CN107397612B - Preparation method of intervertebral spinal implant - Google Patents
Preparation method of intervertebral spinal implant Download PDFInfo
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- CN107397612B CN107397612B CN201610332408.8A CN201610332408A CN107397612B CN 107397612 B CN107397612 B CN 107397612B CN 201610332408 A CN201610332408 A CN 201610332408A CN 107397612 B CN107397612 B CN 107397612B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
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Abstract
A process for preparing the vertebral column implant between vertebrae includes such steps as immersing the first and second structural bodies in the liquid low-smelting-point substance, solidifying, putting them in injection mould, injecting thermoplastic polymer between them by high-speed injection moulding machine, taking out the resultant composite, and heating to remove the low-smelting-point substance from them.
Description
Technical Field
The invention relates to a method for preparing a prosthesis capable of being transplanted into a body, in particular to a method for preparing an interbody spinal implant.
Background
The consequences of spinal tumors, spinal infectious diseases and unstable vertebral body fractures often cause serious vertebral body damage, which may further cause spinal instability and spinal cord and nerve root injuries, and even cause paralysis of patients. Such patients are increasing year by year, especially as the population ages. The anterior decompression vertebral body total or secondary total resection is considered as the main clinical surgical treatment means for spinal tumor, spinal infectious diseases and unstable vertebral body fracture. During the operation, a surgeon must reconstruct the spine with lost complete stability, and bone grafting materials are applied in the spine operation to promote bone fusion and enhance the stability of the spine. Although the autologous bone grafting is the gold standard for spinal fusion, the autologous bone grafting has the defects of limited number, prolonged operation time for bone extraction, increased complications of bone extraction area, insufficient immediate stability after operation and the like. Titanium cages and artificial vertebral body spinal implants are increasingly becoming clinically used as an effective vertebral body substitute. However, the currently used titanium cage or artificial vertebral body spinal column implant is usually a pure mechanical support material, and compared with autologous bone, the titanium cage or artificial vertebral body spinal column implant has no bone conduction, bone induction and osteogenesis functions, and can not promote the fusion of adjacent spinal column segments on the premise of restoring the stability of the spinal column; researchers have proposed using porous materials to make vertebral body spinal implants, such as CN 102612351 a which describes a composite implant for use between vertebral bodies to facilitate fusion of adjacent vertebrae, the implant including a first structural body made of a porous metal material and a second structural body made of a porous metal material, the first and second structural bodies being configured to allow bony ingrowth. The implant further includes a polymeric body positioned between and bonded to the first and second bodies such that polymeric material of the polymeric body infiltrates the apertures of the first and second endplates to bond the members together, and a cavity extending through the composite implant configured to receive bone growth material to facilitate fusion between the adjacent two vertebrae. The preparation method comprises the following steps: positioning a first surface of a polymeric body of polymeric material adjacent to a surface of a first body of porous metallic material, heating the first body of porous metallic material to a first elevated temperature, applying a compressive force between the polymeric body of polymeric material and the first body of porous metallic material such that a portion of the polymeric material enters the pores of the first body of porous metallic material, positioning a second surface of the polymeric body of polymeric material adjacent to a surface of a second body of porous metallic material, heating the second body of porous metallic material to a second elevated temperature, and applying a compressive force between the polymeric body of polymeric material and the second body of porous metallic material, thereby causing a portion of the polymer material to enter the pores of the second structural body made of the porous metal material.
The main problem of the preparation method of the vertebral body spinal implant is that the connection between the polymer material and the porous metal material is not firm enough.
The invention content is as follows:
the invention aims to provide a preparation method of an interbody spinal implant with firm connection of polymer materials and porous materials.
