CN107157788A - A kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing - Google Patents
A kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing Download PDFInfo
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- CN107157788A CN107157788A CN201710314056.8A CN201710314056A CN107157788A CN 107157788 A CN107157788 A CN 107157788A CN 201710314056 A CN201710314056 A CN 201710314056A CN 107157788 A CN107157788 A CN 107157788A
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- Prior art keywords
- liposome
- suncream
- phases
- sun
- thing
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- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 47
- 239000002502 liposome Substances 0.000 title claims abstract description 18
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 title claims abstract description 15
- 229960001679 octinoxate Drugs 0.000 title claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 16
- 238000004945 emulsification Methods 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 229930182478 glucoside Natural products 0.000 claims abstract description 5
- 150000008131 glucosides Chemical class 0.000 claims abstract description 5
- 239000000413 hydrolysate Substances 0.000 claims abstract description 5
- 235000010447 xylitol Nutrition 0.000 claims abstract description 5
- 238000003556 assay Methods 0.000 claims abstract description 4
- 238000000265 homogenisation Methods 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000004475 Arginine Substances 0.000 claims abstract description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 3
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical compound C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229960000601 octocrylene Drugs 0.000 claims abstract description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- -1 Triethoxy octyl group Chemical group 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000004408 titanium dioxide Substances 0.000 claims description 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 2
- KZVAAIRBJJYZOW-VPENINKCSA-N (2r,3r,4s)-2-(hydroxymethyl)oxolane-3,4-diol Chemical compound OC[C@H]1OC[C@H](O)[C@H]1O KZVAAIRBJJYZOW-VPENINKCSA-N 0.000 claims description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 2
- 229940083987 anhydroxylitol Drugs 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- 229940036350 bisabolol Drugs 0.000 claims description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 2
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
- 229940085262 cetyl dimethicone Drugs 0.000 claims description 2
- JDRSMPFHFNXQRB-IBEHDNSVSA-N decyl glucoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JDRSMPFHFNXQRB-IBEHDNSVSA-N 0.000 claims description 2
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims description 2
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 2
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 claims description 2
- 229960000655 ensulizole Drugs 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- SMITZRKODWNNBA-UHFFFAOYSA-N hexadecyl dihydrogen phosphate;potassium Chemical compound [K].CCCCCCCCCCCCCCCCOP(O)(O)=O SMITZRKODWNNBA-UHFFFAOYSA-N 0.000 claims description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
- 229940101267 panthenol Drugs 0.000 claims description 2
- 235000020957 pantothenol Nutrition 0.000 claims description 2
- 239000011619 pantothenol Substances 0.000 claims description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 2
- 229940113124 polysorbate 60 Drugs 0.000 claims description 2
- 229940078492 ppg-17 Drugs 0.000 claims description 2
- 229910000077 silane Inorganic materials 0.000 claims description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
- 229940042585 tocopherol acetate Drugs 0.000 claims description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims 1
- 229920001206 natural gum Polymers 0.000 claims 1
- 230000000475 sunscreen effect Effects 0.000 abstract description 12
- 239000000047 product Substances 0.000 abstract description 5
- 230000001965 increasing effect Effects 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 230000009931 harmful effect Effects 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 description 7
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 206010042496 Sunburn Diseases 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 241000220479 Acacia Species 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000872198 Serjania polyphylla Species 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 241000863032 Trieres Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to daily cosmetics technical field, it is related to a kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing, is that pearl hydrolysate liposome, Magnesiumaluminumsilicate, arginine, pure water etc. are added in emulsification pot, heating, homogeneous；Ethylhexyl methoxy cinnamate liposome thing, cocoyl glucoside, Octocrilene etc. are added in oil cauldron, it is pumped into after heating in emulsification pot, high speed homogenization, 55~60 DEG C of addition Plantacare 818s, anhydro xylitols etc. are cooled to stir, it is cooled to 28~35 DEG C of addition essence, stir, physical and chemical index after the assay was approved, discharges.Chemical sun is combined by the present invention with physical sunscreen agent, solve the harmful effect of existing physical sunscreen and chemical sunscreen, sun-proof result can not only be reached, and the security of product can be increased, reduce excitant, the growing sun-proof demand of consumer is met, is sun-proof good merchantable brand of a summer with stronger security.
