CN107096008A - One kind releive pain relieving ointment and preparation method thereof, application - Google Patents
One kind releive pain relieving ointment and preparation method thereof, application Download PDFInfo
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- CN107096008A CN107096008A CN201710244151.5A CN201710244151A CN107096008A CN 107096008 A CN107096008 A CN 107096008A CN 201710244151 A CN201710244151 A CN 201710244151A CN 107096008 A CN107096008 A CN 107096008A
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- parts
- oil
- siphon
- eucommia
- extract solution
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- 208000002193 Pain Diseases 0.000 title claims abstract description 42
- 230000036407 pain Effects 0.000 title claims abstract description 42
- 239000002674 ointment Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims description 19
- 239000000284 extract Substances 0.000 claims abstract description 108
- 239000003921 oil Substances 0.000 claims abstract description 52
- 235000019198 oils Nutrition 0.000 claims abstract description 52
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
- 244000237330 gutta percha tree Species 0.000 claims abstract description 36
- 239000003814 drug Substances 0.000 claims abstract description 33
- 241000208688 Eucommia Species 0.000 claims abstract description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 26
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000003381 stabilizer Substances 0.000 claims abstract description 17
- 244000166675 Cymbopogon nardus Species 0.000 claims abstract description 13
- 235000018791 Cymbopogon nardus Nutrition 0.000 claims abstract description 13
- 235000004692 Eucalyptus globulus Nutrition 0.000 claims abstract description 13
- 240000007002 Eucalyptus tereticornis Species 0.000 claims abstract description 13
- 235000019134 Eucalyptus tereticornis Nutrition 0.000 claims abstract description 13
- 235000011187 glycerol Nutrition 0.000 claims abstract description 13
- 229960001047 methyl salicylate Drugs 0.000 claims abstract description 13
- 239000010671 sandalwood oil Substances 0.000 claims abstract description 13
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 12
- 229920000615 alginic acid Polymers 0.000 claims abstract description 12
- 239000002562 thickening agent Substances 0.000 claims abstract description 12
- 239000001771 mentha piperita Substances 0.000 claims abstract description 10
- 235000019719 rose oil Nutrition 0.000 claims abstract description 10
- 239000010666 rose oil Substances 0.000 claims abstract description 10
- 208000014674 injury Diseases 0.000 claims abstract description 7
- 230000008736 traumatic injury Effects 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 56
- 241000345998 Calamus manan Species 0.000 claims description 25
- 235000012950 rattan cane Nutrition 0.000 claims description 25
- 239000002904 solvent Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 12
- 235000010676 Ocimum basilicum Nutrition 0.000 claims description 12
- 240000007926 Ocimum gratissimum Species 0.000 claims description 12
- 244000269722 Thea sinensis Species 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- 238000000967 suction filtration Methods 0.000 claims description 10
- 238000005292 vacuum distillation Methods 0.000 claims description 10
- 238000009423 ventilation Methods 0.000 claims description 7
- 239000004115 Sodium Silicate Substances 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 6
- 235000019795 sodium metasilicate Nutrition 0.000 claims description 6
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 6
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 229920006395 saturated elastomer Polymers 0.000 claims description 5
- 239000001632 sodium acetate Substances 0.000 claims description 5
- 235000017281 sodium acetate Nutrition 0.000 claims description 5
- 235000002639 sodium chloride Nutrition 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 235000013616 tea Nutrition 0.000 claims description 5
- 238000010792 warming Methods 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 4
- 241000220317 Rosa Species 0.000 claims description 3
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 235000008397 ginger Nutrition 0.000 claims description 3
- 244000273928 Zingiber officinale Species 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 235000013372 meat Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 38
- 208000014617 hemorrhoid Diseases 0.000 abstract description 7
- 206010003246 arthritis Diseases 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 11
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 102000003929 Transaminases Human genes 0.000 description 4
- 108090000340 Transaminases Proteins 0.000 description 4
- 239000000730 antalgic agent Substances 0.000 description 4
- 238000002651 drug therapy Methods 0.000 description 4
- 229940002508 ginger extract Drugs 0.000 description 4
- 235000020708 ginger extract Nutrition 0.000 description 4
- 230000003908 liver function Effects 0.000 description 4
- 230000008058 pain sensation Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 240000002853 Nelumbo nucifera Species 0.000 description 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 238000007449 liver function test Methods 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000019804 backache Diseases 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61K36/534—Mentha (mint)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention discloses one kind and releived pain relieving ointment, including following component：10~30 parts of glycerine, 2~8 parts of algin, 0.5~1 part of methyl salicylate, 10~20 parts of peppermint leaf oil, 5~7 parts of citronella grass oil, 4~8 parts of blue gum leaf oil, 5~20 parts of eucommia ulmoides extracts, 5~10 parts of rose oil, 3~10 parts of sandalwood oil, very heavy group of 4~10 parts of extract solution, 3~10 parts of You Jiali extract solutions, 2~8 parts of siphon extract solution, 0.5~1.5 part of Ginger P.E, 1~20 part of water, 2~5 parts of system stabilizers, 0.05~3 part of thickener, 0.1~5 part of ethanol.Formula employed in the present invention has clearing away heat to and alleviating pain, effect promoting blood circulation and removing blood stasis, from the eucommia Bark male flower Jing Guo specially treated, strengthen effect complementation of itself and other components in medicine, there is instant effect, good effect and effect uneasy to recur for obstinate grieved particularly arthritis ache, traumatic injury and the hemorrhoid for the treatment of.
