CN106466309A - A kind of radiation-induced skin ulcer nursing emulsifiable paste and preparation method thereof - Google Patents
A kind of radiation-induced skin ulcer nursing emulsifiable paste and preparation method thereof Download PDFInfo
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- CN106466309A CN106466309A CN201510514147.7A CN201510514147A CN106466309A CN 106466309 A CN106466309 A CN 106466309A CN 201510514147 A CN201510514147 A CN 201510514147A CN 106466309 A CN106466309 A CN 106466309A
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- emulsifiable paste
- radiation
- induced skin
- skin ulcer
- nurses
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- 206010040943 Skin Ulcer Diseases 0.000 title claims abstract description 16
- 230000005855 radiation Effects 0.000 title claims abstract description 16
- 231100000019 skin ulcer Toxicity 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims description 8
- 230000000474 nursing effect Effects 0.000 title claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 15
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 10
- JAONZGLTYYUPCT-UHFFFAOYSA-K bismuth subgallate Chemical compound OC(=O)C1=CC(O)=C2O[Bi](O)OC2=C1 JAONZGLTYYUPCT-UHFFFAOYSA-K 0.000 claims abstract description 9
- 229960000199 bismuth subgallate Drugs 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 8
- 229940099259 vaseline Drugs 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 6
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 6
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 5
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229940075507 glyceryl monostearate Drugs 0.000 claims abstract description 5
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 5
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims abstract description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000008117 stearic acid Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000012071 phase Substances 0.000 claims description 5
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- 229940076134 benzene Drugs 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000002068 microbial inoculum Substances 0.000 claims description 2
- 230000001629 suppression Effects 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 239000000022 bacteriostatic agent Substances 0.000 claims 2
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 claims 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 1
- 235000009392 Vitis Nutrition 0.000 claims 1
- 241000219095 Vitis Species 0.000 claims 1
- DHOCGIHFPKXZJB-UHFFFAOYSA-N [Cl+].N[H] Chemical compound [Cl+].N[H] DHOCGIHFPKXZJB-UHFFFAOYSA-N 0.000 claims 1
- 229960003260 chlorhexidine Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 abstract description 9
- 231100000397 ulcer Toxicity 0.000 abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 230000035876 healing Effects 0.000 abstract description 5
- 206010018691 Granuloma Diseases 0.000 abstract description 4
- 230000004888 barrier function Effects 0.000 abstract description 3
- 208000003322 Coinfection Diseases 0.000 abstract description 2
- 241000233866 Fungi Species 0.000 abstract description 2
- 241000700605 Viruses Species 0.000 abstract description 2
- 230000004520 agglutination Effects 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 229960004274 stearic acid Drugs 0.000 abstract description 2
- 239000010409 thin film Substances 0.000 abstract description 2
- 239000000877 Sex Attractant Substances 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000002352 surface water Substances 0.000 abstract 1
- 229960004418 trolamine Drugs 0.000 abstract 1
- 208000019155 Radiation injury Diseases 0.000 description 6
- 210000004877 mucosa Anatomy 0.000 description 6
- 230000006378 damage Effects 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 208000009084 Cold Injury Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000002595 cold damage Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008472 epithelial growth Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A kind of radiation-induced skin ulcer nurses emulsifiable paste, and the raw material making described emulsifiable paste effective ingredient consists of：Vaseline, bismuth subgallate, Borneolum Syntheticum, stearic acid, glyceryl monostearate, ethyl hydroxybenzoate, triethanolamine, benzalkonium chloride, glycerol, polyoxyethylene sorbitan monoleate, water, liquid paraffin.The sex pheromones such as antibacterial, funguses, virus can effectively be killed by emulsifiable paste of the present invention, and can form one layer of barrier oiliness thin film in ulcer surface, prevent secondary infection.Avoid ulcer surface water loss simultaneously, provide Moist healing environment for ulcer surface, and the bad results such as incrustation or granuloma will not be caused in agglutination.
Description
Technical field
The invention belongs to field of medicine preparations is and in particular to a kind of radiation-induced skin ulcer nurses emulsifiable paste and preparation method thereof.
Background technology
Skin is distributed mankind's body surface with mucosa, as the barrier of human body and external environment, skin and mucosa, particularly skin,
Mechanicalness (as hurt), physical property (as scald or cold injury) and the chemical (such as contacting chemical agent) being vulnerable in environment
Injury.
