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CN107158029A - A kind of skin care solution - Google Patents

A kind of skin care solution Download PDF

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Publication number
CN107158029A
CN107158029A CN201710419379.3A CN201710419379A CN107158029A CN 107158029 A CN107158029 A CN 107158029A CN 201710419379 A CN201710419379 A CN 201710419379A CN 107158029 A CN107158029 A CN 107158029A
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CN
China
Prior art keywords
skin care
care solution
skin
copper
zinc
Prior art date
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Pending
Application number
CN201710419379.3A
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Chinese (zh)
Inventor
孙军
窦伟
张淑瑜
赵普军
毕云生
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Individual
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Individual
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Priority to CN201710419379.3A priority Critical patent/CN107158029A/en
Publication of CN107158029A publication Critical patent/CN107158029A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides a kind of skin care solution, including following component：The 100mg/L of selenium-containing compound 0.1 (in terms of selenium), the 1500mg/L of copper-containing compound 50 (in terms of copper), the mg/L of zinc compound 50 2000 (in terms of zinc) and solvent.Present invention also offers application of the above-mentioned skin care solution in treatment dandruff or the anti-dandruff daily chemical products of the excessive external used medicine of body scurf and head are prepared.The skin care solution of the present invention, trace element supplemented with local skin tissue, improves local cutin formation and promotes cell synthesis SOD enzymes there is provided reproducibility microenvironment, the ability that local skin tackles oxidative stress is improved, promotes the collage synthesis function of local skin tissue.Solve the problem of long-term use washing product containing EDTA causes local skin nutrient imbalance.The skin care solution material of the present invention is easy to get, cost is low, and effect is good, and the scurf that can be effectively improved local skin such as increases at the abnormality, can be widely applied in the anti-dandruff daily chemical products in head.

