CN101612203B - Traditional Chinese medicine composition used for treating pointed condyloma and application thereof - Google Patents
Traditional Chinese medicine composition used for treating pointed condyloma and application thereof Download PDFInfo
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- CN101612203B CN101612203B CN2009100412782A CN200910041278A CN101612203B CN 101612203 B CN101612203 B CN 101612203B CN 2009100412782 A CN2009100412782 A CN 2009100412782A CN 200910041278 A CN200910041278 A CN 200910041278A CN 101612203 B CN101612203 B CN 101612203B
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Abstract
The invention discloses a traditional Chinese medicine composition used for treating pointed condyloma, comprising the following components according to parts by weight: 200 to 700 parts of olive and 100 to 400 parts of Chinese black olive leaf. The invention also discloses an application of the medicine composition used for treating pointed condyloma, which serves as an active substance used forpreparing a pharmaceutical preparation for treating pointed condyloma. The invention uses natural Chinese herbal medicines of the olive and the Chinese black olive leaf as the raw materials, has safeand convenient use, obvious curative effect, very low relapse rate after being used and small toxic or side effect of the medicine and eliminates adverse reactions, such as dissipated skin, inflammation and the like occurring after the existing medicine is used.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and application thereof, relate in particular to a kind of Chinese medicine composition and application thereof that is used for the treatment of condyloma acuminatum.
Background technology
Condyloma acuminatum is detectable a kind of wart on skin or genitals mucosa, is caused by human papillomavirus (HPV).Clinical symptoms comes across and infected the back 1～6 month, average out to 3 months, but the patient can not note these symptoms usually.This wart shows as distinguished mamillary or cockscomb sample tumor, and accumulation and multiple tendency are arranged, and is generally redness or brownish red.The method that detects condyloma acuminatum is the DNA that gets tissue or determine described virus from the infection site smear then.According to this method, verification and measurement ratio is almost 100%.The HPV6 of this virus and 11 types be the most normal detect kind owing to detected HPV16, so HPV16 is relevant with pernicious condyloma acuminatum probably from the pernicious squamous cell cancerous protuberance of carcinoma of penis, cervical cancer and condyloma acuminatum.
There not being specific antiviral drugs aspect the treatment of condyloma acuminatum, can only adopt Comprehensive Treatment.And the Therapeutic Principle of wart is mainly comprised 3 aspects:
1. directly destroy and remove the wart tissue.
2. the Verrucosis change is embrocated in medication repeatedly, makes intraepidermal HPV antigen-exposed in intradermal immune system, thereby sets up and bring into play complete immunologic function, to remove the wart tissue.
3. improve body whole body or local immunity power, improve the ability of anti-HPV.
Present Therapeutic Method has:
1. physics and operative therapy: as: to fulgerize, freezing, laser, microwave, strike off etc., for bigger wart body and function excision. the advantage of this therapy is to remove visible wart body quickly and accurately; Shortcoming is to cause pain easily, needs anesthesia, and some operation is comparatively complicated, and damage is bigger, and bacterial infection etc. takes place postoperative easily.
2. external chemicals: phthiobuzone, 5-fluorouracil, podophyllum ester, podophyllum ester element, clean, the trichloroacetic acid of scar rash, the solution of Bleomycin A5 etc., cream or ointment.Its advantage is 1. easy to use, and some medicine patient oneself can grasp use; 2. the patient is damaged little.Its deficiency is: 1. administration time is long, needs a few days, several weeks, even the several months; 2. relatively poor to the condyloma acuminatum curative effect on the skin big, that hypertrophy speed is very fast and horny layer is thicker; 3. cause local edema, erosion in various degree after the medication, in addition downright bad.
3. constitutional treatment: use antiviral agents, as acyclovir, interferon, antiviral Chinese medicine such as Folium Isatidis, Radix Isatidis, Radix Bupleuri etc. weak curative effect, the course of treatment are long.
4. external Chinese medicine: in order to Fructus Bruceae is that the preparation of main component is coated with outward, with the medicine fumigation and wash method with heat-clearing and toxic substances removing dispelling wind eliminating stagnation (antiviral) effect.Need multiple dosing, the course of treatment is long, and Fructus Bruceae is big to the zest of normal skin, mucosa.
Though above treatment measure can both be cured condyloma acuminatum to a certain extent, considers infection site, surgical operation can bring misery to the patient, and topical has side effect, even and cured and also be easy to generate recurrence.Therefore also there is not compellent Therapeutic Method at present.
Summary of the invention
First purpose of the present invention is to provide a kind of Chinese medicine composition that is used for the treatment of condyloma acuminatum.
The objective of the invention is to realize by following technical measures: a kind of Chinese medicine composition that is used for the treatment of condyloma acuminatum comprises the component of following weight portion:
100～400 parts of 200～700 parts of Folium Canarii Pimelae of Folium olive.
