CN101766186A - Composition capable of slowly-releasing chlorine dioxide and application thereof - Google Patents
Composition capable of slowly-releasing chlorine dioxide and application thereof Download PDFInfo
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- CN101766186A CN101766186A CN201010034403A CN201010034403A CN101766186A CN 101766186 A CN101766186 A CN 101766186A CN 201010034403 A CN201010034403 A CN 201010034403A CN 201010034403 A CN201010034403 A CN 201010034403A CN 101766186 A CN101766186 A CN 101766186A
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- CN
- China
- Prior art keywords
- chlorine dioxide
- composition
- acid
- wet tissue
- slowly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 title claims abstract description 138
- 239000004155 Chlorine dioxide Substances 0.000 title claims abstract description 69
- 235000019398 chlorine dioxide Nutrition 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 38
- 150000007524 organic acids Chemical class 0.000 claims abstract description 17
- 239000006174 pH buffer Substances 0.000 claims abstract description 6
- 239000007853 buffer solution Substances 0.000 claims abstract description 4
- 230000001954 sterilising effect Effects 0.000 claims description 45
- 239000011159 matrix material Substances 0.000 claims description 18
- 239000000645 desinfectant Substances 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 230000000844 anti-bacterial effect Effects 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 235000013599 spices Nutrition 0.000 claims description 7
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
- 229910001919 chlorite Inorganic materials 0.000 claims description 6
- 229910052619 chlorite group Inorganic materials 0.000 claims description 6
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 5
- 229960003260 chlorhexidine Drugs 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- -1 polyhexamethylene hydrochloric acid Polymers 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 229940123208 Biguanide Drugs 0.000 claims description 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 150000004283 biguanides Chemical class 0.000 claims description 4
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- 230000003588 decontaminative effect Effects 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
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- 235000014655 lactic acid Nutrition 0.000 claims description 3
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- 229940075582 sorbic acid Drugs 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims description 2
- 229940092714 benzenesulfonic acid Drugs 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229960003344 climbazole Drugs 0.000 claims description 2
- 239000000174 gluconic acid Substances 0.000 claims description 2
- 235000012208 gluconic acid Nutrition 0.000 claims description 2
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims description 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 235000006408 oxalic acid Nutrition 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 2
- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 229960003500 triclosan Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 14
- 238000006243 chemical reaction Methods 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract 2
- 239000006179 pH buffering agent Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 17
- 239000000654 additive Substances 0.000 description 10
- 238000009928 pasteurization Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 241000700605 Viruses Species 0.000 description 8
- 230000002147 killing effect Effects 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 230000000249 desinfective effect Effects 0.000 description 7
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- 238000012360 testing method Methods 0.000 description 6
- 230000000996 additive effect Effects 0.000 description 5
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- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 4
- 229960002218 sodium chlorite Drugs 0.000 description 4
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- 239000003213 antiperspirant Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000003559 chemosterilizing effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 239000003206 sterilizing agent Substances 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
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- 206010040880 Skin irritation Diseases 0.000 description 2
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- 229940095731 candida albicans Drugs 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
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- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
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- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
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- 230000002588 toxic effect Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- UPLPHRJJTCUQAY-WIRWPRASSA-N 2,3-thioepoxy madol Chemical compound C([C@@H]1CC2)[C@@H]3S[C@@H]3C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 UPLPHRJJTCUQAY-WIRWPRASSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
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- 241000193830 Bacillus <bacterium> Species 0.000 description 1
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- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
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- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
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- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
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- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
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Images
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a composition capable of slowly-releasing chlorine dioxide, which contains parent substances of chlorine dioxide, organic acid and conjugate base thereof, or organic acid and pH buffering agent to form a stable buffer system for keeping pH of the composition being 5-8. Meanwhile, the invention discloses disinfection wet wipes prepared from the composition. The invention is characterized in that the concentration of apparent chlorine dioxide of the composition is stably maintained in a low range by adjusting the mixture ratio of parent substances of chlorine dioxide and organic acid in different pH buffer systems according to a chemical reaction equilibrium principle, thereby realizing the same disinfection effect and avoiding using complex slowly-releasing systems for chlorine dioxide.