Description

A kind of skin care solution
Technical field
The present invention relates to a kind of skin care solution, belong to field of daily chemicals.
Background technology
Dandruff increases（Dandruff）It is common skin of head dysfunction.So far, scurf increases definite Pathogenesis is not yet illustrated, it is considered that dandruff increase be multifactor functioning result, risk factor includes：Horse traction color Bacterium（Malassezia）Propagation, smegma is hyperfunction and private medical service.Wherein private medical service includes：Epidermal barrier it is complete Whole property, immune response, neural emotion and trophic factor etc..Although may separate out chlosma in scurf（M.globosaWithM. restricta）, and accumulative evidence supports the hyper-proliferative of the bacterium to be one of key factor that scurf increases, but simultaneously can be with Certainly be：The participation of other conditions is indispensable.In recent years, the role of skin-nourishing unbalance factor is increasingly subject to pay attention to, Achievement in research increasingly increases.
Selenium（Selenium）One of trace element necessary to be humans and animals, selenium constitutes selenoprotein after entering human body.Selenium egg It is the final form that selenium element realizes its human body physiological function in vain, selenoprotein depth participates in maintaining the normal of each organ-tissue of human body Physiological function, including skin.SOD enzymes in human body are mainly Cu/Zn-SOD hypotypes, research show copper, the content of zinc with Corresponding SOD enzyme activity height correlation；And GPx1（Glutathione peroxidase）Activity then with internal Se content height phase Close.Human body selenium deficiency causes GPx1 activity decrease, tackles oxidative stress reduced capability；Also result in Selenonic protein enzyme --- D3 Enzyme（Iodothyronine deiodinase D3）Activity decrease, causes KCs cells（Hepatic macrophages）Interior T3（Triiodo thyroid gland Former propylhomoserin）Level rises, and induces KCs Proliferation, Differentiations and adhesion function is abnormal, ultimately result in skin barrier function decline, further Aggravate the oxidative stress status of local skin.If now human body SOD enzyme activity is not enough（Zinc or copper lack）, it is difficult to reply increases severely Oxidative stress pressure, then local skin the dysfunction state that typical scurf increases can be presented.
Debris removing hair washing product is main to add ZPT as main flow in the market --- pass through antimycotic and supplement Zn-ef ficiency is effect means.It is single that existing product does not only exist mechanism of action, and often with the common prescriptions of EDTA, have a strong impact on it and dispel Consider effect to be worth doing, or even have the opposite effect.Therefore, development can correct local skin micro-element nutrition imbalance state, various dimensions reply Dandruff increases the new care product of mechanism, not the only social demand of reality, and there is potential commercial value.
The content of the invention
Cause local skin nutrient imbalance, current debris removing daily chemical products debris removing to solve to be used for a long time washing product containing EDTA Effect is poor, the problem of easily recur, and the skin care solution of skin-nourishing imbalance state is improved the invention provides a kind of.
It is excessive in preparation treatment dandruff or body scurf it is a further object of the present invention to provide a kind of above-mentioned skin care solution External used medicine and hair washing daily chemical products in application.
To achieve the above object, the present invention is adopted the following technical scheme that.
A kind of skin care solution, including following component：Selenium-containing compound 0.1-100 mg/L（In terms of selenium）, copper-containing compound 50-1500 mg/L（In terms of copper）, zinc compound 50-2000 mg/L（In terms of zinc）And solvent.
Preferably, in the skin care solution, selenium-containing compound 5-50 mg/L（In terms of selenium）, copper-containing compound 100- 1000 mg/L（In terms of copper）, zinc compound 200-2000 mg/L（In terms of zinc）.
The selenium-containing compound, including inorganic selenium and organic selenium compounds, selected from sodium selenite, potassium selenite and One or more in seleno-amino acids and its derivative.
The copper-containing compound, the one or more in copper gluconate, copper chloride and copper sulphate.
The zinc compound, one kind or one kind in glucose saccharic acid zinc, ZPT, zinc chloride and zinc sulfate More than.
One or more of the solvent in alcohols, esters, ethers and water.
