CN106580939A - Chlorhexidine gluconate disinfectant - Google Patents
Chlorhexidine gluconate disinfectant Download PDFInfo
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- CN106580939A CN106580939A CN201611160969.0A CN201611160969A CN106580939A CN 106580939 A CN106580939 A CN 106580939A CN 201611160969 A CN201611160969 A CN 201611160969A CN 106580939 A CN106580939 A CN 106580939A
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- Prior art keywords
- chlorhexidine gluconate
- final concentration
- disinfectant solution
- medical
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- 229960003333 chlorhexidine gluconate Drugs 0.000 title claims abstract description 64
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 title claims abstract description 64
- 239000000645 desinfectant Substances 0.000 title claims abstract description 53
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 16
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 16
- GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical compound CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000013019 agitation Methods 0.000 claims description 27
- 238000002360 preparation method Methods 0.000 claims description 18
- 239000004745 nonwoven fabric Substances 0.000 claims description 14
- 239000012567 medical material Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 238000009455 aseptic packaging Methods 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 238000005554 pickling Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 238000002386 leaching Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 42
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 3
- 230000007815 allergy Effects 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 3
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 8
- 230000002147 killing effect Effects 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 231100000111 LD50 Toxicity 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- RBMGJIZCEWRQES-DKWTVANSSA-N (2s)-2,4-diamino-4-oxobutanoic acid;hydrate Chemical compound O.OC(=O)[C@@H](N)CC(N)=O RBMGJIZCEWRQES-DKWTVANSSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a chlorhexidine gluconate disinfectant. The chlorhexidine gluconate disinfectant is prepared from a chlorhexidine gluconate solution, propylene glycol and polyethylene glycol nonylphenyl ether, or a chlorhexidine gluconate solution, propylene glycol polyethylene glycol nonylphenyl ether and ethyl alcohol. The chlorhexidine gluconate disinfectant is high in stability, resistant to high temperature, wide in spectrum, long-acting, free of irritating smell, safe, free of toxins and free of human body allergies, can be widely applied to hospitals, hotels, the service industry, public places, homes and the like, and has good market prospects.
Description
Technical field
The invention belongs to medicine and hygiene fieldses, be related to chlorhexidine gluconate disinfectant solution and its be prepared from it is medical wet
A kind of towel, and in particular to chlorhexidine gluconate sterilized for pre-surgical skin disinfection and cleaning wound and guard against cross infection
Disinfectant solution and its medical wet tissue being prepared from.
Background technology
Chlorhexidine gluconate medicinal liquid is colourless aqueous solution, and odorlessness, bitter in the mouth are stable in properties, shelf-stable, bactericidal effect
It is good, stimulate low, anaphylactic reaction seldom occur.Meanwhile, chlorhexidine gluconate is disinfection preservative, and its bacteriostasis and sterilization effect is wide
And it is strong, it is stronger than the antibacterial action of negative bacterium to gram positive bacteria, it is better than quaternary cationic surfactant bactericidal effect,
It is also effective to funguses.In the presence of having serum, blood still effectively, it is nonirritant to organizing, it is mainly used in skin degerming.
Chlorhexidine gluconate disinfectant solution currently used in the market, single varieties, specific aim be not strong, disinfection effect
Fruit is limited, it is difficult to meets existing diversification composite disinfecting sterilization and requires.Meanwhile, prepare degree of accuracy and cannot be guaranteed, and product
In pathogenic bacteria and microorganism effectively cannot control.Very big potential safety hazard is brought to patient or end user.With society
Development, the raising of people's health care consciousness, the also more and more higher of the requirement to sterile products.
The content of the invention
In order to solve problems of the prior art, an object of the present invention is that a kind of glucose pickling of offer must
The chlorhexidine gluconate disinfectant solution of the present invention is named as art Aminoplasmal Hepa-10 by safe disinfectant solution.The disinfectant solution stability is high, high temperature resistant,
Wide spectrum, long-acting, non-stimulated nature and flavor, safety non-toxic, human body is without allergy.
