CN107293345A - The preparation method of the radioactive source source core of germanium 68 - Google Patents
The preparation method of the radioactive source source core of germanium 68 Download PDFInfo
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- CN107293345A CN107293345A CN201710410662.XA CN201710410662A CN107293345A CN 107293345 A CN107293345 A CN 107293345A CN 201710410662 A CN201710410662 A CN 201710410662A CN 107293345 A CN107293345 A CN 107293345A
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- GNPVGFCGXDBREM-FTXFMUIASA-N Germanium-68 Chemical compound [68Ge] GNPVGFCGXDBREM-FTXFMUIASA-N 0.000 title claims abstract description 70
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 36
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 32
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 claims abstract description 27
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000008367 deionised water Substances 0.000 claims abstract description 16
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 11
- 229910052732 germanium Inorganic materials 0.000 claims abstract description 11
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000012545 processing Methods 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims description 8
- 238000003672 processing method Methods 0.000 claims description 8
- NGOXCJHJHMOPMQ-UHFFFAOYSA-N [Ge].[N+](=O)(O)[O-] Chemical compound [Ge].[N+](=O)(O)[O-] NGOXCJHJHMOPMQ-UHFFFAOYSA-N 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 5
- IEXRMSFAVATTJX-UHFFFAOYSA-N tetrachlorogermane Chemical group Cl[Ge](Cl)(Cl)Cl IEXRMSFAVATTJX-UHFFFAOYSA-N 0.000 claims description 4
- 150000002290 germanium Chemical class 0.000 claims description 3
- 239000003643 water by type Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 21
- 239000006228 supernatant Substances 0.000 abstract description 15
- 238000004519 manufacturing process Methods 0.000 abstract description 9
- 230000005855 radiation Effects 0.000 abstract description 8
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 5
- 239000010808 liquid waste Substances 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 230000035484 reaction time Effects 0.000 abstract description 2
- 238000001179 sorption measurement Methods 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- QHGIKMVOLGCZIP-UHFFFAOYSA-N germanium dichloride Chemical class Cl[Ge]Cl QHGIKMVOLGCZIP-UHFFFAOYSA-N 0.000 description 8
- 238000007654 immersion Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 238000012937 correction Methods 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000011260 aqueous acid Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000000366 colloid method Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- VGRFVJMYCCLWPQ-UHFFFAOYSA-N germanium Chemical compound [Ge].[Ge] VGRFVJMYCCLWPQ-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 description 1
- 229910006113 GeCl4 Inorganic materials 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- TVFDJXOCXUVLDH-RNFDNDRNSA-N cesium-137 Chemical compound [137Cs] TVFDJXOCXUVLDH-RNFDNDRNSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 238000005025 nuclear technology Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
The invention discloses a kind of preparation method of the radioactive source source core of germanium 68, comprise the following steps：In reaction vessel, the zirconium silicate particles after processing are put into, aqueous hydrochloric acid solution, germanium saline solution and the saline solution of germanium 68 are added well mixed, oscillating reactions, abandons supernatant, is cleaned with deionized water, washes of absolute alcohol is used again, is dried at room temperature, that is, is obtained the radioactive source source core of germanium 68.The radioactive source source core radioactive activity of germanium 68 of the preparation of the present invention is evenly distributed, and the utilization rate of germanium 68 is high, and the radioactive liquid waste of generation is few.The method reaction time of the present invention is short, and operational sequence is simple and easy to control, and production efficiency is high, while using low-concentration hcl, staff's safe operation and dose of radiation are low.Chemical reagent used in the method for the present invention is conventional commercial reagent, and nontoxic, buying is convenient, and cheap, production cost is low.Zirconium silicate has high radiation resistance, and particle is uniform, and advantages of good adsorption effect is easily loaded, and loads uniformity good.
Description
Technical field
The invention belongs to nuclear technology field, specifically being related to a kind of preparation method of the radioactive source of germanium -68 source core.
