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CN106259953A - Breast milk 0-12 month babies ' formula milk powder containing nucleotide and preparation method thereof - Google Patents

Breast milk 0-12 month babies ' formula milk powder containing nucleotide and preparation method thereof Download PDF

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CN106259953A
CN106259953A CN201510300587.2A CN201510300587A CN106259953A CN 106259953 A CN106259953 A CN 106259953A CN 201510300587 A CN201510300587 A CN 201510300587A CN 106259953 A CN106259953 A CN 106259953A
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powder
milk
nucleotide
vitamin
content
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CN106259953B (en
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赵红霞
刘彪
李威
陈青山
方芳
李婷
赵子夫
齐炳理
司徒文佑
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Inner Mongolia Yili Industrial Group Co Ltd
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Inner Mongolia Yili Industrial Group Co Ltd
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Abstract

The invention provides a kind of breast milk 0-12 month babies ' formula milk powder containing nucleotide and preparation method thereof, total protein content in described milk powder is 10.5～18g/100g, it is 48～61% that lactalbumin accounts for the ratio of total protein, alpha lactalbumin content is 1.25～1.8g/100g, beta-casein content is 2.2～3.7g/100g, lactoferrin content 35～60mg/100g, fat content is 20～29g/100g, linoleic acid content is 2600～4500mg/100g, alpha-linolenic acid content is 350～450mg/100g, carbohydrate content is 52～56g/100g, total nucleotide content is calculated as 26～58mg/100g with nucleic acid molecule total amount.This milk powder, closer to breast milk, can promote baby and exempt from power.

Description

Breast milk 0-12 month babies ' formula milk powder containing nucleotide and preparation method thereof
Technical field
The present invention relates to a kind of infant formula, in particular to a kind of breast milk 0-12 containing nucleotide Month babies ' formula milk powder and preparation method thereof.
Background technology
At present, breast milk remains the Development Trend of baby (infant refers to the people at 0～12 monthly ages) formula milk.Baby Youngster's formula milk breast milkization design marrow be so that formula milk on feeding effect close with breast milk.But, mesh Before commercial infant milk powder both domestic and external be the most only on physical and chemical index, to meet national standard, i.e. be in maroscopic quantity likely Close to breast milk, but in microstructure, such as Secondary structure, lipid structure and fatty acid, immune factor Etc. aspect, also there is bigger difference with breast milk.
For protein structure, domestic baby series milk powder in the market is all according to " GB 10765-2010 Infant formula " and the requirement of " GB 10767-2010 bigger infants and young formula food " by total protein Quality Control Lactalbumin and casein ratio, in the range of 12～18%, are adjusted to 60:40, although in the certain journey of maroscopic quantity by system Breast milk proteins matter composition is simulated, it is well known, however, that protein is divided into lactalbumin, casein in milk on degree With lactoferrin etc., wherein casein is divided into: αS1-casein, αS2-casein, beta-casein, κ-cheese egg In vain, lactalbumin is divided into: alpha lactalbumin (alpha-lactalbumin), beta lactoglobulin, serum albumin etc., at present Most baby series milk powder protein these more segment composition structure on differ farther out with breast milk, only really Albumen composition structure on could say that product is real protein composition structure breast milk close to breast milk.Additionally, due to Babies ' formula milk powder, a particularly 0-6 month babies ' formula milk powder, its protein composition structure there are differences with breast milk, Protein utilization is low compared with breast milk, improves the ratio of protein can be only achieved the egg of baby so generally requiring in formula White matter requirement, but, cause the burden of baby's digestive system owing to improve protein content, be easily caused baby Youngster's constipation and other pipe intestinal digesting problems.
It addition, there are many experiments to have been proven that nucleotide important function in organism.Nucleotide, is that breast milk is non- The one of proteinic nitrogen, of crucial importance to the growth promoter of natus, it can promote growth, improves immunologic function, Improve metabolism etc..2008, China allowed nucleotide to add in baby milk, but was not specified by five kinds of nucleotide The addition of component.US 4,994,442 points out be added in infant formula by various nucleotide to strengthen T Cellullar immunologic response, the most various nucleotide component (CMP, AMP, UMP, GMP and IMP) are to add with equivalent To formula food.Disclosing a kind of baby milk compositions in EP 1549158, it comprises 3.2-15.4mg/L's IMP and 2.5-13.2mg/L of GMP, 0.1-2.2mg/L of UMP, 1.8-8.0mg/L of CMP, 1.8-11.0mg/L AMP, it is intended to use to premature infant, but does not disclose any effect in the cards.Additionally, CN1212068C、CN102283289B、CN102038041B、CN101233874B、CN101218940B、 CN104222313A, CN104222314A, CN101731351A etc. all disclose various nucleotide according to specific Proportioning add in baby milk powder.The proportioning phase not to the utmost of the various nucleotide of the interpolation of these prior aries report With.
Summary of the invention
It is an object of the present invention to provide a kind of breast milk 0-12 month babies ' formula milk powder containing nucleotide, should The component of babies ' formula milk powder particularly lactoprotein, fat, nucleotide composition and ratio etc., closer to breast milk, feed effect Fruit, also closer to breast milk, is more suitable for Asia baby particularly Chinese (Chinese) baby, can promote exempting from of baby Epidemic disease power.
Another object of the present invention is to provide a kind of and prepare the described breast milk 0-12 month infant formula containing nucleotide The method of milk powder.
On the one hand, the invention provides a kind of breast milk 0-12 month babies ' formula milk powder containing nucleotide, this milk powder In total protein content be 10.5～18g/100g, it is 48～61% that lactalbumin accounts for the ratio of total protein, alpha lactalbumin Content is 1.25～1.8g/100g, and beta-casein content is 2.2～3.7g/100g, lactoferrin content 35～60mg/100g, Fat content is 20～29g/100g, and linoleic acid content is 2600～4500mg/100g, and alpha-linolenic acid content is 350～450mg/100g, carbohydrate content is 52～56g/100g, and total nucleotide content is with nucleic acid molecule total amount It is calculated as 26～58mg/100g；Wherein:
The raw material providing lactoprotein includes one or more in basic material milk, whole milk powder, defatted milk powder, also Including: one or more in the raw material lactalbumin powder that adds for fortified milk albumin, desalted whey powder, for by force The raw material alpha lactalbumin powder changing alpha lactalbumin and add, the raw material beta-casein added for strengthening beta-casein Powder, and the raw milk ferritin added for fortified milk ferritin；
There is provided the raw material of fat in addition to the basic material containing butterfat, also include vegetable oil；
The raw material providing nucleotide includes that the raw material added for strengthening nucleotide compounds nucleotide.
Inventor is by gathering whole nation key area mother's colostrum and female ripe breast, collecting and add the domestic and international product of nucleotide Board infant formula, collection cattle colostrums and ripe milk sample originally, and carry out numerous studies analysis, enter formula milk emphatically Go the adjustment of microstructure, respectively the aspects such as albumen, fat, nucleotide have been carried out breast milk design, and selects spy Fixed raw material is compounding prepares babies ' formula milk powder so that formula milk more connects with breast milk on segmentation composition and feeding effect Closely.The babies ' formula milk powder of the present invention is with Aisan, particularly Chinese han population breast milk proteins, fat, nucleotide Composition and ratio be according to and develop, be therefore more suitable for Chinese (Chinese) baby.
