CN1073577A - Compound iodine - Google Patents
Compound iodine Download PDFInfo
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- CN1073577A CN1073577A CN 91106886 CN91106886A CN1073577A CN 1073577 A CN1073577 A CN 1073577A CN 91106886 CN91106886 CN 91106886 CN 91106886 A CN91106886 A CN 91106886A CN 1073577 A CN1073577 A CN 1073577A
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- iodine
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- compound iodine
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Abstract
The compound iodine belongs to a disinfectant containing iodine. The invented compound iodine not only contains polyvinylpyrrolidone, iodine, alcohol solvent and surfactant, but also contains beta-cyclodextrin, the PVP content is 0.005-20% by total weight, the beta-cyclodextrin content is 0.01-1.8% by total weight and the iodine content is 0.005-6% by total weight. The compound iodine has the advantages of good sterilization effect, wide sterilization spectrum, good stability, small irritation, slight yellow dyeing, easy fading, less foam, low viscosity, high iodine utilization rate and low price, and is a novel sterilization agent with wide application prospect.
Description
Compound iodine belongs to a kind of disinfectant composition that contains iodine.
Iodophor is the iodine succeeded in developing of external the fifties and the complex compound of carrier, iodine is contained in the surfactant micelle, concentrated solution free-iodine content is low, but dilute solution iodine slowly-releasing comes out, therefore the bactericidal action of Iodophor is lasting, excitant is low, and xanthochromia slightly easily disappears and takes off, and abroad has been widely used in the skin degerming of operative site, injection site and hand and has been used for gynaecology's flushing and the sterilization of external device, food instrument, air and drinking-water etc.Domestic also have several Iodophors to come out in recent years, uses also extensive day by day.Number of patent application is the 88107906.5 disclosed iodine microbicide compositions that contain, and is the complex compound of polyvinylpyrrolidone and iodine, and solvent is the mixture of C1-C3 lower alcohol or lower alcohol and a kind of non-hydrated polyol, and its consumption accounts for more than 80% of total composition.Like this contain the sterilization that iodine microbicide should not be used for human body skin and oral mucosa, and must in special container, preserve and just present certain stability.
The present invention is intended to develop a kind of Iodophor, and not only fungicidal spectrum is wide, germicidal efficiency is high, good stability, and also toxicity is slighter, and viscosity is little, foam is few, and is cheap, easy to use.
The technical scheme that realizes task of the present invention is: remove in the compound iodine and contain polyvinylpyrrolidone, iodine, outside alcohols solvent and the surfactant, also contain cycloheptaamylose, be with polyvinylpyrrolidone, cycloheptaamylose is that carrier and cosolvent and iodine complexing form, wherein the content of polyvinylpyrrolidone is counted 0.005-20%(weight by the compound iodine total amount), with 0.1-10% is good, the content of cycloheptaamylose is counted 0.001-1.8% by the compound iodine total amount, the suitableeest scope is 0.05-1.0%, and it is 0.1-3% that the content of iodine is counted the suitableeest scope of 0.005-6% by the compound iodine total amount; Alcohols solvent in the compound iodine is that the mixture of a kind of lower alcohol and polyalcohol or the content of single polyalcohol are counted 0.5-10% by the compound iodine total amount, and the surfactant in the compound iodine has paraffin sulfonate, alkylbenzenesulfonate and long-chain fat acid metal salt.
Be described in further detail the present invention below.
Compound iodine is with polyvinylpyrrolidone (PVP), and cycloheptaamylose is that carrier and cosolvent and iodine complexing form, and iodine is contained among the PVP, the outside is wrapped up in cycloheptaamylose (β-CO), the toxicity of iodine is reduced, and also further increase of stability, cost also decreases.The tool synergistic effect in compound iodine of the mixture of lower alcohol and polyalcohol or single polyalcohol, the 0.5-10% of its content meter total amount, lower alcohol is generally ethanol, and polyalcohol is a propane diols; The compound iodine that is used as cleaning treatment can add the surfactant such as the paraffin sulfonate of debita spissitudo, alkylbenzenesulfonate and long-chain fat acid metal salt; The compound iodine that is used for the burn wound processing should add some glucides, to promote to organize granulation new life preferably.The compound iodine that is used for skin, mucous membrane sterilization can adopt following prescription:
PVP 2%
12 1%
β-CO 0.5%
Propane diols 1%
The prescription that is used for the compound iodine of article, machinery cleaning is:
PVP 3%
12 1.2%
β-CO 0.6%
Ethanol 1%
Surfactant 0.1%
The prescription that is used for the compound iodine of burn wound, wound disinfection is:
PVP 2%
12 0.6%
β-CO 0.3%
Glucose 20%
The compound iodine stability that the present invention proposes further improves, and the at room temperature monthly rate of descent of 0.5% compound iodine is 0.039%, and average annual rate of descent is 0.47%; 1.0% compound iodine is stored a year and a half quite stable still, does not see that content descends by (table one), has both made under 42 ± 1 ℃ temperature condition, and available iodine content is that the day rate of descent of the compound iodine of 5000PPN only is 0.27%(table two).