Description
Technical field
The invention belongs to daily cosmetics technical field, it is related to a kind of suncream and preparation method thereof, is specifically a kind of addition
Ethylhexyl methoxy cinnamate liposome suncream and preparation method.
Background technology
In modern society, with the popularization of popular science knowledge, the enhancing of people's health care consciousness, increasing people will appreciate that
The injury that ultraviolet irradiates to skin is irreversible, and it not only can also form light aging, skin with tanned, sunburn skin
Skin cancer etc., with the improvement of living standards with the enhancing of sun-proof consciousness, suncream has the larger market space, how to accomplish both
It is effectively and safe, it is the target of researcher's long-sought.
At present, sun-proof mainly to have physical sunscreen and chemical sunscreen, physical sunscreen is by adding titanium dioxide and zinc oxide
Deng powder, using optical principle is by ultraviolet reflection and shines away, sun-proof purpose is reached, the weakness of simple physical sunscreen
Be addition titanium dioxide reach it is a certain amount of after can skin formation " bloom ", titanium dioxide is floated on skin during perspiration, so that shadow
Personal image is rung, and the use feeling of product can be reduced after zinc oxide addition.Chemical sunscreen is to ultraviolet by chemical sun
Luminous energy conversion reach sun-proof result, but chemical sun is applied to after being absorbed by the body on skin, easily causes allergy.
The content of the invention
It is an object of the invention to provide a kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing, solution
The harmful effect of certainly existing physical sunscreen and chemical sunscreen, by liposome technology, by the larger sun-screening agent of addition into
Divide ethylhexyl methoxy cinnamate chemical sun to be wrapped up, sun-proof result can not only be reached, and product can be increased
Security, reduce excitant, meet the growing sun-proof demand of consumer, and with stronger security.
The technical solution adopted in the present invention：
A kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing, contains following percentage by weight group
Point：
A phases
Cocoyl glucoside 1.5~4.0%
Cetostearyl alcohol 2~4.0%
Phosphoric acid monohexadecyl ester potassium 0.5~1.0%
Carbonic acid dioctyl ester 5~8%
Ethylhexyl methoxy cinnamate liposome thing (water, ethylhexyl methoxy cinnamate, silica, polyethylene
Adjoin network alkanone, Phenoxyethanol, Chlorphenesin, EDTA-2Na, Butylated Hydroxytoluene) 5~8%
Titanium dioxide 2~4%
Silica 0.06~0.12%
Triethoxy octyl group silane 0.2~0.4%
Uvinul A Plus 1~3%
Octocrilene 2~4%
Diethylhexyl Butamido Triazon 0.8~2%
Tocopherol acetate 0.5~2%
Caprylic/capric triglyceride 2~4%
Cetyl dimethicone 1~3%
B phases
Butanediol 5~10%
Pearl hydrolysate liposome 5~10%
Acacia (ACACIA SENEGAL) glue 0.2~0.4%
Xanthans 0.2~0.4%
Magnesiumaluminumsilicate 0.2~0.4%
Glycine betaine 2~4%
Phenylbenzimidazolesulfonic acid 2.0~4%
Arginine 1.2~2%
EDTA-2Na 0.05~0.15%
Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers 0.8~2%
Saualane 0.2~0.4%
Polysorbate -60 0.03~0.05%
The smooth isostearate 0.015~0.03% of sorb
Pure water to 100%
C phases
MBBT 2~4%
Plantacare 818 0.8~2%
Xylitol-based glucoside 0.2~0.8%
Anhydro xylitol 0.1~0.5%
Xylitol 0.15~0.3%
Glucose 0.05~0.1%
Bisabolol 0.16~0.3%
Fanesol 0.04~0.08%
Panthenol 0.4~1.5%
PEG/PPG-17/6 copolymer 1 .5~2.5%
D phases
Essence 0.05~0.2%.
Pearl hydrolysate liposome of the present invention is prepared according to the method for patent " CN1795874A ".The pearl
Hydrolysate liposome can reduce the conductance of hydrolyzate, reduce the destruction to cosmetics series, effectively protect having for pearl
Effect composition is not destroyed by other components, substantially increases the assimilation effect of pearl nutritional composition, it is possible to use hydrolyzed pearl solution
Several amino acids and trace element in liposome, promote neonatal cell to synthesize, the dismutase (SOD) in promotion human skin
Activity, suppresses the formation of melanin, reaches the effect of bright color.
