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CN107260977A - A kind of brain tonic and intelligence development oral liquid and its preparation technology - Google Patents

A kind of brain tonic and intelligence development oral liquid and its preparation technology Download PDF

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Publication number
CN107260977A
CN107260977A CN201710651250.5A CN201710651250A CN107260977A CN 107260977 A CN107260977 A CN 107260977A CN 201710651250 A CN201710651250 A CN 201710651250A CN 107260977 A CN107260977 A CN 107260977A
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diacolation
oral liquid
diacolation solution
solvent
intelligence development
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冯敏杰
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

A kind of brain tonic and intelligence development oral liquid of the present invention and its preparation technology, prepare canned, filling oral liquid sterilizing, label stickup and packaging multiple working procedure by the formulation of brain tonic and intelligence development oral liquid prescription, materials procurement, raw material processing, raw material tcm and herbal slice extracts active ingredients, oral liquid finished product and machine;Brain tonic and intelligence development oral liquid prescription is formulated:8 kinds of ganoderma lucidum 10,10 grams of Radix Codonopsis etc., honey and distillation water consumption, by 5: 5 volume measurements, preservative consumption 0.1%, the buying ratio of 75% alcohol solvent and tcm and herbal slice total amount is 2: 1;Raw material tcm and herbal slice extracts active ingredients, the patent of invention (July 3 2017 applying date) " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " designed using the applicant, applied carries out seepage pressure effects, extract solution adds auxiliary material to be mixed evenly, carried out with 200 milliliters of volume oral liquid bottles it is canned, pack, it is oral 20 milliliters every time, twice a day.

Description

A kind of brain tonic and intelligence development oral liquid and its preparation technology
Technical field
A kind of brain tonic and intelligence development oral liquid of the present invention and its preparation technology are related to herbal health care Product processing field, especially relate to And a kind of brain tonic and intelligence development oral liquid and its preparation technology.
Background technology
With the fast development for writing China economy, national income is continuously increased, and numerous residents are particularly middle and high income and old The hope that year people, sub-health population pursue healthy, prevention disease, resistance aging, brain tonic and intelligence development, promotes longevity increasingly increases It is long, be it is healthy spare no high price, in order to meet demand of the numerous residents to above-mentioned hope, present invention selection ganoderma lucidum, Radix Codonopsis, what 8 kinds of tcm and herbal slices such as the tuber of multiflower knotweed, rhizoma Gastrodiae, the Radix Astragali, the fruit of Chinese wolfberry, the fruit of Chinese magnoliavine, Poria cocos, are fabricated to a kind of brain tonic and intelligence development oral liquid, effect Fruit significantly, is had complementary functions, and effect is extensive, with brain tonic and intelligence development, disease-resistant salubrity, and enhancing is immune, and anti-aging is antitumor, normal by the course for the treatment of Drink, along with necessary physical training, adjusts psychological quality, and brain tonic and intelligence development, prevention disease can be played surely, health care of body water is improved Flat purpose.
The content of the invention
The purpose of the present invention is, from 8 kinds of ganoderma lucidum, Radix Codonopsis, the fleece-flower root, rhizoma Gastrodiae, the Radix Astragali, the fruit of Chinese wolfberry, the fruit of Chinese magnoliavine, Poria cocos etc. Tcm and herbal slice, reasonable compatibility, retrofit produces the oral liquid product of high-quality brain tonic and intelligence development, consumer is played can The health-care effect leaned on.