Description
Technical field
The present invention relates to a kind of composition, but particularly relate to a kind of composition and the application in the sterilizing product thereof of slowly-releasing chlorine dioxide.
Background technology
Chlorine dioxide be generally acknowledge at present a kind of efficient, low toxicity, fast, wide spectrum the 4th generation the disinfecting disinfectant, classified as A1 level disinfectant with extremely strong sterilizing power, characteristic not carcinogenic, non-secondary pollution by The World Health Organization (WHO).As present optimal a kind of chemosterilant, chlorine dioxide has replaced aldehydes, phenols, quaternary ammonium disinfectant, by extensive use in the world.Through Environmental Protection Agency (EPA) and food and drug administration (FDA) approval, be used for sterilization, sterilization, deodorizing and industry, agricultural and the health care of food fresh keeping, processing, drinking water.Because of it has 100% sterilizing rate to bacterium, fungi, virus, gemma, be widely used in medical disinfecting abroad, especially in the field, oral cavity to the sterilization of sterilization, deodorizing and environment of gargling of sterilization, mildew-resistant, the oral cavity of medical material apparatus, but also do not apply in China.Under the chlorine dioxide normal temperature yellow green gas, good water solubility, but unstable volatilization easily can only be preserved very difficult long term storage 8 hours under the normal temperature.Most disinfection agent of chlorine dioxide product all is chlorine dioxide precursor in fact on the market, must now do existing usefulness through overactivation.
Infection by diseases such as SARS and Influenza A H1N1s is popular, and people's habits and customs and life idea have been subjected to very big impact, and increasing people has accepted and brought into use sterile products.Yet the action time of traditional disinfectant is short, and effect is undesirable, chafe, and toxic and side effect is big, easily contaminated environment.Can't satisfy at traditional sterile products under the situation of increasingly serious safe and sanitary demand, be that the green sterile products of representative is just beginning to come into gradually people's the visual field with the chlorine dioxide, and probably derive a new industry one green sterilization industry thereupon.
Pasteurization towelette in the market is a feast for the eyes, we have carried out efficiency analysis and contrast at the bigger famous brand name of several market shares, find that Jue Daduoshuo pasteurization towelette all is to be main disinfection composition with guanidine class disinfectant (polyhexamethylene hydrochloric acid biguanides, Chlorhexidine) on the market.Though these two kinds of disinfectant good stabilities, easy compatibility, cost is low, and the efficient of sterilization is very low, can only reach 90%, and is also undesirable to the killing effect of virus, and this class disinfectant has cumulative toxic and side effect, and be not suitable for frequent use.
" disinfection technology standard " that China Ministry of Public Health formulated carried out clearly classification to the sterilization ability of disinfection factor: " low-level sterilization: can only kill vegetative forms of bacteria and the chemosterilant of lipophilic virus and the mechanical sterilization's methods such as gas, flushing of loosing of ventilating.As metal ion disinfectants such as strand quaternary ammonium disinfectant (benzalkonium bromide etc.), biguanides disinfectant such as Chlorhexidine, Chinese herbal disinfectant and mercury, silver, copper etc., with suitable concentration and effective function time method of disinfecting "; " high level disinfection method: the sterilization method that can kill all pathogenic microorganisms.This class disinfectant should be able to be killed all bacterial propagules (comprising Much's bacillus), virus, fungi and spore thereof and bacterial spore (except the bacterial spore of some high drags).The chemosterilant and the physical sterilization that belong to this type of have: methyl hydantoin compounds such as ultraviolet ray and generally chloride, chlorine dioxide, Peracetic acid, hydrogen peroxide, bromine-containing disinfectant, ozone, C5H6Br2N2O2 and disinfectant that some are composite etc. are under defined terms, with proper dosage or concentration and effective function time method of disinfecting." this shows that disinfected paper napkin in the market all belongs to low-level sterilization, can't satisfy the hygienic requirements and the market demand of control virus disseminating at all.At current H1N1, in the moment that viruses such as hepatitis B are wreaked havoc, market more needs green safety as chlorine dioxide, the high level disinfection agent of high-efficiency broad spectrum.
