CN106236645A - A kind of natural child's collutory - Google Patents
A kind of natural child's collutory Download PDFInfo
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- CN106236645A CN106236645A CN201610737399.0A CN201610737399A CN106236645A CN 106236645 A CN106236645 A CN 106236645A CN 201610737399 A CN201610737399 A CN 201610737399A CN 106236645 A CN106236645 A CN 106236645A
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- 239000003814 drug Substances 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 239000000796 flavoring agent Substances 0.000 claims abstract description 6
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 6
- 239000003086 colorant Substances 0.000 claims abstract description 5
- 239000004094 surface-active agent Substances 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 3
- 230000002335 preservative effect Effects 0.000 claims abstract description 3
- 241000345998 Calamus manan Species 0.000 claims description 14
- 235000012950 rattan cane Nutrition 0.000 claims description 14
- 241000722913 Callistephus chinensis Species 0.000 claims description 13
- 240000006497 Dianthus caryophyllus Species 0.000 claims description 13
- 235000009355 Dianthus caryophyllus Nutrition 0.000 claims description 13
- 240000001436 Antirrhinum majus Species 0.000 claims description 12
- 240000003307 Zinnia violacea Species 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 11
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical group [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- 241000207199 Citrus Species 0.000 claims description 3
- 240000000249 Morus alba Species 0.000 claims description 3
- 235000008708 Morus alba Nutrition 0.000 claims description 3
- 235000020971 citrus fruits Nutrition 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N 1-dodecanol group Chemical group C(CCCCCCCCCCC)O LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 1
- 235000011158 Prunus mume Nutrition 0.000 claims 1
- 244000018795 Prunus mume Species 0.000 claims 1
- PANBYUAFMMOFOV-UHFFFAOYSA-N sodium;sulfuric acid Chemical compound [Na].OS(O)(=O)=O PANBYUAFMMOFOV-UHFFFAOYSA-N 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 208000002064 Dental Plaque Diseases 0.000 abstract description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 abstract description 7
- 210000000214 mouth Anatomy 0.000 abstract description 7
- 241000894006 Bacteria Species 0.000 abstract description 4
- 235000013373 food additive Nutrition 0.000 abstract description 4
- 239000002778 food additive Substances 0.000 abstract description 4
- 239000011780 sodium chloride Substances 0.000 abstract description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
- 229940069428 antacid Drugs 0.000 abstract 1
- 239000003159 antacid agent Substances 0.000 abstract 1
- 230000001458 anti-acid effect Effects 0.000 abstract 1
- 230000005548 health behavior Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 238000009835 boiling Methods 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 210000004489 deciduous teeth Anatomy 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 241000194023 Streptococcus sanguinis Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 210000003133 primary dentition Anatomy 0.000 description 2
- 230000005207 primary tooth eruption Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000252229 Carassius auratus Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 210000002455 dental arch Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000011841 epidemiological investigation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000001847 jaw Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000036445 liquid secretion Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 210000003707 mixed dentition Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 235000021058 soft food Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000021147 sweet food Nutrition 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of natural child's collutory, described natural child's collutory consists of the following composition: Chinese medicine extract 75.0% 89.0%, surfactant 1.5% 3.0%, coloring agent 1.0% 5.0%, flavouring agent 1.0% 8.0%, sweeting agent 1.5% 10.0%, preservative 0.3% 1.0%, sodium chloride 3.5% 6.0%.The present invention natural child collutory is mainly made up of Chinese medicine ingredients and food additive, non-stimulated to oral cavity, there is bacteriostasis and capacity antacid, Oral health behaviours can be maintained to balance, balance oral cavity acid-base value, it is possible to suppress, remove oral cavity bacterium, improve dental plaque, effectively prevent decayed tooth, keep breath freshening.
Description
[technical field]
The present invention relates to a kind of natural child's collutory.
