CN106389962A - Traditional Chinese medicinal composition for preventing and treating lamb colibacillosis, and preparation method and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating lamb colibacillosis, which is prepared from the following components in parts by weight: 200±20 parts of Pulsatilla chinensis; 100±10 parts of dandelion; 100±10 parts of purslane; 180±10 parts of evodia ; Poppy shell 100 ± 10 parts; Schisandra 60 ± 5 parts; Jiao Sanxian 100 ± 10 parts; Poria cocos 100 ± 10 parts; The invention also provides its preparation method and application. The advantages and beneficial effects of the present invention are as follows: 1. The present invention adopts traditional Chinese medicine veterinary medicine, adopts pure Chinese medicine components, and takes the following Chinese medicines orally. After eating, lambs are cured quickly without side effects, which is beneficial to the growth of lambs. 2. The traditional Chinese medicine liquid of the present invention is simple to prepare, easy to use, low in cost of raw materials, has no toxic reaction after use, has a high cure rate, and has no residue. It is an ideal medicine for preventing and treating lamb colibacillosis.

Description

A traditional Chinese medicine composition for preventing and treating lamb colibacillosis and its preparation method and application

technical field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating lamb colibacillosis, a preparation method and application thereof.

Background technique

Lamb colibacillosis, also known as lamb colibacillary diarrhea or lamb pullorum, is an acute infectious disease caused by Escherichia coli. The occurrence of the disease is related to factors such as poor climate environment, insufficient nutrition, damp sheep house, and poor sanitation environment. The disease is most likely to occur during winter and spring house feeding. Usually, the resistance of lambs due to this cause is reduced, and they lick contaminated ewe teats, utensils, objects, etc., and the germs reach the intestinal tract through the stomach, multiplying in large quantities in the intestinal tract, causing a large amount of intestinal fluid to accumulate, expanding the intestinal cavity, and stimulating intestinal peristalsis , causing diarrhea and eventually death due to dehydration, acidosis and disturbance of electrolyte balance.

The affected lambs were initially depressed, with obvious loss of appetite, conjunctival flushing, abdominal distension, teeth grinding, and moaning. After that, the thin feces are yellow and pasty, with mucus, blood or pus in the feces of individual sick sheep, and intestinal mucosa in the feces of severe cases. Most of the sick sheep with diarrhea symptoms have edema in the tail and some ear edema. Clinically, it is often divided into two syndrome types: septicemia type and enteritis type (also known as diarrhea type).

Septic blood type: usually occurs in lambs aged 2 to 3 weeks. The sick sheep manifested as lack of energy, weakness, lethargy, foamy mouth, mucus from the nose, mild diarrhea symptoms, and a rise in body temperature of 41°C to 42°C. With the development of the disease, symptoms of cranial nerves, visual impairment, blind walking, head bending to one side, staggering gait and other behaviors gradually appear. The sick sheep usually die within 2 days or a few days after the onset of the disease.

Enteritis type (also known as diarrhea type): it mostly occurs in newborn lambs aged 2 to 8 days. The body temperature of sick sheep often rises to about 41°C at the beginning, and the body temperature will gradually drop to normal after diarrhea occurs. Feces like feces, sometimes bloodshot and foamy, usually sick lambs are anal incontinent, contaminate the hindquarters and legs, and are extremely painful when defecating. When lambs show severe dehydration symptoms, they usually die within 1 to 3 days.

