CN104839683A - Constipation medical formula food - Google Patents

Abstract

The invention belongs to the technical field of medicinal and edible formulas and new resource foods, and particularly provides a medical formula food, a specific medical formula food or a non-specific medical formula food for a patient with constipation; the formula is prepared by reasonably mixing a plurality of traditional Chinese medicines with homology of medicine and food according to the requirements of special medical purpose formula food general rules, reasonably combining the physical characteristics of constipation patients according to the essence theory of the traditional Chinese medicine, extracting essence of traditional Chinese medicine extract with dual purposes of medicine and food, a plurality of micro-encapsulated probiotics and short peptides, prebiotics, amino acids, carbohydrates, grease with health care function, a plurality of vitamins and mineral substances extracted by biological enzymolysis through a plurality of prehydrolysis SBE technologies, mixing the short peptides, the prebiotics, the amino acids, the carbohydrates, the grease with health care function, the vitamins and the mineral substances, and the like, not only can be used as a single nutrient source to meet the nutritional requirements of the constipation patients, but also has the effects of relaxing bowel, nourishing yin, moistening dryness, nourishing liver and kidney, clearing.

Description

Constipation medical formula food

technical field

The invention belongs to the technical field of medicine and food homologous formula and new resource food, and specifically combines the traditional Chinese medicine essence theory of "medicine and food homologous Chinese medicine" with "multiple probiotics", and adds short peptides, prebiotics, Constipation medical formula food, specific medical formula food or non-medical formula food made of amino acid, carbohydrate, oil with health function, multivitamin and multi mineral.

Background technique

Constipation is one of the more common modern sub-health states. It mostly occurs in people with gastrointestinal dysfunction such as mental workers and students who sit at their desks for a long time. Traditional Chinese medicine believes that constipation is the result of dysfunction of the large intestine, mainly in the following aspects. (1) Deficiency of the spleen, which is the most common pathogenesis of constipation. If the spleen is deficient in transportation and transformation, the functions of ascending and descending will be out of balance, manifested as constipation accompanied by symptoms of spleen deficiency. , Inability to defecate, almost no pain without defecation for many days, this type is more common, mostly caused by unsuitable diet, sedentary and lack of exercise and other bad living habits , although the large intestine is mainly responsible for pushing out the old and bringing forth the new and conducting the dross, its qi is dominated by the descending effect of the stomach qi. The stomach, large and small intestines are actually integrated. The Stomach Meridian of Foot Yangming runs on the front side of the human body and runs through the upper, lower, inner and outer parts. It is dominated by the human atmosphere. Stomach qi descends for smoothness, and descends for nourishment. If its descending effect is out of balance, the stomach meridian excess heat syndrome will appear, manifested as constipation, dry and hot anus, bad breath, dry mouth, red tongue, rapid pulse, etc. (3 ) Constipation due to kidney deficiency, the kidney is in charge of the two stools, the front and back Yin are dominated by the kidney, and the kidney is the gate of the stomach. Under physiological conditions, the nourishment of the kidney essence is the basis for the large intestine to keep the essence moist. The power of dispersing, so Xin can moisten dryness, and the normal gasification of kidney essence and yin and yang vitality in the lower Jiao ensures the normal stool. Those who belong to kidney deficiency, (4) Lung qi is stagnated, the lung and the large intestine are on the outside and inside, the lung qi governs the circulation and rapid decline, and the viscera becomes yin, and the large intestine governs the excretion of dross, and the viscera becomes yang. Yin ascends and yang descends. If the external evils are bound to the surface, the lung qi will not be ventilated, and the internal qi will not be able to flow down, resulting in temporary constipation with dry stools. "The same source of medicine and food" is one of the most valuable contributions to human beings in the original Chinese medicine. 1. Chinese medicine has always emphasized that "medicine therapy is not as good as diet therapy". Diet therapy has become the best choice for modern people to pursue a return to nature and a healthy diet; it allows people to eliminate pain in the process of enjoying delicious food, and avoids the pain of injections, medicines, and even surgery.

For special nutritional food, there are corresponding regulations and development and application in developed countries such as the United States and the European Union; while my country's GB29922-2013 "General Rules for Formula Foods for Special Medical Purposes" national food safety standard Chinese medicine food clearly stipulates: 2.1.1 Medical formula food : Formula food for special medical purpose that can be used as a single source of nutrition to meet the nutritional needs of the target population; 2.1.2 Formula food for specific medicine: formula food for special medical purpose that can be used as a single source of nutrition to meet the nutritional needs of the target population under specific diseases or medical conditions;

Traditional Chinese medicine believes that: "The spleen (i.e. the digestive system) is the foundation of the day after tomorrow", gastrointestinal health is the foundation of health, 99% of human nutrition needs to be absorbed by the intestines, and intestinal diseases are also the source of all diseases; , the proportion of beneficial bacteria (probiotics) in the intestinal tract gradually decreases; for example, bifidobacteria account for 98% in infants and young children, drop to 10% in middle age, and only 5% after the age of 65; the older the person, the more probiotics less, the intestinal function will gradually decline. More and more studies have shown that the normal flora plays many irreplaceable roles in human digestion, immunity and disease resistance; changes in the composition of intestinal flora are associated with various diseases , especially the occurrence and development of intestinal diseases are closely related, and it has been found from existing clinical studies that probiotics can regulate intestinal flora and control intestinal inflammation, which is a safe and effective intervention regulation method;

