CN106667949A - Capsule material - Google Patents
Capsule material Download PDFInfo
- Publication number
- CN106667949A CN106667949A CN201611071994.1A CN201611071994A CN106667949A CN 106667949 A CN106667949 A CN 106667949A CN 201611071994 A CN201611071994 A CN 201611071994A CN 106667949 A CN106667949 A CN 106667949A
- Authority
- CN
- China
- Prior art keywords
- parts
- glycerine
- capsule
- gelatin
- following components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 16
- 239000000463 material Substances 0.000 title claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 29
- 235000011187 glycerol Nutrition 0.000 claims abstract description 14
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 14
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 14
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 14
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 14
- 108010010803 Gelatin Proteins 0.000 claims abstract description 10
- 239000008273 gelatin Substances 0.000 claims abstract description 10
- 229920000159 gelatin Polymers 0.000 claims abstract description 10
- 235000019322 gelatine Nutrition 0.000 claims abstract description 10
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229920001817 Agar Polymers 0.000 claims abstract description 9
- 239000008272 agar Substances 0.000 claims abstract description 9
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims abstract 8
- 235000013773 glyceryl triacetate Nutrition 0.000 claims abstract 4
- 229960002622 triacetin Drugs 0.000 claims abstract 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 9
- 239000010977 jade Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 abstract description 6
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229940014259 gelatin Drugs 0.000 abstract 1
- 239000001587 sorbitan monostearate Substances 0.000 abstract 1
- 235000011076 sorbitan monostearate Nutrition 0.000 abstract 1
- 229940035048 sorbitan monostearate Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 7
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- -1 glycerine triacetic acid Ester Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a capsule material which comprises the following components: gelatin, sorbitan monostearate, glycerol triacetate, hydroxypropyl methyl cellulose (HPMC), agar, glycerol and water. The material disclosed by the invention is mild in performance, is lower in hardness after being formed into a capsule and easy to absorb, and can effectively reduce the damage to an intestinal tract of a patient.
Description
Technical field
The present invention relates to the technical field of medicinal materials, the more particularly to technical field of capsule for medicine material.
Background technology
Some drugs are needed to be taken by patient in forms such as powder, molecules, and difficulty, capsule for medicine are taken to solve it
Thus produce.In can be sealed in for powder or granular medicament by capsule for medicine, by patient swallow in the form of entirety, thereafter in intestines
Absorption is digested in road, although this absorpting form avoids the stimulation of drugs on patients's stomach and damages, but increased simultaneously
The load of Intestinal Mucosal Injury in Patients Undergoing and the stimulation to Intestinal Mucosal Injury in Patients Undergoing.
The content of the invention
It is an object of the invention to propose a kind of capsule for medicine material that can effectively reduce to the stimulation of Intestinal Mucosal Injury in Patients Undergoing.
Technical scheme is as follows：
A kind of capsule material, it is characterised in that：Including following components：Gelatin, sorbitan monoesters, glycerine triacetic acid
Ester, hydroxypropyl methyl cellulose (HPMC), agar, glycerine, water.
Preferably：In parts by mass, including following components：10~30 parts of gelatin, 1~3 part of sorbitan monoesters are sweet
0.1~0.5 part of oily triacetate, 1~1.5 part of hydroxypropyl methyl cellulose, 5~20 parts of agar, 5~7 parts of glycerine, water 7~10
Part.
It is also preferred that：In parts by mass, including following components：25 parts of gelatin, 1 part of sorbitan monoesters, glycerine
0.5 part of triacetate, 1 part of hydroxypropyl methyl cellulose, 15 parts of agar, 6 parts of glycerine, 8 parts of water.
Material property of the invention is gentle, and hardness is relatively low after being shaped to capsule, it is easy to absorb, and can effectively reduce to patient's intestines
The damage in road.
Specific embodiment
Embodiment 1
A kind of capsule material, in parts by mass, including following components：10 parts of gelatin, 1 part of sorbitan monoesters, glycerine
0.1 part of triacetate, 1 part of hydroxypropyl methyl cellulose (HPMC), 5 parts of agar, 5 parts of glycerine, 7 parts of water.
Embodiment 2
A kind of capsule material, in parts by mass, including following components：30 parts of gelatin, 3 parts of sorbitan monoesters, glycerine
0.5 part of triacetate, 1.5 parts of hydroxypropyl methyl cellulose, 20 parts of agar, 7 parts of glycerine, 10 parts of water.
Embodiment 3
A kind of capsule material, in parts by mass, including following components：25 parts of gelatin, 1 part of sorbitan monoesters, glycerine
0.5 part of triacetate, 1 part of hydroxypropyl methyl cellulose, 15 parts of agar, 6 parts of glycerine, 8 parts of water.
Claims (3)
1. a kind of capsule material, it is characterised in that：Including following components：Gelatin, sorbitan monoesters, glycerol triacetate,
Hydroxypropyl methyl cellulose (HPMC), agar, glycerine, water.
2. capsule material according to claim 1, it is characterised in that：In parts by mass, including following components：Gelatin 10~
30 parts, 1~3 part of sorbitan monoesters, 0.1~0.5 part of glycerol triacetate, 1~1.5 part of hydroxypropyl methyl cellulose, fine jade
5~20 parts of fat, 5~7 parts of glycerine, 7~10 parts of water.
3. capsule material according to claim 2, it is characterised in that：In parts by mass, including following components：Gelatin 25
Part, 1 part of sorbitan monoesters, 0.5 part of glycerol triacetate, 1 part of hydroxypropyl methyl cellulose, 15 parts of agar, 6 parts of glycerine,
8 parts of water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611071994.1A CN106667949A (en) | 2016-11-29 | 2016-11-29 | Capsule material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611071994.1A CN106667949A (en) | 2016-11-29 | 2016-11-29 | Capsule material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106667949A true CN106667949A (en) | 2017-05-17 |
Family
ID=58866904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611071994.1A Pending CN106667949A (en) | 2016-11-29 | 2016-11-29 | Capsule material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106667949A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552212A (en) * | 2012-03-01 | 2012-07-11 | 济南康和医药科技有限公司 | Soft capsule for improving cranial nerve function and preparation method thereof |
| CN103260741A (en) * | 2010-10-26 | 2013-08-21 | 比利时胶囊公司 | Bulk enteric capsule shells |
| CN104072811A (en) * | 2014-06-27 | 2014-10-01 | 浙江神能光降解材料有限公司 | Method for preparing hard capsule shells from plant-derived modified starch |
| CN104940163A (en) * | 2015-06-24 | 2015-09-30 | 陈威宇 | Capsule shell |
-
2016
- 2016-11-29 CN CN201611071994.1A patent/CN106667949A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103260741A (en) * | 2010-10-26 | 2013-08-21 | 比利时胶囊公司 | Bulk enteric capsule shells |
| CN102552212A (en) * | 2012-03-01 | 2012-07-11 | 济南康和医药科技有限公司 | Soft capsule for improving cranial nerve function and preparation method thereof |
| CN104072811A (en) * | 2014-06-27 | 2014-10-01 | 浙江神能光降解材料有限公司 | Method for preparing hard capsule shells from plant-derived modified starch |
| CN104940163A (en) * | 2015-06-24 | 2015-09-30 | 陈威宇 | Capsule shell |
Non-Patent Citations (1)
| Title |
|---|
| 王沛主编: "《药物制剂设备》", 31 January 2016, 中国医药科技出版社 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |