CN106370584A - Blood corpuscle detection and biochemical detection instrument and detection method thereof - Google Patents
Blood corpuscle detection and biochemical detection instrument and detection method thereof Download PDFInfo
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- CN106370584A CN106370584A CN201610687366.XA CN201610687366A CN106370584A CN 106370584 A CN106370584 A CN 106370584A CN 201610687366 A CN201610687366 A CN 201610687366A CN 106370584 A CN106370584 A CN 106370584A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
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- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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Abstract
The invention discloses a blood corpuscle detection and biochemical detection instrument and a detection method thereof. The detection instrument comprises a transfer module, a dilution liquid addition module, a hemolytic agent addition module, a cleaning agent addition module, a first detection cup, a second detection cup, a cleaning module, a uniform mixing module and a control module. The first detection cup is used for first dilution of a blood sample, simultaneous detection of leucocyte and ferrohemoglobin indexes in the same blood sample and detection of the other one biochemical component in the blood sample. The second detection cup is used for second dilution of a blood sample and detection of erythrocyte and platelet in the dilute blood sample. The detection instrument realizes fast blood routine detection and other biochemical component detection through the same biochemical detection instrument, has complete functions, realizes fast clinical urgent blood routine detection and biochemical index detection, has low sample consumption, has simple operation processes and produces few wastes.
Description
Technical field
The invention belongs to medical test detection technique field, particularly a kind of hemocyte and bio-chemical detector and its detection side
Method.
Background technology
Often need laboratory to obtain blood samples of patients hemocyte detection information and biochemistry detection in medical clinic applicationses simultaneously
Information, the Integrated Checkout information that laboratory provides can provide more perfect tutorial message to clinical disease diagnosis and treatment.
Existing blood cell detection and biochemistry detection are usually entered respectively on blood analyser and biochemistry analyzer respectively
OK, two parts of blood samples must be prepared when therefore detecting and two different instrument sides can complete two types detection, operation is more numerous
Trivial, and due to usually needing manual delivery sample, sample encoded information easily makes a mistake in manual delivery, this detection pattern
The needs of the quick detections such as outpatient service, emergency treatment cannot be met.And the instrument detection of existing executable blood routine and biochemistry detection
Project is single, and structure is more complicated, and flow process is cumbersome.
Content of the invention
It is an object of the invention to provide a kind of hemocyte and bio-chemical detector and its detection method.
The technical scheme realizing the object of the invention is: a kind of hemocyte and bio-chemical detector, and this detector includes shifting mould
Block, hemolytic agent add module, diluent add module, abluent add module, the first detection cup, the second detection cup, cleaning mould
Block, mixing module and control module；
Described shift module is used for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle,
First liquid draw-out device and a mobile device；Described mobile device be used for driving suction needle sample position, biochemical reagents position,
Move between first detection cup, the second detection cup；
Described hemolytic agent add module includes a hemolytic agent position and second liquid draw-out device, for the first detection cup
Middle interpolation hemolytic agent；
Described diluent add module includes a dilution liquid level and the 3rd liquid extracting device, for the first detection cup
Add diluent with the second detection cup；
Described abluent add module includes an abluent position and the 4th liquid extracting device, for the first detection cup
Middle interpolation abluent；
Described first detection cup is used for blood sample being carried out dilute for the first time, and the first detection cup wall of cup is provided with the first granule
Counting and detecting device and transmission optical detection device, described first grain count detection means is used for leukocyte in the first detection cup
Granule is detected, described transmission optical detection device is used for hemoglobin in the first detection cup being detected and giving birth to adding
Change the blood sample after reagent and carry out biochemical project detection.
Described second detection cup is used for accepting the dilution blood sample being come by the first detection cup transfer, and carries out second dilution,
It is provided with the second grain count detection means, for red thin in sample in cup after second is diluted on second detection cup wall of cup
Born of the same parents and platelet are detected；
Described cleaning module includes suction needle washer, waste liquid discharge pipe and waste drains pump, and described suction needle washer is used
In cleaning suction needle outer wall, described waste liquid discharge pipe is used for discharging waste liquid in detection cup, and produces after the cleaning of suction needle washer
Waste liquid, described waste drains pump be waste liquid discharge provide power；
Described mixing module is passed through, to first, second detection cup bottom air-blowing, to carry out agitation to the liquid in detection cup mixed
Even；
Described control module is added in order to control shift module, diluent add module, hemolytic agent add module, abluent
Module, cleaning module, mix detection means work in module, the first detection cup and the second detection cup, and carry out detection data and divide
Analysis processes, shows, printing and output testing result.