The relationship between constipation and intestinal flora: Constipation is a disease. According to the survey, constipation is a fairly common disease. A considerable proportion of men and women have experienced constipation. There are many factors that cause constipation. Among them, intestinal flora It is a very important factor. A healthy intestinal tract is inseparable from the beneficial intestinal flora inside. Under healthy conditions, the beneficial bacteria in the intestinal flora are dominant, and its representatives such as Bifidobacterium and Lactobacillus wait. For example, bifidobacteria, which play an important role in maintaining normal intestinal peristalsis, because bifidobacteria and other obligate anaerobic bacteria have the function of acid production, it can make the intestinal lumen an acidic environment, and has the function of regulating intestinal The role of normal intestinal peristalsis and maintaining physiological functions. If the intestinal bifidobacteria are lacking, the intestinal peristaltic function will be reduced, and the feces in the intestinal cavity will not be easily excreted from the body, causing constipation. Long-term constipation will cause a large amount of harmful substances in the feces. Repeated stimulation of the intestinal wall may cause rectal cancer. Normal feces contain 70-80% water. It is very necessary for beneficial bacteria to dominate, so long-term habitual constipation is not a normal manifestation and should be given attention;

At present, there are food-derived short peptides on the market as the main raw material, adding extracts of shiitake mushrooms, tangerine peel, wolfberry, yam, poria cocos, sealwort, etc., multivitamins and minerals to form a compound formula, and there are also probiotics bacteria as the main raw material, but it has not been found to combine the physical characteristics of patients with constipation. According to the essence theory of traditional Chinese medicine, it varies from person to person. Short peptides as the main raw material, medical formula food, specific medical formula food or similar products made of prebiotics, carbohydrates, oils with health functions, amino acids, multivitamins, and multi minerals as auxiliary materials.

purpose of invention

The purpose of the present invention is to creatively combine a variety of probiotics that can improve human immunity with the extracts of the compound recipe of "medicine and food homologous Chinese medicine" on the basis of inheriting the essence of traditional Chinese medicine theory of treatment, adding short peptides and amino acids , carbohydrates, fats with health care functions, multivitamins, and multiminerals are used as auxiliary materials, which can not only supplement the necessary nutrients for constipation patients, improve the nutritional status of the body, but also use the functional factors in the dual-purpose Chinese herbal medicine to regulate the body Function, probiotics can regulate intestinal flora, less toxic and side effects, safe and effective, and easy to accept medical formula food, specific medical formula food or non-medical formula food suitable for constipation patients.

Invention content:

According to the requirements of the "General Rules for Formulated Foods for Special Medical Purposes", combined with the physical characteristics of patients with constipation, and comprehensive research results in advanced physiology, medicine, nutrition and clinical application of Harvard University in the United States, the research and development team is based on "replenishing while eliminating", The quintessence theory of traditional Chinese medicine of "balanced care" (the liver, spleen, and kidney are the main principle), using one or several medicinal and edible Chinese medicine extracts and new resource foods, a variety of probiotics, short-term Peptide is the main raw material, with prebiotics, carbohydrates, oils with health functions, amino acids, multi-vitamins and mineral supplementary materials, not only can be used as a single source of nutrition to meet the nutritional needs of patients with constipation, but also laxative, nourishing yin Medical formula food, specific medical formula food or non-medical formula food (combined compound formula) that moisturizes dryness, nourishes liver and kidney, clears heat and eliminates accumulation, guides stagnation and laxative, detoxifies intestines, and prevents and treats constipation;

1, the main component of formula of the present invention is:

Chinese herbal extracts are based on the physical characteristics of patients with constipation, based on the principle of harmonization of the liver, spleen, and kidneys in TCM theory, using functional factors in medicinal and edible Chinese herbal medicines to regulate body functions and enhance resistance, and select the following categories Compatibility of medicines; among them: senna leaf purging heat stagnation, laxative, diuresis, used for stagnation of heat knots, constipation abdominal pain, edema and fullness, dendrobium beneficial stomach and promoting body fluid, nourishing yin and clearing heat, raw rhubarb main function is to attack stagnation and guide Stagnant, purging and laxative, used for stagnation of excess heat in the stomach and intestines, constipation, psyllium seed diuresis, clearing heat, improving eyesight, and eliminating phlegm. Yu Liren has the effects of moistening dryness and smoothing the intestines, promoting stagnation of Qi, promoting water and reducing swelling, perilla descending Qi and eliminating phlegm, relieving cough and asthma, moistening the intestines and laxatives, fat sea clearing heat, moistening lungs, relieving throat, detoxifying, dandelion clearing heat and detoxifying, Diuretic and dispelling stagnation, cassia seed has the effects of clearing liver fire, dispelling rheumatism, nourishing kidney and improving eyesight, moistening intestines and laxative, etc. konjac konjac is cold, pungent, and poisonous; it can promote blood circulation and remove blood stasis, detoxify and reduce swelling, widen intestines and laxative, reduce phlegm and soften firmness ; Lily nourishes yin and moistens the lungs; clears the heart and calms the nerves, Polygonatum nourishes yin, moistens dryness, relieves restlessness, and quenches thirst;

