CN106975044A - It is a kind of to treat medicine of calculus and its preparation method and application - Google Patents
It is a kind of to treat medicine of calculus and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of medicine for treating calculus and its preparation method and application, the medicine is made up of the raw material below according to parts by weight：30 40 parts of Kaempferia galanga, 7 15 parts of waras, 21 29 parts of Radix Stellariae Yunnanensis, 13 21 parts of aleppo avens herb.Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crushed, 75% alcohol reflux is added and extracts 3 times, merges extract solution, concentrates, is dried to obtain mixture A；By Kaempferia galanga and waras ultramicro grinding；Add white wine dipping, filter to take filtrate, the obtained mixture B of vacuum alcohol extracting；Mixture A is mixed evenly with mixture B, stirs to dry and produces at a temperature of 88 90 DEG C.The present invention calculus is worked after with comminuted discharge, strengthen immune function of human body and resistance against diseases, there is fabulous curative effect for calculus, total effective rate is up to more than 98%.Medicine of the present invention has no side effect safely to kidney stone non-relapse after healing, can reach wide popularization and application on the purpose treated both principal and secondary aspect of disease, clinic.
Description
Technical field
It is specifically a kind of to treat medicine of calculus and its preparation method and application the present invention relates to pharmaceutical technology field.
Background technology
In catheter lumen in human body or animal body or luminal organ（Such as kidney, ureter, gall-bladder or bladder）Chamber in
The solid mass of formation.It is mainly seen in gall-bladder and bladder, renal plevis, also seen in the chamber of pancreas conduit, salivary ducts etc..Knot
Stone is made up of inorganic salts or organic matter.Typically there is a core in calculus, by the epithelial cell, bacterial aggregate, parasitic ovum come off
Or polypide, excrement block or foreign matter composition, inorganic salts or organic matter are deposited on core layer by layer again.Due to the difference of afflicted organ, knot
Composition, shape, quality contained by the mechanism of stone formation, influence to body etc. are differed.Generally speaking, calculus can cause pipe
Chamber blocks, and influences the discharge of afflicted organ's liquid, produces the symptoms such as pain, bleeding or secondary infection.
Wherein kidney stone is to cause the precipitation of urine crystalline solid in kidney to form by many reasons.Common kidney stone shape
The origin cause of formation have urethremphraxis, infection, dystrophia, endocrine system disease, long-term bed, but also has many patients to have no determination
Reason can be sought.Kidney stone is mainly shown as the symptoms such as flank pain, blood urine, pyuria, and many patients are because waist is acutely twisted
What pain was found after seeing a doctor.A kind of most commonly seen illness its cause of disease of urinary system is complicated and imperfectly understands, may with heredity,
Itself lesion of metabolism, environment, whole body or uropoiesis is relevant, is a kind of calculus of recurrent exerbation.
Traditional treatment calculus mode is cured the symptoms, not the disease, and doctor trained in Western medicine medication side effect is big, does not reach the mesh cured completely
, recurrent exerbation, the time is long.
The content of the invention
It is an object of the invention to provide a kind of medicine for treating calculus and its preparation method and application, to solve the above-mentioned back of the body
The problem of being proposed in scape technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of medicine for treating calculus, is made up of the raw material below according to parts by weight：30-40 parts of Kaempferia galanga, 7-15 parts of waras, thousand
21-29 parts of the line of pin ten thousand grass, 13-21 parts of aleppo avens herb.
It is used as further scheme of the invention：The medicine of the treatment calculus, is made up of the raw material below according to parts by weight：
32-38 parts of Kaempferia galanga, 9-13 parts of waras, 23-27 parts of Radix Stellariae Yunnanensis, 15-19 parts of aleppo avens herb.
It is used as further scheme of the invention：The medicine of the treatment calculus, is made up of the raw material below according to parts by weight：
35 parts of Kaempferia galanga, 11 parts of waras, 25 parts of Radix Stellariae Yunnanensis, 17 parts of aleppo avens herb.
Another object of the present invention is to provide a kind of preparation method of the medicine of the treatment calculus, comprises the following steps：
1）Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crush, cross 60-100 mesh sieves, the volume fraction of the two 9 times of quality is added
75% alcohol reflux is extracted 3 times, each 3.3h, merges extract solution, is concentrated, and is dried, is obtained mixture A；
2）Kaempferia galanga and waras are subjected to ultramicro grinding to 400-500 mesh；Add 7-8 times of weight 40-50 degree white wine, 55-58 DEG C
Lower stirring dipping 30-33h；Filter to take filtrate；Filtrate is stopped at a temperature of 62-65 DEG C when vacuum alcohol extracting, ad pond om 60%
Concentration, is made mixture B；
3）Mixture A is mixed evenly with mixture B, is stirred at a temperature of 88-90 DEG C to dry and produces medicine.