Description
Technical field
The invention belongs to medical medicine technical field, and in particular to one kind is releived pain relieving ointment and preparation method thereof, purposes.
Background technology
Rhythm with life, work is constantly accelerated, and all kinds of pain class diseases are also emerged in large numbers one after another, work of particularly bending over the desk for a long time
Make or arduous work person, the sick and wounded problem such as back ache, pulled muscle, arthralgia annoyings patient, to patient just
Often life brings very big inconvenience.Currently for this illness frequently with physical treatment method, such as hot compress, toast, press
Rub, but these treatment methods take effect relatively slowly, and also method is not easy to produce secondary injury to affected part to if；In addition it is directed to
These pain patients select to use anodyne link, and anodyne is a kind of nerve anesthesia medicine, and long-term taking can be made to patient
Into larger side effect.Accordingly, it would be desirable to develop a kind of instant effect and toxic side effect is small, be difficult analgesic drug product of releiving repeatedly.
The content of the invention
Goal of the invention：Present invention aims at there is provided a kind of seeing suitable for various people in view of the shortcomings of the prior art
Effect is fast, toxic side effect is small and is difficult pain relieving ointment and preparation method thereof of releiving of recurrent exerbation, purposes.
Technical scheme：One kind of the present invention is releived pain relieving ointment, including following component：10~30 parts of glycerine, algin 2~
8 parts, 0.5~1 part of methyl salicylate, 10~20 parts of peppermint leaf oil, 5~7 parts of citronella grass oil, 4~8 parts of blue gum leaf oil, eucommia ulmoides extracts 5
~20 parts, 5~10 parts of rose oil, 3~10 parts of sandalwood oil, very heavy group of 4~10 parts of extract solution, 3~10 parts of You Jiali extract solutions,
2~8 parts of siphon extract solution, 0.5~1.5 part of Ginger P.E, 2~5 parts of tea leaf oil, 1~5 part of basil, 1~20 part of water,
2~5 parts of system stabilizers, 0.05~3 part of thickener, 0.1~5 part of ethanol, in terms of weight fraction；
The eucommia ulmoides extracts extract from eucommia Bark male flower, and its specific preparation method is as follows：
(11) take at ripe eucommia Bark male flower, 35~40 DEG C immerse mass fraction for 25wt% sodium acetate aqueous solution in 24~
36h, then takes out, and ventilation bakees drying at 45~50 DEG C, obtains bark of eucommia dried flower；
(12) obtained bark of eucommia dried flower in step (1) is smashed to pieces, and eucommia flower powder is immersed into acetic acid at 35~45 DEG C
12~24h in ethyl ester solvent, then repeatedly vacuum distillation recovered solvent after suction filtration 2~4 times, obtains one-level eucommia ulmoides extracts；
(13) 12~24h in ethanol will be immersed in one-level extract in step (2) at normal temperatures sealed environment, then repeated
Vacuum distillation recovered solvent after suction filtration 2~4 times, obtains two grades of eucommia ulmoides extracts；Two grades of eucommia ulmoides extracts deionized water rinsings
Obtain the eucommia ulmoides extracts of the present invention；
The specific preparation method of the siphon extract solution is as follows：
(21) take siphon rattan peel to be soaked in 24~36h in saturated aqueous common salt at 35~45 DEG C, then take out, 40~
Ventilation bakees drying at 55 DEG C, obtains dry siphon rattan peel；
(22) the drying siphon rattan peel obtained in step (1) is crushed, and its powder is immersed in deionized water, big fire
Boil rear small fire and decoct 3~6h, be then filtrated to get siphon rattan peel one-level extract solution；
(23) by under the siphon rattan peel one-level extract solution reduced pressure 0.002MPa~0.003MPa obtained in step (2)
Rectifying is carried out, the cut of 80~85 DEG C of boiling ranges is extracted, obtains siphon extract solution；
The system stabilizers include following component：
Further, the thickener is marine alga sodium metasilicate or plain digested tankage.
