CN106668130A - Preparation process for agent for treating gout - Google Patents
Preparation process for agent for treating gout Download PDFInfo
- Publication number
- CN106668130A CN106668130A CN201710024085.0A CN201710024085A CN106668130A CN 106668130 A CN106668130 A CN 106668130A CN 201710024085 A CN201710024085 A CN 201710024085A CN 106668130 A CN106668130 A CN 106668130A
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- CN
- China
- Prior art keywords
- viciae fabae
- semen viciae
- processing technology
- peel
- plant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation process for an agent for treating gout, which includes the following steps: the plant, seeds, broad bean coat and broad been skin of broad beans are adopted as materials, and are extracted by methanol or ethanol or acid aqueous solution and the like, and the agent is used for treating gout. The agent for treating gout prepared by the process utilizes the natural broad bean products as the materials, has good efficacy and no side effects, and is more suitable for use by patients.
Description
Technical field
The present invention relates to medicine, field of food, more particularly to a kind of processing technology for treating gout agent.
Background technology
Gout is because purine metabolic disturbance causes one group of disease of injuries of tissues and organs.Often with joint symptoms it is clinically
First presentation, and (the clinical risk Logistio researchs of the big gout of Huang Yanhong, Lv Yan of the internal organs such as kidney can be involved
ChineseGeneralPractice2010.1 1A phase 52-56 of volume 13)；At this stage mainly with Colchicine, allopurinol etc.
Drug combination is treated, the medicament mixed such as useful Herba Lysimachiae among the people treat gout report (A Naerguli. Ma He
Wood carries nguktrum to be bought and carries. and Chinese mugwort buys the phase of progress National medicine magazine the 2008.8, the 8th that natural drug treats gout that carries
Or 45-48). but these Therapeutic Method are larger to hepar damnification, or effect is not obvious.And pass through a large amount of to the national doctor of our province
The excavation of medicine, searches out Yi nationality, distributed over Yunnan, Sichuan and Guizhou's method having with Testa Viciae fabae, peel of Semen Viciae fabae treatment gout among the people, by research, contains in Testa Viciae fabae
There are flavone, alkaloid isoreactivity composition, Jing preliminary tests, to treating the effect of gout tool.
The content of the invention
A kind of processing technology for treating gout agent, its composition includes：
(1) with the plant of Semen Viciae fabae, seed and peel of Semen Viciae fabae, Testa Viciae fabae as raw material；
(2) extracted using methanol or ethanol or acidic aqueous solution；
(3) reclaim after methanol or ethanol or adjust pH value to cause after the precipitation (or insoluble matter) of alkalescence, to be processed into what is conveniently taken
Dosage form, form.
Preferably, the step (1) is with the plant of Semen Viciae fabae, seed or peel of Semen Viciae fabae, Testa Viciae fabae as raw material.
Preferably, the step (2) adopts methanol or concentration of alcohol scope 70-100%.
Preferably, the solvent of step (3) the regulation pH is adopted with hydrochloric acid or acetum.
Preferably, the proportioning of the raw material is combined as：Plant 30-70%, the seed 40-70% of Semen Viciae fabae or peel of Semen Viciae fabae
30-70%, Testa Viciae fabae 40-70%, or Bean Plant, seed, Testa Viciae fabae or peel of Semen Viciae fabae is used alone.
Preferably, the acidic aqueous solution of the step (2) is hydrochloric acid or aqueous acetic acid.
Beneficial effect：The invention provides a kind of processing technology for treating gout agent, comprises the following steps：Using Semen Viciae fabae
Plant, seed and peel of Semen Viciae fabae, Testa Viciae fabae be raw material, Jing after methanol or ethanol or acidic aqueous solution etc. are extracted, for treating pain
Wind, treatment gout agent prepared by this technique, by the use of natural Semen Viciae fabae product as raw material, good drug efficacy, has no side effect, more
The use of suitable patient, the step (1) with the plant of Semen Viciae fabae, seed or peel of Semen Viciae fabae, Testa Viciae fabae as raw material, the technology utilization silkworm
The various natural products of bean as raw material, more natural safety, methanol or concentration of alcohol scope 50- that the step (2) adopts
80%, the ethanol under the concentration can fully extract the effective ingredient in Semen Viciae fabae, and the step (3) adjusts the solvent of pH and adopts
Potassium dihydrogen phosphate and potassium hydroxide buffer system, the composition can be finely adjusted pH value of the medicine in preparation process, convenient
The preparation of medicine, the proportioning of the raw material is combined as：Plant 30-70%, the seed 40-70% of Semen Viciae fabae or peel of Semen Viciae fabae 30-
70%th, Testa Viciae fabae 40-70%, height composition part can be effectively accomplished good drug effect, and the acidic aqueous solution of step (2) is acetic acid
Aqueous solution, the acidic extraction liquid of this food stage can either extract effective ingredient in Semen Viciae fabae, and low to the harm of human body.