To achieve these goals, the technical solution adopted by the present invention is:A kind of brain tonic and intelligence development oral liquid and its preparation work Skill, is carried by the formulation of brain tonic and intelligence development oral liquid prescription, materials procurement, raw material processing, raw material tcm and herbal slice active ingredient Take, oral liquid finished product is prepared canned, filling oral liquid sterilizing, label stickup and packaging multiple working procedure and machined;Brain tonic and intelligence development Oral liquid prescription is formulated:10 grams of ganoderma lucidum, 10 grams of Radix Codonopsis, 10 grams of the fleece-flower root, 10 grams of rhizoma Gastrodiae, 10 grams of the Radix Astragali, 10 grams of the fruit of Chinese wolfberry, the five tastes Sub 10 grams, 10 grams of Poria cocos, honey and distillation water consumption, by 5: 5 volume measurements, preservative consumption 0.1%, 75% alcohol solvent with The ratio of tcm and herbal slice total amount is 2: 1;Materials procurement:First determine brain tonic and intelligence development oral liquid this batch produce total bottle number, it is every Bottle capacity, production total capacity, every bottle take number of days, take total number of days, then by recipe calculation go out 8 kinds of tcm and herbal slices need daily use Amount, graded kind is purchased, and the various tcm and herbal slices of buying have to comply with the quality index and specification of every kind of tcm and herbal slice Standard, without going mouldy, no disease and pests harm, free from admixture, pollution-free;75% etoh solvent is purchased is with tcm and herbal slice total amount buying ratio 2∶1;Raw material are processed:In addition to honey, distilled water, preservative, every kind of tcm and herbal slice is carried out selected and dried, is sufficiently mixed After uniform, first crushed with 6 millimeters of particle diameter pulverizers, then crush standby with 3 millimeters of particle diameter pulverizers;Raw material tcm and herbal slice has Constituents extraction is imitated, takes ethanol extract from water precipitation to carry out, patent of invention (in the July, 2017 applying date designed using the applicant, applied 3 days) " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " progress seepage pressure effects;The device is by diacolation It is extraction element support, suit cylinder percolating device, electric pump circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled Hot water circulating heating device, diacolation solvent evaporating separation device, the part of diacolation solvent condensate recycling device seven composition;The diacolation is carried The plant operator skill flow is taken to be:1. diacolation solution control valve-→ is closed to open in charging closure-→ meter feedstock loading Cylinder-→ layering, which is fitted into uniform-→ addition diacolation solvent of actual situation, drenches diacolation solvent-→ solvent is slowly added in circular groove-→ circular groove It is uniform drench into raw material-→ push down circular groove should not float-→ solvent add to no longer drench into 5 centimetres away from circular groove bottom only-→ by closure Middle part circular hole, which is rotated to drenching into circular groove inner edge-→ and open diacolation solution circulation pump-→ regulation diacolation solution circulating valve, does not make diacolation Solution, which overflows to stop-→ close diacolation solution circulation pump-→ and close charging closure, to be penetrated screw tightening-→ to stand diacolation 36 small When-→ open diacolation solution circulation pump circulatory displacement 36 hours-→ close diacolation solution circulation pump-→ and open the control of diacolation solution Valve-→ diacolation solution through the screen pack automatic fitration of internal barrel bottom-→ through diacolation solution control valve-→ diacolation solution flow into evaporative cylinder Top screen pack natural filtration-→ filtered fluid flows into diacolation solution evaporative cylinder bottom-→ and opens charging closure-→ unlatching diacolation Solution circulation pump-→ determines whether internal barrel bottom screen pack filters terminate-→ 2. terminate filtering close diacolation solution control valve-→ New diacolation solvent-→ is added to carry out secondary cycle seepage pressure effects (operating process is identical with first time)-→ secondary cycle diacolation and carry - → opens diacolation solution control valve-→ secondary diacolation solution through the screen pack automatic fitration of internal barrel bottom ooze by-→ inflow after the completion of taking Solution evaporative cylinder top screen pack natural filtration-→ secondary diacolation solution of filtering flow into diacolation solution evaporative cylinder bottom-→ with first - → 3. taking-up inner cylinder pours out dregs of a decoction cleaning-→ inner cylinder and is reentered into solution control of outer barrel-→ closing diacolation for secondary diacolation solution mixing Valve-→ meter feedstock loads inner cylinder-→ and enters next seepage pressure effects program-→ secondary diacolation solution evaporative cylinder self-filtering net mistake Filter terminates-→ 4. connect water source-→ to boiler, hot water storgae, condenser add water-→ open electromagnetic stove to boiler heating-→ Unlatching hot water circulating pump-→ boiler starts the cycle over-→ with hot water storgae hot water and 5. opened certainly to diacolation solution evaporative cylinder heating-→ Dynamic temperature controller-→ regulation temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature rises to 90 DEG C of electromagnetic stoves and closed automatically Close-→ hot water storgae water temperature is down to 80 DEG C of electromagnetic stove automatic opening-→ evaporative cylinder diacolation solution solvent evaporation-→ solvents evaporation gases Through gas delivery pipe-→ 6. gas feeding solvent gas merging chamber-→ solvent gas into spiral condensing tube be condensed into liquid- → liquid enters condensing solvent collecting chamber-→ inflow condensing solvent recovery cylinder-→ and is put into condensing solvent storage barrel-→ recycling Or storage-→ 7. open diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine be put into storage barrel-→ preparation water sink agitator- → water sinks agitator and adds to account for the distilled water-→ for extracting medicine 60% and be slowly added to extract medicine and quickly stir-→ and stir loading Precipitation cylinder-→ is put into 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion pours out supernatant-→ and obtains brain tonic and intelligence development finished product and carry Get it filled.Brain tonic and intelligence development oral liquid finished medicines are prepared:Finished product is extracted after medicine measures by volume, is subtracted from 200 liters of oral liquid total capacity Go, residual volume amount, honey and distillation water capacity are calculated in 5: 5 ratio, preservative is calculated by 0.1% consumption;It is standby with 300-400 rises stainless steel cylindrical vessel, and the total extraction medicine measured, lactose, distilled water, preservative are added into stainless steel cylinder holds Device, is mixed, first stirring at low speed during stirring, and constantly regulate is to high-speed stirred, until stirring.Brain tonic and intelligence development Oral liquid filling sterilization packaging:The oral liquid finished product stirred is added into filling apparatus, carried out orally with 200 milliliters of volumetric flasks Liquid bottling capping, obtains brain tonic and intelligence development oral liquid finished product;By bottled oral liquid finished product through high-temperature sterilization, adhesive label, mounted box is cased, Storage preserves sale.Brain tonic and intelligence development oral liquid is taken:Oral 20 milliliters every time, 1 twice.
