CN106176324B - A kind of Whitening sunscreen cream and preparation method thereof containing Noni fruit essential oil - Google Patents
A kind of Whitening sunscreen cream and preparation method thereof containing Noni fruit essential oil Download PDFInfo
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- CN106176324B CN106176324B CN201610783591.3A CN201610783591A CN106176324B CN 106176324 B CN106176324 B CN 106176324B CN 201610783591 A CN201610783591 A CN 201610783591A CN 106176324 B CN106176324 B CN 106176324B
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- essential oil
- noni fruit
- fruit essential
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- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 115
- 235000017524 noni Nutrition 0.000 title claims abstract description 110
- 244000131360 Morinda citrifolia Species 0.000 title claims abstract description 109
- 239000000341 volatile oil Substances 0.000 title claims abstract description 108
- 230000002087 whitening effect Effects 0.000 title claims abstract description 57
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 52
- 239000006071 cream Substances 0.000 title claims abstract description 50
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 38
- 239000002994 raw material Substances 0.000 claims abstract description 49
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 42
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 40
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- -1 sterol ester Chemical class 0.000 claims abstract description 27
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 21
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 21
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 21
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 21
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 21
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 21
- 229940046009 vitamin E Drugs 0.000 claims abstract description 21
- 239000011709 vitamin E Substances 0.000 claims abstract description 21
- 229940119170 jojoba wax Drugs 0.000 claims abstract description 20
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 20
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims abstract description 20
- 229960002216 methylparaben Drugs 0.000 claims abstract description 20
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 19
- 229930182558 Sterol Natural products 0.000 claims abstract description 19
- 229960000458 allantoin Drugs 0.000 claims abstract description 19
- 235000003702 sterols Nutrition 0.000 claims abstract description 19
- 150000001413 amino acids Chemical class 0.000 claims abstract description 18
- 239000003906 humectant Substances 0.000 claims abstract description 16
- 229940024606 amino acid Drugs 0.000 claims abstract description 3
- 235000001014 amino acid Nutrition 0.000 claims abstract description 3
- 238000003756 stirring Methods 0.000 claims description 45
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- 238000002156 mixing Methods 0.000 claims description 21
- 239000006210 lotion Substances 0.000 claims description 16
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 13
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 12
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 12
- 150000002191 fatty alcohols Chemical class 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 10
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 9
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 9
- 230000002045 lasting effect Effects 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000004909 Moisturizer Substances 0.000 claims description 4
- 230000001333 moisturizer Effects 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims 2
- 241000259759 Cassida nobilis Species 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000010025 steaming Methods 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 28
- 102000003425 Tyrosinase Human genes 0.000 abstract description 19
- 108060008724 Tyrosinase Proteins 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 16
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 abstract description 11
- 238000010521 absorption reaction Methods 0.000 abstract description 9
- 230000005855 radiation Effects 0.000 abstract description 8
- 239000002537 cosmetic Substances 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 206010040829 Skin discolouration Diseases 0.000 abstract description 4
- 230000007760 free radical scavenging Effects 0.000 abstract description 4
- 230000037072 sun protection Effects 0.000 abstract description 3
- 238000004821 distillation Methods 0.000 description 14
- 239000000523 sample Substances 0.000 description 12
- 238000002835 absorbance Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 241000252212 Danio rerio Species 0.000 description 7
- 206010013786 Dry skin Diseases 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 239000000049 pigment Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 210000001161 mammalian embryo Anatomy 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000031700 light absorption Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- XZOYHFBNQHPJRQ-UHFFFAOYSA-N 7-methyloctanoic acid Chemical compound CC(C)CCCCCC(O)=O XZOYHFBNQHPJRQ-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- DIBAKBGYJUCGDL-UHFFFAOYSA-N 2,6-diamino-n-[1-[(2-amino-2-oxoethyl)amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCCC(N)C(=O)NC(C(=O)NCC(N)=O)CC1=CN=CN1 DIBAKBGYJUCGDL-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000157491 Morinda Species 0.000 description 2
- 230000002292 Radical scavenging effect Effects 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 108010026970 bursopoietin Proteins 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical group CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- VAJVDSVGBWFCLW-UHFFFAOYSA-N 3-Phenyl-1-propanol Chemical compound OCCCC1=CC=CC=C1 VAJVDSVGBWFCLW-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 102000030523 Catechol oxidase Human genes 0.000 description 1
- 108010031396 Catechol oxidase Proteins 0.000 description 1
- 241000448255 Congiopodus peruvianus Species 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- DYUQAZSOFZSPHD-UHFFFAOYSA-N Phenylpropyl alcohol Natural products CCC(O)C1=CC=CC=C1 DYUQAZSOFZSPHD-UHFFFAOYSA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
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- 239000000975 dye Substances 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 125000001474 phenylpropanoid group Chemical group 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of Whitening sunscreen creams containing Noni fruit essential oil, including following raw material components: Noni fruit essential oil, jojoba oil, sterol ester, vitamin E, methylparaben, ethylparaben, amino acid humectant, allantoin, deionized water；Wherein, jojoba oil, sterol ester, vitamin E, methylparaben, the raw material that ethylparaben is A phase；Amino acid humectant, allantoin, the raw material that deionized water is B phase；Noni fruit essential oil is the raw material of D phase.A kind of Whitening sunscreen cream containing Noni fruit essential oil of the invention, with significant DPPH free radical scavenging ability, effectively inhibit the activity of tyrosinase, inhibit melanin growth, it is good to ultraviolet radiation absorption effect, realize the effect of whitening sun protection skin care, preparation method is simple to operation, lower production costs.In addition, Noni fruit essential oil proposed by the present invention may be directly applied to skin care whitening, also can be applied to prepare other skin-lightening cosmetics or skin care item product.