The skin care solution, in addition to following component：Antioxidant 0.1-50 g/L, preferably 1-10 g/L；Moisturizing Agent 1-50 g/L.
The antioxidant is selected from natural animal-plant extract, ascorbic acid and its derivative, vitamin E and its derivative Thing, ubiquinone10, one or more in alpha-lipoic acid and antioxidase preparation.
The NMF be selected from urea, allantoin and its derivative, panthenol, biological polyoses class, collagen, amino acid and One or more in its derivative and polyalcohol.
The preservative is selected from parabens, isothiazolinone, benzoic acid and its derivative, imidazolidinyl Ureas, sorbic acid and its salt, phenoxetol, cis- 1-（Chlorallylene base）Azepine -1- nitrogen adamantane the chlorinations of -3,5,7- three One or more in thing and quaternary ammonium salt -15.
The skin care solution also includes spices, surfactant, colouring agent, viscosity modifier, osmotic pressure regulator, angle Matter softening agent and pH adjusting agent.
The skin care solution, without metal-chelator.
A kind of application of above-mentioned skin care solution in treatment dandruff or the excessive external used medicine of body scurf is prepared.
A kind of application of above-mentioned skin care solution in the anti-dandruff daily chemical products in head.
The trace elements of selenium that the skin care solution of the present invention, wherein selenium-containing compound are used to supplement local skin tissue is needed Ask, improve local keratinocyte proliferation and differentiation function；Copper-containing compound is used to supplement local skin with zinc compound The trace copper and zinc demand of tissue, promote cell synthesis SOD enzymes, improve the ability that local skin tackles oxidative stress；It is anti- Oxidant is used for one reproducibility microenvironment of structure in local skin tissue, reduces the oxidative stress pressure of local skin, together When promote local skin tissue collage synthesis function；NMF and osmotic pressure regulator are used to improve oozing for local skin tissue Pressure, reaches the function of moisturizing thoroughly, promotes the nutrients such as selenium, copper, zinc to penetrate into skin, while it is different also to soften local skin Normal cuticula；Biological polyoses class, collagen class and polyalcohols composition not only have moisture-keeping function, also viscous with regulation Degree, the effect of osmotic pressure.
The present invention has advantages below：The skin care solution material of the present invention is easy to get, cost is low, and effect is good, can be effective The scurf for improving skin especially skin of head such as increases at the abnormality, can be widely applied in the anti-dandruff daily chemical products in head.
Embodiment
With reference to embodiment, the present invention will be further described, but the present invention is not limited by following embodiments.
Embodiment 1
Skin care solution uses formula as below：
The mg of selenomethionine 11.8
The g of copper gluconate 0.73
The g of zinc gluconate 1.40
The g of vitamin C glucoside 1.00
Retinol Palmitate 1.50g
Allantoin 17.0g
Pyrrolidone sodium carboxylate 3.00g
The g of phenoxetol 0.30
The g of methyl-isothiazol 0.05
The mL of glycerine 5.0
The mL of 1,3 butylene glycol 10.0
Water is mended to 1000mL.
Compound method is as follows：
（1）Weigh selenomethionine, copper gluconate, zinc gluconate, vitamin C glucoside, Retinol Palmitate, Allantoin, pyrrolidone sodium carboxylate, phenoxetol, methyl-isothiazol 800mL water dissolve；
（2）Glycerine, 1,3 butylene glycol are added into above-mentioned steps（1）Solution in, add water to 1000mL, produce skin of head nursing Liquid.
Embodiment 2
Skin of head conditioning liquid uses formula as below：
Selenocysteine 16.8mg
The g of copper chloride 0.61
Zinc gluconate 4.10g
It is esterified vitamin C 5.00g
Puridoxine hydrochloride 1.00g
Panthenol 10.0g
Magnesium chloride 0.18g
Magnesium nitrate 0.32g
The g of methyl chloroisothiazole 0.15
The g of methyl-isothiazol 0.05
Polyethylene glycol 400 20.0mL
Water is mended to 1000mL.
Compound method is as follows：
（1）Weigh selenocysteine, copper chloride, zinc gluconate, esterification vitamin C, puridoxine hydrochloride, panthenol, magnesium chloride, Magnesium nitrate, methyl chloroisothiazole and with 800mL water dissolve；
（2）Polyethylene glycol 400 is added into above-mentioned steps（1）Solution in, add water to 1000mL, produce skin of head conditioning liquid.
Embodiment 3
Skin of head conditioning liquid uses formula as below：
The mg of sodium selenite 22.8
The g of copper gluconate 1.50
The g of zinc gluconate 3.00
The g of VCE 2.00
Urea 30.0g
Magnesium chloride 0.18g
Magnesium nitrate 0.42g
The g of methyl chloroisothiazole 0.15
