CN106344132B - an embryo transfer tube - Google Patents

Abstract

The invention relates to an embryo transfer tube. The embryo transfer tube includes an outer tube, a heat preservation tube, and an embryo tube; The outer tube is connected to the outer tube; the outer tube includes a straight part and a curved part, and the curved part and the straight part are integrally formed at one time. One end of the straight part is provided with a fixing bolt, and the other end is provided with a cervical ostium fixing piece. The cervical os fixed part is movably connected to the straight part of the outer tube; the curved part is marked with a scale, and the outer peripheral surface of the curved part is covered with a closed cap. Its advantages are as follows: an embryo transfer tube of the present invention has low cost, is convenient for clinicians and laboratory personnel to operate, improves transplantation efficiency, shortens operation time, has a fixing function, conforms to the physiological anatomical structure of the human body, and ensures that the embryo is implanted It is in a constant temperature state before, which can improve the implantation rate and pregnancy rate of embryos, and can be further applied in clinical practice in the future.

Description

an embryo transfer tube

technical field

The invention relates to the technical field of fetal transplantation, in particular to an embryo transfer tube.

Background technique

In vitro fertilization-embryo transfer technology (commonly known as test-tube baby) is an effective means to treat refractory infertility. In general, it is divided into the following steps: ovulation induction, egg retrieval, in vitro fertilization, embryo transfer and luteal support. Among them, in vitro fertilization-embryo transfer is a process in which gametes form embryos outside the body, and then the embryos are transplanted back into the female body, which plays a connecting role in IVF. Embryo transfer is one of the key links, but the existing embryo transfer operation has the following deficiencies and defects.

First of all, the embryo transfer tube used in the prior art is usually imported from abroad, and the cost is high. The embryo transfer tube in the existing technology is a sleeve-type structure of 4 independent parts, including an inner core, an outer sleeve, an embryo tube, etc. When operating, it is necessary to operate in strict accordance with the corresponding order, such as inserting the inner core and the outer sleeve into the uterine cavity, then pulling out the inner core, and then inserting the embryo into the outer sleeve. Such repeated intubation and extubation make the operation inconvenient and the operation time is long, which increases the chance of embryos being exposed to room temperature and causes certain damage to the embryos.

In addition, in the prior art, usually the clinician first inserts the transplanted outer tube into the uterine cavity, and then notifies the laboratory doctor to load the embryo into the transplanted inner tube. Embryo transfer is divided into fresh embryo transfer and frozen embryo transfer. Embryos are stored in liquid at 37°C. Most frozen embryos are preserved by vitrification. The temperature of the resuscitation fluid for vitrification recovery is 37°C. The embryo freezing ring is placed above the solution at 37°C for rewarming. Tubes are loaded before transplantation. However, embryos will be kept at room temperature (25°C) for a period of time after tube loading and before transfer. The length of exposure to this environment may affect the implantation rate and pregnancy rate of embryos.

Secondly, there is a layer of outer casing outside the embryo transfer tube, but it has no heat preservation effect and cannot guarantee a constant ideal temperature of 37°C.

Furthermore, the embryo transfer tube in the prior art has no fixed structure at the cervix, and cannot be fixed during the embryo transfer process, and it is easy to shift during operation. In addition, the outer cannula in the prior art is a straight tube structure , Improper operation can easily cause damage. The straight tube type does not conform to the physiological and anatomical structure of the human body. The physiological and anatomical structures of different human bodies are different, and the bending angles are different. The straight tube type prevents the embryo from being implanted in a reasonable position.

To sum up, there is an urgent need for a low-cost, easy-to-operate method that ensures that the embryo is in a constant temperature state before implantation, does not affect the quality of the embryo, has a fixing effect, conforms to the physiological anatomical structure of the human body, and can increase the implantation rate of the embryo. Embryo transfer tubes for pregnancy rates. And there is no report about this embryo transfer tube at present.

Contents of the invention

The purpose of the present invention is to address the deficiencies in the prior art, to provide a low cost, simple operation, to ensure that the embryo is in a constant temperature state before implantation, does not affect the quality of the embryo, has a fixing effect, conforms to the physiological anatomical structure of the human body, An embryo transfer tube that can increase the implantation rate and pregnancy rate of embryos.