Table 1 compound iodine is stored the different time available iodine content
Period of storage available iodine content (PPm)
(my god) content decline degree (%) content rate of descent (%)
0 5250 0 10500 0
1 5240 0.19 10480 0.19
5 5240 0.19 10500 0
7 5250 0 10500 0
15 5240 0.19 10500 0
30 5210 0.7 10500 0
60 5210 0.7 10500 0
120 5210 0.7 10500 0
360 5210 0.7 10500 0
540 5210 0.7 10500 0
Monthly rate of descent is 0.039%, and average annual rate of descent is 0.47%.
The stability that table 2 compound iodine is stored under the different temperatures variable concentrations
Store available iodine content (PPm)
Temperature-time
℃ sky 500 rate of descent %, 1000 rate of descent %, 5000 rate of descent %
20±1 1 500 0 1000 0 5000 0
5 480 4 1000 0 5000 0
10 460 8 9970 3 5000 0
15 450 10 9930 7 5000 0
20 420 16 9930 7 5000 0
42℃±1 1 460 8 1000 0 5000 0
5 450 10 1000 0 5000 0
10 417.5 16.7 923 7.7 4860 2.8
15 335 33 923 7.7 4730 5.4
20 335 33 923 7.7 4730 5.4
Compound iodine is a kind of wide spectrum, antiseptic sterilization agent efficiently, and through a large number of experiments show that, its aqueous solution all has stronger killing action to bacterial propagule, brood cell, virus, fungi and mycotic spore.Be 5 minutes the fastest effective time that staphylococcus aureus is killed, and minimal effective concentration is 6.25PPm, and be 5 minutes the fastest effective time that colibacillus is killed, and minimal effective concentration is 12.5PPm, and killing rate is 100%(table 3, table 4)
The qualitative bacterial propagule result of the test of killing of table 3 compound iodine
Available iodine ATCC-6538 Escherichia coli (8099 strain)
Concentration (PPm) action time (branch) action time (branch)
5 10 15 30 60 5 10 15 30 60
1.56 + + + + + + + + + +
3.12 + - - - - + + + + +
6.25 - - - - - + + + - -
12.5 - - - - - - - - - -
25 - - - - - - - - - -
50 - - - - - - - - - -
Positive control++
The Pei Ji contrast--
Annotate: "+" expression has bacteria growing in the table, and "-" expression asepsis growth is five result of the tests in the table.
Be 30 minutes the fastest effective time that bacillus subtilis black variety bud cell is killed, minimal effective concentration is a 500PPm(table 5), contain the compound iodine effect 10 minutes of available iodine 500PPm, killing rate to withered black brood cell reaches 99.9940%, and available iodine content is that 10 minutes killing rates to wax shape brood cell of 125PPm compound iodine effect reach 99.9992%
The qualitative brood cell's effect of killing of table 5 compound iodine
Available iodine is to ATCC-9372 action time (branch) and result
Concentration (PPm)
5 10 15 30 60
62.5 + + + + +
125 + + + + -
250 + + + + -
500 + + + - -
1000 - - - - -
Positive control+
The Pei Ji contrast-
Annotate: in the table "+" for bacteria growing is arranged, "-" be asepsis growth, warp shows that to hepatitis type B virus deactivation mensuration 10 minutes destructive rates to pure HBsAg of 500PPm compound iodine effect reach 100%(table 6)
Table 6 compound iodine is to the destruction situation of HBsAg
Available iodine action time (branch) and killing rate (%)
Concentration (PPm)
5 minutes 10 minutes 30 minutes 60 minutes
62.5 38.7 53.3 66.7 68.4
125 52.3 85.6 98.3 100
250 78.7 89.3 97.2 100
500 93.6 100 100 100
Test repeats 5 times
0.5% compound iodine is 97.33-100% to the sterilizing rate of hand skin natural bacteria, average out to 99.90%.
Compound iodine is used for the cleaning of medical article, apparatus, the results showed with 0.5% compound iodine immersion treatment, its ultimate strengths of fabric such as cotton chemical fibre and contrast difference are not remarkable, showing does not almost have damage to fabric, place 0.5% compound iodine solution continuous dipping to take out after 8 days on metal, show that compound iodine has the mild oxidation effect to copper, charcoal steel, but aluminium and stainless steel are not had the damage effect.Latex caliber 0.5% compound iodine is soaked 50 times, its hardness, and the elasticity no change, flawless is not clamminess, and just color has reinforcement slightly after soaking for the first time, but further intensification is not seen in each time later on.
