CN106511735A - Snake gall bulbus fritilariae loquat paste and preparing method thereof - Google Patents
Snake gall bulbus fritilariae loquat paste and preparing method thereof Download PDFInfo
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- CN106511735A CN106511735A CN201611206777.9A CN201611206777A CN106511735A CN 106511735 A CN106511735 A CN 106511735A CN 201611206777 A CN201611206777 A CN 201611206777A CN 106511735 A CN106511735 A CN 106511735A
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- bulbus fritillariae
- fritillariae cirrhosae
- paste
- fel serpentis
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- 241000270295 Serpentes Species 0.000 title claims abstract description 18
- 235000009008 Eriobotrya japonica Nutrition 0.000 title abstract description 9
- 241001092070 Eriobotrya Species 0.000 title abstract 7
- 238000000034 method Methods 0.000 title description 3
- 239000003814 drug Substances 0.000 claims abstract description 15
- 235000013717 Houttuynia Nutrition 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims description 29
- 238000001914 filtration Methods 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 241000758769 Houttuynia Species 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 241000935235 Fritillaria meleagris Species 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 210000000941 bile Anatomy 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 6
- 238000007598 dipping method Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 2
- 238000002386 leaching Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 16
- 239000002994 raw material Substances 0.000 abstract description 4
- 241000758794 Asarum Species 0.000 abstract 2
- 240000000691 Houttuynia cordata Species 0.000 abstract 2
- 235000008216 herbs Nutrition 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 244000061508 Eriobotrya japonica Species 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 235000020995 raw meat Nutrition 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241001425800 Pipa Species 0.000 description 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 description 1
- 240000003582 Platycodon grandiflorus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses snake gall bulbus fritilariae loquat paste. The paste is prepared from, by weight, 5-8 parts of snake gall, 50-80 parts of bulbus fritilariae, 60-90 parts of loquat leaves and 5-10 parts of heartleaf houttuynia herbs. The selected raw materials of the snake gall bulbus fritilariae loquat paste are classic formula raw materials of traditional snake gall bulbus fritilariae loquat paste, the inherent curative effect of the snake gall bulbus fritilariae loquat paste in the prior art is kept, meanwhile, the improvement ingredient heartleaf houttuynia herbs of the proper quantity are added, the unexpected technical effect is achieved for improving the traditional snake gall bulbus fritilariae loquat paste, the outstanding promotion effect on the application effect of the paste is achieved, and the paste can be assimilated by the human body better, and has a remarkable promotion effect of improving the curative effect of medicine.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation composition, more particularly to a kind of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae and preparation method thereof, category
In the linguistic term of classical traditional Chinese medicine compound preparation.
Background technology
Snake gall, is the gall-bladder of storage courage sweat in snake body, ovalize or oval, and utricule is more straight, can be used as medicine.
Tendril-leaved fritillary bulb, is conventional Chinese medicine, and traditional effect is moistening lung, cough-relieving, resolving sputum, and in all age medication only takes its underground
Bulb.
Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae is classical relieving cough and asthma Chinese prescription, with good anti-inflammatory, cough-relieving, relievings asthma, dispels
Phlegm etc. is acted on, for the symptoms such as the coughing with a lot of sputum caused by the infection of the upper respiratory tract have good therapeutic action.
Traditional Chinese medicine compound preparation is prepared for the application of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, mainly traditional manual preparation way
, so in the preparation process of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, the medicine effect uniformity of the Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae of different batches compared with
Difference.Simultaneously because in preparation process, the restriction of different production environment is readily incorporated different pollution sources, causes shake bile-fritillary
The drug effect of loquat leaf extract is further affected.
Simultaneously as the paste viscosity of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae is larger, patient using corresponding pharmaceutical preparation when
Wait, absorb bad, bioavilability is not high, slow curative effect, gives people a kind of not good impression of drug effect.