Another object of the present invention is to provide application of the medicine in treatment calculus medicine is prepared.
It is used as further scheme of the invention：The calculus is kidney stone.
Kaempferia galanga has cold dispelling, dries, warm taste, wards off the function of bad odor.
Waras have dispelling wind and eliminating dampness, stimulate the circulation of the blood and cause the muscles and joints to relax, strengthen muscles and bones, the effect such as anti-inflammatory analgetic.
Radix Stellariae Yunnanensis has strengthening spleen and nourishing blood, liver-kidney tonifying, the effect of detumescence.Anaemia is cured mainly, spirit is deficient, the dizzy heart
Unbearably, under tinnitus dim eyesight, hectic fever, seminal emission, irregular menstruation, band, fracture, the illness such as mastitis.
The effect of aleppo avens herb has clearing heat and detoxicating, promoting blood circulation and stopping pain, adjusting meridian and stopping leukorrhea.Cure mainly sore, carbuncle and painful swelling, aphtha pharyngalgia,
Under injuries from falls as well, arthralgia pain due to rheumatism, diarrhea dysentery abdominal pain, irregular menstruation, uterine bleeding band, tinea pedis oedema, child convulsion.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention calculus is worked after with comminuted discharge, strengthen immune function of human body and resistance against diseases, have pole for calculus
Good curative effect, total effective rate is up to more than 98%.Medicine of the present invention not only has after significant curative effect, and healing not to kidney stone
Recurrence, has no side effect safely, can reach wide popularization and application on the purpose treated both principal and secondary aspect of disease, clinic.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of medicine for treating calculus is made up of the raw material below according to parts by weight：30 parts of Kaempferia galanga, thousand
Jin pull out 7 parts, 21 parts of Radix Stellariae Yunnanensis, 13 parts of aleppo avens herb.
Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crush, cross 60 mesh sieves, the volume fraction of the two 9 times of quality is added
75% alcohol reflux is extracted 3 times, each 3.3h, merges extract solution, is concentrated, and is dried, is obtained mixture A.By Kaempferia galanga and waras
Ultramicro grinding is carried out to 400 mesh；Add stirring dipping 30h at 7 times of weight, 40 degree of white wine, 55 DEG C；Filter to take filtrate；Filtrate is existed
Vacuum alcohol extracting at a temperature of 62 DEG C, stops concentration during ad pond om 60%, mixture B is made.Mixture A is mixed with mixture B
Stir, stirred at a temperature of 88 DEG C to dry and produce medicine.
Embodiment 2
In the embodiment of the present invention, a kind of medicine for treating calculus is made up of the raw material below according to parts by weight：40 parts of Kaempferia galanga, thousand
Jin pull out 15 parts, 29 parts of Radix Stellariae Yunnanensis, 21 parts of aleppo avens herb.
Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crush, cross 100 mesh sieves, the volume fraction of the two 9 times of quality is added
75% alcohol reflux is extracted 3 times, each 3.3h, merges extract solution, is concentrated, and is dried, is obtained mixture A.By Kaempferia galanga and waras
Ultramicro grinding is carried out to 500 mesh；Add stirring dipping 33h at 8 times of weight, 50 degree of white wine, 55-58 DEG C；Filter to take filtrate；Will filter
Liquid vacuum alcohol extracting at a temperature of 65 DEG C, stops concentration during ad pond om 60%, mixture B is made.By mixture A and mixture B
It is mixed evenly, is stirred at a temperature of 90 DEG C to dry and produce medicine.
Embodiment 3
In the embodiment of the present invention, a kind of medicine for treating calculus is made up of the raw material below according to parts by weight：32 parts of Kaempferia galanga, thousand
Jin pull out 9 parts, 23 parts of Radix Stellariae Yunnanensis, 15 parts of aleppo avens herb.
Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crush, cross 80 mesh sieves, the volume fraction of the two 9 times of quality is added
75% alcohol reflux is extracted 3 times, each 3.3h, merges extract solution, is concentrated, and is dried, is obtained mixture A.By Kaempferia galanga and waras
Ultramicro grinding is carried out to 500 mesh；Add stirring dipping 32h at 7.5 times of weight 40-50 degree white wine, 56 DEG C；Filter to take filtrate；Will
Filtrate vacuum alcohol extracting at a temperature of 63 DEG C, stops concentration during ad pond om 60%, mixture B is made.By mixture A and mixture
B is mixed evenly, and is stirred at a temperature of 89 DEG C to dry and produces medicine.
Embodiment 4
In the embodiment of the present invention, a kind of medicine for treating calculus is made up of the raw material below according to parts by weight：38 parts of Kaempferia galanga, thousand
Jin pull out 13 parts, 27 parts of Radix Stellariae Yunnanensis, 19 parts of aleppo avens herb.
Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crush, cross 80 mesh sieves, the volume fraction of the two 9 times of quality is added
75% alcohol reflux is extracted 3 times, each 3.3h, merges extract solution, is concentrated, and is dried, is obtained mixture A.By Kaempferia galanga and waras
Ultramicro grinding is carried out to 500 mesh；Add stirring dipping 32h at 7.5 times of weight 40-50 degree white wine, 56 DEG C；Filter to take filtrate；Will
Filtrate vacuum alcohol extracting at a temperature of 63 DEG C, stops concentration during ad pond om 60%, mixture B is made.By mixture A and mixture
B is mixed evenly, and is stirred at a temperature of 89 DEG C to dry and produces medicine.
Embodiment 5
In the embodiment of the present invention, a kind of medicine for treating calculus is made up of the raw material below according to parts by weight：35 parts of Kaempferia galanga, thousand
Jin pull out 11 parts, 25 parts of Radix Stellariae Yunnanensis, 17 parts of aleppo avens herb.
Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crush, cross 80 mesh sieves, the volume fraction of the two 9 times of quality is added
75% alcohol reflux is extracted 3 times, each 3.3h, merges extract solution, is concentrated, and is dried, is obtained mixture A.By Kaempferia galanga and waras
Ultramicro grinding is carried out to 500 mesh；Add stirring dipping 32h at 7.5 times of weight 40-50 degree white wine, 56 DEG C；Filter to take filtrate；Will
Filtrate vacuum alcohol extracting at a temperature of 63 DEG C, stops concentration during ad pond om 60%, mixture B is made.By mixture A and mixture
B is mixed evenly, and is stirred at a temperature of 89 DEG C to dry and produces medicine.
The toxicity test of embodiment 6
It is (every that the medicine of the embodiment of the present invention 5 presses 10.0mg/kg, 20.0mg/kg and 40.0mg/kg continuous use 15 weeks to mouse
It is 2 times) and be discontinued 3 weeks after, as a result show：Medicine of the present invention to the hair of rat, behavior, stool and urine, body weight, organ weights,
The indexs such as blood picture, hepatic and renal function, blood glucose, blood fat have no significant effect, and internal organs naked eyes do not find difference change and histology inspection
Come to an end fruit show, medication 15 weeks and be discontinued 3 weeks after, each internal organs of rat without substantially changes.Illustrate medicine of the present invention to rat length
Small toxicity after phase medication, also without abnormal reaction after drug withdrawal, using safety.
Clinical efficacy of the medicine of the present invention of embodiment 7 to kidney stone
Experiment material：Medicine prepared by the embodiment of the present invention 5.
1st, case and method
Kidney stone patient totally 125, male 65, women 60, the age is at 17-68 Sui.Kidney stone diagnostic criteria：Lower abdomen and a left side
Right lumbar region distending pain or involve sample Acute Pain, slight illness position, waist can not unfold, hematuria, painful urination, can not arrange urine etc..
Doctor trained in Western medicine B ultrasound is diagnosed as kidney stone, and calculus diameter is more than 0.1 centimetre, and regular shape, surface is smooth, and with renal plevis kidney calices without glutinous
Intracavitary person even is free on, the urinary tract is without obvious deformity, narrow and infection, the fair person of renal function.
Usage and dosage：The medicine of the embodiment of the present invention 5,3 times a day, each 0.5g, orally；30d is 1 course for the treatment of, is used in conjunction 3
The course for the treatment of.
2nd, efficacy determination
It is defined according to clinical symptom disappearance, is divided into recovery from illness, effective, invalid.
Recovery from illness：Clinical symptom and sign disappears, and recovers normal, pain disappears, urination is normal, indices recover just on inspection
Often, B ultrasound confirms calculus discharge.
It is effective：Clinical symptom and sign substantially or mostly disappears, and pain disappears substantially, and urination is not slightly smooth, on inspection greatly
Part index number recovers normal, and B ultrasound confirms the discharge of calculus part.
It is invalid：Clinical symptom and sign is not improved without improvement, Index for examination, and B ultrasound is confirmed before calculus position, quantity and treatment
Contrast is without substantially change.
3rd, efficacy result is as shown in table 1.
Table 1
Kidney stone early stage patient it is efficient up to 100%, mid-term patient's is efficient up to 100%, and the effective percentage of patients with terminal is
98%.Treat after a course for the treatment of, the symptom of 120 patients has been alleviated, wherein one course for the treatment of of early stage patient basic need, and in
Patients with terminal needs the 2-3 course for the treatment of.
Model case：
1st, Song, female, 39 years old.Symptom is pain in the back, feverishness in palms and soles, hectic fever, night sweat, is 0.7cm through hospital's ultrasound diagnosis kidney stone.
Take and cured after embodiment 5 medicine, 3 courses for the treatment of, follow-up is without recurrence.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It may be appreciated other embodiment.
Claims (6)
1. a kind of medicine for treating calculus, it is characterised in that be made up of the raw material below according to parts by weight：30-40 parts of Kaempferia galanga, thousand
Jin pull out 7-15 parts, 21-29 parts of Radix Stellariae Yunnanensis, 13-21 parts of aleppo avens herb.
2. the medicine for the treatment of calculus according to claim 1, it is characterised in that be made up of the raw material below according to parts by weight：
32-38 parts of Kaempferia galanga, 9-13 parts of waras, 23-27 parts of Radix Stellariae Yunnanensis, 15-19 parts of aleppo avens herb.
3. the medicine for the treatment of calculus according to claim 1, it is characterised in that be made up of the raw material below according to parts by weight：
35 parts of Kaempferia galanga, 11 parts of waras, 25 parts of Radix Stellariae Yunnanensis, 17 parts of aleppo avens herb.
4. a kind of prepare the method that calculus medicine is treated described in claim 1, it is characterised in that comprises the following steps：
1）Radix Stellariae Yunnanensis, aleppo avens herb are mixed, crush, cross 60-100 mesh sieves, the volume fraction of the two 9 times of quality is added
75% alcohol reflux is extracted 3 times, each 3.3h, merges extract solution, is concentrated, and is dried, is obtained mixture A；
2）Kaempferia galanga and waras are subjected to ultramicro grinding to 400-500 mesh；Add 7-8 times of weight 40-50 degree white wine, 55-58 DEG C
Lower stirring dipping 30-33h；Filter to take filtrate；Filtrate is stopped at a temperature of 62-65 DEG C when vacuum alcohol extracting, ad pond om 60%
Concentration, is made mixture B；
3）Mixture A is mixed evenly with mixture B, is stirred at a temperature of 88-90 DEG C to dry and produces medicine.
5. application of the medicine in treatment calculus medicine is prepared as described in claim 1-3 is any.
6. application of the medicine according to claim 5 in treatment calculus medicine is prepared, it is characterised in that the calculus is
Kidney stone.
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| CN201710183781.6A CN106975044A (en) | 2017-03-24 | 2017-03-24 | It is a kind of to treat medicine of calculus and its preparation method and application |
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| CN201710183781.6A CN106975044A (en) | 2017-03-24 | 2017-03-24 | It is a kind of to treat medicine of calculus and its preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111346192A (en) * | 2020-04-09 | 2020-06-30 | 单鹏翼 | Formula and preparation process of medicine for treating calculus |
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| CN103705797A (en) * | 2013-12-17 | 2014-04-09 | 陈中元 | Drug for treating kidney stones |
| CN103751709A (en) * | 2013-12-31 | 2014-04-30 | 青岛恒波仪器有限公司 | Traditional Chinese medicinal composition for treating chloasma and preparation method thereof |
| CN104013681A (en) * | 2014-07-01 | 2014-09-03 | 广西浦北华之源中药饮片有限公司 | Pharmaceutical composition for treating kidney stone |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705797A (en) * | 2013-12-17 | 2014-04-09 | 陈中元 | Drug for treating kidney stones |
| CN103751709A (en) * | 2013-12-31 | 2014-04-30 | 青岛恒波仪器有限公司 | Traditional Chinese medicinal composition for treating chloasma and preparation method thereof |
| CN104013681A (en) * | 2014-07-01 | 2014-09-03 | 广西浦北华之源中药饮片有限公司 | Pharmaceutical composition for treating kidney stone |
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| 李顺民: "《李顺民中医心录》", 31 May 2014, 海天出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111346192A (en) * | 2020-04-09 | 2020-06-30 | 单鹏翼 | Formula and preparation process of medicine for treating calculus |
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Application publication date: 20170725 |