The present invention also provides the preparation method of above-mentioned pain relieving ointment of releiving, it is characterised in that specific as follows：
(31) by peppermint leaf oil, citronella grass oil, blue gum leaf oil, rose oil, tea leaf oil, basil, methyl salicylate, very heavy group
It is uniformly mixed under extract solution and sandalwood oil room temperature condition, then adds You Jiali extract solutions, siphon extract solution and life
Ginger extract continues to stir to well mixed；
(32) above-mentioned system is warming up to 35~45 DEG C and adds algin, water and thickener, continue to add after being stirred until homogeneous
Enter eucommia ulmoides extracts and ethanol, continue to stir 2~4h and system is down to room temperature in whipping process, it is rear to add glycerine and system
Stabilizer stirs 0.5~1h and obtains pain relieving ointment of releiving.
Present invention also offers above-mentioned application of the pain relieving ointment in treatment traumatic injury, painful swelling of joints medicine of releiving.
Present invention also offers above-mentioned application of the pain relieving ointment in medicine for treaching hemorrhoie of releiving.
Further, when as medicine for treaching hemorrhoie, the pain relieving ointment of releiving includes following component：28 parts of glycerine, sea
6 parts of phycocolloid, 0.8 part of methyl salicylate, 15 parts of peppermint leaf oil, 5 parts of citronella grass oil, 4 parts of blue gum leaf oil, 18 parts of eucommia ulmoides extracts, rose
8 parts of caul-fat, 4 parts of sandalwood oil, very heavy group of 8 parts of extract solution, 8 parts of You Jiali extract solutions, 3.5 parts of siphon extract solution, ginger is extracted
1 part of thing, 2 parts of tea leaf oil, 2 parts of basil, 5 parts of water, 2.5 parts of system stabilizers, 1 part of thickener, 2 parts of ethanol, with weight fraction
Meter.
Beneficial effect：(1) formula employed in the present invention has clearing away heat to and alleviating pain, effect promoting blood circulation and removing blood stasis, from process
The eucommia Bark male flower of specially treated, and two grades of extraction processes are used to it, the extract for obtaining being adapted to this pharmaceutical formulation is extracted, is improved
Medicine is releived the effect of analgesic；80~85 DEG C are obtained under reduced pressure 0.002MPa~0.003MPa by specific extraction process
The siphon extract solution of boiling range, improves efficient constituent content in drug component, improves medicine quality；(2) lead in this drug component
Cross and add special system stabilizers, improve the stability of the medicine, increase the medicine resting period, and the stabiliser system has
Nontoxic the characteristics of, do not have a negative impact to effect of drugs and patient；(3) formula of this medicine has functional diversity
The characteristics of, other curative effect medicines special can be done when adjusting each component ratio a to particular range, such as hemorrhoid treating medicine is controlled
Therapeutic effect is notable；(4) complementation of each component effect is strengthened in this medicine, for the obstinate grieved particularly arthritis ache for the treatment of, falls
Beating damage and hemorrhoid etc. has instant effect, good effect and effect uneasy to recur.
Embodiment
Technical solution of the present invention is described in detail below by embodiment, but protection scope of the present invention is not limited to
In the embodiment.
Embodiment 1：One kind is releived pain relieving ointment, including following component：10 parts of glycerine, 2 parts of algin, 0.5 part of methyl salicylate is thin
10 parts of lotus leaf oil, 5 parts of citronella grass oil, 4 parts of blue gum leaf oil, 5 parts of eucommia ulmoides extracts, 5 parts of rose oil, 3 parts, very heavy group of sandalwood oil
4 parts of extract solution, 3 parts of You Jiali extract solutions, 2 parts of siphon extract solution, 0.5 part of Ginger P.E, 2 parts of tea leaf oil, basil 1
Part, 2.5 parts of water, 2.5 parts of system stabilizers, 0.2 part of marine alga sodium metasilicate, 0.15 part of ethanol, in terms of weight fraction；
The eucommia ulmoides extracts extract from eucommia Bark male flower, and its specific preparation method is as follows：
(11) take and 24h in the sodium acetate aqueous solution that mass fraction is 25wt% is immersed at ripe eucommia Bark male flower, 35 DEG C, then
Take out, ventilation bakees drying at 45 DEG C, obtains bark of eucommia dried flower；
(12) obtained bark of eucommia dried flower in step (1) is smashed to pieces, and eucommia flower powder is immersed into ethyl acetate at 35 DEG C
12h in solvent, then repeatedly vacuum distillation recovered solvent after suction filtration 2 times, obtains one-level eucommia ulmoides extracts；
(13) 12h in ethanol will be immersed in one-level extract in step (2) at normal temperatures sealed environment, then repeatedly suction filtration
Vacuum distillation recovered solvent after 2 times, obtains two grades of eucommia ulmoides extracts；Two grades of eucommia ulmoides extracts obtain this hair with deionized water rinsing
Bright eucommia ulmoides extracts；
The specific preparation method of the siphon extract solution is as follows：
(21) take siphon rattan peel to be soaked in 24h in saturated aqueous common salt at 35 DEG C, then take out, divulge information and dry at 40 DEG C
Dry dry, obtain dry siphon rattan peel；
(22) the drying siphon rattan peel obtained in step (1) is crushed, and its powder is immersed in deionized water, big fire
Boil rear small fire and decoct 3h, be then filtrated to get siphon rattan peel one-level extract solution；
(23) rectifying will be carried out under the siphon rattan peel one-level extract solution reduced pressure 0.002MPa obtained in step (2),
The cut of 80~82 DEG C of boiling ranges is extracted, siphon extract solution is obtained；
The system stabilizers include following component：
Further, the thickener is or plain digested tankage.
The present invention also provides the preparation method of above-mentioned pain relieving ointment of releiving, it is characterised in that specific as follows：
(31) by peppermint leaf oil, citronella grass oil, blue gum leaf oil, rose oil, tea leaf oil, basil, methyl salicylate, very heavy group
It is uniformly mixed under extract solution and sandalwood oil room temperature condition, then adds You Jiali extract solutions, siphon extract solution and life
Ginger extract continues to stir to well mixed；
(32) above-mentioned system is warming up to 35 DEG C and adds algin, water and marine alga sodium metasilicate, continue to add after being stirred until homogeneous
Enter eucommia ulmoides extracts and ethanol, continue to stir 2h and system is down to room temperature in whipping process, rear addition glycerine and system are steady
Determine agent stirring 0.5h and obtain pain relieving ointment of releiving.
The cream provided in the present invention can be used for the treatment of painful swelling of joints, be the curative effect for further verifying this prescription to patient,
Treatment track record is carried out to 100 cases, patient is divided into gently by patient's average age 44~66 years old, average course of disease 4.5 years
Degree, moderate and severe, the normal walking of patients with mild is particularly overcast and rainy mild pain sensation；Moderate patient normally walks spy
It is not overcast and rainy to have obvious sensation of pain；Severe patient can not normally walk substantially.Treated using this prescription, specific side
Method is erasing, three times per day, half an hour is massaged after erasing, and for different degrees of patient, therapeutic effect is as shown in table 1, effective
Refer to after medication effect in 5 days significantly, the case that eliminates of pain；Effectively refer to that effect is notable, pain elimination in 20 days
In case, invalid finger 30 days substantially to no effect, the indelible case of pain；Recovery from illness refers in 5 days effect significantly and 180 days
The case not recurred inside.
Table 1 is using efficacy data of the medicine of the present invention to different painful swelling of joints degree patients
| Degree | Recovery from illness | It is effective | Effectively | It is invalid | It is total | It is efficient |
| Slightly | 18 | 30 | 8 | 2 | 58 | 96.6% |
| Moderate | 7 | 12 | 4 | 3 | 26 | 88.5% |
| Severe | 4 | 4 | 5 | 3 | 16 | 81.2% |
Further to verify the security of this prescription, kept track of while carrying out drug therapy control to another crowd of patient,
100 patients of same selection, patient's average age 44~66 years old, average course of disease 4.5 years, treatment group is controlled using this drug administration
Treat, control group uses general analgesic drug product drug treatment, is periodically administered and periodically carries out liver function test, through randomized controlled treatment knot
Fruit proves that the phenomenon normally, without transaminase jumped using treatment group's Liver function grade of this medicine, patient's states are steady；Using
Compare the patient of administration, occur the elevated phenomenon of transaminase in Liver function grade, and also have simultaneously some patientss with dizziness,
The phenomenon of vomiting, is thus proved, the security that this medicine is used.
Embodiment 2：One kind is releived pain relieving ointment, including following component：28 parts of glycerine, 8 parts of algin, 1 part of methyl salicylate, peppermint
20 parts of leaf oil, 7 parts of citronella grass oil, 8 parts of blue gum leaf oil, 20 parts of eucommia ulmoides extracts, 10 parts of rose oil, 10 parts of sandalwood oil is very heavy
Dial 10 parts of extract solution, 10 parts of You Jiali extract solutions, 8 parts of siphon extract solution, 1.5 parts of Ginger P.E, 5 parts of tea leaf oil, sweet basil
5 parts of oil, 18 parts of water, 5 parts of system stabilizers, plain 3.7 parts of digested tankage, 4.2 parts of ethanol, in terms of weight fraction；
The eucommia ulmoides extracts extract from eucommia Bark male flower, and its specific preparation method is as follows：
(11) take and 36h in the sodium acetate aqueous solution that mass fraction is 25wt% is immersed at ripe eucommia Bark male flower, 40 DEG C, then
Take out, ventilation bakees drying at 50 DEG C, obtains bark of eucommia dried flower；
(12) obtained bark of eucommia dried flower in step (1) is smashed to pieces, and eucommia flower powder is immersed into ethyl acetate at 45 DEG C
24h in solvent, then repeatedly vacuum distillation recovered solvent after suction filtration 4 times, obtains one-level eucommia ulmoides extracts；
(13) 24h in ethanol will be immersed in one-level extract in step (2) at normal temperatures sealed environment, then repeatedly suction filtration
Vacuum distillation recovered solvent after 4 times, obtains two grades of eucommia ulmoides extracts；Two grades of eucommia ulmoides extracts obtain this hair with deionized water rinsing
Bright eucommia ulmoides extracts；
The specific preparation method of the siphon extract solution is as follows：
(21) take siphon rattan peel to be soaked in 36h in saturated aqueous common salt at 45 DEG C, then take out, divulge information and dry at 55 DEG C
Dry dry, obtain dry siphon rattan peel；
(22) the drying siphon rattan peel obtained in step (1) is crushed, and its powder is immersed in deionized water, big fire
Boil rear small fire and decoct 6h, be then filtrated to get siphon rattan peel one-level extract solution；
(23) rectifying will be carried out under the siphon rattan peel one-level extract solution reduced pressure 0.003MPa obtained in step (2),
The cut of 83~85 DEG C of boiling ranges is extracted, siphon extract solution is obtained；
The system stabilizers include following component：
Further, the thickener is marine alga sodium metasilicate or plain digested tankage.
The present invention also provides the preparation method of above-mentioned pain relieving ointment of releiving, it is characterised in that specific as follows：
(31) by peppermint leaf oil, citronella grass oil, blue gum leaf oil, rose oil, tea leaf oil, basil, methyl salicylate, very heavy group
It is uniformly mixed under extract solution and sandalwood oil room temperature condition, then adds You Jiali extract solutions, siphon extract solution and life
Ginger extract continues to stir to well mixed；
(32) above-mentioned system is warming up to 35~45 DEG C and adds algin, water and plain digested tankage, continue to add after being stirred until homogeneous
Enter eucommia ulmoides extracts and ethanol, continue to stir 2~4h and system is down to room temperature in whipping process, it is rear to add glycerine and system
Stabilizer stirs 0.5~1h and obtains pain relieving ointment of releiving.
Medicine is applied to the treatment for the treatment of traumatic injury in the present embodiment, is the treatment for further verifying this prescription to patient
100 cases are carried out treatment track record by effect, and patient is divided into by patient's average age 15~70 years old, average course of disease 2.5 months
Slightly, moderate and severe, patients with mild pressing affected part have hypodynia sensation；Moderate patient, which does not press, has obvious pain
Feel；Severe patient pain sense is larger, influences normal life；Treated using this prescription, specific method is erasing, one day three
It is secondary, half an hour is massaged after erasing, for different degrees of patient, therapeutic effect is as shown in table 2, effective to refer to after medication in 5 days
The case that effect is notable, pain is eliminated；Effectively refer to effect in 20 days significantly, the case that eliminates of pain, invalid finger 30 days
Inside substantially to no effect, the indelible case of pain；Recovery from illness refers to the case that effect does not recur significantly and in 180 days in 5 days.