The medicinal and edible Chinese medicine extract of the present invention refers to dendrobium, senna leaf, raw rhubarb, astragalus, plantago seed, cordyceps militaris, hemp seed, Yu Liren, perilla seed, fat sea, dandelion, licorice, cassia seed, Raspberry, lily, polygonatum, aloe vera, orange peel, hawthorn, mulberry, almond, dark plum, seabuckthorn, mangosteen, peach kernel, sealwort, red bean, konjac malt, houttuynia cordata, honeysuckle, spirulina, dietary fiber, yeast, euglena , chia seeds, psyllium husks, eucommia male flowers, and milk mineral salts , one or several of them, extracted by bio-enzyme or pre-hydrolyzed SBE and microencapsulated, spray-dried and freeze-dried extracts after the mixture;

2. A variety of probiotics: Most of the probiotics can reach the intestinal tract through the strong acid environment of the stomach to promote the proliferation of probiotics, adjust the micro-ecological balance in the intestines, promote the absorption of trace elements, enhance the motility function of the spleen and stomach, and accelerate the recovery of drugs. Efficient absorption, improving the balance of microbiota or enzymes on the mucosal surface, or stimulating the body's specific or non-specific immune mechanism, improving the body's colonization resistance or immunity; In rats, it can significantly reduce the level of intestinal-derived endotoxemia and prevent the occurrence of liver damage; selective intestinal decontamination is also an important measure to adjust the intestinal microecology. Some studies have applied the intestinal non-absorbable antibiotic rifaximin (rifaximin), which enhances resistance by inhibiting the growth of urease and ammonia-producing bacteria in the intestine;

Various probiotics described in the present invention all adopt the probiotics after microencapsulation, and its described probiotics are: wherein one, several or all of Bifidobacterium, Lactobacillus, Streptococcus thermophilus, Pediococcus lactis mix;

a The bifidobacterium above refers to: Bifidobacterium adolescentis, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium animal (Bifidobacterium lactis) ;

The Lactobacillus above refers to: Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus , Lactobacillus reuteri, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus crispatus, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus reuteri;

3. Short peptides: oligopeptides, which refer to a class of small molecular proteins that are separated and extracted from animal or vegetable proteins by bio-enzyme engineering technology. The average molecular weight is below 1000 Dalton, easily soluble in water, stable to acid and heat , can be directly absorbed without digestion, has high bioavailability, and is superior to free amino acids and complete proteins in absorption and utilization. It can be used in protein supplement foods, especially for people with low digestion and absorption capabilities. Short peptides are Excellent nitrogen source. In addition to nutritional functions, short peptides also have a series of physiologically active functions: improving digestion and absorption of the small intestine, enhancing immunity, anti-oxidation, assisting in regulating blood sugar, assisting in regulating blood lipids, assisting in lowering blood pressure, and anti-aging. Radiation, to promote mineral absorption, to enhance the effect of functional factors in Chinese herbal medicines;

The short peptide in the present invention refers to one, several or all of corn oligopeptides, wheat oligopeptides, marine collagen peptides, marine bone peptides, soybean protein peptides, whey protein peptides, and ovalbumin peptides;

4. Prebiotics: to promote intestinal colonization of probiotics, intestinal convergence, reduce intestinal pH environment, and not be used by most intestinal spoilage bacteria, but can promote beneficial bacteria in the human body - Lactobacillus, Bifidobacteria growth and reproduction, which can inhibit the growth of spoilage bacteria, and help to improve and maintain the normal function of the intestinal tract; long-term consumption can delay aging, laxative, improve immunity, reduce the burden on the liver, improve the absorption rate of nutrients, especially to improve the body Absorption of calcium, iron, zinc and other metal ions; it can selectively promote the growth and reproduction of beneficial bacteria (bifido, lactic acid), and can also be metabolized into acidic products such as lactic acid and other organic acids, reducing the pH value in the colon and inhibiting The growth of harmful bacteria in the intestinal tract; make the water and electrolyte in the small intestine stay in the intestinal cavity, produce a hypertonic effect, stimulate intestinal peristalsis and cause laxative, thereby promoting the discharge of intestinal toxins and other toxic substances, lactulose can also directly inactivate intestinal Toxins, lower intestinal pH, have been widely used in the treatment of children's resistance;

The prebiotics described in the present invention are of two types

a. Exogenous probiotics have a strong colonization effect. Prebiotics: extracts of yam, Poria cocos, barley, gallinacea, Gorgon, inulin;

b. Ordinary prebiotics: isomaltooligosaccharide, fructooligosaccharide, trehalose, soybean oligosaccharide, xylooligosaccharide, raffinose oligosaccharide, stachyose, yeast;

The prebiotics described in the present invention are: Chinese yam, poria cocos, coix seed, gallinacea, Gorgon fruit, extract of inulin, cottonseed oligosaccharide, stachyose, yeast, isomaltooligosaccharide, trehalose, fructooligosaccharide , soybean oligosaccharides, xylooligosaccharides, one, several or all mixed;

5. Carbohydrates: Carbohydrates are composed of three elements: carbon, hydrogen and oxygen. It is the cheapest nutrient among the three main nutrients that provide heat energy for the human body. When the intake is sufficient, it can be quickly oxidized in the body and provided in time Energy, avoid using precious protein to provide energy, carbohydrates are also important components of glycoproteins in cell membranes, glycolipids in nerve tissues, and deoxyribonucleic acid (DNA) that transmits genetic information, and glycogen contained in carbohydrates, When it is fully stored in the liver, the liver cells have a strong ability to detoxify certain toxic chemicals and toxins produced by various pathogenic microorganisms;