For realizing above-mentioned object, the technical scheme that the present invention takes is:

An embryo transfer tube, the embryo transfer tube includes an outer tube, a heat preservation tube, and an embryo tube; the heat preservation tube is an open-close structure, and the heat preservation tube includes a heating layer and a heat preservation layer; the heat preservation tube is connected Outer tube; one end of the embryonic tube is provided with a Luer connector, and the other end is assembled in the outer tube; the outer tube includes a straight part and a curved part, the curved part and the straight part are integrally formed at one time, and the straight part One end is provided with a fixing bolt, and the other end is provided with a cervix ostium fixture, and the cervix ostium fixture is movably connected to the straight part of the outer tube; the curved part is marked with a scale, and the outer peripheral surface of the curved part is covered with Closing cap; said heat preservation tube, outer tube and embryonic tube are coaxial.

Preferably, the outer tube is made of elastic, transparent and hard material.

Preferably, the diameter of the outer tube is 3mm.

Preferably, the embryonic tube includes a hard tube part and a soft tube part, the diameter of the hard tube part is 2 mm, the diameter of the soft tube part is 1.8 mm, and the length of the soft tube part is 9 mm.

Preferably, the cervical ostium fixing member is coaxial with the outer tube.

Preferably, the cervix fixing member is in the shape of a truncated cone.

Preferably, the length of the bent portion is 19mm.

Preferably, the closure cap has an open structure at one end and a closed structure at the other end.

Preferably, the length of the insulation pipe is 14.5cm.

Preferably, the heat insulating layer is made of polyurethane material; the heat generating layer is made of carbon fiber material.

The present invention has the advantage that:

1. An embryo transfer tube of the present invention is low in cost, easy to operate by clinicians and laboratory personnel, improves transplantation efficiency, shortens operation time, has a fixing effect, conforms to the physiological anatomical structure of the human body, and ensures that the embryo is in a position before implantation. The state of constant temperature does not affect the quality of embryos, and can increase the implantation rate and pregnancy rate of embryos. It will be further promoted and applied clinically in the future to bring good pregnancy to more patients;

2. Equipped with an insulated tube. From the time the embryo is placed in the tube to before the embryo is transferred into the uterine cavity, the environment outside the embryo is always at 37°C, which improves the adaptability and quality of the embryo, thereby increasing the implantation rate and pregnancy rate of the embryo;

3. The heat preservation tube is an open-close structure, which can be opened directly, can be easily sterilized, can be reused, and reduces the cost. There is no need to move the transfer tube back and forth during embryo transfer, which is easy to operate and has good maneuverability;

4. The insulation tube, the outer tube and the embryo tube can be connected together to form a special embryo transfer tube, which can be used for embryo tube loading and embryo transfer at the same time. The operation is simple, one step in place, and the work efficiency of the operator is improved;

5. The outer tube includes a curved part and a straight part. The curved part can be fixed at a certain angle relative to the straight part according to needs, which conforms to the physiological and anatomical structure of the human body;

6. There is a scale on the bending part of the outer tube, which can assist the operator to determine the insertion depth;

7. One end of the straight part of the outer tube is provided with a cervix fixing piece. The cervix fixing piece is designed in the shape of a truncated cone. When in use, the cervix fixing piece is used to fix the internal os of the human cervix. On the one hand, the embryo transfer tube has a support Point, good stability, which is conducive to embryo implantation; on the other hand, it can prevent the embryo transfer tube from being displaced due to improper operation.

Description of drawings

Accompanying drawing 1 is a kind of embryo transfer tube structure schematic diagram of the present invention.

Accompanying drawing 2 is the A-A sectional right view of Fig. 1.

Accompanying drawing 3 is the B-B sectional left view of Fig. 1.

Accompanying drawing 4 is the C-C sectional left view of Fig. 1.

Accompanying drawing 5 is a schematic diagram of the disassembled structure of an embryo transfer tube of the present invention.

Detailed ways

The specific embodiments provided by the present invention will be described in detail below in conjunction with the accompanying drawings.

The reference signs and components involved in the accompanying drawings are as follows:

1. Outer tube 11. Straight part

12. Bending part 2. Insulation pipe

3. Embryo tube 31. Luer connector

32. Hard pipe part 33. Hose part

4. Fixing bolt 5. Cervix fixation piece

6. Closed cap

Please refer to FIG. 1 , which is a structural schematic diagram of an embryo transfer tube of the present invention. An embryo transfer tube, the embryo transfer tube includes an outer tube 1, an insulated tube 2, and an embryo tube 3; the insulated tube 2 is connected to the outer tube 1; one end of the embryo tube 3 is provided with a Luer connector 31 , the other end is assembled in the outer tube 1; the outer tube 1 is made of elastic and transparent hard material; the outer tube 1 includes a straight part 11 and a curved part 12, and one end of the straight part 11 is provided with The fixing bolt 4 is provided with a cervix fixing member 5 at the other end; a scale is marked on the curved portion 12 , and a closing cap 6 is covered on the outer peripheral surface of the curved portion 12 .