Table 2 is using efficacy data of the medicine of the present invention to different degrees of traumatic injury patient
| Degree | Recovery from illness | It is effective | Effectively | It is invalid | It is total | It is efficient |
| Slightly | 18 | 24 | 15 | 3 | 60 | 95.0% |
| Moderate | 3 | 15 | 3 | 2 | 23 | 91.3% |
| Severe | 2 | 10 | 5 | 3 | 17 | 82.3% |
Proved by upper table, using this drug therapy traumatic injury, preferable curative effect be respectively provided with for different degrees of patient,
And toxic side effect is substantially zero, used suitable for various crowds treatment.
Embodiment 3：One kind is releived pain relieving ointment, including following component：28 parts of glycerine, 6 parts of algin, 0.8 part of methyl salicylate is thin
15 parts of lotus leaf oil, 5 parts of citronella grass oil, 4 parts of blue gum leaf oil, 18 parts of eucommia ulmoides extracts, 8 parts of rose oil, 4 parts of sandalwood oil is very heavy
Dial 8 parts of extract solution, 8 parts of You Jiali extract solutions, 3.5 parts of siphon extract solution, 1 part of Ginger P.E, 2 parts of tea leaf oil, basil 2
Part, 5 parts of water, 3.95 parts of system stabilizers, 1 part of marine alga sodium metasilicate, 2 parts of ethanol, in terms of weight fraction；
The eucommia ulmoides extracts extract from eucommia Bark male flower, and its specific preparation method is as follows：
(11) take and 30h in the sodium acetate aqueous solution that mass fraction is 25wt% is immersed at ripe eucommia Bark male flower, 38 DEG C, then
Take out, ventilation bakees drying at 48 DEG C, obtains bark of eucommia dried flower；
(12) obtained bark of eucommia dried flower in step (1) is smashed to pieces, and eucommia flower powder is immersed into ethyl acetate at 40 DEG C
20h in solvent, then repeatedly vacuum distillation recovered solvent after suction filtration 3 times, obtains one-level eucommia ulmoides extracts；
(13) 20h in ethanol will be immersed in one-level extract in step (2) at normal temperatures sealed environment, then repeatedly suction filtration
Vacuum distillation recovered solvent after 3 times, obtains two grades of eucommia ulmoides extracts；Two grades of eucommia ulmoides extracts obtain this hair with deionized water rinsing
Bright eucommia ulmoides extracts；
The specific preparation method of the siphon extract solution is as follows：
(21) take siphon rattan peel to be soaked in 30h in saturated aqueous common salt at 40 DEG C, then take out, divulge information and dry at 50 DEG C
Dry dry, obtain dry siphon rattan peel；
(22) the drying siphon rattan peel obtained in step (1) is crushed, and its powder is immersed in deionized water, big fire
Boil rear small fire and decoct 4h, be then filtrated to get siphon rattan peel one-level extract solution；
(23) rectifying will be carried out under the siphon rattan peel one-level extract solution reduced pressure 0.0025MPa obtained in step (2),
The cut of 82~84 DEG C of boiling ranges is extracted, siphon extract solution is obtained；
The system stabilizers include following component：
The preparation method of above-mentioned pain relieving ointment of releiving, it is specific as follows：
(31) by peppermint leaf oil, citronella grass oil, blue gum leaf oil, rose oil, tea leaf oil, basil, methyl salicylate, very heavy group
It is uniformly mixed under extract solution and sandalwood oil room temperature condition, then adds You Jiali extract solutions, siphon extract solution and life
Ginger extract continues to stir to well mixed；
(32) above-mentioned system is warming up to 40 DEG C and adds algin, water and thickener, continue to add Du after being stirred until homogeneous
Secondary extract and ethanol, continue to stir 3h and system are down to room temperature in whipping process, rear to add glycerine and system stabilizers
Stirring 1h obtains pain relieving ointment of releiving.
The condensation provided in the present invention can be used for treatment hemorrhoid, be the curative effect for further verifying this prescription to patient, to 100
Name case carry out treatment track record, patient's average age 25~50 years old, average course of disease 2.5 years, by patient be divided into slightly, moderate
And severe, normally walking has mild pain sensation to patients with mild；Normally walking has obvious sensation of pain to moderate patient；Severe is suffered from
Person can not normally walk substantially.Treated using this prescription, specific method is erasing, three times per day, half is massaged after erasing small
When, for different degrees of patient, therapeutic effect as shown in table 3, it is effective refer to after medication in 5 days effect significantly, pain disappears
The case removed；Effectively refer to effect in 20 days significantly, the case that eliminates of pain, in invalid finger 30 days substantially to no effect, pain
Feel indelible case；Recovery from illness refers to the case that effect does not recur significantly and in 180 days in 5 days.
