CN107349309A - A kind of compound bavin head red sage root anti-liver cancer and anti-oral liquids and its preparation technology - Google Patents

Abstract

A kind of compound bavin head red sage root anti-liver cancer and anti-oral liquids of the present invention and its preparation technology, by formulations of compound bavin head red sage root anti-liver cancer and anti-oral liquid prescriptions, materials procurement, raw material processing, raw material tcm and herbal slice extracts active ingredients, prepare it is canned, sterilize, the multiple working procedure such as pack and machine；Compound bavin head red sage root anti-liver cancer and anti-s oral liquid prescription is formulated：Bavin is first 35 grams, 5 kinds of 30 grams of red sage root etc., honey and distillation water consumption, and by 5: 5 volume measurements, preservative dosage 0.1%, the buying ratio of 75% alcohol solvent and tcm and herbal slice total amount is 2: 1；Raw material tcm and herbal slice extracts active ingredients, the patent of invention (July 3 2017 applying date) " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " designed using the applicant, applied carries out seepage pressure effects, extract solution adds auxiliary material to be mixed evenly, with 200 milliliters of volume oral liquid bottles carry out it is canned, pack, it is oral 20 milliliters every time, twice a day.

Description

A kind of compound bavin head red sage root anti-liver cancer and anti-oral liquids and its preparation technology

Technical field

A kind of compound bavin head red sage root anti-liver cancer and anti-oral liquids of the present invention and its preparation technology category anti-tumor Chinese herbal preparation prepare neck Domain, more particularly to a kind of compound bavin head red sage root anti-liver cancer and anti-oral liquids and its preparation technology.

Background technology

Liver cancer is one of kinds of tumor disease, and its male's incidence of disease accounts for the 3rd, and the women incidence of disease accounts for the 5th, at present disease Because still uncertain, may with chronic hepatitis, chemical carcinogen, inherent cause, excessive consumption of alcohol, it is improper diet, have a violent temper and lose Biography factor etc. is relevant, this sick early symptom unobvious, may there is that diet is bad, stomach receives decline, upper abdomen turgor etc., followed by hepatic region The symptom developments such as lump, hepatic region pain, weight loss, heating, jaundice；This disease is classified as the categories such as " liver product ", " accumulation " by the traditional Chinese medical science, Because of hepatic insufficiency, exopathogen invasion and attack, cause qi depression to blood stasis, gather " blocking ".This disease is divided into caused by hepatic stagnation qi stagnation, the damp and hot stasis of blood simultaneously Malicious type, liver-kidney yin deficiency etc., during using Chinese traditional treatment, this disease of preferably assaulting the main target, whole body is nursed one's health, is treated both principal and secondary aspect of disease, with up to purpose；The present invention 6 kinds of tcm and herbal slice compositing formulas such as bavin head, the red sage root, the tuber of pinellia, radix scutellariae, glycyrrhiza glabra, honey are selected, it is first red to be prepared into compound bavin Join anti-liver cancer and anti-oral liquid, effect is complementary, and effect is extensive, is often drunk by the course for the treatment of, along with necessary dietary adjustments and physical training, together When adjust psychological quality, one surely makes liver tumour patient play treatment, health-care effect, mitigates patient mental's burden, improves patient Quality of life.

The content of the invention

The purpose of the present invention is：Select 6 kinds of tcm and herbal slice groups such as bavin head, the red sage root, the tuber of pinellia, radix scutellariae, glycyrrhiza glabra, honey Into formula, a kind of compound bavin head red sage root anti-liver cancer and anti-oral liquids are made, there is antitumor, reducing blood lipid, hypotensive, hypoglycemic, drop body Weight, eliminating blood stasis and removing ecchymoses, strengthen the multiple functions such as immune.6 kinds of tcm and herbal slice effects are complementary, and effect is extensive, is often drunk by the course for the treatment of, then add Upper necessary dietary adjustments and physical training, while psychological quality is adjusted, one surely makes liver tumour patient play treatment, health care work With, mitigation patient mental's burden, raising patients ' life quality.

