CN106070276A - A kind of pyraclostrobin and Tebuconazole compound suspending agent and preparation method thereof - Google Patents
A kind of pyraclostrobin and Tebuconazole compound suspending agent and preparation method thereof Download PDFInfo
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- CN106070276A CN106070276A CN201610723692.1A CN201610723692A CN106070276A CN 106070276 A CN106070276 A CN 106070276A CN 201610723692 A CN201610723692 A CN 201610723692A CN 106070276 A CN106070276 A CN 106070276A
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- Prior art keywords
- pyraclostrobin
- tebuconazole
- suspending agent
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- parts
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- 239000005839 Tebuconazole Substances 0.000 title claims abstract description 36
- 239000005869 Pyraclostrobin Substances 0.000 title claims abstract description 33
- HZRSNVGNWUDEFX-UHFFFAOYSA-N pyraclostrobin Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NN(C=2C=CC(Cl)=CC=2)C=C1 HZRSNVGNWUDEFX-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000000375 suspending agent Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- -1 Tebuconazole compound Chemical class 0.000 title claims abstract description 16
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000000227 grinding Methods 0.000 claims abstract description 8
- 238000004458 analytical method Methods 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000000084 colloidal system Substances 0.000 claims abstract description 4
- 239000004576 sand Substances 0.000 claims abstract description 4
- 238000003860 storage Methods 0.000 claims abstract description 4
- 238000001914 filtration Methods 0.000 claims description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 abstract description 10
- 229920000056 polyoxyethylene ether Polymers 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 206010039509 Scab Diseases 0.000 abstract description 6
- 241000209140 Triticum Species 0.000 abstract description 6
- 235000021307 Triticum Nutrition 0.000 abstract description 6
- 230000009471 action Effects 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 239000013530 defoamer Substances 0.000 abstract description 5
- 239000008367 deionised water Substances 0.000 abstract description 5
- 229910021641 deionized water Inorganic materials 0.000 abstract description 5
- 230000002265 prevention Effects 0.000 abstract description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 abstract description 5
- 235000010234 sodium benzoate Nutrition 0.000 abstract description 5
- 239000004299 sodium benzoate Substances 0.000 abstract description 5
- 229920001285 xanthan gum Polymers 0.000 abstract description 5
- 229940082509 xanthan gum Drugs 0.000 abstract description 5
- 235000010493 xanthan gum Nutrition 0.000 abstract description 5
- 239000000230 xanthan gum Substances 0.000 abstract description 5
- HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 18
- 238000012360 testing method Methods 0.000 description 14
- 231100000419 toxicity Toxicity 0.000 description 10
- 230000001988 toxicity Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 230000001154 acute effect Effects 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 6
- 238000005338 heat storage Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000001018 virulence Effects 0.000 description 5
- XBHJTSIYYWRJFQ-MDZDMXLPSA-N 3-[(e)-2-phenylethenyl]phenol Chemical compound OC1=CC=CC(\C=C\C=2C=CC=CC=2)=C1 XBHJTSIYYWRJFQ-MDZDMXLPSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 description 4
- 229960002669 albendazole Drugs 0.000 description 4
- 210000003128 head Anatomy 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- QXMNTPFFZFYQAI-IMDKZJJXSA-N beta-sitosterol 3-O-beta-D-glucopyranoside Natural products CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)O[C@@H]5C[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)C QXMNTPFFZFYQAI-IMDKZJJXSA-N 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- NPJICTMALKLTFW-OFUAXYCQSA-N daucosterol Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NPJICTMALKLTFW-OFUAXYCQSA-N 0.000 description 2
- QDFKFNAHVGPRBL-UHFFFAOYSA-N daucosterol Natural products CCC(CCC(C)C1CCC2C1CCC3C2(C)CC=C4CC(CCC34C)OC5OC(CO)C(O)C(O)C5O)C(C)C QDFKFNAHVGPRBL-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 235000010603 pastilles Nutrition 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 240000000385 Brassica napus var. napus Species 0.000 description 1
- 241000252229 Carassius auratus Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 241000233679 Peronosporaceae Species 0.000 description 1
- 241000221662 Sclerotinia Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 108010091371 endoglucanase 1 Proteins 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 206010023683 lagophthalmos Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002068 microbial inoculum Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 231100001224 moderate toxicity Toxicity 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 239000003895 organic fertilizer Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000200 toxicological information Toxicity 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A kind of pyraclostrobin and Tebuconazole compound suspending agent and preparation method thereof, relate to wheat scab Prevention Technique field.At least by pyraclostrobin 10 parts, Tebuconazole 30 parts, fatty alcohol-polyoxyethylene ether 3 parts, styrylphenol polyoxyethylene ether 3 parts, xanthan gum 0.3 part, sodium benzoate 0.4 part, defoamer 0.3 part with complement to the deionized water of 100 parts and make.By after all raw material suction preparation still mix and blend through grinding at the beginning of colloid mill, then through sand mill fine grinding, sample analysis, qualified after filter, measure, pack, put in storage.The present invention with 1:3 proportioning mixed compound 40% time pyraclostrobin and Tebuconazole compound suspending agent, can play notable synergistic sphere of action, and the preparation that other proportioning is used with, all be unable to reach notable synergistic sphere of action.
