CN106109523A - A kind of crocin and Carlina acaulis composite chewable tablet and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of crocin and Carlina acaulis composite chewable tablet and preparation method thereof, its raw material includes Carlina acaulis lyophilized powder 0.4～3 parts according to the mass fraction, crocin 0.05～0.6 part, lactose 18～28 parts, glucose 3～8 parts, mannitol 1～5 parts, vitamin C 3～8 parts, magnesium stearate 0.2～0.4 part, and use the ethanol solution of 3% polyvinylpyrrolidone to do binding agent.The composite chewable tablet that the present invention prepares presents natural rufous, and without sucrose, cool taste is sour-sweet, has fresh scent.Stigma Croci and the most protected liver of Carlina acaulis, the effect of the cholesterol that enhances metabolism, reduces, combine the two, and uses the form of chewable tablet, improves the health-care effect of the two further.

Description

A compound chewable tablet of saffron and artichoke and preparation method thereof

technical field

The invention belongs to the field of pharmaceutical preparations, and in particular relates to a compound chewable tablet of saffron and artichoke and a preparation method thereof.

Background technique

The liver is an important organ that maintains the metabolism of the human body. It plays an important role in biosynthesis, biotransformation, detoxification, secretion, excretion, and immunity. Emotions, sleep, diet, and even drugs all affect the catharsis function of the liver. With the change of lifestyle and the improvement of nutritional level, liver disease has become one of the major diseases that threaten health. Its causes are various, and it is a long-term accumulation and latent process. Once the liver is damaged, it is difficult to fully recover. At present, liver diseases are generally treated after the onset of the disease, mainly using methods such as drug therapy, chemotherapy, surgical resection, and surgical transplantation. Therefore daily hepatoprotective and hepatoprotective seem particularly important, need badly a kind of easy to take, good medicine or health product of preventive health care effect.

Contents of the invention

The purpose of the present invention is to overcome the deficiencies of the prior art, and provide a compound chewable tablet of saffron and artichoke and its preparation method. The chewable tablet obtained has the dual health effects of artichoke and saffron, and has a sour taste. Sweet, nutritious, sucrose-free, and unique in flavor.

One of the technical solutions adopted by the present invention to solve its technical problems is:

A method for preparing a compound chewable tablet of saffron and artichoke. The raw materials thereof include 0.4 to 3 parts of artichoke freeze-dried powder, 0.05 to 0.6 parts of saffron, 18 to 28 parts of lactose, and 3 to 8 parts of glucose in parts by mass. 1 to 5 parts of mannitol, 3 to 8 parts of vitamin C, and 0.2 to 0.4 parts of magnesium stearate; the preparation method comprises:

1) Take artichoke stem and leaf powder with a particle size of 10-30 mesh, add 8-25 times the amount (mass volume ratio) of water, extract with 180-320W microwave for 50-200s, and concentrate the extract to 18-27 degrees Baume , Separation and purification with macroporous adsorption resin: load the sample according to the volume flow rate of 3-6BV/h, elute with 2-6BV of 45-55% ethanol, and the elution rate is 3-6BV/h, and the obtained eluate is concentrated to After 38-47 degrees Baume, freeze-dry for 45-75 hours to obtain freeze-dried artichoke powder, wherein the content of artichoke acid is 4.5-6.0%;

2) Take the dried fruit powder of Gardenia grandiflora with a particle size of 10 to 30 meshes, add 8 to 25 times the amount of deionized water containing 0.5 to 1.5% co-solvent at room temperature, and extract twice at 45 to 55 ° C, each time Extract for 22-26 hours; combine the extracts, centrifuge at 2500-5500rpm for 5-45min to remove impurities, filter with a microfiltration membrane with a pore size of 4-6μm at room temperature and 0.08-0.6MPa, and then filter at room temperature and 0.04-0.15MPa Further filter with a hollow fiber ultrafiltration membrane with a molecular weight cut-off of 8000-15000D; after the filtrate is adsorbed to a saturated macroporous resin column, it is sequentially eluted with deionized water for 3-6BV to remove impurities, and 15-35% alcohol for 3-6BV to remove For substances with higher polarity, the target substance is eluted with 35-95% alcohol 4-6BV; the eluate containing the target substance is concentrated and spray-dried to obtain saffron with a purity of 65-80%;

