CN106390277A - Pressure-controlled flexible microneedle drug delivery system - Google Patents
Pressure-controlled flexible microneedle drug delivery system Download PDFInfo
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- CN106390277A CN106390277A CN201610855409.0A CN201610855409A CN106390277A CN 106390277 A CN106390277 A CN 106390277A CN 201610855409 A CN201610855409 A CN 201610855409A CN 106390277 A CN106390277 A CN 106390277A
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- 238000012377 drug delivery Methods 0.000 title abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 40
- 239000007787 solid Substances 0.000 claims abstract description 22
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 8
- 229920002120 photoresistant polymer Polymers 0.000 claims abstract description 5
- 239000012530 fluid Substances 0.000 claims description 6
- 239000004744 fabric Substances 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 14
- 230000008569 process Effects 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 10
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000013271 transdermal drug delivery Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 43
- 239000000843 powder Substances 0.000 description 12
- 238000007920 subcutaneous administration Methods 0.000 description 9
- 238000004891 communication Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 229920005570 flexible polymer Polymers 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910021421 monocrystalline silicon Inorganic materials 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to a microneedle drug delivery system, and especially relates to a pressure-controlled flexible microneedle drug delivery system. With respect to the pressure-controlled flexible microneedle drug delivery system, a drug-unloaded solid microneedle array made of SU-8 Negative photoresist is employed, and a microfluid network and a microfluid channel made of polydimethylsiloxane are integrated at the same time. Compared with a conventional disposable microneedle device, the pressure-controlled flexible microneedle drug delivery system is advantaged in that the drug-unloaded solid microneedle array is employed, the needle body cannot be ruptured easily, and can be used safely; the microfluid channel and the microfluid network are integrated in the microneedle drug delivery system and are used for achieving the whole process from drug charging to transdermal drug delivery, the pressure-controlled flexible microneedle drug delivery system can be used more easily, and can be reused, and has a high economic benefit.
Description
Technical field
The present invention relates to a kind of micropin drug-supplying system, more particularly to a kind of pressure-controlled flexibility micropin drug-supplying system.
Background technology
Drug therapy is a kind of common medical procedure, and the main mode of movement that medicine enters human body includes injection and mouth
Clothes, both modes all have some limitations.Medicine in oral period because of self metabolism thus losing curative effect；Skin
Lower injection needs trained personnel could implement, and brings the risk of unavoidable pain and infection to sufferer,
Make troubles to patient.In recent years, micropin administering mode increasingly attracts the concern of people.Micropin is a kind of similar injection needle
Micron order is hollow or solid needle, be typically made using single crystal silicon material, metal or high molecular polymer.It can be lucky
Do not touch pain nerve through horny layer, play the damage that drug osmotic effect creates a painful feeling with skin corium simultaneously and not.
Empty micropin refers to that one group of overall dimensions are similar to solid-state micropin, has along on the axis of pin with tradition function of injection
Similar aperture.Compared with solid microneedles, its intensity be enough to pierce skin, allows fluid from, by drug solution during application again
Filling cavity, or medicinal liquid is entered internal by pin hole in necessarily outer pressure.After empty micropin pierces skin, it is right that skin can produce
The resistance of anti-microneedle injection, the inflow of impact needle body inner liquid medicine, operational efficiency is low.But the presence due to hollow channel, hollow micro-
The physical arrangement of pin built on the sand.In administration process, the doser loading empty micropin is relative with what skin surface produced
Displacement can lead to the phenomenon of micropin fracture to occur, and easily causes malpractice.
Solid microneedles can be divided into load medicine solid microneedles and not carry medicine solid microneedles two class.
Carry medicine solid microneedles to pass through Spray coating methods, dip coating method etc. medicine is wrapped in needle body surface.Due to needle body
With the effect of medical surfaces tension force, the drug loading of micropin is very low, can affect the acutance of needle body, may lead to needle body after packaging medicine
Skin can not smoothly be pierced；Solubility carries medicine solid microneedles by can dissolve or the macromolecular material of degradable is formed, and medicine passes through
Mix with macromolecular material, be directly present in needle body, after needle body pierces skin, the medicine being dissolved in needle body starts to discharge.Can
Dissolubility micropin overcomes the defect that empty micropin and coating micropin may rupture in use.But relate in mixed process
And the use of organic solvent, skin irritation can be produced.Some preparation conditions, such as higher temperature, macromolecular drug can be affected
Stability, reduce pharmaceutically active.When needle body load medicine exceedes certain limit, the mechanical performance of needle body can be affected.
Do not carry medicine solid microneedles realize drug percutaneous import be made up of two steps：After micropin acts on skin, can temporarily break
The barrier action of keratodermatitis, sets up substantial amounts of subcutaneous micro-channel；Medicine enters skin by subcutaneous micro-channel.Micropin moves
After removing, subcutaneous micro-channel can fade away.Comparatively, not carrying medicine solid microneedles is a kind of safer administration tool.
It is to guarantee that medicine is not contaminated during powder charge and loading that tradition does not carry medicine solid microneedles device, its powder charge and defeated
Medicine process is complicated, leads to user using inconvenience.The not reproducible use of traditional micropin device, causes the wasting of resources.
Based on the advantage not carrying medicine solid microneedles, in order to overcome the above-mentioned deficiencies of the prior art, the present invention devises one kind
Pressure-controlled flexibility micropin drug-supplying system, described one kind pressure-controlled flexibility micropin drug-supplying system is made using by the negative photoresist of SU-8
Do not carry medicine solid array of microneedles, incorporate the microfluidic networks being made up of polydimethylsiloxane and microfluidic channel simultaneously.
Compared with traditional disposable micropin device, described micropin drug-supplying system is not easily broken using not carrying medicine solid array of microneedles, needle body
Split, using safety；Described micropin drug-supplying system incorporates microfluidic channel and microfluidic networks, is used for realizing powder charge defeated to transdermal
The whole process of medicine, improves the ease for use of equipment, reusable, high financial profit.
Content of the invention
Invent described one kind pressure-controlled flexibility micropin drug-supplying system to include：Microfluidic channel, microneedle array and micro fluidic network
Network.Microfluid distribution network leaves opening at its each network branches top, and opening is evenly distributed in the bottom of microneedle array, micro-
Fluid passage is connected with microfluidic networks.
Described microfluidic channel is made up of polydimethylsiloxane, including Micropump, check valve and microfluidic networks access section
Point.
Described Micropump loading liquid or gas, are connected with check valve.
Described check valve includes inputting check valve and output one-way valve, and input check valve is connected with Micropump, and output is unidirectional
Valve is connected with Micropump and microfluidic networks access section split-phase.
Described microfluidic networks access part is connected with microfluidic channel and microfluidic networks.
Two check valves only allow gas or liquid to flow toward a direction, and finger is pressed to Micropump and unclasped behaviour
Make, pressure difference inside and outside the deformation generation of Micropump, thus realizing the gas in described micropin drug-supplying system or liquid are driven,
Complete powder charge and the loading link of microneedle device.
Described microneedle array be one be no less than 5 × 5 do not carry medicine solid microneedles, micropin by SU-8 bear photoresist make.
When described micropin administration device applies on a skin surface, these micropins can penetrate horny layer and build in bio-tissue
Found subcutaneous micro-channel.
Described microfluidic networks are made up of one group of symmetrical microfluidic networks branch, microfluidic networks each branch top
Leave opening, opening is evenly distributed in the bottom of described microneedle array, each branch of microfluidic networks is connected with microfluidic channel
Logical.
The medicine being loaded in described flexibility micropin administration device is driven by Micropump, flows to microfluid by output one-way valve
The each branch of network, flows out to microneedle array surface by the top end opening of each branch, is formed in bio-tissue by micropin
Subcutaneous micro-channel be transported in subcutaneous tissue.
One kind of the present invention pressure-controlled flexibility micropin drug-supplying system feature is：
1. overall structure is made up to dimethyl siloxane of flexible polymer, has the characteristic of flexibility, pro-skin；
2. the control of powder charge is to unclasp operation to complete after Micropump once being pressed by user, and the external pressure of Micropump is powerful
In interior pressure so that outside medicinal liquid passes through to input in check valve inflow Micropump, complete powder charge process；
3. the control of loading is to carry out pressing operation to Micropump to complete by user, the intrinsic pressure powerful and outer pressure of Micropump, makes
The medicinal liquid obtaining in Micropump flows into microfluidic networks by output one-way valve, completes loading process；
4. microfluidic networks to be for the purpose of distributing medicinal liquid, the symmetrical bottom being distributed in microneedle array of the top end opening of microfluidic networks
Portion, medicinal liquid is evenly distributed in the surface of microneedle array after opening；
5., when micropin administration device described in applies on a skin surface, do not carry medicine solid microneedles and penetrate horny layer and in organism group
Knit middle set up subcutaneous micro-channel so that the medicinal liquid body on microneedle array surface pass through to enter in subcutaneous micro-channel biological internal.