The inventor thinks that the existing method is to press the porous material into the polymer due to the irregularity of the porous material, so that the polymer is difficult to completely fuse with the porous metal material, the thickness of the porous metal material is uneven, the porous metal material is not firmly connected, and a new connecting method is needed, therefore, the inventor proposes the following technical proposal:
a method of preparing an interbody spinal implant comprised of a first structure made of a porous metal material, a second structure made of a porous metal material, and a polymer structure made of a thermoplastic polymer material positioned between the first and second structures; wherein a first tie layer between the first structure and the polymeric structure comprises polymeric material infiltrated into pores of the first structure and a second tie layer between the second structure and the polymeric structure comprises polymeric material infiltrated into pores of the second structure; and a cavity extending through the interbody spinal implant, the method comprising the steps of:
(a) immersing a first structure body made of a porous metal material into a low-melting-point substance which has a melting point lower than that of the polymer and is in a liquid state, wherein the immersion surface is the other surface opposite to the joint surface of the polymer structure body, and the immersion depth is the sum of the total height of the first structure body made of the porous metal material minus the thickness of the first joint layer, so that the low-melting-point substance in the liquid state is solidified;
(b) immersing a second structural body made of a porous metal material into the liquid low-melting-point substance in the step (a), wherein the immersion surface is the surface opposite to the joint surface of the polymer structural body, and the immersion depth is the sum of the total height of the second structural body made of the porous metal material minus the thickness of the second joint layer, so that the liquid low-melting-point substance is solidified;
(c) placing a first structural body made of the porous metal material and a second structural body made of the porous metal material, which are prepared in the steps (a) and (b), into an injection mold, wherein the surface of each structural body combined with the polymer is opposite to the surface of the other structural body combined with the polymer, the other surface of each structural body opposite to the surface combined with the polymer is fixed, the distance between the surfaces combined with the polymer of the two structural bodies is the height of the part of the polymer structural body not combined with the first structural body and the second structural body, and an injection port is arranged between the surfaces combined with the polymer of the two structural bodies; the high-speed injection molding machine fills the cavity between the two structural bodies with the molten polymer raw material through an injection port within 4 seconds after the first structural body and the second structural body are placed in an injection mold, the mold is cooled, the injection mold is opened, and the first structural body made of the porous metal material, the second structural body made of the porous metal material and the compound formed by the polymer are taken out;
(d) heating the compound in the step (c) to the melting point of the low-melting-point substance in the step (a) to separate the low-melting-point substance from the first structural body made of the porous metal material and the second structural body made of the porous metal material, then cleaning the porous metal material, and then carrying out subsequent machining to obtain the interbody spinal implant.
Furthermore, the melting point of the low-melting-point substance is more than 70 ℃ lower than the melting point of the polymer, so that the polymer structure body can be prevented from being damaged when the low-melting-point substance is removed.
Furthermore, in the preparation method of the intervertebral vertebral body spinal implant, the polymer is polyether ether ketone (PEEK) or ultra-high molecular weight polyethylene (UHMWPE) or polymethyl methacrylate (PMMA).
Furthermore, in the preparation method of the intervertebral vertebral column implant, the low-melting-point substance is paraffin, chitosan, polylactic acid or polyglycolic acid.
Furthermore, the preparation method of the vertebral body spine implant is characterized in that before injection molding, the first structural body made of the porous metal material and the part of the second structural body made of the porous metal material, which is combined with the polymer, are subjected to roughening treatment, so that the first structural body, the second structural body and the polymer structural body are combined more firmly.
Furthermore, the roughening treatment method of the preparation method of the vertebral interbody spinal implant is sand blasting, acid washing or micro-arc oxidation.
Furthermore, in the preparation method of the intervertebral vertebral body spine implant, the porous metal material is prepared from medical titanium and alloy, medical niobium and alloy, medical tantalum and alloy, medical stainless steel, medical cobalt-based alloy or medical magnesium and alloy.
The invention has the beneficial effects that:
(1) the invention provides a preparation method of a vertebral body spine implant, which comprises the steps of immersing a polymer in a molten state into a porous metal material through injection molding to form a first structural body and a first bonding layer of the polymer and a second structural body and a second bonding layer of the polymer, and molding the polymer structural body.
(2) The polymer structure can be advantageously protected by lowering the melting point of the low-melting substance to 70 ℃ or higher than the melting point of the polymer.
(3) Before injection molding, the first structural body made of the porous metal material and the second structural body made of the porous metal material are subjected to roughening treatment, so that the first structural body, the second structural body and the polymer structural body are combined more firmly after injection molding.