Please refer to FIG. 2 . FIG. 2 is a right side view of A-A section in FIG. 1 . Described insulation tube 2, outer tube 1, embryonic tube 3 coaxial; The diameter of described outer tube 1 is 3mm; Described embryonic tube 3 comprises hard tube part 32 and flexible tube part 33; Described hard tube part 32 The diameter is 2mm.

Please refer to FIG. 3 . FIG. 3 is a left side view of the section B-B in FIG. 1 . The diameter of the hose part 33 of the embryo tube 3 is 1.8 mm, and the length of the hose part 33 is 9 mm.

Please refer to FIG. 4 . FIG. 4 is a left side view of the section C-C in FIG. 1 . The cervix fixing member 5 is coaxial with the outer tube 1 .

Please refer to FIG. 5 , which is a schematic diagram of a disassembled structure of an embryo transfer tube of the present invention. The curved part 12 and the straight part 11 of the outer tube 1 are integrally formed at one time; the length of the curved part 12 is 19mm; It is movably connected on the straight part 11 of the outer pipe 1; one end of the closed cap 6 is open, and the other end is a closed structure; the heat preservation pipe 2 is a structure of opening and closing, and the length of the heat preservation pipe 2 is 14.5cm. The thermal insulation pipe 2 includes a heating layer and a thermal insulation layer, the thermal insulation layer is made of polyurethane material; the heating layer is made of carbon fiber material.

It should be noted that: the insulation tube 2, the outer tube 1, and the embryo tube 3 can be connected together to form a special embryo transfer tube, which can be used for embryo tube loading and embryo transfer at the same time. Compared with the prior art, there is no need to strictly follow the order Using the corresponding instruments, there is no need for repeated intubation and extubation, the operation is simple, one step is in place, and the work efficiency of the operator is improved.

The insulation pipe 2 is provided with a heating layer and an insulation layer. The heating layer is made of carbon fiber material and can be heated by charging to increase the temperature, which is higher than the temperature environment (25° C.). 37°C, because there is an insulation layer on the outer peripheral surface of the heating layer, and the temperature layer is made of polyurethane material, which can keep the temperature at 37°C for a long time. That is, the environment outside the embryo is always at 37°C from the time the embryo is placed in the tube to before the embryo is transferred into the uterine cavity, which improves the adaptability and quality of the embryo, thereby increasing the implantation rate and pregnancy rate of the embryo.

The heat preservation tube 2 has an open-close structure, can be opened directly, can be conveniently sterilized, can be reused, and reduces the cost, and there is no need to move the transfer tube back and forth during embryo transfer, which is easy to operate and has good maneuverability.

The outer tube 1 includes a curved part 12 and a straight part 11. The curved part 12 can be fixed at a certain angle relative to the straight part 11 according to needs, which conforms to the physiological and anatomical structure of the human body. Because the passage from the human vagina to the uterus is in a curved structure, Moreover, different human bodies have different degrees of curvature. By setting the curved portion 12, it can be adapted to the physiological structure of different human bodies, thereby ensuring that the embryo can be successfully transplanted to a reasonable position; the curved portion 12 on the outer tube 1 is provided with a scale, which can assist the operator to judge The depth of insertion; the outer tube 1 is made of elastic and transparent hard material, and its transparent outer tube 1 only needs to facilitate the operator to observe the implantation of the embryo tube 3; the outer tube 1 is made of elastic hard material, as long as the outer tube 1 is increased The hardness of the tube 1 can be easily controlled.

One end of the straight part 11 of the outer tube 1 is provided with a cervical os fixing part 5, and the cervix orifice fixing part 5 is designed in the shape of a truncated cone. On the one hand, the embryo transfer tube has a supporting point and has good stability, which is beneficial to embryo implantation; on the other hand, it can prevent the embryo transfer tube from being displaced due to improper operation.

A closing cap 6 is provided, which can be sealed on the curved portion 12 of the outer tube 1 when not in use, so as to prevent external germs and dust from entering the tube body and has a protective effect.