One kind of the present invention pressure-controlled flexibility micropin drug-supplying system has following benefit：
1. micropin drug-supplying system bio-compatibility of the present invention is good, is not result in the untoward reaction such as allergy；
2. micropin drug-supplying system of the present invention possesses the feature of flexibility, can be very good skin of fitting, and wear comfort is high；
3. the micropin of micropin drug-supplying system of the present invention is not carry medicine solid microneedles, uses safely and effectively；
4. micropin drug-supplying system of the present invention is when using, powder charge link and loading link simple to operate；
5. micropin drug-supplying system of the present invention repeats and completes powder charge and loading process, recycles, it is to avoid disposable waste,
High financial profit；
6. dosing paster of the present invention to carry out drug delivery using the microfluidic channel of closing, and medicine can be avoided to be transmitted across
Pollution in journey.
Brief description
Fig. 1 is a kind of pressure-controlled flexibility micropin drug-supplying system hierarchical diagram.
Fig. 2 is a kind of pressure-controlled flexibility micropin drug-supplying system the 1st Rotating fields figure.
Fig. 3 is a kind of pressure-controlled flexibility micropin drug-supplying system the 2nd Rotating fields figure.
Fig. 4 is a kind of pressure-controlled flexibility micropin drug-supplying system 3-tier architecture figure.
Fig. 5 is a kind of pressure-controlled flexibility micropin drug-supplying system the 4th Rotating fields figure.
Fig. 6 is a kind of pressure-controlled flexibility micropin drug-supplying system the 5th Rotating fields figure.
Fig. 7 is described micropin drug-supplying system microneedle array top view.
Fig. 8 is described micropin drug-supplying system microfluidic networks top view.
Fig. 9 is described micropin drug-supplying system microfluidic channel side view.
Figure 10 is described micropin drug-supplying system microfluidic channel working stage 1 schematic diagram.
Figure 11 is described micropin drug-supplying system microfluidic channel working stage 2 schematic diagram.
Figure 12 is described micropin drug-supplying system microfluidic channel working stage 3 schematic diagram.
Specific embodiment
The present invention is achieved by the following technical solutions：
One kind of the present invention pressure-controlled flexibility micropin drug-supplying system, as shown in figure 1, include 5 layers.1 for layer 1,2 for layer 2,3 is
Layer 3,4 is that layer 4,5 stacks gradually combination for layer 5,1～5, and wherein 1 is top layer, and 5 is bottom.Described micropin drug-supplying system is by gathering
Dimethyl siloxane is made.
The 1st layer of described a kind of pressure-controlled flexibility micropin drug-supplying system, as shown in Fig. 21 includes the micropin of 11 × 11
Array 6 and the microfluidic networks top end opening 7 being symmetrically distributed in microneedle array bottom, microfluidic networks top end opening and micropin battle array
The distribution relation of row is as shown in Figure 7.When described micropin drug-supplying system applies on a skin surface, microneedle array 6 can penetrate
Horny layer simultaneously sets up subcutaneous micro-channel in bio-tissue, and medicinal liquid flows from microfluidic networks top end opening 7 after being driven
Go out, and administration process is realized in vivo by the subcutaneous micro-channel entrance set up.The substrate 8 of layer 1 is by polydimethylsiloxane
Make, described microneedle array 6 is born photoresist by SU-8 and made.
The 2nd layer of described a kind of pressure-controlled flexibility micropin drug-supplying system, as shown in figure 3,2 include microfluidic networks 9.Described
Microfluidic networks 9 are formed by each microfluidic networks branch Symmetric Composite, and described each microfluidic networks top end opening 7 is micro fluidic network
The open top of each branch of network 9.The connection such as relation of microfluidic networks 9 and microfluidic channel is as shown in figure 8, microfluidic networks are each
Branch accesses passage 10 with the microfluidic networks of microfluidic channel and is connected.The substrate 20 of layer 2 is made up of polydimethylsiloxane.
The 2～5 of described a kind of pressure-controlled flexibility micropin drug-supplying system are combined into microfluidic channel, such as Fig. 3, Fig. 4, Fig. 5, figure
Shown in 6.The substrate of the substrate 28 and 5 of 3 substrate 24,4 is made up of polydimethylsiloxane.The miniflow of described micropin drug-supplying system
Body passage side view is as shown in figure 9, microfluidic channel is by inputting check valve, output one-way valve, Micropump, microfluidic networks access section
Divide and constitute.