According to specific embodiments of the present invention, the breast milk infants containing nucleotide and OPO structured lipid of the present invention In formula milk, albumen, fat index can be done according to the infant development stage and further segment.Specifically, for 0-6 month baby: the total protein content in this milk powder is 10.5～15g/100g, and lactalbumin accounts for the ratio of total protein Being 60～61%, alpha lactalbumin content is 1.25～1.8g/100g, and beta-casein content is 2.2～3.7g/100g, breast ferrum Protein content 35～60mg/100g, fat content is 23～29g/100g, and linoleic acid content is 2600～4500mg/100g, Alpha-linolenic acid content is 350～450mg/100g, and carbohydrate content is 52～56g/100g, total nucleotide content with Nucleic acid molecule total amount is calculated as 26～58mg/100g.For 6-12 month baby: in this milk powder, total protein content is 14～18g/100g, it is 48～61% that lactalbumin accounts for the ratio of total protein, and alpha lactalbumin content is 1.25～1.8g/100g, beta-casein content is 2.2～3.7g/100g, lactoferrin content 35～60mg/100g, fat Content is 20～29g/100g, and linoleic acid content is 2600～4500mg/100g, and alpha-linolenic acid content is 350～450mg/100g, carbohydrate content is 52～56g/100g, and total nucleotide content is with nucleic acid molecule total amount It is calculated as 26～58mg/100g.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, total protein content is 10.5～18g/100g, on the basis of casein and whey protein proportions are 60:40, enhance alpha lactalbumin and Beta-casein, makes alpha lactalbumin content in product reach 1.25～1.8g/100g, and beta-casein content reaches 2.2～3.7g/100g, It is converted into alpha-whey in milk according to the ratio that reconstitutes (13～15g milk powder add water and reconstitute to 100 milliliters of milk) of product The content of albumen and beta-casein has reached breast milk level.Therefore, the present invention is by the structural adjustment to product protein Baby milk is made to have reached albumen breast milk truly.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, it is provided that the raw material of lactoprotein includes One or more in basic material milk, whole milk powder, defatted milk powder；It is preferably based on 1000 weight portions The described breast milk 0-12 month babies ' formula milk powder containing nucleotide, its raw material includes: whole milk powder 125～200 weight Amount part；Defatted milk powder 0～250 weight portion；Described whole milk powder, defatted milk powder can partly or entirely with considerable amount of entirely Fat milk, skim milk substitute.Further, for meet in the babies ' formula milk powder product of the present invention to lactalbumin, The content's index requirement of alpha lactalbumin and beta-casein, the raw material of the babies ' formula milk powder of the present invention also includes: for by force Lactalbumin powder (such as the lactalbumin powder WPC 80%, lactalbumin powder WPC 34% changing lactalbumin and add Deng), one or more in desalted whey powder (such as desalted whey powder D70, D90 etc.), preferably include milk surum Egg albumen powder WPC 80% and desalted whey powder, selectivity adds lactalbumin powder WPC 34%；And be in enhanced products Alpha lactalbumin be further added with raw material alpha lactalbumin powder, and be the beta-casein in enhanced products more It is further added with raw material beta-casein powder；It is preferably based on the described breast milk containing nucleotide of 1000 weight portions Changing 0-12 month babies ' formula milk powder, its raw material includes: lactalbumin powder 30～210 weight portion (preferably includes milk surum egg White lead WPC 80%30～90 weight portion)；Desalted whey powder 10～50 weight portion；Alpha lactalbumin powder 4～35 weight Amount part；Beta-casein powder 0.5～10 weight portion.Additionally, the breast milk 0-12 month baby containing nucleotide of the present invention Formula milk may also include the raw material of suitable fortified milk ferritin, based on containing nucleoside described in 1000 weight portions The breast milk 0-12 month babies ' formula milk powder of acid, it may include raw milk ferritin 0.35～0.60 weight portion.
In a specific embodiments of the present invention, the breast milk 0-12 month infant formula containing nucleotide of the present invention Milk powder, it is preferable that based on described in 1000 weight portions containing the breast milk infants formula milk of nucleotide, its raw material Including: whole milk powder 125～200 weight portion；Defatted milk powder 0～250 weight portion；Lactalbumin powder WPC 80% 30～90 weight portions；Desalted whey powder D9010～50 weight portions；Alpha lactalbumin powder 4～35 weight portion；β- Casoid flour 0.5～10 weight portion；Lactoferrin 0.35～0.60 weight portion.Whole milk powder therein, defatted milk powder can Partly or entirely substitute with considerable amount of whole milk, skim milk.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, compounding nucleotide is used to provide Product nucleotide.It practice, also contain certain nucleotide in Lac Bovis seu Bubali, but the nucleoside additionally added relative to the present invention For the amount of acid, the content of Lac Bovis seu Bubali nucleotide is considerably less, and major part meeting during common Lac Bovis seu Bubali is processed into milk powder Being depleted, therefore whole milk powder, defatted milk powder etc. used by the present invention almost may be used containing the basal nuclei thuja acid in milk composition raw material To ignore.Adding field at food, the nucleotide used mainly has CMP (cytidylic acid), UMP (urine Pyrimidine nucleotide), AMP (adenylic acid), GMP (guanylic acid), IMP (inosine monophosphate, IMP) Deng.The 5'-mixed nucleotides sold in the market contains 5'-AMP (AMP), 5'-CMP (CMP), 5'-bird Thuja acid (GMP), uridine 5'-monophosphate (UMP) and 5'-inosinic acid (IMP).Generally, being applied in combination when, this 5'- Mixed nucleotides can such as exist with two types: a kind of is 5'-AMP and 5'-CMP is the shape with free acid Formula exists, and other 3 kinds of nucleotide exist with sodium-salt form, is called for short two sour three sodium form；Another kind of then all with sodium salt Form exists, and is called for short five sodium form.Therefore, term used herein " nucleotide " is also contemplated by the form of its salt, such as alkali Slaine or alkali salt, such as sodium salt, potassium salt or calcium salt etc., such as one sodium salt or disodium salt etc., such as CMPNa2、 AMPNa2、UMPNa2、GMPNa2、IMPNa2And CMPK2、AMPK2、UMPK2、GMPK、IMPK2 Deng.Each nucleotide component in the compounding nucleotide of the present invention can be the most optionally and independently of one another with various salt Form exists, and includes but not limited to " two sour three sodium form " mentioned above；Or each component and salt thereof can be with arbitrarily Presented in combination, the most only GMP exists in the form of salts, only CMP existence in the form of salts etc..Alternatively, Each nucleotide component in the compounding nucleotide of the present invention can exist the most in a salt form, includes but not limited to above " five sodium form " mentioned.Equally, term used herein " nucleotide " is also contemplated by its various forms of solvates (such as water Compound).Therefore, when the compositions of the present invention comprises other forms the most listed above of nucleotide component, this A little form proportionings in the composition calculate after should being converted into the nucleic acid molecule of its correspondence.Such as, when CMP with Its disodium salt form (CMPNa2In the presence of), it should be converted into CMP to calculate corresponding weight ratio.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, the amount of described compounding nucleotide is Referring to material quantity, its nucleotide effective content is with nucleic acid molecule total amount (i.e. CMP, AMP, UMP, GMP With IMP molecule total amount) meter, if the hydrate containing each nucleotide or salt in i.e. compounding nucleotide, should convert Calculate after becoming the nucleic acid molecule of its correspondence, be 599～750mg/g.
A preferred embodiment according to the present invention, the breast milk 0-12 month baby containing nucleotide of the present invention In formula milk, in described compounding nucleotide, each nucleotide effective content with CMP, AMP, UMP, GMP, IMP molecule meter is respectively as follows:
Cytidylic acid (CMP): 365～430mg
Uridylic acid (UMP): 94～120mg
Guanyl (GMP): 70～90mg
Adenylic acid (AMP): 70～90mg
Inosinic acid (IMP): 0, or more than 0 and not higher than 20mg.
A preferred embodiment according to the present invention, the breast milk 0-12 month baby containing nucleotide of the present invention In formula milk, in described compounding nucleotide, it is converted to CMP, AMP, UMP, GMP, IMP with each nucleotide The total amount of molecule meter is 100%, and the effective percentage composition of each nucleotide is with CMP, AMP, UMP, GMP, IMP Molecule meter is respectively as follows: CMP 58～70%, AMP 7.5～12.5%, UMP 12～16.5%, GMP 10～13%, IMP It is 0 or more than 0 and not higher than 2.5%；It is preferably: CMP 59～65%, AMP 8～12.5%, UMP 14～16.5%, GMP 11～12.5%, IMP are 0 or more than 0 and not higher than 2%；More preferably CMP 59～60%, AMP 12～12.5%, UMP 16～16.5%, GMP 12～12.5%, IMP 0.Most preferably, the compounding core of the present invention Thuja acid adds in described 0-12 month infant formula, makes formula powder nucleotide ratio for (with core each in milk powder It is 100% meter that thuja acid is converted to the total amount of CMP, AMP, UMP, GMP, IMP molecule meter): CMP:60%, AMP:12%, UMP:16% and GMP:12%.
The compounding nucleotide of the present invention adds in described 0-12 month infant formula, can make formula powder nucleotide Closer to Chinese (Chinese) breast milk on composition and ratio, contribute to the raising of infant immunity.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, it is provided that product fat becomes with fat The raw material divided, in addition to the basic material (whole milk powder as the aforementioned, defatted milk powder, milk) containing butterfat, also includes Vegetable oil.Described vegetable oil can include Oleum Helianthi, Semen Maydis oil, soybean oil, low erucic acid rapeseed oil, Oleum Cocois, palm fibre One or more in palmitic acid oil, walnut oil, preferably include Oleum Helianthi, Semen Maydis oil and soybean oil.These vegetable oil Add and on the one hand provide fat constituent for product, on the other hand linoleic acid and alpha-linolenic acid are provided.It is highly preferred that this In bright, the content of the linoleic acid in raw materials used Oleum Helianthi, Semen Maydis oil, soybean oil and alpha-linolenic acid is respectively 7.6～8.9%, 0.25～0.38%, 53.0～56.20%, 0.9～1.6%, 50.0～53.5%, 7.6～9.6%.Low mustard used Acid Oleum Brassicae campestris linoleic acid and the content of alpha-linolenic acid are respectively 16～19%, 8.0～10.6%, and Oleum Cocois linoleic acid and α- Linolenic content is respectively 1～3%, 0～1%.