Table 3 is using efficacy data of the medicine of the present invention to different degrees of hemorrhoid patients
| Degree | Recovery from illness | It is effective | Effectively | It is invalid | It is total | It is efficient |
| Slightly | 15 | 26 | 9 | 6 | 56 | 89.3% |
| Moderate | 6 | 9 | 5 | 4 | 24 | 83.3% |
| Severe | 4 | 6 | 6 | 4 | 20 | 80.0% |
Further to verify the security of this prescription, kept track of while carrying out drug therapy control to another crowd of patient,
100 patients of same selection, patient's average age 25~50 years old, average course of disease 2.5 years, treatment group is controlled using this drug administration
Treat, control group uses general hemorrhoid treating class Western medicine drug treatment, be periodically administered and periodically carry out liver function test, through control
Treatment results prove that the phenomenon normally, without transaminase jumped using treatment group's Liver function grade of this medicine, patient's states are put down
Surely；Using the patient of control administration, occur the elevated phenomenon of transaminase in Liver function grade, and also have some patientss companion simultaneously
There are dizziness, the phenomenon of vomiting, thus prove, the security that this medicine is used.
Proved by upper table, using this drug therapy hemorrhoid, preferable curative effect, and poison are respectively provided with for different degrees of patient
Side effect is substantially zero, and is used suitable for various crowds treatment.
As described above, although the present invention has been represented and described with reference to specific preferred embodiment, it must not be explained
For to the limitation of itself of the invention., can be right under the premise of the spirit and scope of the present invention that appended claims are defined are not departed from
Various changes can be made in the form and details for it.
Claims (6)
- The pain relieving ointment 1. one kind is releived, it is characterised in that including following component：10~30 parts of glycerine, 2~8 parts of algin, methyl salicylate 0.5~1 part, 10~20 parts of peppermint leaf oil, 5~7 parts of citronella grass oil, 4~8 parts of blue gum leaf oil, 5~20 parts of eucommia ulmoides extracts, rose Rare 5~10 parts of caul-fat, 3~10 parts of sandalwood oil, very heavy group of 4~10 parts of extract solution, 3~10 parts of You Jiali extract solutions, siphon is carried Take 2~8 parts of liquid, 0.5~1.5 part of Ginger P.E, 2~5 parts of tea leaf oil, 1~5 part of basil, 1~20 part of water, stable system 2~5 parts of agent, 0.05~3 part of thickener, 0.1~5 part of ethanol, in terms of weight fraction；The eucommia ulmoides extracts extract from eucommia Bark male flower, and its specific preparation method is as follows：(11) take and 24~36h in the sodium acetate aqueous solution that mass fraction is 25wt% immersed at ripe eucommia Bark male flower, 35~40 DEG C, Then take out, ventilation bakees drying at 45~50 DEG C, obtains bark of eucommia dried flower；(12) obtained bark of eucommia dried flower in step (1) is smashed to pieces, and eucommia flower powder is immersed into ethyl acetate at 35~45 DEG C 12~24h in solvent, then repeatedly vacuum distillation recovered solvent after suction filtration 2~4 times, obtains one-level eucommia ulmoides extracts；(13) 12~24h in ethanol will be immersed in one-level extract in step (2) at normal temperatures sealed environment, then repeatedly suction filtration Vacuum distillation recovered solvent after 2~4 times, obtains two grades of eucommia ulmoides extracts；Two grades of eucommia ulmoides extracts are obtained with deionized water rinsing The eucommia ulmoides extracts of the present invention；The specific preparation method of the siphon extract solution is as follows：(21) take siphon rattan peel to be soaked in 24~36h in saturated aqueous common salt at 35~45 DEG C, then take out, at 40~55 DEG C Lower ventilation bakees drying, obtains dry siphon rattan peel；(22) the drying siphon rattan peel obtained in step (1) is crushed, and its powder is immersed in deionized water, be boiled by fire Small fire decocts 3~6h afterwards, is then filtrated to get siphon rattan peel one-level extract solution；(23) it will be carried out under the siphon rattan peel one-level extract solution reduced pressure 0.002MPa~0.003MPa obtained in step (2) Rectifying, extracts the cut of 80~85 DEG C of boiling ranges, obtains siphon extract solution；The system stabilizers include following component：In terms of weight fraction.