Tumor patient radiation injury refers to be subject to lonizing radiation external exposure or radionuclide to be infected with when body whole body or local
When, the damage being occurred by actinism is referred to as radiation injury of skin.Radiation injury of skin includes acute radiation injury, chronic
Radiation injury and radioactive skin cancer.
After skin or mucosa come to harm, the different degrees of external symptom such as redness, heating and pain can be caused, process not
Infect when causing, or even involve whole body.Radiation injury in recovery phase it is also possible to because tissue regeneration cause cicatrization,
Lead to granuloma telangiectaticum (purulent granuloma), make neoplastic skin pigmentation and surface horny, when serious
Outward appearance can be affected.
The present invention devises a kind of radiation-induced skin ulcer nursing emulsifiable paste and preparation method thereof, and it can not only reduce to injured skin
Skin, the stimulation of mucosa, and the bad result such as incrustation, granuloma will not be caused in skin ulcer agglutination, make new life simultaneously
Skin or mucosa keep soft and elastic.
Content of the invention
This patent provides a kind of radiation-induced skin ulcer to nurse emulsifiable paste, and it can kill the micro- life of the source of disease such as antibacterial, funguses, virus
Thing, forms one layer of barrier oiliness thin film at ulcer simultaneously, prevents secondary infection.There is certain molecule permeability, energy
Maintain skin synchronously to breathe, and the moistening healing environment of cell regeneration is provided, keep ulcer surface moisture penetration balance, promote meat
Bud tissue and epithelial tissue growth, accelerate the healing of ulcer.
For reaching above-mentioned purpose, the technical solution used in the present invention is：
A kind of radiation-induced skin ulcer nursing emulsifiable paste it is characterised in that：Vaseline, bismuth subgallate, Borneolum Syntheticum, anti-
(suppression) microbial inoculum and emulsifiable paste matrix Synergistic.
Vaseline：Stop blooding, slow down pain, prevent ulcer, accelerate ulcer healing；
Bismuth subgallate：Astringency and antiseptic, are used for outward the dermatosiss such as eczema；
Borneolum Syntheticum：Diminish inflammation, promote rotten to the corn and ulcer healing, to the mucosa lesions caused by antibacterial or other complicated factors,
Auxiliary therapeutic action can be played.
A kind of radiation-induced skin ulcer nursing emulsifiable paste and preparation method thereof is it is characterised in that its formulation weight percentage ratio is：
Described antibacterial can be that parabenses, chlorhexidine gluconate, benzalkonium chloride, benzene prick bromine by, cetylpyridinium chloride
One or more of；Being best suitable for antibacterial is one of ethyl hydroxybenzoate, benzalkonium chloride or two kinds.
The preparation method of the present composition is：
(1) take 75 DEG C～80 DEG C heating for dissolving of vaseline, more respectively by Borneolum Syntheticum, stearic acid, glyceryl monostearate,
Ethyl hydroxybenzoate is dissolved in wherein, adds liquid paraffin, obtains oil phase.
(2) take bismuth subgallate, add water, add after triethanolamine makes bismuth subgallate be completely dissolved,
Add glycerol, 75 DEG C～80 DEG C heating, obtain aqueous phase.
(3) when oil, water biphase isothermal, oil phase is slowly added in aqueous phase, and adds polyoxyethylene sorbitan monoleate, maintain
70 DEG C of stirring 20min, stir to cooling, you can.
Specific embodiment
Embodiment one
A kind of radiation-induced skin ulcer nurses emulsifiable paste, is mainly made up of following supplementary material：Vaseline 5g, bismuth subgallate
4.0g, Borneolum Syntheticum 1.2g, stearic acid 12.0g, glyceryl monostearate 8.0g, triethanolamine 0.1g, glycerol 13.0g,
Polyoxyethylene sorbitan monoleate 2.0g, liquid paraffin 2.0g, ethyl hydroxybenzoate 0.3g, benzalkonium chloride 0.1g, water 52.3g.
