CN106722206A - A kind of composition for alleviating alimentary canal malaise symptoms and/or emotional stress and products thereof - Google Patents
A kind of composition for alleviating alimentary canal malaise symptoms and/or emotional stress and products thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/147—Helveticus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/515—Animalis
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/533—Longum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The present invention relates to technical field of health care food, more particularly to a kind of composition for alleviating alimentary canal malaise symptoms and/or emotional stress and products thereof.Said composition is made up of Zymosis soybean meal, probiotics and dusty yeast.The present composition has the significant effect for alleviating alimentary canal malaise symptoms and/or emotional stress, and effect is better than the effect of each single dose；Composition of the invention effectively by adjusting the function normalization of intestines and stomach can reach the purpose for alleviating emotional stress.After present invention addition prebiotics and Fructus Monordicae extract, can further strengthen the effect for alleviating alimentary canal malaise symptoms and/or emotional stress of the present composition.After further addition sweetener of the invention, essence and fruit powder, mouthfeel can be effectively improved.
Description
Technical field
It is more particularly to a kind of to alleviate alimentary canal malaise symptoms and/or mood pressure the present invention relates to technical field of health care food
Composition of power and products thereof.
Background technology
With the derivation transition of the fast-developing and social environment of China's economy, and allegro Modern Live, I
The accounting of state's sub-health population increasingly rises；From the point of view of the statistics of Chinese Medical Association, China's inferior health population accounts for national people
The 70% of mouth, wherein mood inferior health accounting are 25%~28%, and the highbrow incidence of disease being engaged in mental work is compared with body
The old labourer of power will height.
Mood inferior health refers to the abnormal feeling of all, it is indicated that existing nervous, excited, irritable, anxiety, or suppression
Strongly fragrant, terrified uneasy, susceptible to sorrow cry well etc. be main performance symptom.According to World Health Organization's conservative estimation, abnormal feeling is primary symptom
Inferior health in crowd illness rate be 3%~5%.Calculate accordingly, China's abnormal feeling is the existing patient of the inferior health of primary symptom
Number is up within 3600~60,000,000.By 2010, in the middle of the disease that the whole world ranks first 15, it was mental illness to have 5 kinds,
Wherein abnormal feeling is come first of this five kinds of mental illnesses for the inferior health of primary symptom.
Stomach is generally acknowledged mood organ, and the low of mood can influence personal appetite with surging；When human body is chronically at
In the state of tension pressure, while adrenaline secretion, hydrochloric acid in gastric juice can also secrete increase, and hydrochloric acid in gastric juice is to enter under normal circumstances
Can just be secreted during food, the irregular secretion of long-term hydrochloric acid in gastric juice can cause the contraction of stomach parietal vessel scrambling, it is stomach further to deteriorate
Canker.
The change of emotional state can influence the secretion of the blood perfusion and stomach glands of stomach lining, be handed over during exciting and confrontation mood
Sense nerve can produce excitement, and stomach lining vessel retraction, stomach glands secretion is reduced, of flaccid muscles, and obstacle occurs in gastric emptying, occur anti-
The symptoms of digestive tract such as acid, Nausea and vomiting, on the contrary caused parasympathetic nerve excitement is lost, and gastric acid secretion increase can aggravate hydrochloric acid in gastric juice
Secretion increases the infringement aggravated to stomach lining, stomachache and the heartburn symptom of stomach occurs.
Intestinal movement is regulated and controled jointly by enteric nervous system, ganglion prevertebral and nervous centralis, is influenced each other between them, this
One regulated and control network is referred to as brain-gut axis, and wherein enteric nervous system is by the sensory neuron of intestines and stomach, intrerneuron and effector nerve
Unit's composition, effector neuron includes god under the Myenteric plexus of control intestinal movement and regulating intestinal canal secretion, the mucous membrane of blood flow
Through clump.After intestinal bacilli illness, intestine immunity cell or inflammatory cell can stimulate enteric nervous unit release neurotransmitters, and release promotees
The scorching factor, so as to improve the excitability of neuron and influence the conduction of neuron；Pathogenic bacteria also can influence intestines by above-mentioned approach
The water in road, electrolyte balance and enteron aisle sensitiveness, cause the IBS symptoms such as diarrhoea, abdominal discomfort.Corticotropin discharges
Hormone (CRF) and 5-HT are two kinds of important bioactivators during brain-gut axis interacts, and 5-HT can be by Nervous system
The motion and secretion of system influence enteron aisle, while again can be as the signal of interest of central nervous system, control and tune in mood
Section aspect is played an important role.
