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CN1073874A - Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain - Google Patents

Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain Download PDF

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Publication number
CN1073874A
CN1073874A CN93100050A CN93100050A CN1073874A CN 1073874 A CN1073874 A CN 1073874A CN 93100050 A CN93100050 A CN 93100050A CN 93100050 A CN93100050 A CN 93100050A CN 1073874 A CN1073874 A CN 1073874A
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China
Prior art keywords
blood
medicine
brain
teken
sobering
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CN93100050A
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CN1047938C (en
Inventor
阎希军
吴迺峰
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Tasly Pharmaceutical Group Co Ltd
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No254 Hospital Of Pla
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Application filed by No254 Hospital Of Pla filed Critical No254 Hospital Of Pla
Priority to CN93100050A priority Critical patent/CN1047938C/en
Publication of CN1073874A publication Critical patent/CN1073874A/en
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Abstract

The invention belongs to Chinese patent medicine.Said preparation is made up of Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera, Rhizoma Corydalis, Herba Asari.Carry, concentrate, ethanol precipitation, recovery ethanol, be condensed into cream, mixing granulation, all operations of finished product packing and make through water.Its function is the yin nourishing of enriching blood, promoting blood circulation and stopping pain, cures mainly angioneurotic headache, migraine and hypertensive dizziness, headache.Can increase carotid artery and vertebrarterial blood flow, blood vessel dilating enhancing meninges microcirculation, strengthen the contraction that the tremulous pulse bar that exsomatizes causes norepinephrine through animal experiment, the clinical experiment total effective rate is up to 95%.