According to specific embodiments of the present invention, the breast milk 0-12 containing nucleotide and OPO structured lipid of the present invention Month babies ' formula milk powder, a carbohydrate part from the basic material containing lactose such as milk, whole milk powder and/ Or defatted milk powder etc., should additionally add lactose raw material in addition to provide carbohydrate.That is, the infant formula of the present invention In milk powder, it is provided that the raw material of carbohydrate, in addition to the basic material containing lactose, also includes raw material lactose.Preferably, Based on containing nucleotide and the breast milk infants formula milk of OPO structured lipid, its raw material bag described in 1000 weight portions Include: lactose 300～450 weight portion.The concrete addition of lactose can be adjusted so that the present invention's contains in the range of described The breast milk 0-12 month babies ' formula milk powder carbohydrate content of nucleotide and OPO structured lipid is 52～56g/100g.
According to specific embodiments of the present invention, the breast milk infants formula milk containing nucleotide of the present invention, it is former Material also includes suitable oligofructose, oligomeric galactose, DHA, ARA, bacillus bifidus, also includes comprising calcium The premix of powder, vitamin and mineral, is additionally included in milk powder preparation technique during spray drying used Carrier anhydrous butter oil and phospholipid.It is preferably based on 1000 weight portions described containing nucleotide and OPO structured lipid Breast milk infants formula milk, its raw material includes: oligofructose powder 5～18 weight portion；Oligomeric galactose slurry 12～42 Weight portion；Comprise premix 9～15 weight portion of calcium powder, vitamin and mineral；DHA4～9 weight portions； ARA5～9 weight portions；Bacillus bifidus 0.1～0.2 weight portion；Phosphatidase 1～2.5 weight portions；Anhydrous butter oil 0.5～1.5 weight Amount part.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, use raw material oligomeric galactose and Oligofructose provides product dietary fiber.Mostly babies ' formula milk powder in the market is single and employs oligomeric half Lactose or oligofructose.And inventor finds that oligomeric galactose has reasonable functional after studying by analysis And processing characteristics, but not as oligofructose in mouthfeel, oligofructose can slowly be decomposed under hot environment acid, Affect content and effective absorbtivity in final products, but with low cost.Inventor analyzes through each groping easily, Consider its in intestinal on the facilitation of probiotic bacteria and processing characteristics impact etc., the most finally the present invention has selected low Poly-galactose (FOS) and oligofructose (GOS) are according to the combination of special ratios.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, raw materials used bacillus bifidus is to use Product probiotic bacteria is provided.According to specific embodiments of the present invention, the breast milk baby containing nucleotide of the present invention In youngster's formula milk, the addition of bacillus bifidus is 2 × 108Cfu/g is (for meeting this requirement, generally, based on 1000 The described breast milk infants formula milk containing nucleotide of weight portion, its raw material includes bacillus bifidus 0.1～0.2 weight Part).Through verification experimental verification, the bacillus bifidus of this addition, after the milk flour producing process of the present invention, product In shelf life, viable count ensure that 2 × 106More than cfu/g.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, possibly together with specified quantitative calcium powder, Vitamin and mineral.Vitamin in breast milk and mineral are to ensure that the important guarantee of infantile health, reasonably tie up life Element addition can be supplied to the more immunity of baby, if mineral contains in the case of meeting infant nutrition needs Measuring too low meeting causes baby's skeleton and body development to delay, but if mineral is taken in too high meeting and caused baby's kidney to bear Increasing the weight of of load.Simultaneously by the adjustment of Calcium in Powdered Milk phosphorus ratio makes the calcium in product be more prone to absorb.Of the present invention The combination that premix is the nutritional labeling meeting national standard, according to different formulations use Different adding amount.This If invention formula milk adds as required nutrient alternative employing following premix composition in arbitrary Or combination in any.Preferably, described premix at least includes compounding vitamin, calcium powder, mineral, magnesium chloride With nutrient pack such as potassium chloride, each amounts of components is:
1) compounding vitamin, in every gram of compounding vitamin:
Vitamin A: 2000～3000 μ gRE
Vitamin D: 30～45 μ g
Vitamin B1: 2600～3600 μ g
Vitamin B2: 600～1000 μ g
Vitamin B6: 1650～2350 μ g
Vitamin B12: 9.1～12.0 μ g
Vitamin K: 325～430 μ g
Vitamin C: 500～720mg
Vitamin E: 28～39.1mg α-TE
Nicotiamide: 17900～24550 μ g
Folic acid: 428～553 μ g
Biotin: 66.9～98.1 μ g
Pantothenic acid: 11510～15230 μ g
Phylloxanthin: 240～1000 μ g
2) calcium powder, in every gram of calcium powder:
Calcium: 160～250mg
Phosphorus: 75～100mg
3) mineral, in every gram of mineral:
Ferrum: 40～85mg
Zinc: 33～49mg
Copper: 3800～4940 μ g
Selenium: 102～185 μ g
Iodine: 748～992 μ g
Manganese: 0～579 μ g
4) magnesium chloride, in every 1000 kilograms of milk powder:
Magnesium: 80～170g
5) potassium chloride, in every 1000 kilograms of milk powder:
Potassium: 950～1050g.
Additionally, also alternative includes that choline chloride is (containing choline in every 1000 kilograms of milk powder in described premix 300～750g), in described compounding vitamin, also alternative includes taurine (150～220mg/g).Compounding nutrition The base material of element is preferably lactose.The described breast milk infants containing nucleotide being preferably based on 1000 weight portions is joined Side's milk powder, the addition of premix is 9～15 weight portions, and wherein, compounding vitamin bag is preferably 2～3 Weight portion, calcium powder nutrient pack is preferably 2～8 weight portions, and mineral matter nutritional bag is preferably 0.5～6 weight portions, each nutrition The base material of bag is preferably lactose.Each constituent content of above-mentioned premix, refers to as strengthening described nutrient species Addition, does not include the ideal nutrient composition content in other raw materials of milk powder, such as, magnesium chloride, every 1000 kilograms of milk In powder, " magnesium: 80～170g " refers to as the magnesium elements in enhanced products, milk powder based on 1000 kilograms of weight, interpolation Magnesium chloride is calculated as 80～170g with wherein magnesium elements weight.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, raw materials used phospholipid and anhydrous milk Oil is mainly used for the molding of powder particles in spray-drying process, and described phospholipid can be soybean phospholipid and/or lecithin. The consumption of phospholipid and anhydrous butter oil is less, but also has certain contribution for fat content in milk powder product.
A preferred embodiment according to the present invention, the breast milk infants formulas containing nucleotide of the present invention Powder, its raw material includes:
Compounding nucleotide 0.45～0.65 weight portion, and its nucleotide effective dose with CMP, AMP, UMP, GMP, With IMP molecule total amount meter less than 0.58 weight portion, wherein IMP is 0～2%；
It is appreciated that in the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, the tool of each raw material Body consumption should be adjusted on the premise of meeting the requirement of formula milk product index and determine.The present invention containing core In the breast milk 0-12 month babies ' formula milk powder of thuja acid, the unspecified or product performance index listed all should be according to " GB 10765-2010 infant formula " and " GB 10767-2010 bigger infants and young formula food " and The regulation of relevant criterion and regulation performs.
In the breast milk 0-12 month babies ' formula milk powder containing nucleotide of the present invention, each raw material is the most commercially available, The selection of each raw material should meet relevant criterion requirement, and wherein said compounding nucleotide should meet of the present invention wanting simultaneously Ask.Additionally, described compounding nucleotide, premix also can compound voluntarily.The present invention is only for convenience of statement Use " compounding ", be not meant in compound that each component must first mix and reapply.Each raw material all should be Meet to add under relevant laws and regulations premise and use.