The content of the invention
It is an object of the invention to overcome the application effect in prior art existing for Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae not good, drug effect
Play the deficiency of DeGrain, there is provided a kind of brand-new Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae improves formula and preparation method thereof.The present invention
Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae improve after, the preparation effect of medicine is more significantly, it is possible to increase classical Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae
Absorption rate so as to therapeutic effect is greatly improved.
In order to realize foregoing invention purpose, the invention provides technical scheme below：
A kind of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, including the following components of weight portion makes：
Snake bile 5-8 parts, tendril-leaved fritillary bulb 50-80 parts, loguat leaf 60-90 parts, cordate houttuynia 5-10 parts.
The raw material that the Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae of the present invention is selected is the classical formula material of traditional Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae,
The intrinsic curative effect of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae of the prior art is maintained, while appropriate improvement composition cordate houttuynia is added, it is right
There is unexpected technique effect in the Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae for improving traditional, dash forward very much for the application effect of paste has
The facilitation for going out.
Further, the following components of the Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, including weight portion is made：Snake bile 6-8 parts, tendril-leaved fritillary bulb
55-80 parts, loguat leaf 70-90 parts, cordate houttuynia 6-10 parts.
Further, the following components of the Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, including weight portion is made：Snake bile 7-8 parts, tendril-leaved fritillary bulb
60-70 parts, loguat leaf 70-85 parts, cordate houttuynia 6-7 parts.
The present invention additionally provides a kind of method for preparing above-mentioned Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae simultaneously, and specific technical scheme is such as
Under.
A kind of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae preparation method, comprises the following steps：
（1）It is prepared by Bulbus Fritillariae Cirrhosae fluidextract：Bulbus Fritillariae Cirrhosae 50-80g is taken, and grain diameter is crushed to less than 0.4mm, according to liquid extract and leaching
Percolation under paste item, uses 50%-70% ethanol as solvent, after dipping 2-5 days, slowly diacolation, and it is standby to collect liquid of just filtering, and continues
Diacolation, treats that soluble component is filtered out completely, and continuous liquid of filtering is concentrated in right amount, adds liquid of just filtering, mixing to continue to be concentrated into 50-80ml,
100-200 eye mesh screens are filtered.
（2）To criticize and leaf 60-90g and cordate houttuynia 5-10g will be mixed, plus the pure water of 1-3 times of weight will be decocted 3 times, the 1st 3-
5 hours, the 2nd 1-2 hour, third time 0.5-1 hour, collecting decoction, filtration, filtrate were concentrated into 1ml medicine companies correspondence 1g raw materials
Medicinal material.
（3）By sucrose 400g, the ethanol solution containing essence is added, boiling makes dissolving, lets cool, by prepared by step 1 oozing
Extract prepared by liquid and the step 2 of filtering is added thereto, and stirs, adds water to 1000ml, stir evenly, obtain final product Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae.
Further, step 1, is crushed to particle by 40-80 eye mesh screens, you can meet grain diameter wanting less than 0.4mm
Ask.
Further, step 3, after the constant volume that adds water, can add appropriate preservative as needed.
Compared with prior art, beneficial effects of the present invention：
1. the Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae of the present invention, is filled a prescription on the basis of existing classical ancient prescription Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae
Upgrading is improved, and the Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae after improvement has good Composition Control feature, preferably can be absorbed by human body,
For the curative effect for improving medicine has significant facilitation.
2. Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae preparation method is scientific and reasonable, high for the effective component extraction efficiency in medicine, can
Significantly improve medicine for the effect of the treatment infection of the upper respiratory tract.
Specific embodiment
With reference to test example and specific embodiment, the present invention is described in further detail.But this should not be understood
Scope for above-mentioned theme of the invention is only limitted to below example, and all technologies realized based on present invention belong to this
The scope of invention.In the present invention, not specified percentage is weight percentage, and what ethanol solution was not specified is body
Product percentage.
Embodiment 1
Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, is made up of the following components of weight portion：7 parts of snake bile, 65 parts of tendril-leaved fritillary bulb, 80 parts of loguat leaf, fish
5 parts of raw meat grass.