[background technology]
After people's birth, 6-7 month deciduous teeth start eruption, 3-6 year complete primary dentition and grow, within i.e. 6 months-6 years old, be primary dentition rank
Section.6-12 year be the mixed dentition stage, exuviation, permanent teeth eruption successively, until all deciduous teeth is replaced complete.This single order
Section, existing deciduous teeth in oral cavity, also there is permanent teeth, be child's jawbone and dental arch primary growth period of development, be also the pass of permanent teeth jaw foundation
Key period.And show according to Third National oral health epidemiological investigation report result, 5 years old child's Primary Caries rate of China
It is 66.0%.Dental caries is bacterial disease, alveolar bone and jawbone even can be caused scorching with secondary pulpitis and periapicalitis
Disease etc..Tooth is susceptible to suffer from the main associated factors of dental caries to be had: child takes food the number of times of sweet food and the dynamics of oral cavity cleaning every day.Child is frequent
Taking food, and diet mostly is soft food, toughness is strong, and sugar content is high, constitutes antibacterial fertile soil, easily forms bacterial plaque, greatly
Amount antibacterial takes in the sugar in saliva, decomposes sugar and produces acid, and after feed, saliva acidity increases, and repeatedly feed makes saliva be in acid for a long time
Sexual state, more once feed equivalent food is easier to suffer from dental caries.The length of one's sleep of child is long, and oral cavity remains static, saliva
Liquid secretion is few, and self-cleaning action is poor, beneficially bacterial reproduction, increases and suffers from dental caries chance.
At present, dental caries is common in child, and the collutory for child is fewer, and most collutory all compares thorn
Swash, and containing ethanol, chemicals etc..And child is due to oneself swallow the most uncontrollable, therefore gargles in use
Gulped down during water the most by mistake, easily caused the injury to health.
[summary of the invention]
The present invention is directed to the deficiencies in the prior art, it is provided that a kind of natural child's collutory, described natural child collutory master
Wanting composition is Chinese herbal medicine and food additive, without harmful chemicals composition, can effectively treat dental caries, prevent the product of dental caries
Raw.
For reaching above-mentioned purpose, the present invention adopts the following technical scheme that a kind of natural child's collutory, described natural child
Collutory includes by weight percentage:
Wherein, described Chinese medicine extract is mainly prepared from the following materials: fancy carnation, youth-and-old-age, Callistephus chinensis, Carassius auratus
Grass, HONGQIAOMEI, Caulis Piperis Kadsurae, Herba Aristolochiae Mollissimae, Herb Pararuelliae delavayanae, all drench rattan, Herba Stephaniae Longae, Caulis Trachelospermi, Herba Catharanthi Rosei, logical Herba Euphorbiae Humifusae.
Further, described Chinese medicine extract is mainly prepared from by following raw material: fancy carnation 10-15 part,
Youth-and-old-age 8-12 part, Callistephus chinensis 6-10 part, Antirrhinum majus L. 6-10 part, HONGQIAOMEI 15-20 part, Caulis Piperis Kadsurae 15-20 part, Herba Aristolochiae Mollissimae 5-8 part,
Herb Pararuelliae delavayanae 6-12 part, all drench rattan 12-16 part, Herba Stephaniae Longae 12-16 part, Caulis Trachelospermi 8-12 part, Herba Catharanthi Rosei 5-10 part, logical Herba Euphorbiae Humifusae 5-10
Part.
Further, described Chinese medicine extract is mainly prepared from by following raw material: fancy carnation 12 parts, one hundred days
Grass 10 parts, Callistephus chinensis 8 parts, Antirrhinum majus L. 8 parts, HONGQIAOMEI 18 parts, Caulis Piperis Kadsurae 18 parts, Herba Aristolochiae Mollissimae 6 parts, Herb Pararuelliae delavayanae 9 parts, all drench rattan 14
Part, Herba Stephaniae Longae 14 parts, Caulis Trachelospermi 10 parts, Herba Catharanthi Rosei 8 parts, logical Herba Euphorbiae Humifusae 8 parts.
Further, described surfactant is sodium laurylsulfate, and sodium lauryl sulfate has good emulsifying, oozes
Thoroughly, decontamination and dispersive property, collutory adds appropriate sodium laurylsulfate, the zest of collutory can be reduced, with
Time improve again the stability of collutory.
Further, described coloring agent is natural mulberry juice, and its adhesive force and covering power are very big, are also that child generally likes
The color liked, and mulberry fruit is rich in sugar, organic acid, aminoacid, vitamin, micronutrient element, it is also possible to produce for tooth
Supplement required nutrition.
Further, described flavouring agent is that natural citrus is fragrant, and natural citrus is fragrant as flavouring agent, has salubrious, awake simultaneously
Brain, the effect refreshed oneself.
Further, described sweeting agent is natural fructose.
Further, described preservative is potassium sorbate, and potassium sorbate is food additive, has safety.
The preparation method step of the present invention is as follows:
1) take fancy carnation, youth-and-old-age, Callistephus chinensis, Antirrhinum majus L., HONGQIAOMEI, Caulis Piperis Kadsurae, Herba Aristolochiae Mollissimae, Herb Pararuelliae delavayanae, all drench rattan, excrement
Dustpan is sincere, Caulis Trachelospermi, Herba Catharanthi Rosei, logical Herba Euphorbiae Humifusae, clean, dry, put in terrine, add raw material gross weight 7-10 times in terrine
0.1% neutral sodium fluoride aqueous solution, soaks 20-26 hour, and intense fire decocts 1.5-2 hour, and slow fire boiling 2.5-4 hour takes and carries
Take liquid；Adding 0.1% neutral sodium fluoride aqueous solution of medicinal residues gross weight 6-8 times amount, intense fire decocts 0.5-1 hour, and slow fire is decocted
Boil 2-3 hour, take extracting solution；Adding 0.1% neutral sodium fluoride aqueous solution of medicinal residues gross weight 6-8 times, intense fire decocts 0.5-1
Hour, slow fire boiling 2-3 hour, take extracting solution；Mix three times and decoct gained extracting solution, obtain mixed extract, standby；
2) mixed extract of previous step gained is put into high speed centrifuge is centrifuged separate, centrifuging temperature is set as
5 DEG C, the time is 30min, and rotating speed is 7500rpm/min, takes supernatant after being centrifuged；
3) supernatant of previous step gained being carried out concentration, being concentrated into relative density is 3.5-4.0mg/ml；
4) finally in the concentrated solution of previous step gained, surfactant, coloring agent, flavouring agent, sweeting agent, anticorrosion are added
Agent, sodium chloride, under vacuo mixed at high speed 20-30 minute, can be prepared by.
The present invention has the beneficial effect that:
1, the present invention can quickly remove the spot being deeply hidden in teeth space, and gos deep into pharyngeal comprehensive cleaning；
2, the present invention can eliminate halitosis, effectively prevention, alleviation halitosis；
3, the present invention have pathogenic fire reducing, clean the teeth, teeth consolidating multiple efficacies, accomplish the total care to tooth；
4, the present invention is high to the killing rate of harmful bacteria, can safeguard that oral cavity flora balances, and improves dental plaque；
5, the present invention can stimulate and salivates, balances intraoral pH-value, reaches natural antibacterial effect；
6, the present invention can increase the calcareous of the flank of tooth and other nutritional labelings, and the nutrient needed for providing for tooth；
7, the present invention is mainly composed of Chinese herbal medicine and food additive, without harmful chemicals composition, has stronger
Safety；
8, the present invention is non-stimulated, oral mucosa will not be produced any toxic and side effects after entrance.
[detailed description of the invention]
The following examples can help those skilled in the art that the present invention is more fully understood, but cannot be with any
Mode limits the present invention.
