of on-gauge plates of different reflectivity, is fitted on the outside of acquisition hole respectively, acquisition measures collection surface Interior each point measured value, realizes the correction of spectral Dimensions.
2. a kind of skin high spectrum image acquisition unit according to claim 1, it is characterised in that:
The light source assembly is configured using multiple light courcess, including tungsten light source and LED light source;The LED light source is one group of wave LED lamp bead of the long range between 395-500nm.
3. according to a kind of skin high spectrum image acquisition unit as claimed in claim 2, it is characterised in that: the LED light source is every It is spaced 5nm wavelength and is arranged one, be made of 12 LED lamp beads, amount to 4 groups of symmetric arrays settings.
4. a kind of skin high spectrum image acquisition unit according to claim 2, it is characterised in that:
The power supply that the power supply unit is connect with the LED lamp bead of each wavelength is all made of customization power supply, the voltage of the customization power supply, Electric current is individually adjusted.
5. a kind of skin high spectrum image acquisition unit according to claim 1, it is characterised in that: the gradient reflecting plate Nominal reflectivity be respectively 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2%.
6. a kind of skin high spectrum image acquisition unit according to claim 1, it is characterised in that:
Useful region after the acquisition unit actual acquisition area removal dash area includes three parts:
1) effective blank correcting area, a part of random standard white plate are outside 100mm x 100mm, inner edge 95mm x95mm;
2) effective viewing area is 50mm x 50mm;
3) effective analyzed area is 30mm x 25mm.
7. a kind of scaling method for skin high spectrum image acquisition unit described in claim 1, which is characterized in that described Method includes the following steps:
(1) first order corrects: according to the relativeness between rectangular blank and square frame, in analyzed area each point, Each acquisition is carried out to mark, and normalization amendment forms level-one corrected parameter table;
(2) it second-order correction: is corrected by a set of gradient reflecting plate, to the mark of the gradient reflecting plate under every piece of different reflectivity Quasi- plate is surveyed, the opening relationships between measured value and standard value, is formed the relevant actual covering visible light of equipment and is composed entirely Relationship between the reflectivity detected value and variable of section, i.e. Second level amendment parameter list;To every equipment, every time the result measured Amendment is normalized, unifies onto the measurement criteria of metrological service.
8. a kind of scaling method for skin high spectrum image acquisition unit as claimed in claim 7, it is characterised in that: described In step (1), when normalization is corrected, effective density 170px150p amounts to 25500 adjusting points;In step (2), correct close It is divided into 10nm between degree, amounts to 31 adjusting points.
9. a kind of scaling method for skin high spectrum image acquisition unit as claimed in claim 7, it is characterised in that:
The nominal reflectivity of the gradient reflecting plate is respectively 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2%.
CN201710407363.0A 2017-06-02 2017-06-02 A kind of skin high spectrum image acquisition unit and scaling method Active CN107402070B (en)

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CN108451501A (en) * 2018-02-01 2018-08-28 福建师范大学 A kind of nevus flammeus color and area appraisal procedure based on pixel analysis
CN112417934B (en) * 2019-08-23 2024-05-14 华为技术有限公司 Image detection method and related equipment
CN116019425B (en) * 2023-03-27 2023-05-23 皑高森德医疗器械(北京)有限责任公司 Digital skin model based on hyperspectral image and application thereof
CN116012484A (en) * 2023-03-27 2023-04-25 皑高森德医疗器械(北京)有限责任公司 Skin white spot basin-shaped presentation method based on volume content of melanin
CN116012379B (en) * 2023-03-27 2023-09-08 皑高森德医疗器械(北京)有限责任公司 White spot grading method based on melanin volume content distribution form
CN117405605B (en) * 2023-12-15 2024-03-05 浙江大学 Correction system and method for eliminating non-uniform light field distribution in hyperspectral image acquisition

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