The preparation method of suncream provided by the present invention, its step is as follows：
1st, B is added in emulsification pot, is heated to 80~85 DEG C, low speed homogeneous 2~5 minutes is incubated 25~40 minutes.
2nd, A is added in oil cauldron, is heated to 80~85 DEG C, be incubated 25~40 minutes.
3rd, A phases are pumped into emulsification pot, high speed homogenization 5~8 minutes, are cooled to 55~60 DEG C of addition C phases and stir, it is cold
But to 28~35 DEG C of addition D phases, stir.
4th, after the assay was approved, discharge to obtain physical and chemical index suncream.
The application method of suncream provided by the present invention：It is outgoing the first two ten minutes, uniformly it is applied to the sun-proof position of needs.
Chemical sun is combined by the present invention with physical sunscreen agent, by liposome technology, addition is larger
Component of sun ethylhexyl methoxy cinnamate chemical sun wrapped up, reduction ethylhexyl methoxy cinnamate prevent
Stimulation of the agent to skin is shone, the harmful effect of existing physical sunscreen and chemical sunscreen is solved, sun-proof result can not only be reached, and
The security of product can be increased, excitant is reduced, the growing sun-proof demand of consumer is met, with stronger safety
Property, use feeling is remarkably reinforced, and is sun-proof good merchantable brand of a summer.
Embodiment
Below by embodiment, the invention will be further described, but not as a limitation of the invention.
The compositing formula of each embodiment is shown in Table 1, in terms of weight percentage.
The compositing formula of each embodiment of table 1
The preparation technology of above-described embodiment is as follows：
1st, B is added in emulsification pot, is heated to 80~85 DEG C, low speed homogeneous 2~5 minutes is incubated 25~40 minutes.
2nd, A is added in oil cauldron, is heated to 80~85 DEG C, be incubated 25~40 minutes.
3rd, A phases are pumped into emulsification pot, high speed homogenization 5~8 minutes, are cooled to 55~60 DEG C of addition C phases and stir, it is cold
But to 28~35 DEG C of addition D phases, stir.
4th, after the assay was approved, discharge to obtain physical and chemical index suncream.
Efficacy validation：
Random to select 120 volunteers, each people of embodiment trier 20 a, arm smears suncream, and one does not apply,
Shone half an hour under daily sunshine, two tanned degree of arm of control and evaluate suncream whether allergy, it is continuous to use 15 days,
It the results are shown in Table 2, effect point Three Estate：
Substantially：The arm for smearing suncream and the arm contrast for not smearing suncream are obvious, smear the arm skin of suncream
Skin is pale, non-stimulated, and the tanned sunburn of arm that suncream is not smeared is obvious.
It is obvious：The arm for smearing suncream contrasts obvious with the arm for not smearing suncream, smears suncream
Arm skin color it is more black, it is non-stimulated：The arm for not smearing suncream is tanned substantially.
It is unobvious：The arm for smearing suncream contrasts unobvious with the arm for not smearing suncream, smears the hand of suncream
Skin of arm color is black with as the arm for not smearing suncream, and the arm of smearing suncream has allergic reaction.