To achieve these goals, the technical solution adopted by the present invention is：A kind of compound bavin head red sage root anti-liver cancer and anti-oral liquids Preparation technology, formulated by oral liquid prescription, materials procurement, raw material processing, raw material extracts active ingredients, extraction medicine add water Stirring precipitation, oral liquid are prepared, oral liquid filling sterilizes, label is pasted and packaging multiple working procedure machines；Compound bavin is first red Join anti-liver cancer and anti-oral liquid prescription to formulate：Bavin is first 35 grams, 30 grams of the red sage root, 20 grams of the tuber of pinellia, 20 grams of radix scutellariae, 5 grams of glycyrrhiza glabra, honey with It is equal to distill water consumption, by 5: 5 volume measurements, preservative dosage 0.1%, 75% alcohol solvent is that tcm and herbal slice (removes honey Similarly hereinafter) 2 times of total amount；Materials procurement：First determine that compound bavin head red sage root anti-liver cancer and anti-oral liquids this batches always produces total bottle number, every Bottle capacity, production total capacity, every bottle take number of days, take total number of days, then going out 6 kinds of tcm and herbal slices by recipe calculation and need to use daily Amount, calculates 6 kinds of total expenses of tcm and herbal slice, total expense calculates every kind of Chinese medicine by formula rate by total number of days is taken The expense of medicine materical crude slice, graded kind are purchased, and the various tcm and herbal slices of buying have to comply with the quality of every kind of tcm and herbal slice Index and specification standards, without go mouldy, it is no disease and pests harm, free from admixture, pollution-free；75% etoh solvent is purchased and tcm and herbal slice total amount Buying ratio is 2: 1；Raw material are processed：In addition to honey, preservative, distilled water, every kind of tcm and herbal slice is carried out selected and dried in the air Shine, after being sufficiently mixed uniformly, first crushed with 8 millimeters of particle diameter pulverizers, then it is standby with 4 millimeters of particle diameter pulverizers crushing；Raw material Tcm and herbal slice extracts active ingredients, ethanol extract from water precipitation is taken to carry out, the patent of invention (Shen designed using the applicant, applied Please July 3 2017 day) " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " carry out diacolation and carry Take；The device is by percolating extractor support, suit cylinder percolating device, electric pump circulatory displacement device, the automatic mistake of diacolation solution Filter device, temperature automatically controlled hot water circulating heating device, diacolation solvent evaporating separation device, diacolation solvent condensate recycling device seven It is grouped into；The percolating extractor operation technological process is：Closing diacolation solution control valve 1.-→ opening charging closure-→ - → layering that meter feedstock is fitted into inner cylinder, which is fitted into uniform-→ the addition diacolation solvent of actual situation, drenches in circular groove-→ circular groove and is slowly added to ooze Solvent-→ solvent of filtering uniformly drench pushed down into raw material-→ circular groove not float-→ solvent adds to and no longer drenches into 5 centimetres away from circular groove bottom Only circular hole in the middle part of closure is rotated to drenching and diacolation solution circulation pump-→ regulation diacolation solution is opened into circular groove inner edge-→ follows by-→ Ring valve do not make diacolation solution overflow stop-→ close diacolation solution circulation pump-→ close charging closure penetrate screw tightening-→ it is quiet Putting diacolation 36 hours ,-→ opens diacolation solution circulation pump circulatory displacement 36 hours-→, and closing diacolation solution circulation pump-→ opening is oozed Filter solution control valve-→ diacolation solution through the screen pack automatic fitration of internal barrel bottom-→ through diacolation solution control valve-→ flow into diacolation Solution evaporative cylinder top screen pack natural filtration-→ filtered fluid inflow diacolation solution evaporative cylinder bottom-→ opening charging closure- → open diacolation solution circulation pump-→ and determine whether internal barrel bottom screen pack filters and terminate-→ 2. to terminate filtering that to close diacolation molten Hydraulic control valve-→ addition new diacolation solvent-→ progress secondary cycle seepage pressure effects (operating process is identical with first time)-→ secondary - → opens diacolation solution control valve-→ secondary diacolation solution through the automatic mistake of internal barrel bottom screen pack after the completion of circulatory displacement extraction Filter-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ secondary diacolation solution and flowed under diacolation solution evaporative cylinder Portion's-→ with first time diacolation solution mix-→, which 3. takes out inner cylinder and pours out dregs of a decoction cleaning-→ inner cylinder, is reentered into outer barrel-→ closing Diacolation solution control valve-→ meter feedstock loads inner cylinder-→ and enters next seepage pressure effects program-→ secondary diacolation solution evaporative cylinder Self-filtering net filtration, which terminates ,-→ 4. connect water source-→ to boiler, hot water storgae, condenser adds water-→ to open electromagnetic stove to heat Heating water tanks-→ unlatching hot water circulating pump-→ boiler starts the cycle over-→ with hot water storgae hot water and added to diacolation solution evaporative cylinder Heat-→ 5. opens automatic temperature control instrument-→ regulation temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature and rises to 90 DEG C Electromagnetic stove closes automatically-→ hot water storgae water temperature be down to 80 DEG C of electromagnetic stove automatic opening-→ evaporative cylinder diacolation solution solvents evaporations-→ Solvent evaporate gas through gas delivery pipe-→ 6. gas be sent into condenser solvent gas merging chamber-→ solvent gas and enter condensation Device spiral condensing tube be condensed into liquid-→ liquid into condenser condensing solvent collecting chamber-→ flow into condensing solvent recovery cylinder- → it is put into condensing solvent storage barrel-→ recycling or storage-→ 7. unlatching diacolation solution evaporative cylinder bottom valve-→ coarse extraction Medicine is put into the distilled water-→ that the storage barrel-heavy agitator addition of → heavy agitator-→ water of preparation water accounts for extraction medicine 60% and is slowly added to Extraction medicine, which quickly stirs-→ and stirs to load precipitation cylinder-→ and be put into 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation, to be completed Pour out supernatant-→ and obtain the thick finished medicines of compound bavin head red sage root anti-liver cancer and anti-s.Compound bavin head red sage root anti-liver cancer and anti-oral liquids finished medicines are prepared： After thick finished medicines are measured by volume, subtracted from oral liquid total capacity, residual volume amount, in 5: 5 ratio calculate honey with Distilled water adds capacity, and preservative is calculated by 0.1% dosage；It is standby that stainless steel cylindrical vessel is risen with 300-400, it is total by what is measured Extract medicine, honey, distilled water, preservative and add stainless steel cylindrical vessel, mixed, elder generation's stirring at low speed during stirring, no Disconnected regulation is to high-speed stirred, until stirring.Compound bavin head red sage root anti-liver cancer and anti-oral liquid filling sterilization packagings：Will stirring Uniform oral liquid finished product adds filling apparatus, carries out oral liquid bottling capping with 200 milliliters of volumetric flasks, obtains the compound bavin head reds sage root Anti-liver cancer and anti-oral liquid finished product；Bottled oral liquid finished product is preserved into sale through high-temperature sterilization, adhesive label, mounted box vanning, storage.It is multiple Square bavin head reds sage root anti-liver cancer and anti-oral liquid is taken：Oral 20 milliliters every time, 1 twice.

According to《Chinese book on Chinese herbal medicine》Record：The first root first for dicotyledon medicine Umbelliferae Bupleunim. L bavin of bavin, is radix bupleuri One kind, main product Sichuan Aba Tibetan Autonomous Prefecture, Mao Wen, Heishui County etc., it is grown in 2100-2700 rice endroit brush lands. Containing volatile oil, inside have：2- methyl-cyclopentanones, 3- heptanone, limonene, 3- Bi alkene, 2-amyl furan, carvacrol, dextrorotation Pueraria lobota Thread ketone, verbenone, fenchone, trans carveol, pulegone, neral, n-undecane, cumfrey, 5- methyl -5- base decane, 3- methyl dodecanes, n-tetradecane, α-cubebene, γ-cadinene, β-gurjunene, α - (king is ancient) (king bar) alkene, aromadendrene, cis cloves alkene, α-guaiene, α-and beta-elemene, γ muurolenes, n-pentadecane, Nu Teka Japan cypress ketone, ledol, farnesyl acetone；General glycoside containing radix bupleuri 1.83% again, wherein saikosaponin-a 0.30%, bavin Hu saponin c0.82%, Saikosaponin d 0.71% [11].With antitumaous effect, its main anticancer component is α-and beta-elemene, Saikosaponin d 0.71%；The red sage root is the root of the labiate red sage root and Salvia przewalskii Maxim.Containing in liposoluble constituent, category quinone, Ketone type structure has：Tanshinone I, II A, II B [1,2], V, VI [2], Cryptotanshinone [1], isotanshinone I, II [3], II B [4], different Cryptotanshinone [3], hydroxyl Tanshinone I I A, saivianic acid A acid [1], danshenxinkun A, B, C [1], D [6], the different pellet of dihydro Join ketone I [7], new Cryptotanshinone [4] removes the new Cryptotanshinone of hydroxyl [8], the 2- isopropyl-8- methylphenanthrenes that code name is Ro-090680- 3,4- diketone [9], remove first tanshinone, Tanshindiol A, B, C [10], miltionone [11], 1- hydrogen miltionones, 1- hydrogen tanshinones II A [12], 1- hydrogen are red for different Cryptotanshinone [13], 3 Alpha-hydroxy Tanshinone I I A [10], 1,2- dihydro red sage root quinone [14], aldehyde radical Join ketone, methylene dihydrotanshinone, 7 beta-hydroxy -8,13- abietadiene -11,12- diketone, 1,2,5,6- tetrahydrochysene Tanshinone I, 4- Asias First miltionone [15], tanshinlactone [17], dihydro tanshinlactone [18], red sage root Spiroketals lactone, table red sage root Spiroketals lactone [19], red sage root Spiroketals lactone II [18], are exactly the hidden spirolactone of the red sage root [20], sageone [22].Red sage root tropolone [23] etc.；Category other types structure has：Salvia japonica oxide [22], ferruginol [12], carnosol 14 drop], cryptojaponol [15] etc..Water miscible phenol acid compound has：Salvianic acidA, B, C, Salvianic acidA are also known as danshensu, its structure be D (+)-β- (3,4- dihydroxy phenyl) lactic acid, lithospermic acid B are to be condensed what is formed by the danshensu of 3 molecules and the caffeic acid of 1 molecule, are exactly red Join phenolic acid B；Red sage root acid C is the condensation product [24,25] of 2 molecule danshensus；Salviol acid A, B, C, D, E, G [26-29]；Rosemary Acid, methyl rosmarinate [27], alkannic acid mono methyl ester, alkannic acid dimethyl ester, alkannic acid ethyl ester [30], alkannic acid B [31] are former several Tea aldehyde, caffeic acid [27], isoferulic acid [30] etc..Also glucoside containing radix scutellariae [32], different imperatorin [13], ursolic acid, β-paddy steroid Alcohol, Daucosterol [35], 5- (3- hydroxypropyls) -7- methoxyl groups -2- (3- methoxyl group -4- hydroxyphenyls) -3- benzofuran formaldehyde [33], for by sapogenin [1], stigmasterol [7] etc..Get Tanshinone I II A, II B in rhizome, Cryptotanshinone, danshenxinkun B, Dihydrotanshinone I, methylene red sage root quinone [34].Tanshinone I, Cryptotanshinone, isoferulic acid, former catechu are obtained from danshen injections Acid, butanedioic acid, Rosmarinic acid, salviol acid A [35].S.Przewalskii Maxim grass roots is containing Tanshinone I, II A [36], II B [37], hidden pellet Ginseng ketone, hydroxyl tanshinone, methyl tanshinonate [36], radix salviae miltiorrhizae ester A, B, methylene red sage root quinone, 1,2- dihydro red sage root ester [38], together Pier tartaric acid, radix salviae miltiorrhizae terpene acid A, B [39], the new ester B of the red sage root, tanshinlactone, remove first tanshinone, dihydrotanshinone I [40], radix salviae miltiorrhizae Terpene ether [37], the right sour A [41] of radix salviae miltiorrhizae furan, radix salviae miltiorrhizae anthraquinone, 1,5- hydroxy-3-methyl anthraquinone [42], cupreol [36].Half Summer is the stem tuber of the Araeceae tuber of pinellia.Containing volatile oil, it is 3- acetylaminohydroxyphenylarsonic acid 5- methyl isoxazoles to include principal component, butylethylene Base ether, 3- methyl eicosanes, also hexadeeene diacid(hexadecendioic acid), 2- chloracrylic acids methyl esters, anethole, benzaldehyde, 1,5-PD, 2- Methylpyrazine, citral, 1- octenes, β elemenes, methyln nonyl ketone, 9- heptadecanols, ethyl palmitate, valeraldehyde oxime etc. more than 60 Kind composition.Also contain sanedrine, choline, cupreol, Daucosterol, alcapton, protocatechualdehyde, the peppery ketenes of ginger, baicalin, Baicalein, the peppery alcohol of ginger, 1,2,3,4,6- five-O- galloyl glucoses, the carbon -7,10- bis- of 12,13- epoxy -9- hydroxyls 19 Olefin(e) acid and radical derivative etc..Contain again with α-and beta-aminobutyric acid, aspartic acid for principal component amino acid and with calcium, iron, aluminium, Inorganic elements based on magnesium, manganese, thallium, phosphorus etc..Separately contain polysaccharide, amylose, pinellin (being a kind of phytolectin) and pancreas egg White enzyme inhibitor etc.