On the other hand, present invention also offers and a kind of prepare the described breast milk 0-12 month baby containing nucleotide and join The method of side's milk powder, its technological process prepared specifically include that dispensing, homogenizing, concentrating sterilizing, be spray-dried, dry Mix and obtain finished product.Specifically, the breast milk 0-12 month infant formula containing nucleotide described in the preparation of the present invention The method of milk powder includes:
Dispensing: by formula milk raw material except spray carrier (phospholipid and anhydrous butter oil) and rear batch mixing (DHA, ARA, Lactoferrin, bacillus bifidus) outer other raw materials mix, and obtain mixed liquor；
Homogenizing: mixed liquor carries out homogenizing；
Concentrating sterilizing: the feed liquid after homogenizing carries out concentrating sterilizing, concentrating sterilizing condition is: economic benefits and social benefits concentrate, sterilization temperature >=83 DEG C, sterilizing time 15～30 seconds, and to control discharge concentration be 48%～52% dry；
It is spray-dried: the preheated device of dense milk is preheating to 60～70 DEG C, and after preheating, material is through the mistake in 0.8～1.2mm aperture After filter filters, squeezing into drying tower and be spray-dried, controlling spray drying condition is: inlet temperature 165～180 DEG C, row Air temperature 75-90 DEG C, high-pressure pump pressure 160～210bar, tower negative pressure-4～-2mbar；
Fluid bed drying cools down: from drying tower powder out again after one-level fluid bed redrying, through secondary streams bed It is cooled to 25～30 DEG C, simultaneously under compressed air effect, will warm up the phospholipid (lecithin and/or big of 60～65 DEG C Fabaceous lecithin) evenly spread to powder surface with the mixture of carrier (anhydrous butter oil), obtain powder particles；
Rear batch mixing: DHA, ARA, lactoferrin, powder particles after bacillus bifidus and fluid bed drying cool down are done Dark equal, packaging, obtain milk powder finished product.
According to specific embodiments of the present invention, the breast milk 0-12 month formulated infant milk containing nucleotide of the present invention In the preparation method of powder, nutrient order of addition and stirring and dissolving time are also very important, it is preferable that during dispensing, Calcium powder, vitamin and nucleotide, mineral are to be sequentially added in other mixed powders and fuel mixture, and add Add after calcium powder stirring and dissolving 15～25 minutes, add after vitamin and nucleotide stirring and dissolving 15～20 minutes, add ore deposit Stirring and dissolving 15～20 minutes after material.Inventor finds under study for action, first adds calcium powder, and calcium can be with milk protein In casein combine and form colloid calcium, therefore can avoid or weaken the precipitation of calcium, but this cohesive process needs Time enough.If calcium adds with mineral simultaneously simultaneously, calcium powder can promote it with absorbed portion mineral such as ferrum Being become ferric iron from ferrous iron, ferric iron is red, therefore easily causes the precipitation of yellow to red.Next adds vitamin With compounding nucleotide, it is therefore an objective to containing the composition such as VC easily aoxidized by metal ion in vitamin, if being initially charged ore deposit Material, can be too high and cause the loss of vitamin due to the vitamine concentration of local.And if VC localized rich spends Height, can accelerate ferrous oxidation.It is eventually adding mineral to be because mineral and be dispersed in water slower than vitamin, with Time in mineral dispersive process, moisture film to be formed at its particle surface and just can stabilize it, and will not be to milk egg Produce destruction in vain, between this process needs are enough.Mineral fully and is added after milk mixed diluting Deng vitamin, The mineral loss to vitamin can be weakened.
According to specific embodiments of the present invention, the breast milk 0-12 month formulated infant milk containing nucleotide of the present invention In the preparation method of powder, described blending process includes:
Powder class is added: various powder class raw materials are joined in powder tank by unified the joining of blast system after metering by formula, and Sucked in Vacuum Mixture tank by vacuum system；
Dissolving and join oil: put between carburetion by recipe requirements by the oils and fats specified in formula, the temperature between carburetion is maintained at 50～90 DEG C, after oil soluble, squeeze in miscella basin, and by recipe requirements, miscella is squeezed into batch mixing through oil pump In tank；
Nutrient dissolves and adds: after calcium powder, vitamin and nucleotide, mineral pure water being dissolved respectively, sequentially Add in mixing tank, obtain the feed liquid of mixing.
In a specific embodiments of the present invention, the breast milk 0-12 month infant formula containing nucleotide of the present invention The preparation method of milk powder is carried out according to following operation:
1) powder class is added: various powder class raw materials are joined in powder tank by unified the joining of blast system after metering by formula Storage.
2) vacuum inhales powder: the various powder class raw materials joining in powder tank are sucked in Vacuum Mixture tank by vacuum system.
3) dissolve and join oil: putting between carburetion by recipe requirements by the oils and fats specified in formula, the temperature between carburetion should be protected Hold at 50～90 DEG C, after oil soluble, squeezed in miscella basin by oil pump and effusion meter by formula proportion requirement.
Mixing oil plant storage: miscella is insulation storage in oil hold-up tank, temperature 40～50 DEG C, period of storage is less than 12 Hour prevent fat oxidation.
4) weigh: by recipe requirements, miscella is squeezed into mixing tank through oil pump.
5) nutrient dissolves and adds: calcium powder, mineral, vitamin and nucleotide etc. add, respectively with 100～200kg Pure water, after dissolving respectively, squeezes into wet mixing cylinder, and every dozen of complete one 100kg pure water rinse and add tank and pipeline.
6) filter: blended feed liquid, through strainer filtering, removes the physical impurity may brought in raw material.
7) homogenizing: mixed feed liquid carries out homogenizing by homogenizer, homogenizing first class pressure is 105 ± 5bar, homogenizing First class pressure is 32 ± 3bar, and Oil globule is carried out mechanical treatment, and they are dispersed into the Oil globule of uniformity.
8) cool down and store: the feed liquid after homogenizing enters plate type heat exchanger and cools down: be cooled to less than 20 DEG C, temporarily Existing prestores in cylinder, enters next procedure in 6 hours, and agitator is opened by setting demand.
9) concentrating sterilizing: use economic benefits and social benefits to concentrate during production, sterilization temperature >=83 DEG C, sterilizing time 25 seconds.Discharging is dense Degree is 48%～52% dry.
10) dense milk storage, preheating are filtered, are spray-dried: the milk after concentration is temporarily stored in dense milk compensator.Pre-through scraper plate Hot device is preheating to 60～70 DEG C, and after preheating, material is after the filter in 1mm aperture filters, and squeezes into dry with high-pressure pump Tower is spray-dried, and fine powder is on request in tower top or fluidized bed agglomeration.Inlet temperature: 165～180 DEG C, temperature of outgoing air 75-90 DEG C, high-pressure pump pressure 160～210bar, tower negative pressure-4～-2mbar.
11) fluid bed drying cooling: from drying tower powder out again after fluid bed (one-level) redrying, through stream Change bed (two grades) and be cooled to 25～30 DEG C.Simultaneously phospholipid with carrier mixing post-heating to 60～65 DEG C, in compressed air Under effect, evenly spread to powder surface, make powder particles agglomeration increase its granularity and instant capacity.
12) subpackage: powder process plant personnel is according to recipe requirements, by DHA, ARA, lactoferrin or bacillus bifidus Weigh envelope subpackage.
13) it is dry mixed: load weighted DHA, ARA, lactoferrin or bacillus bifidus are mixed in dry-mixed machine with milk powder All.
14) sieve powder: by vibrosieve, making the uniform granularity of milk powder, granulated slag scraps process.
15) powder delivery: connect powder with the collection powder case through sterilization, and by being transported between powder delivery between upper powder.
16) upper powder: milk powder is poured in the storage powder tank on big small packer by packing instructions.
17) packaging: 400 grams of automatic packaging machine nitrogen gas packing.During nitrogen charging, oxygen content is less than 1%.900 grams of ferrum are listened automatically Nitrogen gas packing oxygen content is less than 5%.
18) vanning: the pouch packed is loaded in carton and is simultaneously introduced powder spoon, seal with cartoning sealing machine.
19) product inspection: the product after having packed is sampled inspection by inspection plan.
20) warehouse-in storage: through the product warehousing storage that inspection is qualified, it is desirable to store at normal temperatures, humidity≤65%.
For Zong He, the invention provides a kind of breast milk 0-12 month babies ' formula milk powder containing nucleotide and system thereof Preparation Method, the lactoprotein of the babies ' formula milk powder of the present invention, fat, nucleotide composition and ratio etc. closer to breast milk, Feeding effect, also closer to breast milk, is more suitable for Asia baby particularly Chinese (Chinese) baby, can promote baby The immunity of youngster.
Detailed description of the invention
Implementation process and the beneficial effect of generation of the present invention is described in detail, it is intended to help to read below by way of specific embodiment Reader is more fully understood that essence and the feature of the present invention, not as can the restriction of practical range to this case.The following example In the method for unreceipted actual conditions, generally carry out according to the routine operation of art.