The g of methyl-isothiazol 0.05
The mL of glycerine 5.0
The mL of 1,2- propane diols 10.0
Water is mended to 1000mL.
Compound method is as follows：
（1）Weigh sodium selenite, copper gluconate, zinc gluconate, VCE, urea, magnesium chloride, magnesium nitrate, first Base chloroisothiazole, methyl-isothiazol 800mL water dissolve；
（2）Glycerine, 1,2- propane diols, preservative liquid are added into above-mentioned steps（1）Solution in, add water to 1000mL, produce head Portion's skin care solution.
Embodiment 4
Skin of head conditioning liquid uses formula as below：
L- selenium-methyl selenium substituted aminothiopropionics 54.6mg
Copper gluconate 3.63g
Zinc sulfate 1.45g
Co-Q10 0.50g
The mL of pomegranate extract solution 6.5
Glycine betaine 5.0g
Collagen protein powder 10.0g
Methyl hydroxybenzoate 0.70g
Propylben 0.50g
Phenoxetol 0.30g
Xanthans 0.50g
Ethanol 30.0mL
Water is mended to 1000mL.
Compound method is as follows：
（1）Weigh L- selenium-methyl selenium substituted aminothiopropionics, copper gluconate, zinc sulfate, pomegranate extract solution, glycine betaine, collagen Powder 800mL water dissolves；
（2）By ubiquinone10, methyl hydroxybenzoate, propylben, phenoxetol, xanthans ethanol dissolve after with step（1） Solution mixing, add water to 1000mL, produce skin of head conditioning liquid.
Embodiment 5
Skin of head conditioning liquid uses formula as below：
Selenocysteine 100.8mg
Sulfuric acid acid copper 2.47g
ZPT 4.76g
Vitamin C glucoside 8.00g
SOD enzymes 2.00g
Hyaluronic acid 10.0g
The g of phenoxetol 0.20
Methyl-isothiazol 0.05g
The mL of ethanol 15.0
Water is mended to 1000mL.
Compound method is as follows：
（1）Weigh sodium selenite, copper gluconate, zinc gluconate, VCE, urea, magnesium chloride, magnesium nitrate, first Base chloroisothiazole, methyl-isothiazol 800mL water dissolve；
（2）Glycerine, 1,2- propane diols are added into above-mentioned steps（1）Solution in, add water to 1000mL, produce skin of head nursing Liquid.
The compliance test result of the skin of head conditioning liquid of embodiment 6
The volunteer for participating in experiment is certain working unit personnel, there is skin of head symptom.Test group 12, control group 8. Main header skin symptom is as follows：Long-term existence dandruff increases, and with dry scalp or the vigorous phenomenon of smegma, occasionally has Pruritis；Local inflammation focus is rare.
2.1 application method
Test group uses skin of head conditioning liquid in embodiment 3 as follows, continues 21 days.
（1）Stop using the washing product containing EDTA and its salt or his metal-chelator；
（2）Overhead skin is squirted using this product once, every time 2.5 mL or so daily（General 20-25 is pressed）, by head skin Skin is uniformly squirted as standard, is dried naturally；
（3）Hair washing is finished every time, is wiped and is used this product after dry hair immediately.
Control group localized pulverization uses the control sample being made up of pure water, uses 21 days.
2.2 using effects are evaluated
The using effect of skin of head conditioning liquid is evaluated according to following evaluation criteria, using effect data are shown in Table 1.
（1）Syndrome Scale and skin of head conditioning liquid effective evaluation standard
Syndrome Scale quantitative criteria
The skin of head Syndrome Scale standard of table 1
Skin of head conditioning liquid using effect evaluation criteria
Comprehensive therapeutic effect index=[（Integrated before treatment after integration-treatment）Integrated before ÷ treatments] × 100%.
Recovery from illness：Symptom disappears after medication, and integrated value reduces >=95%.
It is effective：Symptom is obviously improved after medication, and integrated value reduces >=70%.
Take a turn for the better：Symptom improves after medication, and integrated value reduces >=30%.
It is invalid：Symptom is not improved after medication, or integrated value reduces ＜ 30%.
Recovery from illness will finally be counted as " effective " with effective.
（2）Skin of head conditioning liquid using effect
All volunteers for participating in this experiment complete using effect experience, and test data is as follows：
The skin of head conditioning liquid antidandruff efficacy of table 2
According to the data of table 2, skin of head conditioning liquid of the invention uses 14 days effective percentage to be 68.75%, and effective percentage is within 21 days 87.50%, compared with blank control, there is conspicuousness in difference（P<0.05, Wilcoxon rank sum test）And experimental period Between do not occur adverse reaction.Test data shows that skin of head conditioning liquid of the invention can be effectively improved the skin of skin of head Bits such as increase at the abnormality.