Summary of the invention
The purpose of this invention is to provide a kind of slowly composition of stable releasing chlorine dioxide, with and application in the sterilizing product.
For achieving the above object, but technical scheme of the present invention provides a kind of composition of slowly-releasing chlorine dioxide, comprises chlorine dioxide matrix, also comprise organic acid and its conjugate base, or organic acid and pH buffer, forming stable buffer system, the pH that keeps composition is 5-8.The present invention utilizes the chemical reaction equilibrium principle, (wherein pH is low more with the proportioning of organic acid under different pH buffer systems (pH5-8) by chlorine dioxide matrix in the adjustment composition, the chlorine dioxide matrix consumption is big more), the concentration of the apparent chlorine dioxide of composition can stably be maintained in the 0.01-200ppm scope.Preferably maintain 0.01ppm-10ppm, 10-30ppm is in three scopes of 30-50ppm.Zoopery shows, the concentration of chlorine dioxide is also without any side effects when 200ppm, still is not that the concentration of chlorine dioxide is high more good more, because, chlorine dioxide concentration promptly can reach 99.99% sterilizing rate at 0.1-10ppm, can be higher to the killing rate of virus.And the excessive concentration of chlorine dioxide has dense penetrating odor, is unfavorable for the application of chlorine dioxide.Our experiment shows: the chlorine dioxide matrix of low concentration exists chemical reaction equilibrium with organic acid under different pH values, consumption by adjusting chlorine dioxide matrix and with the organic acid proportioning, can make the maintaining in the lower scope of concentration stabilize of chlorine dioxide, so both reach the effect of same sterilizing, avoided using complicated chlorine dioxide slow-release system again.
Composition of the present invention, wherein said chlorine dioxide matrix are stable ClO 2 solution or chlorite.When being stable ClO 2 solution, its consumption is decided according to its concentration, and the concentration of open market upward stability ClO 2 solution is 2%-8%, and then the consumption of stable ClO 2 solution is 10-80 weight % in this composition; When being chlorite, its consumption is generally 0.1-10 weight %, decides according to the required bactericidal effect of product.
Composition of the present invention, wherein said organic acid comprises one or more in citric acid, phosphoric acid, tartaric acid, acetate, benzene sulfonic acid, oxalic acid, malic acid, benzoic acid, salicylic acid, lactic acid, gluconic acid, sorbic acid, the glycolic acid.It has the organic acid that the present invention uses and the chlorine dioxide matrix reaction on the one hand, and the effect of slowly-releasing chlorine dioxide (promptly as exciting agent) also forms the pH that buffer system is come the control combination thing with its conjugate base or pH buffer simultaneously jointly.
Composition of the present invention, wherein said pH value buffer are to make system pH maintain buffer or the combinations of buffers of 5.0-8.0, as boric acid-Boratex, and potassium dihydrogen phosphate and/or sodium hydrogen phosphate, acetate-sodium acetate etc.
Composition of the present invention, the consumption of wherein said chlorine dioxide matrix is as the criterion at 0.01-200ppm with the apparent chlorine dioxide concentration of keeping composition.
Composition of the present invention also comprises other sterilizing composition, forms the composite bactericidal disinfectant with chlorine dioxide matrix; Other sterilizing composition comprises one or more in polyhexamethylene hydrochloric acid biguanides, Chlorhexidine, trichlorine kappa, triclosan, climbazole, glycolylurea, two imidazolidinyl urea, the quaternary ammonium salt.
Composition of the present invention can slowly discharge chlorine dioxide in long-time, it can be widely used in the product that preparation has the sterilizing effect.As pasteurization towelette, medical mask or the like.
Further, but the invention provides a kind of wet tissue of slowly-releasing chlorine dioxide, comprise the wet tissue carrier, on described carrier, contain the above-mentioned composition of the present invention.
