CN107375142B - A kind of preparation method of traditional Chinese medicine anti-wrinkle cosmetic cream - Google Patents

Abstract

A kind of preparation method of Chinese medicine beauty antiwrinkle cream, it is with water shield, Rhizoma Chuanxiong, pea, motherwort, Radix Salviae Miltiorrhizae, ginkgo leaf, aid from rice germ, grape pip is raw material, with water shelloeld pectin powder, polyethylene glycol 2000, benzyl alcohol, glycerol, sorbester p18, polysorbate60, purified water, albolene, atoleine, composite interstitial substance is made in Brazil wax, pass through extraction purification respectively, matrix melting, emulsion dispersion, it is filling and etc. to be made, preparation method of the present invention has energy-saving and emission-reduction, it is easy to operate, the advantages of being suitable for mass production, it is good according to Chinese medicine beauty antiwrinkle cream coating homogeneity made from this method, it is easily dispersed, without skin irritation and anaphylaxis, stability is good, storage process is not in layering deterioration, storage process pH stablizes, shelf life of products is up to 24 months, moderate product price, anti-wrinkle effect Good, effective percentage up to 91% is worth marketing application.

Description

A kind of preparation method of traditional Chinese medicine anti-wrinkle cosmetic cream

technical field

The invention relates to a preparation method of a traditional Chinese medicine anti-wrinkle cosmetic cream.

Background technique

The discovery and application of Chinese herbal medicine for beauty has a history of thousands of years in China. There are many beauty methods and various methods in traditional Chinese medicine, mainly including four methods: traditional Chinese medicine beauty, acupuncture beauty, massage beauty and fire therapy beauty. Chinese medicine cosmetology is the most important, most commonly used and most experienced part of these four methods.

With the development of society and the enhancement of people's fashion awareness, people are more pursuing beauty in daily life, and pay more attention to whether the skin is smooth and beautiful. Patent CN 102863552A discloses a preparation method and products of seaweed pectin, wherein, it is disclosed that seaweed pectin is an excellent substrate, which can inhibit bacteria and synergize, prolong drug residence time, promote skin absorption and epidermal regeneration, and keep skin moist and luster. and so on. Therefore, Ulva pectin has a wide application prospect in food, medicine, fine chemical industry and so on. At present, there have been traditional Chinese medicine beauty creams produced by combining traditional Chinese medicine and existing cosmetic preparation technologies on the market. However, due to the complex composition of traditional Chinese medicines, the traditional Chinese medicine beauty creams on the market are prone to poor coating uniformity, and the products are irritating to the skin. The stability is poor, the main components and the matrix are prone to stratification and deterioration during the storage process, the pH changes greatly during the storage process, the product shelf life is short, and the current anti-wrinkle products on the market are expensive and ineffective.

SUMMARY OF THE INVENTION

The object of the present invention is to provide a preparation method of a traditional Chinese medicine anti-wrinkle cosmetic cream with uniform coating and long shelf life.

The purpose of this invention is to realize through following technical measures:

A preparation method of traditional Chinese medicine anti-wrinkle cosmetic cream, which is characterized in that, it is made of seaweed, chuanxiong, pea, motherwort, salvia, ginkgo biloba, rice germ, grape seed as raw materials, water chestnut pectin powder, polyethylene glycol 2000, Benzyl alcohol, glycerol, Span 60, Tween 60, purified water, white petrolatum, liquid paraffin, and carnauba wax are used to prepare a composite matrix, which is obtained through the steps of extraction and purification, matrix melting, emulsification and dispersion, and filling.