The supreme officer of stomach is brain centres, and mood is the reaction of nervous centralis, there is close between stomach and mood
Relation, the normalization of functions of intestines and stomach is the important way for alleviating and improving emotional stress.
At present, the regulation ameliorative way for emotional health is broadly divided into non-drug therapy and the major class of medicinal treatment two, its
Middle non-drug therapy is mainly by modes such as psychological regulation, sunlight intervention, food and motions to adjust, non-drug class therapy
Mechanism of action it is indefinite, simultaneously operable property and curative effect aspect it is poor.Medicinal treatment is broadly divided into two kinds of Western medicine and Chinese medicine
Mode, Western medicine is mainly Statins, stable etc., and Western medicine class medicine is effective, but side effect is big, and long-term taking can damage liver
Dirty, kidney and haemocyte, to complication to no effect.From for traditional Chinese medical science angle, abnormal feeling for primary symptom inferior health belong to strongly fragrant disease,
Lily etc., the traditional Chinese medical science has detailed medicine typing to mood inferior health, is broadly divided into stagnation of liver qi, qi depression transforming into fire, blood stasis, phlegm
Obstruction of the circulation of vital energy knot, the mind are deluded and confused, the heart-yin virtual loss, deficiency and exhaustion of liver-YIN, the insufficiency of heart and spleen etc., and corresponding have a different prescriptions, but in
Drug effect fruit is slow, acts on unobvious.
The content of the invention
In view of this, the invention provides a kind of composition for alleviating alimentary canal malaise symptoms and/or emotional stress and its
Product.Said composition and product have the significant effect for alleviating alimentary canal malaise symptoms and/or emotional stress, and effect is better than respectively
The effect of single dose.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides a kind of composition, it is made up of Zymosis soybean meal, probiotics and dusty yeast.
The nutritive value of soybean is very high, containing 40% protein, 20% organic phosphoric acid, vitamin and mineral matter etc., and
And also containing many compositions with bioactivity in soybean, the isoflavone like substance that such as it contains has very much to the health of people
Benefit.During soybean has invigorating the spleen wide, the water that disappears, clearing heat and detoxicating, QI invigorating effect are moisturized；Cure mainly infantile malnutrition due to digestive disturbances or intestinalparasites rush down dysentery, abdominal distension it is thin it is thin, pregnant in
Poison, sore and toxic, traumatism and bleeding etc..Soya bean can also anti-inflammation, it is effective to pharyngitis, conjunctivitis, stomatitis, bacillary dysentery, enteritis.Greatly
During beans have strengthening the spleen and replenishing qi wide, moisturize the water that disappears etc. effect, can be used for deficiency-weakness of spleen-QI, indigestion, infantile malnutrition due to digestive disturbances or intestinalparasites rush down dysentery, abdominal distension win it is thin,
The diseases such as gestosis, sore and toxic, traumatism and bleeding.Calcium, the phosphorus contained in soybean, are susceptible to suffer to prevention Rickets, the elderly
Osteoporosis and neurasthenia and physically weak person are very suitable.Contained iron in soybean, not only amount is more, and is easily absorbed by the body,
Child and hypoferric anemia patient to growing is very helpful.The high density fat being rich in soybean, contributes to
Fall human body with unnecessary cholesterol, therefore, it is often edible to prevent heart disease, coronary sclerosis.Contained dyestuff in soybean
Wood because (isoflavones) can suppress it is a kind of stimulation tumour growth enzyme, prevention tumour growth, anti-curing cancers, especially breast cancer,
Prostate cancer, colon cancer.Contained phytoestrogen in soybean, can adjust the hormonal readiness in climacteric women body, prevent
The loss of calcium in bone, can be with relieving menopausal syndrome, osteoporosis.Contain 85%-90% phosphatidyls in soybean lecithin
Choline and phosphatidyl-ethanolamine, phosphatide glucoside etc., there is good health care effect to human organ.Nearest achievement in research table
It is bright, a large amount of phosphatide are contained in each histoorgan of human body, soybean lecithin can increase tissue function, reduce cholesterol, improve lipid
Metabolism, prevention and treatment cerebral artery, coronary sclerosis, it additionally aids liver health, has certain to hepatitis, fatty liver
Curative effect.In addition, soybean lecithin can also promote the absorption of liposoluble vitamin, constitution and each histoorgan is prevented to be acidified.Though soybean
Rich in nutrition content, but without treatment, many nutritional ingredients are difficult to digest, absorb and utilize.Soybean is fermented, energy
Macromolecular in soybean is resolved into small molecule and some insoluble compounds are resolved into soluble low molecular compound, and by
In the autolysis of microorganism generate soybean it is original without nutritional ingredient, substantially increase the nutritive value of product.