On described carrier, can also contain irreducibility spices and/or preserve moisture composition and/or surfactant; Perhaps nutrition, curative effect-type skin care additive and/or other special purpose additives.Described irreducibility spices be not with the natural perfume material or the synthetic spices of chlorine dioxide reaction.The described composition of preserving moisture comprises: propane diols, glycerine, butanediol, polyethylene glycol, sorbierite, hyaluronic acid, pyrrolidone sodium carboxylate, hydrolysis ossein and other commercially available composition of preserving moisture.Described nutrition, curative effect-type skin care additive comprise animals and plants extract, animals and plants active ingredient, physiological activator, trace element and hormone.Described other special purpose additives comprises sun-screening agent, astringent, antiperspirant, deodorant, antiphlogistic, antipruritic, detergent.
Described carrier is nonwoven, woven or paper handkerchief.Described nonwoven is a spunlace non-woven cloth, and preferred thickness is 30g-80g/m
2, cotton content is the straight shop of 20-80% or tiltedly spreads nonwoven.Described woven is a kind of in the towelling of 20-80% of cotton or cotton content.
Wet tissue can be applicable in the cleaning, decontamination, sterilization, sterilization of article.Wherein, to the cleaning of article, decontamination, the sterilization and sterilization including, but not limited to mobile phone, keyboard, mouse, refrigerator, dining table, kitchen tools, tableware, micro-wave oven, article such as glasses; To the cleaning of fruit, sterilization, sterilization mainly is at the fruit exocuticle; Be used for skin and mainly comprise hand, face, the cleaning at positions such as foot, sterilization, sterilization; What be used for skin also comprises makeup removing, clean the moon, and it is smelly to dispel; The lavatory with and be used for virus or bacterial dermopathic sterilization, sterilization.
Wet tissue provided by the invention preferably adopts by following method and makes:
One, high-effective disinfecting wet tissue (chlorine dioxide apparent concentration 30-50ppm):
(1) prepares wet tissue carrier: 60cm
2-600cm
2
(2) preparation mixed liquor:
Chlorine dioxide matrix is (if use chlorite, 1.0-10 weight %; If with the stable ClO 2 solution of 2-8%, 20-80 weight %);
Organic acid: 0.01-10 weight %;
Irreducibility spices: 0-5 weight %;
The composition of preserving moisture: 0-10 weight %;
Skin care additive: 0-10 weight %;
Other special purpose additives: 0-10 weight %;
Surfactant: 0-10 weight %;
Other sterilizing composition: 0-2 weight %;
pH＝5.0-7.0；
Or regulate pH=5.0-7.0 with suitable pH value buffer;
All the other are water.
(3) above-mentioned mixed liquor is sprayed on the wet tissue carrier every gram wet tissue carrier 2-6mL.
Two, middle effect pasteurization towelette (chlorine dioxide apparent concentration 10-30ppm):
(1) prepares wet tissue carrier: 60cm
2-600cm
2
(2) preparation mixed liquor:
Chlorine dioxide matrix is (if use chlorite, 0.5-1.0 weight %; If with the stable ClO 2 solution of 2-8%, 20-40 weight %);
Organic acid: 0.01-10 weight %;
Irreducibility spices: 0-5 weight %;
The composition of preserving moisture: 0-10 weight %;
Skin care additive: 0-10 weight %;
Other special purpose additives: 0-10 weight %;
Surfactant: 0-10 weight %;
Other sterilizing composition: 0-2 weight %;
Regulate pH=5.5-7.0 with suitable pH value buffer;
All the other are water.
(3) above-mentioned mixed liquor is sprayed on the wet tissue carrier every gram wet tissue carrier 2-6mL.
Three, poor efficiency pasteurization towelette (chlorine dioxide apparent concentration 0.01-10ppm):
(1) prepares wet tissue carrier: 60cm
2-600cm
2
(2) preparation mixed liquor:
Chlorine dioxide matrix is (if use chlorite, 0.01-0.6 weight %; If with the stable ClO 2 solution of 2-8%, 10-30 weight %);
Organic acid: 0.01-10 weight %;
Irreducibility spices: 0-5 weight %;
The composition of preserving moisture: 0-10 weight %;
Skin care additive: 0-10 weight %;
Other special purpose additives: 0-10 weight %;
Surfactant: 0-10 weight %;
Other sterilizing composition: 0-2 weight %;
Regulate pH=6.5-8.0 with suitable pH value buffer;
All the other are water.