Embodiment 1
A kind of natural child's collutory, component mark by weight is calculated as follows:
Described Chinese medicine extract is prepared from by the raw material of following weight portion: fancy carnation 15 parts, youth-and-old-age 10 parts, Callistephus chinensis
9 parts, Antirrhinum majus L. 6 parts, HONGQIAOMEI 18 parts, Caulis Piperis Kadsurae 15 parts, Herba Aristolochiae Mollissimae 8 parts, Herb Pararuelliae delavayanae 9 parts, all drench 13 parts of rattan, Herba Stephaniae Longae 15
Part, Caulis Trachelospermi 10 parts, Herba Catharanthi Rosei 10 parts, logical Herba Euphorbiae Humifusae 5 parts.
Embodiment 2
A kind of natural child's collutory, component mark by weight is calculated as follows:
Described Chinese medicine extract is prepared from by the raw material of following weight portion: fancy carnation 14 parts, youth-and-old-age 8 parts, Callistephus chinensis 7
Part, Antirrhinum majus L. 10 parts, HONGQIAOMEI 20 parts, Caulis Piperis Kadsurae 17 parts, Herba Aristolochiae Mollissimae 7 parts, Herb Pararuelliae delavayanae 6 parts, all drench 12 parts of rattan, Herba Stephaniae Longae 16
Part, Caulis Trachelospermi 11 parts, Herba Catharanthi Rosei 6 parts, logical Herba Euphorbiae Humifusae 10 parts.
Embodiment 3
A kind of natural child's collutory, component mark by weight is calculated as follows:
Described Chinese medicine extract is prepared from by the raw material of following weight portion: fancy carnation 12 parts, youth-and-old-age 10 parts, Callistephus chinensis
8 parts, Antirrhinum majus L. 8 parts, HONGQIAOMEI 18 parts, Caulis Piperis Kadsurae 18 parts, Herba Aristolochiae Mollissimae 6 parts, Herb Pararuelliae delavayanae 9 parts, all drench 14 parts of rattan, Herba Stephaniae Longae 14
Part, Caulis Trachelospermi 10 parts, Herba Catharanthi Rosei 8 parts, logical Herba Euphorbiae Humifusae 8 parts.
Embodiment 4
A kind of natural child's collutory, component mark by weight is calculated as follows:
Described Chinese medicine extract is prepared from by the raw material of following weight portion: fancy carnation 10 parts, youth-and-old-age 11 parts, Callistephus chinensis
6 parts, Antirrhinum majus L. 9 parts, HONGQIAOMEI 15 parts, Caulis Piperis Kadsurae 16 parts, Herba Aristolochiae Mollissimae 5 parts, Herb Pararuelliae delavayanae 12 parts, all drench 15 parts of rattan, Herba Stephaniae Longae 12
Part, Caulis Trachelospermi 8 parts, Herba Catharanthi Rosei 5 parts, logical Herba Euphorbiae Humifusae 6.
Part embodiment 5
A kind of natural child's collutory, component mark by weight is calculated as follows:
Described Chinese medicine extract is prepared from by the raw material of following weight portion: fancy carnation 13 parts, youth-and-old-age 12 parts, Callistephus chinensis
10 parts, Antirrhinum majus L. 7 parts, HONGQIAOMEI 16 parts, Caulis Piperis Kadsurae 20 parts, Herba Aristolochiae Mollissimae 7 parts, Herb Pararuelliae delavayanae 6 parts, all drench 16 parts of rattan, Herba Stephaniae Longae 13
Part, Caulis Trachelospermi 12 parts, Herba Catharanthi Rosei 9 parts, logical Herba Euphorbiae Humifusae 7 parts.
