CN106727251A - A kind of natural bee venom gel frost and its preparation technology - Google Patents
A kind of natural bee venom gel frost and its preparation technology Download PDFInfo
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- CN106727251A CN106727251A CN201710093759.2A CN201710093759A CN106727251A CN 106727251 A CN106727251 A CN 106727251A CN 201710093759 A CN201710093759 A CN 201710093759A CN 106727251 A CN106727251 A CN 106727251A
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- bee venom
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- 239000003659 bee venom Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims description 7
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000000341 volatile oil Substances 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 8
- 244000178870 Lavandula angustifolia Species 0.000 claims description 8
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 8
- 240000003553 Leptospermum scoparium Species 0.000 claims description 8
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 8
- 229960001631 carbomer Drugs 0.000 claims description 8
- 239000001102 lavandula vera Substances 0.000 claims description 8
- 235000018219 lavender Nutrition 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 7
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims 2
- 244000044822 Simmondsia californica Species 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 11
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 10
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 6
- 102000008186 Collagen Human genes 0.000 abstract description 4
- 108010035532 Collagen Proteins 0.000 abstract description 4
- 102000016942 Elastin Human genes 0.000 abstract description 4
- 108010014258 Elastin Proteins 0.000 abstract description 4
- 229920001436 collagen Polymers 0.000 abstract description 4
- 229920002549 elastin Polymers 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000006071 cream Substances 0.000 description 89
- 239000000499 gel Substances 0.000 description 33
- 238000010521 absorption reaction Methods 0.000 description 19
- 208000002874 Acne Vulgaris Diseases 0.000 description 7
- 206010013786 Dry skin Diseases 0.000 description 7
- 206010000496 acne Diseases 0.000 description 7
- 230000037336 dry skin Effects 0.000 description 7
- 239000011148 porous material Substances 0.000 description 6
- 229940067596 butylparaben Drugs 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 108010036176 Melitten Proteins 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 229940119170 jojoba wax Drugs 0.000 description 4
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
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- 239000004480 active ingredient Substances 0.000 description 2
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- 229940053031 botulinum toxin Drugs 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000002435 venom Substances 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- 210000001048 venom Anatomy 0.000 description 2
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 102000015439 Phospholipases Human genes 0.000 description 1
- 108010064785 Phospholipases Proteins 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 241000221095 Simmondsia Species 0.000 description 1
- 206010040954 Skin wrinkling Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- -1 fatty acid esters Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000002596 immunotoxin Substances 0.000 description 1
- 231100000608 immunotoxin Toxicity 0.000 description 1
- 229940051026 immunotoxin Drugs 0.000 description 1
- 230000002637 immunotoxin Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- Oil, Petroleum & Natural Gas (AREA)
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- Dispersion Chemistry (AREA)
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Abstract
Description
技术领域technical field
本发明涉及化妆品领域，具体涉及一种天然蜂毒凝胶霜及其制备工艺The invention relates to the field of cosmetics, in particular to a natural bee venom gel cream and its preparation process
背景技术Background technique
蜂毒是工蜂毒腺和副腺分泌出一种的淡黄色透明毒液，具有抗炎镇痛，增强免疫等作用。蜂毒肽是蜂毒的主要活性成分，占蜂毒干重的50％,是蜂毒中主要发挥作用的物质。蜂毒肽分子质量小，由26个氨基酸组成,中间区域具有19个疏水性氨基酸残基，因其分子中存在2个脯氨酸残基和3个精氨酸残基，使其成为一个强碱性肽。蜂毒肽可增强磷脂酶2A活性，可直接进入细胞膜的脂质中间，改变膜的通透性，有效发挥生理活性作用，具有传统免疫毒素无法比拟的优势，这些特征为新性功能化妆品开发等方面提供了有利条件。Bee venom is a kind of light yellow transparent venom secreted by the venom glands and accessory glands of worker bees, which has anti-inflammatory, analgesic, and immune-enhancing effects. Melittin is the main active ingredient of bee venom, accounting for 50% of the dry weight of bee venom, and is the main substance in bee venom. The molecular mass of melittin is small, consisting of 26 amino acids, and the middle region has 19 hydrophobic amino acid residues, because of the presence of 2 proline residues and 3 arginine residues in the molecule, making it a strong Basic peptide. Melittin can enhance the activity of phospholipase 2A, can directly enter the lipid middle of the cell membrane, change the permeability of the membrane, and effectively exert its physiological activity. It has advantages that traditional immunotoxins cannot match. favorable conditions are provided.