A method of using the embryo transfer tube of the present invention is as follows: firstly, charge-type heating is carried out to the heat preservation pipe 2, so that the temperature of the heat preservation pipe 2 rises to 37°C; The angle of the curved part 12 of the tube 1; then, rotate the fixing bolt 4, disassemble the embryonic tube 3, and install the embryonic tube 3, and then put it into the outer tube 1; finally, insert the outer tube 1, and ensure that the cervical The mouth fixing part 5 is fixed in the cervix of the human body, and the embryo tube 3 with the embryo loaded is placed into the uterus along the channel of the outer tube 1, so as to realize embryo transfer.

An embryo transfer tube of the present invention has low cost, is convenient for clinicians and laboratory personnel to operate, improves transplantation efficiency, shortens operation time, has a fixing function, conforms to the physiological anatomical structure of the human body, and ensures that the embryo is in a constant temperature environment before implantation. state, does not affect the quality of the embryo, can improve the implantation rate and pregnancy rate of the embryo, and will be further promoted and applied clinically in the future to bring good pregnancy to more patients; there is an insulation tube 2, and the embryo starts from the tube to the embryo transfer into the embryo. In front of the uterine cavity, the environment outside the embryo is always at 37°C, which improves the adaptability and quality of the embryo, thereby increasing the implantation rate and pregnancy rate of the embryo; the insulation tube 2 is an open-close structure, can be opened directly, can be easily sterilized, and can be reused , which reduces the cost, and there is no need to move the transfer tube back and forth during embryo transfer, which is easy to operate and has good maneuverability; the insulation tube 2, the outer tube 1, and the embryo tube 3 can be connected together to form a special embryo transfer tube, which can be used simultaneously Embryo loading and embryo transfer are easy to operate and can be done in one step, improving the work efficiency of the operator; the outer tube 1 includes a curved part 12 and a straight part 11, and the curved part 12 can be fixed at a certain angle relative to the straight part 11 as required , in line with the physiological and anatomical structure of the human body; a scale is provided on the curved portion 12 of the outer tube 1, which can assist the operator to determine the depth of insertion; one end of the straight portion 11 of the outer tube 1 is provided with a cervical ostium fixation piece 5, and the cervical ostium The fixing part 5 is designed in the shape of a truncated cone. When in use, the cervical opening fixing part 5 is used to be fixed on the internal os of the cervix of a human body. On the one hand, the embryo transfer tube has a supporting point and has good stability, which is beneficial to embryo implantation; on the other hand, it can prevent the embryo transfer tube from being displaced due to improper operation.

The above is only a preferred embodiment of the present invention, it should be pointed out that for those of ordinary skill in the art, without departing from the method of the present invention, some improvements and supplements can also be made, and these improvements and supplements should also be considered Be the protection scope of the present invention.

Claims (10)

1. a kind of embryo transplantation tube, the embryo transplantation tube includes outer tube, insulating tube, embryo tube；Described embryo tube one end Equipped with female Luer, the other end is assemblied in outer tube；It is characterized in that, the insulating tube is the structure type of folding, heat preservation Pipe includes heating layer and insulating layer；Outer tube is connected in the insulating tube；The outer tube includes straight portion and bending section, bending section Be with straight portion it is Integratively formed, the one end in straight portion is equipped with fixing bolt, and the other end is equipped with cervix opening fixing piece, described Cervix opening fixing piece be movably connected in the straight portion of outer tube；There is label on the bending section, outside bending section Circumferential surface is cased with closing cover；The insulating tube, outer tube, embryo tube coaxial line.

2. embryo transplantation tube according to claim 1, which is characterized in that the outer tube is used with elastic, transparent hard Material is fabricated.

3. embryo transplantation tube according to claim 1 or 2, which is characterized in that the diameter of the outer tube is 3mm.

4. embryo transplantation tube according to claim 1, which is characterized in that the embryo tube includes hard pipe section and hose Portion, the diameter of hard pipe section are 2mm, and hose sections diameter is 1.8mm, and the length of hose sections is 9mm.

5. embryo transplantation tube according to claim 1, which is characterized in that the cervix opening fixing piece is coaxial with outer tube Line.

6. embryo transplantation tube according to claim 5, which is characterized in that the cervix opening fixing piece is taper type.

7. embryo transplantation tube according to claim 1, which is characterized in that the length of the bending section is 19mm.

8. embryo transplantation tube according to claim 1, which is characterized in that closing cover structure open at one end, it is another End is enclosed construction.

9. embryo transplantation tube according to claim 1, which is characterized in that the length of the insulating tube is 14.5cm.

10. embryo transplantation tube according to claim 1, which is characterized in that the insulating layer uses polyurethane material system It makes；The heating layer is fabricated using carbon fibre material.