The carbohydrates described in the present invention refer to L-arabinose, fructose, mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast β-glucan, polyfructose, galactose, lactose, glucose, maltose, carbohydrate One, several or all of compounds, fats with health functions, starch, and glycogen are mixed;

6. The oil and ester with health care function means that it has a health care effect on the human body and can increase the energy of the final product, so that the energy contained in every 100g of the final product of the present invention should not be less than 295kJ (70kcal); It can also prevent arteriosclerosis, stroke and heart disease. Fish oil is effective for hypertension, coronary heart disease, stroke, diabetes, rheumatoid arthritis, cancer and other diseases; linseed oil has the effects of losing weight, lowering cholesterol, and improving kidney function; peony seed oil can lower blood fat and blood pressure, and enhance autoimmunity , prevent diabetes and prevent cancer; samara oil has the effect of preventing and treating hypertension, hyperlipidemia, vascular sclerosis and other diseases;

The fats and oils with health care function described in the present invention refer to linseed oil, peony seed oil, samara oil, milk thistle seed oil, phytosterol ester, royal rice oil, tea seed oil, fish oil, fish oil extract, peanut four Alkenic acid oil, sucrose polyester, DHA algae oil, krill oil, Suaeda salsa seed oil, saponica fruit oil, salina fruit oil, medium-chain triglycerides, yellow gelatin, eucalyptus fruit oil, Long handle almond oil, medium and long chain fatty acid edible oil, ingot maple seed oil, epigallocatechin gallate, diglyceride oil, lutein ester, one, several or all mixed;

7. Amino acid: divided into essential amino acid and non-essential amino acid, which is the basic unit of protein, endows protein with specific molecular structure and form, and makes it biochemically active; intake of appropriate amount of methionine is helpful for the metabolism of various sulfur-containing compounds in the human body And the methyl group contained in it can detoxify toxic substances or drugs through methylation; leucine can repair muscles, control blood sugar, and provide energy to body tissues; the essential amino acid phenylalanine can inhibit cancer growth, and can reduce the toxic and side effects of drugs, lysine can improve the absorption and utilization of food protein, achieve balanced nutrition, and promote growth and development; arginine helps to convert ammonia in the blood into urea and excrete it; for high Ammoniaemia, liver dysfunction, etc. are effective; histidine reduces the acidity of gastric juice, relieves the pain of gastrointestinal surgery, relieves vomiting during pregnancy and stomach burning sensation, inhibits digestive tract ulcers caused by autonomic nervous tension, and is effective for allergies Diseases, such as asthma, are also effective; tryptophan can prevent pellagra, depression, improve sleep and regulate mood;

Amino acid in the present invention refers to L-glutamine, γ-aminobutyric acid, pearl peptide powder, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histamine Acid, tryptophan, citrulline, ornithine, taurine, one, several or all mixed;

8. Vitamins and minerals: vitamins and minerals are essential nutrients for the human body, and the vitamins added in the present invention are vitamins and minerals are essential nutrients for the human body;

The vitamins added in the present invention are vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin Be, vitamin Bu, niacin, folic acid, pantothenic acid, One, several or all of choline and biotin are mixed;

The minerals added in the present invention are calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum, one, several or all of them mixed. The mineral is added as an organic or inorganic compound of the mineral;

The amount of added vitamins and minerals in the present invention is implemented with reference to the "General Rules for Formulated Foods for Special Medical Purposes". Now taking 1000g of finished products as an example, the added amounts are 0.01g of vitamin A, 0.000015g of vitamin D, 0.12g of vitamin E, 0.0075g of vitamin K, Vitamin K10.00001g, vitamin C10.625g, vitamin B10.016g, vitamin B20.016g, vitamin B60.015g, vitamin B0.0023g, vitamin Be, vitamin Bu, niacin 0.2g, folic acid 0.003g, pantothenic acid 0.051g, bile Alkali 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, Iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g;

The present invention integrates microcapsules, biological enzymolysis, pre-hydrolysis SBE, spray drying and freeze-drying to form the key technology of industrial production; microencapsulation protection technology effectively solves the problem of high temperature and strong acid gastric juice in the process of oral administration. inactivation; use the three-layer protein deep-buried microcapsule technology, and then mix it with the traditional Chinese medicine extract extracted and microencapsulated by biological enzymatic hydrolysis or pre-hydrolysis SBE technology to solve the problem of "multiple probiotics" and "medicine and food". The problem of coexistence of components of homologous traditional Chinese medicines has a certain resistance to high temperature and strong acid properties, which is conducive to the smooth passage of probiotics through gastric juice to the intestinal tract through oral administration, so that the efficacy of the product in preventing and treating constipation is greatly improved compared with similar products in the market;

9. Use the above-mentioned integrated innovative process to mix various ingredients evenly to make powdered solid beverages and granules, and pack them into 10g/packages, dissolve them in about 150ml of warm water at 45 degrees, and drink them directly or take them through nasal feeding It can also be made into capsules, tablets by adding appropriate amount of supplementary materials or adding sweetener and black sesame powder to make quick and convenient food such as biscuits, which is convenient to carry and eat when going out. , divided into 10-65ml/bottle, drink one bottle every morning, noon, and 0.5 hours after dinner, all operations are carried out in a clean and dry environment that meets the requirements of "Good Manufacturing Practice for Formula Foods for Special Medical Purposes";

