CN106726866A - A kind of skin-moisturizing, skin cream composition without preservative and preparation method thereof - Google Patents

Abstract

The invention discloses a moisturizing cream composition without preservatives and a preparation method thereof. The moisturizing cream is made of the following components by weight percentage: oily substance 10‑40%, emulsifier 1‑5%, thickener 0.1‑5%, polyol 1‑15%, sodium hyaluronate 001‑ 0.2%, dextran 0.1‑3%, allantoin 0.05‑0.3%, glyceryl caprylate 0.1‑1%, undecylenic acid glyceride 0.1‑2%, EDTA disodium 0.01‑0.2, vegetable composition Extract 0.1‑5%, lactic acid 0.01‑1%, essence 0.01‑0.5%, water as the balance. The moisturizing moisturizer prepared by the invention has a good moisturizing effect, does not contain any preservatives stipulated in the "Safety Technical Specifications for Cosmetics" (2015), is less irritating, and is safer for human bodies.

Description

A preservative-free moisturizing moisturizer composition and preparation method thereof

technical field

The invention relates to a moisturizing cream composition without preservatives and a preparation method thereof, belonging to the field of cosmetics.

Background technique

The use of cosmetics has a long history. Nowadays, with the development of economy and the continuous improvement of people's living standards, cosmetics have become an indispensable part of people's daily life. Most of the cosmetics used by humans in the early days were natural minerals. These substances themselves have antibacterial ability and there is no problem of antisepsis. With the progress of society and the development of science and technology, the raw materials and auxiliary materials of cosmetics are no longer limited to natural substances, but various nutrients are added. The rich nutrients in cosmetics are easily contaminated by microorganisms. In addition, production equipment, External factors such as packaging and storage can also lead to microbial contamination of products. In order to prevent microbial contamination of cosmetics during the shelf life and consumer use period, and reasonably extend the shelf life of products, various cosmetics must add certain preservatives to prevent cosmetics from deteriorating. .

Cosmetic preservatives defined by regulations refer to substances added to cosmetics to inhibit the growth of microorganisms in the cosmetics. The "Safety and Technical Specifications for Cosmetics" (2015) stipulates that the preservatives used in cosmetics must be the substances listed in the specification. Some of these cosmetic preservatives currently used may cause skin irritation and allergic reactions, and some have harmful effects on the environment. relatively large hazard. In recent years, the State Food and Drug Administration has put forward higher and higher requirements for the safety of cosmetics. Safe and non-irritating cosmetics have gradually become the focus of attention. The safety of preservatives used in cosmetics has always been questioned. With the improvement of people's living standards, more and more attention has been paid to the problem of cosmetic allergies. In order to meet the consumption needs of the people, the research on cosmetics without preservatives has become a hot spot.

Contents of the invention

The object of the present invention is to provide a moisturizing cream composition without preservatives and a preparation method thereof.

For achieving the purpose of the present invention, the present invention adopts following technical scheme:

A preservative-free moisturizing moisturizer composition is characterized in that it is made of the following components in weight percentage:

Oily substance 10-40%

Emulsifier 1-5%

Thickener 0.1-5%

Polyol 1-15%

Sodium Hyaluronate 001-0.2%

Dextran 0.1-3%

Allantoin 0.05-0.3%

Glyceryl Caprylate 0.1-1%

Glyceryl Undecylenate 0.1-2%

Disodium EDTA 0.01-0.2

Plant composition extract 0.1-5%

Lactic acid 0.01-1%

Flavor 0.01-0.5%

water balance

The above-mentioned composition, wherein said oily substance is cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, coconut oil-caprylate/caprate, hydrogenated olive oil decyl esters, Dicaprylyl Carbonate, Caprylic/Capric Triglyceride, Shea Butter, Olive Oil, Jojoba Seed Oil, White Pond Seed Oil, Hydrogenated Olive Decyl Esters, Coconut Oil, C14-22 Alcohols, Glyceryl Hard Fatty acid esters, isopropyl palmitate, isopropyl myristate, isononyl isononanoate, tocopheryl acetate, ascorbyl tetraisopalmitate, dimethicone and dimethicone A combination of any three or more of oxyalkanol, cyclomethicone, dioctyl carbonate, mineral oil, and paraffin.