Embodiment 2
Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, is made up of the following components of weight portion：6 parts of snake bile, 72 parts of tendril-leaved fritillary bulb, 80 parts of loguat leaf, fish
7 parts of raw meat grass.
Embodiment 3
It is prepared by Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae
（1）It is prepared by Bulbus Fritillariae Cirrhosae fluidextract：Bulbus Fritillariae Cirrhosae 60g is taken, is crushed, cross 40 eye mesh screens, according under liquid extract and extract item
Percolation, uses 70v% ethanol as solvent, and dipping is after 3 days, slowly diacolation, and it is standby to collect liquid of just filtering, and continues diacolation, treat it is soluble into
Divide and filter out completely, continuous liquid of filtering is concentrated in right amount, add liquid of just filtering, mixing to continue to be concentrated into 60ml, 200 eye mesh screens are filtered.
（2）Batch leaf 80g and cordate houttuynia 8g will be mixed, plus the pure water decoction of 2 times of weight 3 times, the 1st time 3 hours, the 2nd
Secondary 2 hours, third time 1 hour, collecting decoction, filtration, filtrate concentration 88ml.
（3）By sucrose 400g, the ethanol solution containing essence is added, boiling makes dissolving, lets cool, by prepared by step 1 oozing
Extract prepared by liquid and the step 2 of filtering is added thereto, and stirs, adds water to 1000ml, stir evenly, obtain final product Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae.
Embodiment 4
It is prepared by Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae
（1）It is prepared by Bulbus Fritillariae Cirrhosae fluidextract：Bulbus Fritillariae Cirrhosae 75g is taken, is crushed, cross 60 eye mesh screens, according under liquid extract and extract item
Percolation, uses 60v% ethanol as solvent, and dipping is after 5 days, slowly diacolation, and it is standby to collect liquid of just filtering, and continues diacolation, treat it is soluble into
Divide and filter out completely, continuous liquid of filtering is concentrated in right amount, add liquid of just filtering, mixing to continue to be concentrated into 75ml, 100 eye mesh screens are filtered.
（2）Batch leaf 80g and cordate houttuynia 6g will be mixed, plus the pure water decoction of 2 times of weight 3 times, the 1st time 4 hours, the 2nd
Secondary 1.5 hours, third time 0.5 hour, collecting decoction, filtration, filtrate concentration 85ml.
（3）By sucrose 400g, the ethanol solution containing essence is added, boiling makes dissolving, lets cool, by prepared by step 1 oozing
Extract prepared by liquid and the step 2 of filtering is added thereto, and stirs, adds water to 1000ml, adds appropriate preservative, stir evenly, obtain final product snake
Courage CHUANBEI PIPA GAO.
Embodiment 5
It is prepared by Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae
（1）It is prepared by Bulbus Fritillariae Cirrhosae fluidextract：Bulbus Fritillariae Cirrhosae 50g is taken, and grain diameter is crushed to less than 0.4mm, according to liquid extract and medicinal extract
Percolation under agent item, uses 50v% ethanol as solvent, and dipping is after 2 days, slowly diacolation, and it is standby to collect the liquid 38ml that just filters, and continues to ooze
Filter, make soluble component filter out completely, continuous liquid of filtering is concentrated in right amount, add liquid of just filtering, mixing to continue to be concentrated into 50ml, 200 mesh
Screen cloth is filtered.
（2）To criticize and leaf 70g and cordate houttuynia 5g will be added water to cook 3 times, the 1st time 3 hours, the 2nd time 2 hours, the 3rd time 1 hour,
Collecting decoction, filtration, filtrate are concentrated into 75ml.
（3）Ethanol solution containing essence, adds sucrose 400g, and boiling makes dissolving, and filtration, filtrate are let cool, made with step 1
Aqueous extract mixing prepared by standby Bulbus Fritillariae Cirrhosae fluidextract and step 2, stirring add water to 1000ml, stir evenly, obtain final product shake bile-fritillary
Loquat leaf extract.