Embodiment two
A kind of radiation-induced skin ulcer nurses emulsifiable paste, is mainly made up of following supplementary material：Vaseline 7.0g, alkali formula gallic acid
Bismuth 5.0g, Borneolum Syntheticum 1.0g, stearic acid 14.0g, glyceryl monostearate 9.0g, triethanolamine 0.2g, glycerol 13.0g,
Polyoxyethylene sorbitan monoleate 3.0g, liquid paraffin 3.0g, ethyl hydroxybenzoate 0.2g, water 44.6g.
The emulsifiable paste of the present embodiment, when using, takes appropriate, is applied on the gauze of suitable wound size, the daily morning, noon and afternoon are each
Once, it is to avoid site of injury contacts water.
Foregoing is illustrative of multiple case study on implementation of the present invention, those of ordinary skill in the art can be in claims
Within the scope of various modification can be adapted equivalent, without departing from the protection domain described by the claim of the present invention, all should
Within protection scope of the present invention.
Claims (5)
1. a kind of radiation-induced skin ulcer nursing emulsifiable paste is it is characterised in that the vaseline of effective dose, Borneolum Syntheticum, bismuth subgallate, anti-
(suppression) microbial inoculum and suitable emulsifiable paste matrix.Its composition of raw materials is following (by weight percentage)：
2. a kind of radiation-induced skin ulcer according to claim 1 nurses emulsifiable paste, and its bacteriostatic agent is parabenses, Fructus Vitis viniferae
Saccharic acid chlorhexidine, benzalkonium chloride, benzene prick bromine press, one or more of cetylpyridinium chloride.
3. a kind of radiation-induced skin ulcer according to claim 2 nurses emulsifiable paste, and its bacteriostatic agent is ethyl hydroxybenzoate, benzene pricks chlorine
Ammonium.
4. a kind of radiation-induced skin ulcer according to claim 1 nurses emulsifiable paste, and its composition of raw materials is following (by weight percentage
Meter)：
5. according to claim 4 nurse cream preparation method it is characterised in that following technique for a kind of radiation-induced skin ulcer
Step：
(1) 75 DEG C～80 DEG C heating for dissolving of vaseline are taken, more respectively by Borneolum Syntheticum, stearic acid, glyceryl monostearate, oxybenzene second
Ester is dissolved in wherein, adds liquid paraffin, obtains oil phase.
(2) take bismuth subgallate, add suitable quantity of water, add after triethanolamine makes bismuth subgallate be completely dissolved,
Add glycerol, 75 DEG C～80 DEG C heating, obtain aqueous phase.
(3) when oil, water biphase isothermal, oil phase is slowly added in aqueous phase, and adds polyoxyethylene sorbitan monoleate, maintain 70 DEG C
Stirring 20min, stirs to cooling, you can.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510514147.7A CN106466309A (en) | 2015-08-20 | 2015-08-20 | A kind of radiation-induced skin ulcer nursing emulsifiable paste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510514147.7A CN106466309A (en) | 2015-08-20 | 2015-08-20 | A kind of radiation-induced skin ulcer nursing emulsifiable paste and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106466309A true CN106466309A (en) | 2017-03-01 |
Family
ID=58229371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510514147.7A Pending CN106466309A (en) | 2015-08-20 | 2015-08-20 | A kind of radiation-induced skin ulcer nursing emulsifiable paste and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106466309A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109303764A (en) * | 2018-10-26 | 2019-02-05 | 山东贝诺医药生物科技有限公司 | A kind of chitosan cream and its preparation process preventing and treating radioactive skin reaction |
| CN113134075A (en) * | 2021-04-29 | 2021-07-20 | 江苏普莱医药生物技术有限公司 | Antibacterial peptide emulsifiable paste and preparation method thereof |
-
2015
- 2015-08-20 CN CN201510514147.7A patent/CN106466309A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109303764A (en) * | 2018-10-26 | 2019-02-05 | 山东贝诺医药生物科技有限公司 | A kind of chitosan cream and its preparation process preventing and treating radioactive skin reaction |
| CN113134075A (en) * | 2021-04-29 | 2021-07-20 | 江苏普莱医药生物技术有限公司 | Antibacterial peptide emulsifiable paste and preparation method thereof |
| CN113134075B (en) * | 2021-04-29 | 2024-05-10 | 江苏普莱医药生物技术有限公司 | Antibacterial peptide cream and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170301 |
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| WD01 | Invention patent application deemed withdrawn after publication |