According to《Chinese book on Chinese herbal medicine》Record:The beneficial effects of the invention are as follows:Above-mentioned 8 kinds of Chinese medicine prescriptions;Ganoderma lucidum is bracket fungus The fructification of section fungi ganoderma lucidum, purple sesame etc..Contain a variety of polysaccharide effective constituents:A kind of water-soluble polysaccharide for having antitumor activity GL-1, is that, by glucose, xylose and arabinose are constituted by mole ratio 18.8: 1.5: 1.0, and relative molecular mass is 40000.Another to have GL-B A, B, the C for having hypoglycemic activity, GL-B A peptide core content is less than 2.6%, saccharide portion system It is made up of rhamnose, galactolipin and glucose by mole ratio 0.4: 1.0: 0.7;GL-B B Hes containing glucan 55.1% Peptide core 44.4%, its amino acid, which is constituted, is:Glycine 13.6%, aspartic acid 12.3%, alanine 10.9%, glutamic acid 10.3%, threonine 9.4%, serine 9.1%, valine 6.6%, tyrosinase 15 .5%, leucine 4.1%, proline 4.0% and other a small amount of amino acid;Containing polysaccharide 72.5%, (wherein glucose is 69.6% to GL-B C, and 2.9%) galactolipin is And peptide core 25.5%, its amino acid, which is constituted, is:Glycine 12.7%, alanine 12.5%, serine 11.5%, threonine 11.1%, aspartic acid 9.2%, glutamic acid 7.6%, valine 6.6%, tyrosinase 15 .5%, proline 5.2%, leucine 4.0% and other a small amount of amino acid.It is also a kind of to have promotion nucleic acid protein anabolic action, improve the polysaccharide of hematopoiesis function BN3C, it is integral therefrom to isolate 4 kinds of polysaccharide, confirmed:BN3C1 is glucan;BN3C3 is by glucose, arabinose group Into peptide polysaccharide, the mole ratio of glucose and arabinose is 4: 1, and the content of peptide is 5.4%, by cystine, leucine, junket Propylhomoserin, alanine, phenylalanine, valine, glutamic acid, γ-aminobutyric acid and micro arginine, lysine, methionine, group Propylhomoserin is constituted.GL-B, with hypoglycemic, hypocholesterolemic and antitumor action.Radix Codonopsis is often joined for Campanulaceae, element Flower Radix Codonopsis, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, the root of C. canescens.Containing polysaccharide [2], taraxerol, acetic acid Pu is public English sterol ester, freidelin, stigmasterol [9], Syringin [20], tangshenoside I, (E) -2- vinyls-β-sophoroside, (E) -2- alkene Base-α-L- mutter aralino (1 → 6)-β-D- glucopyanosides [, base-β-gentiobioside, base-β-sophoroside, Glucopyanoside, often ginseng lactone is atractylenoide Ⅲ, codopiloic acid;And aspartic acid, threonine, serine, sweet ammonia Acid, glutamic acid, alanine, cystine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, lysine, The amino such as histidine, thick propylhomoserin, proline [18] and iron, copper, cobalt, MnZn, nickel, arsenic, alum, molybdenum, fluorine, etc. inorganic elements.He Shou Crow is the root tuber of polygonum multiflorum thunb.Containing anthraquinone analog compound, main is rheum emodin, Chrysophanol and Physcion, Rhein, chrysophanic acid anthrone.Contain stilbene compound again:Resveratrol, piceid, 4 '-tetrahydroxystilbene -2-O-D- glucose Glucoside, 4 '-tetrahydroxystilbene -2-O- glycosides -2 "-O- gallates, "-O- does not have 4 '-tetrahydroxystilbene -2-O- glycosides -3 Infanticide acid esters.Also contain gallic acid, dextrorotation cachou extract, dextrorotation epicatechin, 3-O- nutgall acyls (-)-cachou extract, 3-O- does not have food Sub- acyl (-)-epicatechin, 3-O- nutgall acyls original Cyanidin, 3 '-two-O- nutgall acyls original Cyanidin and cupreol, Lecithin.Rhizoma Gastrodiae is the stem tuber of orchid rhizoma Gastrodiae.Containing gastrodin, also referred to as Gastrodin, its chemical composition is p- methylol Benzene-β-D- glucopyanosides;The another glucoside of ether containing rhizoma Gastrodiae, its chemical composition is double-(4- acrinyls)-ether-mono--β-D- glucopyras Glucoside.Again containing p- hydroxyphenylmethyl alcohol, p-hydroxy benzaldehyde, 4- acrinyl methyl ethers, 4- (4 '-hydroxyl benzyloxy) methyl