CN106721247B - A feed additive that can promote intestinal development of weaned piglets - Google Patents

Abstract

The invention discloses a feed additive which can promote the intestinal development of weaned piglets. The additive is composed of the following components by weight: 1-6 parts of prebiotics, 1-6 parts of probiotics, and 1-5 parts of nucleotides . The feed additive of the invention realizes a reasonable ratio of prebiotics, probiotics and nucleotides, can effectively improve the intestinal development of weaned piglets, enhance immunity, and reduce the impact of weaning stress on intestinal metabolism of piglets; Piglet diarrhea, improve survival rate, replace antibiotics; improve feed conversion rate, improve economic value, etc. This is of great significance to modern scientific, intensive and large-scale pig production.

Description

A feed additive that can promote intestinal development of weaned piglets

technical field

The invention relates to the field of feed additives, in particular to a feed additive that can promote the intestinal development of weaned piglets.

Background technique

The research and application of feed formula for early weaned piglets is directly related to the growth and future performance of weaned piglets. In my country, compared with the traditional weaning age of piglets, weaning at 21-35 days is generally called early weaning, and weaning before 21 days is called super-early weaning. However, early weaned piglets, especially ultra-early weaned piglets, face the problems of immaturity of digestive tract, poor gastrointestinal function, immune insufficiency, and low disease resistance, and weaning is also related to the physiological, psychological, environmental and nutritional status of piglets. These changes will cause allergies, decreased feed intake, low feed utilization, and delayed growth and development in piglets, which will seriously affect the economic benefits of the pig industry.

The combined use of prebiotics, probiotics and nucleotides can effectively make up for the imperfect development of the digestive system of weaned piglets, promote the rapid development and maturity of their gastrointestinal digestive system, and ensure the good growth of weaned piglets.

A prebiotic is a dietary supplement that has a beneficial effect on the host by selectively stimulating the growth and activity of bacteria in one or a few colonies, thereby improving the health of the host's non-digestible food components. Successful prebiotics are mostly fermented by gut flora while passing through the upper gastrointestinal tract without being digested. Most importantly, it only stimulates the growth of beneficial flora, not harmful bacteria with potentially pathogenic or putrefactive activity.

Probiotics are a class of active microorganisms that are beneficial to the host. They are the general term for active beneficial microorganisms that are colonized in the intestinal tract and reproductive system of the body and can produce definite health effects to improve the host's microecological balance and play a beneficial role.

During periods of rapid growth, stress, and immunosuppression, animals have an increased need for nucleotides, all of which are encountered in newly weaned piglets, when metabolically active organs and tissues require large amounts of exogenous nucleosides. acid supply. However, weaned piglets lack the energy and glutamine required for nucleotide synthesis, which results in a shortage of endogenous nucleotides and needs to be supplemented with exogenous nucleotides.

At present, there are many reports on the single application of prebiotics, probiotics and nucleotides, but the combined application of these three is rarely reported.

SUMMARY OF THE INVENTION

In order to solve the problems existing in the feed for weaned piglets at present, the present invention provides a feed additive which can promote the intestinal development of weaned piglets. The additive is added to the daily feed of piglets according to a certain amount, which can effectively relieve the stress response of weaning piglets and improve the production performance of piglets.

In order to solve the above-mentioned technical problems, the present invention adopts the following technical solutions:

A feed additive that can promote the intestinal development of weaned piglets, the additive is composed of the following components by weight:

1 to 6 servings of prebiotics,

1 to 6 servings of probiotics,

1 to 5 nucleotides.

The additive preferably consists of the following components by weight:

4 servings of prebiotics,

6 servings of probiotics,

3 copies of nucleotides.

Wherein, the prebiotic is composed of the following components by weight: 1-3 parts of fructooligosaccharides and 1-3 parts of galactooligosaccharides, preferably composed of the following components by weight: 3 parts of fructooligosaccharides and 1 part galactooligosaccharide.

Wherein, the probiotics are composed of the following components by weight: 1 to 3 parts of Lactobacillus fermentum and 1 to 3 parts of Bacillus subtilis, preferably the following components by weight: 3 parts of Lactobacillus fermentum and 1 to 3 parts of Bacillus subtilis 3 copies of Bacillus subtilis.

Wherein, the probiotics are powder preparations, and the viable count of the pure bacterial powder of each strain is not less than 1*1010cfu/g.

Wherein, the nucleotides are nucleotides obtained by using ribonucleic acid as a raw material, enzymatic hydrolysis to obtain a mixed nucleotide liquid, and direct spray drying.

The nucleotides comprise the following components by weight: 50-70% of nucleotides, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash, and 5-9% of moisture.

Wherein, the added amount of the feed additive in the feed of weaned piglets is 0.05-0.5 wt %, preferably 0.3 wt %.

The application of the above-mentioned feed additive in promoting the intestinal development of weaned piglets also falls within the protection scope of the present invention.