3) Pulverize lactose, glucose, mannitol and vitamin C and pass through a 110-130 mesh sieve for later use; take 0.4-3 parts of artichoke freeze-dried powder obtained in step 1), 0.05-0.6 parts of crocin obtained in step 2) and the above-mentioned Mix 18-28 parts of lactose, 3-8 parts of glucose, 1-5 parts of mannitol, and 3-8 parts of vitamin C;

4) making a soft material from the mixed material obtained in step 3) with an absolute ethanol solution containing 2 to 4% polyvinylpyrrolidone;

5) Pass the soft material through a 10-30 mesh sieve, spread it on a tray, dry it at 45-70°C, and then sieve it through a 14-18 mesh sieve;

6) Add 0.2 to 0.4 parts of magnesium stearate to the granules obtained in step 5), mix well, and press into tablets to obtain the compound chewable tablet of crocin and artichoke, wherein the contents of crocin and cynic acid are respectively 0.25-1.50% and 0.08-0.4%.

In one embodiment: in the step 3), 0.4-0.6 parts of artichoke freeze-dried powder, 0.05-0.15 parts of crocin, 19-21 parts of lactose, 4-6 parts of glucose, and 1-6 parts of mannitol 3 parts, vitamin C is 3 to 5 parts.

In one embodiment: in the step 3), 1 to 3 parts of artichoke freeze-dried powder, 0.4 to 0.6 parts of crocin, 24 to 26 parts of lactose, 6 to 8 parts of glucose, and 3 to 8 parts of mannitol 5 parts, vitamin C is 5 to 7 parts.

In one embodiment: in the step 3), 1-2 parts of artichoke freeze-dried powder, 0.2-0.4 parts of crocin, 22-24 parts of lactose, 5-7 parts of glucose, and 2-2 parts of mannitol 4 parts, vitamin C is 4 to 6 parts.

In one embodiment: in the step 3), 0.5-1.5 parts of artichoke freeze-dried powder, 0.1-0.3 parts of crocin, 22-24 parts of lactose, 6-7 parts of glucose, and 2-2 parts of mannitol 3 parts, vitamin C is 4 to 6 parts.

In one embodiment: in the step 3), the artichoke freeze-dried powder is 0.5-1.5 parts, crocin is 0.1-0.3 parts, lactose is 21-23 parts, glucose is 5-7 parts, and mannitol is 1-23 parts. 3 parts, vitamin C is 4 to 5 parts.

Two of the technical solutions adopted by the present invention to solve the technical problems are:

A saffron and artichoke compound chewable tablet prepared according to the above preparation method.

Compared with the background technology, this technical solution has the following advantages:

Crocetin has the function of protecting the liver and promoting gallbladder, can improve microcirculation, promote the secretion and excretion of bile, reduce abnormally high globulin and total bilirubin, reduce cholesterol and increase fat metabolism, and can prevent early acute liver damage caused by toxic substances. Has chemopreventive effect. Artichoke can enhance the function of the liver, and has the effects of low fat, beauty and beauty. The artichoke acid contained in the stems and leaves of the artichoke can protect the liver, promote diuresis and detoxification, prevent arteriosclerosis, and protect the cardiovascular system. The combined application of saffron and artichoke can synergize, and can better exert the health effects of protecting the liver, promoting metabolism, and lowering cholesterol. The present invention makes the two preparations into chewable tablets, which is convenient to take, can be swallowed, chewed, sucked, or dispersed with water; the surface area of the tablets increases after being chewed, which can promote the dissolution and absorption of drugs in the body, and improve the quality of saffron. The bioavailability of vitamins and artichokes can be taken on time even in the state of water shortage, especially suitable for the elderly, children, stroke patients, patients with difficulty in swallowing and poor gastrointestinal function, and can reduce the burden of drugs on the gastrointestinal tract ; And this product does not contain sucrose, is rich in vitamin C, has a good taste, and is suitable for all ages. It is a rare good product for health care.

detailed description

Below by embodiment the content of the present invention is specified:

Example 1

A composite chewable tablet of saffron and artichoke, whose raw materials are calculated in parts by mass, including 0.5 parts of artichoke freeze-dried powder, 0.1 part of saffron, 20 parts of lactose, 5 parts of glucose, 2 parts of mannitol, and 4 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 10 times the amount of water, extract with 250W microwave for 60s, and inhale the extract into the external circulation After concentrating in a vacuum concentrator to 20-25 degrees Baume, use D101 macroporous adsorption resin for separation and purification: load the sample according to the volume flow rate of 4BV/h, elute with 3BV of 50% ethanol, and the elution rate is 4BV/h. The obtained eluate was inhaled into the external circulation decompression concentrator again and concentrated to 40-45 degrees Baume, and then freeze-dried for 48 hours to obtain freeze-dried artichoke powder, wherein the content of the active ingredient artichoke acid was 5.2%;

2) Take the dried fruit of Gardenia grandiflora that has been cleaned and removed, crush it to a particle size of 20 mesh, add 10 times the amount of deionized water containing 1% co-solvent Tween 80 at room temperature, and extract twice at 50 ° C. 24 hours; the extracts were combined, centrifuged at 4000rpm for 30min to remove impurities, then filtered with PP cotton microfiltration membrane with a pore size of 5μm at room temperature and 0.1-0.5MPa, and then filtered with a hollow membrane with a molecular weight cut-off of 10000D at room temperature and 0.05-0.1MPa Fibrous ultrafiltration membrane is further filtered; after the filtrate is saturated with AB-8 macroporous resin, 5BV is eluted with deionized water successively to remove impurities, 5BV is eluted with 20-30% ethanol to remove more polar substances, and then used 40-90% ethanol elutes 5BV to elute the target substance; the eluate containing the target substance is concentrated and spray-dried to obtain saffron with a purity of 78%;

3) After pulverizing lactose, glucose, mannitol and vitamin C with a pulverizer, pass through a 120-mesh sieve for later use; take 0.5 part of artichoke freeze-dried powder obtained in step 1), 0.01 part of saffron obtained in step 2) and 20 parts of the above-mentioned lactose 5 parts of glucose, 2 parts of mannitol, and 4 parts of vitamin C are put into the mixer and mixed evenly;

4) Mix the mixed material obtained in step 3) evenly with an anhydrous ethanol solution containing 3% polyvinylpyrrolidone to make a soft material, which can be formed into a ball by hand kneading and disperse when lightly pressed to be a qualified soft material standard ;

5) After the soft material passes through a 20-mesh sieve, spread it evenly on the enamel plate, send it to an oven for drying at 50-65°C, and pass the dried granules through a 16-mesh sieve for granulation;

6) To step 5) granulate, add 0.3 parts of magnesium stearate to the obtained granules, mix evenly, and put it into a rotary tablet press for tableting, to obtain the crocin and artichoke compound chewable tablets, wherein crocin and artichoke The content of thistle acid is 0.26% and 0.086%, respectively.

Example 2

A compound chewable tablet of saffron and artichoke, its raw materials are calculated in parts by mass, including 2 parts of freeze-dried artichoke powder, 0.5 parts of saffron, 25 parts of lactose, 7 parts of glucose, 4 parts of mannitol, and 6 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 15 times the amount of water, extract with 300W microwave for 120s, and inhale the extract into the external circulation After concentrating in a vacuum concentrator to 20-25 degrees Baume, use AB-8 type macroporous adsorption resin for separation and purification: according to the volume flow rate of 4BV/h, the sample is loaded, 4BV of 50% ethanol is eluted, and the elution rate is 4BV/h h, the obtained eluate was sucked into the external circulation decompression concentrator again and concentrated to 40-45 degrees Baume, and then freeze-dried for 48 hours to obtain freeze-dried artichoke powder, wherein the content of the active ingredient artichoke acid was 5.1%;

2) Take the dried fruit of Gardenia grandiflora that has been cleaned and removed, crush it to a particle size of 20 mesh, add 14 times the amount of deionized water containing 1% co-solvent Tween 80 at room temperature, and extract twice at 50 ° C. 24 hours; the extracts were combined, centrifuged at 4000rpm for 40min to remove impurities, then filtered with a PP cotton microfiltration membrane with a pore size of 5μm at room temperature and 0.1-0.5MPa, and then filtered with a hollow membrane with a molecular weight cut-off of 10000D at room temperature and 0.05-0.1MPa. Fibrous ultrafiltration membrane is further filtered; after the filtrate is saturated with AB-8 macroporous resin, 4BV is sequentially eluted with deionized water to remove impurities, and 5BV is eluted with 20-30% ethanol to remove polar substances. Eluting 5BV with 40-90% ethanol to elute the target substance; concentrating the eluate containing the target substance and spray drying to obtain saffron with a purity of 70%;

3) After pulverizing lactose, glucose, mannitol and vitamin C with a pulverizer, pass through a 120-mesh sieve for later use; take 2 parts of artichoke freeze-dried powder obtained in step 1), 0.5 part of saffron obtained in step 2) and 25 parts of the above-mentioned lactose 7 parts of glucose, 4 parts of mannitol, and 6 parts of vitamin C are put into the mixer and mixed evenly;

4) Mix the mixed material obtained in step 3) evenly with an anhydrous ethanol solution containing 3% polyvinylpyrrolidone to make a soft material, which can be formed into a ball by hand kneading and disperse when lightly pressed to be a qualified soft material standard ;

5) After the soft material passes through a 20-mesh sieve, spread it evenly on the enamel plate, send it to an oven for drying at 50-65°C, and pass the dried granules through a 16-mesh sieve for granulation;

6) To step 5) granulate, add 0.3 parts of magnesium stearate to the obtained granules, mix evenly, and put it into a rotary tablet press for tableting, to obtain the crocin and artichoke compound chewable tablets, wherein crocin and artichoke The content of thistle acid is 1.20% and 0.34%, respectively.

Example 3

A saffron and artichoke compound chewable tablet, the raw materials of which are calculated in parts by mass, include 1.5 parts of artichoke freeze-dried powder, 0.3 parts of saffron, 23 parts of lactose, 6 parts of glucose, 3 parts of mannitol, and 5 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 20 times the amount of water, extract with 200W microwave for 180s, and suck the extract into the external circulation Decompression concentrator, 5BV of 50% ethanol for elution, the elution rate is 4BV/h, the eluate obtained is sucked into the external circulation decompression concentrator again and concentrated to 40-45 degrees Baume, then freeze-dried for 72h to obtain Freeze-dried artichoke powder, wherein the content of active ingredient cynic acid is 5.6%;

2) Take the dried fruit of Gardenia grandiflora that has been cleaned and removed, crush it to a particle size of 20 mesh, add 15 times the amount of deionized water containing 1% co-solvent Tween 40 at room temperature, and extract twice at 50° C. 6 hours; the extracts were combined, centrifuged at 3000rpm for 20min to remove impurities, then filtered with PP cotton microfiltration membrane with a pore size of 5μm at room temperature and 0.1-0.5MPa, and then filtered with a hollow membrane with a molecular weight cut-off of 10000D at room temperature and 0.05-0.1MPa. Fibrous ultrafiltration membrane was further filtered; after the filtrate was saturated with D101 macroporous resin, 5BV was eluted with deionized water to remove impurities, 5BV was eluted with 20-30% ethanol to remove more polar substances, and then 40 ~90% ethanol elutes 5BV to elute the target substance; concentrate the eluate containing the target substance, and spray dry to obtain saffron with a purity of 75%;

3) After pulverizing lactose, glucose, mannitol and vitamin C with a pulverizer, pass through a 120-mesh sieve for later use; take 1.5 parts of artichoke freeze-dried powder obtained in step 1), 0.3 parts of saffron obtained in step 2) and 23 parts of the above-mentioned lactose 6 parts of glucose, 3 parts of mannitol, and 5 parts of vitamin C are put into the mixer and mixed evenly;

4) Mix the mixed material obtained in step 3) evenly with an anhydrous ethanol solution containing 3% polyvinylpyrrolidone to make a soft material, which can be formed into a ball by hand kneading and disperse when lightly pressed to be a qualified soft material standard ;

5) After the soft material passes through a 20-mesh sieve, spread it evenly on the enamel plate, send it to an oven for drying at 50-65°C, and pass the dried granules through a 16-mesh sieve for granulation;

6) To step 5) granulate, add 0.3 parts of magnesium stearate to the obtained granules, mix evenly, and put it into a rotary tablet press for tableting, to obtain the crocin and artichoke compound chewable tablets, wherein crocin and artichoke The content of thistle acid is 0.79% and 0.27%, respectively.

Example 4

A saffron and artichoke compound chewable tablet, its raw materials are calculated in parts by mass, including 1 part of artichoke freeze-dried powder, 0.2 parts of saffron, 23 parts of lactose, 6.5 parts of glucose, 2.5 parts of mannitol, and 5 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 15 times the amount of water, extract with 300W microwave for 60s, and inhale the extract into the external circulation After concentrating in a vacuum concentrator to 20-25 degrees Baume, use AB-8 type macroporous adsorption resin for separation and purification: according to the volume flow rate of 4BV/h, the sample is loaded, 3BV of 50% ethanol is eluted, and the elution rate is 4BV/h h, the obtained eluate was inhaled into the external circulation decompression concentrator again to concentrate to 40-45 degrees Baume, and then freeze-dried for 48 hours to obtain freeze-dried artichoke powder, wherein the content of the active ingredient artichoke acid was 4.9%;

2) Take the dried fruit of Gardenia grandiflora that has been cleaned and removed, crush it to a particle size of 20 mesh, add 15 times the amount of deionized water containing 1% co-solvent Tween 80 at room temperature, and extract twice at 50 ° C. 6h; the extracts were combined, centrifuged at 5000rpm for 10min to remove impurities, then filtered with a PP cotton microfiltration membrane with a pore size of 5μm at room temperature and 0.1-0.5MPa, and then filtered with a hollow membrane with a molecular weight cut-off of 10000D at room temperature and 0.05-0.1MPa. Fibrous ultrafiltration membrane was further filtered; after the filtrate was saturated with D101 macroporous resin, 4BV was eluted with deionized water to remove impurities, 4BV was eluted with 20-30% ethanol to remove more polar substances, and then 40 ~90% ethanol elutes 5BV to elute the target substance; the eluate containing the target substance is concentrated and spray-dried to obtain saffron with a purity of 73%;

3) After pulverizing lactose, glucose, mannitol and vitamin C with a pulverizer, pass through a 120-mesh sieve for later use; take 1 part of artichoke freeze-dried powder obtained in step 1), 0.2 part of saffron obtained in step 2) and 23 parts of the above-mentioned lactose 6.5 parts of glucose, 2.5 parts of mannitol, and 5 parts of vitamin C are put into the mixer and mixed evenly;

4) Mix the mixed material obtained in step 3) evenly with an anhydrous ethanol solution containing 3% polyvinylpyrrolidone to make a soft material, which can be formed into a ball by hand kneading and disperse when lightly pressed to be a qualified soft material standard ;

5) After the soft material passes through a 20-mesh sieve, spread it evenly on the enamel plate, send it to an oven for drying at 50-65°C, and pass the dried granules through a 16-mesh sieve for granulation;

6) To step 5) granulate, add 0.3 parts of magnesium stearate to the obtained granules, mix evenly, and put it into a rotary tablet press for tableting, to obtain the crocin and artichoke compound chewable tablets, wherein crocin and artichoke The content of thistle acid is 0.54% and 0.17%, respectively.

Example 5

A compound chewable tablet of saffron and artichoke, its raw materials are calculated in parts by mass, including 1 part of freeze-dried artichoke powder, 0.2 parts of saffron, 22 parts of lactose, 6 parts of glucose, 2 parts of mannitol, and 4.5 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 10 times the amount of water, extract with 300W microwave for 120s, and inhale the extract into the external circulation After concentrating in a vacuum concentrator to 20-25 degrees Baume, use D101 macroporous adsorption resin for separation and purification: load the sample at a volume flow rate of 5BV/h, and elute with 50% ethanol at a rate of 5BV/h. , the obtained eluate was sucked into the external circulation decompression concentrator again and concentrated to 40-45 degrees Baume, and then freeze-dried for 72 hours to obtain freeze-dried artichoke powder, wherein the content of the active ingredient artichoke acid was 5.0%;

2) Take the dried fruit of Gardenia grandiflora that has been cleaned and removed, crush it to a particle size of 20 mesh, add 20 times the amount of deionized water containing 1% co-solvent Tween 80 at room temperature, and extract twice at 50 ° C. 6h; the extracts were combined, centrifuged at 3000rpm for 30min to remove impurities, then filtered with a PP cotton microfiltration membrane with a pore size of 5μm at room temperature and 0.1-0.5MPa, and then filtered with a hollow membrane with a molecular weight cut-off of 10000D at room temperature and 0.05-0.1MPa. Fibrous ultrafiltration membrane is further filtered; after the filtrate is saturated with AB-8 macroporous resin, 4BV is sequentially eluted with deionized water to remove impurities, and 5BV is eluted with 20-30% ethanol to remove polar substances. Eluting 5BV with 40-90% ethanol to elute the target substance; concentrating the eluate containing the target substance and spray drying to obtain saffron with a purity of 67%;

3) After pulverizing lactose, glucose, mannitol and vitamin C with a pulverizer, pass through a 120-mesh sieve for later use; take 1 part of artichoke freeze-dried powder obtained in step 1), 0.2 part of crocin obtained in step 2) and 22 parts of the above-mentioned lactose 6 parts of glucose, 2 parts of mannitol, and 4.5 parts of vitamin C are put into the mixer and mixed evenly;

4) Mix the mixed material obtained in step 3) evenly with an anhydrous ethanol solution containing 3% polyvinylpyrrolidone to make a soft material, which can be formed into a ball by hand kneading and disperse when lightly pressed to be a qualified soft material standard ;

5) After the soft material passes through a 20-mesh sieve, spread it evenly on the enamel plate, send it to an oven for drying at 50-65°C, and pass the dried granules through a 16-mesh sieve for granulation;

6) To step 5) granulate, add 0.3 parts of magnesium stearate to the obtained granules, mix evenly, and put it into a rotary tablet press for tableting, to obtain the crocin and artichoke compound chewable tablets, wherein crocin and artichoke The content of thistle acid is 0.47% and 0.16%, respectively.

The appearance, mouthfeel, hardness, moisture, friability and other indicators of the saffron and artichoke compound chewable tablets obtained in Example 15 were tested, and the results are shown in the table below.

The above is only a preferred embodiment of the present invention, so the scope of the present invention cannot be limited accordingly, that is, the equivalent changes and modifications made according to the patent scope of the present invention and the content of the specification should still be covered by the present invention within range.

Claims (7)

1. A preparation method of saffron and artichoke compound chewable tablet, characterized in that: comprising: 1) Take artichoke stem and leaf powder with a particle size of 10-30 mesh, add 8-25 times the amount of water, extract with 180-320W microwave for 50-200s, concentrate the extract to 18-27 degrees Baume, and then absorb it with macropores Resin separation and purification: load the sample according to the volume flow rate of 3-6BV/h, elute with 2-6BV of 45-55% ethanol, the elution rate is 3-6BV/h, and the obtained eluate is concentrated to 38-47 Baume After drying, freeze-dry for 45-75 hours to obtain freeze-dried artichoke powder, wherein the content of artichoke acid is 4.5-6.0%; 2) Take the dried fruit powder of Gardenia grandiflora with a particle size of 10 to 30 meshes, add 8 to 25 times the amount of deionized water containing 0.5 to 1.5% co-solvent at room temperature, and extract twice at 45 to 55 ° C, each time Extract for 22-26 hours; combine the extracts, centrifuge at 2500-5500rpm for 5-45min to remove impurities, filter with a microfiltration membrane with a pore size of 4-6μm at room temperature and 0.08-0.6MPa, and then filter at room temperature and 0.04-0.15MPa Further filter with a hollow fiber ultrafiltration membrane with a molecular weight cut-off of 8000-15000D; after the filtrate is adsorbed to a saturated macroporous resin column, it is sequentially eluted with deionized water for 3-6BV to remove impurities, and 15-35% alcohol for 3-6BV to remove For substances with higher polarity, the target substance is eluted with 35-95% alcohol 4-6BV; the eluate containing the target substance is concentrated and spray-dried to obtain saffron with a purity of 65-80%; 3) Pulverize lactose, glucose, mannitol and vitamin C and pass through a 110-130 mesh sieve for later use; take 0.4-3 parts of artichoke freeze-dried powder obtained in step 1), 0.05-0.6 parts of crocin obtained in step 2) and the above-mentioned Mix 18-28 parts of lactose, 3-8 parts of glucose, 1-5 parts of mannitol, and 3-8 parts of vitamin C; 4) making a soft material from the mixed material obtained in step 3) with an absolute ethanol solution containing 2 to 4% polyvinylpyrrolidone; 5) Pass the soft material through a 10-30 mesh sieve, spread it on a tray, dry it at 45-70°C, and then sieve it through a 14-18 mesh sieve; 6) Add 0.2 to 0.4 parts of magnesium stearate to the granules obtained in step 5), mix well, and press into tablets to obtain the compound chewable tablet of crocin and artichoke, wherein the contents of crocin and cynic acid are respectively 0.25-1.50% and 0.08-0.4%. 2. The preparation method according to claim 1, characterized in that: in said step 3), 0.4-0.6 parts of artichoke freeze-dried powder, 0.05-0.15 parts of crocin, 19-21 parts of lactose, 19-21 parts of glucose, 4-6 parts for mannitol, 1-3 parts for mannitol, and 3-5 parts for vitamin C. 3. The preparation method according to claim 1, characterized in that: in said step 3), 1 to 3 parts of artichoke freeze-dried powder, 0.4 to 0.6 parts of crocin, 24 to 26 parts of lactose, 24 to 26 parts of glucose, 6-8 parts for mannitol, 3-5 parts for mannitol, and 5-7 parts for vitamin C. 4. The preparation method according to claim 1, characterized in that: in said step 3), 1-2 parts of artichoke freeze-dried powder, 0.2-0.4 parts of crocin, 22-24 parts of lactose, 22-24 parts of glucose, 5-7 parts for mannitol, 2-4 parts for mannitol, and 4-6 parts for vitamin C. 5. The preparation method according to claim 1, characterized in that: in said step 3), 0.5-1.5 parts of artichoke freeze-dried powder, 0.1-0.3 parts of crocin, 22-24 parts of lactose, 22-24 parts of glucose, 6-7 parts for mannitol, 2-3 parts for mannitol, and 4-6 parts for vitamin C. 6. The preparation method according to claim 1, characterized in that: in said step 3), 0.5-1.5 parts of artichoke freeze-dried powder, 0.1-0.3 parts of crocin, 21-23 parts of lactose, 21-23 parts of glucose, 5-7 parts for mannitol, 1-3 parts for mannitol, and 4-5 parts for vitamin C. 7. A compound chewable tablet of saffron and artichoke prepared by the preparation method according to any one of claims 1 to 6.