A kind of hemocyte and the detection method of bio-chemical detector, comprise the following steps:
Step 1, draw whole blood sample by suction needle is quantitative from specimen cup, transfer in the first detection cup, diluent
Add module adds quantitative diluent in the first detection cup, and by mixing module to liquid blending in the first detection cup；
By suction needle washer, suction needle outer wall is carried out；
Step 2, by suction needle from first detection cup in draw quantitation dilution, mix after blood sample be transferred to the second inspection
Survey cup, diluent add module adds quantitative diluent in the second detection cup, and the blood sample being come with suction needle transfer is carried out
Dilution, by mixing module to liquid blending in the second detection cup, the second grain count detection means mixes in the second detection cup
Blood sample carries out erythrocyte and platelets analysis afterwards；By suction needle washer, suction needle outer wall is carried out；
Step 3, by hemolytic agent add module to first detection cup in add quantitative hemolytic agent and through mix module pair
Liquid blending in first detection cup, the first grain count detection means and transmission optical detection device are respectively to mixed in the first detection cup
Blood sample after even carries out white blood cell detection and hemoglobin detection；
Step 4, by suction needle movement to biochemical reagents position, draw quantitative biochemical reagents and be simultaneously transferred to the first detection cup,
Mix liquid in the first detection cup again, using transmission optical detection device, the dilute sample adding mixing after biochemical reagents is carried out
Detection, obtains the testing result of corresponding biochemical project.
Compared with prior art and product, the remarkable result of the present invention is: (1) present invention is using a whole blood sample one
Blood routine and biochemistry detection are rapidly completed on platform instrument, originally each independent detection process are merged and once completes, it is to avoid
The repetition of part flow process, can reduce sample, and save detection time and streamline operation；(2) present invention is by blood routine
Detection two distinct types of with biochemistry detection completes in a system, and the testing result being obtained can be very efficient and accurate
The true original encoded information unification with sample；(3) present invention, can more preferably, more completely by newly-designed correction formula
Due to different biochemicals, different distributions in blood plasma and cell may lead to using whole blood sample and plasma/serum sample foot
Testing result difference, the accuracy of testing result can meet Clinical Laboratory needs；(4) present invention is using only at one three points
Only increase a biochemical reagents position and a transmitted light/scattering optical detection device it is possible to once complete on the basis of class Hematometer
Protometrocyte and biochemical project test, population structure is simple, and waste liquid produced by detection is less, is conducive to environmental protection.
Brief description
Fig. 1-1 be sample position cs, the first biochemical reagents position r1, first detection cup c1 and second detection cup c2 between mutual
Position relationship schematic diagram and suction needle movement locus schematic diagram.
Fig. 1-2 be sample position cs, the first biochemical reagents position r1, the second biochemical reagents position r1 ', first detection cup c1 and second
Mutual alignment relation schematic diagram between detection cup c2 and suction needle movement locus schematic diagram.
Fig. 1-3 is sample position cs, mutual between the first detection cup c1, the second detection cup c2 and the first biochemical reagents position r1
Position relationship schematic diagram and suction needle movement locus schematic diagram.
Fig. 1-4 is sample position cs, the first detection cup c1, the second detection cup c2, the first biochemical reagents position r1 and second biochemistry
Mutual alignment relation schematic diagram between the r1 ' of reagent position and suction needle movement locus schematic diagram.
Fig. 1-5 is sample position cs, the first detection cup c1, the second detection cup c2, the first biochemical reagents position r1 and second biochemistry
Mutual alignment relation schematic diagram between the r1 ' of reagent position and suction needle movement in a curve track schematic diagram.
Fig. 2-1 is two detection cup schematic diagrams of the present invention, and in figure first detection cup is provided with two light sources and two optics
Detection means.
