[go: up one dir, main page]

CN107205957A - 贴剂 - Google Patents

贴剂 Download PDF

Info

Publication number
CN107205957A
CN107205957A CN201680008513.4A CN201680008513A CN107205957A CN 107205957 A CN107205957 A CN 107205957A CN 201680008513 A CN201680008513 A CN 201680008513A CN 107205957 A CN107205957 A CN 107205957A
Authority
CN
China
Prior art keywords
patch
adhesive layer
hydrochloride
woven fabrics
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201680008513.4A
Other languages
English (en)
Other versions
CN107205957B (zh
Inventor
中岛健太郎
佐藤昌宏
古濑靖久
义永隆明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Publication of CN107205957A publication Critical patent/CN107205957A/zh
Application granted granted Critical
Publication of CN107205957B publication Critical patent/CN107205957B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A61F13/0243—Adhesive bandages or dressings wound covering film layers without a fluid retention layer characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/14—Layered products comprising a layer of metal next to a fibrous or filamentary layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/12—Layered products comprising a layer of synthetic resin next to a fibrous or filamentary layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/302—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising aromatic vinyl (co)polymers, e.g. styrenic (co)polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/304—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/40—Layered products comprising a layer of synthetic resin comprising polyurethanes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B29/00—Layered products comprising a layer of paper or cardboard
    • B32B29/02—Layered products comprising a layer of paper or cardboard next to a fibrous or filamentary layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
    • B32B5/022—Non-woven fabric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/22—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed
    • B32B5/24—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer
    • B32B5/26—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer another layer next to it also being fibrous or filamentary
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/06—Interconnection of layers permitting easy separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J125/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Adhesives based on derivatives of such polymers
    • C09J125/02—Homopolymers or copolymers of hydrocarbons
    • C09J125/04—Homopolymers or copolymers of styrene
    • C09J125/08—Copolymers of styrene
    • C09J125/10—Copolymers of styrene with conjugated dienes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J7/00—Adhesives in the form of films or foils
    • C09J7/20—Adhesives in the form of films or foils characterised by their carriers
    • C09J7/21—Paper; Textile fabrics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00646—Medication patches, e.g. transcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00655—Plasters adhesive
    • A61F2013/00659—Plasters adhesive polymeric base
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B32B2262/0223—Vinyl resin fibres
    • B32B2262/0238—Vinyl halide, e.g. PVC, PVDC, PVF, PVDF
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B32B2262/0246—Acrylic resin fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B32B2262/0253—Polyolefin fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B32B2262/0261—Polyamide fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B32B2262/0276—Polyester fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/02—Synthetic macromolecular fibres
    • B32B2262/0292—Polyurethane fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/04—Cellulosic plastic fibres, e.g. rayon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/06—Vegetal fibres
    • B32B2262/062—Cellulose fibres, e.g. cotton
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/08—Animal fibres, e.g. hair, wool, silk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/50—Properties of the layers or laminate having particular mechanical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/732—Dimensional properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/748—Releasability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2535/00—Medical equipment, e.g. bandage, prostheses or catheter

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Textile Engineering (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Laminated Bodies (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明公开一种贴剂，其是具有支持体和层叠于支持体上的黏着剂层的贴剂，支持体包含射流喷网成布法无纺布或由射流喷网成布法无纺布所构成，黏着剂层包含SIS嵌段共聚物及液体石蜡，贴剂具有作为规定的基准轴方向的第1方向与和第1方向成直角的第2方向，贴剂的第1方向的硬挺度为18～30mm。