Background technology
Position emission tomography (PET), also referred to as molecular imaging or biochemical imaging, are nuclear medicine development
One new technology, is the new technology of contemporary state-of-the-art non-invasive high-quality diagnostic imaging, is high-level nuclear medicine diagnostic
Mark.PET has widely applied the clinical diagnosis of various diseases and the research of preclinical medicine etc..Because detector is inconsistent
Property, isotope decay, tissue severely impact PET picture quality to isotope absorption, random error and scattering error
And diagnosis effect, often there is image fault phenomenon.Correction for attenuation is to influence one of key factor of PET image qualities, every time
Imaged using PET, it is necessary to be corrected, to ensure imaging quality and diagnosis effect.
The most frequently used radioactive source for PET correction for attenuations is germanium -68 and cesium-137 radioactive source.Generated because germanium -68 decays
The transmitting of daughter gallium-68 positive electron energy and internal positive electron energy coincidence, attenuation coefficient (ACF) closest to actual value,
It is not required to correct again, the half-life period of germanium -68 is 271d, and use time is up to more than 1 year, easy to use, it is necessary to regularly replace, therefore
The scanning that penetrates of the sealed radioactive source of germanium germanium -68 is classical transmission attenuation correction mode, is also the most-often used correction for attenuations of PET
Mode, widely application specific PET and PET-CT.
The radioactive source of germanium -68 is will to be adsorbed with the source core of radioactivity germanium -68, is loaded in stainless steel tube, two ends sealing, after sealing
Stainless steel tube be arranged in sleeve pipe and reassemble on base, that is, be made a kind of germanium [68Ge] sealed radioactive source.
The technology of preparing of the radioactive source source core of germanium -68 is the key technology of the radioactive source of germanium germanium -68, its uniformity and stability meeting
The quality of the radioactive source of germanium -68 is directly affected, and then influences the effect of correction for attenuation.The source core of the sealed radioactive source of germanium -68 makes logical
Frequently with galvanoplastic, colloid method and absorption method.Galvanoplastic be in the dilute alkaline soln containing cyanide, with68GeCu3Alloy plating
In nickel metal foil.Advantage is that source core uniformity is good, has the disadvantage complex process, it is difficult to control, and production cost is high, while also producing big
The radioactive liquid waste of amount, germanium [68Ge] utilization rate it is low, about 60%.Colloid method prepare source core be by68GeCl4Solution, gelatin
Or Carbow-1450 is well mixed at 40~50 DEG C, solidification sealing prepares PET calibration sources in injection container.Its advantage gel
The fusing point of body is relatively low (generally below 50 DEG C), and the source of germanium -68 was used after a period of time, gelinite melting can be supplemented into appropriate activity
's68Ge is reused, and manufacture craft is simple.Shortcoming must quickly stir in manufacturing process and avoid colloid solidification, manufacturing process
Temperature is higher in hardly possible control, preparation process can cause germanium -68 to volatilize, and easily adhesion causes dirt to colloid on wall during filling
The loss of dye and germanium -68.It with anion-cation exchange resin is that adsorbent prepares the source core of germanium -68 that absorption method, which is, and its advantage makes work
Skill is simpler, easy to control, and cost is relatively low, and the utilization rate of germanium -68 is 90% or so.It has the disadvantage ion exchange resin radioresistance
Can be poor, resin can cause the line uniformity of radioactive source to become big agent because of aging or broken during long-time use, and not reach
Effect is verified, so that the distortion of PET image imaging.Chinese patent ZL 2,009 1 0069323.5 discloses a kind of using resistance to
The silica of radiation be adsorbent prepared under high-concentration sulfuric acid solution germanium [68Ge] radioactive source source core method, overcome above-mentioned
The shortcoming of technology, but deficiency is still suffered from, it is that high-concentration sulfuric acid has potential safety hazard to operating personnel in operation, reaction
During produce heat but reaction temperature is raised, cause a small amount of germanium -68 to volatilize, need to centrifuge after reaction, source core clean to
Neutral required cleaning fluid volume is big, produces waste liquid amount greatly, increases waste processing cost.