The second object of the present invention is to provide a kind of medical wet tissue, gluconic acid of the medical wet tissue comprising the present invention
Hibitane disinfectant solution.
To achieve these goals, present invention employs following technical scheme：
The invention provides a kind of chlorhexidine gluconate disinfectant solution, the chlorhexidine gluconate disinfectant solution includes following
Component：Final concentration of 2% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495%
Polyethylene glycol nonylphenyl ether, final concentration of 30% ethanol.
The invention provides a kind of chlorhexidine gluconate disinfectant solution, the chlorhexidine gluconate disinfectant solution includes group
Point：Final concentration of 4% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495% it is poly-
Ethylene glycol nonylplenyl ether.
Present invention also offers the preparation method of foregoing chlorhexidine gluconate disinfectant solution, the preparation method bag
Include following steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 2% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(4) 75% ethanol is weighed, squeezes into Agitation Tank, ethanol final concentration of 30%；
(5) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
Or,
The preparation method comprises the steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 4% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(5) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
Present invention also offers a kind of medical material, the medical material disappears comprising foregoing chlorhexidine gluconate
Venom.
Further, the medical material includes that medical wet tissue, medical immersion swab stick, medical immersion dressing, medical disinfecting are wiped
Piece.
Further, the medical material is in process of production all through sterilization treatment, so as to fully ensure that the safety of product
Property and stability, can be used directly after these product independent packagings and dress of unpacking, it is to avoid the cross-contamination of intermediate link and
Infection.
Further, the material of the medical wet tissue is non-woven fabrics.
Further, the size of the non-woven fabrics is 18.0cm × 18.0cm, and the weight of the non-woven fabrics is 180g.
The invention provides a kind of preparation method of foregoing medical wet tissue, the preparation method includes following step
Suddenly：
Foregoing chlorhexidine gluconate disinfectant solution is uniformly sprayed onto into non-woven fabrics up to saturation, you can be prepared from
The medical wet tissue of the present invention.
Further, the preparation method of foregoing medical wet tissue comprises the steps：
(1) non-woven fabrics of the size for 18.0cm × 18.0cm are prepared, weight is 180g；
(2) every block of non-woven fabrics are uniformly sprayed to saturation with the foregoing chlorhexidine gluconate disinfectant solution of 500mg, obtain
Medical wet tissue；
(3) the medical wet tissue aseptic packaging that step (2) is obtained.
The advantages of the present invention：
Chlorhexidine gluconate disinfectant solution stability prepared by the present invention is high, high temperature resistant, wide spectrum, long-acting, non-stimulated nature and flavor,
Safety non-toxic, human body can be widely used in hospital, hotel, service occupation, public place, family etc., with good without allergy
Market prospect.
Specific embodiment
With reference to embodiment, the present invention is further detailed explanation.Following examples be merely to illustrate the present invention and
It is not used in restriction the scope of the present invention.
The preparation of 1 chlorhexidine gluconate disinfectant solution of embodiment
As a example by preparing 100 kilograms of disinfectant solution
Concretely comprise the following steps：
(1) 10 kilogram of 20% chlorhexidine gluconate is weighed, squeezes into Agitation Tank；
(2) 10 kilogram of 99% Propylene Glycol is weighed, squeezes into Agitation Tank；
(3) 0.5 kilogram of 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank；
(4) 40 kilogram of 75% ethanol is weighed, squeezes into Agitation Tank；
(5) 39.5 kilograms of pure water are weighed, squeezes into Agitation Tank；
(6) stir 5 minutes, into chlorhexidine gluconate disinfectant solution.