Compound iodine is as antiseptic sterilization agent, for different sterilization position and objects, and the usage difference, consumption also differs, and must measure available iodine content (seeing Table 7) before using
The usage of table 7 compound iodine and consumption
Contain effectively with stoste
Sterilization objects available iodine content iodine 5000PPm meter disinfection way action time
(PPm) extension rate of Suaning
Operation and injection
Skin degerming 5000 usefulness stostes in position are embrocated 2 times 2
Oral mucosa is sterilized and 500 10 is embrocated or wash
Vagina mucosa sterilize 250 20 the flushing
Burn, wound sterilization 250-500 10-20 embrocate or wash
The patient washes one's hands and 500 10 soaks 2
Medical apparatus sterilizing 250-500 10-20 soaks 30-60
Tableware, tea set sterilization 100-200 25-50 soak 10-20
Vegetable and fruit sterilization 100-200 25-50 soaks 2-5
The clothing 250-500 10-20 of patient contamination soaks 30-60
Equipment disinfection
Not only sterilization is rapid for compound iodine in sum, bactericidal effect is good, fungicidal spectrum is wide, good stability, stimulate little, xanthochromia slightly easily disappears and takes off, and iodine availability height, and the iodine availability is up to 95% in the compound iodine, and the availability of iodine only about 85% in the general Iodophor, save raw material, the Iodophor carrier is many by external import, and price is more expensive, and the used import carrier of compound iodine only other Iodophor 1/3, therefore also reduced cost, the compound iodine foam is few simultaneously, viscosity is low, good fluidity, is a kind of novel antiseptic sterilization agent with broad prospect of application.
Claims (5)
1, a kind of wide spectrum, efficiently contain iodine antiseptic sterilization agent-compound iodine, contain polyvinylpyrrolidone (PVP), iodine, alcohols solvent, surfactant, feature of the present invention also is to contain in the compound iodine cycloheptaamylose, be with polyvinylpyrrolidone, cycloheptaamylose is that carrier and cosolvent and iodine complexing form, wherein the content of polyvinylpyrrolidone is counted 0.005-20% (weight) by the compound iodine total amount, the content of cycloheptaamylose is counted 0.001-1.8% by the compound iodine total amount, and the content of iodine is counted 0.0005-6% by the compound iodine total amount.
2, by the described compound iodine of claim 1, it is characterized in that alcohols solvent is the mixture of a kind of lower alcohol and polyalcohol or single polyalcohol.
3, by the described compound iodine of claim 2, it is characterized in that lower alcohol is an ethanol, polyalcohol is a propane diols.
4,, it is characterized in that the mixture of lower alcohol and polyalcohol or the content of polyalcohol counts 0.5-10% by the compound iodine total amount by claim 2 or 3 described compound iodine.
5, by the described compound iodine of claim 1, it is characterized in that surfactant has paraffin sulfonate, alkylbenzenesulfonate and long-chain fat acid metal salt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91106886 CN1073577A (en) | 1991-12-23 | 1991-12-23 | Compound iodine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91106886 CN1073577A (en) | 1991-12-23 | 1991-12-23 | Compound iodine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1073577A true CN1073577A (en) | 1993-06-30 |
Family
ID=4908264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91106886 Pending CN1073577A (en) | 1991-12-23 | 1991-12-23 | Compound iodine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1073577A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998047373A1 (en) * | 1997-04-24 | 1998-10-29 | Basf Aktiengesellschaft | Liquid iodophor from poly-n-vinyl lactam, dextrine and alcohols |
| CN1069824C (en) * | 1997-01-07 | 2001-08-22 | 汪素萍 | Multi-effect body lotion containing iodine |
| CN102349541A (en) * | 2011-08-10 | 2012-02-15 | 寇志民 | New application of iodine cyclodextrin inclusion compound |
| CN101987109B (en) * | 2009-08-05 | 2012-07-04 | 天津金耀集团有限公司 | Ophthalmic composition containing povidone iodine and cyclodextrin included glucocorticoid |
| CN107518001A (en) * | 2017-09-01 | 2017-12-29 | 四川创美克科技有限公司 | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof |
-
1991
- 1991-12-23 CN CN 91106886 patent/CN1073577A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069824C (en) * | 1997-01-07 | 2001-08-22 | 汪素萍 | Multi-effect body lotion containing iodine |
| WO1998047373A1 (en) * | 1997-04-24 | 1998-10-29 | Basf Aktiengesellschaft | Liquid iodophor from poly-n-vinyl lactam, dextrine and alcohols |
| CN101987109B (en) * | 2009-08-05 | 2012-07-04 | 天津金耀集团有限公司 | Ophthalmic composition containing povidone iodine and cyclodextrin included glucocorticoid |
| CN102349541A (en) * | 2011-08-10 | 2012-02-15 | 寇志民 | New application of iodine cyclodextrin inclusion compound |
| CN107518001A (en) * | 2017-09-01 | 2017-12-29 | 四川创美克科技有限公司 | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof |
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