The above-mentioned composition, wherein said emulsifier is C12-20 alkyl glucoside, arachidyl alcohol glucoside, cetearyl glucoside, coconut oil glucoside, polyglycerol-10 pentastearate, cetyl Waxstearyl Olivate, Sorbitan Olivate, Cetyl PEG/PPG-10/1 Dimethicone 2-3%, Lecithin 0.5-1.0%, Methyl Glucose Any one or combination of hemistearate 0.5-1.5%, PEG-10 polydimethylsiloxane, hydrogenated lecithin.

The above-mentioned composition, wherein said thickener carbomer, acrylic acid (ester) type/C10-30 alkanol acrylate cross-linked polymer, xanthan gum, starch, bio-glucose gum-1, pectin, small Any one or combination of Sclerotin, Acacia Gum, and Hydroxyethylcellulose.

The above composition, wherein the polyhydric alcohol is any one or more combinations of glycerin, propylene glycol, butylene glycol, dipropylene glycol, 1,2-pentanediol, sorbitol, polyethylene glycol-8, .

The above-mentioned composition, wherein the plant composition extract is 30-50 parts of Scutellaria baicalensis, 20-45 parts of Piperia chinensis, and 20-45 parts of pomegranate peel made from the following plants by weight. The preparation method is as follows: crush the plants, sieve them with 20-100 mesh sieves, mix them, add the extraction solvent according to the liquid-material mass ratio of 5:1-20:1, soak for 1-5 hours, and extract under the pressure of 10-100MPa Use a high-pressure homogeneous extractor to extract at room temperature. After the extract is centrifuged, it is concentrated with a membrane. The concentrate is adsorbed with a macroporous resin, and then eluted with ethanol with a volume fraction of 10-95%. The eluate is collected. Concentrate the membrane until the mass ratio of the extract to the herbal medicine is 1:0.1-1:5, then add butanediol to dissolve, and filter to obtain a herbal medicine composition; the extraction solvent is water, ethanol or ethanol aqueous solution.

The preservative-free moisturizing cream composition of the present invention does not contain any preservatives specified in the "Safety and Technical Specifications for Cosmetics" (2015).

The preparation method of a kind of preservative-free moisturizing cream composition of the present invention is characterized in that the specific steps are:

(1) Put oily substances, oil-soluble emulsifiers, glycerin caprylate, glyceryl undecylenate and other oil-soluble components into the oil pan and heat to 80°C, stir and mix evenly to dissolve completely, forming the oil phase ,stand-by.

(2) Put water, water-soluble emulsifier, polyol, thickener, sodium hyaluronate, dextran, allantoin, disodium EDTA, lactic acid and other water-soluble components into the emulsification pot and heat to 85°C, Stir and mix evenly to make it completely dissolved, and it is the water phase, which is ready for use.

(3) Control the homogenization speed at 1000-8000r/min, and the stirring speed at 200-500r/min. Quickly put the oil phase into the emulsification pot and homogenize for 3-10 minutes.

(4) Stop homogenization, keep the temperature at 80°C, control the stirring speed at 200-500r/min, and stir for 10 minutes.

(5) Keep the stirring speed at 200-500r/min and cool down.

(6) Cool down to 40°C, add the plant composition extract and essence into the emulsification pot, vacuumize, and stir evenly.

(7) Stir evenly, cool down to 35°C, discharge, fill and seal.

detailed description

The present invention will be further described below through specific examples, but these examples are only for illustration, not limitation of the present invention.

Example 1 Emollient and moisturizing cream (I)

The formula is shown in Table 1.

Table 1

The preparation method is as follows:

(1) Put component A into an oil pan and heat to 80°C, stir and mix evenly to dissolve completely, and set aside.

(2) Put component B into the emulsification pot and heat to 80°C, stir and mix evenly to dissolve completely, and set aside.

(3) Control the homogenization speed at 5000r/min and the stirring speed at 300r/min. Quickly put component A into the emulsification pot and homogenize for 15 minutes.

(4) Stop homogenization, keep the temperature at 80 degrees, stir at 400r/min, and stir for 10 minutes.

(5) Keep the stirring speed at 400r/min and cool down.

(6) Cool down to 40°C, add component C into the emulsification pot, vacuumize, and stir evenly.

(7) Stir evenly, cool down to 35°C, discharge, fill and seal.

Example 2 Emollient and moisturizing cream (Ⅱ)

The formula is shown in Table 2.

Table 2

The preparation method is as follows:

(1) Put component A into an oil pan and heat to 80°C, stir and mix evenly to dissolve completely, and set aside.