The characteristics of this medical formula food and its effects on the body are mainly manifested in the following aspects:

1. The present invention is developed according to the requirements of the "General Rules for Formulated Foods for Special Medical Purposes", combined with the physical characteristics of patients with constipation, and the research results of advanced physiology, medicine, nutrition and clinical application of Harvard University in the United States. It varies from person to person. , golden combination;

2. The present invention is based on the quintessence theory of traditional Chinese medicine (liver, spleen, and kidney are the main principle of the same coordination of the liver, spleen, and kidney) based on the essence of traditional Chinese medicine theory of "eliminating the middle and nourishing" and "balanced care", and adopts the essence of a variety of traditional Chinese medicine extracts for both medicine and food. Probiotics and short peptides are the main raw materials, and prebiotics, carbohydrates, oils with health care functions, amino acids, multivitamins and minerals are used as auxiliary materials. The organic combination of various ingredients integrates various functions, and through The synergistic effect between the active ingredients enhances the effect;

3. It has high absorbability. Using the formula of the present invention, the food prepared with appropriate proportions of various components will be in an isotonic state after being dissolved in a certain amount of water, and can quickly pass through the stomach to the small intestine, absorb quickly and completely, and can quickly Supplement the nutrition needed by patients with constipation;

4. The formula of the present invention adopts the extracts of various medicinal and edible Chinese herbal medicines, and contains a variety of functional active ingredients, which not only increases the concentration of functional factors, reduces the intake of various impurities, and helps to reduce the burden on the liver and kidneys, it has It has the function of enhancing the body's resistance, and also has the effects of moistening the intestines and laxative, nourishing yin and moistening dryness, nourishing the liver and kidney, clearing heat and eliminating accumulation, guiding stagnation and laxative, detoxifying and smoothing the intestines, and preventing and treating constipation;

5. The probiotics contained in the formula of the present invention, a variety of probiotics can maintain the balance of normal bacterial flora in the intestinal tract, inhibit the growth of pathogenic bacteria, prevent gastrointestinal disorders, etc., synthesize vitamins and amino acids in the intestinal tract, and improve the body's response to calcium ions Lactobacillus can significantly increase the content of intestinal mucosal immunoglobulin A (SIgA), which can regulate the local immunity of the intestinal mucosa of the body, regulate the stomach, Intestinal microecology can improve the utilization rate of calcium, phosphorus and iron, promote the absorption of iron and vitamin D, produce vitamin K and vitamin B, and reduce the absorption of cholesterol;

6. The formula food of the present invention uses food-derived bioactive short peptides from various sources as the nitrogen source, because short peptides can be absorbed without digestion, which is more conducive to the utilization of the body, and can effectively improve the negative nitrogen balance of patients with constipation. The derived short peptide can improve the structure and function of intestinal mucosal epithelial cells, and improve the absorption capacity of intestinal mucosa;

7. This formula adopts the achievements of our team in the past three years on the key technical research on the mechanism of probiotics colonization in the intestine, and improves the "Chinese medicine with the same source of medicine and food" compound formula that improves the colonization of probiotics in the intestine, combined with prebiotics The presence of the food can play a role in colonization, reduce the pH environment of the intestinal tract, and improve the intestinal adhesion ability of probiotic cells. Therefore, the composition of the food formula greatly enhances the colonization of exogenous probiotics;

8. The prebiotics contained in the formula of the present invention can inhibit the growth of spoilage bacteria by promoting the growth and reproduction of probiotics in the intestine, and at the same time form a protective barrier on the surface of the intestinal mucosa, which can resist the damage of intestinal spoilage bacteria to the intestinal mucosa , reduce the absorption of harmful substances in the intestines, can also promote intestinal peristalsis, accelerate the discharge of residual substances in the intestines, prevent constipation, and can also enhance the body's immunity by promoting the growth and reproduction of intestinal probiotics, short peptides, carbohydrates It has a synergistic effect with bioactive substances such as active polysaccharides;

9. The carbohydrates contained in the formula of the present invention are the three main nutrients that provide heat energy for the human body. They can be rapidly oxidized in the body to provide energy in a timely manner, avoiding the use of valuable protein to provide energy. Carbohydrates are also glycoproteins of cell membranes Glycolipids in nerve tissue and important components of deoxyribonucleic acid (DNA) that transmit genetic information, and glycogen contained in carbohydrates, when it is fully stored in the liver, liver cells are resistant to certain toxic chemicals and The toxins produced by various pathogenic microorganisms have strong detoxification ability;

10. The oil with health-care function contained in the formula of the present invention not only has a health-care effect on the human body, but also provides the energy required for normal life for the human body, so that the energy contained in every 100g of the final product of the present invention should not be less than 295kJ (70kcal);

11. The amino acid contained in the formula of the present invention is the basic unit of protein, endows protein with specific molecular structure and form, makes it have biochemical activity, helps the metabolism of various sulfur-containing compounds in the human body and the formazan contained in it The base can detoxify toxic substances or drugs by methylating them. It can repair muscles, control blood sugar, and provide energy to body tissues. It can also improve the absorption and utilization of food protein, achieve balanced nutrition, and promote growth and development;

12. The formula food of the present invention contains a variety of vitamins and minerals, which can quickly supplement the micronutrients needed by patients with constipation. After the short peptide is chelated with calcium, iron, zinc, etc., the absorption rate of mineral elements is increased;

13. The formula of the present invention does not contain fat and cholesterol, and can not increase the intake of fat and cholesterol while supplementing protein and micronutrients, and avoids the adverse effects of high-protein foods such as meat and eggs.