(3) above-mentioned mixed liquor is sprayed on the wet tissue carrier every gram wet tissue carrier 2-6mL.
Technical scheme of the present invention has following technique effect:
But 1, provide a kind of composition of slowly-releasing chlorine dioxide, utilize the chemical reaction equilibrium principle, by adjusting chlorine dioxide matrix and the proportioning of organic acid under different pH buffer systems, make the maintaining in the lower scope of concentration stabilize of the apparent chlorine dioxide of composition, so both reach the effect of same sterilizing, avoided using complicated chlorine dioxide slow-release system again.
2, it is unstable in product to adopt simple technological means to solve chlorine dioxide, or needs the difficult problem of complicated stable and release tech means when using in product, has enlarged the production application scope of product.
3, reduced the consumption of chlorine dioxide matrix significantly, effectively prevented in the production process chlorine corrosion equipment.
4, the prescription that contains the chlorine dioxide wet tissue in three variable concentrations intervals is provided, has satisfied the requirement of different crowd Disinfection Effect.
Description of drawings
Fig. 1 is the stability test figure as a result of the embodiment of the invention 1;
Fig. 2 is the stability test figure as a result of the embodiment of the invention 2;
Fig. 3 is the stability test figure as a result of the embodiment of the invention 3.
Embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
The present invention prepares wet tissue according to following steps:
1. form according to the prescription of product, each component is mixed, stir, make mixed liquor;
2. by product purpose standard cutting wet tissue carrier;
3. above-mentioned mixed liquor is sprayed on the wet tissue carrier, every gram wet tissue carrier 2-6mL, the wet tissue carrier after moistening is the functional wipes that contains chlorine dioxide.
4. the monolithic wet tissue is sealed with plastic packaging bag and be finished product.
Embodiment 1: the high-effective disinfecting wet tissue (chlorine dioxide apparent concentration 30-50ppm) that is used for the kitchen wherein mixed liquor composition is:
1), stable ClO 2 solution (concentration 2%) (meets standard GB/T20783-2006): 80%
2), citric acid: 0.44%
3), sodium citrate: 8.21%
4)，pH＝6.0，
5), propane diols: 4%
6), neopelex: 5%
7), APG decontamination factor: 2%
All the other are water.
Embodiment 2: the effect pasteurization towelette (chlorine dioxide apparent concentration 10-30ppm) that is used for skin clean
Wherein the mixed liquor composition is:
1), sodium chlorite: 0.7%
2), lactic acid: 0.94%
3), sodium hydrogen phosphate: 7.50%
4)，pH＝5.5，
5), hyaluronic acid: 2%
6), nucleic acid extractive: 2%
All the other are water.
Embodiment 3: be used for poor efficiency pasteurization towelette (chlorine dioxide apparent concentration 0.01-10ppm) sun-proof, antiperspirant
Wherein the mixed liquor composition is:
1), sodium chlorite: 0.5%
2), sorbic acid: 0.16%
3), potassium sorbate: 8.60%
4)，pH＝6.5，
5), glycerine: 4%
6), p-aminobenzoic acid (sun-screening agent): 1.5%
7), aluminum sulfate (antiperspirant) is an amount of
All the other are water.
Embodiment 4: the composite disinfecting wet sanitary napkins
Wherein the mixed liquor composition is:
1), sodium chlorite: 0.3%
2), acetate: 0.5%
3), sodium acetate: 1.2%
4)，pH＝6.5，
5), trichlorine kappa: 0.5%
All the other are water.
Embodiment 5: skin care antiseptic hygiene wet tissue
1), sodium chlorite: 0.3%
2), citric acid: 1.5%
3), sodium citrate: 2.2%
4)，pH＝7.0，
5), glycerine: 4%
6), flavoring rose essence: 2%
7), propolis: 8%
8), Chlorhexidine: 1%
All the other are water.
The performance evaluation of wet tissue
According to the disposable use amenities of National Standard sanitary standard " stability, validity and the safety that contains the functional wipes of chlorine dioxide provided by the invention estimated.