Description

贴剂
【技术领域]
本发明涉及贴剂。
【现有技术]
市面上销售为了缓和肩、肘、膝及腰的疼痛而于支持体上层叠有掺合了消炎镇痛剂等之药物的黏着剂层的硬膏贴剂(硬膏剂)。如此的贴剂当中于支持体使用了织布的贴剂是由于伸缩性优异，容易追随皮肤的伸缩，因此附着性优异。但，于支持体使用了织布的贴剂有所谓的「硬度」(firmness)弱的倾向。因而，在将贴剂贴附于患处时有时会因突然折弯使黏着面彼此黏住，而有难以将贴剂进行黏贴的倾向。
另一方面，也开发有于支持体使用了无纺布的贴剂。与于支持体使用了织布的贴剂相比，于支持体使用了无纺布的贴剂有「硬度」的问题获得改善的倾向，但有产生所谓的冷流(cold flow)而黏着剂层的成分容易从支持体渗出的倾向。
[现有技术文献]
[专利文献]
[专利文献1]日本特开2001-328935号公报
【发明内容]
[发明所欲解决的课题]
本发明目的是，提供黏贴容易度优异，且黏着剂层的成分不会从支持体渗出的贴剂。
[用以解决课题的手段]
本发明人是鉴于上述情况而进行努力探讨。其结果，本发明人发现通过将包括水针(水针法(射流喷网成布法))无纺布或由水针(水针法(射流喷网成布法))无纺布所构成的支持体，与包含苯乙烯-异戊二烯-苯乙烯嵌段共聚物及液体石蜡的黏着剂层进行组合，且，将贴剂的刚软度(抗弯性，硬挺度)设为18～30mm，而解决上述课题。
也即，本发明提供了一种贴剂，其是具有支持体和层叠于支持体上的黏着剂层的贴剂，支持体包含水针(水针法(射流喷网成布法))无纺布或由水针(水针法(射流喷网成布法))无纺布所构成，黏着剂层包含苯乙烯-异戊二烯-苯乙烯嵌段共聚物及液体石蜡，贴剂具有作为规定的基准轴方向的第1方向与和第1方向成直角的第2方向，以JIS L 1085：1998中规定的45°悬臂法(カンチレバー法)测定的贴剂的第1方向的刚软度(抗弯性，硬挺度)为18～30mm。
于上述黏着剂层中的苯乙烯-异戊二烯-苯乙烯嵌段共聚物与液体石蜡的质量比可为1～1.65：1。上述黏着剂层也可包含水杨酸甲酯及薄荷醇。上述黏着剂层也可包含聚异丁烯。上述黏着剂层也可包含萜烯树脂。上述黏着剂层可以黏着剂层的总质量为基准计，包含9～11质量％的水杨酸甲酯及2.5～6.5质量％的薄荷醇，或者，也可以黏着剂层的总质量为基准计，包含23.7～32.5质量％的苯乙烯-异戊二烯-苯乙烯嵌段共聚物、17.9～27.5质量％的液体石蜡、9～11质量％的水杨酸甲酯、3～6质量％的薄荷醇、3～12质量％的聚异丁烯及17～25质量％的萜烯树脂。
或者，上述无纺布的单位面积重量可为90～110g/m2。上述无纺布的宽度方向的20％模量可为3～5N/50mm。上述无纺布的宽度方向的50％模量可为8～15N/50mm。上述无纺布可由聚酯所构成。以JIS L 1085：1998中规定的45°悬臂法测定的贴剂的第1方向的刚软度(抗弯性，硬挺度)可为18～27mm。
[发明效果]
本发明的贴剂是由于具有「硬度」因此容易黏贴。或者，不易产生黏着剂层的成分的冷流。
【用于实施发明的方式]
本实施方式的贴剂具有支持体和层叠于支持体上的黏着剂层。支持体包含水针(水针法(射流喷网成布法))无纺布或由水针(水针法(射流喷网成布法))无纺布所构成，黏着剂层包含苯乙烯-异戊二烯-苯乙烯嵌段共聚物及液体石蜡。贴剂具有作为规定的基准轴方向的第1方向，与和第1方向成直角的第2方向，贴剂的第1方向的刚软度(抗弯性，硬挺度)为18～30mm。
于本说明书中，刚软度(抗弯性，硬挺度)意味着以JIS L 1085：1998中规定的45°悬臂法测定的刚软度(抗弯性，硬挺度)。也即，刚软度(抗弯性，硬挺度)意味着，在具有45°之斜面且上面具备有刻度的表面的光滑的水平台之上，配置宽2cm的试验片(贴剂或支持体)以使其短边与刻度的基线成为一致，当使试验片往前述斜面的方向缓慢地滑动时，直到试验片的一方的短边的中央点与前述斜面接触为止，试验片所移动的距离(mm)。贴剂的第1方向的刚软度(抗弯性，硬挺度)意味着，当使试验片沿着第1方向在斜面缓慢地滑动时的刚软度(抗弯性，硬挺度)。
水针(水针法(射流喷网成布法))无纺布意味着以对纤维喷射高压的水流使其盘绕之所谓的水流络合法所形成之无纺布。水针(水针法(射流喷网成布法))无纺布的原料可列举：聚对苯二甲酸乙二酯(PET)等的聚酯、乙烯-乙酸乙烯酯共聚物(EVA)、氯乙烯、聚乙烯及聚丙烯等的聚烯烃、丁二烯-苯乙烯-甲基丙烯酸甲酯共聚合树脂、耐纶(尼龙)、聚氨酯(聚氨基甲酸乙酯,聚氨基甲酸酯)、烷氧烷基(甲基)丙烯酸酯共聚物、聚乙烯缩醛、聚酰胺及人造丝(人造纤维)等的合成树脂、棉花(木綿)、羊毛、丝等的天然素材。就贴剂的黏贴容易度的观点而言，水针(水针法(射流喷网成布法))无纺布优选为由聚酯所构成的水针(水针法(射流喷网成布法))无纺布。纤维的直径优选为5～15μm。
水针(水针法(射流喷网成布法))无纺布的单位面积重量为例如50g/m2以上，优选为70g/m2以上，更优选为90g/m2以上。若水针(水针法(射流喷网成布法))无纺布的单位面积重量为上述下限值以上，则会变得不易产生黏着剂层的成分的渗出。水针(水针法(射流喷网成布法))无纺布的单位面积重量为例如200g/m2以下，优选为150g/m2以下，更优选为125g/m2以下。若为上述上限值以下，则在贴剂的贴附时会变得不易产生不舒适感。就贴剂的黏贴容易度的观点而言，水针(水针法(射流喷网成布法))无纺布的单位面积重量特别优选为90～110g/m2或100～110g/m2。