蜂毒的抗炎活性很强，它是目前人类已知最强的抗菌消炎活性物质之一,其抗炎活性比氢化可的松高100倍。而且蜂毒肽是阳离子广谱抗菌肽，杀菌能力强，能够抑制多种细菌和阳性病原微生物的生长繁殖,蜂毒又被称为“天然肉毒素”，可以说是肉毒杆菌的替代品，文献中提及蜂毒液接触并轻蜇皮肤后，可以刺激人体内胶原蛋白和弹性蛋白，使皮肤达到紧致，平滑的目的。The anti-inflammatory activity of bee venom is very strong. It is one of the strongest anti-bacterial and anti-inflammatory active substances known to mankind. Its anti-inflammatory activity is 100 times higher than that of hydrocortisone. Moreover, melittin is a cationic broad-spectrum antibacterial peptide with strong bactericidal ability and can inhibit the growth and reproduction of various bacteria and positive pathogenic microorganisms. Bee venom is also called "natural botulinum toxin", which can be said to be a substitute for botulinum toxin. It is mentioned in the literature that after bee venom touches and stings the skin lightly, it can stimulate collagen and elastin in the human body, making the skin firm and smooth.
发明内容Contents of the invention
本发明目的在于提供一种天然蜂毒凝胶霜及其制备工艺,本发明目的是通过如下技术方案实现的：The object of the present invention is to provide a kind of natural bee venom gel cream and its preparation process, and the object of the present invention is realized through the following technical solutions:
本发明天然蜂毒凝胶的原料组成为：The raw material of natural bee venom gel of the present invention consists of:
本发明天然蜂毒凝胶的原料组成优选为：The raw material composition of natural bee venom gel of the present invention is preferably:
以上处方量均为质量分数；The above prescription quantities are all quality scores;
本发明的天然蜂毒凝胶的制备方法：The preparation method of natural bee venom gel of the present invention:
按照上述处方的质量分数，称重相应的物质，制备A,B,C,D四相。According to the mass fraction of the above prescription, weigh the corresponding substances to prepare four phases A, B, C, and D.
A相：蜂毒，十二烷基硫酸钠，三乙醇胺，纯净水Phase A: bee venom, sodium lauryl sulfate, triethanolamine, purified water
B相：甘油，1％透明质酸钠，尼泊金丁酯Phase B: Glycerin, Sodium Hyaluronate 1%, Butylparaben
C相：荷荷巴油，薰衣草精油，茶树精油，维生素EPhase C: jojoba oil, lavender essential oil, tea tree essential oil, vitamin E
D相：1％卡波姆溶液；Phase D: 1% carbomer solution;
将蜂毒溶解后，过膜，加入十二烷基硫酸钠，制得蜂毒溶液后，加入适量三乙醇胺，混合均匀得到A相；称取尼泊金丁酯，加入甘油和1％透明质酸钠溶液，混匀得到B相；称取处方量的荷荷巴油，薰衣草精油，茶树精油，维生素E，混匀得到C相；称取处方量的1％卡波姆溶液为D相；Dissolve the bee venom, pass through the membrane, add sodium lauryl sulfate to prepare the bee venom solution, add an appropriate amount of triethanolamine, mix well to obtain phase A; weigh butylparaben, add glycerin and 1% hyaluronic acid Sodium bicarbonate solution, mixed evenly to obtain phase B; weighed jojoba oil, lavender essential oil, tea tree essential oil, vitamin E, and mixed to obtain phase C; weighed 1% carbomer solution of prescribed amount as phase D;
将A相加入到D相中，充分搅拌，混匀，少量多次加入B相，并不停搅拌，待混合均匀后，加入C相，混合后即得到本发明产品。Add phase A into phase D, stir well, mix well, add a small amount of phase B several times, keep stirring, after mixing evenly, add phase C, after mixing, the product of the present invention is obtained.