A, estimation of stability
According to the GB requirement, the bactericidal effect of wet sanitary napkins will keep more than 1 year, can adopt 54 ℃ to quicken experiment sample is carried out estimation of stability, be about to ready-made wet tissue packing and finish and place in the baking oven that is placed on 54 ℃, sampling every day detects active ingredient chlorine dioxide wherein.The wet tissue of embodiment 1-3 is done above-mentioned test, the results are shown in Figure 1, Fig. 2, Fig. 3.
Testing result shows that the concentration range of the effective chlorine dioxide of sample is stable, and product stability meets the GB requirement, and the bactericidal property of product does not have tangible change in 1 year shelf life.
B, the bactericidal effect evaluation
" disinfection technology standard " to the wet tissue series products require as follows: wet tissue must not detect pathogenic bacteria, wet sanitary napkins will be more than 90% to staphylococcus aureus and colibacillary killing rate, has the effect then should be more than 90% to the oidiomycetic killing rate of white if show to fungi.And we are in order to show the superiority of chlorine dioxide wet sanitary napkins, and the embodiment 3 minimum to chlorine dioxide content carried out the detection of bactericidal property.Here 7 kinds of common pathogenic bacteria are detected, and sterilizing time only is 90 seconds (GB examination criteria the shortest is 2 minutes, and only requires two kinds of bacteriums are detected).
To the summary of germ and kill the result such as following table (embodiment 3):
| Microorganism | The disease that may cause | Killing rate (90 seconds) | Kill logarithm value |
| Escherichia coli | Enteritis, diarrhoea, urethritis, cystitis, pyelonephritis, peritonitis, appendicitis, septicemia | ??＞99.999 | ??＞6.11 |
| Staphylococcus aureus | Diarrhoea, chordapsus, vomiting, heating | ??＞99.999 | ??＞6.3 |
| Pseudomonas aeruginosa | Purulent lesion | ??＞99.999 | ??＞6.11 |
| Microorganism | The disease that may cause | Killing rate (90 seconds) | Kill logarithm value |
| Candida albicans | Thrush, vaginitis | ??＞99.999 | ??＞5.63 |
| Friedlander | Tracheitis, pneumonia, meningitis, Urinary system inflammation, wound pathology | ??＞99.999 | ??＞6.32 |
| Staphylococcus albus | Vomiting, diarrhoea | ??＞99.999 | ??＞6.06 |
| Aspergillus niger | Grain goes mouldy | ??96.111 | ??1.40 |
See by testing result, the bactericidal effect of product has satisfied the requirement of GB for the hand sterilization, has " sterilization " effect, and the sterilizing time of this detection will lack 25% than the minimum requirements time in the GB (2 minutes), only have 90 seconds action time, can not only kill staphylococcus aureus, Escherichia coli and Candida albicans, can also kill pseudomonas aeruginosa, Friedlander and staphylococcus albus, aspergillus niger has also been played bactericidal effect.Be used as (GB requires 20min) when extending to 15min with the time, killing of above bacterial classification reached more than 5 number average, the killing rate to bacillus subtilis var can reach 99.98% in addition.
C, safety evaluatio
According to " disinfection technology standard " requirement, pasteurization towelette must carry out skin irritation test, and we entrust Beijing's associated mechanisms that the pasteurization towelette of embodiment one has been carried out the skin irritation human trial, and result of the test is as follows:
The human body patch test of pasteurization towelette (30 example)
The % that the present invention relates to all is weight percentage except that no specified otherwise.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. but the composition of a slowly-releasing chlorine dioxide comprises chlorine dioxide matrix, it is characterized in that, also comprises organic acid and its conjugate base, or organic acid and pH buffer, forms stable buffer system, and the pH that keeps composition is 5-8.
2. composition as claimed in claim 1 is characterized in that, described chlorine dioxide matrix is stable ClO 2 solution or chlorite.
3. composition as claimed in claim 1 or 2, it is characterized in that described organic acid comprises one or more in citric acid, phosphoric acid, tartaric acid, acetate, benzene sulfonic acid, oxalic acid, malic acid, benzoic acid, salicylic acid, lactic acid, gluconic acid, sorbic acid, the glycolic acid.