水针(水针法(射流喷网成布法))无纺布具有机器方向(machine direction)(流向或纵向)及交叉方向(cross direction)(宽度方向或横向)。水针(水针法(射流喷网成布法))无纺布的伸缩性，例如，流向的50％模量为200～400N/50mm，宽度方向的50％模量为5～15N/50mm。伸缩性的测定基于JIS L 1096：2010所规定的定伸长时伸长力。若水针(水针法(射流喷网成布法))无纺布的伸缩性为上述范围内，则变得容易追随贴剂的贴附部位的皮肤之伸缩。就贴剂的黏贴容易度的观点而言，水针(水针法(射流喷网成布法))无纺布的伸缩性优选流向的20％模量为40～90N/50mm，更优选为55～75N/50mm，优选宽度方向的20％模量为3～5N/50mm，更优选为3.6～4.4N/50mm，优选流向的50％模量为150～350N/50mm，更优选为220～300N/50mm，优选宽度方向的50％模量为8～15N/50mm，更优选为11.2～11.7N/50mm。水针(水针法(射流喷网成布法))无纺布的宽度方向及流向优选分别与贴剂的第1方向及第2方向一致。
水针(水针法(射流喷网成布法))无纺布的宽度方向的刚软度(抗弯性，硬挺度)优选为18～30mm。若水针(水针法(射流喷网成布法))无纺布的宽度方向的刚软度(抗弯性，硬挺度)为上述范围内，则在制作包括水针(水针法(射流喷网成布法))无纺布或由水针(水针法(射流喷网成布法))无纺布所构成的支持体上层叠有黏着剂层的贴剂时，可容易将贴剂的第1方向的刚软度(抗弯性，硬挺度)设为所期望的范围。贴剂的第1方向的刚软度(抗弯性，硬挺度)为18～30mm，就贴剂的黏贴容易度的观点而言，优选为18～27mm或21～27mm。
支持体可使用作为水针(水针法(射流喷网成布法))无纺布而市售的制品，如此的制品是由例如Unitika股份有限公司(ユニチカ株式会社)、Kuraray Kuraflex股份有限公司(クラレクラフレックス株式会社)、股份有限公司Yuho(株式会社ユウホウ)、DaiwaboPolytec股份有限公司(ダイワボウポリテック株式会社)及日本Vilene股份有限公司(日本バイリーン株式会社)等所销售。
黏着剂层包含苯乙烯-异戊二烯-苯乙烯嵌段共聚物(以下，有时称为SIS或SIS嵌段共聚物)及液体石蜡。通过将包含这些的成分的黏着剂层与水针(水针法(射流喷网成布法))无纺布组合，而可增强贴剂的「硬度」，而使贴剂变得容易黏贴。
可使用作为SIS嵌段共聚物而市售的制品，作为如此的制品可列举：CARIFLEX(カリフレックス)TR-1107、CARIFLEX TR-1111、CARIFLEX TR-1112、CARIFLEX TR-1117(以上，Shell Chemicals股份有限公司(シェル化学株式会社)制)、JSR5000、JSR5002、JSR5100(以上，JSR股份有限公司制)及Quintac(クインタック)3570C(日本ZEON股份有限公司(日本ゼオン株式会社)制)。
黏着剂层中的SIS嵌段共聚物的含量，相对于黏着剂层总质量，例如，为10质量％以上，优选为15质量％以上，更优选为20质量％以上。具备有包含上述下限值以上的SIS嵌段共聚物的黏着剂层的贴剂，在必要的贴附期间中贴剂不从皮肤剥离，且具有充分的「硬度」。黏着剂层中的SIS嵌段共聚物的含量，相对于黏着剂层总质量，例如，为50质量％以下，优选为40质量％以下，更优选为30质量％以下。具备有包含上述上限值以下的SIS嵌段共聚物的黏着剂层的贴剂，在将贴剂剥离时无伴随疼痛等的使用性优异。就贴剂的黏贴容易度的观点而言，黏着剂层中的SIS嵌段共聚物的含量特别优选为23.7～32.5质量％。
黏着剂层中的液体石蜡的含量，相对于黏着剂层总质量，例如，为5质量％以上，优选为10质量％以上，更优选为15质量％以上。具备有包含上述下限值以上的液体石蜡的黏着剂层的贴剂具有充分的黏着性。黏着剂层中的液体石蜡的含量，相对于黏着剂层总质量，例如，为50质量％以下，优选为40质量％以下，更优选为30质量％以下。具备有包含上述上限值以下的液体石蜡的黏着剂层的贴剂是由于具备有适度的柔软性，因此变得容易黏贴。就贴剂的黏贴容易度的观点而言，黏着剂层中的液体石蜡的含量特别优选为17.9～27.5质量％。
或者，黏着剂层中的SIS嵌段共聚物与液体石蜡的质量比优选为1～1.65：1。若以该比率掺合两者，则可增强贴剂的「硬度」，而使贴剂变得容易黏贴。或者，若以该比率掺合两者，则可将黏着剂层调整成适度的硬度，在制造时，在黏着剂层中不易产生气泡，而制造适合性优异。进而，若以该比率掺合两者，则也变得容易防止冷流。
黏着剂层可因应需要而包含SIS嵌段共聚物以外的黏着剂、液体石蜡以外的增塑剂，也可包含赋黏剂(粘着付与剤)、吸收促进剂、抗氧化剂、填充剂、交联剂、防腐剂、紫外线吸收剂、界面活性剂(表面活性剂)、pH调整剂、色素及香料等的添加剂。
作为SIS嵌段共聚物以外的黏着剂可列举：天然橡胶、合成异戊二烯橡胶、聚异丁烯、聚乙烯醚、聚氨酯(聚氨基甲酸乙酯,聚氨基甲酸酯)、聚异戊二烯、聚丁二烯、苯乙烯-丁二烯共聚物及苯乙烯-异戊二烯共聚物。黏着剂层优选为包含聚异丁烯。通过使用聚异丁烯而可提升黏着力。黏着剂层中的聚异丁烯的含量例如1～20质量％，优选为2～15质量％。就贴剂的黏贴容易度的观点而言，黏着剂层中的聚异丁烯的含量特别优选为3～12质量％。
作为液体石蜡以外的增塑剂可列举：聚丁烯、液状聚异丁烯及动植物油。
作为赋黏剂可列举：脂环族饱和烃树脂(荒川化学工业公司(荒川化学工業社)制，商品名：Alcon(アルコン)P-100等)、氢化松香酯(水素添加ロジンエステル)(荒川化学工业公司制，商品名：KE-311、KE-100；HERCULES公司(ハーキュレス社)制，商品名：FORAL(フォーラル)105、FORAL 85等)、氢化脂环族系烃(Exon Chemical公司(エクソン化学社)制，商品名：ESCOREZ(エスコレッツ)5300等)、萜烯树脂、石油树脂及酚树脂。赋黏剂当中，由α-蒎烯及β-蒎烯等所构成的萜烯树脂是由于提高黏着力的作用优异，而为优选的。在将SIS嵌段共聚物及液体石蜡以1～1.65：1之比率掺合在黏着剂层中的情况下，有黏着剂层的黏着力降低的倾向。在如此的情况中，可通过萜烯树脂的使用，而提升黏着力。就黏着力提升的观点而言，黏着剂层中的萜烯树脂的含量特别优选为17～25质量％。
