CN106806249A - A kind of skin cream containing grape pip ginkgo biloba p.e and preparation method thereof - Google Patents
A kind of skin cream containing grape pip ginkgo biloba p.e and preparation method thereof Download PDFInfo
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- CN106806249A CN106806249A CN201610933590.2A CN201610933590A CN106806249A CN 106806249 A CN106806249 A CN 106806249A CN 201610933590 A CN201610933590 A CN 201610933590A CN 106806249 A CN106806249 A CN 106806249A
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- Prior art keywords
- grape pip
- ginkgo biloba
- phases
- skin cream
- ginkgo
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Links
- 235000009754 Vitis X bourquina Nutrition 0.000 title claims abstract description 93
- 235000012333 Vitis X labruscana Nutrition 0.000 title claims abstract description 93
- 235000014787 Vitis vinifera Nutrition 0.000 title claims abstract description 93
- 235000008100 Ginkgo biloba Nutrition 0.000 title claims abstract description 45
- 239000002884 skin cream Substances 0.000 title claims abstract description 35
- 244000194101 Ginkgo biloba Species 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 240000006365 Vitis vinifera Species 0.000 title 1
- 241000219095 Vitis Species 0.000 claims abstract description 92
- 239000008367 deionised water Substances 0.000 claims abstract description 20
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000004480 active ingredient Substances 0.000 claims abstract description 10
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- 229940085262 cetyl dimethicone Drugs 0.000 claims abstract description 8
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 8
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 150000002515 isoflavone derivatives Chemical class 0.000 claims abstract description 8
- 235000008696 isoflavones Nutrition 0.000 claims abstract description 8
- 239000002502 liposome Substances 0.000 claims abstract description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940057910 shea butter Drugs 0.000 claims abstract description 8
- 229920005573 silicon-containing polymer Polymers 0.000 claims abstract description 8
- 239000002562 thickening agent Substances 0.000 claims abstract description 8
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011782 vitamin Substances 0.000 claims abstract description 8
- 229930003231 vitamin Natural products 0.000 claims abstract description 8
- 229940088594 vitamin Drugs 0.000 claims abstract description 8
- 235000013343 vitamin Nutrition 0.000 claims abstract description 8
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 8
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 6
- 239000000284 extract Substances 0.000 claims description 43
- 241000218628 Ginkgo Species 0.000 claims description 24
- 235000011201 Ginkgo Nutrition 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 15
- 239000003208 petroleum Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 239000011347 resin Substances 0.000 claims description 12
- 229920005989 resin Polymers 0.000 claims description 12
- 235000019441 ethanol Nutrition 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 230000001804 emulsifying effect Effects 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- DUFKCOQISQKSAV-UHFFFAOYSA-N Polypropylene glycol (m w 1,200-3,000) Chemical class CC(O)COC(C)CO DUFKCOQISQKSAV-UHFFFAOYSA-N 0.000 claims description 7
- 150000001298 alcohols Chemical class 0.000 claims description 7
- 235000002532 grape seed extract Nutrition 0.000 claims description 5
- 229940087603 grape seed extract Drugs 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 239000001717 vitis vinifera seed extract Substances 0.000 claims description 5
- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 230000001351 cycling effect Effects 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims description 4
- 229940031674 laureth-7 Drugs 0.000 claims description 4
- 229920002401 polyacrylamide Polymers 0.000 claims description 4
- 229920000193 polymethacrylate Polymers 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 230000002087 whitening effect Effects 0.000 abstract description 4
- 230000007547 defect Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 abstract 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 abstract 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 abstract 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 abstract 1
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 230000005670 electromagnetic radiation Effects 0.000 description 5
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- 230000006872 improvement Effects 0.000 description 4
- -1 oxygen radical Chemical class 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 244000018633 Prunus armeniaca Species 0.000 description 2
- 235000009827 Prunus armeniaca Nutrition 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 235000020603 homogenised milk Nutrition 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of skin cream, more particularly to grape pip ginkgo biloba p.e skin cream and preparation method thereof.It includes following components：A phases：Ceteareth 21 0.1 5%, cetostearyl alcohol 1 5%, caprylic/capric triglyceride 5 15%, dimethyl silicone polymer 0.1 5%, cetyl dimethicone 0.1 2%, liposomes vitamin e1 10%；B phases：The dipropylene glycol 1 10% of shea butter 5 15%；The assistant for emulsifying agent 1 5% of isoflavones 0.1 5%；C phases：The grape pip ginkgo biloba p.e 3 15% of thickener 1 10%.Remaining material is deionized water.By using grape pip ginkgo biloba p.e, and it is equipped with various effective ingredients, overcome the defect that active ingredient is more easily damaged when grape pip ginkgo biloba p.e is difficult to be absorbed and be made skin cream in the prior art, improve grape pip ginkgo biloba p.e decentralization in skin cream, and obtained skin cream is stable in properties, can give full play to moisturizing, whitening, crease-resistant function.