Probiotics is the class active microorganism beneficial to host, is colonized in human body intestinal canal, reproductive system, can be produced
Definite health efficacy is so as to the active beneficial microorganism general name for improving host's microecological balance, playing beneficial effect.It is human body, dynamic
Beneficial bacterium or fungi mainly have in object：Clostridium butyricum, lactobacillus, Bifidobacterium, actinomyces, saccharomycete etc..Current generation
The most powerful product of function studied in boundary be mainly all kinds of microorganism groups of the above into composite reactive probiotics, its extensive use
In bioengineering, industrial or agricultural, food security and life and health field.Patient often takes the health food containing probiotics, can
Prevention and treatment diarrheal disease.
Dusty yeast is that yeast obtained decomposition by the product made by decomposition, but nutriment in dusty yeast,
Therefore the microorganism in dusty yeast absorbs speed and in hgher efficiency, is worth bigger to human nutrition.The effect of dusty yeast
It is mainly extra-nutrition with effect, promotees digestion, promotion embryo growth and development, enhancing immune function of human body, supplement protein, supplement
The each side such as amino acid, and dusty yeast also includes the materials such as vitamin, auxin, various trace elements, is kind of a nutriture value
Value natural flavouring very high.
After the present invention uses cooperatively Zymosis soybean meal, probiotics, dusty yeast, alleviating alimentary canal malaise symptoms and mood
Pressure aspect has significant improvement result, and effect is better than the effect that each component is used alone.
Preferably, in parts by weight, each component consumption is in composition：17~30 parts of Zymosis soybean meal, probiotics 1~
5 parts, 5~10 parts of dusty yeast.
In the embodiment that the present invention is provided, in parts by weight, each component consumption is in composition：Zymosis soybean meal 25
Part, 3 parts of probiotics, 7.5 parts of dusty yeast.
In another embodiment that the present invention is provided, in parts by weight, each component consumption is in composition：Zymosis soybean meal
17 parts, 5 parts of probiotics, 5 parts of dusty yeast.
In another embodiment that the present invention is provided, in parts by weight, each component consumption is in composition：Zymosis soybean meal
30 parts, 1 part of probiotics, 10 parts of dusty yeast.
Preferably, probiotics is selected from bifidobacterium longum, animal bifidobacteria, Lactobacillus helveticus or Lactobacillus rhamnosus.
In the embodiment that the present invention is provided, bifidobacterium longum is bifidobacterium longum Rosell-175.
In the embodiment that the present invention is provided, animal bifidobacteria is animal bifidobacteria
In the embodiment that the present invention is provided, Lactobacillus helveticus is Lactobacillus helveticus Rosell-52.
In the embodiment that the present invention is provided, Lactobacillus rhamnosus is Lactobacillus rhamnosus Rosell-11.
Preferably, the viable bacteria concentration of the raw material bacterium powder of probiotics is not less than 1010cfu/g。
Preferably, probiotics is the mixture of Lactobacillus helveticus and bifidobacterium longum.
In the embodiment that the present invention is provided, probiotics is Lactobacillus helveticus Rosell-52 and bifidobacterium longum Rosell-
175 mixture.
Preferably, Lactobacillus helveticus is (1~3) with the mass ratio of bifidobacterium longum：(1~3).
In the embodiment that the present invention is provided, Lactobacillus helveticus is 1 with the mass ratio of bifidobacterium longum：2.
In another embodiment that the present invention is provided, Lactobacillus helveticus is 2 with the mass ratio of bifidobacterium longum：3.
In another embodiment that the present invention is provided, Lactobacillus helveticus is 1 with the mass ratio of bifidobacterium longum：1.
The health food of alleviation alimentary canal malaise symptoms and/or emotional stress is being prepared present invention also offers said composition
Or the application in medicine.