A preparation method of a traditional Chinese medicine anti-wrinkle cosmetic cream, characterized in that it comprises the following steps:

1. Extraction and purification: using water chestnut, chuanxiong, pea, motherwort, salvia, ginkgo biloba, rice germ, and grape seed as raw materials, extracting, purifying, and drying to obtain extract powder, for subsequent use;

2. Matrix melting: take Ulva pectin powder, polyethylene glycol 2000, benzyl alcohol, glycerin, Span 60, Tween 60, and purified water and place them in a suitable container, heat to 60-80° C., and dissolve to obtain an aqueous phase. The matrix is for standby use; another white petrolatum, liquid paraffin, and carnauba wax are taken and placed in a suitable container, heated to 60-80 ° C, and dissolved to obtain an oil-phase matrix for later use;

3. Emulsifying and dispersing: Take the oil-phase matrix and the water-phase matrix obtained in step 2, add the water-phase matrix to the oil-phase matrix under the condition of stirring and keep the temperature at 60-80°C, and stir while adding. Continue stirring for 10 to 20 minutes and stop the heat preservation, put it into ice water and cool it to 40 to 45 ° C and take it out, keep the temperature at 40 to 45 ° C and keep stirring, add the extract powder obtained in step 1, while the Add edge stirring to make the extract powder evenly distributed, then add pH adjuster to adjust pH to 5.0-7.0, continue stirring and vacuum degassing until natural cooling, for use;

4. Filling: fill according to suitable packaging specifications.

Further, a method for preparing a traditional Chinese medicine anti-wrinkle cosmetic cream, characterized in that the raw materials in step 1 are 20-30 parts of water chestnut, 8-12 parts of chuanxiong, 5-9 parts of peas, and 8-12 parts of motherwort in a weight ratio. , 6-10 parts of Salvia miltiorrhiza, 6-10 parts of Ginkgo biloba, 5-9 parts of rice germ, 9-13 parts of grape seed; the extraction is to take the prescription amount of water chestnut, chuanxiong, pea, motherwort, salvia, ginkgo leaf, rice The germ and grape seeds are mixed and crushed through a 60-mesh sieve, the powder is collected, placed in a microwave extractor, and 50% to 70% of the total mass of the mixed powder is added to 10 times the volume of the mixed powder for microwave extraction. The microwave power is set to 80KW to 100KW , the microwave extraction time is 30 to 60 minutes, after the extraction is completed, filter and collect the filtrate for use.

Further, a method for preparing a traditional Chinese medicine anti-wrinkle cosmetic cream is characterized in that, the purification step in step 1 is that the collected filtrate is subjected to ultrafiltration treatment with a polystyrene plastic film with a molecular weight cut-off of 25,000 to 35,000, and the operating pressure is 0.3～ 0.5MPa, the ultrafiltration temperature is 45-50℃, and the ultrafiltrate is obtained.

Further, a preparation method of a traditional Chinese medicine anti-wrinkle cosmetic cream is characterized in that, the drying step described in step 1 is to place the collected ultrafiltrate in a spray dryer for spray drying, and set an air inlet temperature of 190°C to 210°C , the outlet air temperature is 60 ℃ ~ 80 ℃, the pump frequency is 10HZ ~ 16HZ, the drying is completed, and the extract powder is collected.

Further, a preparation method of a traditional Chinese medicine anti-wrinkle cosmetic cream is characterized in that, the water-phase matrix in step 2 comprises the following adjuvants in the weight proportions: 6-10 parts of seaweed pectin powder, 20001-6 parts of polyethylene glycol , 0.3-0.8 parts of benzyl alcohol, 0.5-1.2 parts of glycerin, 600.5-0.9 parts of Span, 601.2-1.8 parts of Tween, 12-18 parts of purified water; the oil phase matrix described in step 2 includes the following auxiliary materials by weight ratio Composition: 2-9 parts of white petrolatum, 3-7 parts of liquid paraffin, and 8-13 parts of carnauba wax.

Further, a method for preparing a traditional Chinese medicine anti-wrinkle cosmetic cream, characterized in that the stirring speed in step 3 is 60-90 r/min, the vacuum degree of the vacuum degassing is 0.05-0.08 MPa, and the pH adjusting agent It is a sodium hydroxide solution of 0.1 mol/L to 0.5 mol/L, and the temperature of the water-phase matrix and the oil-phase matrix must be the same during the process of adding the water-phase matrix to the oil-phase matrix.