The preparation of 2 chlorhexidine gluconate disinfectant solution of embodiment
As a example by preparing 100 kilograms of disinfectant solution
Concretely comprise the following steps：
(1) 20 kilogram of 20% chlorhexidine gluconate is weighed, squeezes into Agitation Tank；
(2) 10 kilogram of 99% Propylene Glycol is weighed, squeezes into Agitation Tank；
(3) 0.5 kilogram of 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank；
(4) 69.5 kilograms of pure water are weighed, squeezes into Agitation Tank；
(6) stir 5 minutes, into chlorhexidine gluconate disinfectant solution.
The Oral toxicity test of 3 chlorhexidine gluconate disinfectant solution of embodiment
Method：Take white mice body weight 15-20 gram 30 (male and female half and half), by body weight by dosage for 6g/Kg disinfectant solution from
Observation seven days is administered, as a result without death.Median lethal dose(LD 50) of the chlorhexidine gluconate disinfectant solution of the present invention to white mice
(LD50) more than 6g/Kg, as a result show：The chlorhexidine gluconate disinfectant solution of the present invention belongs to nontoxic level.
The irritation test of 4 chlorhexidine gluconate disinfectant solution of embodiment
Rabbit four is taken, the hair of back spinal column both sides is respectively cut into 3*3cm, take the chlorhexidine gluconate sterilization of the present invention
Liquid 0.5ml, drops on four layers of gauze of 2.5*2.5cm sizes, and gauze is spread on side skin, and opposite side applies drop normal saline
Gauze compare, then gauze is fixed with adhesive plaster and binder, apply four hours after, wash away left drug with warm water, as a result see
Examine 1,24,48,72 it is little smear position dermoreaction, occur without erythema and edema, as a result show：The glucose pickling of the present invention must
Safe disinfectant solution is to no skin irritation.
The bactericidal effect of 5 chlorhexidine gluconate disinfectant solution of embodiment
Method：By the chlorhexidine gluconate disinfectant solution of the present invention according to version in 2002《Disinfection technology standard》Related rule
Surely its killing action to microorganism is studied, is as a result shown：Disinfectant solution acts on 0.5min, to colibacillary average killing logarithm
Value>5.00, the average killing logarithm value to staphylococcus aureuses>5.00, the average killing logarithm value to Candida albicans>
4.00, the average killing logarithm value to Pseudomonas aeruginosa>5.00.As a result show：The chlorhexidine gluconate sterilization of the present invention
Liquid has efficient sterilization.
The stability of 6 chlorhexidine gluconate disinfectant solution of embodiment
In 37 DEG C ± 2 DEG C of temperature, place 12 months under conditions of relative humidity 75% ± 5%, the gluconic acid of the present invention
Every quality index of hibitane disinfectant solution is without significant change.As a result show：The chlorhexidine gluconate disinfectant solution tool of the present invention
There is good stability.
The preparation of 7 sterilizing wet tissue of embodiment
(1) non-woven fabrics of the size for 18.0cm × 18.0cm are prepared, weight is 180g；
(2) every block of non-woven fabrics are uniformly sprayed to saturation with the chlorhexidine gluconate disinfectant solution of the 500mg present invention, are cured
Use wet tissue；
(3) the medical wet tissue aseptic packaging that step (2) is obtained.
100 kilograms of chlorhexidine gluconate disinfectant solution prepared by embodiment 1 or embodiment 2 can be used for 200,000 pieces of preparation and kill
The medical wet tissue of bacterium sterilization.
The explanation of above-described embodiment is only intended to understand the method for the present invention and its core concept.It should be pointed out that for this
For the those of ordinary skill in field, under the premise without departing from the principles of the invention, some improvement can also be carried out to the present invention
And modification, these improve and modification will be also fallen in the protection domain of the claims in the present invention.
Claims (10)
1. a kind of chlorhexidine gluconate disinfectant solution, it is characterised in that the chlorhexidine gluconate disinfectant solution includes component：Eventually
Concentration be 4% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495% Polyethylene Glycol
Nonylplenyl ether.