本发明凝胶霜相较于传统材质的霜，水溶性水凝胶呈现出类似果冻的状态，使有效成分包裹其中，具有不易蒸发、干燥、清凉舒缓的效果，对急性皮肤损伤(如过敏、长痘、擦伤)有良好效果。以卡波姆为基质制作的凝胶剂具有易涂展，无油腻性，附着性和均匀性良好，对皮肤和黏膜无刺激性、不污染衣物，且使药物呈零级或近似零级释放的特点。Compared with the cream of traditional materials, the gel cream of the present invention presents a state similar to jelly, so that the active ingredients are wrapped in it, and has the effect of not being easy to evaporate, dry, cool and soothing, and has the effect on acute skin damage (such as allergies, Acne, abrasions) have a good effect. The gel made of carbomer is easy to spread, non-greasy, good adhesion and uniformity, non-irritating to the skin and mucous membranes, does not pollute the clothes, and makes the drug release in zero or near zero order specialty.
本发明凝胶霜利用卡波姆形成水凝胶替代了传统的霜，凝胶具有亲水性更强，而且具有较好的生物相容性。The gel cream of the present invention uses carbomer to form a hydrogel to replace the traditional cream, and the gel has stronger hydrophilicity and better biocompatibility.
本发明凝胶霜用于改善皮肤毛孔粗大，改善皮肤皱纹，皮肤干燥，长痘等肌肤问题。便于携带，使用方便，吸收性能良好，显著解决了油质，脂肪酸酯等化妆品涂抹之后皮肤油腻，毛孔堵塞等问题。为了增强抗炎，祛痘的功效，在处方中除了有蜂毒外，还添加了具有抗炎祛痘的精油成分，如茶树精油，薰衣草精油。The gel cream of the invention is used for improving skin pores, skin wrinkles, dry skin, acne and other skin problems. It is easy to carry, easy to use, and has good absorption performance, which significantly solves the problems of greasy skin and clogged pores after applying cosmetics such as oily and fatty acid esters. In order to enhance the anti-inflammatory and anti-acne effects, in addition to bee venom, the prescription also adds anti-inflammatory and anti-acne essential oils, such as tea tree essential oil and lavender essential oil.
本发明凝胶霜利用蜂毒抗菌，消炎的功效，刺激人体产生胶原蛋白和弹性蛋白，使皮肤达到紧致，平滑的作用明显，为公众护肤品的选择提供了新方向。The gel cream of the invention utilizes the antibacterial and anti-inflammatory effects of the bee venom to stimulate the human body to produce collagen and elastin, so that the skin can be tightened and smoothed, which provides a new direction for the public to choose skin care products.
下述试用例和实施例用于进一步说明但不限于本发明The following trial examples and embodiments are used to further illustrate but not limit the present invention
本发明凝胶霜(实施例1制备)试用实验，受试者20名，清洁面部后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用蜂毒霜后20例均无不适现象，试用霜3-7天后，肌肤水润。Gel cream of the present invention (prepared in Example 1) trial experiment, 20 test subjects, after cleaning the face, apply the bee venom cream on the skin and pat it gently to absorb, and there is no discomfort in 20 cases after the trial use of the bee venom cream , After trying the cream for 3-7 days, the skin is moisturized.
试用例1Trial example 1
受试者为正常皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用蜂毒霜后20例均无不适现象，试用霜7天后，肌肤水润。The subjects had normal skin. After cleansing the skin, apply the bee venom cream on the skin and pat it gently to absorb it. After trying the bee venom cream, 20 cases had no discomfort. After 7 days of using the cream, the skin was moisturized.
试用例2本发明凝胶霜试用实验：Trial example 2 Gel cream trial experiment of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润，而且可以使毛孔缩小。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, the skin felt moisturized and the pores were shrunk. The subjects had no discomfort after trying the bee venom cream.
试用例3本发明凝胶霜试用实验：Trial example 3 Gel cream trial experiment of the present invention:
受试者敏感性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润。受试者试用蜂毒霜后无不适现象。The subject has sensitive skin. After cleansing the skin, apply the bee venom cream on the skin and pat it gently for absorption. After 7 days of trial use, the skin feels moisturized. The subjects had no discomfort after trying the bee venom cream.
试用例4本发明凝胶霜试用实验：Trial example 4 Gel cream trial experiment of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润，使毛孔缩小。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After 7 days of using the cream, the skin felt moist and the pores narrowed. The subjects had no discomfort after trying the bee venom cream.
试用例5本发明凝胶霜试用实验：Trial example 5 Gel cream trial experiment of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润，改善皮肤起痘问题。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, the skin felt moisturized and the skin acne problem improved. The subjects had no discomfort after trying the bee venom cream.