；Its main anticancer component of the tuber of pinellia is β elemenes and pinellin；Radix scutellariae is labiate radix scutellariae, Yunnan Huang The root of a kind of reed mentioned in ancient books, Sutellaria viscidula and Lijing radix scutellariae.Contain flavone compound：Baicalein, neobaicalein, i.e. skullcapflavone II, radix scutellariae Glucoside, wogonin, wogonoside [1], oroxylin A, 7- methoxyl group baicalein [2], skullcapflavone I [3,4], dihydro Oroxylum indicum Plain A, Chrysin, 2,5,8- trihydroxy -7- methoxy flavones, the hydroxyl of 2,5,8- trihydroxy -6,7- dimethoxy flavone 4,5,7- tri- Base -6- methoxy flavanones [5], 7- penta hydroxy group flavanones wogonin -5- β-D-Glucose glucoside, Chrysin；-6-C-α-L- Arabic glucoside, Chrysin -6-C- α-L-arabinose glucoside -8-C- β-D-Glucose glucoside, (2S) -2,5,6,7- tetrahydroxy flavane Ketone, 5,7,2,6- kaempferols, 5,8- dihydroxy -6,7- dimethoxy flavones, 5,7,4- trihydroxy -8- methoxy flavones, Oroxylin A-7-O- glucuronides, 5,7,2- trihydroxy methoxy flavones, 8- trimethoxy flavones, 5- gate of a lane bases -7,8- Dimethoxy flavone, Norwogonin, dihydro baicalein, 5,7,2- trihydroxyflavones, 5,7,2- trihydroxy -8,6- dimethoxies Base flavones, 5- tetrahydroxy -8.6- dimethoxy flavones are viscidulin III5,25- trihydroxy trimethoxy flavones, radix scutellariae Element -7-O- β-D- glucopyanosides；5,7,2- trihydroxy -8- methoxy flavones are tenaxin II, 8- dimethoxy flavones (5,2,6- trihydroxies -6-methoxy-2-phenyl-4H-chromen-4-one, 3- kaempferols, 5,7,2,3- tetra- great base flavones, 6- pentahydroxyflavones are adhesive hair Baicalein I, (2S) -7,2,6- trihydroxy -5- methoxy flavanones, 2,6,2,4- tetrahydroxy -6- methoxyl group chalcones, the hydroxyls of 5- tetra- Base flavones, left-handed eriodictyol, Sculellaria barbata kind element and viscidulin III-2-O- β-D- glucopyanosides etc..In addition also containing β- Sitosterol, campesterol and stigmasterol.2. Yunnan scutellariae,radix baicalein containing river rising in Ningxia and flowing into central Shaanxi, baicalein, baicalin, wogonoside, 5,7,2- tri- Hydroxyl -6-methoxy-2-phenyl-4H-chromen-4-one [15,16], (2S) -5,7,8- trihydroxy flavanones, (2S) -2,5,6,7- tetrahydroxy flavane radix scutellariaes Element, oroxylin A, scuteamoenoside, 7- tetrahydroxy flavanones, scuteamoenin, (2R, 3R) -3,5,7- trihydroxy flavanones, Skullcapflavone II, 7- pentahydroxyflavone, Chrysin, cupreol [16].3. Sutellaria viscidula root contains baicalin, wogonoside [18, 19], baicalein, wogonin, oroxylin A, neobaicalein, 5,2- dihydroxy dimethoxy flavones are skullcapflavone I etc., its Main anticancer component is skullcapflavone II and radix scutellariae ether extract；Glycyrrhiza glabra is legume glycyrrhiza glabra root and rhizome, and category is sweet One kind of grass, it is separable to obtain glycyrrhizic acid, outside 18- β enoxolones containing glycyrrhizin, also obtain a variety of triterpenes Compound：18 Alpha-hydroxy enoxolones, 24- hydroxyl enoxolones, 24- hydroxyl -11- deoxyglycyrrhetinic acids, 11- deoxidation radix glycyrrhizaes time Acid, 3 beta-hydroxy olives -11,13 (18)-diene -30- acid glycyrrhetols, glycyrrhiza glabra ester, different glycyrrhiza glabra examine ester, deoxidation Glycyrrhiza glabra lactone, the different glycyrrhiza glabra lactone of 21 Alpha-hydroxies, liquoric acid etc..Contain flavone component again：Glycyrrhiza glabra glucoside is Liquiritin, glycyrrhiza glabra glucoside member is liquiritigenin, and different glycyrrhiza glabra glucoside is isoliquiritin, and different glycyrrhiza glabra glucoside member is sweet Careless glucoside member, neoliquriitin, close isoliquiritin, Isoliquiritigenin -4 '-celery sugar glycoside, Isoliquiritigenin -4- celery sugar glucose Glucoside, glabranin, glycyrrhiza glabra alcohol, glycyrrhiza glabra are fixed, glycyrrhiza glabra ketone, glycyrrhiza glabra element, and 7,2 '-dihydroxy -3 ', 4 ' - Methylene-dioxy isoflavones, 7- acetoxyl group -2- methyl isoflavones, 7- methoxyl group -2- methyl isoflavones, 7- hydroxy-2-methyls Isoflavones, raw loose flavanones, prunetin, formoononetin etc..Coumarin containing glycyrrhiza glabra and water-soluble polysaccharide and pectin again.Light Isolated 18 β of aerial part-enoxolone of fruit radix glycyrrhizae, 18 α-enoxolone are biosone, and a variety of flavonoids Compound：Quercetin, Isoquercitrin, the double glycosides of Quercetin -3-, Kaempferol, astragalin, saponaretin, liquiritigenin are different Liquiritigenin, Genkwanin, Kaempferol-bis- grapes glucoside etc..Separately contain polysaccharide 9.7%, wherein water-soluble polysaccharide 1.6%；Its is main Anticancer component is glycyrrhizic acid and enoxolone；The honey that honey is made by the close honeybee of Apidae animal China or apis mellifera.Contain There is the glucide led in honeycomb, master contains glucose, fructose；Other also contain sucrose, dextrin, organic acid, protein, volatilization Oil, wax, pollen grain, vitamin B1, B2, B6, C, K, H, amylase, turn people's enzyme, peroxidase, esterase, growth stimulant, acetyl Choline, nicotinic acid, pantothenic acid, carrotene, inorganic elements calcium, sulphur, phosphorus, magnesium, potassium, sodium, iodine etc..