作为吸收促进剂可列举：肉豆蔻酸异丙酯、癸二酸二乙酯、脱水山梨糖醇单月桂酸酯、油基磷酸钠(oleyl phosphoric acid sodium)(オレイルリン酸ナトリウム)、月桂基硫酸钠、辛基苯基醚、月桂基醚、脱水山梨糖醇单月桂酸酯、月桂酰二乙醇酰胺(ラウロイルジエタノールアミド)、月桂酰肌氨酸、油酰肌氨酸糖酯(オレオイルサルコシンシュガーエステル)、卵磷酯、甘草酸、脲、水杨酸、硫代乙醇酸钙、乳酸、乳酸酯、橄榄油、角鲨烯、羊毛脂及甘油。
作为抗氧化剂可列举：生育酚及其酯衍生物、抗坏血酸、抗坏血酸硬脂酸酯、去甲二氢愈创木酸(nordihydroguaiaretic acid)、二丁基羟基甲苯及丁基羟基甲氧苯(アソニール)。
作为填充剂可列举：碳酸钙、碳酸镁、硅酸盐(例如，硅酸铝、硅酸镁等)、硅酸、硫酸钡、硫酸钙、锌酸钙(calcium plumbite)、氧化锌、氧化钛及硬脂酸锌。
作为交联剂可列举：热硬化性树脂(氨基树脂、酚树脂、环氧树脂、醇酸树脂及不饱和聚酯等)、异氰酸酯化合物及封端异氰酸酯化合物等的有机系交联剂、金属及金属化合物等的无机系交联剂。
作为防腐剂可列举：对羟基苯甲酸乙酯、对羟基苯甲酸丙酯及对羟基苯甲酸丁酯。
作为紫外线吸收剂可列举：p-氨基苯甲酸衍生物、邻氨基苯甲酸(anthranilicacid)衍生物、水杨酸衍生物、香豆素衍生物、氨基酸(胺酸)系化合物、咪唑啉衍生物、吡啶衍生物及二氧六环衍生物。
黏着剂层中所含有的药物并无特别限定，可列举例如：乙酰氨基酚、非那西汀(phenacetin)、甲芬那酸(Mefenamic Acid)、双氯芬酸钠(Diclofenac Sodium)、氟芬那酸(Flufenamic Acid)、阿斯匹林、水杨酸钠、水杨酸甲酯、水杨酸乙二醇酯、氨基吡啉(ピリン)、阿氯芬酸(Alclofenac)、布洛芬(Ibuprofen)、萘普生(Naproxen)、氟比洛芬(Flurbiprofen)、酮洛芬(Ketoprofen)、氨芬酸钠(Amfenac sodium)、甲嘧啶唑(Mepirizole)、吲哚美辛(Indomethacin)、吡罗昔康(Piroxicam)及联苯乙酸(Felbinac)(フェルビナク)等的消炎镇痛剂；氢化可的松、曲安西龙、地塞米松及泼尼松龙等的类固醇系抗炎剂；盐酸地尔硫卓(Diltiazem Hydrochloride)、季戊四醇四硝酸酯、异山梨醇硝酸酯、曲匹地尔(Trapidil)(タラジピル)、尼可地尔(Nicorandil)(ニコランジル)、硝化甘油、乳酸普尼拉明(prenylamine lactate)、吗多明(Molsidomine)(モルシドミン)、亚硝酸铝、盐酸妥拉唑啉(Tolazoline hydrochloride)及硝苯地平(Nifedipine)等的血管扩张剂；盐酸普鲁卡因胺(Procainamide Hydrochloride)、盐酸利多卡因(LidocaineHydrochloride)、盐酸普萘洛尔(Propranolol Hydrochloride)、盐酸阿普洛尔(Alprenolol Hydrochloride)、阿替洛尔(Atenolol)、纳多洛尔(Nadolol)、酒石酸美托洛尔(Metoprolol Tartrate)、阿马林(Ajmaline)、丙吡胺(ジソピラミド)及盐酸美西律(Mexiletine Hydrochloride)等的抗心律不整剂(Antiarrhythmic agents)(不整脈用剤)；盐酸托屈嗪(Ecarazine hydrochloride)(塩酸エカラジン)、吲达帕胺(Indapamide)、盐酸可乐定(Clonidine Hydrochloride)、盐酸丁丙诺非(Buprenorphine Hydrochloride)(塩酸ブニトロロール)、盐酸拉贝洛尔(Labetalol Hydrochloride)、卡托普利(Captopril)、乙酸胍那苄(Guanabenz acetate)(酢酸グアナベンズ)、美布氨酯(mebutamate)及硫酸苄胍(Bethanidine Sulfate)(硫酸ベタニジン)等的降血压剂；柠檬酸喷托维林(Carbetapentane Citrate)、氯哌斯汀(Cloperastine)(クロペラスチン)、鞣酸奥昔拉定(oxeladin tannate)、盐酸氯布奇诺(Kuropuchinoru Hydrochloride)(塩酸クロプチノール)、盐酸氯苯达诺(Chlophedianol Hydrochloride)、盐酸那可丁(NoscapineHydrochloride)、盐酸麻黄碱(Ephedrine Hydrochloride)(塩酸エフェドリン)、盐酸异丙基肾上腺素、盐酸氯丙那林(Kuroripurenarin Hydrochloride)(塩酸クロリプレナリン)、盐酸甲氧那明(Methoxyphenamine hydrochloride)、盐酸丙卡特罗(ProcaterolHydrochloride)、盐酸妥洛特罗(Tulobuterol Hydrochloride)、盐酸克仑特罗(Clenbuterol Hydrochloride)(塩酸クレンプテロール)及富马酸酮替芬(KetotifenFumarate)等的镇咳去痰剂；环磷酰胺、氟尿嘧啶、替加氟(tegafur)(デガフール)、丝裂霉素C、盐酸丙卡巴肼(Procarbazine Hydrochloride)、脱氧氟尿苷(Doxifluridine)(ドキシフルリジン)及雷莫司汀(Ranimustine)(ラニムスチン)等的抗恶性肿瘤剂；氨基苯甲酸乙酯、盐酸丁卡因(Tetracaine Hydrochloride)、盐酸普卡因(Procaine Hydrochloride)(塩酸ブロカイン)、盐酸地布卡因(Dibucaine Hydrochloride)、盐酸丁氧普鲁卡因(Oxybuprocaine Hydrochloride)(塩酸オキシブプロカイン)及盐酸丙胺卡因(Propitocaine hydrochloride)(塩酸プロピトカイン)等的局部麻醉剂；丙硫氧嘧啶、甲巯咪唑、乙酸美替诺龙(methenolone acetate)(酢酸メテロノン)、雌二醇(oestradiol)、雌三醇(estriol)及孕甾酮等的激素剂；盐酸苯海拉明(Diphenhydramine