Detailed ways

The present invention will be further described below through the following examples, which will help to understand the present invention.

Implementation Case 1

To achieve the purpose of the present invention, the medical formula food for constipation is based on the physical characteristics of patients with constipation, and according to the essence theory of traditional Chinese medicine, it varies from person to person, and the golden compatibility is to use one, several or all of the extract essence and new Resource food, a variety of probiotics, and short peptides are the main raw materials, and medical formula food is made of prebiotics, carbohydrates, amino acids, oils and fats with health functions, multi-vitamins, and multi-minerals as auxiliary materials;

Formulated according to the following raw materials and their dosage, extracts for both medicine and food and new resource food: Dendrobium 14g, Senna 14g, Raw Rhubarb 14g, Astragalus 12g, Plantago 12g, Cordyceps militaris 12g, Hemp Seed 12g, Yu Liren 12g, perilla 12g, fat sea 10g, dandelion 10g, licorice 10g, cassia 10g, radish 10g, lily 10g, polygonatum 10g, aloe 8g, orange peel 8g, hawthorn 8g, mulberry 8g, almond 8g, ebony 8g, Seabuckthorn 6g, Luo Han Guo 6g, peach kernel 6g, sealwort 6g, red bean 6g, konjac 6g, malt 6g, houttuynia cordata 6g, honeysuckle 4g, spirulina 4g, dietary fiber 4g, yeast 3g, euglena 3g , chia seeds 2g , round 2g psyllium husk , 1g eucommia male flower , 1g milk mineral salt , 300g various probiotics, 200g short peptides, 100g prebiotics, 100g various amino acids, 100g carbohydrates, 100g oil with health care function, vitamin A0. 01g, Vitamin D0.000015g, Vitamin E0.12g, Vitamin K0.0075g, Vitamin K10.00001g, Vitamin C10.625g, Vitamin B10.016g, Vitamin B20.016g, Vitamin B60.015g, Vitamin B0.0023g, Vitamin Be, Vitamin Bu, niacin 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g , Zinc 6.2g, Selenium 0.00012g, Copper 0.007g, Manganese 0.018g, Iodine 0.00001g, Fluorine 0.00001g, Chromium 0.00001g, Molybdenum 0.00001g;

When making it, Dendrobium, senna, raw rhubarb, astragalus, plantain seed, hemp seed, yuliren, perilla seed, fat sea, dandelion, licorice, cassia seed, radish seed, lily, polygonatum odoratum, aloe vera, orange Peel, hawthorn, mulberry, dark plum, seabuckthorn, Luo Han Guo, sealwort, Houttuynia cordata, honeysuckle, euglena, chia seeds, psyllium husk, Eucommia male flower , add β-cyclodextrin after soaking, and use pre-hydrolyzed SBE After technical extraction, the powdery substance prepared by spray drying is added with short peptides extracted by biological enzymolysis, prebiotics, amino acids, red bean, konjac, malt, spirulina, dietary fiber, yeast, coix seed, almond, Cordyceps militaris , peach kernels, milk mineral salts, carbohydrates, oils with health care functions, multi-vitamins and minerals are crushed and mixed together, pasteurized for 1 hour, and then added with microencapsulated bifidobacteria, lactobacilli, thermophilic Streptococcus and mix them evenly to make powdered solid beverages and granules, and pack them into 10g/packages, dissolve them in about 150ml of warm water at 45 degrees, drink them directly or take them through nasal feeding; you can also add appropriate amount of additives Make capsules, tablets, or add sweeteners and black sesame powder to make biscuits and other quick and convenient food, which is easy to carry and eat when going out. If it is made into a beverage, spray drying is omitted, and less auxiliary materials are added. Packed into 10-65ml/ Drink one bottle every morning, noon, and 0.5 hours after dinner, and all operations are carried out in a clean and dry environment that meets the requirements of the "Good Manufacturing Practice for Formula Foods for Special Medical Purposes";

The production process of the present invention is the key technology of industrial production composed of microcapsules, biological enzymolysis, pre-hydrolysis SBE, spray drying and freeze-drying integration innovation; the microencapsulation protection technology effectively solves the problem of high temperature and strong acid gastric juice in the oral process. Inactivation of probiotics; use three-layer protein deep-buried microcapsule technology, and then mix evenly with traditional Chinese medicine extracts extracted by biological enzymatic hydrolysis or pre-hydrolysis SBE technology and microencapsulated to solve the problem of "multiple probiotics" and " The problem of the coexistence of the components of traditional Chinese medicine with the same origin of medicine and food has a certain resistance to high temperature and strong acid, which is conducive to the smooth passage of probiotics through gastric juice to the intestinal tract through oral administration, so that the efficacy of the product in preventing and treating constipation is significantly higher than that of similar products in the market. improve.