试用例6本发明凝胶霜试用实验：Trial example 6 Gel cream trial experiment of the present invention:
受试者干性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜3天后，改善皮肤起痘现象。受试者试用蜂毒霜后无不适现象。The subject has dry skin, after cleaning the skin, apply the bee venom cream on the skin and pat it gently for absorption. After 3 days of using the cream, the skin acne phenomenon has improved. The subjects had no discomfort after trying the bee venom cream.
试用例7本发明凝胶霜试用实验：Trial example 7 Gel cream trial experiment of the present invention:
受试者干性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润。受试者试用蜂毒霜后无不适现象。Subjects with dry skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, the skin felt moisturized. The subjects had no discomfort after trying the bee venom cream.
试用例8本发明凝胶霜试用实验：Trial example 8 Gel cream trial experiment of the present invention:
受试者干性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润。受试者试用蜂毒霜后无不适现象。Subjects with dry skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, the skin felt moisturized. The subjects had no discomfort after trying the bee venom cream.
试用例9本发明凝胶霜试用实验：Trial example 9 Gel cream trial experiment of the present invention:
受试者油性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜3天后，使肌肤更加水润。受试者试用蜂毒霜后无不适现象。The subjects with oily skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After using the cream for 3 days, the skin became more hydrated. The subjects had no discomfort after trying the bee venom cream.
试用例10本发明凝胶霜试用实验：Trial example 10 Gel cream trial experiment of the present invention:
受试者干性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，涂抹霜20分钟后清洗面部。试用霜7天后，感到肌肤水润，而且减少了面部细纹。受试者试用蜂毒霜后无不适现象。The test subject has dry skin. After cleansing the skin, apply the bee venom cream on the skin and pat it gently for absorption. After applying the cream for 20 minutes, wash the face. After trying the cream for 7 days, my skin feels hydrated and fine lines on my face are reduced. The subjects had no discomfort after trying the bee venom cream.
试用例11本发明凝胶霜试用实验：Trial example 11 Trial experiment of gel cream of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润，改善面部起痘现象。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, the skin felt moisturized and the appearance of acne on the face was improved. The subjects had no discomfort after trying the bee venom cream.
试用例12本发明凝胶霜试用实验：Trial example 12 Trial experiment of gel cream of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜15天后，感到肌肤水润，保湿效果较好。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After 15 days of trial, the skin felt moist and the moisturizing effect was better. The subjects had no discomfort after trying the bee venom cream.
试用例13本发明凝胶霜试用实验：Trial example 13 Gel cream trial experiment of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润，而且可以改善皮肤起痘症状。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, they felt that the skin was moisturized and the skin acne symptoms could be improved. The subjects had no discomfort after trying the bee venom cream.
试用例14本发明凝胶霜试用实验：Trial example 14 Trial experiment of gel cream of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After 7 days of trial use, the skin felt moisturized. The subjects had no discomfort after trying the bee venom cream.
试用例15本发明凝胶霜试用实验：Trial example 15 Trial experiment of gel cream of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜3天后，感到肌肤水润，使用时间15天以上，可以改善皮肤起痘症状。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After using the cream for 3 days, the skin felt moisturized. After using it for more than 15 days, the skin acne symptoms can be improved. The subjects had no discomfort after trying the bee venom cream.
试用例16本发明凝胶霜试用实验：Trial example 16 Trial experiment of gel cream of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After 7 days of trial use, the skin felt moisturized. The subjects had no discomfort after trying the bee venom cream.
试用例17本发明凝胶霜试用实验：Trial example 17 Trial experiment of gel cream of the present invention:
受试者干性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润，而且可以使毛孔缩小。受试者试用蜂毒霜后无不适现象。Subjects with dry skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, they felt that the skin was moist and the pores could be shrunk. The subjects had no discomfort after trying the bee venom cream.
试用例18本发明凝胶霜试用实验：Trial example 18 Trial experiment of gel cream of the present invention:
受试者干性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜3天后，感到肌肤水润，保湿效果较好。受试者试用蜂毒霜后无不适现象。The subject has dry skin, after cleansing the skin, apply the bee venom cream on the skin and pat it gently to absorb it. After using the cream for 3 days, the skin feels moist and the moisturizing effect is better. The subjects had no discomfort after trying the bee venom cream.