Folium olive has heat-clearing and toxic substances removing, the effect of reducing swelling and alleviating pain, and have the virus of killing, antibacterial, fungus and parasite through current clinical medicine proof Folium olive, and the effect that improves immunity.Folium Canarii Pimelae has heat-clearing and toxic substances removing, and the hemostatic effect cures mainly erysipelas; Furuncle and phyma is put down in writing it and " is washed the abnormal pigmentary deposit on the skin poison " in " the SHENGCAO property of medicine is wanted fully ".Folium olive and Folium Canarii Pimelae compatibility are played heat-clearing and toxic substances removing altogether, sterilizing and itch-relieving, and the effect of reducing swelling and alleviating pain, being used for the treatment of condyloma acuminatum has obvious curative effects.
Preferred component content of the present invention is: 100～300 parts of 200～600 parts of Folium Canarii Pimelae of Folium olive.
Best composition content of the present invention is: 200～300 parts of 400～600 parts of Folium Canarii Pimelae of Folium olive.
Chinese medicine composition provided by the invention is through decocting with water immersion or the washout that the medicinal liquid that obtains is used for the affected part, and each 10～15 minutes, each once came off through promptly occurring white dead bark after 4～5 days the use sooner or later, uses for 2～3 weeks continuously.If when the state of an illness is heavier, can extend working time.
Second purpose of the present invention is to provide the application of above-mentioned Chinese medicine composition in the pharmaceutical preparation of preparation treatment condyloma acuminatum.
Chinese medicine composition of the present invention can be prepared into the pharmaceutical preparation of treatment condyloma acuminatum by the active substance of existing conventional Chinese medicine preparation extraction Chinese medicine composition, as oral formulations, external preparation.Wherein, oral formulations comprises tablet, capsule, granule and powder.Exterior-applied formulation then comprises liniment, paste, Emulsion, cream, lotion, membranous patch and ointment. can be equipped with different pharmaceutically suitable carrier according to the dosage form needs, simultaneously can add antioxidant, transdermal enhancer, heat preserving agent, emulsifying agent, stabilizing agent, antifungus agent, spice and pigment.Preferred carrier is active component bigger those of dissolubility therein.The pharmaceutically suitable carrier that is most commonly used to medicament of the present invention is water, ethanol and composition thereof, thereby medicament of the present invention can be made liniment, paste, Emulsion.Can also comprise the reagent of giving color or fragrance in the pharmaceutical composition of the present invention.In addition, these compositionss can comprise other medicines, wound sealant, carrier etc., and they are for well known by persons skilled in the art or conspicuous.
The present invention compared with prior art has following beneficial effect:
The present invention is with natural Chinese herbal medicines---and Folium olive and Folium Canarii Pimelae are raw material, and be safe in utilization, convenient, evident in efficacy, and extremely low with the back relapse rate, poisonous side effect of medicine is little, and eliminated untoward reaction such as the skin erosion that occurs after the existing drug use, redness.
The present invention treats and suffers from condyloma acuminatum patient 1000 examples, and cured person 613 examples are cured the back and do not noted health recidivist 387 examples because of daily, and effective percentage is 61.3%, and following model case has proved effect of the present invention and had no side effect:
Case 1: Zhou Daxing, the man, 46 years old, 2003 is ill, adopt fulgerize, method treatment such as freezing, laser is all invalid.Through using the present invention's treatment, medication was fully recovered after 4 months.So far do not see recurrence.
Case 2: Wang Yongshen, the man, 49 years old, ill more than 2 years, adopt micro-wave therapeutic, beta rays treatment, also use medicine for external use such as podophyllum ester, phthiobuzone cream, iodouracil desoxyriboside ointment, but cure not yet.Fully recover after using the present invention to treat half a year, do not see recurrence so far.
Case 3: Liang Daquan, the man 47 years old, ill 3 years, once did excision, and uses the phthiobuzone cream and take acyclovir, but do not cure.Fully recover after using the present invention to treat half a year, do not see recurrence so far.
Case 4: Qian Qiuan, 38 years old, ill 2 years, carried out cold therapy, also took interferon and interleukin, but all to no effect.Use the present invention to treat recovery from illness after 5 months, do not see recurrence so far.
The specific embodiment
Below in conjunction with embodiment the present invention is set forth, yet protection scope of the present invention is not only to be confined to following examples.The person of an ordinary skill in the technical field all can realize purpose of the present invention according to content disclosed by the invention.
Embodiment one: the preparation of decoction
Prescription: Folium olive 500g, Folium Canarii Pimelae 250g.
Preparation method: fresh Folium olive and Folium Canarii Pimelae were soaked 12 hours, and amount of water was not advisable to have powder, decocted 2 hours, filtered then, promptly got decoction.
Using method: use acetic acid earlier to affected part disinfection (if the wound that the affected part has laser and operative treatment to form then need not to use acetic acid to come disinfection), then this product is soaked the affected part, sooner or later each once uses after 4～5 days, and affected part adularescent dead bark comes off.2～3 week of continuous use.For what be in a bad way, can extend working time.
Embodiment two: the preparation of liniment
Prescription: Folium olive 500g, Folium Canarii Pimelae 250g.
Preparation method: fresh Folium olive and Folium Canarii Pimelae were soaked 12 hours, and amount of water was not advisable to have powder, decocted 2 hours, filtered to get filtrate then, and filtrate is condensed into extractum, made liniment according to the liniment preparation method of routine then and got final product.