Drawings
The invention will be further elucidated with reference to the embodiments and drawings.
FIG. 1 is a schematic view of an interbody spinal implant of the present invention.
Fig. 2 is a top view of fig. 1.
Fig. 3 is a schematic view showing a first structure body made of a porous metal material immersed in a liquid low-melting substance.
Fig. 4 is a schematic view of a first structure body made of a porous metal material and a second structure body made of a porous metal material in an injection mold.
Detailed Description
The following description will be made in conjunction with the accompanying drawings, which are provided to explain the embodiments of the present invention in detail and to explain the detailed embodiments and the specific operation procedures based on the technical solutions of the present invention, but the scope of the present invention is not limited to the following embodiments.
As shown in fig. 1 and 2, 1 is a first structural body, 2 is a second structural body, 3 is a polymer structural body, 4 is a cavity, 5 is a first junction layer, 6 is a second junction layer, H is the total height of the interbody spinal implant, T1 and T2 are the heights of the first structural body 1 and the second structural body 2, respectively, T4 and T5 are the thicknesses of the first junction layer 5 and the second junction layer 6, respectively, and T3 is the height of the portion of the polymer structural body 3 that is not bonded to the first structural body 1 and the second structural body 2. In FIG. 3, 7 denotes a container, and 8 denotes a low melting point substance in a liquid state. In fig. 4, 9 is the left mold of the injection mold, 10 is the right mold of the injection mold, and 11 is the injection port.
Example 1
An interbody spinal implant, consisting of a first body 1 made of porous titanium, a second body 2 made of porous titanium and a polymeric body 3 made of a thermoplastic polymeric material Polyetheretherketone (PEEK), said polymeric body 3 being positioned between the first body 1 and the second body 2; wherein a first tie layer 5 between the first body 1 and the polymeric body 3 comprises a polymeric material infiltrated into the pores of the first body 1, and a second tie layer 6 between the second body 2 and the polymeric body 3 comprises a polymeric material infiltrated into the pores of the second body; and a cavity 4 penetrating the interbody spinal implant, the porous titanium adopted by the first structure and the second structure being prepared by a foam impregnation method, the pore size of the porous titanium being 350 [ mu ] m to 550 [ mu ] m, the thickness T4 of the first bonding layer 5 and the thickness T6 of the second bonding layer 6 being 1.8mm, the height T1 of the first structure 1 and the height T2 of the second structure 2 being 3.8mm, respectively, the height T3 of the portion of the polymer structure 3 not bonded to the first structure 1 and the second structure 2 being 5.4mm, and the total height H of the interbody spinal implant being 13 mm. The preparation method comprises the following steps:
(a) the first structural body 1 made of porous titanium is subjected to roughening treatment by adopting a micro-arc oxidation process, and the formula of the used electrolyte is as follows: EDTA-2Na content 15g/L, Ca (CH)3COO)2·H2O content of 8.8g/L, Na2SiO3·9H2The O content was 14.2g/L, the NaOH content was 20g/L, the voltage was 400V, the frequency was 600Hz, the duty ratio was 8%, and the oxidation time was 5min, and then the first structure 1 was immersed in the low melting point substance 8 (polyglycolic acid as the low melting point substance in this example) in a liquid state in the vessel 7, and the immersion surface was a structure of a polymer3 to a depth of T4, i.e., T1-T4=3.8mm-1.8mm =2mm, which is the total height T1 of the first structure 1 made of porous titanium minus the thickness of the first joining layer, and cooling the structure to solidify polyglycolic acid in a liquid state;
(b) similarly, the second structure body 2 made of porous titanium is also subjected to the micro-arc oxidation treatment described in (a), and then immersed in polyglycolic acid in a liquid state in the container 7 described in (a) with the immersion surface being the surface opposite to the bonding surface of the polymer structure to a depth of T5, i.e., T2 to T5=3.8mm-1.8mm =2mm, which is the total height T2 of the second structure body 2 made of porous titanium minus the thickness T of the second bonding layer, and cooled to solidify the polyglycolic acid in a liquid state;
(c) placing a first structure body 1 made of porous titanium and prepared in the steps (a) and (b) and a second structure body 2 made of porous titanium into an injection mold, wherein the first structure body 1 is fixed at the inner end part of a left mold 9, the part of the first structure body 1 immersed in polyglycolic acid is close to the inner end part of the left mold 9, the second structure body 2 is fixed at the inner end part of a right mold 10, the part of the second structure body 2 immersed in polyglycolic acid is close to the inner end part of the right mold 9, the surface of each structure body combined with a polymer is opposite to the surface of the other structure body combined with the polymer, the distance between the surfaces of the two structure bodies combined with the polymer is 5.4mm of the height T3 of the part of the polymer structure body 3 not combined with the first structure body 1 and the second structure body 2, and an; and (3) filling a cavity between the two structural bodies with molten polyether ether ketone (PEEK) through an injection port 11 by a high-speed injection molding machine within 4 seconds after the first structural body and the second structural body are placed in an injection mold, carrying out injection molding under the pressure of 152MPa at the injection speed of 94 cm/s, cooling the mold with water, opening the injection mold, and taking out a compound formed by the first structural body, the second structural body and the polymer.
