CN106508930A - Sterilization composition containing benthiavalicarb-isopropyl and fludioxonil - Google Patents
Sterilization composition containing benthiavalicarb-isopropyl and fludioxonil Download PDFInfo
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- CN106508930A CN106508930A CN201510587288.1A CN201510587288A CN106508930A CN 106508930 A CN106508930 A CN 106508930A CN 201510587288 A CN201510587288 A CN 201510587288A CN 106508930 A CN106508930 A CN 106508930A
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- China
- Prior art keywords
- fludioxonil
- benzene metsulfovax
- composition containing
- bactericidal composition
- metsulfovax
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- 239000005781 Fludioxonil Substances 0.000 title claims abstract description 75
- 239000000203 mixture Substances 0.000 title claims abstract description 70
- MUJOIMFVNIBMKC-UHFFFAOYSA-N fludioxonil Chemical compound C=12OC(F)(F)OC2=CC=CC=1C1=CNC=C1C#N MUJOIMFVNIBMKC-UHFFFAOYSA-N 0.000 title claims abstract description 59
- USRKFGIXLGKMKU-ABAIWWIYSA-N benthiavalicarb-isopropyl Chemical compound C1=C(F)C=C2SC([C@@H](C)NC(=O)[C@H](C(C)C)NC(=O)OC(C)C)=NC2=C1 USRKFGIXLGKMKU-ABAIWWIYSA-N 0.000 title abstract description 7
- 230000001954 sterilising effect Effects 0.000 title abstract 8
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 8
- 239000003814 drug Substances 0.000 claims abstract description 15
- 208000031888 Mycoses Diseases 0.000 claims abstract description 11
- 229940079593 drug Drugs 0.000 claims abstract description 6
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 5
- 241000233614 Phytophthora Species 0.000 claims abstract description 5
- 241000233629 Phytophthora parasitica Species 0.000 claims abstract description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 189
- UDSJPFPDKCMYBD-UHFFFAOYSA-N Metsulfovax Chemical compound S1C(C)=NC(C)=C1C(=O)NC1=CC=CC=C1 UDSJPFPDKCMYBD-UHFFFAOYSA-N 0.000 claims description 47
- 230000000844 anti-bacterial effect Effects 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 241000894006 Bacteria Species 0.000 claims description 8
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 8
- 240000003768 Solanum lycopersicum Species 0.000 claims description 8
- 150000001412 amines Chemical class 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 8
- UGYRYNXDEOFIQB-UHFFFAOYSA-N benzene thiophene Chemical compound S1C=CC=C1.C1=CC=CC=C1.C1=CC=CC=C1 UGYRYNXDEOFIQB-UHFFFAOYSA-N 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 239000000375 suspending agent Substances 0.000 claims description 5
- 239000004563 wettable powder Substances 0.000 claims description 5
- 239000003905 agrochemical Substances 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000004530 micro-emulsion Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 230000002265 prevention Effects 0.000 abstract description 8
- 238000002360 preparation method Methods 0.000 abstract description 5
- 235000013339 cereals Nutrition 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 244000052769 pathogen Species 0.000 abstract description 2
- 230000001934 delay Effects 0.000 abstract 1
- 230000009044 synergistic interaction Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 21
- 238000000034 method Methods 0.000 description 15
- -1 diffusant Substances 0.000 description 11
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- 239000002994 raw material Substances 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 235000021317 phosphate Nutrition 0.000 description 6
- 229940051841 polyoxyethylene ether Drugs 0.000 description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 description 6
- 230000002195 synergetic effect Effects 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 241001272567 Hominoidea Species 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 241000123650 Botrytis cinerea Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 150000002190 fatty acyls Chemical group 0.000 description 2
- 235000012055 fruits and vegetables Nutrition 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 229910052622 kaolinite Inorganic materials 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229940068984 polyvinyl alcohol Drugs 0.000 description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 2
- 150000003233 pyrroles Chemical class 0.000 description 2
