CN106309483A - Inflammation-diminishing paste for dental pulp, and preparation method of inflammation-diminishing paste - Google Patents

Abstract

The invention provides a pulp anti-inflammatory paste, the pulp anti-inflammatory paste comprises active ingredients, the active ingredients are composed of iodoform, metronidazole, ciprofloxacin and chitosan, each component The content in the active ingredient is as follows: 10-40 parts by weight of iodoform, 10-40 parts by weight of metronidazole, 10-40 parts by weight of ciprofloxacin, and 5-20 parts by weight of chitosan. The present invention has the following technical effects: 1. The present invention has good antibacterial and anti-inflammatory effects, stable and long-lasting drug effect, strong permeability, and can promote the recovery of normal physiological functions of dental pulp, thereby significantly improving the success rate of pulp preservation in affected teeth. 2. Compared with the traditional root canal therapy, the present invention is used in clinical practice. It is easy for oral clinicians to operate, the treatment time is short, and the number of follow-up visits for patients is small, which greatly improves the treatment efficiency of pulp diseases. Because there is no need for mechanical preparation, secondary damage to the root canal wall tissue is avoided, and the risk of tooth fracture is reduced.

Description

A kind of pulp anti-inflammatory paste and preparation method thereof

technical field

The invention relates to a pharmaceutical composition, in particular to a dental pulp anti-inflammatory paste, in particular to a dental pulp anti-inflammatory paste and a preparation method thereof. The paste has strong bactericidal effect, can improve tissue repair ability, and can inhibit bacterial reproduction, and has significant curative effect on various diseases such as pulp inflammation.

Background technique

Pulp is the loose connective tissue located in the pulp cavity of the tooth, surrounded by hard dentin. Factors such as dental caries, tooth trauma, and abnormal tooth structure can lead to infection and necrosis of the dental pulp. Once the pulp is inflamed, it often Not easy to cure. At present, for teeth with pulp disease, root canal treatment is usually performed clinically to completely remove the entire pulp tissue. After root canal treatment, the nutrition metabolism of the tooth is only supplied by the periodontal tissue, and the tooth loses vitality and discoloration. At the same time, the tooth loses sensory and defense functions, and the tooth tissue becomes brittle and prone to fracture. In addition, due to the complexity of the tooth pulp cavity structure and root canal morphology, it is difficult to clean the pulp tissue in the side branch root canals clinically, which leads to the failure of root canal treatment. Therefore, it is the common goal of the industry to preserve the viable pulp tissue as much as possible and to find a more ideal and reliable treatment method. Therefore, it is necessary to develop an anti-inflammatory drug for dental pulp. On the basis of promoting inflammation subsidence, promoting the repair and regeneration of dental pulp tissue to the greatest extent is the key to improving the therapeutic effect of dental pulp diseases.

Contents of the invention

The purpose of the present invention is to aim at the nutrient metabolism of the existing pulp tissue during root canal treatment, only the periodontal tissue is supplied, and the tooth loses vitality and discoloration, and at the same time the tooth loses sensory and defense functions, and the tooth tissue becomes brittle and easily In order to solve the problem of fracture, we invented a kind of dental pulp that can effectively treat a variety of periapical lesions including irreversible pulpitis, preserve the vitality of pulp tissue, promote the regression of inflammation, the regeneration of pulp tissue and The pulp anti-inflammatory paste for restoring its function also provides a corresponding preparation method.

Pulp anti-inflammatory paste of the present invention comprises active ingredient, and described active ingredient is made up of iodoform, metronidazole, ciprofloxacin and chitosan, and the content of each component in active ingredient is as follows: iodoform 10 ~40 parts by weight, 10~40 parts by weight of metronidazole, 10~40 parts by weight of ciprofloxacin, and 5~20 parts by weight of chitosan.

Described pulp anti-inflammatory paste also includes oral cavity paste base, and described oral cavity paste base is olive oil or polysiloxane oil; The weight-to-volume ratio of described active ingredient and oral cavity paste base is 1 gram: 1~1.5mL.

Described pulp anti-inflammatory paste also includes oral paste base, and every 33g active ingredient is added with the oral paste base that comprises following composition:

Component A: 1 mL of citric acid with a mass concentration of 19%, 0.015 g of ethylparaben, and 100 mL of distilled water;

Component B: Glycerin 10 mL.

The preparation method of dental pulp anti-inflammatory paste of the present invention may further comprise the steps:

1) Grinding metronidazole, ciprofloxacin, iodoform and chitosan into a fine powder according to the set weight ratio, passing through a 100-mesh sieve to obtain a powder;

2) Mix the powder prepared above with the oral paste base until creamy, to obtain a uniformly stirred paste preparation.

The preparation method of dental pulp anti-inflammatory paste of the present invention may further comprise the steps:

1) Grinding metronidazole, ciprofloxacin and iodoform according to the set weight ratio into fine powder, passing through a 100-mesh sieve to obtain powder;

2) Dissolve citric acid in distilled water and mix evenly, add ethylparaben and mix evenly, add chitosan during stirring to form a gel matrix;

3) Stir the ground metronidazole, ciprofloxacin and iodoform powder with glycerin evenly, slowly add it into the gel matrix under stirring, and stir well to get the pulp anti-inflammatory paste.

The usage method of the dental pulp anti-inflammatory paste of the present invention: directly inject the paste into the root canal.

Mechanism of action of the present invention is as follows:

The paste of the present invention mainly uses antibiotics such as iodoform, metronidazole and ciprofloxacin as main raw materials, and is uniformly mixed with chitosan and related paste bases in a certain proportion during production. Among them, metronidazole is a typical anti-anaerobic drug, which has excellent bactericidal effect on obligate anaerobic bacteria existing in dentinal tubules. Ciprofloxacin has a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli, and often has antibacterial activity against multi-drug resistant bacteria. repair. In addition, iodoform has high-efficiency anti-corrosion properties, strong affinity with tissues, strong antibacterial ability, non-irritating to tissues, and can produce long-lasting sterilization, disinfection and deodorization effects. Moreover, iodoform can dissolve in interstitial fluid, and it can release iodine slowly when encountering interstitial fluid, fat and bacterial products. Free iodine can oxidize the active gene of bacterial protoplasmic protein, combine with the amino group of the protein to denature it, and has a good disinfection and sterilization effect. While sterilizing, it can also absorb the exudate in the root canal and promote the healing of the lesion. Chitosan has broad-spectrum antibacterial properties, good biocompatibility, low immune antigenicity, can be absorbed and utilized by the human body, and provides a buffer space for inflammation exudation and drug release. Tissue has the function of promoting healing, and can promote the formation of restorative dentin, and has the effect of protecting teeth and strengthening teeth.

Compared with traditional root canal treatment, this product is easy to operate, short treatment time, fewer follow-up visits, high cure rate, good prognosis, and has broad clinical application prospects. Antibacterial tests, clinical pharmacology, safety toxicology, and cytotoxicity experiments have been carried out on this product, and it is fully qualified and can be used for a long time.

The present invention has following technical effect:

1. The present invention has good antibacterial and anti-inflammatory effects, stable and long-lasting drug effect, strong permeability, and can promote the recovery of normal physiological functions of dental pulp, thereby significantly improving the success rate of vital pulp preservation of affected teeth.

2. Compared with the traditional root canal therapy, the present invention can be used in clinical practice, which is easy for oral clinicians to operate, shortens the treatment time, and reduces the number of follow-up visits of patients, which greatly improves the treatment efficiency of endodontic diseases. Because there is no need for mechanical preparation, secondary damage to the root canal wall tissue is avoided, and the risk of tooth fracture is reduced.