Implementation Case 2

The above medical formula food for constipation also includes the following components by weight, extracts for both medicine and food: 12g of Cordyceps militaris, 12g of Hemp Seed, 12g of Yu Liren, 12g of Semen Perilla, 10g of Plum Dahai, 10g of Dandelion, 10g of Licorice, Cassia Seed 10g, radish seed 10g, lily 10g, Polygonatum 10g, aloe vera 8g, orange peel 8g, hawthorn 8g, mulberry 8g, almond 8g, black plum 8g, seabuckthorn 6g, Luo Han Guo 6g, peach kernel 6g, sealwort 6g, red bean 6g, konjac 6g, Malt 6g, Houttuynia cordata 6g, honeysuckle 4g, spirulina 4g, dietary fiber 4g, yeast 3g, euglena 3g , chia seeds 2g , psyllium husk 2g , Eucommia male flower 1g , milk mineral salt 1g , prebiotics 350g, 300g of probiotics, 150g of short peptides, 100g of various amino acids, 100g of carbohydrates, 100g of oils and fats with health functions, 50g of carbohydrates, oils with health functions, 25g of vitamins and minerals.

Implementation Case Three

The above-mentioned medical formula food for constipation also includes the following components by weight: 400g of extracts of Chinese medicines for both medicine and food and new resource food, 350g of prebiotics, 350g of short peptides, 300g of carbohydrates, and 300g of oil with health care function , 100g of various amino acids, 25g of multivitamins and minerals; the energy contained in each 100g should not be less than 295kJ (70kcal).

Implementation Case Four

The above-mentioned specific medical formula food for constipation also includes the following components by weight: 700g of prebiotics, 500g of short peptides, 300g of carbohydrates, 300g of multiple probiotics, 100g of multiple amino acids, 25g of multivitamins and minerals; The energy contained should not be less than 295kJ (70kcal).

Implementation Case Five

The above medical formula food for constipation also includes the following components by weight: 500g of prebiotics, 350g of short peptides, 300g of carbohydrates, 250g of multiple probiotics, 100g of multiple amino acids, 25g of multivitamins and minerals; The energy should not be less than 295kJ (70kcal).

Implementation Case Six

The above-mentioned medical formula food for constipation also includes the following components by weight: 350g of short peptides, 350g of prebiotics, 300g of carbohydrates, 300g of oils and esters with health care functions, 100g of multiple amino acids, 25g of multivitamins and minerals; The energy contained should not be less than 295kJ (70kcal).

Claims (10)