- QJBZDBLBQWFTPZ-UHFFFAOYSA-N pyrrolnitrin Chemical compound [O-][N+](=O)C1=C(Cl)C=CC=C1C1=CNC=C1Cl QJBZDBLBQWFTPZ-UHFFFAOYSA-N 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- KBRSJPHSCOAFDR-UHFFFAOYSA-N 3-chloro-6-methyl-5,5-dioxo-11h-benzo[c][2,1]benzothiazepin-11-ol Chemical compound O=S1(=O)N(C)C2=CC=CC=C2C(O)C2=CC=C(Cl)C=C21 KBRSJPHSCOAFDR-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000813090 Rhizoctonia solani Species 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- SMLHHBQGIJMAIM-UHFFFAOYSA-N calcium;2-dodecylbenzenesulfonic acid Chemical compound [Ca].CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O SMLHHBQGIJMAIM-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical compound FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 229960002132 pyrrolnitrin Drugs 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a sterilization composition containing benthiavalicarb-isopropyl and fludioxonil. The sterilization composition uses benthiavalicarb-isopropyl and fludioxonil as main active components, wherein a weight ratio of benthiavalicarb-isopropyl to fludioxonil is (1-70): (1-50). The invention also discloses application of the sterilization composition to preparation of drugs used for preventing and treating fungal diseases of resistant plants; and the sterilization composition is applicable to prevention and treatment of diseases attacking cereals, fruit trees and vegetable, has high synergistic interaction, overcomes and delays the resistance of pathogens and has the advantages of fast sterilization speed, long action period, reduced application cost and obviously better prevention and treatment effect compared with individual usage of benthiavalicarb-isopropyl and fludioxonil. The sterilization composition is applicable to prevention and treatment of fungal diseases attacking crops, especially to prevention and treatment of fungal diseases like phytophthora root rot, late blight, downy mildew, damping-off and gray mold; and the effect of the sterilization composition is better than the effect of individual benthiavalicarb-isopropyl or fludioxonil.
Description
Technical field
The present invention relates to a kind of bactericidal composition and application thereof, especially a kind of bactericidal composition containing benzene metsulfovax and fludioxonil and
Its application.
Background technology
Benzene metsulfovax (benthiavalicarb-isopropyl), molecular formula：C18H24FN3O3S, chemical name：[[(6- fluorobenzene is simultaneously
Thiazol-2-yl)-ethylaminocarbonyl] -2- methyl-propyls] carbamic acid isopropyl ester.
Benzene metsulfovax have good bactericidal activity to phytophthora root rot, to its sporangial formation, sporangial sprouting at low concentrations
There is good inhibiting effect, but the release to zoospore and the movement of zoospore are not acted on.In field test, benzene thiophene bacterium
Amine is with relatively low dosage (25～75g a.i./hm2) can effectively control late blight, grape and other crops of potato and tomato
Downy mildew.
Fludioxonil (Fludioxonil), molecular formula：C12H6F2N2O2, 4- (2,2- bis- fluoro- 1,3- benzos dioxy -4- bases) pyrroles's -3- nitriles,
Chemical structural formula：
Fludioxonil derives from natural products pyrrolnitrin, is new pyrrole class, non-internal-absorting, wide-spectrum bactericide.It is mainly used in
Wheat, barley, corn, pea, rape, paddy rice, ornamental crops, hard fruits and vegetables, grape and lawn etc., used as blade face
Bactericide is used for preventing and treating the rotten Fusariumsp of snow, wheat net raw meat black rot, rhizoctonia solani etc., has special efficacy to gray mold.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, with economy such as the change of pattern of farming, melon fruits and vegetables
Crops planting area progressively expands, and disease occurrence degree, generation quantity increase, and in preventing and treating, difficulty is increased；The opposing party
Face, the resistance of pathogen rise under lasting medicament selection pressure year by year, and the prevention effect of single dose is had a greatly reduced quality, plant disease
Preventing and treating is faced with significant challenge.
The content of the invention
The purpose of the present invention be for above-mentioned technical problem provide a kind of applied widely, low cost, effect it is good containing benzene metsulfovax
With the plant bactericidal composition of fludioxonil.