3. The present invention uses chitosan creatively. Chitosan is another indispensable vital element of the human body after protein, fat, carbohydrates, vitamins and minerals. It is widely used in food and medicine and can be absorbed by the human body. Utilization can provide a buffer space for the exudation of inflammation and the release of drugs. At the same time, it can guide tissue regeneration, promote healing of bone tissue, and promote the formation of restorative dentin, which has the effect of protecting teeth.

4. The medicine used in the paste formula of the present invention is low in cost, easy to use, safe and effective, convenient for large-scale clinical promotion and application, and can greatly save effective medical resources in my country.

5. The present invention has a reasonable prescription, is safe and reliable, has sufficient drug sources, is convenient to operate, has strong antibacterial properties, can effectively preserve the vitality of the affected tooth pulp, and promotes tissue repair and regeneration. Inflammation such as periapical inflammation provides new options and is a new direction for the development of stomatology in the future.

Description of drawings

Figure 1 is the preoperative X-ray film: the pulp infection, the root is not fully developed, and the apex is not closed.

Figure 2 is an intraoperative X-ray film: Pulp anti-inflammatory paste was placed for anti-inflammation.

Figure 3 is the postoperative X-ray film: the root has completed development and the apex is closed.

detailed description

The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

Example 1

The pulp anti-inflammatory paste of this embodiment includes a paste base and an active ingredient, and the active ingredients are as follows: 10 g of iodoform, 10 g of metronidazole, 10 g of ciprofloxacin, 5 g of chitosan, and 35 mL of the paste base olive oil.

The pulp anti-inflammatory paste of the present embodiment is prepared by the following method:

1) Grinding iodoform, metronidazole, ciprofloxacin and chitosan into fine powder, passing through a 100-mesh sieve to obtain powder;

2) Add the paste base to the powder prepared above, mix and stir until creamy, and obtain a uniformly stirred paste preparation;

3) Sterilize and repack the obtained paste preparation;

4) Store the subpackaged sterilizing paste in a dry, cool and dark place for later use.

Example 2

The pulp anti-inflammatory paste of the present embodiment includes a paste base and active ingredients, and the active ingredients are as follows: 25 g of iodoform, 25 g of metronidazole, 25 g of ciprofloxacin, 15 g of chitosan, and 135 mL of the paste base olive oil.

The preparation method is the same as in Example 1.

Example 3

The pulp anti-inflammatory paste of this embodiment includes a paste matrix and active ingredients, and the active ingredients are as follows: 40 g of iodoform, 40 g of metronidazole, 40 g of ciprofloxacin, 20 g of chitosan, and 170 mL of the paste base Methicone.

The preparation method is the same as in Example 1.

Example 4

The pulp anti-inflammatory paste of the present embodiment comprises a paste base and an active ingredient;

The active ingredients are as follows: iodoform 10 g, metronidazole 10 g, ciprofloxacin 10 g, chitosan 3 g.

The paste base composition is as follows:

Component A, 1 mL of citric acid with a mass concentration of 19%, 0.015 g of ethylparaben, and 100 mL of distilled water;

Component B, Glycerin 10 mL.

The pulp anti-inflammatory paste of the present embodiment is prepared by the following method:

1) Grinding iodoform, metronidazole and ciprofloxacin into fine powder, passing through a 100-mesh sieve to obtain powder;

2) Dissolve 1 mL of citric acid with a mass concentration of 19% in 100 mL of distilled water and mix evenly, then add 0.015 g of ethylparaben and mix evenly, and add 3 g of pharmaceutical grade chitosan to the stirring to form a gel matrix;

3) Stir the ground metronidazole, ciprofloxacin and iodoform powder with 10mL of glycerin evenly, slowly add it into the gel matrix under stirring, and stir well to get the pulp anti-inflammatory paste;

4) Sterilize and repack the obtained paste preparation;

5) Store the subpackaged sterilizing paste in a dry, cool and dark place for later use.

Example 5

A case of periapical periodontitis of a young permanent tooth was treated with the dental pulp anti-inflammatory paste of Example 1 of the present invention. Figures 1-3 are comparison charts of the effects during the treatment.