Input check valve is by microfluid outfan 16, microfluid input 19, microfluid outfan cut-off passage 17, miniflow
Body input cut-off passage 18, microfluid communication passage 26, every liquid film 29, form every liquid film aperture 23.Microfluid outfan 16
With the check valve of microfluid input 19 and the miscellaneous part interface of microfluidic channel.Microfluid outfan cut-off passage 17, micro-
Fluid input cut-off passage 18 is connected with microfluid outfan 16 and microfluid input 19 respectively, microfluid communication passage 26
And microfluid outfan separates passage 17, input separate accompany between passage 18 one layer flexible every liquid film 29, every liquid film 29
The upper side leaning on microfluid outfan to separate passage 17 is left every liquid film aperture 23, for realizing the unidirectional input of air and liquid
Output function.
Output one-way valve is by microfluid outfan 11, microfluid input 14, microfluid outfan cut-off passage 12, miniflow
Body input cut-off passage 13, microfluid communication passage 27, every liquid film 30, form every liquid film aperture 21.Microfluid outfan 11
With the check valve of microfluid input 14 and the miscellaneous part interface of microfluidic channel.Microfluid outfan cut-off passage 12, micro-
Fluid input cut-off passage 13 is connected with microfluid outfan 11 and microfluid input 14 respectively, microfluid communication passage 27
And microfluid outfan separates passage 12, microfluid input separate accompany between passage 13 one layer flexible every liquid film 29, every
Lean on the side that microfluid outfan separates passage 12 to leave every liquid film aperture 21 on liquid film 30, realize the unidirectional defeated of air and liquid
Enter output function.
Microfluidic networks access part accesses passage 10 by microfluidic networks and constitutes, and microfluidic networks access partly to be responsible for even
Connect microfluidic channel and microfluidic networks.
Micropump accesses storehouse 15, Micropump coupling part 23 and Micropump coupling part 25 by Micropump medicine holding bin 5, Micropump, and Micropump is even
Socket part divide 23 and Micropump coupling part 25 Micropump medicine holding bin 5 and Micropump are accessed storehouse 15 and couple together that to be combined into Micropump overall.Micro-
Pump is accessed storehouse 15 and is connected with the microfluid outfan 16 of input check valve, the microfluid input 14 of output one-way valve.Micropump stores up
Medicine storehouse 5 storage medicinal liquid or air.
Non-return valve operational principle is as follows：
Taking input check valve as a example, when microfluid outfan 16 formation low pressure microfluid input 19 forms high pressure, gas
Or liquid is by by, under the ordering about of high pressure, entering microfluid input cut-off passage 18 from microfluid input 19.Due to pressure
Extruding is made it deform every liquid film 29 by poor presence by force, gas or liquid, leads to separate passage every the not closely connected input of liquid film 29
18 and produce slot, input separates gas in passage 18 or liquid can enter microfluid communication passage 26 by slot, and leads to
Cross and enter outfan cut-off passage 17 every liquid film aperture 23, eventually enter into microfluid outfan 16 it is achieved that check valve controls gas
Body or liquid flow to the function of outfan by input；And work as microfluid outfan 16 and form high pressure and microfluid input 19 shape
When becoming low pressure, gas or liquid are by by, under the ordering about of high pressure, entering microfluid outfan cut-off from microfluid outfan 16
Passage 17, and by flowing into microfluid communication passage 26 every liquid film aperture 23 on liquid film 29, extruding is another every liquid film 29
End, is allowed to be close to input cut-off passage 18, stops gas or liquid from flowing into input cut-off passage 18, therefore, in check valve
Gas or liquid reversely can not flow to input from outfan.
Microfluidic channel operation principle is as follows：
As shown in Figure 10, in the stage 1, pressing Micropump for the first time, Micropump produces deformation so that the microfluid of input check valve is defeated
Go out end 16 and the microfluid input 14 of output one-way valve is in relatively high pressure state, the microfluid input 19 of input check valve
It is in relatively low pressure state with the microfluid outfan 11 of output one-way valve.Therefore, the medicinal liquid in Micropump can be by output one-way valve
Microfluid input 14 flow to microfluid input 11, and miniflow can not be flowed to by the microfluid outfan 16 of input check valve
Body input 19, in Micropump, the medicinal liquid of storage exports microfluidic networks by output one-way valve, completes loading process.
As shown in figure 11, in the stage 2, when unclasping Micropump, the Micropump being extruded restores so that inputting the miniflow of check valve
The microfluid input 14 of body outfan 16 and output one-way valve is in relatively low pressure state, the microfluid input of input check valve
The microfluid outfan 11 of end 19 and output one-way valve is in relatively high pressure state.Therefore, the medicinal liquid in extraneous powder charge pond can pass through
The microfluid input 19 of input check valve flows to microfluid input 16, and inputs in the microfluid outfan 11 of check valve
Air can not be countercurrently to microfluid input 14.The medicinal liquid in extraneous powder charge pond passes through to input check valve entrance Micropump, completes powder charge
Process.
As shown in figure 12, in the stage 3, press Micropump again, Micropump produces deformation so that inputting the microfluid of check valve
The microfluid input 14 of outfan 16 and output one-way valve is in relatively high pressure state, the microfluid input of input check valve
19 and the microfluid outfan 11 of output one-way valve be in relatively low pressure state.Therefore, the medicinal liquid in Micropump can be unidirectional by exporting
The microfluid input 14 of valve flows to microfluid input 11, and can not be flowed to micro- by the microfluid outfan 16 of input check valve
Fluid input 19, in Micropump, the medicinal liquid of storage exports microfluidic networks by output one-way valve, completes loading process.
User's Micropump to described micropin drug-supplying system repeatedly is pressed and is unclasped operation, repeatable realize powder charge and
Loading process.
Although to the present invention, illustrative specific embodiment is described above, in order to the technology of the art
Personnel understand the present invention, the common skill it should be apparent that the invention is not restricted to the scope of specific embodiment, to the art
For art personnel, as long as various change is in the spirit and scope of the present invention of appended claim restriction and determination, these
Change is it will be apparent that all utilize the innovation and creation of present inventive concept all in the row of protection.
Claims (10)
1. one kind of the present invention pressure-controlled flexibility micropin drug-supplying system includes one and does not carry medicine solid array of microneedles, and its feature exists
In：Described micropin drug-supplying system incorporates microfluidic networks and microfluidic channel.
2. one kind according to claim 1 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：It is described that not carry medicine solid
Microneedle array is born photoresist by SU-8 and is made.
3. one kind according to claim 1 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：It is described that not carry medicine solid
Microneedle array be one be no less than 5 × 5 do not carry medicine solid array of microneedles.
4. one kind according to claim 1 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：Described microfluidic networks
It is made up of polydimethylsiloxane.
5. one kind according to claim 1 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：Described microfluidic networks
It is made up of one group of symmetrical microfluidic networks branch, microfluidic networks each branch leaves opening in top, and opening uniformly divides
In the bottom of described microneedle array, each branch of microfluidic networks is connected cloth with microfluidic channel.
6. one kind according to claim 1 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：Described microfluidic channel
It is made up of polydimethylsiloxane.
7. one kind according to claim 1 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：Described microfluidic channel
Access part including Micropump, check valve and microfluidic networks.
8. the one kind according to claim 1 or 7 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：Described Micropump dress
Carrier fluid body or gas, are connected with check valve.
9. the one kind according to claim 1 or 7 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：Described check valve
Including input check valve and output one-way valve, input one-way valved outlet is connected with Micropump, output one-way valve entrance and Micropump phase
Even, output one-way valve outlet microfluidic volume grid access section split-phase connects.
10. the one kind according to claim 1 or 7 pressure-controlled flexibility micropin drug-supplying system it is characterised in that：Described microfluid
Network insertion part is connected with microfluidic channel and microfluidic networks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610855409.0A CN106390277A (en) | 2016-09-28 | 2016-09-28 | Pressure-controlled flexible microneedle drug delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN109718462A (en) * | 2017-10-27 | 2019-05-07 | 研能科技股份有限公司 | The liquid feed device of human insulin injection |
| CN109805940A (en) * | 2017-11-20 | 2019-05-28 | 研能科技股份有限公司 | Blood sugar monitoring and control system |
| US11534587B2 (en) | 2017-11-20 | 2022-12-27 | Microjet Technology Co., Ltd. | Blood glucose monitoring and controlling system |
| WO2023060365A1 (en) * | 2021-10-15 | 2023-04-20 | Uti Limited Partnership | Microneedle and array and method of fabricating same |
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