The beneficial effects of the invention are as follows：Above-mentioned 6 kinds of Chinese medicine prescriptions, bavin head have antitumaous effect, its main anticancer component For α-and beta-elemene, Saikosaponin d 0.71%, have the function that to strengthen immunization, hepatoprotective effect, anti peroxidation of lipid, Antipathogen effect, antiinflammatory action, sedation, antipyretic effect, anticonvulsant action etc.；The red sage root has antitumor, the anti-heart Muscle infarction, anti-arrhythmia, Hemorrhagic shock, treatment cardiovascular and cerebrovascular disease, enhancing immunologic function, antiviral, antibacterial, anti-inflammatory etc. are made With；Its main anticancer component of the tuber of pinellia is β elemenes and pinellin, has anticancer, antifertility, reducing blood lipid, protect liver and treatment hat Worry etc. acts on, and radix scutellariae has antitumaous effect, effect for reducing blood fat, liver protection, cholagogic, antioxidation, platelet aggregation-against and resisted Solidifying, anti-inflammatory antiallergic action, antivirus action, antifungic action, antibacterial action etc., its main anticancer component is skullcapflavone II With radix scutellariae ether extract；Make with antitumaous effect, effect for reducing fat and the effect of anti-atherogenic stalkization, antiarrhythmic effect, liver protection With, to body's immunity adjustment effect, antivirus action, refrigeration function, sedation, analgesia, spasmolysis, anti-inflammatory make With, eliminating phlegm and relieving cough effect, antiulcer action etc.；Its main anticancer component of radix glycyrrhizae is glycyrrhizic acid and enoxolone；Honey has anti- Fatty liver effect, the composition that can improve blood, promote heart and brain and vascular function；There is protective effect to liver, liver cell can be promoted Regeneration；It can rapidly regain one's strength of body, dispelling fatigue, build up one's resistance to disease；The also effect of sterilizing；Moderate can be treated Skin damage, particularly scald；Sleep can be improved；Can also relax bowel, 6 kinds of tcm and herbal slices of the above have anticancer, Reducing blood lipid, hypoglycemic, hypotensive, anti-fatty liver, the anti-ageing effect of waiting for a long time；Effect is complementary, and effect is extensive, is often drunk by the course for the treatment of, then adds Upper necessary physical training, psychological quality is adjusted, one surely plays anticancer, health-care effect, mitigates patient mental's burden, improves and suffers from Person's quality of life.