Description
Technical field
The present invention relates to Noni fruits to be applied to cosmetic field more particularly to a kind of whitening sun protection containing Noni fruit essential oil
Frost and preparation method thereof.
Background technique
Nuo Li is Rubiaceae Morinda plant also known as Morinda, and four seasons fruit, India's mulberries, the plant is usually coastwise
It is grown in the bushes at seabeach and the seashore of more stones, roadside, streams takes up wetland, be mainly distributed on the South Sea Islands
Small island, such as Philippine, Australia, Cambodia.Also there are a large amount of plantation, conservative estimation cultivated area in existing China Hainan, Taiwan
10000 mu of Hainan, 4000 mu of Yunnan.Nuo Li contains 60 multiple nutritional components, including vitamin, microelement, flavones, phenylpropyl alcohol
Element, polysaccharide etc. have stronger functional characteristic, and root, stem, leaf, flower, fruit can be used as medicine.Root can get the dyestuff of yellow or red
For contaminating clothes, edible fruit is used, as food and health care product.The Polynesian on South Pacific Ocean island is beautiful as food by promise
There are about history in 2000 for product, drug.Nuo Li can inhibit and cure a variety of diseases.Such as arthritis, diabetes, hypertension, muscle
Pain, irregular menstruation, headache, heart disease, AIDS, tumour, digestive tract ulcer, various strains, depression, aging, indigestion,
Artery sclerosis problem and is addicted to drug in terms of blood vessel.Phenylpropanoids can inhibit tyrosinase according to the literature
Activity, tyrosinase are also known as polyphenol oxidase, are widely present in plant, animal and microbial body, are the limits of B16 cell
Fast enzyme controls the production quantity of the i.e. controllable melanin of its vigor.It has been that the whole world is most in great demand due to the beautiful unique functional characteristic of promise
One of health-oriented products, the existing market demand beautiful to promise increase with annual 50% speed, government also increase it is beautiful to promise
Exploitation and development.But application of the current Noni fruit essential oil on skin-lightening cosmetic or skin care item is badly in need of out also in blank stage
Hair application.
Summary of the invention
In view of this, the present invention provides a kind of Whitening sunscreen cream and preparation method thereof containing Noni fruit essential oil.
The technological means that the present invention uses is as follows: a kind of Whitening sunscreen cream containing Noni fruit essential oil, including following raw material
Component: Noni fruit essential oil, jojoba oil, sterol ester, vitamin E, methylparaben, ethylparaben, amino acid humectant, urine
Bursin, deionized water；
Wherein, jojoba oil, sterol ester, vitamin E, methylparaben, the raw material that ethylparaben is A phase；Amino acid
Moisturizer, allantoin, the raw material that deionized water is B phase；Noni fruit essential oil is the raw material of D phase.
Preferably, the raw material further include lauryl alcohol, tristerin, 16/18 natural fatty alcohols, octanoic acid/
Triglyceride DDD, isononyl isononanoate, dimethyl silicone polymer, glycerol；
Wherein, tristerin, 16/18 natural fatty alcohols, caprylic/capric triglyceride, isononyl isononanoate,
Jojoba oil, dimethyl silicone polymer, sterol ester, vitamin E, methylparaben, the raw material that ethylparaben is A phase；Glycerol,
Amino acid humectant, allantoin, the raw material that deionized water is B phase；Lauryl alcohol is the raw material of C phase；Noni fruit essential oil is D phase
Raw material.
Preferably, the weight part ratio of the raw material are as follows: 0.8~1.2 part of Noni fruit essential oil, 1~1.2 part of jojoba oil, steroid
0.8~1 part of alcohol ester, 0.5~1 part of vitamin E, 0.1~0.3 part of methylparaben, 0.05~0.15 part of ethylparaben, ammonia
2~3 parts of base acid moisturizer, 0.2~0.4 part of allantoin, 90~110 parts of deionized water.
Preferably, the weight part ratio of the raw material are as follows: 0.8~1.2 part of Noni fruit essential oil, 1~1.2 part of jojoba oil, steroid
0.8~1 part of alcohol ester, 0.5~1 part of vitamin E, 0.1~0.3 part of methylparaben, 0.05~0.15 part of ethylparaben, ammonia
2~3 parts of base acid moisturizer, 0.2~0.4 part of allantoin, 90~110 parts of deionized water, 0.7~0.9 part of lauryl alcohol, stearic acid
1~1.5 part of glyceride, 0.4~0.6 part of 16/18 natural fatty alcohol, 2~3 parts of caprylic/capric triglyceride, isononanoic acid are different
3~5 parts of nonyl ester, 0.5~1 part of dimethyl silicone polymer, 3~5 parts of glycerol.
Preferably, the weight part ratio of the raw material are as follows: 1 part of Noni fruit essential oil, 1~1.2 part of jojoba oil, sterol ester 0.8
~1 part, 0.5~1 part of vitamin E, 0.2 part of methylparaben, 0.1 part of ethylparaben, 2~3 parts of amino acid humectant, urine
0.3 part of Bursin, 100 parts of deionized water, 0.8 part of lauryl alcohol, 1~1.5 part of tristerin, 16/18 natural fats
It is 0.5 part of alcohol, 2~3 parts of caprylic/capric triglyceride, 3~5 parts of isononyl isononanoate, 0.5~1 part of dimethyl silicone polymer, sweet
3~5 parts of oil.
Preferably, the preparation method of the Noni fruit essential oil is the following steps are included: by the fresh Noni fruit of chopping and distillation
Water mixing, is put into distiller, connects aspiration pump, is evaporated under reduced pressure 2~4h, and the volatile oil of acquisition is Noni fruit essential oil.
Preferably, the preparation method of the Noni fruit essential oil is the following steps are included: by the fresh Noni fruit of chopping and distillation
Water mixing, is put into distiller, and gained phegma is stood, extracts phegma supernatant liquid, i.e., by air-distillation 2~4h of reflux
Obtain Noni fruit essential oil.
Preferably, the volume of the distilled water is that 150ml distilled water is added in each hectogram Noni fruit.
The present invention also provides a kind of preparation methods of Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) prepare the raw material of A phase, B phase, D phase；
(2) A phase, B phase are deployed: preparing A phase, B phase respectively, and difference heating stirring is in homogeneous to 80~90 DEG C；
(3) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under 800~1200 rev/min states of stirring until two by the two-phase temperature difference≤5 DEG C
It is mutually thoroughly mixed, starts homogenizer, make emulsion-stabilizing and glossy；When temperature is down to 40~50 DEG C, D phase is added, persistently stirs
It mixes, lotion is down to room temperature, stops stirring, stands 18~24 hours, and the Whitening sunscreen cream containing Noni fruit essential oil is made.
The present invention also provides a kind of preparation methods of Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) prepare the raw material of A phase, B phase, C phase, D phase；
(2) A phase, B phase are deployed: preparing A phase, B phase respectively, and difference heating stirring is in homogeneous to 80~90 DEG C；
(3) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under 800~1200 rev/min states of stirring until two by the two-phase temperature difference≤5 DEG C
It is mutually thoroughly mixed, starts homogenizer, make emulsion-stabilizing and glossy；When temperature is 60~70 DEG C, C phase is added, starts again
Homogenizer, until lotion is uniformly mixed；When temperature is down to 40~50 DEG C, D phase is added, lasting to stir, lotion is down to room temperature, is stopped
It only stirs, stands 18~24 hours, the Whitening sunscreen cream containing Noni fruit essential oil is made.
The utility model has the advantages that a kind of Whitening sunscreen cream containing Noni fruit essential oil of the invention, has significant DPPH free radical
Scavenging activity effectively inhibits the activity of tyrosinase, inhibits melanin growth, good to ultraviolet radiation absorption effect, realizes that whitening is anti-
Shine the effect of skin care.And the preparation method of Whitening sunscreen cream of the present invention is simple to operation, lower production costs, wherein benefit
Noni fruit essential oil is made with distillation under vacuum and atmospheric distillation, it is best in quality, there is preferable DPPH radical scavenging activity
Power, may be directly applied to skin care whitening, also can be applied to prepare other skin-lightening cosmetics or skin care item product.
Detailed description of the invention
Fig. 1 is sample liquid to zebrafish embryo pigment growth inhibition situation, A: normal zebrafish embryo, B: 6 sample of embodiment
Influence of the product liquid to pigment.
Specific embodiment
The principles and features of the present invention are described below, and illustrated embodiment is served only for explaining the present invention, is not intended to
It limits the scope of the invention.
Embodiment 1
A kind of Whitening sunscreen cream containing Noni fruit essential oil, including following raw material components:
A phase: 1 part of jojoba oil, 0.8 part of sterol ester, 0.5 part of vitamin E, 0.1 part of methylparaben, ethylparaben
0.05 part；
B phase: 2 parts of amino acid humectant, 0.2 part of allantoin, 90 parts of deionized water；
D phase: 0.8 part of Noni fruit essential oil.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) Noni fruit essential oil prepares (distillation under vacuum): it takes the fresh Noni fruit of 200g to shred, mixes 300mL distilled water,
It is placed in clean 500mL cucurbit, with aspiration pump by heating mantle heats to boiling, vacuum distillation 2h extracts volatile oil, i.e.,
Noni fruit essential oil is obtained, is the raw material of D phase；
(2) prepare the raw material of A phase, B phase；
(3) A phase, B phase: the 150ml beaker after taking two sterilizing-dryings are deployed, prepares A phase, B phase respectively, and heat respectively
Stirring is to 80~90 DEG C in homogeneous；
(4) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under the 800 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 40 DEG C, D phase is added, lasting to stir, lotion is down to
Room temperature closes blender, stops stirring, bottles after standing 18 hours, and the Whitening sunscreen cream containing Noni fruit essential oil is made.
Embodiment 2
A kind of Whitening sunscreen cream containing Noni fruit essential oil, including following raw material components:
A phase: 1.2 parts of jojoba oil, 1 part of sterol ester, 1 part of vitamin E, 0.3 part of methylparaben, ethylparaben
0.15 part；
B phase: 3 parts of amino acid humectant, 0.4 part of allantoin, 110 parts of deionized water；
D phase: 1.2 parts of Noni fruit essential oil.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) Noni fruit essential oil prepares (atmospheric distillation): it takes the fresh Noni fruit of 300g to shred, mixes 500mL distilled water,
It is placed in clean 1L cucurbit, is heated to boiling by electric jacket, air-distillation reflux 4h, gained phegma, which is stood, to be extracted
Layer liquid obtains essential oil, i.e. acquisition Noni fruit essential oil, is the raw material of D phase；
(2) prepare the raw material of A phase, B phase；
(3) A phase, B phase: the 150ml beaker after taking two sterilizing-dryings are deployed, prepares A phase, B phase respectively, and heat respectively
Stirring is to 80~90 DEG C in homogeneous；
(4) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under the 1200 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 50 DEG C, D phase is added, lasting to stir, lotion drop
To room temperature, blender is closed, stops stirring, is bottled after standing 24 hours, the Whitening sunscreen cream containing Noni fruit essential oil is made.
Embodiment 3
A kind of Whitening sunscreen cream containing Noni fruit essential oil, including following raw material components:
A phase: 1.2 parts of jojoba oil, 1 part of sterol ester, 1 part of vitamin E, 0.2 part of methylparaben, ethylparaben 0.1
Part；
B phase: 3 parts of amino acid humectant, 0.3 part of allantoin, 100 parts of deionized water；
D phase: 1.0 parts of Noni fruit essential oil.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) prepared by Noni fruit essential oil: using the preparation method of Noni fruit essential oil in embodiment 1, obtaining the raw material of D phase；
(2) prepare the raw material of A phase, B phase；
(3) A phase, B phase: the 150ml beaker after taking two sterilizing-dryings are deployed, prepares A phase, B phase respectively, and heat respectively
Stirring is to 80~90 DEG C in homogeneous；
(4) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under the 1000 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 45 DEG C, D phase is added, lasting to stir, lotion drop
To room temperature, blender is closed, stops stirring, is bottled after standing 24 hours, the Whitening sunscreen cream containing Noni fruit essential oil is made.
Embodiment 4
A kind of Whitening sunscreen cream containing Noni fruit essential oil, including following raw material components:
A phase: 1 part of jojoba oil, 0.8 part of sterol ester, 0.5 part of vitamin E, 0.1 part of methylparaben, ethylparaben
0.05 part, 1 part of tristerin, 0.4 part of 16/18 natural fatty alcohol, 2 parts of caprylic/capric triglyceride, isononanoic acid it is different
3 parts of nonyl ester, 0.5 part of dimethyl silicone polymer；
B phase: 2 parts of amino acid humectant, 0.2 part of allantoin, 90 parts of deionized water, 3 parts of glycerol；
C phase: 0.7 part of lauryl alcohol；
D phase: 0.8 part of Noni fruit essential oil.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) prepared by Noni fruit essential oil: using the preparation method of Noni fruit essential oil in embodiment 2, obtaining the raw material of D phase；
(2) prepare the raw material of A phase, B phase, C phase；
(3) A phase, B phase: the 150ml beaker after taking two sterilizing-dryings are deployed, prepares A phase, B phase respectively, and heat respectively
Stirring is to 80~90 DEG C in homogeneous；
(4) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under the 800 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60~70 DEG C, C phase is added, starts homogenizer again,
Until lotion is uniformly mixed；When temperature is down to 40 DEG C, D phase is added, lasting to stir, lotion is down to room temperature, closes blender, stops
It only stirs, bottles after standing 18 hours, the Whitening sunscreen cream containing Noni fruit essential oil is made.
Embodiment 5
A kind of Whitening sunscreen cream containing Noni fruit essential oil, including following raw material components:
A phase: 1.2 parts of jojoba oil, 1 part of sterol ester, 1 part of vitamin E, 0.3 part of methylparaben, ethylparaben
0.15 part, 1.5 parts of tristerin, 0.6 part of 16/18 natural fatty alcohol, 3 parts of caprylic/capric triglyceride, isononanoic acid
5 parts of different nonyl ester, 1 part of dimethyl silicone polymer；
B phase: 3 parts of amino acid humectant, 0.4 part of allantoin, 110 parts of deionized water, 5 parts of glycerol；
C phase: 0.9 part of lauryl alcohol；
D phase: 1.2 parts of Noni fruit essential oil.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) prepared by Noni fruit essential oil: using the preparation method of Noni fruit essential oil in embodiment 1, obtaining the raw material of D phase；
(2) prepare the raw material of A phase, B phase, C phase；
(3) A phase, B phase: the 150ml beaker after taking two sterilizing-dryings are deployed, prepares A phase, B phase respectively, and heat respectively
Stirring is to 80~90 DEG C in homogeneous；
(4) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under the 1200 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60~70 DEG C, C phase is added, starts homogeneous again
Machine, until lotion is uniformly mixed；When temperature is down to 50 DEG C, D phase is added, lasting to stir, lotion is down to room temperature, closes stirring
Device stops stirring, bottles after standing 24 hours, and the Whitening sunscreen cream containing Noni fruit essential oil is made.
Embodiment 6
A kind of Whitening sunscreen cream containing Noni fruit essential oil, including following raw material components:
A phase: 1 part of jojoba oil, 1 part of sterol ester, 1 part of vitamin E, 0.2 part of methylparaben, ethylparaben 0.1
Part, 1 part of tristerin, 0.5 part of 16/18 natural fatty alcohol, 2 parts of caprylic/capric triglyceride, isononyl isononanoate
3 parts, 1 part of dimethyl silicone polymer；
B phase: 2 parts of amino acid humectant, 0.3 part of allantoin, 100 parts of deionized water, 4 parts of glycerol；
C phase: 0.8 part of lauryl alcohol；
D phase: 1 part of Noni fruit essential oil.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit essential oil, comprising the following steps:
(1) prepared by Noni fruit essential oil: using the preparation method of Noni fruit essential oil in embodiment 2, obtaining the raw material of D phase；
(2) prepare A phase, B phase, C phase；
(3) A phase, B phase: the 150ml beaker after taking two sterilizing-dryings are deployed, prepares A phase, B phase respectively, and heat respectively
Stirring is to 80~90 DEG C in homogeneous；
(4) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and control the temperature range of A phase and B phase 80~
Between 90 DEG C, A phase is slowly added in B phase, under the 1000 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60~70 DEG C, C phase is added, starts homogeneous again
Machine, until lotion is uniformly mixed；When temperature is down to 45 DEG C, D phase is added, lasting to stir, lotion is down to room temperature, closes stirring
Device stops stirring, bottles after standing 24 hours, and the Whitening sunscreen cream containing Noni fruit essential oil is made.
Comparative example 1
A kind of frost without Noni fruit essential oil, including following raw material components:
A phase: 1 part of jojoba oil, 1 part of sterol ester, 1 part of vitamin E, 0.2 part of methylparaben, ethylparaben 0.1
Part, 1 part of tristerin, 0.5 part of 16/18 natural fatty alcohol, 2 parts of caprylic/capric triglyceride, isononyl isononanoate
3 parts, 1 part of dimethyl silicone polymer；
B phase: 2 parts of amino acid humectant, 0.3 part of allantoin, 100 parts of deionized water, 4 parts of glycerol；
C phase: 0.8 part of lauryl alcohol.
Preparation method: allotment A phase, B phase: the 150ml beaker after taking two sterilizing-dryings prepares A phase, B phase respectively, and
Heating stirring is to 80~90 DEG C in homogeneous respectively；Mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and controls A phase and B
The temperature range of phase is between 80~90 DEG C, the two-phase temperature difference≤5 DEG C, under the 1000 rev/min states of stirring, A phase is slow
It is added in B phase, until two-phase is thoroughly mixed, starts homogenizer, make emulsion-stabilizing and glossy；When temperature is 60~70 DEG C, add
Enter C phase, start homogenizer again, until lotion is uniformly mixed, lotion is down to room temperature, closes blender, stops stirring, stands 24
It bottles after hour, the frost without Noni fruit essential oil is made.
One, the antioxidant activity test of Noni fruit essential oil
1. the measurement of scavenging ability of DPPH free radical
A certain amount of DPPH is weighed, the DPPH solution of 0.04mg/mL is configured to dehydrated alcohol.Take 2mL difference dense respectively
2mL DPPH solution is added in the solution of essential oil made from the Examples 1 to 2 of degree (2,4,6,8mg/mL), is uniformly mixed, room temperature is put
After setting 30min, 5000r/min is centrifuged 10min.Supernatant is taken to survey light absorption value at 517nm.Use Vc as positive control.Sample
The clearance rate of DPPH free radical is calculated with following formula:
A0: the light absorption value of 2mL dehydrated alcohol+2mL DPPH solution；
A1: the light absorption value of 2mL sample solution+2mL DPPH solution；
A2: the light absorption value of 2mL sample solution+2mL dehydrated alcohol；
The test result that the DPPH clearance rate of Noni fruit essential oil is made in two methods is as shown in table 1:
| Embodiment | Embodiment 1 (distillation under vacuum) | Embodiment 2 (atmospheric distillation) |
| DPPH clearance rate (%) | 89.76 | 90.93 |
By table 1 the result shows that, distillation under vacuum of the invention and atmospheric distillation preparation essential oil all have preferably
DPPH free radical scavenging ability.
Two, ultraviolet light experiment is absorbed
The Whitening sunscreen cream containing Noni fruit essential oil and comparative example 1 of precise 0.06g Examples 1 to 6 respectively
Frost without Noni fruit essential oil is uniformly applied on the glass slide with medical adhesive tape, not smear the glass slide of suncream as sky
It is white, after timebase, the UV absorption average value of sample and reference substance in UVA, UVB, UVC wave band is scanned, it is more of the invention
The Whitening sunscreen cream containing Noni fruit essential oil and comparative example 1, blank control to ultraviolet radiation absorption situation.
Each embodiment and comparative example 1, blank control are shown in Table 2 to ultraviolet radiation absorption experimental result:
| Title | UVA (320~420nm) | UVB (275~320nm) | UVC (200~275nm) |
| Embodiment 1 | 2.1628 | 2.4583 | 2.4368 |
| Embodiment 2 | 2.2308 | 2.5613 | 2.5482 |
| Embodiment 3 | 2.4981 | 2.7419 | 2.7602 |
| Embodiment 4 | 2.2849 | 2.5537 | 2.5481 |
| Embodiment 5 | 2.3164 | 2.6105 | 2.6138 |
| Embodiment 6 | 2.5497 | 2.8988 | 2.8825 |
| Comparative example 1 | 0.8731 | 0.9528 | 0.9951 |
| Blank control product (0g) | 0.000 | 0.000 | 0.000 |
By table 2 the result shows that, Examples 1 to 6 be made the Whitening sunscreen cream containing Noni fruit essential oil to ultraviolet light inhale
Fruit of producing effects is good, has preferable sun-proof function.Wherein, embodiment 6 and embodiment 3 are preferable to ultraviolet radiation absorption effect, illustrate promise
When beautiful fruit essential oil weight part ratio is 1 part, Whitening sunscreen cream is best to ultraviolet radiation absorption effect.And comparative example 1 does not contain Noni fruit
The frost of essential oil is poor to ultraviolet radiation absorption.
Three, tyrosinase inhibitory activity measures
Tyrosinase is a kind of oxidoreducing enzyme, and tyrosinase oxidation can promote l-tyrosine to generate melanin, in junket
During propylhomoserin forms melanin, tyrosinase can promote l-tyrosine production L-3,4 dihydroxyphenylalanine and further act on to make L-3,4 dihydroxyphenylalanine shape
At a bar quinone, DOPA quinone ultimately generates melanin.
The calculation formula of inhibiting rate: [1- (T2-T1)/(C2-C1)] * 100%
C1 is the absorbance value of buffer solution and tyrosinase extracting solution, and C2 indicates the absorbance value of the melanin generated,
It is C2-C1 using the absorbance value that C1 surveys C2 as reference, indicates to generate after the absorbance for deducting tyrosinase extracting solution black
The absorbance value of pigment.T1 is the absorbance value that sample, tyrosinase extracting solution and buffer solution is added, and T2 is pressed down by sample
The absorbance value of the melanin generated after system, similarly obtains T2-T1 by the absorbance value that reference surveys T2 of T1, and expression is being deducted
Under the influence of sample and tyrosinase extracting solution absorbance, the absorbance value of the melanin after the inhibition of sample.Embodiment 1
Inhibiting rate result such as table 3 institute of the sample solution obtained to embodiment 6 and comparative example 1 in tyrosinase inhibitory activity measurement
Show:
Show the beauty containing Noni fruit essential oil that embodiment 1 is obtained to embodiment 6 by the test result of above-mentioned inhibiting rate
White suncream is strong to tyrosinase rejection ability, can be used for skin-whitening.Especially, the inhibiting rate highest of embodiment 6 is implemented
Example 3 is taken second place.When illustrating that Noni fruit essential oil weight part ratio is 1 part, Whitening sunscreen cream is to most strong to tyrosinase rejection ability.And it is real
The benefits of example 6 plays collaboration to tyrosinase inhibitory action compared to the component of embodiment more than 3 is applied, and comparative example 1 does not contain Noni fruit
The frost of essential oil inhibits poor to tyrosinase.Show that Noni fruit essential oil has preferable tyrosinase activity rejection ability, Nuo Li
There is fruit essential oil whitening sun protection effect can be used for preparing Whitening sunscreen cream.
Four, inhibit the animal model test of melanin growth
Zebra fish is a kind of in vitro fertilization, blastoprolepsis model animal, has been widely used in genetic development at present,
The multiple fields such as environmental monitoring.The model is also widely used for the influence that assessment compound grows melanin at present.Collect spot
Horse fish embryo is put into 96 orifice plates, 4 pieces of every hole embryo, and sample liquid prepared by embodiment 6 is added in 6hpf, and 72h observes zebra
Fish pigment growing state.Fig. 1 is sample liquid to zebrafish embryo pigment growth inhibition situation, and wherein A is normal zebrafish embryo,
B is influence of 6 sample liquid of embodiment to pigment.It is found from Fig. 1, the case where zebra fish normal relative to A, the pigment of B subtracts significantly
It is few, show that 6 sample liquid of embodiment inhibits the effect of melanin growth very good, illustrates the beauty of the invention containing Noni fruit essential oil
White suncream can inhibit melanin growth, play white-skinned face function.
In conclusion a kind of Whitening sunscreen cream containing Noni fruit essential oil of the invention, has significant DPPH free radical
Scavenging activity effectively inhibits the activity of tyrosinase, inhibits melanin growth, good to ultraviolet radiation absorption effect, realizes that whitening is anti-
Shine the effect of skin care.And the preparation method of Whitening sunscreen cream of the present invention is simple to operation, lower production costs, wherein benefit
Noni fruit essential oil is made with distillation under vacuum and atmospheric distillation, it is best in quality, there is preferable DPPH radical scavenging activity
Power, may be directly applied to skin care whitening, also can be applied to prepare other skin-lightening cosmetics or skin care item product.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should be included within the scope of the present invention.
Claims (9)
1. a kind of Whitening sunscreen cream containing Noni fruit essential oil, which is characterized in that including following raw material components: Noni fruit essential oil,
Jojoba oil, sterol ester, vitamin E, methylparaben, ethylparaben, amino acid humectant, allantoin, deionized water；
Wherein, jojoba oil, sterol ester, vitamin E, methylparaben, the raw material that ethylparaben is A phase；Amino acid moisturizing
Agent, allantoin, the raw material that deionized water is B phase；Noni fruit essential oil is the raw material of D phase；
The weight part ratio of the raw material are as follows: 0.8~1.2 part of Noni fruit essential oil, 1~1.2 part of jojoba oil, sterol ester 0.8~1
Part, 0.5~1 part of vitamin E, 0.1~0.3 part of methylparaben, 0.05~0.15 part of ethylparaben, amino acid humectant 2
~3 parts, 0.2~0.4 part of allantoin, 90~110 parts of deionized water.
2. a kind of Whitening sunscreen cream containing Noni fruit essential oil according to claim 1, which is characterized in that the raw material is also
Including lauryl alcohol, tristerin, 16/18 natural fatty alcohols, caprylic/capric triglyceride, isononyl isononanoate,
Dimethyl silicone polymer, glycerol；
Wherein, tristerin, 16/18 natural fatty alcohols, caprylic/capric triglyceride, isononyl isononanoate, flash
Bar oil, dimethyl silicone polymer, sterol ester, vitamin E, methylparaben, the raw material that ethylparaben is A phase；Glycerol, amino
Sour moisturizer, allantoin, the raw material that deionized water is B phase；Lauryl alcohol is the raw material of C phase；Noni fruit essential oil is the original of D phase
Material.
3. a kind of Whitening sunscreen cream containing Noni fruit essential oil according to claim 2, which is characterized in that the raw material
Weight part ratio are as follows: 0.8~1.2 part of Noni fruit essential oil, 1~1.2 part of jojoba oil, 0.8~1 part of sterol ester, vitamin E 0.5~
1 part, 0.1~0.3 part of methylparaben, 0.05~0.15 part of ethylparaben, 2~3 parts of amino acid humectant, allantoin 0.2
~0.4 part, 90~110 parts of deionized water, 0.7~0.9 part of lauryl alcohol, 1~1.5 part of tristerin, 16/18 days
Right 0.4~0.6 part of fatty alcohol, 2~3 parts of caprylic/capric triglyceride, 3~5 parts of isononyl isononanoate, dimethyl silicone polymer
0.5~1 part, 3~5 parts of glycerol.
4. a kind of Whitening sunscreen cream containing Noni fruit essential oil according to claim 2, which is characterized in that the raw material
Weight part ratio are as follows: 1 part of Noni fruit essential oil, 1~1.2 part of jojoba oil, 0.8~1 part of sterol ester, 0.5~1 part of vitamin E, Buddhist nun
Moor 0.2 part of tortoise beetle ester, 0.1 part of ethylparaben, 2~3 parts of amino acid humectant, 0.3 part of allantoin, deionized water 90~110
Part, 0.8 part of lauryl alcohol, 1~1.5 part of tristerin, 0.5 part of 16/18 natural fatty alcohol, caprylic/capric glycerol
Three 2~3 parts of esters, 3~5 parts of isononyl isononanoate, 0.5~1 part of dimethyl silicone polymer, 3~5 parts of glycerol.
5. a kind of Whitening sunscreen cream containing Noni fruit essential oil according to claim 1, which is characterized in that the Noni fruit
The preparation method of essential oil is put into distiller, connection is taken out the following steps are included: the fresh Noni fruit of chopping is mixed with distilled water
Air pump, is evaporated under reduced pressure 2~4h, and the volatile oil of acquisition is Noni fruit essential oil.
6. a kind of Whitening sunscreen cream containing Noni fruit essential oil according to claim 1, which is characterized in that the Noni fruit
The preparation method of essential oil is put into distiller, normal pressure steams the following steps are included: the fresh Noni fruit of chopping is mixed with distilled water
2~4h of reflux is evaporated, gained phegma is stood, extracts phegma supernatant liquid to get Noni fruit essential oil.
7. a kind of Whitening sunscreen cream containing Noni fruit essential oil according to claim 5 or 6, which is characterized in that the steaming
The volume of distilled water is that 150ml distilled water is added in each hectogram Noni fruit.
8. a kind of preparation method of Whitening sunscreen cream containing Noni fruit essential oil according to claim 1, which is characterized in that
The following steps are included:
(1) prepare the raw material of A phase, B phase, D phase；
(2) A phase, B phase are deployed: preparing A phase, B phase respectively, and difference heating stirring is in homogeneous to 80~90 DEG C；
(3) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and controls the temperature range of A phase and B phase at 80~90 DEG C
Between, A phase is slowly added in B phase, under 800~1200 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 40~50 DEG C, D phase is added, lasting to stir, cream
Liquid is down to room temperature, stops stirring, stands 18~24 hours, and the Whitening sunscreen cream containing Noni fruit essential oil is made.
9. according to a kind of described in any item preparation methods of the Whitening sunscreen cream containing Noni fruit essential oil of claim 2,3,4,
Characterized by comprising the following steps:
(1) prepare the raw material of A phase, B phase, C phase, D phase；
(2) A phase, B phase are deployed: preparing A phase, B phase respectively, and difference heating stirring is in homogeneous to 80~90 DEG C；
(3) mixing preparation: the temperature for adjusting B phase is higher than the temperature of A phase, and controls the temperature range of A phase and B phase at 80~90 DEG C
Between, A phase is slowly added in B phase, under 800~1200 rev/min states of stirring until two-phase is complete by the two-phase temperature difference≤5 DEG C
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60~70 DEG C, C phase is added, starts homogeneous again
Machine, until lotion is uniformly mixed；When temperature is down to 40~50 DEG C, D phase is added, lasting to stir, lotion is down to room temperature, stops stirring
It mixes, stands 18~24 hours, the Whitening sunscreen cream containing Noni fruit essential oil is made.
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| CN108096115B (en) * | 2018-01-18 | 2020-12-11 | 玉环市粢醍化妆品有限公司 | Plant essence sunscreen cream and preparation method thereof |
| CN109984960A (en) * | 2019-05-07 | 2019-07-09 | 海南师范大学 | A kind of beautiful essential oil facial cleanser of promise and preparation method thereof |
| CN113974039B (en) * | 2021-07-30 | 2023-10-17 | 海南师范大学 | Noni fruit ferment free of peculiar smell and preparation method thereof |
| CN114632038B (en) * | 2022-02-17 | 2023-12-29 | 广州丸美生物科技有限公司 | Whitening sun-screening skin care matrix and preparation method thereof, and cosmetics and preparation method thereof |
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