Description

Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain
The invention belongs to the Chinese patent medicine that pure Chinese medicinal plant is made, it relates to the component and the manufacturing process of this patent medicine.
Angioneurotic headache is a kind of commonly encountered diseases, though the part Chinese and western drugs is arranged can be used, but effect is all not satisfactory, especially the medicine document both domestic and external to the headache due to hyperactivity of liver-YANG of treatment blood deficiency, blood stasis type still is not reported, the Western medicine of treatment headache now commonly used has cafergot, it is a kind of vasodilation, only is suitable for the cerebral artery ischemia disease.In addition, the flunarizine capsule of just producing in 88 years, its mechanism of action is optionally to suppress calcium to enter cell, shrink to reduce venous, the Chinese patent medicine of controlling headache of report has and does not just have ball at present, and it is the Chinese medicine and western medicine side of closing, its mechanism is blood circulation promoting and blood stasis dispelling, and be furnished with the analgesic of Western medicine, this medicine only is suitable for headache due to invasion of exogenous pathogens and so on, to the internal injury type headache blood deficiency and blood stasis headache due to hyperactivity of liver-YANG of traditional Chinese medical science appellation poor effect then.
The object of the present invention is to provide a kind of pure Chinese medicinal preparation, can treat the headache due to internal injury category, adapt to angioneurotic headache, migraine, reach diseases such as hypertensive dizziness, headache.
By as above design, the feature of Chinese patent medicine Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain provided by the present invention is: its flavour of a drug constituent is:
Radix Angelicae Sinensis 4~9%
Rhizoma Chuanxiong 4~9%
The Radix Paeoniae Alba 2~8%
Radix Rehmanniae Preparata 2~8%
Ramulus Uncariae Cum Uncis 10~15%
Caulis Spatholobi 10~15%
Spica Prunellae 10~15%
Semen Cassiae 10~15%
Concha Margaritifera 10~15%
Rhizoma Corydalis 4~9%
Herba Asari 0.5~2%
The optimal proportion that each flavour of a drug is formed in this programme is
Radix Angelicae Sinensis 6.75%
Rhizoma Chuanxiong 6.75%
The Radix Paeoniae Alba 5.4%
Radix Rehmanniae Preparata 5.4%
An ancient unit of weight rattan 13.5%
Caulis Spatholobi 13.5%
Spica Prunellae 13.5%
Semen Cassiae 13.5%
Concha Margaritifera 13.5%
Rhizoma Corydalis 6.75%
Herba Asari 1.34%
This programme invigorate blood circulation clearly that the manufacturing process of electuary is: give processing → water before the medical material and carry → concentrate → ethanol precipitation → recovery ethanol → be condensed into cream → mixing granulation → finished product packing.Promptly get above-mentioned each medicine in proportion, decoct with water three times, each one hour, collecting decoction concentrated an amount of, the ethanol that adds 2 times of amounts, leave standstill 24 hours precipitations, get supernatant concentration and become cream, relative density is 1.3~1.4, paste-forming rate 10%, qinghuo reagent, sucrose, dextrin are dried into graininess by mixing at 1: 3: 1 again.
This prescription Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain belongs to treatment headache due to internal injury category, and Gai Yin " the brain being the reservoir of the marrow " mainly relies on liver, kidney, essence and blood and moistens and support and the transporting and transforming function of the spleen and stomach essence of water and grain, defeated be afraid of on the QI and blood fill in brain, so headache due to internal injury and liver,spleen,kidney three are dirty closely related.If the headache due to blood deficiency and blood stasis, the ascension of deficiency of YIN liver-yang needs suitable nourshing blood and promoting blood circulation, nourishing yin and calming yang is a method.And be not report in this medicine at home.
Have concurrently to invigorate blood circulation among same 5 of this medicine is enriched blood and foster the spirit of nobility, have the YANG hyperactivity suppressing suppressing the hyperactive liver among the YIN nourishing replenishing essence concurrently, the motion in quiescence regulating yin and yang.It with when be classified as monarch drug be mainly nourish blood, invigorate blood circulation, pain relieving, Radix Rehmanniae Preparata is that nourishing YIN and supplementing blood, beneficial essence are filled out marrow, because of " the brain being the reservoir of the marrow ", marrow deficiency then brains is lost foster and had a pain, and is suitable with it.The Radix Paeoniae Alba is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, be used for positive blood deficiency and liver-yang high due to headache best, the Rhizoma Chuanxiong blood-activating and qi-promoting, go into gas in the blood system promoting the circulation of blood, wind-expelling pain-stopping medicine commonly used for having a headache due to the treatment blood stasis liver-yang, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong share the assistance monarch drug, and it act as nourshing blood and promoting blood circulation, nourish yin and calm the liver, wind-expelling pain-stopping.Ramulus Uncariae Cum Uncis, Concha Margaritifera, Spica Prunellae, Semen Cassiae are tranquillizing and allaying excitement, for benefit is controlled medicine, and the promoting the circulation of blood of enriching blood of assistant association Caulis Spatholobi, relaxing muscles and tendons and activating QI and blood in the collateral, the pain relieving of Rhizoma Corydalis blood-activating and qi-promoting, Herba Asari fragrance is walked to scurry, the expelling wind and cold pain relieving makes for assistant altogether.The total function in full side is the yin nourishing of enriching blood, promoting blood circulation and stopping pain.
This medicine also can be treated hypertensive dizziness headache except that curing mainly angioneurotic headache, migraine.
This medicine is through the pharmacology animal experiment: the 1. oral or intravenous injection to cat can increase common carotid artery, vertebrarterial blood flow; 2. can make to mouse mainline that its point of intersect of the capillary network increases, the external caliber chap, the microcirculatory effect of the meninges of enhancing is arranged; 3. taking medicine or injecting to make the stripped tremulous pulse bar of rabbit can resist the caused contraction of norepinephrine.
This medicine is through clinical trial: use 1000 examples, wherein male's 400 examples, women's 600 examples, 14~65 years old age, the course of disease 2 months~26 years, be headache or migraine, whole case history impassivity system exception signs, wherein the part patient all once obeyed medicines such as cafergot, gastrodine, somedon, its clinical observation result
Curative effect example number percentage rate
Cure 450 45%
Effective 100 10%
Produce effects 400 40%
Invalid 50 5% total effective rates 95%.
As seen this medical instrument has good, the easy making of performance, characteristics that cost is low.

Claims (3)