The purpose of the present invention is realized by following measures：
A kind of bactericidal composition containing benzene metsulfovax and fludioxonil, it with benzene metsulfovax and fludioxonil as main active, wherein
Benzene metsulfovax are 1～70 with the weight ratio of fludioxonil：1～50, wherein in bactericidal composition, effective ingredient is deposited with enhancing effective amount
In being composition.
In bactericidal composition of the present invention, the weight ratio preferably 5～50 of described benzene metsulfovax and fludioxonil：10～
50, more preferably 5～40：10～50, most preferably 1：1～10.
In bactericidal composition of the present invention, both described benzene metsulfovax and fludioxonil account for the weight percentage of composition
For 2～80%, preferably 5.5～70%.
Bactericidal composition of the present invention is with benzene metsulfovax and fludioxonil as principle active component, and known auxiliary agent and excipient
It is re-dubbed any one formulation allow on agricultural chemicals.Auxiliary agent, excipients known to these have dispersant, diffusant, defoamer,
Wetting agent, disintegrant etc., can be using to methoxyl group fatty acyl amido benzene sulfonic acid sodium salt, sodium methylene bis-naphthalene sulfonate, dodecyl
Benzene sulfonic acid calcium, APES, alkylaryl polyoxyethylene polyoxypropylene ether again, Ben-zylphenol Polyoxyethyl Ether, phenethyl
Phenol polyethenoxy ether, three phenethyl phenol polyoxyethylene ether phosphates, AEO and its similar products, fatty amine gather
Oxygen vinethene, fatty acid ethylene oxide addition product, polyoxyethylene polyoxypropylene block compound, castor oil polyoxyethylene ether, nonyl
Base phenol polyethenoxy ether, TWEEN Series, polyethylene glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphorous acid
One or more combinations in salt, lignosulfonates, xanthans, phenol formaldehyde condensate, ammonium salt, quaternary etc., figuration
Agent includes cyclohexanone, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as propane diols), deionized water etc..Above auxiliary agent,
Excipient and other auxiliary materials can be with alone or be used in combination.
Described formulation is missible oil, wettable powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
It is a still further object of the present invention to provide the bactericidal composition causes on fungal disease medicine in preparation preventing and treating resistance plant fungi
Application.Preferably, described bactericidal composition is preparing preventing and treating Cereal, fruit tree, vegetable crop refractory fungal disease medicine
The application of aspect, is especially preparing the fungal disease medicines such as preventing and treating phytophthora root rot, late blight, downy mildew, damping-off, gray mold
On application, most preferably prepare preventing and treating tomato gray mould medicine on application.Described bactericidal composition is to above-mentioned resistance plant
Fungal disease is respectively provided with significant effect, can produce higher synergistic function.
Compared with prior art, beneficial effects of the present invention：
(1), compared with single dose, the bactericidal composition scope of application of the present invention increases, and expands preventing and treating spectrum, it is adaptable to prevent and treat cereal
Class, fruit tree, the refractory fungal disease of vegetables, have preventing and treating effect well to sac fungus, basidiomycetes, Fungi Imperfecti fungal disease
Really, it is particularly suitable for preventing and treating phytophthora root rot, late blight, downy mildew, damping-off, gray mold, is respectively provided with significant effect, energy
Produce higher synergistic function.
(2), compared with single dose, overcome and delayed the resistance to the action of a drug, fungi can be suppressed (benzene metsulfovax and bacterium to be coughed up to unitary agent
Nitrile is arbitrary) drug-fast generation, alternative routine and be also easy to produce the agricultural chemicals of resistance.
(3), the consumption of the amount ratio independent reactive compound of bactericidal composition of the present invention is substantially reduced, i.e. the activity of mixture is big
In the activity of independent component, compared with single dose, preventing and treating recruitment, drug cost is reduced.
Specific embodiment
With reference to embodiments technical scheme is described further, two kinds of reactive compounds can be processed into permission
Any one formulation, but the preparation that can process of the two kinds of active components be not limited only to it is set forth below.The system of formulation in embodiment
Preparation Method is conventional method.
" % " of the present invention is weight percentage.