benzyl ether, Double (4- acrinyls) ethers, three [4- (β-D- glucopyras glycosyloxy) benzyl] citric acid esters;The Radix Astragali is legume astragalus mongolicus Or the dry root of Astragalus membranacus.Contain 2 ', 4 ' dihydroxy -5,6- dimethoxy isoflavones, choline, beet containing Astragalus membranacus root Alkali, amino acid, sucrose, glucuronic acid and micro folic acid, sitosterol, linoleic acid and leukotrienes and asparagine, gamma-amino Butyric acid, astragalus polyose I, II, III, heteroglycan AH-1, AH-2, acidic polysaccharose AMon-S;The fruit of Chinese wolfberry is plant of Solanaceae lycium barbarum Dry mature fruit.Contain glycine betaine [1], atropine, hyoscyamine [2].Again containing the yellow matter of maize, physalin [1], Kryptoxanthin [3], Scopoletin [4], carrotene, thiamine, riboflavin, nicotinic acid, vitamin C [3].Seed contains amino acid:Asparagus fern Propylhomoserin, proline, alanine, leucine, phenylalanine, serine, glycine, glutamic acid, cysteine, lysine, smart ammonia Acid, isoleucine, threonine, histidine, cruel propylhomoserin, tryptophan, methionine [4].Also containing potassium, calcium, sodium, zinc, iron, copper, chromium, The elements such as strontium, lead, nickel, cadmium, cobalt, magnesium [5].The polysaccharide of the another immunization of promotion containing tool, content is 7.09% [6].Sulphur containing ox again Acid, tens kinds of medicinal ingredients such as γ-aminobutyric acid [7];The fruit of Chinese magnoliavine is the Schisandraceae Plant fruit of Chinese magnoliavine or the fruit of schisandra chinensis It is real.Contain a variety of lignanoids:Gomisin A, gomisin B is schisandra chinensis ester B, and gomisin C is schisandra chinensis ester A, dagger-axe rice Pungent F, G, schizandrin are wuweizi alcohol A, gomisin D [2], gomisin H, Radix Angelicae Sinensis acyl Ge meter Xin, crotonocyl Ge meter Xin, benzoic acid Ge meter Xin, GJ, preceding Ge meter Xin, meso-dihydroguaiaretic acid, Biao Ge meter Xin, dextrorotation-deoxyschisandrin is five Taste element A, GN, O, E [5], dimethyl Ge meter Xin, Gomisin P remove Radix Angelicae Sinensis acyl Ge meter Xin, left-handed-gomisin K 1 [6, 7], dextrorotation-gomisin K 2, K3 [7], tigloylgomisin P, angelic acid Gomisin P [8], Radix Angelicae Sinensis acyl Ge meter Xin Q [9], right trip- Gomisin M2, racemic-gomisin M 1;Wuweizisu B is wuweizisu B, left trip-gomisin L 1, L2 [10], Radix Angelicae Sinensis acyl dagger-axe Rice pungent O, the different Ge meter Xin of angelic acid, the different Gomisin O of benzoyl, Ge meter Xin R, schisandrin C, schisandra chinensis ester D [12], dagger-axe rice Pungent S, T [3], isoschizandrin etc.;Also contain volatile oil, its composition has α-thujene, α-and a nopinene, lauro lene, α-phellandrene, β- Terpinene, 4- terpinenols, α-terpinenol, α-(king is ancient) (king's bar) alkene, beta-elemene, acoradiene, α-and β-cedrene, Nerolidol, furfural, 32 kinds of methyln nonyl ketone and p- isopropyl acid etc..Poria cocos is the sclerotium of On Polyporaceae Poria cocos. Contain pachymic acid, 16 Alpha-hydroxy eburicoic acids, 24- wool steroid triolefins -21- acid, pachymic acid methyl esters, 16 Alpha-hydroxy eburicoic acid methyl esters, 9 (11)-DHPA methyl esters, and the sour methyl esters of 24 (31)-wool steroid triolefin -21- [3 β, total triterpenes methyl esters, the loose Siberian cocklebur of 3- hydrogenations Acid, eburicoic acid, dehydroeburicoic acid, Poria cocos eo-acid, β aromadendrol acetic acid:Pachyman, Poria cocos time poly-, octanoic acid, hendecanoic acid, the moon Cinnamic acid, lauric acid ester, palmitic acid, dodecylene acid esters, the element such as aprylic acid.Above-mentioned 8 kinds of tcm and herbal slices, have complementary functions, Effect is extensive, and brain tonic and intelligence development is often drunk by the course for the treatment of, along with necessary physical training, adjusts psychological quality, promoting blood circulationization can be played surely The stasis of blood, prevention disease, the purpose for improving body health level.