The present invention has the following beneficial effects:

A preparation method of a traditional Chinese medicine anti-wrinkle cosmetic cream has the advantages of energy saving and emission reduction, simple operation and suitable for large-scale production. , Good stability, no stratification and deterioration during storage, stable pH during storage, product shelf life of up to 24 months, moderate product price, good anti-wrinkle effect, and an effective rate of up to 91%, worthy of market promotion and application.

Detailed ways

The present invention will be specifically described below through the examples. It is necessary to point out that the following examples are only used to further illustrate the present invention, and should not be construed as limiting the protection scope of the present invention, without departing from the spirit and essence of the present invention. Hereinafter, any modifications or substitutions made to the methods, steps or conditions of the present invention fall within the scope of the present invention.

Example 1

A kind of preparation of traditional Chinese medicine anti-wrinkle cosmetic cream is prepared according to the following steps:

1. Extraction and purification: Take 20 parts of water chestnut, 8 parts of Chuanxiong, 5 parts of peas, 8 parts of Motherwort, 6 parts of Salvia miltiorrhiza, 6 parts of Ginkgo biloba, 5 parts of rice germ, and 9 parts of grape seeds by weight, and place them in a universal pulverizer. The powder was mixed and crushed through a 60 mesh sieve, and the powder was collected; the above powder was placed in a microwave extractor, and 670 parts of ethanol with a volume fraction of 50% was added for microwave extraction. The microwave power was 80KW, and the microwave extraction time was 50 minutes. After the extraction is completed , filter, collect the filtrate, then the filtrate is subjected to ultrafiltration with a polystyrene plastic membrane with a molecular weight cut-off of 25,000 to 35,000, the operating pressure is 0.5MPa, and the ultrafiltration temperature is 45°C to obtain an ultrafiltrate, and the ultrafiltrate is spray-dried Spray drying is carried out in the machine, the inlet air temperature is set to 190°C, the outlet air temperature is 60°C, and the frequency of the Mono pump is 12HZ. After the drying is completed, the extract powder is collected.

2. Matrix melting: Take 6 parts of seaweed pectin powder, 20001 parts of polyethylene glycol, 0.3 part of benzyl alcohol, 0.5 part of glycerin, 600.5 parts of Span, 601.2 parts of Tween, and 18 parts of purified water, and put them in a stainless steel stirring tank. Heating to 80°C, dissolving to obtain an aqueous matrix for subsequent use; separately taking 2 parts of white vaseline, 3 parts of liquid paraffin, and 8 parts of carnauba wax and placing them in a stainless steel stirring tank, heating to 80°C, and dissolving to obtain an oil phase matrix for subsequent use;

3. Emulsifying and dispersing: Take the oil-phase matrix and the water-phase matrix obtained in step 2, add the water-phase matrix to the oil-phase matrix under the condition of stirring and keep the temperature at 80°C, set the rotating speed to 60r/min, and stir while adding, After adding, continue stirring for 10 minutes and stop heat preservation, put it into ice water and cool it to 40 ° C and take out, keep the temperature at 40 ° C and keep stirring, add the extract powder obtained in step 1, add edges Stir to make the extract powder evenly distributed, then add 0.1mol/L sodium hydroxide solution to adjust pH to 5.0, continue stirring and vacuum degassing, vacuum degree is 0.05MPa, until natural cooling, standby;

4. Filling: fill according to suitable packaging specifications.

Test 1: skin allergy and irritation test

Experimental Materials:

1. Test group: Chinese medicine anti-wrinkle cosmetic cream in the present embodiment 1;

2. Matrix control group: blank matrix without traditional Chinese medicine components prepared by the preparation method of Example 1;

OBJECTIVE: To observe whether the local skin administration of traditional Chinese medicine anti-wrinkle cosmetic cream has immunogenicity (allergy) and local irritation, evaluate the safety of traditional Chinese medicine anti-wrinkle cosmetic cream, and provide a basis for clinical medication.