Claims (8)

1. a kind of skin care solution, it is characterised in that including following component：Selenium-containing compound 0.1-100 mg/L（In terms of selenium）, Copper-containing compound 50-1500 mg/L（In terms of copper）, zinc compound 50-2000 mg/L（In terms of zinc）And solvent.
2. skin care solution according to claim 1, it is characterised in that the selenium-containing compound, including inorganic selenium chemical combination Thing and organic selenium compounds, one kind in sodium selenite, potassium selenite and seleno-amino acids and its derivative or it is a kind of with On；
The copper-containing compound, the one or more in copper gluconate, copper chloride and copper sulphate；
The zinc compound, one kind in glucose saccharic acid zinc, ZPT, zinc chloride and zinc sulfate or it is a kind of with On；
One or more of the solvent in alcohols, esters, ethers and water.
3. skin care solution according to claim 1, it is characterised in that also including following component：Antioxidant 0.1-50 G/L, NMF 1-50 g/L and preservative.
4. skin care solution according to claim 3, it is characterised in that the antioxidant is extracted selected from natural animal-plant Thing, ascorbic acid and its derivative, vitamin E and its derivative, ubiquinone10, one kind in alpha-lipoic acid and antioxidase preparation Or more than one；
The NMF is selected from urea, allantoin and its derivative, panthenol, biological polyoses class, collagen, amino acid and its spread out One or more in biological and polyalcohol；
The preservative is selected from parabens, isothiazolinone, benzoic acid and its derivative, imidazolidinyl urea Class, sorbic acid and its salt, phenoxetol, cis- 1-（Chlorallylene base）Azepine -1- nitrogen adamantane the chlorides of -3,5,7- three With the one or more in quaternary ammonium salt -15.
5. according to any described skin care solution of claim 1 or 3, it is characterised in that also including spices, surfactant, Colouring agent, viscosity modifier, osmotic pressure regulator, keratolytic, pH adjusting agent.
6. according to any described skin care solution in claim 1,3 or 5, it is characterised in that without metal-chelator.
7. a kind of skin care solution as described in claim 1-6 is any is preparing treatment dandruff or the excessive external application of body scurf Application in medicine.
8. a kind of application of skin care solution as described in claim 1-6 is any in the anti-dandruff daily chemical products in head.
CN201710419379.3A 2017-06-06 2017-06-06 A kind of skin care solution Pending CN107158029A (en)

Priority Applications (1)

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Application Number Priority Date Filing Date Title
CN201710419379.3A CN107158029A (en) 2017-06-06 2017-06-06 A kind of skin care solution

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Publication Number Publication Date
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110893171A (en) * 2019-12-30 2020-03-20 济源市万洋华康生物科技有限公司 Preparation method of composition for inhibiting wound cicatricial healing
CN114848522A (en) * 2022-05-24 2022-08-05 华南农业大学 Application of selenomethionine in preparation of skin care product
CN115040446A (en) * 2022-06-24 2022-09-13 曾会明 SOD plant extract skin care composition, skin care product and preparation method thereof
FR3144756A1 (en) * 2023-01-09 2024-07-12 L'oreal SCALP CARE COMPOSITION COMPRISING A LIPOPHILIC SOLID ACTIVE AGENT, A MONOALCOHOL AND A HYDROPHILIC THICKENER

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JPS61233608A (en) * 1985-04-10 1986-10-17 Shiseido Co Ltd Hair cosmetic
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CN103735421A (en) * 2013-12-24 2014-04-23 董延昌 Anti-skin-aging composition and preparation method thereof

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110893171A (en) * 2019-12-30 2020-03-20 济源市万洋华康生物科技有限公司 Preparation method of composition for inhibiting wound cicatricial healing
CN110893171B (en) * 2019-12-30 2021-07-27 河南希百康健康产业有限公司 Preparation method of composition for inhibiting wound cicatricial healing
CN114848522A (en) * 2022-05-24 2022-08-05 华南农业大学 Application of selenomethionine in preparation of skin care product
CN115040446A (en) * 2022-06-24 2022-09-13 曾会明 SOD plant extract skin care composition, skin care product and preparation method thereof
FR3144756A1 (en) * 2023-01-09 2024-07-12 L'oreal SCALP CARE COMPOSITION COMPRISING A LIPOPHILIC SOLID ACTIVE AGENT, A MONOALCOHOL AND A HYDROPHILIC THICKENER

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Application publication date: 20170915