Description
Technical field
The present invention relates to a kind of skin cream, more particularly to grape pip-ginkgo biloba p.e skin cream and preparation method thereof.
Background technology
With the development in epoch, especially urban woman is most in sealing and air conditioner surroundings and more for modern female
Ground is in radiation environment as in the environment of computer screen.It refers to just electromagnetic radiation that computer radiation is main, and electromagnetic radiation is usual
With fuel factor, non-thermal effect and stimulation produce biological agent to body.Computer comes to the hidden danger of human health from emission types
See, the main electromagnetic radiation (various electromagnetic radiations and electromagnetic wave etc.) for operationally being produced including computer and being sent, sound (noise),
Various radiation " pollution " such as light (ultraviolet, infrared radiation and visible ray etc.), Long Term Contact electromagnetic radiation can produce skin
Give birth to early ageing, the negative effect such as spot occur；And during the dehumidifier of air-conditioning so that body water is constantly evaporated, even if by mending
Fill drinking-water, it is also difficult to even if making up the loss of moisture of skin.Therefore, dry skin and mistake are exposed to radiation environment for a long time, into
For the main skin health that most women face in daily life is threatened.
At home and abroad cosmetic field, it is crease-resistant and whitening type skin care item to pay close attention at present more, and for being applicable
In daily skin radiation-preventing and dry then less, although sun screen has certain obstruct to make for the negative effect of external environment condition
With, but sun screen when mostly more stimulating the dense chemicals modulation of smell form, commonly using being unfavorable for human skin
Natural health.Therefore on the premise of product functionality is ensured, consumer more has a mind to purchase addition natural material, instead of artificial
Synthesize the cosmetics of chemical composition.
The content of the invention
The present invention is equipped with various effective ingredients by using grape pip-ginkgo biloba p.e, is prepared into grape pip-silver
Apricot leaf extract skin cream, can overcome grape pip-ginkgo biloba p.e to be in the prior art difficult to be absorbed and be made skin cream
When the defect that is more easily damaged of active ingredient, improve grape pip-ginkgo biloba p.e decentralization in skin cream, and obtained profit
Skin frost is stable in properties, can give full play to moisturizing, whitening, crease-resistant function.
One of the object of the invention is to provide the formula of the grape pip-ginkgo biloba p.e skin cream.
The two of the object of the invention are to provide the grape pip-ginkgo biloba p.e skin cream preparation method.
A kind of skin cream containing grape pip-ginkgo biloba p.e, count by weight percentage, it includes following components：
A phases：
The 0.1-5% cetostearyl alcohols of ceteareth -21 1-5%
Caprylic/capric triglyceride 5-15% dimethyl silicone polymers 0.1-5%
Cetyl dimethicone 0.1-2% liposomes vitamin Es 1-10%
B phases：
Shea butter 5-15% dipropylene glycols 1-10%
Isoflavones 0.1-5% assistant for emulsifying agents 1-5%
C phases：
Thickener 1-10% grape pips-ginkgo biloba p.e 3-15%
Described grape pip-ginkgo biloba p.e is that content ratio is 1-2 respectively:The grape seed extract of 3-5 is carried with ginkgo leaf
Take the mixed extract of thing；
Remaining material is deionized water.
Used as improvement, the grape pip-ginkgo biloba p.e skin cream can also be produced using formula as below：
A phases：
The 0.5-2% cetostearyl alcohols of ceteareth -21 2-4%
Caprylic/capric triglyceride 8-12% dimethyl silicone polymers 1-3%
Cetyl dimethicone 0.8-1.2% liposomes vitamin Es 4-8%
B phases：
Shea butter 8-12% dipropylene glycols 4-7%
Isoflavones 0.5-1.5% assistant for emulsifying agents 2-4%
C phases：
Thickener 4-7% grape pips-ginkgo biloba p.e 5-10%
Preservative 0.1-0.5% essence 0.1-0.3%
Described grape pip-ginkgo biloba p.e is that content ratio is 1-2 respectively:The grape seed extract of 3-5 is carried with ginkgo leaf
Take the mixed extract of thing；
Remaining material is deionized water.