Embodiment

Specific embodiment：

1st, formulating compound bavin head red sage root anti-liver cancer and anti-oral liquid prescriptions is：Bavin is first 35 grams, 30 grams of the red sage root, 20 grams of the tuber of pinellia, radix scutellariae 20 grams, 5 grams of glycyrrhiza glabra, honey is equal with distillation water consumption, by 5: 5 volume measurements, preservative dosage 0.1%.

2nd, it is 1000 bottles to determine this batch compound bavin head red sage root anti-liver cancer and anti-oral liquids output, per bottled 200 milliliters, is needed altogether Oral liquid total amount is prepared as 200 liters.

3rd, the tcm and herbal slice total amount as needed for this batch compound bavin head reds sage root anti-liver cancer and anti-oral liquid output and recipe calculation For 550 kilograms, calculating 5 kinds of tcm and herbal slice amount of purchases by formula rate is respectively：Bavin is first 175 kilograms, 150 kilograms of the red sage root, The ratio of tuber of pinellia double centner, radix scutellariae double centner, 25 kilograms of glycyrrhiza glabra, honey and distilled water be 5: 5, wait Chinese medicine effectively into Metering is purchased after the completion of dividing extraction；Preservative dosage is 0.1%, and 75% alcohol solvent purchases 1000 liters, is recycled.

4th, compound bavin head reds sage root anti-liver cancer and anti-oral liquid tcm and herbal slice is processed：Every kind of tcm and herbal slice is carried out selected and dried in the air Shine, after being sufficiently mixed uniformly, first crushed with 6 millimeters of particle diameter pulverizers, then it is standby with 3 millimeters of particle diameter pulverizers crushing.