1, a kind ofly treat angioneurotic headache, migrainous Chinese patent medicine Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain is characterized in that its flavour of a drug constituent is
Radix Angelicae Sinensis 4~9%
Rhizoma Chuanxiong 4~9%
The Radix Paeoniae Alba 2~8%
Radix Rehmanniae Preparata 2~8%
Ramulus Uncariae Cum Uncis 10~15%
Caulis Spatholobi 10~15%
Spica Prunellae 10~15%
Semen Cassiae 10~15%
Concha Margaritifera 10~15%
Rhizoma Corydalis 4~9%
Herba Asari 0.5~2%
2,, it is characterized in that the optimal proportion of its flavour of a drug composition is according to the described Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain of claim 1
Radix Angelicae Sinensis 6.75%
Rhizoma Chuanxiong 6.75%
The Radix Paeoniae Alba 5.4%
Radix Rehmanniae Preparata 5.4%
Ramulus Uncariae Cum Uncis 13.5%
Caulis Spatholobi 13.5%
Spica Prunellae 13.5%
Semen Cassiae 13.5%
Concha Margaritifera 13.5%
Rhizoma Corydalis 6.75%
Herba Asari 1.34%.
3, a kind of manufacturing process of producing Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain is characterized by: give processing → water before the medical material and carry → concentrate → ethanol precipitation → recovery ethanol → be condensed into cream → mixing granulation → finished product packing.Promptly get above-mentioned each medicine in proportion, decoct with water three times, each one hour, collecting decoction concentrated an amount of, the ethanol that adds 2 times of amounts, leave standstill 24 hours precipitations, get supernatant concentration and become cream, relative density is 1.3~1.4, paste-forming rate 10%, qinghuo reagent, sucrose, dextrin are made granule by mixing oven dry in 1: 3: 1 again.
CN93100050A 1992-11-14 1993-01-09 Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain Expired - Lifetime CN1047938C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN93100050A CN1047938C (en) 1992-11-14 1993-01-09 Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN92112924.6 1992-11-14
CN92112924 1992-11-14
CN93100050A CN1047938C (en) 1992-11-14 1993-01-09 Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain

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CN1073874A true CN1073874A (en) 1993-07-07
CN1047938C CN1047938C (en) 2000-01-05

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007022710A1 (en) 2005-08-24 2007-03-01 Tianjin Tasly Pharmaceutical Co. Ltd. Chinese medicinal compositions for treating headache, formulations and processes for preparation thereof
CN1318020C (en) * 2004-06-25 2007-05-30 广东天之骄生命科技有限公司<Del/> Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process
CN100356938C (en) * 2005-12-29 2007-12-26 颜怀伟 Medicine and food dual purpose Chinese medicine for preventing and treating wind heat and headache and its manufacturing method
CN100411652C (en) * 2004-06-30 2008-08-20 天津天士力制药股份有限公司 Use of medicinal composition in preparing medicine for treating chronic brain blood supply deficiency
CN101244207B (en) * 2008-01-31 2011-01-19 临沂市欧克姆内分泌与糖尿病医学研究所 Traditional Chinese medicament for treating cardiovascular and cerebrovascular diseases with tongue bottom blood-letting acupuncture drug administration
CN1919273B (en) * 2005-08-24 2011-02-16 天津天士力制药股份有限公司 Chinese medicinal composition for treating headache
CN1872216B (en) * 2005-06-03 2011-07-13 天津天士力制药股份有限公司 Medication composition for treating headache, and preparation method
CN1919272B (en) * 2005-08-24 2011-08-10 天津天士力制药股份有限公司 Traditional Chinese medicine concentrated pill
CN1872218B (en) * 2005-06-03 2011-10-05 天津天士力制药股份有限公司 Effervesce agent for treating headache, and preparation method
CN1872215B (en) * 2005-06-03 2012-02-15 天津天士力制药股份有限公司 Drop pills for treating headache, and preparation method
CN101428094B (en) * 2007-11-06 2012-05-09 天津天士力制药股份有限公司 Application of pharmaceutical composition in preparation of medicine for improving cerebral microcirculation disturbance
CN101804108B (en) * 2009-09-25 2012-05-16 孙红梅 Traditional Chinese medicine composition for treating nervous headache
CN101194958B (en) * 2006-12-08 2013-03-27 天士力制药集团股份有限公司 Method for preparing decocted ointment for treating headache
CN101194961B (en) * 2006-12-08 2013-06-05 天士力制药集团股份有限公司 Aerosol for treating headache and method for preparing the same
CN101194965B (en) * 2006-12-08 2013-06-05 天士力制药集团股份有限公司 Mastication tablet for treating headache and method for preparing the same
CN101194945B (en) * 2006-12-08 2013-06-05 天士力制药集团股份有限公司 Tablet for treating headache and method for preparing the same
CN101194964B (en) * 2006-12-08 2013-08-21 天士力制药集团股份有限公司 Coated tablet for treating headache and method for preparing the same
WO2014094632A1 (en) * 2012-12-21 2014-06-26 天士力制药集团股份有限公司 Pharmaceutical composition for treating headache, and preparation method thereof