Hydrochloride)、马来酸氯苯那敏(Chlorpheniramine Maleate)、异丙嗪(promethazine)、盐酸塞浦希他啶(Cyproheptadine Hydrochloride)(塩酸ジプロヘプタジン)及盐酸二苯拉林(Diphenylpyraline Hydrochloride)等的抗组织胺剂；华法林钾(warfarin potassium)及盐酸噻氯匹定(Ticlopidine Hydrochloride)等的抗凝血剂；溴化甲基阿托品(atropinemethyl bromide)及东莨菪碱(Scopolamine)等的解痉药；硫喷妥钠(sodium thiopental)及戊巴比妥钠(Pentobarbital Sodium)等的全身麻醉剂；溴异戊酰胺(bromvalerylurea)、异戊巴比妥(Amobarbital)及苯巴比妥(Phenobarbital)等的催眠/镇痛剂；苯妥英钠等的抗癫痫剂；盐酸脱氧麻黄碱等的兴奋剂/觉醒剂；盐酸地芬尼多(DiphenidolHydrochloride)(塩酸ジフェンドール)及甲磺酸倍他司汀(Betahistine Mesylate)等的镇晕剂(鎮暈剤)；盐酸氯丙嗪(Chlorpromazine Hydrochloride)、硫利达嗪(Thioridazine)、甲丙氨酯(安宁片)(Meprobamate)、盐酸丙咪嗪(ImipramineHydrochloride)、氯氮卓(利眠宁)(chlordiazepoxide)及地西泮等的精神神经用剂；盐酸琥珀酰胆碱(Suxamethonium Hydrochloride)及盐酸乙哌立松(EperisoneHydrochloride)等的骨骼肌肉松弛剂；溴化新斯的明(neostigmine bromide)及氯贝胆碱等的自律神经(植物性神经、自主神经)用剂；盐酸金刚胺(Amantadine Hydrochloride)等的抗巴金森氏剂(抗パーキンソン剤)；氢氟甲苯噻(Hydroflumethiazide)(ヒドロフルメチアジド)、异山梨醇及呋塞米(Furosemide)等的利尿剂；盐酸去氧肾上腺素(Phenylephrine Hydrochloride)等的血管收缩剂；溴化洛贝林、双吗啉胺(dimorpholamine)及盐酸纳洛酮(Naloxone Hydrochloride)等的呼吸促进剂；溴化葡萄糖吡咯(溴化葡萄糖吡喀)(臭化グリコピロニウム)、丙谷胺(proglumide)、盐酸西曲酸酯(Cetraxate Hydrochloride)、西咪替丁(Cimetidine)及螺佐呋酮(spizofurone)等的消化性溃疡治疗剂；熊去氧胆酸及柳胺酚(osalmid)等的利胆剂；乌洛托品(Hexamine)、金雀花碱(Sparteine)、地诺前列素(dinoprost)及盐酸利托君(Ritodrine Hydrochloride)等的泌尿生殖器及肛门用剂；水杨酸、环吡酮胺(ciclopiroxolamine)(シクロピロクスオラミン)及盐酸氯康唑(Croconazole hydrochloride)(塩酸コロコナゾール)等的寄生性皮肤疾患用剂；脲等的皮肤软化剂；骨化三醇、盐酸硫胺素(Thiamine Hydrochloride)、核黄素磷酸钠(riboflavin sodium phosphate)、盐酸吡多辛(Pyridoxine Hydrochloride)、烟酰胺(nicotinic acid amide)、泛醇及抗坏血酸等的维生素剂；氯化钙、碘化钾及碘化钠等的无机物制剂；酚磺乙胺(Ethamsylate)等的止血剂；硫普罗宁(Tiopronin)等的肝脏疾患用剂；氰胺(Cyanamide)等的惯性性中毒用剂；秋水仙碱(Colchicine)、丙磺舒(Probenecid)及磺吡酮(Sulfinpyrazone)等的痛风治疗剂；甲苯磺丁脲、氯磺丙脲、格列嘧啶钠(glymidine sodium)、格列丁唑(glybuzole)、盐酸丁二胍(Buformin Hydrochloride)及胰岛素等的糖尿病用剂；苄基青霉素钾(benzylpenicillin potassium)、丙匹西林钾(propicillin potassium)、氯唑西林钠、氨苄西林钠、盐酸巴氨西林(BacampicillinHydrochloride)、羧苄西林钠(carbenicillin sodium)、头孢噻啶(Cephaloridine)、头孢西丁钠(Cefoxitin Sodium)、红霉素、氯霉素、四环素、硫酸卡那霉素及环丝氨酸等的抗生素；异腈、嗪酰胺及乙硫异烟胺等的化学疗法剂；盐酸吗啡、磷酸可待因(codeinephosphate)、盐酸可卡因(Cocaine Hydrochloride)、盐酸哌替啶(PethidineHydrochloride)及柠檬酸芬太尼(Fentanyl Citrate)等的麻醉药品。
若黏着剂层中含有高浓度的水杨酸甲酯及薄荷醇(例如，l-薄荷醇)，则通过这些药物的作用，黏着剂层变得容易可塑化的倾向会增强，贴剂的「硬度」会变弱，而使贴剂变得难以黏贴。然而，本实施方式的贴剂如上所述「硬度」强，因此，即使黏着剂层中高浓度包含这些的药物，贴剂也容易黏贴。尤其，在黏着剂层中包含以黏着剂层的总质量基准计为9～11质量％的水杨酸甲酯及2.5～6.5质量％或3～6质量％的薄荷醇的情况下，本实施方式的贴剂是适合的。
黏着剂层的厚度优选为50～3000μm。若黏着剂层的厚度为3000μm以下，则黏着剂层中所包含的药剂的释出性会成为良好，若为50μm以上，则皮肤接着性会成为良好，而贴剂不易剥离。
支持体的厚度为例如300μm以上，优选为400μm以上。若支持体的厚度为上述下限值以上，则不易产生黏着剂层的成分的渗出。或者，支持体的厚度为例如1200μm以下，优选为700μm以下。若支持体的厚度为上述上限值以下，则贴剂不易剥离。