The preparation method of natural child's collutory described in embodiment of the present invention 1-5:
1) take fancy carnation, youth-and-old-age, Callistephus chinensis, Antirrhinum majus L., HONGQIAOMEI, Caulis Piperis Kadsurae, Herba Aristolochiae Mollissimae, Herb Pararuelliae delavayanae, all drench rattan, excrement
Dustpan is sincere, Caulis Trachelospermi, Herba Catharanthi Rosei, logical Herba Euphorbiae Humifusae, clean, dry, put in terrine, add raw material gross weight 7-10 times in terrine
0.1% neutral sodium fluoride aqueous solution, soaks 20-26 hour, and intense fire decocts 1.5-2 hour, and slow fire boiling 2.5-4 hour takes and carries
Take liquid；Adding 0.1% neutral sodium fluoride aqueous solution of medicinal residues gross weight 6-8 times amount, intense fire decocts 0.5-1 hour, and slow fire is decocted
Boil 2-3 hour, take extracting solution；Adding 0.1% neutral sodium fluoride aqueous solution of medicinal residues gross weight 6-8 times, intense fire decocts 0.5-1
Hour, slow fire boiling 2-3 hour, take extracting solution；Mix three times and decoct gained extracting solution, obtain mixed extract, standby；
2) mixed extract of previous step gained is put into high speed centrifuge is centrifuged separate, centrifuging temperature is set as
5 DEG C, the time is 30min, and rotating speed is 7500rpm/min, takes supernatant after being centrifuged；
3) supernatant of previous step gained being carried out concentration, being concentrated into relative density is 3.5-4.0mg/ml；
4) finally in the concentrated solution of previous step gained, surfactant, coloring agent, flavouring agent, sweeting agent, anticorrosion are added
Agent, sodium chloride, under vacuo mixed at high speed 20-30 minute, can be prepared by.
Draw through repetition test: the present invention is a child's collutory efficiently, having no side effect.
Test one: bacteriostatic experiment
Use filter paper enzyme measure made toothpaste bacteriostasis, the strain of selection is: Streptococcus mutans, Streptococcus sanguis,
Escherichia coli, Candida albicans；Concrete grammar is as follows: is mixed with normal saline by the strain cultivating 24h under the conditions of 35 DEG C, makes to mix
Close liquid bacterial content and reach 105cfu/ml；Take 0.1ml bacterium solution to be uniformly coated on solid medium, take 10ul embodiment 1-5 not
Soak the aseptic filter paper sheet of a diameter of 6mm with the collutory of formula, sterilized water, filter paper is placed on painting bacterium culture medium, is placed in
Cultivate 24h under the conditions of 35 DEG C, observe antibacterial circle diameter, the bacteriostasis of preliminary judgement sample.
Table 1: the antibacterial circle diameter (mm) that different formulations produces
Conclusion: the present invention has stronger inhibitory action to Streptococcus mutans, Streptococcus sanguis, escherichia coli, Candida albicans,
Good stability, bactericidal effect are good.
Experiment two: toxicity test
Mice is divided three groups gavage natural child's collutory that various dose is prepared by the present invention respectively, observes mice reaction
Situation, draws following result:
Table 2: toxicity test result
| Dosage | Size of animal | Death toll | Mortality rate (%) |
| 1000ml/kg | 20 | 0 | 0 |
| 2000ml/kg | 20 | 0 | 0 |
| 2500ml/kg | 20 | 0 | 0 |
Conclusion shows: the present invention natural child collutory is nontoxic, non-stimulated.
Choose 5 4-7 year suffer from dental caries child volunteer, serial number 1-5, before experiment, they have been carried out the average pH of dental plaque fluid
The mensuration of value.Test result is as follows:
Table 3: pH of dental plaque fluid measurement result before experiment
Then, experimenter uses the collutory of present invention modulation to gargle by regulation requirement, 3-5 time on the one.Test 2 weeks
After, redeterminate the mean ph value of dental plaque fluid, test result such as table 4:
Table 4: pH of dental plaque fluid measurement result after test
| Sequence number | Age | PH value | F value |
| 1 | 5 | 6.27±0.38 | 0.041 |
| 2 | 7 | 6.45±0.32 | 0.036 |
| 3 | 6 | 6.39±0.31 | 0.037 |
| 4 | 7 | 6.44±0.30 | 0.039 |
| 5 | 4 | 6.40±0.29 | 0.040 |
Before and after experiment, contrast shows: after using the present invention natural child collutory, the pH value of dental plaque fluid is significantly raised, permissible
Effectively treat, prevent dental caries.