Present invention has the advantages that:There is ganoderma lucidum antitumor, hypoglycemic, hypocholesterolemic, coronary blood flow substantially to increase, hat Arteries and veins vascular resistence and myocardial oxygen consumption are reduced, with antihypertensive effect, platelet aggregation-against and anti thrombotic action, hypoglycemic effect, guarantor Liver effect, the effect of anti-oxidant, delaying senility function, antiinflammatory action, immunoregulation effect, anti-radiation;Radix Codonopsis has to be remembered to study Recall improvement result, inhibition thrombosis, oxygen lack resistant function, resist myocardial ischemia, improve cardiovascular and cerebrovascular microcirculation, antiulcer action, Strengthen immunization etc.;The fleece-flower root, which has, to be promoted memory effect, reducing blood lipid and anti arteriosclerosis, promotes hemoposieis, anti-blood small The effect such as aggregation, anti-aging, enhancing be immune;There is rhizoma Gastrodiae Central nervous system to have calm, anticonvulsant action;Substantially reduction is preced with Shape vascular resistence, increases CBF, has hypotensive, anti anoxia, promotes immunity function etc.;The Radix Astragali have anticancer, anti-aging, Antifatigue, antiviral, antibacterium, resisting stress, hypotensive, hypoglycemic, to promote cell metabolism, protection liver kidney, enhancing immune etc. more Plant effect;The fruit of Chinese wolfberry has antitumor, anti-mutation, anti-aging, anti-fatty liver, liver protection, reducing blood lipid, hypoglycemic, hypotensive, got rid of illness Salubrity, the anti-ageing effect such as lengthen the life;The fruit of Chinese magnoliavine has mental-tranquilization, anti-aging, nourishing liver and kidney, protecting liver, lowering enzymes;Control neurasthenia, Insomnia, dizziness, dim eyesight etc.;Poria cocos has mental-tranquilization, strengthening spleen and middle warmer, promote cellular immunity and humoral immune function and calmness, The effect such as antibacterial, hypoglycemic, protection liver, antitumor.
Embodiment
Specific embodiment:
1st, formulating brain tonic and intelligence development oral liquid prescription is:Ganoderma lucidum 10,10 grams of Radix Codonopsis, 10 grams of the fleece-flower root, 10 grams of rhizoma Gastrodiae, the Radix Astragali 10 Gram, 10 grams of the fruit of Chinese wolfberry, 10 grams of the fruit of Chinese magnoliavine, 10 grams of Poria cocos, honey with distillation water consumption, by 5: 5 volume measurements, preservative consumption 0.1%.
2nd, it is 1000 bottles to determine this batch brain tonic and intelligence development oral liquid output, and per bottled 200 milliliters, oral liquid need to be prepared altogether Total amount is 200 liters.
3rd, tcm and herbal slice total amount is 400 kilograms needed for being calculated by this batch brain tonic and intelligence development oral liquid output, by formula Ratio calculates 8 kinds of tcm and herbal slice amount of purchases:50 kilograms of ganoderma lucidum, 50 kilograms of Radix Codonopsis, 50 kilograms of the fleece-flower root, rhizoma Gastrodiae 50 Kilogram, 50 kilograms of the Radix Astragali, 50 kilograms of the fruit of Chinese wolfberry, 50 kilograms of the fruit of Chinese magnoliavine, 50 kilograms of Poria cocos, honey with distillation water consumption, by 5: 5 hold Product metering, preservative consumption 0.1%, 75% alcohol solvent purchases 800 liters, recycles.
