CN106667950A - Pharmaceutical capsule material - Google Patents
Pharmaceutical capsule material Download PDFInfo
- Publication number
- CN106667950A CN106667950A CN201611072983.5A CN201611072983A CN106667950A CN 106667950 A CN106667950 A CN 106667950A CN 201611072983 A CN201611072983 A CN 201611072983A CN 106667950 A CN106667950 A CN 106667950A
- Authority
- CN
- China
- Prior art keywords
- parts
- capsule
- capsule material
- glycerol
- pharmaceutical capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 17
- 239000000463 material Substances 0.000 title claims abstract description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 19
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 13
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 13
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 13
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 13
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920001817 Agar Polymers 0.000 claims abstract description 7
- 108010010803 Gelatin Proteins 0.000 claims abstract description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 7
- 239000008272 agar Substances 0.000 claims abstract description 7
- 239000008273 gelatin Substances 0.000 claims abstract description 7
- 229920000159 gelatin Polymers 0.000 claims abstract description 7
- 235000019322 gelatine Nutrition 0.000 claims abstract description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 7
- 235000013773 glyceryl triacetate Nutrition 0.000 claims abstract description 7
- 229960002622 triacetin Drugs 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- -1 polyoxyethylene Polymers 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims description 14
- 230000006378 damage Effects 0.000 abstract description 7
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 2
- 230000000968 intestinal effect Effects 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a pharmaceutical capsule material. The pharmaceutical capsule material comprises the following components: gelatin, glycerin triacetate, hydroxypropyl methyl cellulose (HPMC), acetic acid, polyoxyethylene, agar, glycerinum, water and ethylene glycol. The capsule prepared by the pharmaceutical capsule material can be easily absorbed by intestinal tracts, is high in dissolubility, and is capable of effectively reducing injuries to the intestinal tracts of patents.
Description
Technical field
The present invention relates to the technical field of medicinal materials, the more particularly to technical field of capsule for medicine material.
Background technology
Some drugs need to be taken by patient in forms such as powder, molecules, are to solve it to take difficulty, capsule for medicine
Thus produce.In capsule for medicine can be sealed in powder or granular medicament, by patient swallow in the form of entirety, thereafter in intestinal
Digested absorption in road, although this absorpting form avoids the stimulation of drugs on patients's stomach and damages, but while increased
The load of Intestinal Mucosal Injury in Patients Undergoing and the stimulation to Intestinal Mucosal Injury in Patients Undergoing.
The content of the invention
It is an object of the invention to propose a kind of capsule for medicine material that can effectively reduce the stimulation to Intestinal Mucosal Injury in Patients Undergoing.
Technical scheme is as follows：
A kind of capsule for medicine material, including following components：Gelatin, glycerol triacetate, hydroxypropyl methyl cellulose
(HPMC), acetic acid, Polyethylene oxide, agar, glycerol, water, ethylene glycol.
Preferably：In parts by mass, including following components：10~20 parts of gelatin, 0.1~0.5 part of glycerol triacetate,
1~2 part of hydroxypropyl methyl cellulose (HPMC), 0.05~0.1 part of acetic acid, 3~5 parts of Polyethylene oxide, 5~10 parts of agar, glycerol 5
~7 parts, 10~15 parts of water, 5~10 parts of ethylene glycol.
It is also preferred that：The polyoxyethylated molecular weight is 3000~8000.
Obtained capsule of the invention is beneficial to intestinal absorption, and dissolubility is good, can effectively reduce the damage to Intestinal Mucosal Injury in Patients Undergoing.
Specific embodiment
Embodiment 1
A kind of capsule for medicine material, in parts by mass, including following components：10 parts of gelatin, 0.1 part of glycerol triacetate,
1 part of hydroxypropyl methyl cellulose (HPMC), 0.05 part of acetic acid, 3 parts of Polyethylene oxide, 5 parts of agar, 5 parts of glycerol, 10 parts of water, second two
5 parts of alcohol, wherein the polyoxyethylated molecular weight is 3000.
Embodiment 2
A kind of capsule for medicine material, in parts by mass, including following components：20 parts of gelatin, 0.5 part of glycerol triacetate,
2 parts of hydroxypropyl methyl cellulose (HPMC), 0.1 part of acetic acid, 5 parts of Polyethylene oxide, 10 parts of agar, 7 parts of glycerol, 15 parts of water, second two
10 parts of alcohol, wherein the polyoxyethylated molecular weight is 8000.
Claims (3)
1. a kind of capsule for medicine material, it is characterised in that：Including following components：Gelatin, glycerol triacetate, hydroxypropyl methyl is fine
Dimension is plain (HPMC), acetic acid, Polyethylene oxide, agar, glycerol, water, ethylene glycol.
2. capsule for medicine material according to claim 1, it is characterised in that：In parts by mass, including following components：Gelatin
10~20 parts, 0.1~0.5 part of glycerol triacetate, 1~2 part of hydroxypropyl methyl cellulose (HPMC), 0.05~0.1 part of acetic acid,
3~5 parts of Polyethylene oxide, 5~10 parts of agar, 5~7 parts of glycerol, 10~15 parts of water, 5~10 parts of ethylene glycol.
3. capsule for medicine material according to claim 1, it is characterised in that：The polyoxyethylated molecular weight be 3000~
8000。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611072983.5A CN106667950A (en) | 2016-11-29 | 2016-11-29 | Pharmaceutical capsule material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611072983.5A CN106667950A (en) | 2016-11-29 | 2016-11-29 | Pharmaceutical capsule material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106667950A true CN106667950A (en) | 2017-05-17 |
Family
ID=58866901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611072983.5A Pending CN106667950A (en) | 2016-11-29 | 2016-11-29 | Pharmaceutical capsule material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106667950A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565411A (en) * | 2003-06-30 | 2005-01-19 | 高俊起 | A kind of manufacture method of medicinal hollow capsule shell |
| CN102688218A (en) * | 2012-05-24 | 2012-09-26 | 潍坊海之源生物制品有限公司 | Chitosan capsule shell and preparation method thereof |
| CN103260741A (en) * | 2010-10-26 | 2013-08-21 | 比利时胶囊公司 | Bulk enteric capsule shells |
| CN103520727A (en) * | 2012-08-06 | 2014-01-22 | 济南圣泉唐和唐生物科技有限公司 | Capsule shell and preparation method thereof |
| CN104940163A (en) * | 2015-06-24 | 2015-09-30 | 陈威宇 | Capsule shell |
-
2016
- 2016-11-29 CN CN201611072983.5A patent/CN106667950A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565411A (en) * | 2003-06-30 | 2005-01-19 | 高俊起 | A kind of manufacture method of medicinal hollow capsule shell |
| CN103260741A (en) * | 2010-10-26 | 2013-08-21 | 比利时胶囊公司 | Bulk enteric capsule shells |
| CN102688218A (en) * | 2012-05-24 | 2012-09-26 | 潍坊海之源生物制品有限公司 | Chitosan capsule shell and preparation method thereof |
| CN103520727A (en) * | 2012-08-06 | 2014-01-22 | 济南圣泉唐和唐生物科技有限公司 | Capsule shell and preparation method thereof |
| CN104940163A (en) * | 2015-06-24 | 2015-09-30 | 陈威宇 | Capsule shell |
Non-Patent Citations (1)
| Title |
|---|
| 王沛主编: "《药物制剂设备》", 31 January 2016, 中国医药科技出版社 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170517 |
|
| RJ01 | Rejection of invention patent application after publication |