In the embodiment that the present invention is provided, alimentary canal malaise symptoms include dry, dysphagia, appetite disappear, nausea
Vomiting, ventosity, stomachache sour regurgitation, stomachache, rectal pain, constipation or suffer from diarrhoea in one or more.
In the embodiment that the present invention is provided, emotional stress include one kind in somatic anxiety, depressed or indignation-hostility or
It is several.
Present invention also offers a kind of health food, including composition of the invention.Said composition is by Zymosis soybean meal, benefit
Raw bacterium and dusty yeast are constituted.
Preferably, health food also includes prebiotics and/or Fructus Monordicae extract；In parts by weight, in health food
Each component consumption is：17~30 parts of Zymosis soybean meal, 1~5 part of probiotics, 5~10 parts of dusty yeast, 5~8 parts of prebiotics, arhat
1~3.5 part of berry extract.
Preferably, health food also includes prebiotics, sugar alcohol, Fructus Monordicae extract, essence and fruit powder；With weight portion
Meter, each component consumption is in health food：17~30 parts of Zymosis soybean meal, 1~5 part of probiotics, 5~10 parts of dusty yeast is prebiotic
5~8 parts of unit, 30~50 parts of sugar alcohol, 1~3.5 part of Fructus Monordicae extract, 1~3 part of essence, 5~10 parts of fruit powder.
The present invention is with Zymosis soybean meal, probiotics, prebiotics, dusty yeast, sugar alcohol, the mutually coordinated work of Fructus Monordicae extract
With probiotics is balanced by nursing one's health gut flora, and emotional stress is alleviated through the path of brain intestines axle；Zymosis soybean meal is quick
Alleviate stomachache, the heartburn acute disease of stomach at the same time it can also suppress the effect of helicobacter pylori, protect stomach lining, reach adjustment stomach
Gut function, safeguards gastrointestinal health；The dusty yeast rich in B family vitamin can play certain work of releiving to emotional stress simultaneously
With.Prebiotics is not digested and assimilated by enteron aisle in itself, can be fermented by enteron aisle, stimulates the growth of gut flora, while prebiotics
Also the wriggling of enteron aisle can be promoted, improves constipation；The sugariness of sugar alcohol is respectively less than sucrose, containing relatively low heat, while having heat absorption
Effect, provide sugariness improve mouthfeel while can produce refrigerant sense；Fructus Monordicae extract taste is extremely sweet, the super sucrose of its sugariness
240 times of sugariness, sweet taste has the rear sweet taste similar to Radix Glycyrrhizae close to granulated sugar, can suppress the displeased of bitter taste after some raw materials
Happy sense.
Preferably, prebiotics is selected from inulin, FOS, resistant dextrin, xylo-oligosaccharide, stachyose or galactooligosaccharide
One or more.
In the embodiment that the present invention is provided, prebiotics is galactooligosaccharide.
Preferably, sugar alcohol is selected from xylitol, D-sorbite, mannitol, antierythrite or isomalt
One or more.
In the embodiment that the present invention is provided, sugar alcohol is xylitol.
In the embodiment that the present invention is provided, essence is orange flavor.But the essence species of those skilled in the art's accreditation
Within the scope of the present invention, the present invention is not limited herein.
In the embodiment that the present invention is provided, fruit powder is sweet orange powder.But the fruit powder species of those skilled in the art's accreditation is equal
Within the scope of the present invention, the present invention is not limited herein.
Preferably, the formulation of health food of the present invention is tablet, pulvis, liquid preparation or capsule.But this area skill
Art personnel think feasible formulation within protection scope of the present invention, and the present invention is not limited herein.
Present invention also offers a kind of medicine, including composition of the invention.Said composition is by Zymosis soybean meal, probiotics
Constituted with dusty yeast.
Preferably, the formulation of medicine of the present invention is tablet, pulvis, liquid preparation or capsule.But people in the art
Member thinks feasible formulation within protection scope of the present invention, of the invention not limit herein.
In the present invention, medicine of the present invention also includes pharmaceutically acceptable auxiliary material.
The invention provides a kind of composition for alleviating alimentary canal malaise symptoms and/or emotional stress and products thereof.The group
Compound is made up of Zymosis soybean meal, probiotics and dusty yeast.The present invention has one of following advantage：
1st, said composition has the significant effect for alleviating alimentary canal malaise symptoms and/or emotional stress, and effect is better than respectively
The effect of single dose；Composition of the invention effectively by adjusting the function normalization of intestines and stomach can reach alleviation mood pressure
The purpose of power.
2nd, after the present invention adds prebiotics and Fructus Monordicae extract, the alleviation digestion of the present composition can further be strengthened
The effect of road malaise symptoms and/or emotional stress.
3rd, after the present invention further adds sweetener, essence and fruit powder, mouthfeel can be effectively improved.
Brief description of the drawings
Fig. 1 shows that the pulvis of the embodiment of the present invention 4 alleviates gastrointestinal symptoms crowd's experimental result；
Fig. 2 shows that the capsule of the embodiment of the present invention 5 alleviates gastrointestinal symptoms crowd's experimental result.
Specific embodiment
The invention discloses a kind of composition for alleviating alimentary canal malaise symptoms and/or emotional stress and products thereof, ability
Field technique personnel can use for reference present disclosure, be suitably modified technological parameter realization.In particular, it is all similar to replace
Change and change apparent to those skilled in the art, they are considered as being included in the present invention.Side of the invention
Method and application have been described by preferred embodiment, related personnel substantially can not depart from present invention, spirit and
In the range of method described herein and application are modified or suitably change is realized and apply the technology of the present invention with combining.
Following examples of the present invention are that to use non-transgenic pure natural soybean be by fermentation raw material, and being equipped with to be adjusted
The probiotics strain of emotional health and the dusty yeast rich in B family vitamin, adjust functions of intestines and stomach normalization, by the road of brain intestines axle
Emotional stress is alleviated in footpath.Delayed by adjusting stomachache caused by Gastroesophageal reflux disease, heartburn and gut flora the balance of stomach
The associated emotional stress symptom of solution.
In the embodiment that the present invention is provided, Zymosis soybean meal isZymosis soybean meal.
It is raw materials used in composition for alleviating alimentary canal malaise symptoms and/or emotional stress that the present invention is provided and products thereof
Or auxiliary material can be bought by market.
With reference to embodiment, the present invention is expanded on further：
The preparation of the composition of embodiment 1
The present embodiment composition is mixed by the component of following weight portion：
The preparation of the composition of embodiment 2
The present embodiment composition is mixed by the component of following weight portion：
The preparation of the composition of embodiment 3
The present embodiment composition is mixed by the component of following weight portion：
The efficacy test of the composition of test example 1
The composition that embodiment 1-3 is made carries out alleviating gastrointestinal symptoms efficacy test, while withHair
Ferment soy meal, probiotics A (Lactobacillus helveticus Rosell 52：Bifidobacterium longum Rosell 175=1:2), probiotics B (Switzerland
Lactobacillus Rosell 52：Bifidobacterium longum Rosell 175=2:3), probiotics C (Lactobacillus helveticus Rosell 52：Bifid long
Bacillus Rosell 175=1:1), this several single dose of dusty yeast are used as control.
Test method：Have 160 healthy volunteers (38 ± 11 years old)：Male 58 (36%), women 102 (64%).
All patients, are randomly divided into 8 groups, and every group of 20 people carry out double blind experiment, and experimental group and control group are implemented with tuxedo with 3g daily
The composition and each single dose of example 1-3.At the end of research, the experiment that 152 participants complete (5% exits from research).8
Volunteer (5 men, 3 female) excludes due to not abiding by the agreement.Finally, 152 results of healthy volunteer are retained and do PP analyses
(per-protocol analysis), more than 3 weeks, whole experimental result evaluation used visual simulation scale to duration of experiment
Chi scores (VGA, MAX=10) to be evaluated.Result of the test is as follows：
The each group sample of table 1 alleviates gastrointestinal symptoms efficacy test appraisal result
Note：* example 1 is represented with one-component comparing difference significantly, a represents example 2 with one-component comparing difference significantly,
A represents that example 3 is notable with one-component comparing difference.
Result of the test shows that effect of embodiment 1-3 compositions is considerably better than each control group, shows fermentation soybean
The effect that powder, probiotics and dusty yeast are used cooperatively is more preferable.