The disease seriously affects the growth and development of lambs. Therefore, in production practice, the prevention and treatment of lamb colibacillosis should be regarded as the top priority of sheep disease control. Lamb colibacillosis is currently mainly treated with antibiotics clinically. Although antibiotics can inhibit or kill many pathogenic E. coli, there are a large number of non-pathogenic bacteria in the intestinal tract of the body in addition to pathogenic E. coli. It plays a very important role in the normal metabolism of the body. Blind use of antibiotics will also inhibit or kill many non-pathogenic bacteria and destroy their composition, seriously affecting the digestive function of the body and aggravating the disease; develop drug resistance. The wanton abuse of chemical drugs, antibiotics and monomeric drugs not only produces many drug-induced diseases such as multidrug resistance and receptor hypersensitivity, but also causes pollution of livestock and poultry products, endangering human food hygiene and safety. Traditional Chinese medicine is derived from animals, plants and minerals, and contains a variety of biologically active ingredients. Most of them are made of natural plants. They are rich in resources, easy to obtain, good in effect, low in price, have minimal toxic and side effects, almost no residue, and no antibiotics. Medicinal properties, do not pollute the environment. Therefore, it is particularly important to select traditional Chinese medicine preparations to replace chemical medicines and antibiotics.

Contents of the invention

The technical problem to be solved in the present invention is to overcome the existing defects, and to provide a traditional Chinese medicine composition for preventing and treating lamb colibacillosis with high cure rate, low toxicity and side effects, and resistance to drug resistance; the present invention also provides its preparation method and application.

The first object of the present invention is to provide a traditional Chinese medicine composition for preventing and treating lamb colibacillosis, which is prepared from the following components by weight: 200 ± 20 parts of Pulsatillae; 100 ± 10 parts of dandelion; 100 ± 10 parts of purslane Evodia 180±10 parts; Poppy shell 100±10 parts; Schisandra 60±5 parts; Jiao Sanxian 100±10 parts; Poria 100±10 parts;

Preferably, it is prepared from the following components by weight: 200±10 parts of Pulsatilla chinensis; 100±5 parts of dandelion; 100±5 parts of purslane; 180±5 parts of Evodia rutaecarpa; 100±5 parts of poppy shell; 100±5 parts of Jiao Sanxian; 100±5 parts of Poria cocos; 60±2 parts of roasted licorice.

Most preferably, the preparation is completed by the following components by weight: 200 parts of Pulsatilla chinensis; 100 parts of dandelion; 100 parts of purslane; 180 parts of Evodia rutaecarpa; 100 parts of poppy shell; 60 parts of licorice.

Under the above-mentioned optimal conditions, the control effect of the obtained traditional Chinese medicine composition is gradually improved. The control effect is the best under the most optimal conditions.

The second object of the present invention is to provide a preparation method of the above-mentioned traditional Chinese medicine composition, which is prepared by mixing the components in the formula amount, firstly extracting with water and then extracting with alcohol.

As a preference, the specific preparation method is: after mixing the components of the formula amount, add 8-12 times the weight of the medicinal material in water, decoct twice, each time for 90-120 minutes, combine the decoction, filter, and let the filtrate stand Take the supernatant, concentrate it to a relative density of 1.00-1.10, add ethanol to an alcohol content of 70-75%, place it, filter it, recover the ethanol, add water to a relative density of 1.00-1.10, and sterilize it; as a preference, alcohol After extracting and adding water to a relative density of 1.00-1.10, add an antifungal agent, such as adding calcium propionate 2g/kg liquid or potassium sorbate 2g/kg liquid.

The third object of the present invention is to provide the application of the above-mentioned traditional Chinese medicine composition in the preparation of medicaments for preventing and/or treating lamb colibacillosis.

The fourth object of the present invention is to provide a medicine whose active ingredient is the above-mentioned traditional Chinese medicine composition.

Preferably, the medicament also includes medically acceptable auxiliary materials.

Preferably, the dosage form of the medicine is oral liquid.

Preferably, the method of using the drug is: therapeutic dose: lamb, 1-3ml/kg·BW, 1 time/d, consecutively for 5-7 days; preventive dose: lamb, 2ml/kg·BW, 1 time/d , Use continuously for 5-7 days.

Lamb diarrhea mostly occurs in autumn, winter and spring. Lambs have weak spleen and stomach, weak transport and transformation functions, and most of them have greed for cold and eat rotten food. Sincerely. Traditional Chinese veterinary medicine believes that the occurrence of this disease is mainly due to (1) the lamb is young, the spleen and stomach are weak, the transportation and transformation function is not strong, and it cannot absorb water and grains and the essence of transportation and transformation. . As it is said in "Jingyue Quanshu • Diarrhea": "The root of diarrhea is all due to the spleen and stomach". (2) Feel the evils of the season: In autumn and winter, damp evils are transpiring. If the adjustment is not appropriate, you feel the air of cold, damp, filthy, turbid and pestilence, or because you sleep in the open, the invasion of cold and damp, guest evils and foul air, and depression in the middle burner, you can all feel it. The spleen and stomach are injured, the transportation and transformation are abnormal, the movement of qi is unfavorable, the ascending and descending is lost, the turbidity is related, and the intestines and stomach are disordered to cause diarrhea. (3) Unclean feeding: Unclean feeding, rotten and degenerated food by mistake, or cold and cold feed can most damage the spleen and stomach, and it is formed by mixing turbidity and turbidity.

To sum up, the disease is mainly due to the delicate viscera and viscera of the lamb, the lack of physical energy or congenital dysplasia, and the lack of acquired nutrition, which leads to the weakness of the spleen and stomach and the decline of resistance of the lamb. Spleen and stomach, dampness and poison trap the spleen, deficiency of spleen and stomach qi, and stagnation of yang in the middle, resulting in stagnation of qi movement, ups and downs and disorder, the spleen governs movement and transformation and raises clear yang, stomach governs acceptance and lowers turbid yin, now there is cold in the middle of the deficiency, and the rise and fall Dereliction of duty, so it is abdominal pain in the lower abdomen, and no desire to eat or drink; the digestion and absorption function of the spleen and stomach is disturbed, clear and turbid are mixed and descended, damp and hot are forced down, the large and small intestines are not secreted, and water and dampness cannot be divided, resulting in diarrhea, so feces Thin, fishy, or stagnant in the intestines, causing intestinal qi and blood to block and turn into white pus, so the diarrhea is white or white with pus. It is suitable for clearing away heat and detoxification, promoting blood circulation and stopping dysentery, astringent and astringent, invigorating the spleen and removing dampness, harmonizing the stomach and stopping diarrhea.

The medicine of the present invention is to clear away heat and dampness with Pulsatilla grandis, cool blood and detoxify, dandelion clears heat and detoxifies, reduces swelling and dissipates stagnation, and the two medicines are the king medicines for treating this syndrome. Purslane has the effect of clearing heat and detoxifying, dissipating blood and reducing swelling, and can cure dysentery and pus and blood; poppy shell astringent intestines to stop diarrhea and relieve pain; Dispelling dampness, promoting qi and promoting digestion, invigorating the spleen and whetting the appetite, Poria cocos invigorating the spleen, transporting dampness and stopping diarrhea, the above five medicines are ministerial medicines altogether. Evodia rutaecarpa is pungent, warms and dispels cold, warms the liver and stomach, and prevents the disadvantages of the bitter cold medicine from defeating the stomach and injuring the yang, and it is an anti-adjuvant. Roasted Glycyrrhiza invigorates the Qi, harmonizes the urgency, can detoxify the poison of various medicines, and alleviate the pungent nature of the medicines. When all medicines are used together, both symptoms and root causes can be treated, and the righteous qi will be unobstructed, and the evil will be eliminated by itself.

The medicine of the present invention is concentrated from traditional Chinese medicines such as pulsatilla, dandelion, purslane, poppy husk, etc., to invigorate the spleen and eliminate dampness, harmonize the stomach and detoxify the root cause, promote blood flow and stop dysentery, astringe and astringe, harmonize the stomach and relieve diarrhea to treat lamb colibacillosis the goal of. The formula fully refers to the eight principles of veterinary medicine and the theory of syndrome differentiation of viscera and viscera, taking into account both the exterior and the interior, treating qi and blood at the same time, precise and specialized medicine, and strict compatibility.