1. Constipation medical formula food, which is characterized by combining the physical characteristics of patients with constipation, according to the essence theory of traditional Chinese medicine, and varies from person to person. Resource food, a variety of probiotics, short peptides as the main raw materials, medical formula food made of prebiotics, carbohydrates, amino acids, oils with health functions, multi-vitamins, and multi-minerals as auxiliary materials; Formulated according to the following raw materials and their dosage, extracts for medicinal and edible purposes and new resource food: Dendrobium 14g, Senna 14g, Raw Rhubarb 14g, Astragalus 12g, Plantago 12g, Cordyceps militaris 12g, Hemp Seed 12g, Yu Liren 12g, perilla 12g, fat sea 10g, dandelion 10g, licorice 10g, cassia 10g, radish 10g, lily 10g, polygonatum 10g, aloe 8g, orange peel 8g, hawthorn 8g, mulberry 8g, almond 8g, ebony 8g, Seabuckthorn 6g, Luo Han Guo 6g, peach kernel 6g, sealwort 6g, red bean 6g, konjac 6g, malt 6g, houttuynia cordata 6g, honeysuckle 4g, spirulina 4g, dietary fiber 4g, yeast 3g, euglena 3g , chia seeds 2g , round 2g psyllium husk , 1g eucommia male flower , 1g milk mineral salt , 300g various probiotics, 200g short peptides, 100g prebiotics, 100g various amino acids, 100g carbohydrates, 100g oil with health care function, vitamin A0. 01g, Vitamin D0.000015g, Vitamin E0.12g, Vitamin K0.0075g, Vitamin K10.00001g, Vitamin C10.625g, Vitamin B10.016g, Vitamin B20.016g, Vitamin B60.015g, Vitamin B0.0023g, Vitamin Be, Vitamin Bu, niacin 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g , Zinc 6.2g, Selenium 0.00012g, Copper 0.007g, Manganese 0.018g, Iodine 0.00001g, Fluorine 0.00001g, Chromium 0.00001g, Molybdenum 0.00001g; When making it, Dendrobium, senna, raw rhubarb, astragalus, plantain seed, hemp seed, yuliren, perilla seed, fat sea, dandelion, licorice, cassia seed, radish seed, lily, polygonatum odoratum, aloe vera, orange Peel, hawthorn, mulberry, dark plum, seabuckthorn, Luo Han Guo, sealwort, Houttuynia cordata, honeysuckle, euglena, chia seeds, psyllium husk, Eucommia male flower , add β-cyclodextrin after soaking, and use pre-hydrolyzed SBE After technical extraction, the powdery substance prepared by spray drying is added with short peptides extracted by biological enzymolysis, prebiotics, amino acids, red bean, konjac, malt, spirulina, dietary fiber, yeast, coix seed, almond, Cordyceps militaris , peach kernels, milk mineral salts, carbohydrates, oils with health functions, multi-vitamins and minerals are crushed and mixed together, pasteurized for 1 hour, and then added with microencapsulated bifidobacteria, lactobacilli, thermophilic Streptococcus and mix evenly to make powdered solid beverages and granules, and pack them into 10g/packages, dissolve them in about 150ml of warm water at 45 degrees, drink them directly or ingest them through nasal feeding; you can also add appropriate amount of additives Make capsules, tablets, or add sweeteners and black sesame powder to make biscuits and other quick and convenient food, which is easy to carry and eat when going out. If it is made into a beverage, spray drying is omitted, and less auxiliary materials are added. Packed into 10-65ml/ Drink one bottle every morning, noon, and 0.5 hours after dinner, and all operations are carried out in a clean and dry environment that meets the requirements of the "Good Manufacturing Practice for Formula Foods for Special Medical Purposes"; The production process of the present invention is characterized by the integration and innovation of microcapsules, biological enzymolysis, pre-hydrolysis SBE, spray drying and freeze-drying, which constitute the key technology of industrial production; the microencapsulation protection technology effectively solves the problem of high temperature and Inactivation of probiotics by strong acid gastric juice; three-layer protein deep-buried microcapsule technology is used, and then mixed with traditional Chinese medicine extracts extracted by biological enzymatic hydrolysis or pre-hydrolysis SBE technology and microencapsulated to solve the problem of "multiple probiotics". The problem of coexistence with the components of "medicine and food homologous traditional Chinese medicine" has a certain resistance to high temperature and strong acid properties, which is conducive to the smooth passage of probiotics through the gastric juice to the intestinal tract through oral administration, so that the efficacy of the product in preventing and treating constipation is comparable to that of similar products in the market significantly improved compared to . 2. The medical formula food for constipation according to claim 1, characterized in that the said medicinal and edible Chinese herbal medicine extract and new resource food are: dendrobium, senna, raw rhubarb, astragalus, psyllium, hemp Ren, Yu Li Ren, Su Zi, Panda Hai, Dandelion, Licorice, Cassia, Radix, Lily, Polygonatum Polygonatum, Aloe Vera, Orange Peel, Hawthorn, Mulberry, Black Plum, Sea Buckthorn, Luo Han Guo, Polygonatum, Houttuynia cordata, Honeysuckle, Euglena, One, several or all of chia seeds, psyllium husks, eucommia male flowers , red bean, konjac, malt, spirulina, dietary fiber, yeast, coix seed, almond, cordyceps militaris, peach kernel, milk mineral salt mix. 3. The medical formula food for constipation according to claim 1, characterized in that it can be prepared into powder, granule, capsule, tablet and beverage food according to the formula. 4. The medical formula food for constipation according to claim 1, further comprising the following components by weight: 400g of Chinese medicine extract essence and new resource food, 350g of prebiotics, 350g of short peptides, carbohydrates 300g of compound, 300g of oil with health care function, 100g of various amino acids, 25g of multivitamins and minerals; the energy contained in each 100g should not be less than 295 kJ (70 kcal). 5. The constipation medicine formula food according to claim 1, is characterized in that described probiotics are: Bifidobacterium, Lactobacillus, Streptococcus thermophilus, Pediococcus lactis, wherein one, several or all mix; The bifidobacterium above refers to: Bifidobacterium adolescentis, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium animal (Bifidobacterium lactis); The Lactobacillus above refers to: Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus , Lactobacillus reuteri, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus crispatus, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus reuteri. 6. The medical formula food for constipation according to claim 1, characterized in that the prebiotics are: the extraction mixture of yam, poria cocos, barley, gallinacea, gorgon, inulin, raffinose oligosaccharides, trehalose , stachyose, yeast, isomaltooligosaccharides, fructooligosaccharides, soybean oligosaccharides, xylooligosaccharides, a mixture of several or all of them. 7. constipation medical formula food according to claim 1, is characterized in that described amino acid is: L-glutamine, gamma-aminobutyric acid, pearl peptide powder, methionine, isoleucine, tyrosine, A mixture of one, several or all of phenylalanine, lysine, arginine, histidine, tryptophan, citrulline, ornithine, and taurine. 8. The medical formula food for constipation according to claim 1, characterized in that the carbohydrate described in the present invention refers to L-arabinose, fructose, mussel polysaccharide, resistant dextrin, shell Oligosaccharides, yeast β-glucan, polyfructose, galactose, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen, one, several or all mixed. 9. The medical formula food for constipation according to claim 1, characterized in that the described oil with health care function is: linseed oil, peony seed oil, samara oil, milk thistle seed oil, phytosterol ester, Royal rice oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, sucrose polyester, DHA algae oil, krill oil, Suaeda salsa seed oil, saponica fruit oil, arachidonica fruit oil, Medium chain triglycerides, yellow gelatin, eucalyptus fruit oil, almond oil, medium and long chain fatty acid edible oil, ingot maple seed oil, epigallocatechin gallate, diglyceride oil, lutein One, several or all of the esters are mixed. 10. The medical formula food for constipation according to claim 1, characterized in that the short peptide is: marine collagen peptide, corn oligopeptide, wheat oligopeptide, marine bone peptide, soybean protein peptide, whey protein One, several or all of peptides and ovalbumin peptides are mixed.