As shown in Figure 1, it is the preoperative X-ray film of the patient: the pulp is infected, the root is not fully developed, and the apex is not closed.

Adopt paste of the present invention to treat, concrete operation steps are as follows:

1. Routine local anesthesia, rubber dam, and disinfection of the affected tooth;

2. Routinely remove the decayed tooth and prepare the hole, open the pulp and uncover the roof, and remove the necrotic crown pulp;

3. After thoroughly flushing the pulp cavity with a large amount of medicine, put the pulp anti-inflammatory paste at the root canal opening, and fill it with glass ionomer. Pulp anti-inflammatory paste was placed during the treatment for anti-inflammation, the X-ray film is shown in Figure 2;

5. Regular follow-up visits, the symptoms improved, part of the glass ion was removed, and the resin was filled permanently;

6. X-ray film and clinical evaluation were carried out after 2 years of follow-up. The electrical vitality of the pulp was restored to the same as that of the control tooth. As shown in the X-ray film of Figure 3, the root development is almost complete, and the tooth has no discoloration.

The therapeutic effect of embodiment 2-4 is all similar with embodiment 1.

After three years and 200 cases of clinical use, the effect is similar to that in Figure 3.

This proves that the anti-inflammatory paste of the present invention has an ideal therapeutic effect without any side effects, and is worthy of clinical promotion.

The above is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the description of the present invention and the contents of the accompanying drawings, or directly or indirectly used in other related technologies fields, all of which are equally included in the scope of patent protection of the present invention.

The parts not involved in the present invention are the same as the prior art or can be realized by adopting the prior art.

Claims (5)

1. a dental pulp inflammation relieving paste, it is characterised in that described dental pulp inflammation relieving paste includes active component, described activity one-tenth Dividing and be made up of iodoform, metronidazole, ciprofloxacin and chitosan, each component content in active component is as follows: iodoform 10 ~ 40 Weight portion, metronidazole 10 ~ 40 weight portion, ciprofloxacin 10 ~ 40 weight portion, chitosan 5 ~ 20 weight portion.

Dental pulp inflammation relieving paste the most according to claim 1, it is characterised in that described dental pulp inflammation relieving paste also includes oral cavity Using paste substrate, described oral cavity paste substrate is olive oil or polysiloxane oil；Described active component and oral cavity are stuck with paste The w/v of agent substrate is 1 gram: 1 ~ 1.5mL.

Dental pulp inflammation relieving paste the most according to claim 1, it is characterised in that described dental pulp inflammation relieving paste also includes oral cavity Using paste substrate, every 33g active component is added with the oral cavity paste substrate including following composition:

Composition A: mass concentration is the citric acid 1mL of 19%, ethyl hydroxybenzoate 0.015 gram, distilled water 100mL；

Composition B: glycerol 10mL.

4. the preparation method of dental pulp inflammation relieving paste as claimed in claim 2, it is characterised in that comprise the steps:

1) by metronidazole, ciprofloxacin, iodoform and chitosan by the weight proportion set, grind to form fine powder, cross 100 mesh sieves, To powder；

2) with oral cavity paste substrate, the above-mentioned powder preparing gained is mixed tune to mix to butyrous, obtain the paste stirred Preparation.

5. the preparation method of dental pulp inflammation relieving paste as claimed in claim 3, it is characterised in that comprise the steps:

1) by metronidazole, ciprofloxacin and iodoform by the weight proportion set, grind to form fine powder, cross 100 mesh sieves, obtain powder；

2) citric acid is dissolved in mix homogeneously in distilled water, then adds ethyl hydroxybenzoate mixing, in stirring, add chitosan make into Gel-type vehicle；

3) first ground metronidazole, ciprofloxacin and iodoform powder are stirred with glycerol, the most slowly add to coagulate In gel matrix, stir evenly and i.e. obtain dental pulp inflammation relieving paste.