Optical filter f1, f2 and f3 that Fig. 2-2～2-5 is respectively three different wave lengths are arranged on the first inspection during diverse location
Survey cup top view.
Fig. 3-1 is two detection cup schematic diagrams of the present invention, and the wherein first detection cup is provided only with two light sources and a light
Learn detection means；Fig. 3-2 and Fig. 3-3 is respectively three optical filters and is arranged on top view during the first detection cup diverse location.
Fig. 4 is bio-chemical detector structural representation of the present invention.
Fig. 5 is the suction needle washer schematic diagram of the present invention.
Fig. 6 is that existing biochemical instruments detect crp results relevance analysis chart with analyser of the present invention.
Fig. 7 is that existing biochemical instruments detect hba1c results relevance analysis chart with analyser of the present invention.
Specific embodiment
A kind of hemocyte of the present invention and bio-chemical detector and its detection method, add mould including shift module, hemolytic agent
Block, diluent add module, abluent add module, the first detection cup, the second detection cup, cleaning module, mixing module and control
Molding block.
Described shift module is used for transfering reagent and sample, including biochemical reagents position, sample position, suction needle, first
Liquid extracting device, connecting line and a mobile device；Described mobile device is used for driving suction needle in sample position, biochemical examination
Agent position, first detection cup, second detection cup between move；
Described hemolytic agent add module includes a hemolytic agent position and second liquid draw-out device, for the first detection cup
Middle interpolation hemolytic agent；Described diluent add module includes a dilution liquid level and the 3rd liquid extracting device, for first
Add diluent in detection cup and the second detection cup；Described abluent add module includes an abluent position and the 4th liquid is taken out
Take device, for adding abluent in the first detection cup；
Described first detection cup is used for blood sample being carried out dilute for the first time, and the first detection cup wall of cup is provided with the first granule
Counting and detecting device and transmission optical detection device, the first grain count detection means is used for plasmasome in cup is examined
Survey, transmission optical detection device is used for hemoglobin is detected and carries out biochemical project to the blood sample after addition biochemical reagents
Detection；
Described second detection cup is used for accepting the dilution blood sample being come by the first detection cup transfer, and blood sample is carried out with second
Dilution, the second detection cup wall of cup is provided with the second grain count detection means, for erythrocyte in cup after second is diluted
Detected with platelet；
Described mixing module is passed through to first, second detection cup bottom air-blowing, and it is right that the aqueous agitation in detection cup is realized
Liquid blending in detection cup；
Described cleaning module includes suction needle washer, waste liquid discharge pipe and waste drains pump, and described suction needle washer is such as
Shown in Fig. 5, for cleaning suction needle outer wall, reduce cross-contamination, described waste liquid discharge pipe is used for waste liquid in exclusion detection cup, and
The waste liquid producing after the cleaning of suction needle washer, described waste drains pump is discharged for waste liquid and is provided power；
Described control module is added in order to control shift module, diluent add module, hemolytic agent add module, abluent
Module, cleaning module, mix detection means work in module, the first detection cup and the second detection cup, and carry out detection data and divide
Analysis processes, shows, printing and output testing result.
Further, described first detection cup wall of cup is additionally provided with scattering optical detection device, for examination biochemical to addition
Blood sample after agent carries out biochemical project detection.
Further, described scattering optical detection device and transmission optical detection device are Single wavelength detection means or multi-wavelength inspection
Survey device.Scattering optical detection device and transmission optical detection device need wavelength switching according to detection, and the switching of Detection wavelength is passed through
The monochromator device realization that wavelength can be changed is installed before toggle lights, switching voltage or detector.
Further, described shift module includes more than one biochemical reagents position.
Further, bio-chemical detector is additionally provided with the washer of a suction needle outer wall capable of washing.
Further, described first detection cup and the second detection cup surrounding are equipped with radome, set above described radome
Be equipped with opening, be provided with opening can automatic shutter lid, cover closing during detection, during sample-adding lid open.
Further, the first detection cup also has constant temperature and heater it is ensured that obtaining accurate biochemistry detection result.
The present invention also provides the detection method of a kind of hemocyte and bio-chemical detector, comprises the following steps:
Step 1, draw whole blood sample by suction needle is quantitative from specimen cup, transfer in the first detection cup, diluent
Add module adds quantitative diluent in the first detection cup, and by mixing module to liquid blending in the first detection cup；
By suction needle washer, suction needle outer wall is carried out；
Step 2, by suction needle from first detection cup in draw quantitation dilution, mix after blood sample be transferred to the second inspection
Survey cup, diluent add module adds quantitative diluent in the second detection cup, and the blood sample being come with suction needle transfer is carried out
Dilution, by mixing module to liquid blending in the second detection cup, the second grain count detection means mixes in the second detection cup
Blood sample carries out erythrocyte and platelets analysis afterwards；By suction needle washer, suction needle outer wall is carried out；
Step 3, by hemolytic agent add module to first detection cup in add quantitative hemolytic agent and through mix module pair
Liquid blending in first detection cup, the first grain count detection means and transmission optical detection device are respectively to mixed in the first detection cup
Blood sample after even carries out white blood cell detection and hemoglobin detection；
Step 4, by suction needle movement to biochemical reagents position, draw quantitative biochemical reagents and be simultaneously transferred to the first detection cup,
Mix liquid in the first detection cup again, using transmission optical detection device, the dilute sample adding mixing after biochemical reagents is carried out
Detection, obtains the testing result of corresponding biochemical project.
Further, replace transmission optical detection device to the biochemistry one-tenth in sample using scattering optical detection device in step 4
Part is detected, and obtains corresponding biochemical project testing result.
Further, the first grain count detection means and transmission optical detection device carry out leukocyte and hemoglobin respectively
After detection, add glycolated hemoglobin reagent in the first detection cup and mix, scattering optical detection device enters to liquid after mixing
Row glycolated hemoglobin detects, calculates glycolated hemoglobin according to hemoglobin testing result and glycolated hemoglobin testing result
Account for the ratio of hemoglobin.
For being mainly distributed on serum, blood plasma mesophytization ingredient analysis result, due to the knot obtaining during using whole blood test
Fruit has significant difference with using the testing result of serum or plasma sample, therefore, the instrument biochemistry to this some projects automatically
Item detection result be modified it is ensured that this instrument detection biochemical project result with using serum and blood plasma testing result one
Cause.Concrete correcting mode is:
Testing result is the concentration of certain biochemical component in unit volume plasma/serum, wherein serum/plasma volume=complete
Blood volume-blood cell volume, the wherein implication of "/" be or；The average body of platelet counts × platelet in cell volume=whole blood
The leukocyte average external volumes of quantity of leucocyte in erythrocyte number × mean corpuscular volume+whole blood in long-pending+whole blood × all × repair
The scope of positive divisor b, modifying factor a and b is respectively 0.3-4.0.
The volume of wherein leukocyte can also calculate according to equation below:
Leukocyte volume=big leukocyte average external volume × big quantity of leucocyte × modifying factor c+ SL volume ×
SL quantity × modifying factor d, the scope of modifying factor c and d is respectively 0.3-4.0；
Or the volume of wherein leukocyte can also calculate according to equation below:
Leukocyte volume=lymphocyte average external volume × lymphocyte quantity × modifying factor e+ neutrophilic granulocyte volume
× neutrophilic granulocyte quantity × modifying factor f+ intermediate cell volume × intermediate cell quantity × modifying factor g, modifying factor e, f
Scope with g is respectively 0.3--4.0.
But if requiring the testing result obtaining to be in certain biochemical content, rather than serum or blood plasma in whole blood
During the content of certain biochemical, then do not need to carry out above-mentioned correction to result.
In conjunction with Fig. 1-1～1-5, the sample position of detector, the first detection cup, the second detection cup, the first biochemical reagents position, the
Two biochemical reagents positions are all designed in suction needle motion track, and concrete layout is as follows:
As Figure 1-1: sample position cs → the first biochemical reagents position r1 → the first detection cup c1 → the second detection cup c2；
As shown in Figure 1-2: sample position cs → the first biochemical reagents position r1 → the second biochemical reagents position r1 ' → the first detection cup
C1 → the second detects cup c2；
As Figure 1-3: sample position cs → the first detection cup c1 → the second detection cup c2 → the first biochemical reagents position r1；
As shown in Fig. 1-4 and 1-5: sample position cs → the first detection cup c1 → the second detection cup c2 → the first biochemical reagents position
R1 → the second biochemical reagents position r1 '；
The invention will be further described with reference to the accompanying drawings and examples.
Embodiment 1
In conjunction with Fig. 1-1, Fig. 2-1 and Fig. 4, detection routine blood test and single reagent biochemical project in the present embodiment.
This detector include shift module, hemolytic agent add module, diluent add module, abluent add module,
One detection cup, the second detection cup, cleaning module, mixing module and control module；
During detection, suction needle n1 moves in specimen cup, and the second valve v2 closes, the first valve v1 opens, first liquid
Draw-out device s1 piston is pulled back, and quantitative sample sucks in suction needle n1, and mobile device drives suction needle n1 mobile to the first detection
Cup c1, the first valve v1 close, and the second valve v2 opens, and first liquid draw-out device s1 piston advances blood sample in suction needle n1
It is added in the first detection cup c1；In diluent add module, the 6th valve v6 opens, the second valve v2, the 13rd valve v13
Close with the 5th valve v5, the 3rd liquid extracting device s3 piston is pulled back and for diluent r3 to be sucked the 3rd liquid extracting device s3
In, the 6th valve v6 closes, the 13rd valve v13 opens, the 3rd liquid extracting device s3 piston propulsion, then former suction the 3rd liquid
Diluent in body draw-out device s3 enters the first detection cup c1 along n3；Mix the tenth valve v10 and the 12nd valve in module
V12 closes, and the 9th valve v9 and the 11st valve v11 opens, the air-blowing of air pump p1, drives gas to enter the first detection along pipeline
Cup c1 bottom, mixes liquid in cup.
Suction needle n1 draws the diluted sample after part mixes from the first detection cup c1, is transferred to the second detection cup c2,
In diluent add module, the 6th valve v6 opens, and the 5th valve v5, the second valve v2 and the 13rd valve v13 close, and the 3rd
Liquid extracting device s3 piston is pulled back and is drawn quantitative diluent r3, the 6th valve v6 and the 13rd valve v13 closing, the 5th valve
Door v5, the first valve v1 and the second valve v2 open, and the 3rd liquid extracting device s3 piston advances the 3rd liquid extracting device
Quantitative diluent in s3 passes through second diluent pin n3 ' injection the second detection cup c2, enters suction needle n1 by pipeline simultaneously,
It is carried out to inside suction needle n1.Mix the 9th valve v9 and the 12nd valve v12 in module to close, the tenth valve v10 and
11st valve v11 opens, the air-blowing of air pump p1, drives gas to enter the second detection cup c2 bottom along pipeline, mixes liquid in cup
Body.Second grain count detection means d5 is examined to the quantity of sample platelet and erythrocyte in the second detection cup c2 and volume
Survey.
The outer washer of pin is carried out to outside suction needle n1.4th valve v4 opens afterwards, and the 3rd valve v3 closes, the
Two liquid extracting device s2 pull back, and hemolytic agent r2 sucks in second liquid draw-out device s2, and the 4th valve v4 closes, the 3rd valve
V3 opens, and second liquid draw-out device s2 piston advances, and makes Quantitative Haemolytic agent enter the first detection cup c1.Mix the tenth in module
One valve v11 and the 9th valve v9 opens, and the tenth valve v10 and the 12nd valve v12 closes, the air-blowing of air pump p1, drive gas
Body enters the first detection cup c1 bottom along pipeline, mixes liquid in cup.D4 pair, first grain count device in first detection cup c1
In cup, quantity of leucocyte and volume are detected, the first transmitted light source l1 or the second transmitted light source l1 ' opens, the first transmitted light inspection
Survey device d1 or the second transmission optical detection device d1 ' content of hemoglobin is detected.
Suction needle n1 moves to the r1 of biochemical reagents position, and suction needle n1 gos deep into, in the r1 of biochemical reagents position, taking out in first liquid
Take under device s1, the first valve v1 and the second valve v2 cooperation, draw quantitative biochemical reagent by the r1 of biochemical reagents position, inhale afterwards
Sample pin n1 is mobile to add the first detection cup c1 to the first detection cup c1 place by biochemical reagents, mix in module the tenth valve v10 with
12nd valve v12 closes, and the 9th valve v9 and the 11st valve v11 opens, the air-blowing of air pump p1, drives gas to enter first
Detection cup c1 bottom, mixes liquid in cup.As Fig. 2-2,2-3,2-4 and 2-5, opened by the first transmitted light source l1, first is saturating
Penetrate optical detection device d1 detection optical signal transmissive, obtain single reagent biochemical project testing result.
After detection terminates, open the 9th valve v9, the tenth valve v10, the 12nd valve v12, waste drains pump p2 are evacuated, will be each
In the outer washer of detection cup, pin and pipeline, detection waste liquid enters in liquid waste collector；In abluent add module the 8th afterwards
Valve v8 opens, and the 7th valve v7 closes, and the 4th liquid extracting device s4 pulls back, and abluent r4 sucks the 4th liquid extracting device
S4, the 8th valve v8 closing afterwards, the 7th valve v7 opens, the 4th liquid extracting device s4 propulsion, in the first detection cup c1
Injection abluent r4, opens the 9th valve v9, the 12nd valve v12 afterwards, and waste drains pump p2 is evacuated, and cleaning waste liquid enters waste liquid and receives
Storage.The 6th valve v6 in diluent add module opens, and the 5th valve v5, the second valve v2 and the 13rd valve v13 close
Close, the 3rd liquid extracting device s3 piston is pulled back and drawn quantitative diluent r3, and the 6th valve v6 closes afterwards, the 5th valve
V5, the 13rd valve v13, the first valve v1 and the second valve v2 open, and the 3rd liquid extracting device s3 piston advances the 3rd
Quantitative diluent in liquid extracting device s3 passes through the first diluent pin n3 and the second diluent pin n3 ' injection the first detection cup
In c1 and second detection cup c2, suction needle n1 is entered by pipeline simultaneously, be carried out to inside each detection cup and suction needle n1.
Suction needle n1 now also executes pin exterior washings, and cleaning opens the 9th valve v9, the tenth valve v10, the 12nd valve after terminating
V12, waste drains pump p2 are evacuated, and cleaning waste liquid enters liquid waste collector.
In Fig. 4, suction needle n1, first liquid draw-out device s1, the first valve v1 and the second valve v2 constitute shift module；
Hemolytic agent pin n2, second liquid draw-out device s2, the 3rd valve v3 and the 4th valve v4 constitute hemolytic agent add module；Diluent
Pin n3 ' and n3, the 3rd liquid extracting device s3, the 5th valve v5, the 6th valve v6, the 13rd valve v13 constitute diluent and add
Plus module；Abluent pin n4, the 4th liquid extracting device s4, the 7th valve v7 and the 8th valve v8 constitute abluent and add mould
Block；Air pump p1, the 9th valve v9, the tenth valve v10, the 11st valve v11 and the 12nd valve v12 constitute mixing module.
Embodiment 2
In conjunction with Fig. 1-2, Fig. 2-1 and Fig. 4, the bio-chemical detector of the present embodiment is with the difference of embodiment 1, the present embodiment
Middle detection routine blood test and double reagent biochemical project, that is, the present embodiment include two biochemical reagents positions.
Suction needle n1 is mobile, and to the first biochemical reagents position r1, suction needle n1 gos deep in the first biochemical reagents position r1, the
Under one liquid extracting device s1, the first valve v1 and the second valve v2 cooperation, by drawing quantitative the in the first biochemical reagents position r1
One biochemical reagents, suction needle n1 is mobile afterwards adds the first detection cup c1 by the first biochemical reagents to the first detection cup c1, mixed
The tenth valve v10 in even module and the 12nd valve v12 closes, and the 9th valve v9 and the 11st valve v11 opens, air pump
P1 air-blowing, drives gas to enter the first detection cup c1 bottom, mixes liquid in cup.Suction needle n1 moves to the second biochemical examination afterwards
Agent position r1 ' place, draws quantitative second biochemical reagents according to the same manner and is transferred to the first detection cup c1, open the first transmitted light
Light source l1, the first transmission optical detection device d1 detection optical signal transmissive, obtain the testing result of double reagent biochemical project.