Embodiment 4：The preparation of pulvis
It (is as follows a unit packaging with 5g pulvis, following component is by weight that the present embodiment composite formula composition is
Meter)：
Embodiment 5：The preparation of capsule
The present embodiment composite formula composition (is as follows a unit packaging with 500mg capsules, following component is by weight
Meter)：
Embodiment 6：The preparation of tablet
The present embodiment composite formula composition is as follows：
Experimental example 2 alleviates gastrointestinal symptoms crowd experiment
Have 75 healthy volunteers (38 ± 11 years old)：Male 21 (28%), women 54 (72%).All patient (n=
75), random packet, carries out double blind experiment, and experimental group daily with the tuxedo composition of 1 bag embodiment 4, take by placebo
Starch is substituted.At the end of research, the experiment that 72 participants complete (4% exits from research).8 students (3 men, 5 female)
Excluded due to not abiding by the agreement.Finally, 64 knots of healthy volunteer's (probiotic group and placebo are respectively 31 and 33)
Fruit be retained is PP analysis (per-protocol analysis), duration of experiment more than 3 weeks, whole experimental result evaluation
Evaluated using visual analogue scale scoring (VGA, MAX=10).
Take the effect of the symptom of digestive tract that probiotics causes to everyday stress：Taking the composition of embodiment 4 can reduce by 2 classes
The gastrointestinal symptom of stress-induced, i.e. stomachache and nausea/vomiting.Stomachache significantly improves (- 2.59VS-0.34 placebos；Fig. 1) and
Nausea/vomiting (the placebos of -0.82VS 0.77；Fig. 1).Flatulence and exhaust are also reduced (- 3.25VS in probiotic supplemented group
1.7 placebos；Fig. 1).
Experimental example 3 alleviates people's stress crowd experiment
55 health volunteers are grouped at random, double blind experiment is carried out, experimental group takes 2 implementations with any one meal daily
The composition of example 5, placebo is taken 2 starch capsules and is substituted, and experiment proves that (Fig. 2) oral composition of embodiment 5 shows
There is wholesome effect with depressed relevant behavior for anxiety, the level of UFC (UFC) is not than before taking yet
Low 50 mcg/ml.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of composition, it is characterised in that be made up of Zymosis soybean meal, probiotics and dusty yeast.
2. composition according to claim 1, it is characterised in that in parts by weight, each component consumption in the composition
For：17~30 parts of Zymosis soybean meal, 1~5 part of probiotics, 5~10 parts of dusty yeast.
3. composition according to claim 1, it is characterised in that the probiotics is selected from bifidobacterium longum, animal bifid
Bacillus, Lactobacillus helveticus or Lactobacillus rhamnosus.
4. composition as claimed any one in claims 1 to 3 is preparing alleviation alimentary canal malaise symptoms and/or emotional stress
Health food or medicine in application.
5. application according to claim 4, it is characterised in that the alimentary canal malaise symptoms include dry, dysphagia,
Appetite regression, n and V, ventosity, stomachache sour regurgitation, stomachache, rectal pain, constipation or suffer from diarrhoea in one or more.
6. application according to claim 4, it is characterised in that the emotional stress include somatic anxiety, depressed or indignation-
One or more in hostility.
7. a kind of health food, it is characterised in that including composition as claimed any one in claims 1 to 3.
8. health food according to claim 7, it is characterised in that the health food also includes prebiotics and/or sieve
Chinese berry extract；In parts by weight, each component consumption is in the health food：17~30 parts of Zymosis soybean meal, probiotics 1~
5 parts, 5~10 parts of dusty yeast, 5~8 parts of prebiotics, 1~3.5 part of Fructus Monordicae extract.
9. health food according to claim 8, it is characterised in that the prebiotics is selected from inulin, FOS, resistance
One or more of dextrin, xylo-oligosaccharide, stachyose or galactooligosaccharide.