Embodiment 1
Breast milk 0-12 month babies ' formula milk powder (preparing 1000 kilograms) containing nucleotide:
Lactose 425 kilograms, whole milk powder 190 kilograms, lactalbumin powder WPC80%40 kilogram, desalted whey powder D9025 kilogram, 140 kilograms of parts of Oleum Helianthi, Semen Maydis oil 20 kilograms, soybean oil 60 kilograms, alpha lactalbumin 30 kilograms of powder, 9 kilograms of beta-casein powder, compounding 0.54 kilogram of nucleotide, 2 kilograms of lecithin, anhydrous butter oil 1 Kilogram, oligofructose powder 17 kilograms, 40 kilograms of oligomeric galactose slurry, premix 14 kilograms, DHA 8,000 Gram, ARA 8.2 kilograms, lactoferrin 0.45 kilogram, bacillus bifidus 0.2 kilogram.
Wherein 0.54 kilogram of compounding nucleotide each nucleotide effective ingredient is as follows: CMP:229..68g, AMP:46.9g, UMP:63.0g, GMP:46.9g.In compounding nucleotide in addition to the hydrate or salt of each nucleotide, remaining is breast Sugar.
Wherein premix include compounding vitamin bag about 2.5 kilograms, choline chloride nutrient pack about 0.75 kilogram, Calcium powder nutrient pack about 6 kilograms, mineral matter nutritional bag about 1 kilogram and magnesium chloride and potassium chloride nutrient pack, each nutrient pack Base material be lactose, concrete main nutrients composition is as follows: 1) compound vitamin, in every gram of compounding vitamin, Taurine: 190mg；Vitamin A (retinol acetate): 2000 μ gRE；Vitamin D (cholecalciferol): 40 μ g； Vitamin B1 (thiamine nitrate): 3400 μ g；Vitamin B2 (riboflavin): 900 μ g；Vitamin B6 (salt Acid pyridoxol): 2000 μ g；Vitamin B12 (cobalamin): 10.0 μ g；Vitamin K1 (phytonadione): 390μg；Vitamin C (L-AA): 570mg；Vitamin E (dl-α-tocopheryl acetate): 29mg α-TE； Nicotiamide: 20000 μ g；Folic acid: 500 μ g；Biotin (Bio): 90 μ g；Pantothenic acid (D-VB5 calcium): 14000μg；Phylloxanthin: 260 μ g；2) calcium powder, in every gram of calcium powder, calcium (calcium carbonate, tricalcium phosphate): 180mg； Phosphorus (tricalcium phosphate): 90mg；3) mineral, in every gram of mineral, ferrum (ferrous sulfate): 60mg；Zinc (sulfur Acid zinc): 40mg；Copper (copper sulfate): 4000 μ g；Iodine (potassium iodide): 900 μ g；Selenium (sodium selenite): 160μg；Manganese (manganese sulfate): 500 μ g；4) magnesium chloride, in every 1000 kilograms of milk powder, magnesium (magnesium chloride): 150g； 5) potassium chloride, in every 1000 kilograms of milk powder, potassium (potassium chloride): 1050g；6) choline chloride, every 1,000,000 In gram milk powder, choline (choline chloride): 700g.
Linoleic acid and the content of alpha-linolenic acid in the most raw materials used Oleum Helianthi, Semen Maydis oil, soybean oil are respectively 8.20%, 0.3%, 55.50%, 1.2%, 52.10%, 8.8%.
Containing nucleotide, the breast milk concrete preparation technology of infants formula milk is as follows:
1) powder class is added: various powder class raw materials are joined in powder tank by unified the joining of blast system after metering by formula Storage.
2) vacuum inhales powder: the various powder class raw materials joining in powder tank are sucked in Vacuum Mixture tank by vacuum system.
3) dissolve and join oil: putting between carburetion by recipe requirements by the oils and fats specified in formula, the temperature between carburetion should be protected Hold at 60 DEG C, after oil soluble, squeezed in miscella basin by oil pump and effusion meter by formula proportion requirement.
4) weigh: by recipe requirements by miscella in mixing tank squeezed into by oil pump.
5) nutrient dissolves and adds: calcium powder, mineral, vitamin and nucleotide etc. add respectively, pure with 150kg Water purification, after dissolving respectively, squeezes in mixing tank, and every dozen of complete one 100kg pure water rinse and add tank and pipeline.
6) filter: blended feed liquid, through strainer filtering, removes the physical impurity may brought in raw material.
7) homogenizing: mixed feed liquid carries out homogenizing by homogenizer, carries out mechanical treatment by Oil globule, them It is dispersed into the Oil globule of uniformity.
8) cool down and store: the feed liquid after homogenizing enters plate type heat exchanger and cools down: be cooled to less than 20 DEG C, temporarily Existing prestores in cylinder, enters next procedure in 6 hours, and agitator is opened by setting demand.
9) concentrating sterilizing: use economic benefits and social benefits to concentrate during production, sterilization temperature >=83 DEG C, sterilizing time 25 seconds.Discharging is dense Degree is 50% dry.
10) dense milk storage, preheating are filtered, are spray-dried: the milk after concentration is temporarily stored in dense milk compensator.Pre-through scraper plate Hot device is preheating to 60 DEG C, and after preheating, material is after the filter in 1mm aperture filters, and squeezes into drying tower spray with high-pressure pump Mist is dried, and fine powder is on request in tower top or fluidized bed agglomeration.Inlet temperature: 180 DEG C, temperature of outgoing air 86 DEG C, high pressure Pump pressure 200bar, tower negative pressure about-4mbar.
11) fluid bed drying cooling: from drying tower powder out again after fluid bed (one-level) redrying, through stream Change bed (two grades) and be cooled to 30 DEG C.Simultaneously lecithin with carrier mixing post-heating to 60 DEG C, in compressed air effect Under, evenly spread to powder surface, make powder particles agglomeration increase its granularity and instant capacity.
12) subpackage: powder process plant personnel is according to recipe requirements, by DHA, ARA, lactoferrin or bacillus bifidus Weigh envelope subpackage.
13) it is dry mixed: load weighted DHA, ARA, lactoferrin or bacillus bifidus are mixed in dry-mixed machine with milk powder All.
14) sieve powder: by vibrosieve, making the uniform granularity of milk powder, granulated slag scraps process.
15) powder delivery: connect powder with the collection powder case through sterilization, and by being transported between powder delivery between upper powder.
16) upper powder: milk powder is poured in the storage powder tank on big small packer by packing instructions.
17) packaging: 400 grams of automatic packaging machine nitrogen gas packing.During nitrogen charging, oxygen content is less than 1%.900 grams of ferrum are listened automatically Nitrogen gas packing oxygen content is less than 5%.
18) vanning: the pouch packed is loaded in carton and is simultaneously introduced powder spoon, seal with cartoning sealing machine.
19) product inspection: the product after having packed is sampled inspection by inspection plan.
20) warehouse-in storage: through the product warehousing storage that inspection is qualified, it is desirable to store at normal temperatures, humidity≤65%.
Embodiment 2
(preparing 1000 kilograms) containing nucleotide breast milk infants formula milk formula:
Lactose 350 kilograms, whole milk powder 150 kilograms, defatted milk powder 225 kilograms, lactalbumin powder WPC80% 20 kilograms, desalted whey powder D9025 kilogram, Oleum Helianthi 85 kilograms, Semen Maydis oil 20 kilograms, soybean oil 50 kilograms, 4 kilograms of alpha lactalbumin powder, 1 kilogram of beta-casein powder, compounding 0.57 kilogram of nucleotide, Semen sojae atricolor phosphorus 2 kilograms of fat, anhydrous butter oil 1 kilogram, oligofructose powder 6 kilograms, oligomeric galactose is starched 14 kilograms, is compounded nutrition Element 13.7 kilograms, DHA 7 kilograms, ARA 8 kilograms, lactoferrin 0.5 kilogram, bacillus bifidus 0.18 kilogram.
Wherein 0.57 kilogram of compounding nucleotide each nucleotide effective ingredient is as follows: CMP:230.43g, AMP:47.75g, UMP:64.06g, GMP:47.75g.In compounding nucleotide in addition to the hydrate or salt of each nucleotide, remaining is Lactose.