Embodiment 6
It is prepared by Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae
（1）It is prepared by Bulbus Fritillariae Cirrhosae fluidextract：Bulbus Fritillariae Cirrhosae 40g is taken, is crushed, cross 40 eye mesh screens, according under liquid extract and extract item
Percolation, uses 70% ethanol as solvent, and dipping is after 4 days, slowly diacolation, and it is standby to collect the liquid 41ml that just filters, and continues diacolation, makes solvable
Property composition filter out completely, continuous liquid of filtering is concentrated in right amount, adds liquid of just filtering, mixing, continues to be concentrated into 45ml, filtration.
（2）Balloonflower root is added water to cook leaf 2 times with criticizing, the 1st time 2.5 hours, the 2nd time 2 hours, collecting decoction, filtration were filtered
Liquid is concentrated in right amount.
（3）60v% ethanol solutions, add sucrose 400g and Preservative qs, and boiling makes dissolving, and filtration is let cool to room temperature,
Mix with Bulbus Fritillariae Cirrhosae fluidextract, add appropriate amount of essence, add the extraction with aqueous solution liquid of step 2, stirring to add water to 1000ml, stir
It is even, obtain final product Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae.
Claims (6)
1. a kind of following components of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, including weight portion is made：
Snake bile 5-8 parts, tendril-leaved fritillary bulb 50-80 parts, loguat leaf 60-90 parts, cordate houttuynia 5-10 parts.
2. Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae as claimed in claim 1, it is characterised in that make including the following components of weight portion：Snake gall
Juice 6-8 parts, tendril-leaved fritillary bulb 55-80 parts, loguat leaf 70-90 parts, cordate houttuynia 6-10 parts.
3. Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae as claimed in claim 1, it is characterised in that make including the following components of weight portion：Snake gall
Juice 7-8 parts, tendril-leaved fritillary bulb 60-70 parts, loguat leaf 70-85 parts, cordate houttuynia 6-7 parts.
4. a kind of Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae preparation method, comprises the following steps：
（1）It is prepared by Bulbus Fritillariae Cirrhosae fluidextract：Bulbus Fritillariae Cirrhosae 50-80g is taken, and grain diameter is crushed to less than 0.4mm, according to liquid extract and leaching
Percolation under paste item, uses 50%-70% ethanol as solvent, after dipping 2-5 days, slowly diacolation, and it is standby to collect liquid of just filtering, and continues
Diacolation, treats that soluble component is filtered out completely, and continuous liquid of filtering is concentrated in right amount, adds liquid of just filtering, mixing to continue to be concentrated into 50-80ml,
100-200 eye mesh screens are filtered；
（2）To criticize and leaf 60-90g and cordate houttuynia 5-10g will be mixed, plus the pure water of 1-3 times of weight will be decocted 3 times, the 1st time 3-5 will be little
When, the 2nd 1-2 hour, third time 0.5-1 hour, collecting decoction, filtration, filtrate are concentrated into 1ml medicine companies correspondence 1g bulk drugs
Material；
（3）By sucrose 400g, the ethanol solution containing essence is added, boiling makes dissolving, lets cool, percolate prepared by step 1
The extract prepared with step 2 is added thereto, and stirs, adds water to 1000ml, stir evenly, obtain final product Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae.
5. Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae preparation method as claimed in claim 1, it is characterised in that step 1, is crushed to particle and passes through
40-80 eye mesh screens, you can meet requirement of the grain diameter less than 0.4mm.
6. Extractum Fel Serpentis et Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae preparation method as claimed in claim 1, it is characterised in that step 3, after the constant volume that adds water, can
To add appropriate preservative as needed.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108057115A (en) * | 2018-02-08 | 2018-05-22 | 北京倍菲瑞德健康科技有限公司 | A kind of composition for treating inflammation of upper respiratory tract infection and preparation method thereof |
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2016
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108057115A (en) * | 2018-02-08 | 2018-05-22 | 北京倍菲瑞德健康科技有限公司 | A kind of composition for treating inflammation of upper respiratory tract infection and preparation method thereof |
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