Using method: use acetic acid earlier to affected part disinfection (if the wound that the affected part has laser and operative treatment to form then need not to use acetic acid to come disinfection), then this product is coated in the affected part, every day 3 times, use after 4～5 days, affected part adularescent dead bark comes off.2～3 week of continuous use.For what be in a bad way, can extend working time.
Embodiment two: the preparation of ointment
Prescription: Folium olive 200g, Folium Canarii Pimelae 100g.
Preparation method: fresh Folium olive and Folium Canarii Pimelae were soaked 10 hours, and amount of water was not advisable to have powder, decocted 1 hour, filtered to get filtrate then, and filtrate is condensed into extractum, made ointment according to the preparation method of the ointment of routine then and got final product.
Using method: use acetic acid earlier to affected part disinfection (if the wound that the affected part has laser and operative treatment to form then need not to use acetic acid to come disinfection), then this product is coated in the affected part, use every day 3～6 times, use after 4～5 days, affected part adularescent dead bark comes off, 2～3 week of continuous use.For what be in a bad way, can extend working time.
Embodiment three: the preparation of membrane
Prescription: Folium olive 700g, Folium Canarii Pimelae 350g.
Preparation method: fresh Folium olive and Folium Canarii Pimelae were soaked 8 hours, and amount of water was not advisable to have powder, decocted 1.5 hours, filtered to get filtrate then, and filtrate is condensed into extractum, made membrane according to the preparation method of the membrane of routine then and got final product.
Using method: use acetic acid to affected part disinfection (if the wound that the affected part has laser and operative treatment to form then need not to use acetic acid to come disinfection) earlier, then this product is attached to the affected part, 2～3 week of continuous use.For what be in a bad way, can extend working time.
Embodiment four: the preparation of tablet
Prescription: Folium olive 600g, Folium Canarii Pimelae 400g.
Preparation method: fresh Folium olive and Folium Canarii Pimelae were soaked 8 hours, and amount of water was not advisable to have powder, decocted 1.5 hours, filtered to get filtrate then, and filtrate is condensed into extractum, made tablet according to the preparation method of the tablet of routine then and got final product.
Embodiment five: the preparation of granule
Prescription: Folium olive 300g, Folium Canarii Pimelae 300g.
Preparation method: fresh Folium olive and Folium Canarii Pimelae were soaked 12 hours, and amount of water was not advisable to have powder, decocted 2 hours, filtered to get filtrate then, and filtrate is condensed into extractum, made granule according to the preparation method of the granule of routine then and got final product.
Embodiment six: the preparation of capsule
Prescription: Folium olive 400g, Folium Canarii Pimelae 400g.
Preparation method: fresh Folium olive and Folium Canarii Pimelae were soaked 10 hours, and amount of water was not advisable to have powder, decocted 2 hours, filtered to get filtrate then, and filtrate is condensed into extractum, made capsule according to the preparation method of the capsule of routine then and got final product.
Claims (7)
1. a Chinese medicine composition that is used for the treatment of condyloma acuminatum is characterized in that, its crude drug is made up of the component of following weight portion:
100～400 parts of 200～700 parts of Folium Canarii Pimelae of Folium olive.
2. the Chinese medicine composition that is used for the treatment of condyloma acuminatum according to claim 1 is characterized in that, described constituent content is:
100～300 parts of 200～600 parts of Folium Canarii Pimelae of Folium olive.
3. the Chinese medicine composition that is used for the treatment of condyloma acuminatum according to claim 1 is characterized in that, described constituent content is:
200～300 parts of 400～600 parts of Folium Canarii Pimelae of Folium olive.
4. arbitrary described Chinese medicine composition that is used for the treatment of condyloma acuminatum is used for preparing the application of the pharmaceutical preparation for the treatment of condyloma acuminatum in the claim 1～3 as active substance.
5. the Chinese medicine composition that is used for the treatment of condyloma acuminatum according to claim 4 is used for preparing the application of the pharmaceutical preparation for the treatment of condyloma acuminatum as active substance, it is characterized in that described pharmaceutical preparation is local topical preparation or oral formulations.
6. the Chinese medicine composition that is used for the treatment of condyloma acuminatum according to claim 5 is used for preparing the application of the pharmaceutical preparation for the treatment of condyloma acuminatum as active substance, it is characterized in that described local topical preparation is liniment, paste, Emulsion, lotion, membranous patch and ointment.
7. the Chinese medicine composition that is used for the treatment of condyloma acuminatum according to claim 5 is used for preparing the application of the pharmaceutical preparation for the treatment of condyloma acuminatum as active substance, it is characterized in that described oral formulations is tablet, capsule, granule and powder.
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| CN101984987B (en) * | 2010-11-01 | 2011-11-16 | 黄品月 | Traditional Chinese medicine formula for reducing hypertension |
| CN103110748B (en) * | 2013-02-09 | 2015-08-12 | 隋丽梅 | Compound traditional Chinese medicine composite of a kind for the treatment of venereal and uses thereof |
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