Wherein premix include compounding vitamin bag about 2.5 kilograms, choline chloride nutrient pack about 0.4 kilogram, Calcium powder nutrient pack about 6.5 kilograms, mineral matter nutritional bag about 1.8 kilograms and magnesium chloride and potassium chloride nutrient pack, respectively seek The base material supporting bag is lactose, and concrete main nutrients composition is as follows: 1) compounding vitamin, every gram of compounding vitamin In, taurine: 200mg；Vitamin A (retinol acetate): 2000 μ gRE；Vitamin D (cholecalciferol): 40μg；Vitamin B1 (thiamine nitrate): 3600 μ g；Vitamin B2 (riboflavin): 990 μ g；Vitamin B6 (pyridoxine hydrochloride): 1800 μ g；Vitamin B12 (cobalamin): 10.0 μ g；Vitamin K1 (plant first Naphthoquinone): 380 μ g；Vitamin C (L-AA): 500mg；Vitamin E (dl-α-tocopheryl acetate): 30mgα-TE；Nicotiamide: 20000 μ g；Folic acid: 450 μ g；Biotin (Bio): 80 μ g；Pantothenic acid (D- Calcium pantothenate): 12000 μ g；Phylloxanthin: 950 μ g；2) calcium powder, in every gram of calcium powder, calcium (calcium carbonate, tricresyl phosphate Calcium): 250mg；Phosphorus (tricalcium phosphate): 75mg；3) mineral, in every gram of mineral, ferrum (ferrous sulfate): 69mg；Zinc (zinc sulfate): 33mg；Copper (copper sulfate): 3800 μ g；Iodine (potassium iodide): 750 μ g；Selenium (sodium selenite): 160 μ g；4) magnesium chloride, in every 1000 kilograms of milk powder, magnesium (magnesium chloride): 100g；5) Potassium chloride, in every 1000 kilograms of milk powder, potassium (potassium chloride): 950g；6) choline chloride, every 1000 kilograms of milk In powder, choline (choline chloride): 350g.
Linoleic acid and the content of alpha-linolenic acid in the most raw materials used Oleum Helianthi, Semen Maydis oil, soybean oil are respectively 8.20%, 0.3%, 55.50%, 1.2%, 52.10%, 8.8%.
Containing nucleotide, the breast milk concrete preparation technology of infants formula milk is as follows:
1) powder class is added: various powder class raw materials are joined in powder tank by unified the joining of blast system after metering by formula Storage.
2) vacuum inhales powder: the various powder class raw materials joining in powder tank are sucked in Vacuum Mixture tank by vacuum system.
3) dissolve and join oil: putting between carburetion by recipe requirements by the oils and fats specified in formula, the temperature between carburetion should be protected Hold at 60 DEG C, after oil soluble, squeezed in miscella basin by oil pump and effusion meter by formula proportion requirement.
4) weigh: by recipe requirements by miscella in mixing tank squeezed into by oil pump.
5) nutrient dissolves and adds: calcium powder, mineral, vitamin and nucleotide etc. add respectively, use 150kg Pure water, after dissolving respectively, squeezes in mixing tank, and every dozen of complete one 100kg pure water rinse and add tank and pipe Line.
6) filter: blended feed liquid, through strainer filtering, removes the physical impurity may brought in raw material.
7) homogenizing: mixed feed liquid carries out homogenizing by homogenizer, carries out mechanical treatment by Oil globule, them It is dispersed into the Oil globule of uniformity.
8) cool down and store: the feed liquid after homogenizing enters plate type heat exchanger and cools down: be cooled to less than 20 DEG C, temporarily Existing prestores in cylinder, enters next procedure in 6 hours, and agitator is opened by setting demand.
9) concentrating sterilizing: use economic benefits and social benefits to concentrate during production, sterilization temperature >=83 DEG C, sterilizing time 25 seconds.Discharging is dense Degree is 50% dry.
10) dense milk storage, preheating are filtered, are spray-dried: the milk after concentration is temporarily stored in dense milk compensator.Pre-through scraper plate Hot device is preheating to 60 DEG C, and after preheating, material is after the filter in 1mm aperture filters, and squeezes into drying tower spray with high-pressure pump Mist is dried, and fine powder is on request in tower top or fluidized bed agglomeration.Inlet temperature: 180 DEG C, temperature of outgoing air 86 DEG C, high-pressure pump Pressure 200bar, tower negative pressure about-4mbar.
11) fluid bed drying cooling: from drying tower powder out again after fluid bed (one-level) redrying, through stream Change bed (two grades) and be cooled to 30 DEG C.Soybean phospholipid is with carrier mixing post-heating to 60 DEG C simultaneously, makees in compressed air Under with, evenly spread to powder surface, make powder particles agglomeration increase its granularity and instant capacity.
12) subpackage: powder process plant personnel is according to recipe requirements, by DHA, ARA, lactoferrin or bacillus bifidus Weigh envelope subpackage.
13) it is dry mixed: load weighted DHA, ARA, lactoferrin or bacillus bifidus are mixed in dry-mixed machine with milk powder All.
14) sieve powder: by vibrosieve, making the uniform granularity of milk powder, granulated slag scraps process.
15) powder delivery: connect powder with the collection powder case through sterilization, and by being transported between powder delivery between upper powder.
16) upper powder: milk powder is poured in the storage powder tank on big small packer by packing instructions.
17) packaging: 400 grams of automatic packaging machine nitrogen gas packing.During nitrogen charging, oxygen content is less than 1%.900 grams of ferrum are listened automatically Nitrogen gas packing oxygen content is less than 5%.
18) vanning: the pouch packed is loaded in carton and is simultaneously introduced powder spoon, seal with cartoning sealing machine.
19) product inspection: the product after having packed is sampled inspection by inspection plan.
20) warehouse-in storage: through the product warehousing storage that inspection is qualified, it is desirable to store at normal temperatures, humidity≤65%.
The detection of each embodiment quality of milk powder and feeding trial
Embodiments of the invention 1,2 containing nucleotide breast milk infants formula milk and Chinese's (Chinese) breast milk and The detection Data Comparison of two kinds of commercial infant milk powder is shown in Table 1, and (wherein, Chinese (Chinese) breast milk is to gather whole nation weight 300 parts of mean values detected respectively of female ripe breast in the 15 days puerperal～12 months of some Hans):
Table 1
Note: each powdered milk sample reconstitutes the ratio for milk and is: the milk powder of embodiment 1 13.2 grams adds water and reconstitutes to 100ml Milk；The milk powder 14.1g of embodiment 2 adds water and reconstitutes to 100ml milk；Two kinds of commercial infant milk powder 13.2 grams adds water Reconstitute to 100ml milk.
The babies ' formula milk powder of table 2 present invention contrasts table with breast milk amino acid structure
The forming in albumen, fat segmentation containing nucleotide breast milk infants formula milk of the present invention as can be seen from Table 2 And close with Chinese (Chinese) breast milk in nucleotide total amount and monomer ratio, and commercially available babies ' formula milk powder with Breast milk difference is bigger.Because the present inventor has taken into full account albumen, fat, nucleotide in each raw material of making formula powder Content, on the basis of its background concentration, particularly enhance various nucleotide monomer so that it is each albumen in finished product, Fat, nucleotide monomer content closer to Chinese (Chinese) breast milk, therefore, the present invention containing nucleotide breast milk Infants formula milk is sent out than commercially available interpolation nucleotide babies ' formula milk powder, immune system and gastrointestinal tract to infant Give birth to important meaning.
Comparative result is tried out in babies ' formula milk powder of the present invention and commercially available prod:
The present inventor selects 90 people, age 0～12 months, of the present invention group of 60 people, the another 30 commercially available formula milks of people at random Group, tries out babies ' formula milk powder of the present invention with commercially available prod after two weeks, and statistics constipation and diarrhoea situation occurs during trying out The results are shown in Table 3:
Table 3
Constipation number Diarrhoea number
The embodiment of the present invention 1 group (30 people) 0 1
The embodiment of the present invention 2 groups (30 people) 0 1
Marketed formulation group (30 people) 7 2
Breast milk group (10 people) 0 2
As can be seen from the above table during two weeks tried out, the formula milk of edible of the present invention group occurs without constipation, in have 1 people suffers from diarrhoea, and edible commercially available dried milk powder group has 7 people that constipation occurs, and 2 people suffer from diarrhoea, the formulas of the present invention Powder is suitable with breast feeding effect.
The immune effect test of different ratio nucleotide
This test be intended to confirm the present invention milk powder in each nucleotide proportion effect in terms of immunostimulation, its principle and Step sees regulation and the requirement of " health food inspection and assessment technique specification (version in 2003) " Part II chapter 1.
1. materials and methods
1.1. main agents
Main agents used in this test has: RPMI-1640 culture medium (Gibco)；Hyclone (Gibco)；ConA (Sigma) (Chinese is entitled: concanavalin A, Con A)；Lymphocyte separation medium, whole blood and tissue diluent, cell washing solution (Hao ocean, Tianjin biological product science and technology limited Company)；5% chicken erythrocyte suspension (prepared by laboratory)；MTT reagent Box, Hank's liquid (green skies biotechnology research institute)；Giemsa dye liquor (Beisuo Biological Technology Co., Ltd., Zhuhai)； EDTA anticoagulant tube (BD)；96 porocyte culture plates (Corning)；(positive biological section is inspired confidence in Shanghai hundred in board cattle colostrums capsule Skill company limited)；Nucleotide sample (Nanjing is with triumphant million industry).Without specializing, agents useful for same and equipment here It is purchased from (green skies biotechnology research institute).