Each embodiment using effect of table 2
| Case study on implementation | Substantially | It is obvious | It is unobvious | Excitant |
| Embodiment 1 | 18 | 2 | 0 | 0 |
| Embodiment 2 | 18 | 2 | 0 | 0 |
| Embodiment 3 | 18 | 2 | 0 | 0 |
| Embodiment 4 | 19 | 1 | 0 | 0 |
| Embodiment 5 | 20 | 0 | 0 | 0 |
| Embodiment 6 | 20 | 0 | 0 | 0 |
Prevent that skin tanning sunburn is efficient using suncream provided by the present invention it can be seen from above-mentioned using effect
Up to 100%.Without 1 generation allergy.Both effectively prevent skin because ultraviolet irradiate caused by tanned sunburn, be avoided that again because
Add allergic caused by substantial amounts of ethylhexyl methoxy cinnamate chemical sun, improve the safety of sunscreen product
Property.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, some improvements and modifications can also be made, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Claims (2)
1. a kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing, it is characterised in that containing following heavy
Measure percent composition：
A phases
Cocoyl glucoside 1.5~4.0%
Cetostearyl alcohol 2~4.0%
Phosphoric acid monohexadecyl ester potassium 0.5~1.0%
Carbonic acid dioctyl ester 5~8%
Ethylhexyl methoxy cinnamate liposome thing 5~8%
Titanium dioxide 2~4%
Silica 0.06~0.12%
Triethoxy octyl group silane 0.2~0.4%
Uvinul A Plus 1~3%
Octocrilene 2~4%
Diethylhexyl Butamido Triazon 0.8~2%
Tocopherol acetate 0.5~2%
Caprylic/capric triglyceride 2~4%
Cetyl dimethicone 1~3%
B phases
Butanediol 5~10%
Pearl hydrolysate liposome 5~10%
Arabic gum natural gum 0.2~0.4%
Xanthans 0.2~0.4%
Magnesiumaluminumsilicate 0.2~0.4%
Glycine betaine 2~4%
Phenylbenzimidazolesulfonic acid 2.0~4%
Arginine 1.2~2%
EDTA-2Na 0.05~0.15%
Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers 0.8~2%
Saualane 0.2~0.4%
Polysorbate -60 0.03~0.05%
The smooth isostearate 0.015~0.03% of sorb
Pure water to 100%
C phases
MBBT 2~4%
Plantacare 818 0.8~2%
Xylitol-based glucoside 0.2~0.8%
Anhydro xylitol 0.1~0.5%
Xylitol 0.15~0.3%
Glucose 0.05~0.1%
Bisabolol 0.16~0.3%
Fanesol 0.04~0.08%
Panthenol 0.4~1.5%
PEG/PPG-17/6 copolymer 1 .5~2.5%
D phases
Essence 0.05~0.2%.
2. the preparation method of the suncream described in a kind of claim 1, it is characterised in that wrapped up sun-screening agent, its step is such as
Under：
1), B is added in emulsification pot, 80~85 DEG C are heated to, low speed homogeneous 2~5 minutes is incubated 25~40 minutes；
2), A is added in oil cauldron, 80~85 DEG C are heated to, 25~40 minutes are incubated；
3), A phases are pumped into emulsification pot, high speed homogenization 5~8 minutes, are cooled to 55~60 DEG C of addition C phases and stir, cool down
To 28~35 DEG C of addition D phases, stir；
4), after the assay was approved, discharge to obtain physical and chemical index suncream.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710314056.8A CN107157788A (en) | 2017-05-05 | 2017-05-05 | A kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing |
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| CN201710314056.8A CN107157788A (en) | 2017-05-05 | 2017-05-05 | A kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing |
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Family
ID=59813178
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|---|---|---|---|
| CN201710314056.8A Withdrawn CN107157788A (en) | 2017-05-05 | 2017-05-05 | A kind of suncream for adding ethylhexyl methoxy cinnamate liposome thing |
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| CN110585069A (en) * | 2019-10-12 | 2019-12-20 | 广州市百好博有限公司 | Oil-control lasting liquid foundation and preparation method thereof |
| WO2020158402A1 (en) * | 2019-01-29 | 2020-08-06 | 株式会社 資生堂 | External preparation for skin and method for improving ultraviolet protection effect |
| CN111658599A (en) * | 2020-07-17 | 2020-09-15 | 广东芭薇生物科技股份有限公司 | Liposome sunscreen cosmetic and preparation method thereof |
| CN112370406A (en) * | 2020-11-30 | 2021-02-19 | 广东丸美生物技术股份有限公司 | Low-irritation sunscreen lotion and preparation method thereof |
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| CN118384055A (en) * | 2024-04-10 | 2024-07-26 | 广州市仙迪生物科技有限公司 | A high-permeability recombinant collagen liposome and its preparation method and application |
| CN118384055B (en) * | 2024-04-10 | 2025-03-28 | 广州市仙迪生物科技有限公司 | A high-permeability recombinant collagen liposome and its preparation method and application |
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Application publication date: 20170915 |