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1318020C (en) * 2004-06-25 2007-05-30 广东天之骄生命科技有限公司<Del/> Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process
CN100411652C (en) * 2004-06-30 2008-08-20 天津天士力制药股份有限公司 Use of medicinal composition in preparing medicine for treating chronic brain blood supply deficiency
CN1872216B (en) * 2005-06-03 2011-07-13 天津天士力制药股份有限公司 Medication composition for treating headache, and preparation method
CN1872215B (en) * 2005-06-03 2012-02-15 天津天士力制药股份有限公司 Drop pills for treating headache, and preparation method
CN1872218B (en) * 2005-06-03 2011-10-05 天津天士力制药股份有限公司 Effervesce agent for treating headache, and preparation method
EP1930020A4 (en) * 2005-08-24 2010-04-14 Tianjin Tasly Pharmaceutical Chinese medicinal compositions for treating headache, formulations and processes for preparation thereof
WO2007022710A1 (en) 2005-08-24 2007-03-01 Tianjin Tasly Pharmaceutical Co. Ltd. Chinese medicinal compositions for treating headache, formulations and processes for preparation thereof
CN1919273B (en) * 2005-08-24 2011-02-16 天津天士力制药股份有限公司 Chinese medicinal composition for treating headache
JP2009505991A (en) * 2005-08-24 2009-02-12 ティエンジン タスリー ファーマシューティカル カンパニー リミテッド A herbal medicine composition, a preparation for treating headache and a method for producing the same.
CN1919272B (en) * 2005-08-24 2011-08-10 天津天士力制药股份有限公司 Traditional Chinese medicine concentrated pill
EP1930020A1 (en) * 2005-08-24 2008-06-11 Tianjin Tasly Pharmaceutical Co., Ltd. Chinese medicinal compositions for treating headache, formulations and processes for preparation thereof
CN100356938C (en) * 2005-12-29 2007-12-26 颜怀伟 Medicine and food dual purpose Chinese medicine for preventing and treating wind heat and headache and its manufacturing method
CN101194945B (en) * 2006-12-08 2013-06-05 天士力制药集团股份有限公司 Tablet for treating headache and method for preparing the same
CN101194958B (en) * 2006-12-08 2013-03-27 天士力制药集团股份有限公司 Method for preparing decocted ointment for treating headache
CN101194961B (en) * 2006-12-08 2013-06-05 天士力制药集团股份有限公司 Aerosol for treating headache and method for preparing the same
CN101194965B (en) * 2006-12-08 2013-06-05 天士力制药集团股份有限公司 Mastication tablet for treating headache and method for preparing the same
CN101194964B (en) * 2006-12-08 2013-08-21 天士力制药集团股份有限公司 Coated tablet for treating headache and method for preparing the same
CN101428094B (en) * 2007-11-06 2012-05-09 天津天士力制药股份有限公司 Application of pharmaceutical composition in preparation of medicine for improving cerebral microcirculation disturbance
CN101244207B (en) * 2008-01-31 2011-01-19 临沂市欧克姆内分泌与糖尿病医学研究所 Traditional Chinese medicament for treating cardiovascular and cerebrovascular diseases with tongue bottom blood-letting acupuncture drug administration
CN101804108B (en) * 2009-09-25 2012-05-16 孙红梅 Traditional Chinese medicine composition for treating nervous headache
WO2014094632A1 (en) * 2012-12-21 2014-06-26 天士力制药集团股份有限公司 Pharmaceutical composition for treating headache, and preparation method thereof
US20150352168A1 (en) * 2012-12-21 2015-12-10 Tasly Pharmaceutical Group Co., Ltd. Pharmaceutical Composition for Treating Headache, and Preparation Method Thereof
EP2937094A4 (en) * 2012-12-21 2016-08-31 Tasly Pharmaceutical Group Co PHARMACEUTICAL COMPOSITION FOR TREATING CEPHALES AND PREPARATION METHOD THEREOF
US9795648B2 (en) * 2012-12-21 2017-10-24 Tasly Pharmaceutical Group Co., Ltd. Pharmaceutical composition for treating headache, and preparation method thereof
EA030048B1 (en) * 2012-12-21 2018-06-29 Тасли Фармасьютикал Груп Ко., Лтд. PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HEADACHE, SYNDROME OF THE TRAUMATIC DAMAGE OF THE CRANIAL NERVE, VANITY AND VARIETY, IRRITATION AND EXCESSIVITY, UNSCENDONTONE / ORIETRONICOLIETRES / ORIETRONICOLTS / ORHANIUM HEALTHCARE, IRRALATION AND EXCITATION, UNIQUE WIRELESS AND VERTISM, INFRASTRUCTURE

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