The content of the invention
The purpose of the present invention is to overcome of the prior art not enough there is provided a kind of safe operation, simple for production, resistance to irradiation and
Load the preparation method of the easy radioactive source source core of germanium -68.
Technical scheme is summarized as follows：
A kind of preparation method of the radioactive source of germanium -68 source core, comprises the following steps：In reaction vessel, it is put into after processing
1-5g particle diameters be 10-100 μm of zirconium silicate particles, add 5-20mL 0.5-2M aqueous hydrochloric acid solutions, 0-2mL 0-1.5M germanium salt solution
Solution and the saline solution of 0.1-3mL 0.5-10mCi/mL germanium -68 are well mixed, and oscillating reactions 10-40min abandons supernatant, spent
Ionized water is cleaned, then with washes of absolute alcohol, is dried at room temperature, that is, obtains the radioactive source source core of germanium -68.
Zirconium silicate particles processing method is, with 1-2M aqueous hydrochloric acid solutions immersion zirconium silicate particles 5-20min, to use deionized water
Neutrality is washed till, in 200-300 DEG C of drying.
Preferably, the volume of germanium saline solution is 0.5-1.5mL, and the concentration of germanium saline solution is 0.05-1.3M.
Germanium salt is preferably germanium chloride or nitric acid germanium.
The salt of germanium -68 is preferably germanium chloride -68 or nitric acid germanium -68.
Advantages of the present invention
1. the reaction system that the method for the present invention is constituted using low concentration of salt aqueous acid and carrier germanium saline solution, with silicon
Sour zirconium particle is adsorbent, and the radioactive source source core radioactive activity of germanium -68 of preparation is evenly distributed, and the utilization rate of germanium -68 is high, generation
Radioactive liquid waste is few.
2. the method reaction time of the present invention is short, operational sequence is simple and easy to control, and production efficiency is high, while using low concentration of salt
Acid, staff's safe operation and dose of radiation are low.
3. chemical reagent used in the method for the present invention is conventional commercial reagent, nontoxic, buying is convenient, and price is just
Preferably, production cost is low.
4th, zirconium silicate has high radiation resistance, and particle is uniform, and advantages of good adsorption effect is easily loaded, and loads uniformity good.
Embodiment
With reference to specific embodiment, the present invention is further illustrated.
The chemical reagent used in all embodiments is that analysis is pure.
Embodiment 1
A kind of preparation method of the radioactive source of germanium -68 source core, comprises the following steps：
In reaction vessel, it is 20 μm of zirconium silicate particles to be put into the 1g particle diameters after processing, adds 5mL 2M hydrochloric acid water-soluble
Liquid, the 1.5mL 0.5M germanium chlorides aqueous solution and the aqueous solution of 3mL 0.5mCi/mL germanium chlorides -68 are well mixed, oscillating reactions
40min, abandons supernatant, is cleaned with deionized water 2 times, then with washes of absolute alcohol 1 time, dries at room temperature, that is, obtains the radiation of germanium -68
Core in a steady stream.
Zirconium silicate particles processing method be with 1M aqueous hydrochloric acid solutions immersion zirconium silicate particles 20min, be washed with deionized water to
Neutrality, in an oven 200 DEG C of drying.
The utilization rate of radioactivity germanium -68=(- 68 activity of radioactivity germanium/activity of input radioactivity germanium -68 in 1- supernatants) ×
100%
The activity of radioactivity germanium -68 is 0.03mCi in supernatant, and the activity of input radioactivity germanium -68 is 1.5mCi, radioactivity
The utilization rate of germanium -68 is 98%.
Embodiment 2
A kind of preparation method of the radioactive source of germanium -68 source core, comprises the following steps：
In reaction vessel, it is 10 μm of zirconium silicate particles to be put into the 1.5g particle diameters after processing, adds 10mL 0.5M hydrochloric acid
The aqueous solution, the 0.5mL 0.05M germanium chlorides aqueous solution and the aqueous solution of 0.1mL 10mCi/mL germanium chlorides -68 are well mixed, and vibration is anti-
10min is answered, supernatant is abandoned, is cleaned with deionized water 2 times, then with washes of absolute alcohol 1 time, dries at room temperature, that is, obtains germanium -68 and put
Penetrate core in a steady stream.
Zirconium silicate particles processing method be with 1.5M aqueous hydrochloric acid solutions immersion zirconium silicate particles 5min, be washed with deionized water to
Neutrality, in an oven 250 DEG C of drying.
The activity of radioactivity germanium -68 is 0.025mCi in supernatant, and the activity of input radioactivity germanium -68 is 1.0mCi, radioactivity
The utilization rate of germanium -68 is 97.5%.
Embodiment 3
A kind of preparation method of the radioactive source of germanium -68 source core, comprises the following steps：
In reaction vessel, it is 80 μm of zirconium silicate particles to be put into the 5g particle diameters after processing, adds 20mL 1.5M hydrochloric acid waters
Solution, the 2mL 1.5M germanium chlorides aqueous solution and the aqueous solution of 3.0mL 5mCi/mL germanium chlorides -68 are well mixed, oscillating reactions
30min, abandons supernatant, is cleaned with deionized water 2 times, then with washes of absolute alcohol 1 time, dries at room temperature, that is, obtains the radiation of germanium -68
Core in a steady stream.
Zirconium silicate particles processing method be with 2M aqueous hydrochloric acid solutions immersion zirconium silicate particles 15min, be washed with deionized water to
Neutrality, in an oven 300 DEG C of drying.
The activity of radioactivity germanium -68 is 0.113mCi in supernatant, and the activity of input radioactivity germanium -68 is 7.5mCi, radioactivity
The utilization rate of germanium -68 is 98.5%.
Embodiment 4
A kind of preparation method of the radioactive source of germanium -68 source core, comprises the following steps：
In reaction vessel, it is 100 μm of zirconium silicate particles to be put into the 2.5g particle diameters after processing, adds 15mL 1M hydrochloric acid
The aqueous solution, the 1.5mL 1.3M nitric acid germanium aqueous solution and the aqueous solution of 2.5mL 10mCi/mL nitric acid germanium -68 are well mixed, oscillating reactions
15min, abandons supernatant, is cleaned with deionized water 2 times, then with washes of absolute alcohol 1 time, dries at room temperature, that is, obtains the radiation of germanium -68
Core in a steady stream.
Zirconium silicate particles processing method is, with 1.5M aqueous hydrochloric acid solutions immersion zirconium silicate particles 18min, to be washed with deionized water
To neutral, 250 DEG C of drying in an oven.
The activity of radioactivity germanium -68 is 0.875mCi in supernatant, and the activity of input radioactivity germanium -68 is 25mCi, radioactivity
The utilization rate of germanium -68 is 96.5%.
Embodiment 5
A kind of preparation method of the radioactive source of germanium -68 source core, comprises the following steps：
In reaction vessel, it is 100 μm of zirconium silicate particles to be put into the 2.5g particle diameters after processing, adds 12mL 1.3M salt
Aqueous acid, the 1.5mL 0.5M germanium chlorides aqueous solution and the aqueous solution of 2.0mL 8mCi/mL germanium chlorides -68 are well mixed, and vibration is anti-
30min is answered, supernatant is abandoned, is cleaned with deionized water 2 times, then with washes of absolute alcohol 1 time, dries at room temperature, that is, obtains germanium -68 and put
Penetrate core in a steady stream.
Zirconium silicate particles processing method be with 1M aqueous hydrochloric acid solutions immersion zirconium silicate particles 10min, be washed with deionized water to
Neutrality, in an oven 220 DEG C of drying.
The activity of radioactivity germanium -68 is 0.400mCi in supernatant, and the activity of input radioactivity germanium -68 is 16mCi, radioactivity
The utilization rate of germanium -68 is 97.5%.