As a further improvement, described thickener is glycerine polymethacrylates or propane diols；
Described preservative is double（Methylol）In imidazolidinyl urea, methyl hydroxybenzoate, Nipasol one or more
Mixture；
Described assistant for emulsifying agent is polyacrylamide/C13-14 isoparaffins/laureth -7.
The preparation method of the grape pip-ginkgo biloba p.e skin cream is as follows：
（1）Mix A, B two-phase raw material respectively；
（2）The A phases and B phases in addition to assistant for emulsifying agent are heated respectively to 85-95 DEG C, and maintain 20min to sterilize；
（3）When A, B two-phase are cooled to 70-80 DEG C, after B phases are slowly mixed with A phases in 5-15min, 35-40 DEG C is cooled to
And add C phase materials；
（4）Add after deionized water and carry out emulsifying treatment, that is, obtain described grape pip-ginkgo biloba p.e moisturizing
Frost.
After deionized water is added, carried out by way of homogeneous emulsifying machine is below 40 DEG C with 3000-4500r/min
During matter emulsification treatment, the mixing of each component can be made more uniform.
In order that the grape pip-ginkgo biloba p.e skin cream is better, following methods can be used, prepare grape
Seed-ginkgo biloba p.e：
（1）Ginkgo leaf and grape pip are cleaned respectively, after drying, carries out pulverization process, obtain the ginkgo that fineness is 100-200 mesh
Leaf powder and grape pip powder；
（2）By Ginkgo Leaf, grape pip powder concentration for the hydrochloric acid solution of 10-15% is extracted, ginkgo is obtained respectively
Leaf extract and grape pip extract solution；
（3）Ginkgo biloba succi and grape pip extract solution are filtered successively respectively, are cooled down, being stood and centrifugal filtration after, adopt
With macroporous resin column to the active ingredient in absorption ginkgo biloba succi and grape pip extract solution；
（4）Respectively by step（3）The middle macroreticular resin for having adsorbed active ingredient in ginkgo biloba succi and grape pip extract solution, makes
After deionized water rinsing 5-15min, concentration carries out gradient parsing to the macroreticular resin for 70%-80% ethanol, mixing
The desorbed solution that ginkgo biloba succi and grape pip extract solution are extracted, and by mixing desorbed solution by being concentrated to give CE；
（5）Petroleum ether cycling extraction will be added in CE, obtain being mixed with the thin medicinal extract of petroleum ether, then made using revolving method
After obtaining the petroleum ether volatilization in thin medicinal extract, absolute ethyl alcohol to thin medicinal extract is added to be completely dissolved, then cooled down successively, settled,
Centrifugal filtration and concentration, drying, are obtained grape pip-ginkgo biloba p.e.
Contain substantial amounts of OPC in grape pip, it has very strong activity in vivo.It is demonstrated experimentally that OPC
Green Tea Extract oxidability is 50 times of vitamin E, ascorbic 20 times, can effectively remove free radical unnecessary in vivo, protection
Human cell tissue prevents and treats the kind more than 100 such as allergy, cancer, aging disease relevant with free radical from the oxidative damage of free radical
Disease, also with reinforcement and protection human body active mass, stabilizing cell membrane and antienzyme activity（Histamine decarboxylase）Etc. biological nature.
Additionally, OPC possesses good bioavilability, it is easy to be absorbed by the body；
Because endocrine disturbance, the oxygen radical lacked of proper care and cause are excessive, make internal superoxide dismutase (SOD) not enough, lead
Cause excessive oxygen radical that the reaction of oxidation is produced with corium confluent monolayer cells, form substantial amounts of lipofuscin (lipid peroxide), cause
Chloasma or cyasma.Contained flavone component can hinder formation and calmness of the pigment in skin corium in ginkgo leaf, reach
To skin whitening and the effect for preventing and treating pigment patch.In addition to flavones, the trace element such as manganese, molybdenum in ginkgo leaf also can be clear
Except oxygen radical and suppression melanin growth.
Specific embodiment
The present invention is specifically described with reference to embodiment, the present invention also can be by other essence without departing from its spirit
Or the embodiment of essential feature is realized.Therefore, embodiment below, is merely illustrative, and is not only, Suo You
Change in the scope of the invention or in equivalent the scope of the present invention and be included in the invention.