Specific embodiment
Technological means, creation characteristic, reached purpose and effect to make present invention realization is easy to understand, with reference to
Specific embodiment, is expanded on further the present invention.
Embodiment 1：
A kind of processing technology for treating gout agent, its processing technique includes：
(1) with the plant of Semen Viciae fabae, seed or peel of Semen Viciae fabae, Testa Viciae fabae as raw material, the proportioning of raw material is combined as：Peel of Semen Viciae fabae
35%, Testa Viciae fabae 65%.
(2) extracted using ethanol；
(3) reclaim after ethanol, be processed into dosage form, the form conveniently taken.
Embodiment 2：
A kind of processing technology for treating gout agent, its processing technique includes：
(1) with the plant of Semen Viciae fabae, seed or peel of Semen Viciae fabae, Testa Viciae fabae as raw material, the proportioning of raw material is combined as：The plant of Semen Viciae fabae
65%th, seed 35%；
(2) extracted using 75% ethanol；
(3) reclaim after ethanol, be processed into dosage form, the form conveniently taken.
Embodiment 3：
A kind of processing technology for treating gout agent, its processing technique includes：
(1) with the plant of Semen Viciae fabae, seed or peel of Semen Viciae fabae, Testa Viciae fabae as raw material, the proportioning of raw material is combined as：Peel of Semen Viciae fabae
55%th, Testa Viciae fabae 45%；
(2) extracted using aqueous acetic acid；
(3) pH value is adjusted to cause to be adjusted after the precipitation (or insoluble matter) of alkalescence the solvent of pH using potassium dihydrogen phosphate and hydroxide
Potassium buffer system, is processed into dosage form, the form conveniently taken.
The sample for extracting each embodiment is tested and analyzed, and is compareed with prior art, draws following data：
| Flavones content | Alkaloid | Side effect height | Effective ingredient | |
| Embodiment 1 | 1.05g/kg | 2.15g/kg | It is low | Flavone, alkaloid |
| Embodiment 2 | 0.94g/kg | 1.77g/kg | It is low | Flavone, alkaloid |
| Embodiment 3 | 0.89g/kg | 1.53g/kg | It is low | Flavone, alkaloid |
| Existing index | 0.56g/kg | 0.93g/kg | Office | Colchicine, allopurinol |
Can be drawn according to above table data, when 1 parameter of embodiment is implemented, the treatment gout agent for obtaining, it is yellow
Ketone content is 1.05g/kg, and alkaloid 2.15g/kg, side effect is low, and effective ingredient is flavone and alkaloid, and existing skill
It is 0.56g/kg that art standard is flavones content, and alkaloid 0.93g/kg, side effect is high, and effective ingredient is for Colchicine and not
Fast alcohol, therefore the treatment gout agent that the processing technology of present invention treatment gout agent is prepared is higher containing effective ingredient, effectively
Composition is more natural, and side effect is lower, and in contrast the present invention has significantly superiority.