Embodiment 6
A kind of preparation method of the radioactive source of germanium -68 source core, comprises the following steps：
In reaction vessel, it is 30 μm of zirconium silicate particles to be put into the 1.5g particle diameters after processing, adds 8mL 1.2M hydrochloric acid
The aqueous solution, the saline solution of 1.5mL 4mCi/mL nitric acid germanium -68 are well mixed, and oscillating reactions 25min abandons supernatant, uses deionized water
Cleaning 2 times, then with washes of absolute alcohol 1 time, dry at room temperature, that is, obtain the radioactive source source core of germanium -68.
Zirconium silicate particles processing method be with 1M aqueous hydrochloric acid solutions immersion zirconium silicate particles 10min, be washed with deionized water to
Neutrality, in an oven 250 DEG C of drying.
The activity of radioactivity germanium -68 is 0.096mCi in supernatant, puts into the activity of radioactivity germanium -68 for 6mCi, radioactivity germanium -
68 utilization rates are 98.3%.
The radioactive source of germanium -68 prepared according to the method for embodiment 1 is with SANDERS companies of the U.S. in GE Discovery ST
PET-C has carried out 3D sweep tests, and radiocounting is read every 2cm, calculates the uniformity of the radioactive source of radioactivity germanium -68, experiment
It the results are shown in Table 1.
Radioactive source prepared by the product of the embodiment 1 of table 1 is compared with U.S. SANDERS Products uniformities
Claims (5)
1. a kind of preparation method of the radioactive source of germanium -68 source core, it is characterized in that comprising the following steps：In reaction vessel, be put into through
1-5g particle diameters after processing are 10-100 μm of zirconium silicate particles, add 5-20mL 0.5-2M aqueous hydrochloric acid solutions, 0-2mL 0-1.5M
Germanium saline solution and the saline solution of 0.1-3mL 0.5-10mCi/mL germanium -68 are well mixed, and oscillating reactions 10-40min is abandoned
Clearly, cleaned, then with washes of absolute alcohol, dried at room temperature with deionized water, that is, obtain the radioactive source source core of germanium -68.
2. according to the method described in claim 1, it is characterized in that described zirconium silicate particles processing method is to use 1-2M hydrochloric acid waters
Solution soaks zirconium silicate particles 5-20min, is washed with deionized water to neutrality, in 200-300 DEG C of drying.
3. according to the method described in claim 1, it is characterized in that the volume of germanium saline solution is 0.5-1.5mL, germanium saline solution
Concentration be 0.05-1.3M.
4. the method according to claim 1 or 3, it is characterized in that the germanium salt is germanium chloride or nitric acid germanium.
5. according to the method described in claim 1, it is characterized in that the described salt of germanium -68 is germanium chloride -68 or nitric acid germanium -68.
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| US20140263074A1 (en) * | 2011-10-21 | 2014-09-18 | Nagasaki University | GE ADSORBENT FOR 68Ge-68Ga GENERATOR |
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|---|---|---|---|---|
| TW436814B (en) * | 2000-05-04 | 2001-05-28 | Inst Of Nuclear Energy Res Roc | A novel method for fabrication of germanium-68 sealed sources |
| CN101593567A (en) * | 2009-06-18 | 2009-12-02 | 天津赛德生物制药有限公司 | 68The preparation method of Ge sealed radioactive source |
| CN101777399A (en) * | 2010-02-03 | 2010-07-14 | 中国原子能科学研究院 | PET attenuation correction method68Preparation process of Ge line source |
| CN102382994A (en) * | 2011-07-18 | 2012-03-21 | 原子高科股份有限公司 | Radioactivity68Preparation method of Ge solution |
| US20140263074A1 (en) * | 2011-10-21 | 2014-09-18 | Nagasaki University | GE ADSORBENT FOR 68Ge-68Ga GENERATOR |
| CN105308687A (en) * | 2013-06-27 | 2016-02-03 | 马林克罗特有限公司 | Process of generating germanium |
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| CN107293345B (en) | 2019-06-04 |
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