(d) And (c) heating the compound in the step (c) to the melting point of the polyglycolic acid of 225 ℃, separating the polyglycolic acid from the first structure body 1 and the second structure body 2, cleaning the first structure body 1 and the second structure body 2, removing a dead head, processing a cavity 4, and the like, and then performing subsequent machining to obtain the intervertebral spinal implant.
In this example, the melting points of the polymer Polyetheretherketone (PEEK) and the low melting substance polyglycolic acid differ by 118 ℃.
The composite implant prepared by the invention has the advantages that the polymer structure body is tightly jointed with the first structure body and the second structure body, the thickness of the first jointing layer and the second jointing layer is uniform, the reliability of the composite implant is improved, the service life of the composite implant is prolonged, and the grown bone tissues are uniform.
Example 2
The interbody spinal implant of the present embodiment is composed of a first structural body 1 made of porous niobium, a second structural body 2 made of porous niobium, and a polymeric structural body 3 made of a thermoplastic polymeric material Polymethylmethacrylate (PMMA), the polymeric structural body 3 being positioned between the first structural body 1 and the second structural body 2; wherein a first tie layer 5 between the first body 1 and the polymeric body 3 comprises a polymeric material infiltrated into the pores of the first body 1, and a second tie layer 6 between the second body 2 and the polymeric body 3 comprises a polymeric material infiltrated into the pores of the second body; and a cavity 4 penetrating the interbody spinal implant, the porous niobium used for the first structure and the second structure being prepared by a foam impregnation method, the pore size of the porous niobium being 300 [ mu ] m to 500 [ mu ] m, the thickness T4 of the first bonding layer 5 and the thickness T6 of the second bonding layer 6 being 1.6mm, the height T1 of the first structure 1 and the height T2 of the second structure 2 being 4.1mm, respectively, the height T3 of the portion of the polymer structure 3 not bonded to the first structure 1 and the second structure 2 being 5.8mm, and the total height H of the interbody spinal implant being 14 mm. The preparation method is similar to that of example 1, except that the roughening treatment process is pickling: the method is carried out by adopting mixed acid solution with the concentration of 35 percent of analytically pure nitric acid and 15 percent of analytically pure hydrofluoric acid; the low-melting-point substance is paraffin, and the melting point of the polymer material polymethyl methacrylate (PMMA) is different from that of the low-melting-point substance paraffin by 87 ℃.