4th, tcm and herbal slice is processed:Every kind of tcm and herbal slice is carried out selected and dried, after being sufficiently mixed uniformly, first with 6 Millimeter particle diameter pulverizer is crushed, then crushes standby with 3 millimeters of particle diameter pulverizers.
5th, tcm and herbal slice extracts active ingredients:Ethanol extract from water precipitation is taken to carry out, the hair designed using the applicant, applied Bright patent (July 3 2017 applying date) " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " is entered Row seepage pressure effects;The device is molten by percolating extractor support, suit cylinder percolating device, electric pump circulatory displacement device, diacolation Liquid automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent evaporating separation device, the condensation of diacolation solvent are reclaimed The part of device seven is constituted;The percolating extractor operation technological process is:1. closing diacolation solution control valve-→, it is close to open charging - → layering that capping-→ meter feedstock is fitted into inner cylinder, which is fitted into actual situation uniform-→ and adds diacolation solvent, drenches slow in circular groove-→ circular groove It is slow add diacolation solvent-→ solvent uniformly drench into raw material-→ push down circular groove should not float-→ solvent adds to and no longer drenches into away from circular groove Only circular hole in the middle part of closure is rotated to drenching into circular groove inner edge-→ and open diacolation solution circulation pump-→ regulation and oozed by-→ for 5 centimetres of bottom Solution circulating valve of filtering does not make diacolation solution spilling, and only-→ closing diacolation solution circulation pump-→ closing charging closure penetrates screw Tighten-→ and stand-→ the closing diacolation solution circulation in 36 hours of diacolation 36 hours-→ unlatching diacolation solution circulation pump circulatory displacement Through the screen pack automatic fitration of internal barrel bottom ,-→ controls pump-→ opening diacolation solution control valve-→ diacolation solution through diacolation solution Valve-→ diacolation solution flows into evaporative cylinder top screen pack natural filtration-→ filtered fluid inflow diacolation solution evaporative cylinder bottom-→ and beaten Opening charging closure ,-→ opens diacolation solution circulation pump-→ and determines whether internal barrel bottom screen pack filters and terminate-→ and 2. terminated Filter and close diacolation solution control valve-→ addition new diacolation solvent-→ progress secondary cycle seepage pressure effects (operating process and first time It is identical) after the completion of-→ secondary cycle seepage pressure effects-→ open diacolation solution control valve-→ secondary diacolation solution through internal barrel bottom Screen pack automatic fitration-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ secondary diacolation solution and flows into diacolation Solution evaporative cylinder bottom-→ with first time diacolation solution mix-→, which 3. takes out inner cylinder and pours out dregs of a decoction cleaning-→ inner cylinder, to be reentered into Outer barrel-→ closes diacolation solution control valve-→ meter feedstock and loads inner cylinder-→ and enter next seepage pressure effects program that-→ secondary oozes Solution evaporative cylinder self-filtering net filtration of filtering terminates-→ 4. connect water source-→ added water to boiler, hot water storgae, condenser-→ open Open electromagnetic stove to boiler heat-→ open hot water circulating pump-→ boiler and hot water storgae hot water start the cycle over-→ it is molten to diacolation Automatic temperature control instrument-→ regulation temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water is 5. opened in liquid evaporative cylinder heating-→ Temperature rise to 90 DEG C of electromagnetic stoves close automatically-and → hot water storgae water temperature is down to 80 DEG C of electromagnetic stove automatic opening-→ evaporative cylinder diacolation solution Solvent evaporation-→ solvent evaporate gas through gas delivery pipe-→ 6. gas feeding solvent gas merging chamber-→ solvent gas enter Spiral condensing tube is condensed into liquid-→ liquid and flows into condensing solvent recovery cylinder-→ into condensing solvent collecting chamber-→ and be put into cold Solidifying solvent storage barrel-→ recycles or storage-→ and 7. opens diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine and be put into and deposit Storage cylinder-→ preparation water sink agitator-→ water sink agitator add account for extract medicine 60% distilled water-→ be slowly added to extract medicine it is fast Speed stirring-→ the loading precipitation cylinder-→ that stirs is put into 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion and pours out supernatant Liquid-→ obtains brain tonic and intelligence development finished product and extracts medicine.