5th, compound bavin head reds sage root anti-liver cancer and anti-oral liquid tcm and herbal slice extracts active ingredients：Ethanol extract from water precipitation is taken to carry out, " cylinder is electronic follows for medicinal herb componentses suit for the patent of invention (July 3 2017 applying date) designed using the applicant, applied Ring automatic fitration percolating extractor " carries out seepage pressure effects；The device is by percolating extractor support, suit cylinder diacolation dress Put, electric pump circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent steam Send out separator, the part of diacolation solvent condensate recycling device seven composition；The percolating extractor operation technological process is：1. close Diacolation solution control valve-→ opens charging closure-→ meter feedstock loading inner cylinder-→ layering loading actual situation, and uniformly-→ adds Diacolation solvent, which is drenched in circular groove-→ circular groove, to be slowly added to diacolation solvent-→ solvent and uniformly drenches push down circular groove into raw material-→ and not float Rise-→ solvent add to no longer drench into 5 centimetres away from circular groove bottom only-→ by circular hole in the middle part of closure rotate to drench into circular groove inner edge-→ Opening diacolation solution circulation pump-→ regulation diacolation solution circulating valve does not make diacolation solution overflow only-→ closing diacolation solution circulation Pump-→ closes charging closure and penetrates 36 hours-→ unlatching diacolation solution circulation pump circulatory displacements of screw tightening-→ standing diacolation 36 hours-→ close diacolation solution circulation pump-→ open diacolation solution control valve-→ diacolation solution through internal barrel bottom screen pack from Dynamic filtering-→ through diacolation solution control valve ,-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ filtered fluid and flowed into Open charging closure-→ and open diacolation solution circulation pump-→ and determine internal barrel bottom screen pack in diacolation solution evaporative cylinder bottom-→ Whether filtering, which terminates ,-→ is 2. terminated filtering and closes diacolation solution control valve-→ and add new diacolation solvent-→ and carry out secondary cycle to ooze Filter after the completion of extraction (operating process is identical with first time)-→ secondary cycle seepage pressure effects-→ open diacolation solution control valve-→ Secondary diacolation solution is through the screen pack automatic fitration of internal barrel bottom-→ flow into the top screen pack natural filtration of diacolation solution evaporative cylinder- → secondary diacolation solution flows into diacolation solution evaporative cylinder bottom-→ and-→ is mixed with first time diacolation solution 3. taking-up inner cylinder is poured out Dregs of a decoction cleaning-→ inner cylinder is reentered into outer barrel-→ and closed under diacolation solution control valve-→ meter feedstock loading inner cylinder-→ entrance Secondary seepage pressure effects program-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to hot water Case, hot water storgae, condenser add water-→ to open electromagnetic stove to boiler heating-→ unlatching hot water circulating pump-→ boiler and hot water Groove hot water starts the cycle over-→, and 5. opening automatic temperature control instrument-→ to diacolation solution evaporative cylinder heating-→ adjusts temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature be down to 80 DEG C of electromagnetic stoves from Dynamic unlatchings-→ evaporative cylinder diacolation solution solvent evaporation-→ solvent evaporation gas through gas delivery pipe-→ 6. gas feeding condenser Solvent gas merging chamber-→ solvent gas into condenser spiral condensing tube be condensed into liquid-→ liquid into condenser it is cold Solidifying solvent collecting chamber-→ flow into condensing solvent recovery cylinder-→ be put into condensing solvent storage barrel-→ recycle or storage-→ 7. Open diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine and be put into storage barrel-→ heavy agitator of the heavy agitator-→ water of preparation water Add account for extraction medicine 60% distilled water-→ be slowly added to extract medicine quickly stir-→ stir load precipitation cylinder-→ be put into 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion pour out supernatant-→ and obtain the thick finished medicines of compound bavin head red sage root anti-liver cancer and anti-s.

6th, compound bavin head reds sage root anti-liver cancer and anti-oral liquid finished medicines are prepared：It is total from oral liquid after thick finished medicines are measured by volume Subtracted in 200 liters of capacity, residual volume amount, calculate honey in 5: 5 ratio adds capacity with distilled water, and preservative is pressed 0.1% dosage calculates；It is standby that stainless steel cylindrical vessel, thick finished medicines, honey, distilled water, the anti-corrosion that will be measured are risen with 300-400 Agent adds stainless steel cylindrical vessel, is mixed, elder generation's stirring at low speed, constantly regulate to high-speed stirred during stirring, until filling Divide and stir.

7th, compound bavin head reds sage root anti-liver cancer and anti-oral liquid filling sterilization packaging：The oral liquid finished product to stir is added filling Device, the bottling capping of bavin head red sage root anti-liver cancer and anti-s oral liquid is carried out with 200 milliliters of volumetric flasks；Bavin head red sage root anti-liver cancer and anti-oral liquids into Product；Bottled bavin head reds sage root anti-liver cancer and anti-oral liquid finished product is preserved into sale through high-temperature sterilization, adhesive label, mounted box vanning, storage.

8th, compound bavin head reds sage root anti-liver cancer and anti-oral liquid is taken：Oral 20 milliliters every time, 1 twice.

Claims (7)

1. compound bavin head red sage root anti-liver cancer and anti-oral liquid prescriptions, it is characterized in that：Bavin is first 35 grams, 30 grams of the red sage root, 20 grams of the tuber of pinellia, radix scutellariae 20 Gram, 5 grams of glycyrrhiza glabra,；Honey and distillation water consumption, by 5: 5 volume measurements, preservative dosage 0.1%.

2. compound bavin head red sage root anti-liver cancer and anti-oral liquid materials procurements；It is characterized in that：First determine compound bavin head red sage root anti-liver cancer and anti-mouths Liquid output is taken, then goes out by recipe calculation the amount of purchase of every kind of tcm and herbal slice and is purchased, the various tcm and herbal slices of buying Have to comply with the quality index and specification standards of every kind of tcm and herbal slice, without go mouldy, it is no disease and pests harm, free from admixture, pollution-free；75% It is 2: 1 that etoh solvent, which is purchased with tcm and herbal slice total amount buying ratio,.

3. compound bavin head red sage root anti-liver cancer and anti-oral liquids raw material are processed：It is characterized in that；In addition to honey, distilled water, preservative, to every Kind of tcm and herbal slice is carried out selected and dried, and after being sufficiently mixed uniformly, is first crushed with 6 millimeters of particle diameter pulverizers, then with 3 millimeter particles Footpath pulverizer crushes standby.