(2) Put component B into the emulsification pot and heat to 80°C, stir and mix evenly to dissolve completely, and set aside.

(3) Control the homogenization speed at 5000r/min and the stirring speed at 300r/min. Quickly put component A into the emulsification pot and homogenize for 15 minutes.

(4) Stop homogenization, keep the temperature at 80 degrees, stir at 400r/min, and stir for 10 minutes.

(5) Keep the stirring speed at 400r/min and cool down.

(6) Cool down to 40°C, add component C into the emulsification pot, vacuumize, and stir evenly.

(7) Stir evenly, cool down to 35°C, discharge, fill and seal.

Test Example 1 Moisturizing Efficacy Evaluation Experiment

According to the light industry standard QB/T 4256-2011 Cosmetics Moisturizing Efficacy Evaluation Guide, the moisturizing effect of the moisturizing cream (I) prepared in Example 1 was determined.

1. Experimental principle: The capacitance method is used to measure the moisture content of the stratum corneum of human skin based on the significant difference in the dielectric constant of water and other substances. According to the different moisture content of the stratum corneum of the skin, the capacitance value of the measured skin is different, and its parameters can be Represents skin moisture content.

2. Experimental instrument: Comermeter CM825 (German Courage+Khazaha company

3. Experimental method: 30 healthy volunteers, 20 males and 10 females, aged 25-50. In a constant temperature environment (20~22°C), relative humidity 50±10%, rest for 1 hour. The samples of Example 1 were used respectively, and the amount was (2.0±0.1) mg/㎝2 applied to the inside of the left forearm (3cm×3cm) and the inside of the right forearm (3cm×3cm) of the subject. The blank control (not painted) was tested at the same time. Test the hydration status of the skin at 1 hour, 2 hours, 4 hours, and 6 hours after applying the sample.

4. Experimental results: See Table 3.

table 3

The result shows that the skin moisturizing cream of the present invention has good moisturizing effect and has a long moisturizing time for the skin.

Test Example 2 Anti-corrosion challenge experiment

With the emollient moisturizing cream of the system described in Example 1, common mixed bacteria (staphylococcus aureus SA, escherichia coli EC, pseudomonas aeruginosa PA) and mixed fungi (aspergillus niger AN) in single inoculation cosmetic work , Candida albicans CA), according to the microbial challenge test method of the Cosmetics, Toiletries and Fragrance Association (CTFA), the sample monitoring period is 28 days, during which samples are tested on the 2nd, 7th, 14th and 28th day respectively, and the calculated Colony count (cfu) in mL. The results are shown in Table 4

Table 4 Antibacterial test results

bacteria 0 days 7 days 14 days 21 days 28 days mixed bacteria 3×10 ⁷ 0 0 0 0 mixed fungi 5×10 ⁵ 0 0 0 0

The results in Table 1 show that the emollient and moisturizing cream obtained as described in Example 1 can pass the antiseptic challenge and fully achieve the antiseptic effect.

Test Example 3 Patch Test

With the emollient and moisturizing cream prepared in Example 1, carry out a patch test to test its allergic reaction to the skin, the method is: select a qualified spot tester, apply the sample evenly in the spot tester, and then apply Patient's back, lightly press with the palm to make it evenly attached to the skin, and last for 72 hours. After removing the spot tester of the test substance, wait for 30 minutes, and observe the skin reaction after the indentation disappears. Record the reaction results with reference to the skin reaction grading standards in the "Safety and Technical Specifications for Cosmetics" (2015 edition). Negative control: deionized water. There were 30 subjects in total, 20 males and 10 females. The face trial test results are shown in Table 5.

table 5

Phenomenon itchy skin skin tingling skin redness hot skin other adverse reactions total male 0 0 0 0 0 0 female 0 0 0 0 0 0

The results in Table 5 show that with the emollient and moisturizing cream prepared in Example 1, no allergic phenomenon and adverse reactions occur in the testers.