1.2. key instrument equipment
CO2Incubator (Sanyo MCO-18AIC (UV))；Superclean bench (AIRTECH)；Inverted microscope (OLYMPUS)；Hitachi's horizontal centrifuge (himac-CT6EL)；Microplate reader (BIO-RAD Model 680)； OLYMPUS microscope (BX51)；DNP constant incubator (above Nereid's grand experimental facilities company limited).
1.3. laboratory animal
5～6 week old male KM mices 160, are provided by Shanghai Slac Experimental Animal Co., Ltd..
1.4. animal packet
After making KM mice adaptability raise 7 days, be randomly divided into 8 groups, often group 20, i.e. blank group, Positive controls, the high, medium and low dosage group of sample one and compare the high, medium and low dosage group of sample.To often group Animal gavage respectively has dissolved the sterilized water of each sample (seeing below), the sterilized water of blank group gavage same volume. Every day 1 time, feed continuously or gavage 30 days.
The dosage fed of high dose group is 67.37mg kg-1D-1, the dosage of middle dosage group is 41.82mg kg-1 D-1, the dosage of low dose group is 23.23mg kg-1D-1.The dosage of positive controls is (150.17mg kg-1 D-1)。
Positive controls: cattle colostrums capsule.
Experimental group:
Sample one: with reference to the compounding polynucleotide composition of embodiment of the present invention milk powder nucleotide content, it forms and joins It is CMP:60%, AMP:12%, UMP:16% and GMP:12% than (by weight).
Relatively sample: this sample is to add nucleotide group used in the infant food of nucleotide according to certain commercially available money Point and the polynucleotide composition prepared of proportioning, its composition and proportioning (by weight) be CMP:33.7%, AMP 20.3%, UMP 23.1%, GMP 7.6% and IMP 15.3%.
1.5. Testing index
Lymphocyte transformation is tested:Each group in experiment the 38th day, takes 10 mices at random, uses 2mL EDTA Anticoagulant tube, extracts eyeball blood sampling, uses Ficoll density－gradient centrifuga－tion method, aseptic separation lymphocyte.Take 1mL Fresh anticoagulation, mixes it with 1:1 with whole blood and tissue diluent, is the most carefully added on equal-volume lymphocyte and divides On the liquid level of chaotropic.It is centrifuged 15 minutes with 1500 revs/min with horizontal centrifuge, collects ring-type milky lymph thin Born of the same parents' layer, washs it 2 times with cell washing solution.It is formulated as 1 × 10 with RPMI-1640 complete culture solution7Individual/mL, Being subsequently adding 96 porocyte culture plates, every hole 100 μ L, every Mus 6 hole, wherein 3 holes addition ConA are (final concentration of 5 μ g/mL), another 3 holes are not added with as comparison.At 5%CO2With the CO of 37 DEG C2After incubator is cultivated 68 hours, Adding MTT (5mg/mL) solution (10 μ L/ hole), after continuing to cultivate 4 hours, every hole adds 100 μ L Formazan (Chinese is entitled: first) solution, then at the CO of 37 DEG C2Continue in incubator to hatch, until observing Formazan All dissolve.Microplate reader measures OD value with wavelength 570nm, calculates stimulation index (SI): SI=ConA and sting Swash pipe OD meansigma methods/control tube OD meansigma methods.
Peritoneal macrophage phagocytosis experiment:Each group, in experiment the 38th day, takes 10 mices, every Mus lumbar injection at random 5% chicken erythrocyte suspension 1mL.After 30 minutes, put to death mice with cervical dislocation.Intraperitoneal injection lmL physiology salt Water, gently rubs mouse web portion 1 minute, cuts off abdominal skin, in Musclar layer upper shed, stretches into abdominal cavity with suction pipe and draws abdomen Chamber liquid lmL, drips on clean microscope slide.Microscope slide is put in the enamel box being lined with wet gauze, then put Enter 37 DEG C of incubators and hatch 30 minutes.Taking out microscope slide, supernatant and nonadherent cell on slide are removed in rinsing, The most at room temperature dry, with 1:1 acetone/methanol solution fixing after, be placed in Giemsa dyeing liquor, contaminate 15～ 30 minutes, then wash and dry.Counting macrophage under high power lens, every slide counts 100, respectively Calculate phagocytic percentage and phagocytic index.
1.6. statistical analysis
Data all withRepresent, use SPSS 13.0 statistical software that data are carried out variance analysis, compare two-by-two and adopt Using snk method, inspection level is α=0.05.
2. result
2.1. the sample impact on the proliferative function of lymphocyte
Table 4 sample on the impact of mouse lymphocyte expanding capacity (N=10)
Group Stimulation index (SI)
Blank group 1.24±0.19
Positive controls 2.13±0.47*
Sample one high dose group 2.09±0.23*
Dosage group in sample one 1.87±0.26*
Sample one low dose group 1.46±0.34*
Relatively sample high dose group 1.51±0.18*
Relatively dosage group in sample 1.30±0.22
Relatively sample low dose group 1.27±0.15
Note:*Significant difference (p < 0.05) compared with blank group.
From table 4, the SI value of the high, medium and low dosage group of sample one is all remarkably higher than blank group (p < 0.05), And in dose dependent；The relatively SI value of the high dose group of sample is significantly higher than blank group (p < 0.05), compares In sample, low dose group SI value and blank group difference notable (p > 0.05)；The low dose group of sample one SI value is significantly higher than and compares dosage group in sample (p < 0.05).
Result above shows that the oligonucleotide ligand ratio in the milk powder of the present invention is remarkably improved mouse lymphocyte expanding capacity, And effect is better than comparing sample.
2.2. the sample impact on macrophage phagocytic function
Table 5 sample on the impact of macrophage phagocytosis of mice (N=10)
Group Phagocytic percentage (%) Phagocytic index
Blank group 35.2±4.2 0.43±0.06
Positive controls 52.7±8.6* 0.62±0.10*
Sample one high dose group 50.1±2.5* 0.59±0.01*
Dosage group in sample one 48.7±3.2* 0.57±0.13*
Sample one low dose group 46.7±3.1* 0.53±0.07*
Relatively sample high dose group 49.8±2.0* 0.50±0.22*
Relatively dosage group in sample 34.9±1.7 0.44±0.12
Relatively sample low dose group 35.1±3.9 0.42±0.19
Note:*Significant difference (p < 0.05) compared with blank group.
From table 5, phagocytic percentage and the phagocytic index of the high, medium and low dosage group of sample one are all remarkably higher than sky White matched group (p < 0.05)；Relatively phagocytic percentage and the phagocytic index of the high dose group of sample is significantly higher than blank Group (p < 0.05), compare in sample, the phagocytic percentage of low dose group and phagocytic index with blank group difference not Significantly (p > 0.05)；The phagocytic percentage of the low dose group of sample one and phagocytic index are significantly higher than the middle agent comparing sample Amount group (p < 0.05).
Result above shows that the oligonucleotide ligand ratio in the milk powder of the present invention is remarkably improved Turnover of Mouse Peritoneal Macrophages phagocytosis Function, and effect is better than comparing sample.
3. conclusion
From the above experimental results, the oligonucleotide ligand ratio in the milk powder of the present invention is remarkably improved lymphocyte transformation merit Can, strengthen Peritoneal Macrophage Phagocytosis, there is the effect improving immunologic function, and immunoregulation effect is significantly high In comparing sample.

Claims (10)

1. the breast milk 0-12 month babies ' formula milk powder containing nucleotide, the total protein content in this milk powder is 10.5～18g/100g, it is 48～61% that lactalbumin accounts for the ratio of total protein, and alpha lactalbumin content is 1.25～1.8g/100g, beta-casein content is 2.2～3.7g/100g, lactoferrin content 35～60mg/100g, fat Content is 20～29g/100g, and linoleic acid content is 2600～4500mg/100g, and alpha-linolenic acid content is 350～450mg/100g, carbohydrate content is 52～56g/100g, and total nucleotide content is with nucleic acid molecule total amount It is calculated as 26～58mg/100g；Wherein:
The raw material providing lactoprotein includes one or more in basic material milk, whole milk powder, defatted milk powder, also Including: one or more in the raw material lactalbumin powder that adds for fortified milk albumin, desalted whey powder, for by force The raw material alpha lactalbumin powder changing alpha lactalbumin and add, the raw material beta-casein added for strengthening beta-casein Powder, and the raw milk ferritin added for fortified milk ferritin；
There is provided the raw material of fat in addition to the basic material containing butterfat, also include vegetable oil；
The raw material providing nucleotide includes that the raw material added for strengthening nucleotide compounds nucleotide.