试用例19本发明凝胶霜试用实验：Trial example 19 Trial experiment of gel cream of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜7天后，感到肌肤水润，而且可以使毛孔缩小。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After trying the cream for 7 days, the skin felt moisturized and the pores were shrunk. The subjects had no discomfort after trying the bee venom cream.
试用例20本发明凝胶霜试用实验：Trial example 20 Gel cream trial experiment of the present invention:
受试者混合性皮肤，清洁皮肤后，将蜂毒霜涂在皮肤上轻轻拍打即可吸收，试用霜3天后，感到肌肤水润。受试者试用蜂毒霜后无不适现象。Subjects with mixed skin, after cleansing the skin, applied the bee venom cream on the skin and patted it gently for absorption. After 3 days of using the cream, the skin felt moisturized. The subjects had no discomfort after trying the bee venom cream.
下述实施例均能实现上述试用例所述的效果The following embodiments can all realize the effects described in the above-mentioned trial examples
具体实施方式detailed description
实施例1：凝胶霜的制备Embodiment 1: the preparation of gel cream
本发明的天然蜂毒凝胶的制备方法：The preparation method of natural bee venom gel of the present invention:
按照上述处方的质量分数，称重相应的物质，制备A,B,C,D四相。According to the mass fraction of the above prescription, weigh the corresponding substances to prepare four phases A, B, C, and D.
A相：蜂毒，十二烷基硫酸钠，三乙醇胺，纯净水Phase A: bee venom, sodium lauryl sulfate, triethanolamine, purified water
B相：甘油，1％透明质酸钠，尼泊金丁酯Phase B: Glycerin, Sodium Hyaluronate 1%, Butylparaben
C相：荷荷巴油，薰衣草精油，茶树精油，维生素EPhase C: jojoba oil, lavender essential oil, tea tree essential oil, vitamin E
D相：1％卡波姆溶液；Phase D: 1% carbomer solution;
将蜂毒溶解后，过膜，加入十二烷基硫酸钠，制得蜂毒溶液后，加入8滴三乙醇胺，混合均匀得到A相；称取尼泊金丁酯，加入甘油和1％透明质酸钠溶液，混匀得到B相；称取处方量的荷荷巴油，薰衣草精油，茶树精油，维生素E，混匀得到C相；称取处方量的1％卡波姆溶液为D相；After dissolving the bee venom, pass through the membrane, add sodium lauryl sulfate to prepare the bee venom solution, add 8 drops of triethanolamine, mix well to obtain phase A; weigh butylparaben, add glycerin and 1% transparent Sodium hyaluronate solution, mix well to get phase B; weigh the prescribed amount of jojoba oil, lavender essential oil, tea tree essential oil, vitamin E, and mix evenly to get phase C; weigh the prescribed amount of 1% carbomer solution as phase D ;
将A相加入到D相中，充分搅拌，混匀，少量多次加入B相，并不停搅拌，待混合均匀后，加入C相，混合后即得到本发明产品。Add phase A into phase D, stir well, mix well, add a small amount of phase B several times, keep stirring, after mixing evenly, add phase C, after mixing, the product of the present invention is obtained.
上述配方中，蜂毒具有抗炎，抗菌，刺激人体产生胶原蛋白和弹性蛋白，使皮肤达到紧致，平滑的作用；甘油具有保湿润肤的功效；透明质酸钠具有保湿作用，荷荷巴油具有滋润，紧致肌肤，软化脂肪等护肤功效；薰衣草精油具有清热解毒，清洁皮肤，控制油分，祛斑美白，祛除黑眼圈，还可促进受损组织再生恢复等护肤功能；茶树精油具有杀菌消炎的功效；尼泊金丁酯作为处方中的防腐剂。In the above formula, bee venom has anti-inflammatory and antibacterial properties, stimulates the body to produce collagen and elastin, and makes the skin firm and smooth; glycerin has the effect of moisturizing and emollient; sodium hyaluronate has moisturizing effect, jojoba The oil has skin care effects such as moisturizing, firming the skin, and softening fat; lavender essential oil has skin care functions such as clearing away heat and detoxification, cleaning the skin, controlling oil content, removing freckles, whitening, removing dark circles, and promoting the regeneration and recovery of damaged tissues; tea tree essential oil has bactericidal and anti-inflammatory properties efficacy; butylparaben as a preservative in prescriptions.
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