Embodiment 1
Weigh benzene metsulfovax 5g, fludioxonil 10g, detergent LS (to methoxyl group fatty acyl amido benzene sulfonic acid sodium salt) 2g, diffusion
Agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin add to 100g, and mixture carries out air-flow crushing, system
It is 15% benzene metsulfovax-fludioxonil wettable powder to obtain active ingredient weight percentage.
Embodiment 2
Weigh benzene metsulfovax 3g, fludioxonil 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite
Soil adds to 100g, and mixture carries out air-flow crushing, and it is 15% benzene metsulfovax-fludioxonil that active ingredient weight percentage is obtained
Wettable powder.
Embodiment 3
Weigh benzene metsulfovax 2g, fludioxonil 14g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite
Soil adds to 100g, and mixture carries out air-flow crushing, and it is 16% benzene metsulfovax-fludioxonil that active ingredient weight percentage is obtained
Wettable powder.
Embodiment 4
Weigh benzene metsulfovax 5g, fludioxonil 50g, three phenethyl phenol polyoxyethylene ether phosphate 3g, agriculture breast 33# (alkyl virtue
Base polyoxyethylene polyoxypropylene ether) 2g, APES 1g, 100# solvent naphtha 13g, add water to 100g.Will be with
Upper raw material routinely prepares the method input mixing kettle high speed mixing of aqueous emulsion, makes effective Ingredients Weight percentage composition for 55%
Benzene metsulfovax-fludioxonil aqueous emulsion.
Embodiment 5
Weigh benzene metsulfovax 2g, fludioxonil 30g, calcium dodecyl benzene sulfonate 6g, three phenethyl phenol polyoxyethylene ether phosphates
3g, agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely matched somebody with somebody
Mix in the method input mixing kettle of microemulsion processed, it is that 32% benzene metsulfovax-fludioxonil is micro- to make effective Ingredients Weight percentage composition
Emulsion.
Embodiment 6
Weigh benzene metsulfovax 1g, fludioxonil 5g, three phenethyl phenol polyoxyethylene ether phosphate 3g, agriculture breast 33#2g, alkyl phenol
APEO 1g, 100# solvent naphtha 13g, adds water to 100g.Above raw material is routinely prepared into the method input of aqueous emulsion
Mixing kettle high speed mixes, and makes effective Ingredients Weight percentage composition for 6% benzene metsulfovax-fludioxonil aqueous emulsion.
Embodiment 7
Weigh benzene metsulfovax 50g, fludioxonil 20g, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor-oil plant
Oily APEO 2g, plus 100# solvent naphthas are to 100g.Above raw material is routinely prepared in the method input mixing kettle of missible oil
Mixing, makes effective Ingredients Weight percentage composition for 70% benzene metsulfovax-fludioxonil missible oil.
Embodiment 8
Benzene metsulfovax 2g, fludioxonil 40g, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g is weighed, plus
100# solvent naphthas are to 100g.Mix in the method input mixing kettle that above raw material is routinely prepared missible oil, make active ingredient
Weight percentage is 42% benzene metsulfovax-fludioxonil missible oil.
Embodiment 9
Weigh benzene metsulfovax 5g, fludioxonil 20g, calcium dodecyl benzene sulfonate 6g, three phenethyl phenol polyoxyethylene ether phosphates
3g, agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely matched somebody with somebody
Mix in the method input mixing kettle of microemulsion processed, it is that 25% benzene metsulfovax-fludioxonil is micro- to make effective Ingredients Weight percentage composition
Emulsion.
Embodiment 10
Benzene metsulfovax 5g, fludioxonil 0.5g, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g is weighed, plus
100# solvent naphthas are to 100g.Mix in the method input mixing kettle that above raw material is routinely prepared missible oil, make active ingredient
Weight percentage is 5.5% benzene metsulfovax-fludioxonil missible oil.
Embodiment 11
Benzene metsulfovax 5g, fludioxonil 30g, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g is weighed, plus
100# solvent naphthas are to 100g.Mix in the method input mixing kettle that above raw material is routinely prepared missible oil, make active ingredient
Weight percentage is 35% benzene metsulfovax-fludioxonil missible oil.