Breast milk 0-12 month babies ' formula milk powder containing nucleotide the most according to claim 1, based on 1000 The described breast milk 0-12 month babies ' formula milk powder containing nucleotide of weight portion, wherein:
The raw material providing lactoprotein includes: whole milk powder 125～200 weight portion；Defatted milk powder 0～250 weight portion；Breast Albumin powder 30～210 weight portion；Desalted whey powder 10～50 weight portion；Alpha lactalbumin powder 4～35 weight portion；β- Casoid flour 0.5～10 weight portion；
There is provided the raw material of fat in addition to the basic material containing butterfat, also include: Oleum Helianthi 60～150 weight portion； Semen Maydis oil 10～30 weight portion；Soybean oil 30～90 weight portion；
There is provided the raw material of carbohydrate in addition to the basic material containing lactose, also include raw material lactose 300～450 weight Part；
The raw material providing nucleotide includes that the raw material added for strengthening nucleotide compounds nucleotide 0.45～0.65 weight Part, its nucleotide effective dose in terms of nucleic acid molecule total amount less than 0.58 weight portion, and, wherein IMP contains Amount is 0 or more than 0 and not higher than 2%.
Breast milk 0-12 month babies ' formula milk powder containing nucleotide the most according to claim 1 and 2, based on The described breast milk 0-12 month babies ' formula milk powder containing nucleotide of 1000 weight portions, its raw material also includes:
Comprise premix 9～15 weight portion of calcium powder, vitamin and mineral；
Breast milk 0-12 month babies ' formula milk powder containing nucleotide the most according to claim 1 and 2, wherein, In described compounding nucleotide, nucleotide effective content is calculated as 599～750mg/g with nucleic acid molecule total amount, and, its Middle IMP content is 0 or more than 0 and not higher than 2%.
Breast milk 0-12 month babies ' formula milk powder containing nucleotide the most according to claim 1 and 2, wherein, In described compounding nucleotide, each nucleotide effective content is scored with CMP, AMP, UMP, GMP, IMP molecule It is not:
CMP:365～430mg/g；
UMP:94～120mg/g；
GMP:70～90mg/g；
AMP:70～90mg/g；
IMP:0, or more than 0 and not higher than 20mg/g.
6. according to the breast milk 0-12 month babies ' formula milk powder containing nucleotide described in any one of Claims 1 to 5, Wherein, in described compounding nucleotide, it is converted to CMP, AMP, UMP, GMP, IMP molecule with each nucleotide The total amount of meter is 100%, and the effective percentage composition of each nucleotide is with CMP, AMP, UMP, GMP, IMP molecule Meter is respectively as follows: CMP 58～70%, and AMP 7.5～12.5%, UMP 12～16.5%, GMP 10～13%, IMP are 0 or more than 0 and not higher than 2.5%；It is preferably: CMP 59～65%, AMP 8～12.5%, UMP 14～16.5%, GMP 11～12.5%, IMP are 0 or more than 0 and not higher than 2%.
Breast milk 0-12 month babies ' formula milk powder containing nucleotide the most according to claim 1, wherein, institute Stating premix and at least include compounding vitamin, calcium powder, mineral, magnesium chloride and potassium chloride, each amounts of components is:
1) compounding vitamin, in every gram of compounding vitamin:
Vitamin A: 2000～3000 μ gRE
Vitamin D: 30～45 μ g
Vitamin B1: 2600～3600 μ g
Vitamin B2: 600～1000 μ g
Vitamin B6: 1650～2350 μ g
Vitamin B12: 9.1～12.0 μ g
Vitamin K: 325～430 μ g
Vitamin C: 500～720mg
Vitamin E: 28～39.1mg α-TE
Nicotiamide: 17900～24550 μ g
Folic acid: 428～553 μ g
Biotin: 66.9～98.1 μ g
Pantothenic acid: 11510～15230 μ g
Phylloxanthin: 240～1000 μ g
2) calcium powder, in every gram of calcium powder:
Calcium: 160～250mg
Phosphorus: 75～100mg
3) mineral, in every gram of mineral:
Ferrum: 40～85mg
Zinc: 33～49mg
Copper: 3800～4940 μ g
Iodine: 748～992 μ g
Selenium: 102～185 μ g
Manganese: 0～579 μ g
4) magnesium chloride, in every 1000 kilograms of milk powder:
Magnesium: 80～170g
5) potassium chloride, in every 1000 kilograms of milk powder:
Potassium: 950～1050g；
The addition of described bacillus bifidus is 0.1～0.2 weight portion.
8. the breast milk 0-12 month formulated infant milk containing nucleotide prepared described in any one of claim 1～7 The method of powder, the method includes:
Dispensing: other raw materials in addition to spray carrier and rear batch mixing in formula milk raw material are mixed, obtains compound Liquid；
Homogenizing: mixed liquor carries out homogenizing；
Concentrating sterilizing: the feed liquid after homogenizing carries out concentrating sterilizing, concentrating sterilizing condition is: economic benefits and social benefits concentrate, sterilization temperature >=83 DEG C, sterilizing time 15～30 seconds, and to control discharge concentration be 48%～52% dry；
It is spray-dried: the preheated device of dense milk is preheating to 60～70 DEG C, and after preheating, material is through the mistake in 0.8～1.2mm aperture After filter filters, squeezing into drying tower and be spray-dried, controlling spray drying condition is: inlet temperature 165～180 DEG C, row Air temperature 75-90 DEG C, high-pressure pump pressure 160～210bar, tower negative pressure-4～-2mbar；
Fluid bed drying cools down: from drying tower powder out again after one-level fluid bed redrying, through secondary streams bed Being cooled to 25～30 DEG C, simultaneously under compressed air effect, the spray carrier that will warm up 60～65 DEG C evenly spreads to Powder surface, obtains powder particles；
Rear batch mixing: the powder particles after being cooled down with fluid bed drying by rear batch mixing is dry mixed and is mixed, packaging, obtain milk powder finished product.
Method the most according to claim 8, wherein, during dispensing, calcium powder, vitamin and nucleotide, mineral Matter is to be sequentially added in other mixed powders and fuel mixture, and adds after calcium powder stirring and dissolving 15～25 points Clock, adds after vitamin and nucleotide stirring and dissolving 15～20 minutes, adds after mineral stirring and dissolving 15～20 minutes, Mixing speed is 600～800 turns.
Method the most according to claim 8 or claim 9, wherein, described blending process includes:
Powder class is added: various powder class raw materials are joined in powder tank by unified the joining of blast system after metering by formula, and Sucked in Vacuum Mixture tank by vacuum system；
Dissolving and join oil: put between carburetion by recipe requirements by the oils and fats specified in formula, the temperature between carburetion is maintained at 50～90 DEG C, after oil soluble, squeeze in miscella basin, and by recipe requirements, miscella is squeezed into batch mixing through oil pump In tank；
Nutrient dissolves and adds: after calcium powder, vitamin and nucleotide, mineral pure water being dissolved respectively, sequentially Add in mixing tank, obtain the feed liquid of mixing.
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CN107125323A (en) * 2017-07-17 2017-09-05 湖南贝恩叮当猫婴童用品有限公司 A kind of production technology of baby milk powder
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CN107897380A (en) * 2017-12-12 2018-04-13 河北三元食品有限公司 A kind of close to breast milk and have the function of prebiotic babies ' formula milk powder of enteron aisle and preparation method thereof
CN107927198A (en) * 2017-12-19 2018-04-20 光明乳业股份有限公司 One kind drinks milk powder and preparation method thereof for premature
CN111194925A (en) * 2018-11-19 2020-05-26 临沂山松药业有限公司 Total-nutrient special medical application formula food containing soybean peptide and preparation method thereof
CN109662150A (en) * 2018-12-26 2019-04-23 光明乳业股份有限公司 A kind of breast milk protein compositions and the babies ' formula milk powder containing it
CN111227044A (en) * 2019-11-20 2020-06-05 内蒙古伊利实业集团股份有限公司 Dairy product, preparation method and medical application thereof
CN111227044B (en) * 2019-11-20 2023-05-16 内蒙古伊利实业集团股份有限公司 Dairy product, preparation method and medical application thereof
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CN115644430A (en) * 2022-11-30 2023-01-31 内蒙古伊利实业集团股份有限公司 Milk protein deep-hydrolyzed infant formula containing breast milk oligosaccharide LNnT
CN115769841A (en) * 2022-11-30 2023-03-10 内蒙古伊利实业集团股份有限公司 Formula milk powder and preparation method thereof
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