Described above is the detailed description for the preferable possible embodiments of the present invention, but embodiment is not limited to this
Bright patent claim, the equal change completed under the technical spirit suggested by all present invention or modification change, all should belong to
In the contained the scope of the claims of the present invention.
Claims (8)
1. natural child's collutory, it is characterised in that described natural child's collutory includes by weight percentage:
Wherein, described Chinese medicine extract is mainly prepared from the following materials: fancy carnation, youth-and-old-age, Callistephus chinensis, Antirrhinum majus L., red
Skilful prunus mume (sieb.) sieb.et zucc., Caulis Piperis Kadsurae, Herba Aristolochiae Mollissimae, Herb Pararuelliae delavayanae, all drench rattan, Herba Stephaniae Longae, Caulis Trachelospermi, Herba Catharanthi Rosei, logical Herba Euphorbiae Humifusae.
Natural child's collutory the most according to claim 1, it is characterised in that described Chinese medicine extract is mainly by weighing as follows
Amount part raw material is prepared from: fancy carnation 10-15 part, youth-and-old-age 8-12 part, Callistephus chinensis 6-10 part, Antirrhinum majus L. 6-10 part, HONGQIAOMEI
15-20 part, Caulis Piperis Kadsurae 15-20 part, Herba Aristolochiae Mollissimae 5-8 part, Herb Pararuelliae delavayanae 6-12 part, all drench rattan 12-16 part, Herba Stephaniae Longae 12-16 part, network
Stone rattan 8-12 part, Herba Catharanthi Rosei 5-10 part, logical Herba Euphorbiae Humifusae 5-10 part.
Natural child's collutory the most according to claim 2, it is characterised in that described Chinese medicine extract is mainly by weighing as follows
Amount part raw material is prepared from: fancy carnation 12 parts, youth-and-old-age 10 parts, Callistephus chinensis 8 parts, Antirrhinum majus L. 8 parts, HONGQIAOMEI 18 parts, Caulis Piperis Kadsurae
18 parts, Herba Aristolochiae Mollissimae 6 parts, Herb Pararuelliae delavayanae 9 parts, all drench 14 parts of rattan, Herba Stephaniae Longae 14 parts, Caulis Trachelospermi 10 parts, Herba Catharanthi Rosei 8 parts, logical Herba Euphorbiae Humifusae 8
Part.
Natural child's collutory the most according to claim 1, it is characterised in that: described surfactant is lauryl alcohol sulphuric acid
Sodium.
Natural child's collutory the most according to claim 1, it is characterised in that: described coloring agent is natural mulberry juice.
Natural child's collutory the most according to claim 1, it is characterised in that: described flavouring agent is that natural citrus is fragrant.
Natural child's collutory the most according to claim 1, it is characterised in that: described sweeting agent is natural fructose.
Natural child's collutory the most according to claim 1, it is characterised in that: described preservative is potassium sorbate.
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| CN201610737399.0A CN106236645A (en) | 2016-08-26 | 2016-08-26 | A kind of natural child's collutory |
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| CN201610737399.0A CN106236645A (en) | 2016-08-26 | 2016-08-26 | A kind of natural child's collutory |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233264A (en) * | 2017-08-09 | 2017-10-10 | 何家平 | A kind of high pressure distillation Chinese herbal medicine toothwash hydraulic art |
| CN109589287A (en) * | 2019-02-02 | 2019-04-09 | 江西普正制药有限公司 | A kind of callicarpa nudiflora toothpaste and preparation method thereof |
-
2016
- 2016-08-26 CN CN201610737399.0A patent/CN106236645A/en active Pending
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233264A (en) * | 2017-08-09 | 2017-10-10 | 何家平 | A kind of high pressure distillation Chinese herbal medicine toothwash hydraulic art |
| CN109589287A (en) * | 2019-02-02 | 2019-04-09 | 江西普正制药有限公司 | A kind of callicarpa nudiflora toothpaste and preparation method thereof |
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