Embodiment 12
Weigh benzene metsulfovax 10g, fludioxonil 10g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g,
Ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, make in the presence of sand mill effectively into
Weight percentage is divided to be 20% benzene metsulfovax-fludioxonil suspending agent.
Embodiment 13
Weigh benzene metsulfovax 30g, fludioxonil 12g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g,
Ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, make in the presence of sand mill effectively into
Weight percentage is divided to be 42% benzene metsulfovax-fludioxonil suspending agent.
Embodiment 14
Weigh benzene metsulfovax 2g, fludioxonil 5g, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, poly-
Vinyl alcohol 5g, borax 2g, white carbon 3g, diatomite complement to 100g, and above raw material is made by water dispersible granular agent method
Active ingredient weight percentage is 7% benzene metsulfovax-fludioxonil water dispersion granule.
Embodiment 15
Weigh benzene metsulfovax 4g, fludioxonil 13g, it is sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, poly-
Vinyl alcohol 5g, borax 2g, diatomite complement to 100g, and above raw material is formed with imitating composition by water dispersible granular agent method
Weight percentage is 17% benzene metsulfovax-fludioxonil water dispersion granule.
Embodiment 16
Weigh benzene metsulfovax 5g, fludioxonil 15g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, second
Glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, make active ingredient in the presence of sand mill
Weight percentage is 20% benzene metsulfovax-fludioxonil suspending agent.
Embodiment 17
Indoor biometricses are tested：
Mycelial growth rate method is adopted indoors, determines different agents to graw mold of tomato bacterial strain (Botrytis cinerea
Pers. EC)50Value, using co-toxicity coefficient computational methods, calculates the co-toxicity coefficient (CTC) of mixture, determines mixture
Building performance, circular is as follows：
With in mixture, a certain single dose (generally selects EC as standard agent50Junior), calculated：
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Toxicity index × the B of the toxicity index of theoretical toxicity index=A single doses × A single doses proportion+B single doses in mixture is mono-
Agent proportion in mixture
The EC of actual measurement toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：When CTC is more than 120, mixture has synergetic, and CTC exists for antagonism, CTC when being less than 80
It is summation action between 80-120.
Table 1：Indoor biometricses result of the benzene metsulfovax+fludioxonil different ratio to graw mold of tomato bacterial strain
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| Benzene metsulfovax (A) | Y=1.45X+3.90 | 5.698 | - |
| Fludioxonil (B) | Y=2.31X+2.69 | 10.021 | - |
| A:B=80:1 | Y=3.52X+1.73 | 8.484 | 118.75 |
| A:B=1:1 | Y=1.57X+3.66 | 7.160 | 178.46 |
| A:B=1:3 | Y=2.63X+2.73 | 7.294 | 203.10 |
| A:B=1:6 | Y=2.42X+3.07 | 6.255 | 254.19 |
| A:B=1:10 | Y=2.18X+2.99 | 8.324 | 198.07 |
| A:B=1:60 | Y=1.24X+3.48 | 16.666 | 104.45 |
| A:B=1:70 | Y=2.03X+2.61 | 15.080 | 115.63 |
1 indoor biometricses of table test result indicate that, benzene metsulfovax and fludioxonil weight ratio are 1～70：1～50 composition is malicious altogether
Coefficient is both greater than 120, has obvious synergistic function to botrytis cinerea.
Field control effectiveness test：
Carried out preventing and treating graw mold of tomato test with pesticidal preparations obtained in above-described embodiment.
1st, test process：This test medicine consumption sets three concentration for the treatment of, comparison medicament point respectively according to the difference of each composition
It is not 10% benzene metsulfovax EW of agricultural chemicals single dose and 50% fludioxonil WP and blank clean water experiment.
2nd, test method：Each plot area is 66.7m2, it is repeated 3 times；Investigation drug effect side after investigating and prevent and treat before dispenser
Method is：5 points of the grab sample in the test process area (takes 5m per2), the state of an illness is carried out according to national field test relevant criterion
Classification, calculates preventive effect.