Modern veterinary pharmacological research and long-term clinical practice have proved that traditional Chinese medicine has the advantages of high overall curative effect, low drug resistance, low residue, and small toxic and side effects. It has a significant inhibitory effect on the growth and reproduction of many bacterial pathogens, even reaching The pharmacological effect of killing pathogens. According to the etiology, pathogenesis, clinical pathology and drug action mechanism of lamb colibacillosis, the present invention carries out the prevention and treatment of lamb colibacillosis with traditional Chinese medicine compound, and develops a Chinese medicine compound preparation with remarkable curative effect, reliable quality, convenient application and low price, and It is of great economic and social significance to promote the healthy development of sheep raising industry in sheep raising production.

The advantages and beneficial effects of the present invention are as follows: 1. The present invention adopts traditional Chinese medicine veterinary medicine, adopts pure Chinese medicine components, and takes the following Chinese medicines orally. After eating, lambs are cured quickly without side effects, which is beneficial to the growth of lambs. 2. The traditional Chinese medicine liquid of the present invention is simple to prepare, easy to use, low in cost of raw materials, has no toxic reaction after use, has a high cure rate, and has no residue. It is an ideal medicine for preventing and treating lamb colibacillosis.

The medicament of the present invention can be directly fed to lambs when it is specifically used.

The dosage of the medicine of the present invention is: therapeutic dose: lamb, 1-3ml/kg·BW (optimally 2ml/kg·BW), 1 time/d, continuous use for 5-7 days; preventive dose: lamb, 2ml/kg·BW kg·BW, 1 time/d, consecutively for 7 days.

detailed description

The following examples facilitate a better understanding of the present invention, but do not limit the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the following examples are commercially available unless otherwise specified.

A kind of traditional Chinese medicine composition for preventing and treating lamb colibacillosis of the present invention is prepared from the following components by weight:

Pulsatilla 200±20 parts; Dandelion 100±10 parts; Purslane 100±10 parts; Evodia 180±10 parts; Poppy husk 100±10 parts; 60 ± 5 parts of roasted licorice.

The preparation method of the Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention may further comprise the steps:

Take each component in parts by weight, add water with 8-12 times the weight of the medicinal material, decoct twice, 90-120 minutes each time, combine the decoction, filter, leave the filtrate for 12 hours, take the supernatant and concentrate to The relative density is 1.00-1.10, add ethanol to the alcohol content of 70-75%, place, filter, recover ethanol, add water to the relative density of 1.00-1.10, add calcium propionate 2g/kg liquid or potassium sorbate 2g/ kg of liquid medicine, mixed evenly, cooled for 24 hours, filtered and divided into brown sterile polyester bottles, and steamed at 100°C for 50-60 minutes to obtain the product.

The dosage of the medicine of the present invention is: therapeutic dose: lamb, 1-3ml/kg·BW (optimally 2ml/kg·BW), 1 time/d, continuous use for 5-7 days; preventive dose: lamb, 2ml/kg·BW kg·BW, 1 time/d, consecutively for 7 days.

The traditional Chinese medicine composition prepared within the above range can effectively prevent and treat lamb colibacillosis. Under the above-mentioned dosage and taking time, the cure rate of the high dose (3ml/kg·BW) is above 88.4%, and the medium dose ( 2ml/kg·BW) the cure rate is above 85.6%, and the cure rate of the low dose (1ml/kg·BW) is above 71.3%. The incidence rate of the disease is less than 5%, and the cure rate of the prevention group is above 84% after treatment is given after the onset.

Below are several preferred embodiments, wherein the therapeutic effect of the Chinese medicine preparation prepared in Example 1 is the best.

Example 1

The formula of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is as follows:

Pulsatilla 200g; Dandelion 100g; Purslane 100g; Evodia 180g; Poppy shell 100g; Schisandra 60g; Jiao Sanxian 100g;

The preparation method of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is:

Weigh each component of the formula amount, add 8 times the weight of the medicinal material, decoct twice, 90 minutes each time, combine the decoction, filter, let the filtrate stand for 12 hours, take the supernatant and concentrate to a relative density of 1.05 , add ethanol to 70% alcohol content, place, filter, recover ethanol, add water to a relative density of 1.05, add calcium propionate 2g/kg liquid, mix well, cool for 24 hours, filter with a brown sterile polyester bottle Subpackaged, steamed at 100°C for 50 minutes, ready to serve.

Example 2

The formula of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is as follows:

Pulsatilla 210g; Dandelion 95g; Purslane 95g; Evodia 185g; Poppy shell 95g;

The preparation method of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is:

Take each component in parts by weight, add water 10 times the weight of the medicinal material, decoct twice, 100 minutes each time, combine the decoction, filter, let the filtrate stand for 12 hours, take the supernatant and concentrate to a relative density of 1.00 , add ethanol to 75% alcohol content, place, filter, recover ethanol, add water to a relative density of 1.00, add potassium sorbate 2g/kg liquid, mix well, cool for 24 hours, filter with a brown sterile polyester bottle Subpackaged, steamed at 100°C for 60 minutes, ready to serve.

Example 3

The formula of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is as follows:

Pulsatilla 190g; Dandelion 105g; Purslane 105g; Evodia 175g; Poppy shell 105g;

The preparation method of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is:

Take each component in parts by weight, add water with 12 times the weight of the medicinal material, decoct twice for 120 minutes each time, combine the decoction, filter, let the filtrate stand for 12 hours, take the supernatant and concentrate to a relative density of 1.10 , add ethanol to 72% alcohol content, place, filter, recover ethanol, add water to a relative density of 1.10, add calcium propionate 2g/kg liquid, mix well, cool for 24 hours, filter with a brown sterile polyester bottle Subpackaged, steamed at 100°C for 50 minutes, ready to serve.

Example 4

The formula of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is as follows:

Pulsatilla 180g; Dandelion 110g; Purslane 110g; Evodia 170g; Poppy shell 90g;

The preparation method of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is:

Take each component in parts by weight, add water 10 times the weight of the medicinal material, decoct twice, 110 minutes each time, combine the decoction, filter, let the filtrate stand for 12 hours, take the supernatant and concentrate to a relative density of 1.05 , add ethanol to 72% alcohol content, place, filter, recover ethanol, add water to a relative density of 1.00, add potassium sorbate 2g/kg liquid, mix well, cool for 24 hours, filter with a brown sterile polyester bottle Dispense, and circulate steam at 100°C for 52 minutes to obtain the product.

Example 5

The formula of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is as follows:

Pulsatilla 220g; Dandelion 90g; Purslane 90g; Evodia 190g; Poppy shell 110g;

The preparation method of a kind of Chinese medicine composition of preventing and treating lamb colibacillosis of the present invention is:

Take each component according to parts by weight, add 11 times the weight of the medicinal materials, decoct twice, 100 minutes each time, combine the decoction, filter, let the filtrate stand for 12 hours, take the supernatant and concentrate to a relative density of 1.10 , add ethanol to 70% alcohol content, place, filter, recover ethanol, add water to a relative density of 1.10, add calcium propionate 2g/kg liquid, mix well, cool for 24 hours, filter with a brown sterile polyester bottle Subpackaged, steamed at 100°C for 60 minutes, ready to serve.

Example 6 Application Example

1) Treatment trials:

The applicant has carried out a randomized double-blind test method to treat natural lamb colibacillosis with different doses, and selected colistin sulfate injection as the positive drug control group. Observe the therapeutic effect of the present invention on lamb colibacillosis, so as to explore the feasibility of its application in livestock and poultry production.

Therapeutic test on naturally occurring lamb colibacillosis: the naturally occurring diseased lambs diagnosed as lamb colibacillosis through clinical diagnosis and laboratory diagnosis were randomly divided into 5 groups, 36 in each group. Group 1-3 is the drug treatment group prepared by Example 1 of the present invention (three groups of high, medium and low doses are set up respectively); the 4th group is the positive drug control group of colistin sulfate injection; the 5th group is Positive control group (infection, no administration). They were kept in isolation, and the symptoms, cure, and death of the sick lambs were recorded in detail.