Claims (7)

1. a kind of skin-moisturizing, skin cream composition without preservative, it is characterised in that：It is made up of the component of following percentage by weight： Oily matter 10-40%, emulsifying agent 1-5%, thickener 0.1-5%, polyalcohol 1-15%, Sodium Hyaluronate 001-0.2%, glucan 0.1-3%, allantoin 0.05-0.3%, glycerol caprylate 0.1-1%, endecatylene acid glyceride 0.1-2%, EDETATE SODIUM 0.01- 0.2, plant composition extract 0.1-5%, lactic acid 0.01-1%, essence 0.01-0.5%, water is surplus；Described one kind is free of The skin-moisturizing, skin cream composition of preservative, does not contain《Cosmetics safety technical specification》（Version in 2015）Any anti-corrosion of defined Agent.

2. the oily matter described in claim 1 be cetanol, stearyl alcohol, cetostearyl alcohol, docosyl alcohol, lauric alcohol-caprylate/ Decylate, hydrogenated olive oil decyl alcohol esters, carbonic acid dioctyl ester, caprylic/capric triglyceride, Butyrospermum parkii fruit fat, olea europaea fruit Oil, jojoba seed oil, white pond flower seed oil, hydrogenated olive oil decyl alcohol esters, coconut oil, C14-22 alcohol, stearine, palm fibre Palmitic acid isopropyl propionate, isopropyl myristate, isononyl isononanoate, tocopherol acetate, Ascorbyl Tetraisopalmitate, poly- two It is any in methylsiloxane and dimethiconol, cyclomethicone, carbonic acid dioctyl ester, mineral oil, paraffin More than three kinds of composition.

3. the emulsifying agent described in claim 1 be C12-20 alkyl glucosides, arachidic alcohol glucoside, cetearyl glucoside, Cocoyl glucoside, the stearate of Natrulon H-10 five, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, spermaceti Base PEG/PPG-10/1 dimethyl silicone polymers 2-3%, lecithin 0.5-1.0%, methyl sesquistearate 0.5- 1.5%th, any one or more combination in PEG-10 dimethyl silicone polymers, hydrolecithin.

4. thickener Carbomer described in claim 1, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, In xanthan gum, starch, biological carbohydrate gum -1, pectin, Scleroglucan, Arabic gum natural gum, hydroxyethyl cellulose any one or Multiple combination.

5. the polyalcohol described in claim 1 is glycerine, propane diols, butanediol, DPG, 1,2- pentanediols, sorbierite, poly- Ethylene glycol -8, in any one or more combination.

6. the plant composition extract described in claim 1 is to be made root of large-flowered skullcap 30-50 parts by the plant of following parts by weight, fly Raise it is careless 20-45 parts, granatum 20-45 parts；Preparation method is as follows：Plant is crushed, is sieved with 20~100 mesh sieve respectively, mixed Close, be 5 by liquid material mass ratio:1~20:1 adds Extraction solvent, after 1~5h of immersion, in the case where 10~100MPa extracts pressure with height Pressure homogeneous extractor carries out normal temperature extraction, after extract solution is centrifuged, is concentrated with film, concentrate macroporous resin adsorption, then Repeatedly eluted with the ethanol that volume fraction is 10~95%, collect eluent, film is concentrated into extract solution and is with the mass ratio of autonomic drug 1:0.1~1:5, butanediol dissolving is added, filtering is obtained plant drug composition；Extraction solvent is that water, ethanol or ethanol are water-soluble Liquid.

7. a kind of preparation method for the skin-moisturizing, skin cream composition without preservative described in claim 1, it is characterised in that Concretely comprise the following steps：

（1）The oil-soluble constitents such as oily matter, oil soluble emulsifying agent, glycerol caprylate, endecatylene acid glyceride are put into Oil cauldron is heated to 80 DEG C, is uniformly mixed, and is completely dissolved it, is oil phase, stand-by；

（2）By water, water soluble emulsifier, polyalcohol, thickener, Sodium Hyaluronate, glucan, allantoin, EDETATE SODIUM, lactic acid Deng water-soluble component put into emulsification pot be heated to 85 DEG C, be uniformly mixed, be completely dissolved it, be water phase, it is stand-by；

（3）, in 1000-8000r/min, mixing speed is in 200-500r/min for control homogeneous speed.Quick put into oil phase emulsifies Pot, homogeneous 3-10min；

（4）Stop homogeneous, maintain the temperature at 80 DEG C, control mixing speed stirs 10min in 200-500r/min；

（5）Speed is kept stirring in 200-500r/min, cooling；

（6）Cool to 40 DEG C and plant composition extract, essence are added into emulsification pot, vacuumize, stir；

（7）Stir, cool to 35 DEG C of dischargings, it is filling to seal up for safekeeping.