3rd, result of the test see the table below：
Table 2：Field efficacy result of the benzene metsulfovax+fludioxonil different ratio to graw mold of tomato
As shown in Table 2：Compared with single dose, benzene metsulfovax and fludioxonil composition have significant effect, energy to graw mold of tomato
Produce higher synergistic function.The consumption of the amount ratio independent reactive compound of bactericidal composition is substantially reduced, i.e. mixture
Activity more than independent component activity, compared with single dose, reduce preventing and treating recruitment, drug cost.
Shown by indoor biometricses and field efficacy result, benzene metsulfovax there is obvious Synergistic to make with fludioxonil composition
With the prevention effect of composition is excellent, and prevention effect is better than single dose kind, in agricultural application has using value.
Claims (10)
1. a kind of bactericidal composition containing benzene metsulfovax and fludioxonil, it is characterised in that it is main with benzene metsulfovax and fludioxonil
Active component, described benzene metsulfovax are 1～70 with the weight ratio of fludioxonil：1～50.
2. the bactericidal composition containing benzene metsulfovax and fludioxonil according to claim 1, it is characterised in that described benzene thiophene
Bacterium amine is 5～50 with the weight ratio of fludioxonil：10～50.
3. the bactericidal composition containing benzene metsulfovax and fludioxonil according to claim 2, it is characterised in that described benzene thiophene
The weight ratio of bacterium amine and fludioxonil is 5～40：10～50.
4. the bactericidal composition containing benzene metsulfovax and fludioxonil according to claim 3, it is characterised in that described benzene thiophene
The weight ratio of bacterium amine and fludioxonil is 1：1～10.
5. the bactericidal composition containing benzene metsulfovax and fludioxonil according to claim 1, it is characterised in that described benzene thiophene
It is 2～80% that both bacterium amine and fludioxonil account for the weight percentage of composition.
6. the bactericidal composition containing benzene metsulfovax and fludioxonil according to claim 5, it is characterised in that described benzene thiophene
It is 5.5～70% that both bacterium amine and fludioxonil account for the weight percentage of composition.
7. the bactericidal composition containing benzene metsulfovax and fludioxonil according to claim 1, it is characterised in that it is with benzene thiophene bacterium
Amine and fludioxonil are that principle active component and insecticides adjuvant, excipients are configured to any one formulation allow on agricultural chemicals.
8. the bactericidal composition containing benzene metsulfovax and fludioxonil according to claim 7, it is characterised in that described formulation
It is missible oil, suspending agent, aqueous emulsion, wettable powder, microemulsion or water dispersion granule.
9. the bactericidal composition containing benzene metsulfovax and fludioxonil described in claim 1 is preparing preventing and treating resistance plant fungal disease
Application on medicine.
10. the bactericidal composition containing benzene metsulfovax and fludioxonil described in claim 1 prepare preventing and treating phytophthora root rot, late blight,
Application on the fungal disease germ killing drugs such as downy mildew, damping-off, gray mold, preferably on preventing and treating tomato gray mould medicine is prepared
Application.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09183703A (en) * | 1995-12-28 | 1997-07-15 | Kumiai Chem Ind Co Ltd | Agricultural and horticultural fungicide composition |
| CN1067060C (en) * | 1994-08-03 | 2001-06-13 | 久美蓝化学工业株式会社 | Amino acid derivative, process for producing same, agrohorticultural fungicide, and fungicidal method |
| CN1409596A (en) * | 1999-12-13 | 2003-04-09 | 拜尔公司 | Fungicidal combinations of active substances |
-
2015
- 2015-09-15 CN CN201510587288.1A patent/CN106508930A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067060C (en) * | 1994-08-03 | 2001-06-13 | 久美蓝化学工业株式会社 | Amino acid derivative, process for producing same, agrohorticultural fungicide, and fungicidal method |
| JPH09183703A (en) * | 1995-12-28 | 1997-07-15 | Kumiai Chem Ind Co Ltd | Agricultural and horticultural fungicide composition |
| CN1409596A (en) * | 1999-12-13 | 2003-04-09 | 拜尔公司 | Fungicidal combinations of active substances |
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