- 2. pain relieving ointment according to claim 1 of releiving, it is characterised in that：The thickener is marine alga sodium metasilicate or plain meat Powder.
- 3. the preparation method for pain relieving ointment of being releived described in a kind of claim 1, it is characterised in that specific as follows：(31) by peppermint leaf oil, citronella grass oil, blue gum leaf oil, rose oil, tea leaf oil, basil, methyl salicylate, very heavy group of extraction It is uniformly mixed under liquid and sandalwood oil room temperature condition, then adds You Jiali extract solutions, siphon extract solution and ginger and carry Thing is taken to continue to stir to well mixed；(32) above-mentioned system is warming up to 35~45 DEG C and adds algin, water and thickener, continue to add Du after being stirred until homogeneous Secondary extract and ethanol, continue to stir 2~4h and system are down to room temperature in whipping process, rear to add glycerine and stable system Agent stirs 0.5~1h and obtains pain relieving ointment of releiving.
- 4. application of the pain relieving ointment in treatment traumatic injury, painful swelling of joints medicine of being releived described in claim 1.
- 5. application of the pain relieving ointment in medicine for treaching hemorrhoie of being releived described in claim 1.
- 6. application according to claim 5, it is characterised in that the pain relieving ointment of releiving includes following component：28 parts of glycerine, 6 parts of algin, 0.8 part of methyl salicylate, 15 parts of peppermint leaf oil, 5 parts of citronella grass oil, 4 parts of blue gum leaf oil, 18 parts of eucommia ulmoides extracts, rose Rare 8 parts of caul-fat, 4 parts of sandalwood oil, very heavy group of 8 parts of extract solution, 8 parts of You Jiali extract solutions, 3.5 parts of siphon extract solution, ginger is carried Take 1 part of thing, 2 parts of tea leaf oil, 2 parts of basil, 5 parts of water, 2.5 parts of system stabilizers, 1 part of thickener, 2 parts of ethanol, with weight point Number meter.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107926249A (en) * | 2017-11-27 | 2018-04-20 | 桂林斯泰硕农农业科技有限公司 | Fertilizing method for enhancing anticancer effect of Bufna rhizome |
| CN108485488A (en) * | 2018-04-08 | 2018-09-04 | 上海睿沁环保科技有限公司 | A kind of degradable formaldehyde high-efficiency scavenging agent |
| CN108485491A (en) * | 2018-04-08 | 2018-09-04 | 上海睿沁环保科技有限公司 | A kind of solid wood furniture surface peculiar smell removes care agent |
| CN108524779A (en) * | 2018-06-25 | 2018-09-14 | 安徽德睿轩科技服务有限公司 | A kind of ointment that treating anorectal disease and application |
| CN108607357A (en) * | 2018-04-08 | 2018-10-02 | 上海睿沁环保科技有限公司 | A kind of efficiently automobile-used odor scavenging agent |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215157A (en) * | 2016-08-29 | 2016-12-14 | 张东旭 | A kind of auxiliary moxibustion Chinese medicine oil and preparation method thereof |
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2017
- 2017-04-14 CN CN201710244151.5A patent/CN107096008A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215157A (en) * | 2016-08-29 | 2016-12-14 | 张东旭 | A kind of auxiliary moxibustion Chinese medicine oil and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107926249A (en) * | 2017-11-27 | 2018-04-20 | 桂林斯泰硕农农业科技有限公司 | Fertilizing method for enhancing anticancer effect of Bufna rhizome |
| CN108485488A (en) * | 2018-04-08 | 2018-09-04 | 上海睿沁环保科技有限公司 | A kind of degradable formaldehyde high-efficiency scavenging agent |
| CN108485491A (en) * | 2018-04-08 | 2018-09-04 | 上海睿沁环保科技有限公司 | A kind of solid wood furniture surface peculiar smell removes care agent |
| CN108607357A (en) * | 2018-04-08 | 2018-10-02 | 上海睿沁环保科技有限公司 | A kind of efficiently automobile-used odor scavenging agent |
| CN108524779A (en) * | 2018-06-25 | 2018-09-14 | 安徽德睿轩科技服务有限公司 | A kind of ointment that treating anorectal disease and application |
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Application publication date: 20170829 |