Embodiment 3
In conjunction with Fig. 3-1, the bio-chemical detector of the present embodiment is with the difference of embodiment 1, first detection of the present embodiment
First transmitted light source l1 and scattering light source l2 is provided with cup, and the first transmitted light source l1 and scattering light source l2 shares a detection
Device d3.First transmitted light source l1 is arranged on detection means d3 opposite, and scattering light source l2 and detection means d3 are in 30-120 ° of folder
Angle.
First transmitted light source l1 opens, and scattering light source l2 closes, and detection means d3 detects optical signal transmissive, obtains biochemical item
Mesh testing result.
Embodiment 4
The present embodiment is with the difference of embodiment 3, and scattering light source l2 opens, and the first transmitted light source l1 closes, detection dress
Put d3 detection scattered light signal, obtain biochemical project testing result.
Embodiment 5
The bio-chemical detector of the present embodiment is with the difference of embodiment 1 and 2, and the present embodiment passes through the second transmitted light source
L1 ' and the second transmission optical detection device d1 ' obtains biochemical project testing result.
Embodiment 6
In conjunction with Fig. 2-2～2-5 and Fig. 3-2～3-3, the present embodiment by using different wave length the first optical filter f1,
Two optical filter f2 and the 3rd optical filter f3, need to select specific wavelength according to detection in detection.
, the first optical filter f1 rotates to light source luminescent and in detection dress taking white oil by dual-wavelength method glycolated hemoglobin as a example
Before putting receiving area, set dominant wavelength 510nm, detection sample absorbance is a1；Second optical filter f2 rotates to light source and detection
In the middle of device, set commplementary wave length 600nm, detection sample absorbance is a2；Sample real absorbance aSample=a1-a2, by adopting
Double wave method detects, can effectively eliminate the impact to testing result for the interfering material in sample.
Embodiment 7
The present embodiment adopts existing biochemical instruments to detect 20 different samples from analyser of the present invention, and it is related to carry out result
Property compares, statistical data such as table 1.
The different sample of table 1 detects two kinds of biochemical results contrast with existing biochemical instruments with analyser of the present invention respectively
It is respectively adopted existing biochemical instruments from analyser of the present invention, 20 different samples to be detected, and carries out dependency and divide
Analysis, as shown in Figure 6 and Figure 7, Fig. 6 is crp testing result, and Fig. 7 is hba1c testing result, two kinds of distinct methods testing result phases
Guan Xing: rcrp=0.9974 >=0.95, rhba1C=0.9783 >=0.95, illustrates existing biochemical instruments and the detection of analyser of the present invention
Results relevance is good.
Claims (10)
1. a kind of hemocyte and bio-chemical detector it is characterised in that this detector include shift module, hemolytic agent add module,
Diluent add module, abluent add module, the first detection cup, the second detection cup, cleaning module, mixing module and control mould
Block；
Described shift module is used for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle, first
Liquid extracting device and a mobile device；Described mobile device be used for driving suction needle sample position, biochemical reagents position, first
Move between detection cup, the second detection cup；
Described hemolytic agent add module includes a hemolytic agent position and second liquid draw-out device, for adding in the first detection cup
Plus hemolytic agent；
Described diluent add module includes a dilution liquid level and the 3rd liquid extracting device, for the first detection cup and the
Add diluent in two detection cups；
Described abluent add module includes an abluent position and the 4th liquid extracting device, for adding in the first detection cup
Plus abluent；
Described first detection cup is used for blood sample being carried out dilute for the first time, and the first detection cup wall of cup is provided with the first grain count
Detection means and transmission optical detection device, described first grain count detection means is used for plasmasome in the first detection cup
Detected, described transmission optical detection device is used for hemoglobin in the first detection cup is detected and the biochemical examination to addition
Blood sample after agent carries out biochemical project detection.