4. compound bavin head red sage root anti-liver cancer and anti-oral liquid tcm and herbal slice extracts active ingredients：It is characterized in that：Take ethanol extract from water precipitation Carry out, patent of invention (July 3 2017 applying date) " the medicinal herb componentses suit cylinder electricity designed using the applicant, applied Dynamic circulation automatic fitration percolating extractor " carries out seepage pressure effects；The device is by percolating extractor support, suit cylinder diacolation Device, electric pump circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent Evaporating separation device, the part of diacolation solvent condensate recycling device seven composition；The percolating extractor operation technological process is：1. close Close diacolation solution control valve-→ open charging closure-→ meter feedstock load inner cylinder-→ layering load actual situation uniform-→ plus Enter diacolation solvent and drench in circular groove-→ circular groove to be slowly added to diacolation solvent-→ solvent and uniformly drench into raw material-→ that pushing down circular groove should not Float-→ solvent add to no longer drench into 5 centimetres away from circular groove bottom only-→ by circular hole in the middle part of closure rotate to drench into circular groove inner edge- → unlatching diacolation solution circulation pump-→ regulation diacolation solution circulating valve does not make diacolation solution spilling, and only-→ closing diacolation solution follows Ring pump-→, which closes charging closure and penetrates screw tightening-→ and stand diacolation 36 hours-→ and open diacolation solution circulation pump and circulate, to be oozed - → closing diacolation solution circulation pump-→ of filtering 36 hours opens diacolation solution control valve-→ diacolation solution through internal barrel bottom screen pack Automatic fitration-→ through diacolation solution control valve-→ diacolation solution inflow evaporative cylinder top screen pack natural filtration-→ filtering liquid stream Enter diacolation solution evaporative cylinder bottom-→ opening charging closure-→ unlatching diacolation solution circulation pump-→ and determine that internal barrel bottom is filtered Whether net, which filters, which is terminated ,-→ 2. terminates filtering closing diacolation solution control valve-→ addition new diacolation solvent-→ progress secondary cycle After the completion of seepage pressure effects (operating process is identical with first time)-→ secondary cycle seepage pressure effects-→ open diacolation solution control valve- Through the screen pack automatic fitration of internal barrel bottom ,-→ flows into diacolation solution evaporative cylinder top screen pack nature mistake to → secondary diacolation solution Filter-→ secondary diacolation solution flows into diacolation solution evaporative cylinder bottom-→ and-→ is mixed with first time diacolation solution 3. taking-up inner cylinder falls Go out dregs of a decoction cleaning-→ inner cylinder and be reentered into outer barrel-→ closing diacolation solution control valve-→ meter feedstock loading inner cylinder-→ entrance Next seepage pressure effects program-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to hot water Case, hot water storgae, condenser add water-→ to open electromagnetic stove to boiler heating-→ unlatching hot water circulating pump-→ boiler and hot water Groove hot water starts the cycle over-→, and 5. opening automatic temperature control instrument-→ to diacolation solution evaporative cylinder heating-→ adjusts temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature be down to 80 DEG C of electromagnetic stoves from Dynamic unlatchings-→ evaporative cylinder diacolation solution solvent evaporation-→ solvent evaporation gas through gas delivery pipe-→ 6. gas feeding condenser Solvent gas merging chamber-→ solvent gas into condenser spiral condensing tube be condensed into liquid-→ liquid into condenser it is cold Solidifying solvent collecting chamber-→ flow into condensing solvent recovery cylinder-→ be put into condensing solvent storage barrel-→ recycle or storage-→ 7. Open diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine and be put into storage barrel-→ heavy agitator of the heavy agitator-→ water of preparation water Add account for extraction medicine 60% distilled water-→ be slowly added to extract medicine quickly stir-→ stir load precipitation cylinder-→ be put into 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion pour out supernatant-→ and obtain the extraction of compound bavin head red sage root anti-liver cancer and anti-s finished product Medicine.

5. compound bavin head red sage root anti-liver cancer and anti-oral liquids finished medicines are prepared；It is characterized in that：After total extraction medicine is measured by volume, from oral Subtracted in 200 liters of liquid total measurement (volume) amount, residual volume amount, calculate honey and distillation water capacity in 5: 5 ratio, preservative is pressed 0.1% dosage calculates；It is standby that stainless steel cylindrical vessel is risen with 300-400, by the total extraction medicine measured, honey, distilled water, anti-corrosion Agent adds stainless steel cylindrical vessel, is mixed, elder generation's stirring at low speed, constantly regulate to high-speed stirred during stirring, until filling Divide and stir.

6. compound bavin head red sage root anti-liver cancer and anti-oral liquid filling sterilization packagings；It is characterized in that：The oral liquid finished product to stir is added Enter filling apparatus, oral liquid bottling capping is carried out with 200 milliliters of volumetric flasks；Obtain fat reducing and weight reducing oral liquor finished product；Will be bottled oral Liquid finished product preserves sale through high-temperature sterilization, adhesive label, mounted box vanning, storage.

7. compound bavin head red sage root anti-liver cancer and anti-oral liquids are taken；It is characterized in that：Oral 20 milliliters every time, 1 twice.