6th, brain tonic and intelligence development oral liquid finished medicines are prepared:After total extraction medicine is measured by volume, from 200 liters of oral liquid total capacity Subtract, residual capacity, honey and distillation water capacity are calculated in 5: 5 ratio, preservative is calculated by 0.1% consumption;It is standby with 300-400 rises stainless steel cylindrical vessel, and the total extraction medicine measured, honey 0000, distilled water, preservative are added into stainless steel circle Cylinder container, is mixed, first stirring at low speed during stirring, and constantly regulate is to high-speed stirred, until stirring.
7th, brain tonic and intelligence development oral liquid filling sterilization packaging:The oral liquid finished product stirred is added into filling apparatus, with 200 Milliliter volumetric flask carries out oral liquid bottling capping promoting blood circulation and removing blood stasis;Obtain oral liquid finished product promoting blood circulation and removing blood stasis;Bottled brain tonic and intelligence development is oral Liquid finished product preserves sale through high-temperature sterilization, adhesive label, mounted box vanning, storage.
8th, brain tonic and intelligence development oral liquid is taken:Oral 20 milliliters every time, 1 twice.

Claims (7)

1. brain tonic and intelligence development oral liquid prescription, it is characterized in that:Ganoderma lucidum 10,10 grams of Radix Codonopsis, 10 grams of the fleece-flower root, 10 grams of rhizoma Gastrodiae, the Radix Astragali 10 Gram, 10 grams of the fruit of Chinese wolfberry, 10 grams of the fruit of Chinese magnoliavine, 10 grams of Poria cocos, honey with distillation water consumption, by 5: 5 volume measurements, preservative consumption 0.1%.
2. brain tonic and intelligence development oral liquid materials procurement;It is characterized in that:Brain tonic and intelligence development oral liquid output is first determined, then based on formula The amount of purchase for calculating every kind of tcm and herbal slice is purchased, and the various tcm and herbal slices of buying have to comply with every kind of tcm and herbal slice Quality index and specification standards, without going mouldy, no disease and pests harm, free from admixture, pollution-free;75% etoh solvent is purchased to be drunk with Chinese medicine Piece total amount buying ratio is 2: 1.
3. brain tonic and intelligence development oral liquid raw material are processed:It is characterized in that:In addition to honey, distilled water, preservative, every kind of Chinese medicine is drunk Piece is carried out selected and dried, be sufficiently mixed it is uniform after, first with 6 millimeters of particle diameter pulverizers crushing, then with 3 millimeters of particle diameter pulverizer powder It is broken standby.
4. brain tonic and intelligence development oral liquid tcm and herbal slice extracts active ingredients:It is characterized in that:Ethanol extract from water precipitation is taken to carry out, using this " medicinal herb componentses suit cylinder electric circulation is automatic for applicant's design, the patent of invention (July 3 2017 applying date) of application Filter percolating extractor " carry out seepage pressure effects;The device is by percolating extractor support, suit cylinder percolating device, electric pump Circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent evaporation separation dress Put, the part of diacolation solvent condensate recycling device seven is constituted;The percolating extractor operation technological process is:1. diacolation solution is closed Control valve-→ opens charging closure-→ meter feedstock loading inner cylinder-→ layering loading actual situation uniform-→ and adds diacolation solvent Drench be slowly added in circular groove-→ circular groove diacolation solvent-→ solvent uniformly drench into raw material-→ push down circular groove should not float-→ it is molten Agent, which is added to, no longer drenches into 5 centimetres away from circular groove bottom only-→ and rotates circular hole in the middle part of closure to drenching into circular groove inner edge-→ and open diacolation Solution circulation pump-→ regulation diacolation solution circulating valve does not make diacolation solution overflow only-→ closing diacolation solution circulation pump-→ closing Charging closure penetrate screw tightening-→ stand diacolation 36 hours-→ open diacolation solution circulation pump circulatory displacement 36 hours-→ Close diacolation solution circulation pump-→ open diacolation solution control valve-→ diacolation solution through the screen pack automatic fitration of internal barrel bottom-→ - → diacolation solution inflow evaporative cylinder top screen pack natural filtration-→ filtered fluid inflow diacolation solution through diacolation solution control valve Open charging closure-→ and open diacolation solution circulation pump-→ and determine whether internal barrel bottom screen pack filters in evaporative cylinder bottom-→ Terminate-→ and 2. terminate filtering closing diacolation solution control valve-→ addition new diacolation solvent-→ progress secondary cycle seepage pressure effects - → opens