Dosing method, medication time: medicine 1 group: each lamb is fed with 3ml/kg·BW of the medicine prepared in Example 1 of the present invention each time, once a day, and fed continuously for 7 days; medicine 2 groups: each lamb is fed every time Feeding 2ml/kg BW of the medicine prepared in Example 1 of the present invention once a day for 7 days; 3 groups of medicine: each lamb was fed with 1ml/kg BW of the medicine prepared in Example 1 of the present invention each time, Once a day, even for 7 days. Positive drug control group: each lamb was given colistin sulfate injection (according to the instructions) every day for 7 consecutive days; positive control group: no administration.

Experimental results:

After the treatment group fed the drug for 24 hours, the spirit of the diseased lambs in the drug group was better than that of the positive control group. After 36 hours, the number of deaths was counted, and the number of deaths of the diseased lambs in the drug group was significantly less than that of the positive control group; Things got better, but the positive control group still died one after another. After 3 days, the spirit and appetite of the sick lambs in the drug group were greatly improved (as seen from the increase in the amount of milk and feed), and the feces were normal. After 5 days, the sick lambs in the drug group returned to normal.

The statistical results of the test show that among the 36 lambs of the high-dose treatment group of the present invention, 32 were cured, and 4 were still loose, but did not die, and the cure rate was 88.9%; among the 36 lambs of the middle-dose treatment group, 31 were fully recovered. 5 lambs still had diarrhea, but no death, the cure rate was 86.1%; among the 36 lambs in the low-dose treatment group, 26 lambs were cured, 8 lambs were still diarrhea, and 2 died, the cure rate was 72.2%; colistin sulfate injection Of the 36 lambs in the treatment group (control group), 26 were cured, 5 were still diarrhea, and 5 died, the cure rate was 72.2%. Among the 36 lambs in the positive control group (no administration), 24 were still diarrhea. diarrhea, and 12 died. The death rate of the high and middle dose treatment groups is 0.0%, and the sick lambs of the treatment group are compared with the sick lambs of the control group, showing that the symptoms are alleviated, and the course of disease is shortened. Experiments prove that the high, middle and low doses of the present invention have a therapeutic effect on lamb colibacillosis , can relieve symptoms and reduce mortality, and high and medium doses are superior to colistin sulfate injection in reducing mortality and improving the cure rate. Both high and medium doses of the present invention can achieve the effect of curing diseases and improving the survival rate, and there is no difference between the two at the level of 0.05, so the medium dose can be used in clinical use, which is economical and effective.

2) Prevention test

In the sheep farm where the epidemic occurred, 120 healthy lambs without disease were randomly divided into 2 groups, 60 in each group, the first group was the drug prevention group; the second group was the control group; each lamb in the first group was fed daily The medicine 2ml/kg·BW that the embodiment 1 of the present invention prepares is fed continuously for 7 days; The 2nd group does not add any medicine; Other measures of two groups of lambs are all according to the normal disinfection and immunization procedure of the sheep farm.

The results showed that the incidence of colibacillosis in lambs in the drug prevention group was 3.0%, and that in the control group was 75.0%. The spirit and appetite of the lambs in the drug group were better than those in the control group, and the disease symptoms were lighter than those in the control group. After the prevention group was given treatment after the onset, the cure rate was 86.0%, while that of the control group was 67.0%.