Beneficial effect: Compared with the prior art, the feed additive technology that can promote the intestinal development of weaned piglets of the present invention has the following advantages:

The additive of the invention is composed of prebiotics, probiotics and nucleotides, and realizes a reasonable ratio of prebiotics, probiotics and nucleotides. It can effectively improve the intestinal development of weaned piglets, enhance immunity, and reduce the impact of weaning stress on intestinal metabolism of piglets; it can reduce diarrhea of weaned piglets, improve survival rate, and replace antibiotics; it can improve feed conversion rate and economic value, etc. . This is of great significance to modern scientific, intensive and large-scale pig production.

Detailed ways

The present invention can be better understood from the following examples. However, those skilled in the art can easily understand that the contents described in the embodiments are only used to illustrate the present invention, and should not and will not limit the present invention described in detail in the claims.

In the following examples, the probiotics are powder preparations, and the viable count of the pure bacterial powder of each strain is not less than 1*1010cfu/g. The nucleotides are obtained by using ribonucleic acid as a raw material, enzymatically hydrolyzing to obtain a mixed nucleotide liquid, and directly spray-drying the nucleotides.

The nucleotides comprise the following components by weight: 50-70% of nucleotides, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash, and 5-9% of moisture.

Examples 1 to 4

The component proportions of the feed additives are shown in Table 1, and parts are parts by weight.

Table 1

Example 5:

Experimental animals and groups:

A total of 300 weaned piglets with similar body weight and about 30 days of age were selected and randomly divided into 5 groups according to their initial body weight, namely control group and experimental group 1-5. There were 6 replicates in each group, with 10 pigs in each replicate. Each treatment was fed the corresponding diet, and the experiment was ad libitum to eat and drink food and water. The feeding and management methods were determined according to the specific conditions of the experimental site.

Control group: The basal ration is determined according to the conditions of the test site, and no changes are made, and its formula and nutritional components are shown in Table 2;

Test group 1: 0.1wt% of the feed additive in Example 1 was added to the basic diet formula;

Test group 2: 0.1wt% of the feed additive in Example 2 was added to the basic diet formula;

Test group 3: 0.1wt% of the feed additive in Example 3 was added to the basic diet formula;

Test group 4: 0.1wt% of the feed additive in Example 4 was added to the basic diet formula;

Table 2 Basic diet formula and nutrients

¹ Each kilogram of premix contains: Vitamin A, 160,000 IU; Vitamin D, 35,000 IU; Vitamin E, 550 IU; Vitamin K, 45mg; Vitamin B1, 30mg; Vitamin B2, 150mg; Vitamin B6, 20mg; Vitamin B12, 0.4mg; Calcium Pantothenate, 100mg; Niacin, 390mg; Folic Acid, 20mg; Biotin, 0.2mg; Iron, 3.0g; Copper, 3.6g; Manganese, 0.75g; Zinc, 3.0g; Iodine, 35.0mg; Selenium, 7.0 mg; Lysine, 3.5%; Salt, 8%; Choline, 8.0 g/kg; Calcium, 12%; Total Phosphorus, 3.0%.

² Produced by Wuhan Xinhua Yang Biological Co., Ltd., each gram of compound enzyme product contains: acid protease, 1400IU; neutral protease, 600IU; amylase, 2500IU; xylanase, 800IU; β-mannanase, 3600IU; - Glucanase, 200IU; Xylanase, 800IU.

³ Produced by Chongqing Jiamei Perfume Co., Ltd., butyric acid ≥1%, Maillart reactant ≥5%, refined squid extract ≥5%.

The fasting body weight of the piglets was measured on the start and end days of the experiment, the feed intake was recorded, and the daily gain and feed utilization were calculated. The diarrhea of piglets in the whole process was observed and recorded, and the diarrhea rate was calculated. The test results are shown in Table 3.

table 3

It can be seen from the above table that the experimental groups 1, 2, 3, and 4 are prebiotic addition groups, and both the feed-to-weight ratio and the diarrhea rate are significantly lower than those of the control group, and the experimental group 3 has the best effect.

Embodiments 6 to 9:

The component proportions of the feed additives are shown in Table 4, and parts are parts by weight.

Table 4

Example 10:

Experimental animals and groups:

A total of 300 weaned piglets with similar body weight and about 30 days of age were selected and randomly divided into 5 groups according to their initial body weight, namely control group and experimental group 1-5. There were 6 replicates in each group, with 10 pigs in each replicate. Each treatment was fed the corresponding diet, and the experiment was ad libitum to eat and drink food and water. The feeding and management methods were determined according to the specific conditions of the experimental site.