2. a kind of chlorhexidine gluconate disinfectant solution, it is characterised in that the chlorhexidine gluconate disinfectant solution is included with the following group
Point：Final concentration of 2% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495% it is poly-
Ethylene glycol nonylplenyl ether, final concentration of 30% ethanol.
3. the preparation method of the chlorhexidine gluconate disinfectant solution described in claim 1, it is characterised in that the preparation method bag
Include following steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 4% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(4) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
4. the preparation method of the chlorhexidine gluconate disinfectant solution described in claim 2, it is characterised in that the preparation method bag
Include following steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 2% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(4) 75% ethanol is weighed, squeezes into Agitation Tank, ethanol final concentration of 30%；
(5) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
5. a kind of medical material, it is characterised in that the medical material must comprising the glucose pickling described in claim 1 or 2
Safe disinfectant solution.
6. medical material according to claim 5, it is characterised in that the medical material includes medical wet tissue, medical leaching
Liquid swab stick, medical immersion dressing, medical disinfecting pad.
7. the medical wet tissue described in claim 6, it is characterised in that the material of the wet tissue is non-woven fabrics.
8. the medical wet tissue described in claim 7, it is characterised in that the size of the non-woven fabrics is 18.0cm × 18.0cm, institute
The weight for stating non-woven fabrics is 180g.
9. the preparation method of the medical wet tissue any one of claim 5-8, it is characterised in that the preparation method includes
Following steps：
Chlorhexidine gluconate disinfectant solution described in claim 1 or 2 is uniformly sprayed onto into non-woven fabrics up to saturation, you can prepare
Form the medical wet tissue of the present invention.
10. preparation method according to claim 9, it is characterised in that the preparation method comprises the steps：
(1) non-woven fabrics of the size for 18.0cm × 18.0cm are prepared, weight is 180g；
(2) every block of non-woven fabrics are uniformly sprayed to saturation with the chlorhexidine gluconate disinfectant solution described in 500mg claim 1 or 2,
Obtain medical wet tissue；
(3) the medical wet tissue aseptic packaging that step (2) is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611160969.0A CN106580939A (en) | 2016-12-15 | 2016-12-15 | Chlorhexidine gluconate disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611160969.0A CN106580939A (en) | 2016-12-15 | 2016-12-15 | Chlorhexidine gluconate disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580939A true CN106580939A (en) | 2017-04-26 |
Family
ID=58801589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611160969.0A Pending CN106580939A (en) | 2016-12-15 | 2016-12-15 | Chlorhexidine gluconate disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106580939A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164107A (en) * | 1991-04-25 | 1992-11-17 | Becton, Dickinson And Company | Chlorhexidine composition useful in a surgical scrub |
| CN1391809A (en) * | 2002-08-12 | 2003-01-22 | 杨生 | Skin sterilizing agent before operation |
| CN104338121A (en) * | 2013-07-31 | 2015-02-11 | 青岛艾华隆生物科技有限公司 | Medical safe sterilization disinfectant |
-
2016
- 2016-12-15 CN CN201611160969.0A patent/CN106580939A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164107A (en) * | 1991-04-25 | 1992-11-17 | Becton, Dickinson And Company | Chlorhexidine composition useful in a surgical scrub |
| CN1391809A (en) * | 2002-08-12 | 2003-01-22 | 杨生 | Skin sterilizing agent before operation |
| CN104338121A (en) * | 2013-07-31 | 2015-02-11 | 青岛艾华隆生物科技有限公司 | Medical safe sterilization disinfectant |
Non-Patent Citations (4)
| Title |
|---|
| 中国轻工业集团生活用纸技术中心: "《中国生活用纸年鉴 2006-2007》", 31 January 2006, 中国石化出版社 * |
| 张余善: "《英汉日用化学工业词汇》", 31 May 1990, 轻工业出版社 * |
| 戴彦榛: "消毒药物的合理选择与应用", 《中国热带医学》 * |
| 陈海燕 等: "《静脉血管通路护理实践指南》", 30 April 2016, 复旦大学出版社 * |
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