From the test results, the present invention has the functions of replenishing qi, invigorating the spleen and removing dampness, strengthening the body and dispelling pathogenic factors, harmonizing the stomach and relieving diarrhea, astringent and astringent, detoxification and turbidity removal, dispelling cold and relieving pain. No adverse reactions were found in the drug during the clinical trials. High, medium and low doses have a good therapeutic effect on lamb colibacillosis. The therapeutic effect of the low-dose group was lower than that of the high-dose and middle-dose groups, and there was no significant difference in mortality, cure rate and total effective rate between the middle-dose and high-dose groups. According to the severity of the disease and the cost of treatment, it is recommended to use medium and high doses (lamb 10-15ml) for clinical application; preferably, it should be used continuously for 7 days (to ensure the curative effect).

The drug of the present invention is subjected to an accelerated test for 3 months under the condition of temperature: 40°C±2°C and relative humidity: 75%±5% according to the packaging conditions on the market, and the quality has no obvious change. In the long-term test for 24 months under the condition of temperature: 25℃±2℃ and relative humidity: 60%±10%, the quality has no obvious change. The above test results show that the medicine of the present invention is stable in storage quality under specified conditions.

Finally, it should be noted that: the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, it still The technical solutions recorded in the foregoing embodiments may be modified, or some technical features thereof may be equivalently replaced. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (10)

1. A traditional Chinese medicine composition for preventing and treating lamb colibacillosis, characterized in that: it is prepared from the following components by weight: 200 ± 20 parts of Pulsatilla chinensis; 100 ± 10 parts of dandelion; 100 ± 10 parts of purslane; 180 parts of Evodia rutaecarpa ±10 parts; Poppy shell 100±10 parts; Schisandra 60±5 parts; Jiao Sanxian 100±10 parts; Poria cocos 100±10 parts; 2. The traditional Chinese medicine composition according to claim 1, characterized in that: it is prepared from the following components in parts by weight: 200±10 parts of Pulsatilla chinensis; 100±5 parts of dandelion; 100±5 parts of purslane; 180±5 parts of Evodia rutaecarpa 5 parts; poppy shell 100±5 parts; schisandra 60±2 parts; Jiao Sanxian 100±5 parts; Poria 100±5 parts; 3. The traditional Chinese medicine composition according to claim 2, characterized in that: it is prepared from the following components by weight: 200 parts of Pulsatilla pulsatillae; 100 parts of dandelion; 100 parts of purslane; 180 parts of Evodia rutaecarpa; 100 parts of poppy shell; 60 parts of schisandra; 100 parts of Jiao Sanxian; 100 parts of Poria cocos; 60 parts of roasted licorice. 4. The preparation method of the traditional Chinese medicine composition according to any one of claims 1-3, which is characterized in that: it is prepared by mixing the components in the formula amount, firstly extracting with water and then extracting with alcohol. 5. The preparation method according to claim 4, characterized in that: the specific preparation method is: after mixing the components of the formula amount, add water with 8-12 times the weight of medicinal materials, decoct 2 times, each time 90- For 120 minutes, combine the decoctions, filter, let the filtrate stand still, take the supernatant, and concentrate to a relative density of 1.00-1.10, add ethanol to an alcohol content of 70-75%, let it stand, filter, recover ethanol, add water to a relative density of 1.00-1.10, it can be obtained by sterilization; as a preference, after alcohol extraction and adding water to a relative density of 1.00-1.10, add an antifungal agent, such as adding calcium propionate 2g/kg liquid or potassium sorbate 2g/kg liquid. 6. The application of the Chinese medicine composition described in any one of claims 1-3 in the preparation of the medicine for preventing and/or treating lamb colibacillosis. 7. A medicine, characterized in that: the active ingredient of the medicine is the traditional Chinese medicine composition according to any one of claims 1-3. 8. The medicine according to claim 7, characterized in that: said medicine also includes medically acceptable auxiliary materials. 9. The medicine according to claim 7 or 8, characterized in that: the dosage form of the medicine is oral liquid. 10. The drug according to claim 9, characterized in that: the method of using the drug is: therapeutic dose: lamb, 1-3ml/kg·BW, 1 time/d, continuous use for 5-7 days; preventive dose: Lamb, 2ml/kg·BW, 1 time/d, for 5-7 consecutive days.