Embodiment 1
A kind of skin cream containing grape pip-ginkgo biloba p.e, count by weight percentage, it includes following components：
A phases：
The 0.1-5% cetostearyl alcohols of ceteareth -21 1-5%
Caprylic/capric triglyceride 5-15% dimethyl silicone polymers 0.1-5%
Cetyl dimethicone 0.1-2% liposomes vitamin Es 1-10%
B phases：
Shea butter 5-15% dipropylene glycols 1-10%
Isoflavones 0.1-5% assistant for emulsifying agents 1-5%
C phases：
Thickener 1-10% grape pips-ginkgo biloba p.e 3-15%
Described grape pip-ginkgo biloba p.e is commercially available grape seed extract and ginkgo biloba p.e by 2:3 ratio is mixed
Conjunction is formed；
Remaining material is deionized water.
The preparation method of the grape pip-ginkgo biloba p.e skin cream is as follows：
（1）Mix A, B two-phase raw material respectively；
（2）The A phases and B phases in addition to assistant for emulsifying agent are heated respectively to 85-95 DEG C, and maintain 20min to sterilize；
（3）When A, B two-phase are cooled to 70-80 DEG C, after B phases are slowly mixed with A phases in 5-15min, 35-40 DEG C is cooled to
And add C phase materials；
（4）Add after deionized water and carry out emulsifying treatment, that is, obtain described grape pip-ginkgo biloba p.e moisturizing
Frost.
Embodiment 2
Used as improvement, the grape pip-ginkgo biloba p.e skin cream can also be produced using formula as below：
A phases：
The 0.5-2% cetostearyl alcohols of ceteareth -21 2-4%
Caprylic/capric triglyceride 8-12% dimethyl silicone polymers 1-3%
Cetyl dimethicone 0.8-1.2% liposomes vitamin Es 4-8%
B phases：
Shea butter 8-12% dipropylene glycols 4-7%
Isoflavones 0.5-1.5% polyacrylamides 1-2%
The 1-2% of laureth -7
C phases：
Glycerine polymethacrylates 4-7% grape pips-ginkgo biloba p.e 5-10%
It is double（Methylol）Imidazolidinyl urea 0.1-0.5% essence 0.1-0.3%
Remaining material is deionized water.
In the present embodiment, grape pip-ginkgo biloba p.e is produced in the following manner：
（1）Ginkgo leaf and grape pip are cleaned respectively, after drying, carries out pulverization process, obtain the ginkgo that fineness is 100-150 mesh
Leaf powder and grape pip powder；
（2）Ginkgo Leaf, the hydrochloric acid solution that grape pip powder concentration is 10% are extracted, ginkgo leaf is obtained respectively
Extract solution and grape pip extract solution；
（3）Ginkgo biloba succi and grape pip extract solution are filtered successively respectively, are cooled down, being stood and centrifugal filtration after, adopt
With macroporous resin column to the active ingredient in absorption ginkgo biloba succi and grape pip extract solution；
（4）Respectively by step（3）The middle macroreticular resin for having adsorbed active ingredient in ginkgo biloba succi and grape pip extract solution, makes
After deionized water rinsing 8min, concentration carries out gradient parsing to the macroreticular resin for 70% ethanol, and mixing ginkgo leaf is carried
The desorbed solution that liquid and grape pip extract solution are extracted is taken, and by mixing desorbed solution by being concentrated to give CE；
（5）Petroleum ether cycling extraction will be added in CE, obtain being mixed with the thin medicinal extract of petroleum ether, then made using revolving method
After obtaining the petroleum ether volatilization in thin medicinal extract, absolute ethyl alcohol to thin medicinal extract is added to be completely dissolved, then cooled down successively, settled,
Centrifugal filtration and concentration, drying, are obtained grape pip-ginkgo biloba p.e.
The preparation method of the grape pip-ginkgo biloba p.e skin cream is as follows：
（1）Mix A, B two-phase raw material respectively；
（2）The A phases and B phases in addition to assistant for emulsifying agent are heated respectively to 85 DEG C, and maintain 20min to sterilize；
（3）When A, B two-phase are cooled to 75 DEG C, after B phases are slowly mixed with A phases in 15min, it is cooled to 36 DEG C and adds C
Phase material；
（4）After adding deionized water, carried out at emulsifying by way of homogeneous emulsifying machine is below 40 DEG C with 3000r/min
Reason, that is, obtain described grape pip-ginkgo biloba p.e skin cream.
Embodiment 3
In order that the grape pip-ginkgo biloba p.e skin cream is better, following methods can be used, prepare grape pip-silver
Apricot leaf extract：
Embodiment 2
Used as improvement, the grape pip-ginkgo biloba p.e skin cream can also be produced using formula as below：
A phases：
The 0.8-1.5% cetostearyl alcohols of ceteareth -21 2.5-4%
Caprylic/capric triglyceride 8-10.5% dimethyl silicone polymers 1-2.5%
Cetyl dimethicone 0.8-1.0% liposomes vitamin Es 5-7%
B phases：
Shea butter 8-10% dipropylene glycols 4-6%
Isoflavones 0.5-1.5% polyacrylamides 1-2%
The 1-2% of laureth -7
C phases：
Glycerine polymethacrylates 4-6.5% grape pips-ginkgo biloba p.e 5-8%
It is double（Methylol）Imidazolidinyl urea 0.1-0.5% essence 0.1-0.3%
Remaining material is deionized water.
In the present embodiment, grape pip-ginkgo biloba p.e is produced in the following manner：
（1）Ginkgo leaf and grape pip are cleaned respectively, after drying, carries out pulverization process, obtain the ginkgo that fineness is 150-200 mesh
Leaf powder and grape pip powder；
（2）Ginkgo Leaf, the hydrochloric acid solution that grape pip powder concentration is 15% are extracted, ginkgo leaf is obtained respectively
Extract solution and grape pip extract solution；
（3）Ginkgo biloba succi and grape pip extract solution are filtered successively respectively, are cooled down, being stood and centrifugal filtration after, adopt
With macroporous resin column to the active ingredient in absorption ginkgo biloba succi and grape pip extract solution；
（4）Respectively by step（3）The middle macroreticular resin for having adsorbed active ingredient in ginkgo biloba succi and grape pip extract solution, makes
After deionized water rinsing 15min, concentration carries out gradient parsing to the macroreticular resin for 80% ethanol, mixes ginkgo leaf
The desorbed solution that extract solution and grape pip extract solution are extracted, and by mixing desorbed solution by being concentrated to give CE；
（5）Petroleum ether cycling extraction will be added in CE, obtain being mixed with the thin medicinal extract of petroleum ether, then made using revolving method
After obtaining the petroleum ether volatilization in thin medicinal extract, absolute ethyl alcohol to thin medicinal extract is added to be completely dissolved, then cooled down successively, settled,
Centrifugal filtration and concentration, drying, are obtained grape pip-ginkgo biloba p.e.
The preparation method of the grape pip-ginkgo biloba p.e skin cream is as follows：
（1）Mix A, B two-phase raw material respectively；
（2）The A phases and B phases in addition to assistant for emulsifying agent are heated respectively to 90 DEG C, and maintain 20min to sterilize；
（3）When A, B two-phase are cooled to 70-80 DEG C, after B phases are slowly mixed with A phases in 10min, it is cooled to 38 DEG C and adds
Enter C phase materials；
（4）Add after deionized water and carry out emulsifying treatment, that is, obtain described grape pip-ginkgo biloba p.e moisturizing
Frost.
After deionized water is added, homogenized milk is carried out by way of homogeneous emulsifying machine is below 40 DEG C with 4500r/min
When changing treatment, that is, obtain described grape pip-ginkgo biloba p.e skin cream.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any one skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in,
Should all be included within the scope of the present invention.Therefore, protection scope of the present invention should be with scope of the claims
It is defined.
Claims (8)
1. a kind of skin cream containing grape pip-ginkgo biloba p.e, count by weight percentage, it includes following components：
A phases：
The 0.1-5% cetostearyl alcohols of ceteareth -21 1-5%
Caprylic/capric triglyceride 5-15% dimethyl silicone polymers 0.1-5%
Cetyl dimethicone 0.1-2% liposomes vitamin Es 1-10%
B phases：
Shea butter 5-15% dipropylene glycols 1-10%
Isoflavones 0.1-5% assistant for emulsifying agents 1-5%
C phases：
Thickener 1-10% grape pips-ginkgo biloba p.e 3-15%
Described grape pip-ginkgo biloba p.e is that content ratio is 1-2 respectively:The grape seed extract of 3-5 is carried with ginkgo leaf
Take the mixed extract of thing；
Remaining material is deionized water.