4. as each described composition of claim 1-3, it is characterized in that the consumption of described chlorine dioxide matrix is to keep the apparent chlorine dioxide concentration of composition at 0.01-200ppm.
5. as each described composition of claim 1-4, it is characterized in that, also comprise other sterilizing composition, form the composite bactericidal disinfectant with chlorine dioxide matrix; Other sterilizing composition comprises one or more in polyhexamethylene hydrochloric acid biguanides, chlorhexidine, trichlorine kappa, triclosan, climbazole, glycolylurea, two imidazolidinyl urea, the quaternary ammonium salt.
6. each described composition of claim 1-5 has application in the product of sterilizing effect in preparation.
7. but the wet tissue of a slowly-releasing chlorine dioxide comprises the wet tissue carrier, it is characterized in that, contains each described composition of claim 1-5 on described carrier.
8. wet tissue as claimed in claim 7 is characterized in that, also contains irreducibility spices and/or preserve moisture composition and/or surfactant on described carrier.
9. as claim 7 or 8 described wet tissues, it is characterized in that described carrier is nonwoven, woven or paper handkerchief.
10. the purposes of each described wet tissue of claim 7-9 in the cleaning of article, decontamination, sterilization, sterilization.
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| CN201010034403A CN101766186A (en) | 2010-01-15 | 2010-01-15 | Composition capable of slowly-releasing chlorine dioxide and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103417154A (en) * | 2013-07-26 | 2013-12-04 | 广州联庄科技有限公司 | Mobile-phone antibacterial cleaning wet tissue |
| CN104430311A (en) * | 2014-10-30 | 2015-03-25 | 北京海洁海斯健康科技有限公司 | Active bactericidal medicine as well as preparation method and special equipment thereof |
| DE102016007081A1 (en) * | 2016-06-10 | 2017-12-14 | Alethia Life Sciences Ag | Chlorine dioxide disinfection cloth |
| CN110692648A (en) * | 2019-09-09 | 2020-01-17 | 龙泽云 | A kind of manufacture method of high-concentration and high-stability monobasic chlorine dioxide aqueous solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103417154A (en) * | 2013-07-26 | 2013-12-04 | 广州联庄科技有限公司 | Mobile-phone antibacterial cleaning wet tissue |
| CN104430311A (en) * | 2014-10-30 | 2015-03-25 | 北京海洁海斯健康科技有限公司 | Active bactericidal medicine as well as preparation method and special equipment thereof |
| CN104430311B (en) * | 2014-10-30 | 2017-05-10 | 北京海洁海斯健康科技有限公司 | Active bactericidal medicine as well as preparation method and special equipment thereof |
| DE102016007081A1 (en) * | 2016-06-10 | 2017-12-14 | Alethia Life Sciences Ag | Chlorine dioxide disinfection cloth |
| CN110692648A (en) * | 2019-09-09 | 2020-01-17 | 龙泽云 | A kind of manufacture method of high-concentration and high-stability monobasic chlorine dioxide aqueous solution |
| CN111248221A (en) * | 2020-02-13 | 2020-06-09 | 上海克琴科技有限公司 | Long-acting disinfectant stabilized by synergist |
| CN111298178A (en) * | 2020-03-03 | 2020-06-19 | 江苏龙蟠科技股份有限公司 | Chlorine dioxide refrigerator bacteriostatic deodorant and preparation method thereof |
| CN115884679A (en) * | 2020-03-22 | 2023-03-31 | Csp技术公司 | Disinfection system and method using chlorine dioxide gas forming polymer composition |
| CN111621141A (en) * | 2020-06-12 | 2020-09-04 | 广西大学 | Slow-release chlorine dioxide-waterborne polyurethane antibacterial film and preparation method thereof |
| CN117920076A (en) * | 2024-02-23 | 2024-04-26 | 广东绿茉迪环保科技有限公司 | Gel for removing formaldehyde and preparation method thereof |
| CN117920076B (en) * | 2024-02-23 | 2024-06-28 | 广东绿茉迪环保科技有限公司 | Gel for removing formaldehyde and preparation method thereof |
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Application publication date: 20100707 |