Control group: The basal ration is determined according to the conditions of the test site, and no changes are made, and its formula and nutritional components are shown in Table 2;

Test group 5: 0.1wt% of the feed additive in Example 6 was added to the basic diet formula;

Test group 6: 0.1wt% of the feed additive in Example 7 was added to the basic diet formula;

Test group 7: 0.1wt% of the feed additive in Example 8 was added to the basic diet formula;

Test group 8: 0.1wt% of the feed additive in Example 9 was added to the basic diet formula;

The fasting body weight of the piglets was measured on the start and end days of the experiment, the feed intake was recorded, and the daily gain and feed utilization were calculated. The diarrhea of piglets in the whole process was observed and recorded, and the diarrhea rate was calculated. The test results are shown in Table 5:

table 5

It can be seen from the above table that the test groups 5, 6, 7, and 8 are probiotic addition groups, and both the feed-to-weight ratio and the diarrhea rate are significantly lower than those of the control group, and the test group 8 has the best effect.

Examples 11 to 14:

The component proportions of the feed additives are shown in Table 6, and parts are parts by weight.

Table 6

Example 15:

Experimental animals and groups:

A total of 300 weaned piglets with similar body weight and about 30 days of age were selected and randomly divided into 5 groups according to their initial body weight, namely control group and experimental group 1-5. There were 6 replicates in each group, 10 pigs in each replicate, and each treatment was fed with the corresponding diet. The whole experiment was ad libitum to eat food and water, and the feeding and management methods were determined according to the specific conditions of the experimental site. Control group: The basal ration is determined according to the conditions of the test site, and no changes are made, and its formula and nutritional components are shown in Table 2;

Test group 9: 0.2wt% of the feed additive in Example 11 was added to the basic diet formula;

Test group 10: 0.2wt% of the feed additive in Example 12 was added to the basic diet formula;

Test group 11: 0.2wt% of the feed additive in Example 13 was added to the basic diet formula;

Test group 12: 0.2wt% of the feed additive in Example 14 was added to the basic diet formula;

The fasting body weight of the piglets was measured on the start and end days of the experiment, the feed intake was recorded, and the daily gain and feed utilization were calculated. The diarrhea of piglets in the whole process was observed and recorded, and the diarrhea rate was calculated. The test results are shown in Table 7:

Table 7

As can be seen from the above table, test group 9 is a combination of prebiotics and probiotics, and test groups 10, 11, and 12 are a combination of prebiotics, probiotics and nucleotides. The diarrhea rate was significantly lower than that of the control group and the experimental group 9, of which the experimental group 11 had the best effect.

Example 16:

Experimental animals and groups:

A total of 420 weaned piglets about 30 days old with similar body weight were selected and randomly divided into 7 groups according to their initial body weight, namely control group and experimental group 1-7. There were 6 replicates in each group, with 10 pigs in each replicate. Each treatment was fed the corresponding diet, and the experiment was ad libitum to eat and drink food and water. The feeding and management methods were determined according to the specific conditions of the experimental site.

Test group 13: 0.05wt% of the feed additive in Example 13 was added to the basic diet formula;

Test group 14: 0.1wt% of the feed additive in Example 13 was added to the basic diet formula;

Test group 15: 0.2wt% of the feed additive in Example 13 was added to the basic diet formula;

Test group 16: 0.3wt% of the feed additive in Example 13 was added to the basic diet formula;

Test group 17: 0.4wt% of the feed additive in Example 23 was added to the basic diet formula;

Test group 18: 0.5wt% of the feed additive in Example 13 was added to the basic diet formula;

The fasting body weight of the piglets was measured on the start and end days of the experiment, the feed intake was recorded, and the daily gain and feed utilization were calculated. The diarrhea of piglets in the whole process was observed and recorded, and the diarrhea rate was calculated. The test results are as follows:

It can be seen from the above table that when the total addition amount of prebiotics, probiotics and nucleotides is 0.3 wt%, both the feed-to-weight ratio and the diarrhea rate are significantly reduced.

To sum up, the optimal formula of the present invention is as follows: components by mass of prebiotics: 3 parts of fructooligosaccharides and 1 part of galactooligosaccharides. Components of probiotics by mass: 3 parts of fermented Lactobacillus and 3 parts of Bacillus subtilis. Nucleotide quality components are 3 parts. The total amount added in the feed was 0.3 wt%.

Claims (2)

1. The feed additive capable of promoting intestinal development of weaned piglets is characterized by comprising the following components in parts by weight:

3 parts of fructo-oligosaccharide;

1 part of galacto-oligosaccharide;

3 parts of lactobacillus fermentum;

3 parts of bacillus subtilis;

1-5 parts of nucleotide;

the lactobacillus fermentum and the bacillus subtilis are powder preparations, and the viable count of the pure bacterial powder of each strain is not less than 1 x 10¹⁰cfu/g；

The nucleotide is prepared by taking ribonucleic acid as a raw material, performing enzymatic hydrolysis to obtain mixed nucleotide liquid, and directly performing spray drying;

the nucleotide comprises the following components in percentage by weight: 50-70% of nucleotide, 5-15% of crude protein, 2-6% of crude fat, 12-25% of ash and 5-9% of water.

2. The feed additive for promoting intestinal development of weaned piglets according to claim 1, wherein the feed additive is added to the feed for weaned piglets in an amount of 0.05-0.5 wt%.