Method: 1.BT test:

The 40 guinea pigs were divided into 4 groups, namely the test group, the matrix control group, the negative control group and the positive control group, with 10 animals in each group. Animals in each group were sensitized on day 1, day 7, and day 14, and challenged on day 14 after the last sensitization. Immediately after drug removal, the application site response was then visually observed and recorded at 24, 48, and 72 hours post-dose.

2. Repeated administration skin irritation test:

The 16 Japanese white rabbits that passed the quarantine were randomly divided into 2 groups according to their gender and weight, with 8 rabbits in each group, half male and half male, and used for irritation test on intact skin and damaged skin respectively. Using the self-contrast method on the left and right sides of the same body, the left side of the experimental animal was coated with the test substance, and the right side was coated with the test substance matrix (blank matrix without traditional Chinese medicine extract powder) or 0.9% sodium chloride injection as the control. Then 8 Japanese white rabbits in the intact skin group and the damaged skin group were randomly divided into 2 groups according to body weight and sex, namely: the test group and the matrix control group. 4 in each group, half male and half female. Each group was given the corresponding test article, once a day, each time lasted 4 hours for 14 consecutive days. Visual observation of the administration site was performed 1 hour after each drug removal and before re-administration, and the irritation response and its occurrence and disappearance time were recorded. 60-120 minutes, 24, 48 and 72 hours after the removal of the last drug administration, the irritant response of the application site was observed and recorded with the naked eye.

Results: 1.BT test:

During the sensitization period, no abnormal reaction was found in each group of animals after administration. The animals in the test group 1, the matrix control group and the negative control group had no allergic reaction symptoms on the skin after the challenge, and the allergic reaction rate was 0. The positive control group had obvious allergic reactions on the skin after the challenge, and the allergic reaction rate was 90%. .

2. Repeated administration skin irritation test:

During the administration period and after administration of the animals in the intact skin group, there was no obvious irritation phenomenon such as erythema and edema in the appearance of the administration site with the naked eye, and the average skin irritation response score of each group was 0. In the damaged skin group, mild erythema and crusting were observed in the early stage of administration (1 to 4 days), and there was no significant difference between the groups. In the mid-administration period, the erythema gradually disappeared, and the time and degree of skin healing were basically the same.

Conclusion Under the conditions of this test, the BT test results of traditional Chinese medicine anti-wrinkle cosmetic cream were negative. In the skin irritation test of repeated administration, no obvious irritation was found to the normal and damaged skin of Japanese white rabbits.

Therefore, the traditional Chinese medicine anti-wrinkle cosmetic cream prepared in Example 1 has no skin irritation and skin allergy. Test 2: Stability and Coating Uniformity Test

Test method: The finished cosmetic cream sample of Example 1 was packaged in the market, placed in a long-term sample box, sampled for a certain period of time, and the inspection items were inspected.

Temperature: 30±2℃

Humidity: RH65%±5%

Inspection time: March, June, September, December, 18, 24

Investigation indicators: traits and coating uniformity, Ginkgo biloba thin layer identification, motherwort thin layer identification, tanshinone content, pH and microbial limit inspection.

Continued table:

The test results of stability and coating uniformity show that the quality of this product within 24 months is comparable to that of 0 month, so the quality of this product is stable, so the shelf life of this product is at least 24 months.

Experiment 3: Clinical Experiment

50 patients with wrinkles on their faces were selected as treatment objects, and the Chinese medicine anti-wrinkle cosmetic cream of the present invention was used for treatment. After three months of use, the effective rate of the treatment group was 91%. It can be seen that the treatment of the Chinese medicine anti-wrinkle cosmetic cream of the present invention The effect is outstanding.