10. a kind of medicine, it is characterised in that including composition as claimed any one in claims 1 to 3.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107996936A (en) * | 2017-12-15 | 2018-05-08 | 徐州统食品工业有限公司 | A kind of solid beverage for improving stomach health problem |
| CN108065398A (en) * | 2017-12-14 | 2018-05-25 | 广州普维君健药业有限公司 | Infant's probiotic oral composition and its preparation method and application |
| CN108077935A (en) * | 2018-01-22 | 2018-05-29 | 广东格物生物科技有限公司 | Nurse one's health middle-aged and elderly people's function of intestinal canal microbial inoculum and its preparation method and application |
| CN108079023A (en) * | 2018-01-04 | 2018-05-29 | 诺佰克（武汉）生物科技有限公司 | Application of Lactobacillus equine ZW3 in the preparation of drugs and food for preventing or improving stress-induced mental problems |
| CN108186661A (en) * | 2017-12-15 | 2018-06-22 | 哈尔滨珍宝制药有限公司 | A kind of pharmaceutical composition comprising Clindamycin Hydrochloride and preparation method thereof |
| CN108669563A (en) * | 2018-03-30 | 2018-10-19 | 北京斯利安药业有限公司 | A kind of composition, its application and strengthen immunity, the product for improving allergy |
| CN109771470A (en) * | 2019-03-21 | 2019-05-21 | 慕恩（广州）生物科技有限公司 | A kind of composition containing probiotics and preparation method thereof |
| CN109924507A (en) * | 2019-03-04 | 2019-06-25 | 山东环亿生物科技有限公司 | A kind of probiotic composition and preparation method thereof improving mood |
| CN111685328A (en) * | 2019-07-23 | 2020-09-22 | 河北一然生物科技有限公司 | Naqu 4580 probiotics and application of preparation thereof in food for regulating emotion |
| CN113040385A (en) * | 2021-02-26 | 2021-06-29 | 东莞自然衡健康科技有限公司 | Composition for relieving emotion and maintaining beauty and keeping young and preparation method thereof |
| CN113583923A (en) * | 2021-09-28 | 2021-11-02 | 中国农业大学 | Probiotic composition and application thereof in preparation of medicine for treating constipation and depression |
| CN116790448A (en) * | 2023-08-21 | 2023-09-22 | 新益(天津)生物科技有限责任公司 | Lactobacillus helveticus OPB102 capable of relieving constipation and diarrhea and application thereof |
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| CN107996936A (en) * | 2017-12-15 | 2018-05-08 | 徐州统食品工业有限公司 | A kind of solid beverage for improving stomach health problem |
| CN108079023A (en) * | 2018-01-04 | 2018-05-29 | 诺佰克（武汉）生物科技有限公司 | Application of Lactobacillus equine ZW3 in the preparation of drugs and food for preventing or improving stress-induced mental problems |
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| CN109924507B (en) * | 2019-03-04 | 2021-06-11 | 山东环亿生物科技有限公司 | Probiotics composition for conditioning emotion and preparation method thereof |
| CN109924507A (en) * | 2019-03-04 | 2019-06-25 | 山东环亿生物科技有限公司 | A kind of probiotic composition and preparation method thereof improving mood |
| CN109771470A (en) * | 2019-03-21 | 2019-05-21 | 慕恩（广州）生物科技有限公司 | A kind of composition containing probiotics and preparation method thereof |
| CN111685328A (en) * | 2019-07-23 | 2020-09-22 | 河北一然生物科技有限公司 | Naqu 4580 probiotics and application of preparation thereof in food for regulating emotion |
| CN111685328B (en) * | 2019-07-23 | 2022-10-21 | 河北一然生物科技股份有限公司 | Naqu 4580 and application of Naqu 4580 preparation in food for regulating emotion |
| CN113040385A (en) * | 2021-02-26 | 2021-06-29 | 东莞自然衡健康科技有限公司 | Composition for relieving emotion and maintaining beauty and keeping young and preparation method thereof |
| CN113583923A (en) * | 2021-09-28 | 2021-11-02 | 中国农业大学 | Probiotic composition and application thereof in preparation of medicine for treating constipation and depression |
| CN113583923B (en) * | 2021-09-28 | 2021-12-07 | 中国农业大学 | Probiotic composition and application thereof in preparation of medicine for treating constipation and depression |
| CN116850213A (en) * | 2023-07-24 | 2023-10-10 | 青岛东海药业有限公司 | Probiotic composition for improving maternal and offspring autism depression behavior and application thereof |
| CN116850213B (en) * | 2023-07-24 | 2024-04-30 | 青岛东海药业有限公司 | Probiotic composition and application thereof |
| CN116790448A (en) * | 2023-08-21 | 2023-09-22 | 新益(天津)生物科技有限责任公司 | Lactobacillus helveticus OPB102 capable of relieving constipation and diarrhea and application thereof |
| CN116790448B (en) * | 2023-08-21 | 2024-01-12 | 新益(天津)生物科技有限责任公司 | Lactobacillus helveticus OPB102 capable of relieving constipation and diarrhea and application thereof |
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Application publication date: 20170531 |