diacolation solution control valve-→ secondary oozes after the completion of (operating process is identical with first time)-→ secondary cycle seepage pressure effects Solution of filtering through the screen pack automatic fitration of internal barrel bottom-→ flow into the top screen pack natural filtration of diacolation solution evaporative cylinder-→ it is secondary Diacolation solution flow into diacolation solution evaporative cylinder bottom-→ mixed with first time diacolation solution-→ 3. taking-up inner cylinder to pour out the dregs of a decoction clear Wash-→ inner cylinder is reentered into outer barrel-→ closes diacolation solution control valve-→ meter feedstock and load inner cylinder-→ and enter next diacolation Extraction procedure-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to boiler, hot water Groove, condenser add water-→ unlatching electromagnetic stove to boiler heating-→ unlatching hot water circulating pump-→ boiler and hot water storgae hot water Start the cycle over-→ to diacolation solution evaporative cylinder heating-→ 5. open automatic temperature control instrument-→ regulation temperature controller high temperature to 90 DEG C, it is low Temperature to 80 DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature is down to 80 DEG C of electromagnetic stoves and opens automatically Open-→ evaporative cylinder diacolation solution solvent evaporation-→ solvent evaporate gas through gas delivery pipe-→ 6. gas feeding solvent gas converge Collection room-→ solvent gas is condensed into liquid-→ liquid into condensing solvent collecting chamber-→ inflow condensation into spiral condensing tube Solvent recovery cylinder-→ is put into condensing solvent storage barrel-→ and recycles or store-→ 7. unlatching diacolation solution evaporative cylinder lower valve Door-→ coarse extraction medicine is put into storage barrel-→ heavy agitator of the heavy agitator-→ water of preparation water and adds the distillation for accounting for and extracting medicine 60% Water-→, which is slowly added to extract medicine and quickly stirs-→, stirs that to be put into 0--5 DEG C of refrigerator or freezer low temperature heavy for loading precipitation cylinder-→ Shallow lake-→ precipitation completion pours out supernatant-→ and obtains brain tonic and intelligence development finished product extraction medicine.
5. brain tonic and intelligence development oral liquid finished medicines are prepared;It is characterized in that:After total extraction medicine is measured by volume, from oral liquid total measurement (volume) amount Subtracted in 200 liters, residual volume amount, honey and distillation water capacity are calculated in 5: 5 ratio, preservative uses gauge by 0.1% Calculate;It is standby that stainless steel cylindrical vessel is risen with 300-400, the total extraction medicine measured, honey, distilled water, preservative are added stainless Steel cylindrical vessel, is mixed, first stirring at low speed during stirring, and constantly regulate is to high-speed stirred, until stirring.
6. brain tonic and intelligence development oral liquid filling sterilization packaging;It is characterized in that:The oral liquid finished product stirred is added into filling apparatus, Oral liquid bottling capping is carried out with 200 milliliters of volumetric flasks;Obtain brain tonic and intelligence development oral liquid finished product;By bottled oral liquid finished product through high temperature Sterilizing, adhesive label, mounted box vanning, storage preserves sale.
7. brain tonic and intelligence development oral liquid is taken;It is characterized in that:Oral 20 milliliters every time, 1 twice.
CN201710651250.5A 2017-07-23 2017-07-23 A kind of brain tonic and intelligence development oral liquid and its preparation technology Pending CN107260977A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115120677A (en) * 2022-07-16 2022-09-30 陕西康惠制药股份有限公司 Traditional Chinese medicine composition for tonifying kidney and soothing nerves and preparation method thereof
CN115120678A (en) * 2022-07-16 2022-09-30 陕西康惠制药股份有限公司 Traditional Chinese medicine composition for treating neurasthenia, insomnia and dreaminess and preparation method thereof
CN116350719A (en) * 2023-05-22 2023-06-30 绵阳一康制药有限公司 A kind of preparation method of compound Gastrodia elata granule

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115120677A (en) * 2022-07-16 2022-09-30 陕西康惠制药股份有限公司 Traditional Chinese medicine composition for tonifying kidney and soothing nerves and preparation method thereof
CN115120678A (en) * 2022-07-16 2022-09-30 陕西康惠制药股份有限公司 Traditional Chinese medicine composition for treating neurasthenia, insomnia and dreaminess and preparation method thereof
CN115120678B (en) * 2022-07-16 2023-05-26 陕西康惠制药股份有限公司 Preparation method of traditional Chinese medicine composition for neurasthenia, insomnia and dreaminess
CN115120677B (en) * 2022-07-16 2023-05-26 陕西康惠制药股份有限公司 Traditional Chinese medicine composition for tonifying kidney and soothing nerves and preparation method thereof
CN116350719A (en) * 2023-05-22 2023-06-30 绵阳一康制药有限公司 A kind of preparation method of compound Gastrodia elata granule

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Application publication date: 20171020