支持体的厚度及黏着剂层的厚度的合计，也即贴剂的厚度优选为300～5000μm。若贴剂的厚度为5000μm以下，则贴剂的端部不易卡住衣类等，而贴剂不易剥离。若贴剂的厚度为300μm以上，则贴剂的支持性充分，而将贴剂确实地贴附，且，在贴附后的贴剂不易发生皱褶。
本实施方式的贴剂可为短边4～10cm且长边6～15cm的长方形或圆角长方形的形状。在本实施方式的贴剂的形状为长方形或圆角长方形的情况，优选长边方向及短边方向分别与水针(水针法(射流喷网成布法))无纺布的宽度方向及流向一致，且与贴剂的第1方向及第2方向一致。
本实施方式的贴剂也可进一步具备用以被覆黏着剂层进行保护的剥离薄膜。剥离薄膜的材质可列举：无延伸聚丙烯(无导向聚丙烯)(CPP)、延伸聚丙烯(导向聚丙烯)(OPP)、聚对苯二甲酸乙二酯(PET)、聚对苯二甲酸丁二酯(PBT)、聚乙烯、聚酯、聚氨酯(聚氨基甲酸乙酯,聚氨基甲酸酯)、聚氯乙烯及聚苯乙烯等的塑料薄膜、在合成树脂、合成纸及合成纤维等的硅加工而成的硅加工纸、铝箔、牛皮纸上层叠聚乙烯等而成的层叠加工纸等。于这些之中优选使用PET及加工纸。在贴剂具备剥离薄膜的情况，贴剂的刚软度(抗弯性，硬挺度)意味着，通过在剥离薄膜剥离后的状态的贴剂测定出的刚软度(抗弯性，硬挺度)。
剥离薄膜的厚度为例如10～100μm，优选为30～90μm，更优选为40～85μm。若剥离薄膜的厚度为上述下限值以上，则容易抓取剥离薄膜，且在将剥离薄膜剥离时不易缠住黏着剂层。另一方面，若剥离薄片的厚度为上述上限值以下，则制造时之切断变得容易，而制造适合性成为良好。
本实施方式的贴剂是可通过技术人员所周知的方法进行制造。例如，使用捏合机或混合器等的混合机，一边加热至120～160℃，一边将药物以外的黏着剂层的各成分进行混合，接着，以药物不进行热分解的温度进行添加混合，而调制黏着剂层形成用的混合物。可将此混合物直接于支持体上进行延展而形成黏着剂层，或者，于剥离薄膜上进行延展而形成黏着剂层，并于其上承载支持体，而使黏着剂层压着转移于支持体上。
实施例
贴剂的评估试验(1)
将表1的各成分进行加热及捏和而得到黏着剂1。于表2记载的聚酯制无纺布2～4，以使涂布量成为210g/m2的方式涂布黏着剂1，而得到实施例1～2及比较例1的贴剂。贴剂是短边的长度为约5cm，长边的长度为约7cm的长方形的形状。或者，无纺布的宽度方向与贴剂的长边方向为一致。针对所得到的贴剂进行下述的评估。将结果显示表4。
[表1]
黏着剂1 质量％
SIS 32.5
液体石蜡 27.5
聚异丁烯 3.0
萜烯树脂 17.0
水杨酸甲酯 10.0
l-薄荷醇 6.0
其他成分 4.0
合计 100
[表2]
[表3]
实施例1 实施例2 比较例1
支持体 无纺布2 无纺布3 无纺布4
黏着剂 黏着剂1 黏着剂1 黏着剂1
贴剂的评估项目
(1)贴剂的刚软度(抗弯性，硬挺度)
按照JIS L 1085：1998中规定的45°悬臂法，来测定贴剂的长边方向的刚软度(抗弯性，硬挺度)。
(2)贴剂的黏贴容易度
于健康的成人30名的肩部贴附贴剂，将黏贴容易度以下述3等级的基准而进行点数化，求出其平均值。将平均值未达2的情况的评估作为○，将2以上的情况之评估作为×。
1容易黏贴
2普通
3难以黏贴
(3)贴剂的附着性
于健康的成人30名的肩部贴附贴剂，将8小时后的贴剂的附着状态以下述之3等级的基准而进行点数化，求出其平均值。将平均值未达2的情况之评估作为○，将2以上的情况之评估作为×。
1贴剂完全未剥落，密着于皮肤的状态
2仅贴剂面的端部剥离的状态
3贴剂面的1/4以上剥离的状态
(4)贴剂的对于支持体的渗入(渗出)
目视观察贴剂的对于支持体的渗入(渗出)的有无，将无观察到渗入(渗出)的情况的评估作为○，将虽观察到些许渗入(渗出)但作为贴剂的使用并无问题的情况的评估作为Δ，将观察到渗入(渗出)而不适合作为贴剂使用的情况的评估作为×。
(5)制剂适合性
目视观察黏着剂层的表面的气泡的有无，将无气泡的情况的评估作为○，将有气泡的情况的评估作为×。
[表4]
如由表4所示额结果得以明确的是，贴剂的刚软度(抗弯性，硬挺度)为18以上的实施例1及2的贴剂是容易黏贴，附着性优异，并且未观察到对于支持体的黏着剂的渗入，而为优异的贴剂。另一方面，贴剂的刚软度(抗弯性，硬挺度)为未达18的比较例1的贴剂黏贴容易度方面差。
贴剂的评估试验(2)
将表5的各成分进行加热及捏和而得到黏着剂2～6。对于于表2记载的无纺布1(聚酯制)及3，以使涂布量成为210g/m2的方式涂布黏着剂2～6，而得到实施例3～7及比较例2～6的贴剂。针对所得到的贴剂进行与评估实验(1)相同的评估。将结果显示表7。
表5
黏着剂2 黏着剂3 黏着剂4 黏着剂5 黏着剂6
SIS 37.0 29.5 25.0 23.7 23.4
液体石蜡 18.9 17.9 23.7 23.7 27.2
聚异丁烯 10.0 6.9 12.0 7.8 7.8
萜烯树脂 5.0 25.0 20.0 21.5 18.5
水杨酸甲酯 10.0 10.0 10.0 10.0 10.0
l-薄荷醇 6.0 6.0 3.0 6.0 6.0
其他成分 13.1 4.7 6.3 7.3 7.1
成分合计 100 100 100 100 100
SIS：液体石蜡 1.96:1 1.65:1 1.05:1 1:1 0.86:1
(质量％)
[表6]
实施例3 实施例4 实施例5 实施例6 实施例7
支持体 无纺布3 无纺布3 无纺布3 无纺布3 无纺布3
黏着剂 黏着剂2 黏着剂3 黏着剂4 黏着剂5 黏着剂6
比较例2 比较例3 比较例4 比较例5 比较例6
支持体 无纺布1 无纺布1 无纺布1 无纺布1 无纺布1
黏着剂 黏着剂2 黏着剂3 黏着剂4 黏着剂5 黏着剂6
[表7]
如由表7所示的结果得以明确的是，使用通过针刺法所制造的无纺布1作为支持体的比较例2～6的贴剂在黏贴容易度方面差。另一方面，使用通过水针(水针法(射流喷网成布法))法所制造的无纺布3作为支持体的实施例3～7的贴剂是黏贴容易度及附着性优异。且，SIS与液体石蜡的质量比为1～1.65：1的范围的实施例4～6的贴剂是在对于支持体之黏着剂的渗入难度及制造适合性方面皆优异。