The invention provides a kind of processing technology for treating gout agent, comprises the following steps：Using the plant of Semen Viciae fabae, plant
Son and peel of Semen Viciae fabae, Testa Viciae fabae are raw material, Jing after methanol or ethanol or acidic aqueous solution etc. are extracted, for treating gout, this technique
The treatment gout agent of preparation, by the use of natural Semen Viciae fabae product as raw material, good drug efficacy, has no side effect, and is more suitable for patient
Use, the step (1) with the plant of Semen Viciae fabae, seed or peel of Semen Viciae fabae, Testa Viciae fabae as raw material, the various days of technology utilization Semen Viciae fabae
So product is used as raw material, more natural safety, concentration of alcohol scope 70-100% that the step (2) adopts, under the concentration
Ethanol can fully extract the effective ingredient in Semen Viciae fabae, and the step (3) adjusts the solvent of pH using hydrochloric acid or acetum,
The composition can be finely adjusted pH value of the medicine in preparation process, facilitate the preparation of medicine, the proportioning group of the raw material
It is combined into：Plant 30-70%, the seed 40-70% of Semen Viciae fabae or peel of Semen Viciae fabae 30-70%, Testa Viciae fabae 40-70%, height composition part energy
Good drug effect is enough effectively accomplished, the acidic aqueous solution of step (2) is hydrochloric acid or aqueous acetic acid, the acidity of this food stage
Extracting solution can either extract effective ingredient in Semen Viciae fabae, and low to the harm of human body.
Above-described is only the preferred embodiment of the present invention, it is noted that for one of ordinary skill in the art
For, without departing from the concept of the premise of the invention, some deformations and improvement can also be made, these belong to the present invention
Protection domain.
Claims (6)
1. a kind of processing technology for treating gout agent, it is characterised in that its processing technique includes：
(1) with the plant of Semen Viciae fabae, seed and peel of Semen Viciae fabae, Testa Viciae fabae as raw material；
(2) extracted using methanol or ethanol or acidic aqueous solution；
(3) reclaim after methanol or ethanol or adjust pH value to cause after the precipitation (or insoluble matter) of alkalescence, be processed into conveniently take dosage form,
Form.
2. it is according to claim 1 treatment gout agent processing technology, it is characterised in that the step (1) is with Semen Viciae fabae
Plant, seed or peel of Semen Viciae fabae, Testa Viciae fabae be raw material.
3. the processing technology for the treatment of gout agent according to claim 1, it is characterised in that what the step (2) adopted
Methanol or concentration of alcohol scope 70-100%.
4. the processing technology for the treatment of gout agent according to claim 1, it is characterised in that the step (3) adjusts pH
Solvent adopt with hydrochloric acid or acetum.
5. it is according to claim 2 treatment gout agent processing technology, it is characterised in that the raw material proportioning combination
For：Plant 30-70%, the seed 40-70% of Semen Viciae fabae or peel of Semen Viciae fabae 30-70%, Testa Viciae fabae 40-70%, or silkworm is used alone
Bean plant, seed, Testa Viciae fabae or peel of Semen Viciae fabae.
6. it is according to claim 1 treatment gout agent processing technology, it is characterised in that the acidity of the step (2)
Aqueous solution is hydrochloric acid or aqueous acetic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710024085.0A CN106668130A (en) | 2017-01-16 | 2017-01-16 | Preparation process for agent for treating gout |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710024085.0A CN106668130A (en) | 2017-01-16 | 2017-01-16 | Preparation process for agent for treating gout |
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| Publication Number | Publication Date |
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| CN106668130A true CN106668130A (en) | 2017-05-17 |
Family
ID=58859001
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710024085.0A Pending CN106668130A (en) | 2017-01-16 | 2017-01-16 | Preparation process for agent for treating gout |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10300100B1 (en) | 2018-09-27 | 2019-05-28 | King Saud University | Extract of Vicia faba beans |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401380A (en) * | 2002-09-05 | 2003-03-12 | 南京大学 | Anti-gout composition and preparing process thereof |
-
2017
- 2017-01-16 CN CN201710024085.0A patent/CN106668130A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401380A (en) * | 2002-09-05 | 2003-03-12 | 南京大学 | Anti-gout composition and preparing process thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张晶，袁珂主编: "《中药化学》", 30 April 2015, 中国农业大学出版社 * |
| 董小萍，罗永明主编: "《天然药物化学》", 28 February 2015, 中国医药科技出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10300100B1 (en) | 2018-09-27 | 2019-05-28 | King Saud University | Extract of Vicia faba beans |
| US10568921B1 (en) | 2018-09-27 | 2020-02-25 | King Saud University | Extract of Vicia faba beans |
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Application publication date: 20170517 |