2. a kind of skin cream containing grape pip-ginkgo biloba p.e as claimed in claim 1, count by weight percentage, its
Comprising following components：
A phases：
The 0.5-2% cetostearyl alcohols of ceteareth -21 2-4%
Caprylic/capric triglyceride 8-12% dimethyl silicone polymers 1-3%
Cetyl dimethicone 0.8-1.2% liposomes vitamin Es 4-8%
B phases：
Shea butter 8-12% dipropylene glycols 4-7%
Isoflavones 0.5-1.5% assistant for emulsifying agents 2-4%
C phases：
Thickener 4-7% grape pips-ginkgo biloba p.e 5-10%
Preservative 0.1-0.5% essence 0.1-0.3%
Described grape pip-ginkgo biloba p.e is that content ratio is 1-2 respectively:The grape seed extract of 3-5 is carried with ginkgo leaf
Take the mixed extract of thing；
Remaining material is deionized water.
3. a kind of skin cream containing grape pip-ginkgo biloba p.e as claimed in claim 1 or 2, it is characterised in that：
Described thickener is glycerine polymethacrylates or propane diols.
4. a kind of skin cream containing grape pip-ginkgo biloba p.e as claimed in claim 1 or 2, it is characterised in that：
Described preservative is double（Methylol）In imidazolidinyl urea, methyl hydroxybenzoate, Nipasol one or more
Mixture.
5. a kind of skin cream containing grape pip-ginkgo biloba p.e as claimed in claim 1 or 2, it is characterised in that：
Described assistant for emulsifying agent is polyacrylamide/C13-14 isoparaffins/laureth -7.
6. the preparation side of a kind of skin cream containing grape pip-ginkgo biloba p.e as described in claim 1-5 any one
Method, it is characterised in that following steps：
（1）Mix A, B two-phase raw material respectively；
（2）The A phases and B phases in addition to assistant for emulsifying agent are heated respectively to 85-95 DEG C, and maintain 20min to sterilize；
（3）When A, B two-phase are cooled to 70-80 DEG C, after B phases are slowly mixed with A phases in 5-15min, 35-40 DEG C is cooled to
And add C phase materials；
（4）Add after deionized water and carry out emulsifying treatment, that is, obtain described grape pip-ginkgo biloba p.e moisturizing
Frost.
7. the preparation method of a kind of skin cream containing grape pip-ginkgo biloba p.e as described in claim 6 any one,
It is characterized in that following steps：
Described step（4）In, pass through homogeneous emulsifying machine below 40 DEG C with 3000-4500r/min's after adding deionized water
Mode carries out emulsifying treatment.
8. the preparation method of a kind of skin cream containing grape pip-ginkgo biloba p.e as described in claim 6 any one,
It is characterized in that following steps：
The preparation method of described grape pip-ginkgo biloba p.e is as follows：
（1）Ginkgo leaf and grape pip are cleaned respectively, after drying, carries out pulverization process, obtain the ginkgo that fineness is 100-200 mesh
Leaf powder and grape pip powder；
（2）By Ginkgo Leaf, grape pip powder concentration for the hydrochloric acid solution of 10-15% is extracted, ginkgo is obtained respectively
Leaf extract and grape pip extract solution；
（3）Ginkgo biloba succi and grape pip extract solution are filtered successively respectively, are cooled down, being stood and centrifugal filtration after, adopt
With macroporous resin column to the active ingredient in absorption ginkgo biloba succi and grape pip extract solution；
（4）Respectively by step（3）The middle macroreticular resin for having adsorbed active ingredient in ginkgo biloba succi and grape pip extract solution, makes
After deionized water rinsing 5-15min, concentration carries out gradient parsing to the macroreticular resin for 70%-80% ethanol, mixing
The desorbed solution that ginkgo biloba succi and grape pip extract solution are extracted, and by mixing desorbed solution by being concentrated to give CE；
（5）Petroleum ether cycling extraction will be added in CE, obtain being mixed with the thin medicinal extract of petroleum ether, then made using revolving method
After obtaining the petroleum ether volatilization in thin medicinal extract, absolute ethyl alcohol to thin medicinal extract is added to be completely dissolved, then cooled down successively, settled,
Centrifugal filtration and concentration, drying, are obtained grape pip-ginkgo biloba p.e.
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| CN110368468A (en) * | 2019-08-29 | 2019-10-25 | 无限极（中国）有限公司 | A kind of composition and preparation method with antipollution damaging action, application |
| CN112057391A (en) * | 2020-10-22 | 2020-12-11 | 南京泛成生物科技有限公司 | Moisturizing cream and preparation method thereof |
| CN114259417A (en) * | 2020-10-01 | 2022-04-01 | C·扎维拉 | Potent skin hydrating system and method |
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