Described second detection cup is used for accepting the dilution blood sample being come by the first detection cup transfer, and carries out second dilution, and second
Be provided with the second grain count detection means on detection cup wall of cup, for the erythrocyte in sample in cup after diluting to second and
Platelet is detected；
Described cleaning module includes suction needle washer, waste liquid discharge pipe and waste drains pump, and described suction needle washer is used for clear
Wash suction needle outer wall, described waste liquid discharge pipe is for giving up of producing after waste liquid in discharge detection cup and the cleaning of suction needle washer
Liquid, described waste drains pump is discharged for waste liquid and is provided power；
Described mixing module is passed through, to first, second detection cup bottom air-blowing, to carry out agitation to the liquid in detection cup and mix；
Described control module adds mould in order to control shift module, diluent add module, hemolytic agent add module, abluent
Detection means work in block, cleaning module, mixing module, the first detection cup and the second detection cup, and carry out detection data analysis
Process, show, printing and output testing result.
2. hemocyte according to claim 1 and bio-chemical detector are it is characterised in that also set up on the first detection cup wall of cup
There is scattering optical detection device, for biochemical project detection is carried out to the blood sample after addition biochemical reagents.
3. hemocyte according to claim 2 and bio-chemical detector are it is characterised in that described scattering optical detection device and thoroughly
Penetrating optical detection device is multi-wavelength detection device.
4. hemocyte according to claim 1 and bio-chemical detector are it is characterised in that bio-chemical detector also includes a use
Washer in cleaning suction needle outer wall.
5. hemocyte according to claim 1 and bio-chemical detector it is characterised in that described shift module include one with
On biochemical reagents position.
6. hemocyte according to claim 1 and bio-chemical detector are it is characterised in that described first detection cup periphery is arranged
There are constant temperature and heater.
7. a kind of detection method based on the hemocyte described in claim 1 and bio-chemical detector is it is characterised in that the method bag
Include following steps:
Step 1, draw whole blood sample by suction needle is quantitative from specimen cup, transfer in the first detection cup, diluent adds
Module adds quantitative diluent in the first detection cup, and by mixing module to liquid blending in the first detection cup；Pass through
Suction needle washer is carried out to suction needle outer wall；
Step 2, by suction needle from first detection cup in draw quantitation dilution, mix after blood sample be transferred to the second detection
Cup, diluent add module adds quantitative diluent in the second detection cup, and the blood sample coming with suction needle transfer carry out dilute
Release, by mixing module to liquid blending in the second detection cup, the second grain count detection means detects to second after mixing in cup
Blood sample carries out erythrocyte and platelets analysis；By suction needle washer, suction needle outer wall is carried out；
Step 3, quantitative hemolytic agent is added and through mixing module to first in the first detection cup by hemolytic agent add module
After liquid blending in detection cup, the first grain count detection means and transmission optical detection device are respectively to mixing in the first detection cup
Blood sample carry out white blood cell detection and hemoglobin detection；
Step 4, by suction needle movement to biochemical reagents position, draw quantitative biochemical reagents and be simultaneously transferred to the first detection cup, again
Mix liquid in the first detection cup, using transmission optical detection device, the dilute sample adding mixing after biochemical reagents is examined
Survey, obtain the testing result of corresponding biochemical project.
8. the detection method of hemocyte according to claim 7 and bio-chemical detector is it is characterised in that use in step 4
Scattering optical detection device is replaced transmission optical detection device and the biochemical in sample is detected, and obtains biochemical item accordingly
Mesh testing result.
9. hemocyte according to claim 7 and bio-chemical detector detection method it is characterised in that instrument detection when from
Move and biochemical item detection result be modified, testing result modified computing formulae is as follows:
Wherein modifying factor a is for revising the error that other influence factors lead in the range from 0.3-4.0.
10. the detection method of hemocyte according to claim 7 and bio-chemical detector is it is characterised in that the first granule meter
Number detection means and transmission optical detection device carry out respectively leukocyte and hemoglobin detection after, to first detection cup in add sugar
Change hemoglobin reagent and mix, scattering optical detection device carries out glycolated hemoglobin detection to liquid after mixing, according to blood red
Protein Detection result and glycolated hemoglobin testing result calculate the ratio that glycolated hemoglobin accounts for hemoglobin.
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| CN201610687366.XA CN106370584A (en) | 2016-08-17 | 2016-08-17 | Blood corpuscle detection and biochemical detection instrument and detection method thereof |
| PCT/CN2017/070574 WO2018032718A1 (en) | 2016-08-17 | 2017-01-08 | Blood cell and biochemical assay device, and assay method thereof |
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