Claims (12)

1.一种贴剂，其是具有支持体和层叠于支持体上的黏着剂层的贴剂，
支持体包含射流喷网成布法无纺布或由射流喷网成布法无纺布所构成，
黏着剂层包含苯乙烯-异戊二烯-苯乙烯嵌段共聚物及液体石蜡，
贴剂具有作为规定的基准轴方向的第1方向，与和第1方向成直角的第2方向，
以JIS L 1085：1998中规定的45°悬臂法测定的贴剂的第1方向的硬挺度为18～30mm。
2.权利要求1中记载的贴剂，其中，黏着剂层中的苯乙烯-异戊二烯-苯乙烯嵌段共聚物与液体石蜡的质量比为1～1.65：1。
3.权利要求2中记载的贴剂，其中，黏着剂层包含水杨酸甲酯及薄荷醇。
4.权利要求3中记载的贴剂，其中，黏着剂层包含聚异丁烯。
5.权利要求4中记载的贴剂，其中，黏着剂层包含萜烯树脂。
6.权利要求5中记载的贴剂，其中，黏着剂层以黏着剂层的总质量为基准计，包含9～11质量％的水杨酸甲酯及2.5～6.5质量％的薄荷醇。
7.权利要求5中记载的贴剂，其中，黏着剂层以黏着剂层的总质量为基准计，包含23.7～32.5质量％的苯乙烯-异戊二烯-苯乙烯嵌段共聚物、17.9～27.5质量％的液体石蜡、9～11质量％的水杨酸甲酯、3～6质量％的薄荷醇、3～12质量％的聚异丁烯及17～25质量％的萜烯树脂。
8.权利要求1～7中任一项中记载的贴剂，其中，无纺布的单位面积重量为90～110g/m2。
9.权利要求1～8中任一项中记载的贴剂，其中，无纺布的宽度方向的20％模量为3～5N/50mm。
10.权利要求1～9中任一项中记载的贴剂，其中，无纺布的宽度方向的50％模量为8～15N/50mm。
11.权利要求1～10中任一项中记载的贴剂，其中，无纺布包含聚酯或由聚酯所构成。
12.权利要求1～11中任一项中记载的贴剂，其中，以JIS L 1085：1998中规定的45°悬臂法测定的贴剂的第1方向的硬挺度为18～27mm。
CN201680008513.4A 2015-02-05 2016-02-05 贴剂 Active CN107205957B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015021411A JP5767417B1 (ja) 2015-02-05 2015-02-05 貼付剤
JP2015-021411 2015-02-05
PCT/JP2016/053456 WO2016125878A1 (ja) 2015-02-05 2016-02-05 貼付剤