Clinical example

Liu, female, 23, a student, due to internal and external reasons, many small wrinkles appeared on her forehead, her skin was relatively loose, and multiple treatments were ineffective. After using the traditional Chinese medicine anti-wrinkle cosmetic cream of the present invention for three months, the forehead wrinkles were greatly improved , the skin is smooth and white.

Huang, female, 30, a company employee, due to internal and external reasons, many small wrinkles appeared at the corners of her eyes, her skin was rough, and multiple treatments were ineffective. After using the traditional Chinese medicine anti-wrinkle beauty cream of the present invention for three months, the wrinkles at the corners of her eyes gradually decreased, and the skin became delicate bouncy.

Wang, female, 36, self-employed, due to internal and external reasons, many small wrinkles appeared in the corners of the eyes and forehead, the skin was rough, lacking luster, and the multi-treatment treatment was ineffective. Gradually reduce, the skin becomes smooth, delicate and elastic.

Example 2

A kind of preparation of traditional Chinese medicine anti-wrinkle cosmetic cream is prepared according to the following steps:

1. Extraction and purification: Take 30 parts of water chestnut, 12 parts of Chuanxiong, 9 parts of peas, 12 parts of Motherwort, 10 parts of Salvia miltiorrhiza, 10 parts of Ginkgo biloba, 9 parts of rice germ, and 13 parts of grape seeds by weight, and place them in a universal pulverizer. The powder was mixed and crushed through a 60 mesh sieve, and the powder was collected; the above powder was placed in a microwave extractor, and 1050 parts of ethanol with a volume fraction of 70% were added for microwave extraction. The microwave power was 100KW, and the microwave extraction time was 60 minutes. After the extraction is completed , filter, collect the filtrate, then the filtrate is subjected to ultrafiltration treatment with a polystyrene plastic film with a molecular weight cut-off of 25,000 to 35,000, the operating pressure is 0.3MPa, and the ultrafiltration temperature is 50 °C to obtain an ultrafiltrate, and the ultrafiltrate is spray-dried Spray drying in the machine, set the inlet air temperature to 210°C, the outlet air temperature to 80°C, and the Mono pump frequency to 10HZ. After the drying is completed, the extract powder is collected.

2. Matrix melting: Take 10 parts of seaweed pectin powder, 20006 parts of polyethylene glycol, 0.8 parts of benzyl alcohol, 1.2 parts of glycerol, 600.9 parts of Span, 601.8 parts of Tween, and 13 parts of purified water, and put them in a stainless steel stirring tank. Heating to 80°C, dissolving to obtain a water-phase matrix for subsequent use; separately taking 9 parts of white vaseline, 7 parts of liquid paraffin, and 13 parts of carnauba wax and placing them in a stainless steel stirring tank, heating to 80°C, and dissolving to obtain an oil-phase matrix for subsequent use;

3. Emulsifying and dispersing: Take the oil-phase matrix and the water-phase matrix obtained in step 2, add the water-phase matrix to the oil-phase matrix under the condition of stirring and keep the temperature at 80 °C, set the rotating speed to 90r/min, and stir while adding. After completion, continue to stir for 10 minutes and stop heat preservation, put it into ice water and cool down to 45 ° C and take out, keep the temperature at 45 ° C and continue to stir, add the extract powder obtained in step 1, and stir while adding , make the extract powder evenly distributed, then add 0.5mol/L sodium hydroxide solution to adjust the pH to 7.0, continue stirring and vacuum degassing, the vacuum degree is 0.08MPa until natural cooling, standby;

4. Filling: fill according to suitable packaging specifications.

Take the product obtained in Example 2 and carry out the skin allergy, irritation test, stability, coating uniformity test, and clinical test respectively according to the experimental method of Example 1. The experimental results show that the anti-wrinkle cream prepared in Example 2 has no effect. Skin allergy and irritation, stability, coating uniformity test results show that this product has good stability, uniform coating, no particle touch, shelf life of up to 24 months, clinical test results show that this product has excellent anti-wrinkle treatment effect.

Example 3

A kind of preparation of traditional Chinese medicine anti-wrinkle cosmetic cream is prepared according to the following steps:

1. Extraction and purification: Take 25 parts of water chestnut, 10 parts of Chuanxiong, 7 parts of peas, 11 parts of motherwort, 9 parts of Salvia miltiorrhiza, 8 parts of ginkgo biloba, 7 parts of rice germ, and 11 parts of grape seeds by weight, and place them in a universal pulverizer. The powder was mixed and crushed through a 60-mesh sieve, and the powder was collected; the powder was placed in a microwave extractor, and 880 parts of ethanol with a volume fraction of 60% were added for microwave extraction. The microwave power was 90KW, and the microwave extraction time was 40 minutes. After the extraction was completed , filter, collect the filtrate, then the filtrate is subjected to ultrafiltration with a polystyrene plastic film with a molecular weight cut-off of 25,000 to 35,000, the operating pressure is 0.4MPa, and the ultrafiltration temperature is 48°C to obtain an ultrafiltrate, and the ultrafiltrate is spray-dried Spray drying is carried out in the machine, the inlet air temperature is set to 200°C, the outlet air temperature is 70°C, and the frequency of the Mono pump is 13HZ. After the drying is completed, the extract powder is collected.

2. Matrix melting: Take 8 parts of water chestnut pectin powder, 3 parts of polyethylene glycol 2000, 0.6 part of benzyl alcohol, 0.9 part of glycerin, 0.8 part of Span 60, 1.5 parts of Tween 60, and 16 parts of purified water, and place them in stainless steel and stir. In the tank, heated to 70 ℃, after dissolving, the water phase matrix was obtained for subsequent use; in addition, 6 parts of white vaseline, 5 parts of liquid paraffin, and 10 parts of carnauba wax were placed in a stainless steel stirring tank, heated to 70 ℃, and dissolved to obtain an oil phase. Substrate spare;

3. Emulsifying and dispersing: Take the oil-phase matrix and the water-phase matrix obtained in step 2, add the water-phase matrix to the oil-phase matrix under the condition of stirring and keeping the temperature at 70 °C, set the rotation speed to 80r/min and stir while adding. After completion, continue stirring for 13 minutes and stop the heat preservation, put it into ice water and cool down to 43 ° C and take out, keep the temperature at 43 ° C and continue to stir, add the extract powder obtained in step 1, and stir while adding , make the extract powder evenly distributed, then add 0.3mol/L sodium hydroxide solution to adjust pH to 6.0, continue stirring and vacuum degassing treatment, vacuum degree is 0.06MPa until natural cooling, standby;

4. Filling: fill according to suitable packaging specifications.

Take the product obtained in Example 3 and carry out the skin allergy, irritation test, stability, coating uniformity test, and clinical test respectively according to the experimental method of Example 1. The experimental results show that the anti-wrinkle cream prepared in Example 2 has no effect. Skin allergy and irritation, stability, coating uniformity test results show that this product has good stability, uniform coating, no particle touch, shelf life of up to 24 months, clinical test results show that this product has excellent anti-wrinkle treatment effect.

Claims (5)

1. a preparation method of Chinese medicine anti-wrinkle cosmetic cream, is characterized in that, It is made of seaweed, chuanxiong, peas, motherwort, salvia, ginkgo biloba, rice germ, grape seeds as raw materials, and uses seaweed pectin powder, polyethylene glycol 2000, benzyl alcohol, glycerin, Span 60, Tween 60, purified Water, white petrolatum, liquid paraffin, and carnauba wax are made into composite matrix, which are respectively prepared through the steps of extraction and purification, matrix melting, emulsification and dispersion, and filling; Specifically include the following steps: A. Extraction and purification: take water chestnut, chuanxiong, pea, motherwort, salvia, ginkgo biloba, rice germ, and grape seed as raw materials, respectively extract, purify, and dry to obtain extract powder for subsequent use; 8-12 parts of Chuanxiong, 5-9 parts of peas, 8-12 parts of Motherwort, 6-10 parts of Salvia miltiorrhiza, 6-10 parts of Ginkgo biloba, 5-9 parts of rice germ, 9-13 parts of grape seeds, based on weight ratio ; B. Matrix melting: take Ulva pectin powder, polyethylene glycol 2000, benzyl alcohol, glycerin, Span 60, Tween 60, and purified water and place them in a suitable container, heat to 60-80°C, and dissolve to obtain an aqueous phase The matrix is for subsequent use; another white vaseline, liquid paraffin, and carnauba wax are taken and placed in a suitable container, heated to 60-80 ° C, and dissolved to obtain an oil-phase matrix for subsequent use; 1 to 6 parts of polyethylene glycol 2000, 0.3 to 0.8 parts of benzyl alcohol, 0.5 to 1.2 parts of glycerin, 0.5 to 0.9 parts of Span 60, 1.2 to 1.8 parts of Tween 60, and 12 to 18 parts of purified water. In the matrix, 2-9 parts of white vaseline, 3-7 parts of liquid paraffin, and 8-13 parts of carnauba wax, by weight; C. Emulsifying and dispersing: Take the oil-phase matrix and the water-phase matrix obtained in step B, add the water-phase matrix to the oil-phase matrix under the condition of stirring and keep the temperature at 60~80℃, and stir while adding. Continue stirring for 10 to 20 minutes and stop the heat preservation, put it into ice water and cool it to 40 to 45 ° C and take it out, keep the temperature at 40 to 45 ° C and continue to stir, add the extract powder obtained in step A, while the Add and stir to make the extract powder evenly distributed, then add a pH adjuster to adjust the pH to 5.0~7.0, continue stirring and vacuum degassing until natural cooling, for use; D. Filling: fill according to suitable packaging specifications. 2. the preparation method of a kind of traditional Chinese medicine anti-wrinkle cosmetic cream as claimed in claim 1, is characterized in that, in step A, extract to take recipe quantity of water chestnut, chuanxiong, pea, motherwort, salvia, ginkgo biloba, rice germ, grape seed Mix and pulverize through a 60 mesh sieve, collect the powder, place it in a microwave extractor, add 50%~70% ethanol of 10 times the volume of the total mass of the mixed powder for microwave extraction, set the microwave power to 80KW~100KW, and the microwave extraction time For 30 to 60 minutes, after the extraction is completed, filter and collect the filtrate for use. 3. the preparation method of a kind of traditional Chinese medicine anti-wrinkle cosmetic cream as claimed in claim 2, is characterized in that, the purification step described in step A is to carry out ultra-fine filtrate with the polystyrene plastic film of 25000～35000 molecular weight cut-offs of the above-mentioned collected filtrate. Filtration treatment, the operating pressure is 0.3~0.5MPa, and the ultrafiltration temperature is 45~50℃ to obtain the ultrafiltrate. 4. the preparation method of a kind of Chinese medicine anti-wrinkle cosmetic cream as claimed in claim 3 is characterized in that, the drying step described in the step A is to place the ultrafiltrate collected above in a spray dryer to carry out spray drying, and is set to enter into a spray dryer. The air temperature is 190°C~210°C, the outlet air temperature is 60°C~80°C, the frequency of the Moruo pump is 10HZ~16HZ, the drying is completed, and the extract powder is collected. 5. the preparation method of a kind of traditional Chinese medicine anti-wrinkle cosmetic cream as claimed in claim 4 is characterized in that, the rotating speed of stirring described in step C is 60～90r/min, and the vacuum degree of described vacuum degassing is 0.05～0.08 MPa, the pH regulator is a sodium hydroxide solution of 0.1 mol/L to 0.5 mol/L, and the temperature of the water-phase matrix and the oil-phase matrix must be the same in the process that the water-phase matrix is added to the oil-phase matrix.