Example 3
The interbody spinal implant of this embodiment is comprised of a first body 1 made of porous tantalum, a second body 2 made of porous tantalum, and a polymeric body 3 made of a thermoplastic polymeric material, Ultra High Molecular Weight Polyethylene (UHMWPE)The body structure 3 is positioned between the first body structure 1 and the second body structure 2; wherein a first tie layer 5 between the first body 1 and the polymeric body 3 comprises a polymeric material infiltrated into the pores of the first body 1, and a second tie layer 6 between the second body 2 and the polymeric body 3 comprises a polymeric material infiltrated into the pores of the second body; and a cavity 4 penetrating the interbody spinal implant, the porous tantalum adopted by the first structure and the second structure being prepared by a foam impregnation method, the pore size of the porous tantalum being 400 [ mu ] m to 600 [ mu ] m, the thickness T4 of the first bonding layer 5 and the thickness T6 of the second bonding layer 6 being 1.5mm, the height T1 of the first structure 1 and the height T2 of the second structure 2 being 4mm, the height T3 of the portion of the polymer structure 3 not bonded to the first structure 1 and the second structure 2 being 5mm, and the total height H of the interbody spinal implant being 13 mm. The preparation method is similar to that of example 1, except that the roughening treatment process is sand blasting: carrying out sand blasting treatment on the surfaces of the first structural body 1 and the second structural body 2 combined with the polymer, wherein the pressure of a nozzle of a sand blasting machine is 0.5MPa, and 70-90 meshes of Al is adopted2O3An abrasive; taking paraffin as a low-melting-point substance, taking 168MPa of injection pressure, taking 148cm of injection speed/s, and obtaining that the difference between the melting points of the ultra-high molecular weight polyethylene (UHMWPE) as a polymer material and the low-melting-point substance paraffin is 73 ℃.
Claims (15)
1. A method of preparing an interbody spinal implant comprised of a first structure made of a porous metal material, a second structure made of a porous metal material, and a polymer structure made of a thermoplastic polymer material positioned between the first and second structures; wherein a first tie layer between the first structure and the polymeric structure comprises polymeric material infiltrated into pores of the first structure and a second tie layer between the second structure and the polymeric structure comprises polymeric material infiltrated into pores of the second structure; and a cavity extending through the intervertebral spinal implant, wherein the method of manufacture comprises the steps of:
(a) immersing a first structure body made of a porous metal material into a low-melting-point substance which has a melting point lower than that of the polymer and is in a liquid state, wherein the immersion surface is the other surface opposite to the joint surface of the polymer structure body, and the immersion depth is the sum of the total height of the first structure body made of the porous metal material minus the thickness of the first joint layer, so that the low-melting-point substance in the liquid state is solidified;
(b) immersing a second structural body made of a porous metal material into the liquid low-melting-point substance in the step (a), wherein the immersion surface is the surface opposite to the joint surface of the polymer structural body, and the immersion depth is the sum of the total height of the second structural body made of the porous metal material minus the thickness of the second joint layer, so that the liquid low-melting-point substance is solidified;
(c) placing a first structural body made of the porous metal material and a second structural body made of the porous metal material, which are prepared in the steps (a) and (b), into an injection mold, wherein the surface of each structural body combined with the polymer is opposite to the surface of the other structural body combined with the polymer, the other surface of each structural body opposite to the surface combined with the polymer is fixed, the distance between the surfaces combined with the polymer of the two structural bodies is the height of the part of the polymer structural body not combined with the first structural body and the second structural body, and an injection port is arranged between the surfaces combined with the polymer of the two structural bodies; the high-speed injection molding machine fills the cavity between the two structural bodies with the molten polymer raw material through an injection port within 4 seconds after the first structural body and the second structural body are placed in an injection mold, the mold is cooled, the injection mold is opened, and the first structural body made of the porous metal material, the second structural body made of the porous metal material and the compound formed by the polymer are taken out;
(d) heating the compound in the step (c) to the melting point of the low-melting-point substance in the step (a) to separate the low-melting-point substance from the first structural body made of the porous metal material and the second structural body made of the porous metal material, then cleaning the porous metal material, and then carrying out subsequent machining to obtain the interbody spinal implant.
2. A method of preparing an interbody spinal implant as recited in claim 1, wherein: the melting point of the low-melting-point substance is more than 70 ℃ lower than that of the polymer.
3. The method for preparing an interbody spinal implant of claim 1 or 2, wherein: the polymer is polyether ether ketone (PEEK) or ultra-high molecular weight polyethylene (UHMWPE) or polymethyl methacrylate (PMMA).