Publications (2)

Publication Number Publication Date
CN107205957A true CN107205957A (zh) 2017-09-26
CN107205957B CN107205957B (zh) 2020-12-01

Family

ID=53888058

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680008513.4A Active CN107205957B (zh) 2015-02-05 2016-02-05 贴剂

Country Status (10)

Country Link
US (1) US10292941B2 (zh)
EP (1) EP3254677B1 (zh)
JP (1) JP5767417B1 (zh)
KR (1) KR101939932B1 (zh)
CN (1) CN107205957B (zh)
BR (1) BR112017015737B1 (zh)
ES (1) ES2887200T3 (zh)
HK (1) HK1245121A1 (zh)
TW (1) TWI674115B (zh)
WO (1) WO2016125878A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5767417B1 (ja) 2015-02-05 2015-08-19 久光製薬株式会社 貼付剤
CN107847357A (zh) * 2015-05-20 2018-03-27 日绊株式会社 贴附材料、以及贴附材料中使用的贴附材料用支承体
JP2021083934A (ja) * 2019-11-29 2021-06-03 リバテープ製薬株式会社 両伸縮パッド及び該両伸縮パッドを用いた創傷保護材

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09124463A (ja) * 1995-10-31 1997-05-13 Nitto Denko Corp 貼付剤
CN1430507A (zh) * 2000-05-19 2003-07-16 久光制药株式会社 贴剂

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0611698B2 (ja) * 1984-12-19 1994-02-16 大正製薬株式会社 貼付剤
JPH07215847A (ja) * 1994-02-04 1995-08-15 Sekisui Chem Co Ltd 眠気防止用テープ
JPH09143059A (ja) * 1995-11-27 1997-06-03 Japan Vilene Co Ltd 皮膚貼付剤
US6620430B2 (en) 1996-12-06 2003-09-16 Hisamitsu Pharmaceutical Co., Inc. Plaster containing felbinac
JP3438814B2 (ja) 2000-02-29 2003-08-18 節 李 粉薬の楽飲み
US20030149383A1 (en) * 2000-04-18 2003-08-07 Yasuhiro Ikeura Patch containing anti-inflammatory agent
JP4820495B2 (ja) * 2001-05-29 2011-11-24 株式会社トクホン プラスター剤
JP4295488B2 (ja) * 2002-10-22 2009-07-15 日東電工株式会社 経皮吸収型貼付製剤
JPWO2006006655A1 (ja) * 2004-07-14 2008-05-01 マイコール株式会社 発熱パッド及びその使用方法
AU2006221389B2 (en) * 2005-03-10 2011-04-28 Hisamitsu Pharmaceutical Co., Inc. Adhesive and adhesive patch
JP4939113B2 (ja) * 2005-06-01 2012-05-23 ニプロパッチ株式会社 貼付剤
JP4592516B2 (ja) * 2005-06-29 2010-12-01 ダイワボウホールディングス株式会社 液体含浸用皮膚被覆シートおよびその製造方法、ならびにそれを用いたフェイスマスク
EP2399607B1 (en) * 2009-02-18 2017-11-29 Hisamitsu Pharmaceutical Co., Inc. Transdermal preparation
JP5318639B2 (ja) * 2009-04-08 2013-10-16 株式会社ウェーブロック・アドバンスト・テクノロジー 貼付剤用支持体、及び、貼付剤
WO2011046023A1 (ja) * 2009-10-14 2011-04-21 久光製薬株式会社 貼付剤を製造するための方法及び装置
JP2013184977A (ja) * 2012-03-07 2013-09-19 Km Transderm Ltd 貼付剤
JP5767417B1 (ja) 2015-02-05 2015-08-19 久光製薬株式会社 貼付剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09124463A (ja) * 1995-10-31 1997-05-13 Nitto Denko Corp 貼付剤
CN1430507A (zh) * 2000-05-19 2003-07-16 久光制药株式会社 贴剂

Also Published As

Publication number Publication date
JP5767417B1 (ja) 2015-08-19
WO2016125878A1 (ja) 2016-08-11
BR112017015737A2 (pt) 2018-03-13
TW201636009A (zh) 2016-10-16
EP3254677A4 (en) 2018-09-19
US20180015049A1 (en) 2018-01-18
EP3254677B1 (en) 2021-08-04
KR20170109039A (ko) 2017-09-27
KR101939932B1 (ko) 2019-01-17
US10292941B2 (en) 2019-05-21
ES2887200T3 (es) 2021-12-22
BR112017015737B1 (pt) 2023-01-17
CN107205957B (zh) 2020-12-01
HK1245121A1 (zh) 2018-08-24
EP3254677A1 (en) 2017-12-13
TWI674115B (zh) 2019-10-11
JP2016141675A (ja) 2016-08-08

Similar Documents

Publication Publication Date Title
US20200046963A1 (en) System for the Transdermal Delivery of Active Ingredient
WO2003037393A1 (fr) Emplatre a support lamine
JP5711743B2 (ja) 医療用貼付剤
TW201124174A (en) Pharmaceutical composition for external application
WO2001087275A1 (en) Plaster
TW200306870A (en) Sheet shape epithemic agent
JP5711742B2 (ja) 医療用貼付剤
TWI341735B (en) Adhesive preparations
JP6014813B2 (ja) 経皮吸収製剤および皮膚貼付用粘着シート
JP3699527B2 (ja) テープ製剤
CN107205957A (zh) 贴剂
TW201223562A (en) Transdermal absorption preparation
WO2003103641A1 (ja) 貼付剤
US20090238860A1 (en) Adhesive Patch Less Irritative to Skin
CN108778272A (zh) 经皮吸收制剂
JP5064234B2 (ja) 粘着基剤および経皮吸収型貼付剤
JP5586888B2 (ja) 非含水貼付製剤
ES2385737T3 (es) Fármaco para uso externo y parche adhesivo
JP6912122B2 (ja) 経皮投与製剤
TW201605498A (zh) 含有可樂寧之貼劑
JP2014125483A (ja) 貼付剤
JP2006225319A (ja) 貼付製剤
JPH08104622A (ja) 支持体及びそれを用いた外用貼付剤
TW201521795A (zh) 經皮吸收製劑

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1240505

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant