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CN106924470A - 一种用于治疗高脂血症的丸剂药物及其制备方法 - Google Patents

一种用于治疗高脂血症的丸剂药物及其制备方法 Download PDF

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CN106924470A
CN106924470A CN201710186941.2A CN201710186941A CN106924470A CN 106924470 A CN106924470 A CN 106924470A CN 201710186941 A CN201710186941 A CN 201710186941A CN 106924470 A CN106924470 A CN 106924470A
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hyperlipidemia
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罗倩茹
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Chengdu Hai Qing Biological Science And Technology Co Ltd
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Abstract

本发明属于中药制剂领域，目的是根据中医对高脂血症的认识机理而提供的一种用于治疗高脂血症的丸剂药物，所述药物的各个组分及其质量份比如下：全瓜蒌200g、胆南星95g、法半夏95g、菊花85g、泽泻200g、茯苓200g、钩藤230g、生山楂100g、制何首乌200g、金樱子115g、桑寄生120g、丹参120g、草决明120g、黄芪260g、合欢皮120g、荷叶95g、绞骨兰120g、赤芍95g；本发明提供的药物是一个标本兼治的中药组方。

Description

一种用于治疗高脂血症的丸剂药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种用于治疗高脂血症的丸剂药物，特别是供高脂血症患者使用的丸剂药物及其制备方法的领域。
背景技术
医者认为：高脂血症为血脂代谢发生紊乱，脂肪代谢或转运异常，血浆中一种或几种脂质浓度异常者，以头昏、头晕、头痛、胸闷胸痛、腹胀、肥胖等为主的一种脂类代谢过剩性疾病。本病为临床常见病、多发病，又是引发心脑血管疾病的重要因素。随着我国人民生活水平的提高，饮食结构和生活方式的变化，本病的发病率呈逐年上升趋势。目前用于治疗高血脂症的西药大多副作用大，对肝肾有损伤，而中药治疗高脂血症效果缓慢，无法满足临床需要。
那么，就如何找到一种可有效治疗高脂血症的药物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗高脂血症上，人们逐渐意识到了中医治疗高脂血症的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗高脂血症的现状，本发明的目的是在于提供一种用于治疗高脂血症的丸剂药物，以解决高脂血症患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述高脂血症。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种用于治疗高脂血症的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌100～260g、胆南星50～120g、法半夏30～120g、菊花50～100g、泽泻100～250g、茯苓150～260g、钩藤60～300g、生山楂100～150g、制何首乌100～260g、金樱子60～150g、桑寄生100～160g、丹参80～160g、草决明80～160g、黄芪150～360g、合欢皮100～160g、荷叶30～120g、绞骨兰60～160g、赤芍50～120g。
一种用于治疗高脂血症的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌115～230g、胆南星60～105g、法半夏40～105g、菊花60～95g、泽泻115～220g、茯苓170～230g、钩藤70～260g、生山楂115～130g、制何首乌115～230g、金樱子70～130g、桑寄生115～140g、丹参90～140g、草决明90～140g、黄芪170～310g、合欢皮115～140g、荷叶40～105g、绞骨兰70～140g、赤芍60～105g。
一种用于治疗高脂血症的丸剂药物及其制备方法，其特征在于，所述“最佳方案”的药物的各个组分及其质量份比如下所示：
全瓜蒌200g、胆南星95g、法半夏95g、菊花85g、泽泻200g、茯苓200g、钩藤230g、生山楂100g、制何首乌200g、金樱子115g、桑寄生120g、丹参120g、草决明120g、黄芪260g、合欢皮120g、荷叶95g、绞骨兰120g、赤芍95g。
一种用于治疗高脂血症的丸剂药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比共研为极细末待用；
B、按照传统制备中药水丸剂的方法，将研磨好的极细末药物过筛后，放入药器中混合拌均，然后制备成水丸剂（其水丸的粒度为：4.8mm～5.0mm），进而晒干，分装密封即可。
一种用于治疗高脂血症的丸剂药物及其制备方法，其特征在于，所述服用方法为：将制备好的水丸剂药物以每日二次服用，早晚各服一次，给药量11g /次，温开水送下。服药28～42 天后，血脂恢复正常，病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
全瓜蒌，性味：甘、寒，具有清肺化痰、利气宽胸、润肺化痰、滑肠通便、散结消肿之功效，用于治疗痰热咳嗽、胸痹、结胸、胸膈痞痛、肠燥便秘、肺痈、乳痈等症；
胆南星，性味：味苦、性凉，具有清火化痰、镇惊定痼之功效，用于治疗中风痰迷、惊风癫痫、痰火喘嗽、头风眩晕；
法半夏，性味：辛、温，具有燥湿化痰之功效，用于治疗痰多咳喘、痰饮眩悸、风痰眩晕、痰厥头痛等症；
菊花，性味：甘、苦、微寒，具有散风清热、平肝明目之功效，用于治疗风热感冒、头痛眩晕、目赤肿痛、眼目昏花；
泽泻，性味：味甘、淡、性寒，具有利水渗湿、泄热通淋之功效，用于治疗小便不利、热淋涩痛、水肿胀满、泄泻、痰饮眩晕、遗精等症；
茯苓，性味：甘、淡、平，具有渗湿利水、健脾和胃、宁心安神之功效，用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊；
钩藤，性味：甘苦、微寒，具有清热平肝、熄风止痉之功效，用于治疗小儿惊风、夜啼、热盛动风、子痫、肝阳眩晕、肝火头胀痛等症；
生山楂，性味：消食健胃，行气散瘀。用于肉食积滞、胃烷胀满、泻痢腹痛、瘀血经闭、产后瘀阻、心腹刺痛、疝气疼痛、高血脂症等症；
制何首乌，性味：苦、甘、涩、温，具有补肝肾、益精血、乌须发、强筋骨之功效，用于治疗血虚萎黄、眩晕耳鸣、须发早白、腰膝酸软、肢体麻木、崩漏带下、久疟体虚、高血脂；
金樱子，性味：酸、甘、涩、平，具有固精缩尿，涩肠止泻之功效，用于治疗遗精滑精、遗尿尿频、崩漏带下、久泻久痢；
桑寄生，性味：苦、甘、性平，具有补肝肾、强筋骨、祛风湿、安胎之功效，用于治疗腰膝酸痛、筋骨痿弱、肢体偏枯、风湿痹痛、头错目眩、胎动不安、崩漏下血；
丹参，性味：味苦、性微寒，具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效，用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、症瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒；
草决明，性味：苦甘、凉，具有清肝、明目、利水、通便之功效，用于治疗风热赤眼、青盲、雀目、高血压、肝炎、肝硬化腹水、习惯性便秘；
黄芪，性味：甘、微温，具有补气固表、利尿托毒、排脓、敛疮生肌之功效，用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病；
合欢皮，性味：甘、平，具有安神解郁、活血消痈之功效，用于治疗心神不安、忧郁、不眠、内外痈疡、跌打损伤；
荷叶，性味：苦、平，具有清热解暑、升发清阳、凉血止血之功效，用于治疗暑热烦渴、暑湿泄泻、脾虚泄泻、血热吐衄、便血崩漏，荷叶炭收涩化瘀止血，用于多种出血症及产后血晕；
绞骨兰，性味：味苦、性寒，无毒，具有消炎解毒、止咳祛痰之功效，用于治疗慢性气管炎；
赤芍，性味：苦、微寒，具有清热凉血、活血祛瘀之功效，用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤。
本发明药物是基于中医治疗高脂血症的原则，从依据高脂血症的病理机制及药理作用认为：就高脂血症，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述高脂血症的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种用于治疗高脂血症的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌200g、胆南星95g、法半夏95g、菊花85g、泽泻200g、茯苓200g、钩藤230g、生山楂100g、制何首乌200g、金樱子115g、桑寄生120g、丹参120g、草决明120g、黄芪260g、合欢皮120g、荷叶95g、绞骨兰120g、赤芍95g。
实施例2：
一种用于治疗高脂血症的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌230g、胆南星105g、法半夏105g、菊花95g、泽泻220g、茯苓230g、钩藤260g、生山楂130g、制何首乌230g、金樱子130g、桑寄生140g、丹参140g、草决明140g、黄芪310g、合欢皮140g、荷叶105g、绞骨兰140g、赤芍105g。
实施例3：
一种用于治疗高脂血症的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌260g、胆南星120g、法半夏120g、菊花100g、泽泻250g、茯苓260g、钩藤300g、生山楂150g、制何首乌260g、金樱子150g、桑寄生160g、丹参160g、草决明160g、黄芪360g、合欢皮160g、荷叶120g、绞骨兰160g、赤芍120g。
典型病例
经临床诊断治疗高脂血症患者共1065例，年龄为61岁以上的635例，只有430例为61岁以下。1065例患者中痊愈的900例，有效的165例，总有效率达100%。

Claims (3)

1.一种用于治疗高脂血症的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌100～260g、胆南星50～120g、法半夏30～120g、菊花50～100g、泽泻100～250g、茯苓150～260g、钩藤60～300g、生山楂100～150g、制何首乌100～260g、金樱子60～150g、桑寄生100～160g、丹参80～160g、草决明80～160g、黄芪150～360g、合欢皮100～160g、荷叶30～120g、绞骨兰60～160g、赤芍50～120g。
2.根据权利要求1所述的用于治疗高脂血症的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌115～230g、胆南星60～105g、法半夏40～105g、菊花60～95g、泽泻115～220g、茯苓170～230g、钩藤70～260g、生山楂115～130g、制何首乌115～230g、金樱子70～130g、桑寄生115～140g、丹参90～140g、草决明90～140g、黄芪170～310g、合欢皮115～140g、荷叶40～105g、绞骨兰70～140g、赤芍60～105g。
3.根据权利要求1至2所述的用于治疗高脂血症的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
全瓜蒌200g、胆南星95g、法半夏95g、菊花85g、泽泻200g、茯苓200g、钩藤230g、生山楂100g、制何首乌200g、金樱子115g、桑寄生120g、丹参120g、草决明120g、黄芪260g、合欢皮120g、荷叶95g、绞骨兰120g、赤芍95g。
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CN1329893A (zh) * 2000-06-16 2002-01-09 杨传平 一种降脂减肥中药及其制备方法
WO2006081739A1 (fr) * 2005-02-06 2006-08-10 Xinfu Guo Composition servant à traiter ou à prévenir l'hyperlipémie, l'hypertension ou l'infiltration lipidique hépatique
CN103341035A (zh) * 2013-06-27 2013-10-09 刁吉祥 柴胡降脂汤
CN103463426A (zh) * 2013-09-03 2013-12-25 陈柏林 一种治疗高脂血症的中药丸剂

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1329893A (zh) * 2000-06-16 2002-01-09 杨传平 一种降脂减肥中药及其制备方法
WO2006081739A1 (fr) * 2005-02-06 2006-08-10 Xinfu Guo Composition servant à traiter ou à prévenir l'hyperlipémie, l'hypertension ou l'infiltration lipidique hépatique
CN103341035A (zh) * 2013-06-27 2013-10-09 刁吉祥 柴胡降脂汤
CN103463426A (zh) * 2013-09-03 2013-12-25 陈柏林 一种治疗高脂血症的中药丸剂

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