4. The method for preparing an interbody spinal implant of claim 1 or 2, wherein: the low-melting-point substance is paraffin, chitosan, polylactic acid or polyglycolic acid.
5. The method for preparing an interbody spinal implant of claim 1 or 2, wherein: before immersing the low-melting-point substance, the first structure body made of the porous metal material and the polymer-bonded portion of the second structure body made of the porous metal material are subjected to roughening treatment.
6. A method of preparing an interbody spinal implant as recited in claim 3, wherein: before immersing the low-melting-point substance, the first structure body made of the porous metal material and the polymer-bonded portion of the second structure body made of the porous metal material are subjected to roughening treatment.
7. The method of preparing an interbody spinal implant of claim 4, wherein: before immersing the low-melting-point substance, the first structure body made of the porous metal material and the polymer-bonded portion of the second structure body made of the porous metal material are subjected to roughening treatment.
8. The method of preparing an interbody spinal implant of claim 5, wherein: the roughening treatment method is sand blasting or acid cleaning or micro-arc oxidation.
9. The method for preparing an interbody spinal implant of claim 6 or 7, wherein: the roughening treatment method is sand blasting or acid cleaning or micro-arc oxidation.
10. The method for preparing an interbody spinal implant of claim 1 or 2, wherein: the porous metal material is prepared from medical titanium and alloy, medical niobium and alloy, medical tantalum and alloy, medical stainless steel, medical cobalt and alloy, or medical magnesium and alloy.
11. A method of preparing an interbody spinal implant as recited in claim 3, wherein: the porous metal material is prepared from medical titanium and alloy, medical niobium and alloy, medical tantalum and alloy, medical stainless steel, medical cobalt and alloy, or medical magnesium and alloy.
12. The method of preparing an interbody spinal implant of claim 4, wherein: the porous metal material is prepared from medical titanium and alloy, medical niobium and alloy, medical tantalum and alloy, medical stainless steel, medical cobalt and alloy, or medical magnesium and alloy.
13. The method of preparing an interbody spinal implant of claim 5, wherein: the porous metal material is prepared from medical titanium and alloy, medical niobium and alloy, medical tantalum and alloy, medical stainless steel, medical cobalt and alloy, or medical magnesium and alloy.
14. A method of preparing an interbody spinal implant as claimed in any one of claims 6 to 8, wherein: the porous metal material is prepared from medical titanium and alloy, medical niobium and alloy, medical tantalum and alloy, medical stainless steel, medical cobalt and alloy, or medical magnesium and alloy.
15. A method of preparing an interbody spinal implant as recited in claim 9, wherein: the porous metal material is prepared from medical titanium and alloy, medical niobium and alloy, medical tantalum and alloy, medical stainless steel, medical cobalt and alloy, or medical magnesium and alloy.
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| CN201610332408.8A CN107397612B (en) | 2016-05-19 | 2016-05-19 | Preparation method of intervertebral spinal implant |
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| CN201610332408.8A CN107397612B (en) | 2016-05-19 | 2016-05-19 | Preparation method of intervertebral spinal implant |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101238166A (en) * | 2005-07-01 | 2008-08-06 | 金文申有限公司 | Process for production of porous reticulated composite materials |
| CN102612351A (en) * | 2009-09-23 | 2012-07-25 | 捷迈脊柱有限公司 | Composite implant |
| CN102821716A (en) * | 2010-02-04 | 2012-12-12 | 芬斯贝利(发展)有限责任公司 | Prosthesis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102316823B (en) * | 2009-02-11 | 2016-06-08 | 新加坡南洋理工大学 | Multi-layered surgical prosthesis |
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2016
- 2016-05-19 CN CN201610332408.8A patent/CN107397612B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101238166A (en) * | 2005-07-01 | 2008-08-06 | 金文申有限公司 | Process for production of porous reticulated composite materials |
| CN102612351A (en) * | 2009-09-23 | 2012-07-25 | 捷迈脊柱有限公司 | Composite implant |
| CN102821716A (en) * | 2010-02-04 | 2012-12-12 | 芬斯贝利(发展)有限责任公司 | Prosthesis |
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| CN107397612A (en) | 2017-11-28 |
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