Description
Technical field
The present invention relates to wheat scab Prevention Technique field, be specifically related to a kind of pyraclostrobin and Tebuconazole compounds
Suspending agent and preparation method thereof.
Background technology
At present, the existing bactericidal composition for preventing and treating wheat scab, such as Chinese patent CN 105439727 A
Disclosing one and " prevent and treat wheat scab biological organic fertilizer ", its raw material includes by weight: crop material 30～40 parts, Chinese medicine
Medicinal residues 40～60 parts, function bacterium 3～5 parts, carbamide 1～6 parts, stalk fermentation microbial inoculum 0.5～2.5 parts, cellulase 1～2 parts, red
Sugar 0.5～2 part.Separately there is Chinese patent CN 104106580 A to disclose one and " prevent and treat the compound disinfectant of wheat scab ",
With albendazole and Tebuconazole as base material, formulated according to the quality proportioning of albendazole Yu Tebuconazole 7: 1～1: 7.Excellent
The albendazole of choosing and Tebuconazole quality proportioning are 1: 2.Albendazole is the bactericide original drug of mass fraction 97%, and Tebuconazole is
The bactericide original drug of mass fraction 98.43%.
Inventor verifies through long term test, and these above-mentioned several bactericidal compositions are primarily present following defect:
1), by concrete proportionings several disclosed in above-mentioned several bactericidal compositions are tested, find gibberella saubinetii
Sick preventing and treating cannot play good prevention effect.
2), for several dosage forms disclosed in above-mentioned several bactericidal compositions, find all to there is difference through verification experimental verification
The defect of problem.Such as, wettable powder easily causes product to bond, and is difficult in water dispersion and suspends, or blocking shower nozzle, in spray
The phenomenon such as reason precipitation in day with fog, causes sprinkling irregular.
3), problem is compounded, by concrete proportionings several disclosed in above-mentioned several bactericidal compositions are carried out virulence test, heat
Storage stability test and mixture co-toxicity coefficient measure and find, are all unable to reach obvious potentiation.
Summary of the invention
An object of the present invention is to provide a kind of pyraclostrobin and Tebuconazole to compound suspending agent, and this suspending agent designs
Rationally, good to the prevention effect of wheat scab, and the notable synergistic effect of pyraclostrobin and Tebuconazole can be realized.
For achieving the above object, present invention employs techniques below scheme:
A kind of pyraclostrobin and Tebuconazole compound suspending agent, are made up of following components according to weight portion:
Pyraclostrobin is New-type wide-spectrum antibacterial.There is protection, treatment, blade infiltration conduction.General spray medicine 3
Secondary, interval 10d sprays 1 medicine.Spray medicine number of times is depending on the state of an illness.To Fructus Cucumidis sativi, Fructus Musae safety, have no that poisoning occurs.The mechanism of action: for
Mitochondrial respiratory inhibitor, i.e. by stoping electron transfer at cytochrome in synthesizing.There is protection, treatment, blade infiltration biography
Lead effect.Show powdery mildew of cucumber, downy mildew and banana freckle, leaf spot, sclerotiniose etc. through field control effectiveness test result
There is preferable prevention effect.
Tebuconazole be a kind of efficiently, wide spectrum, interior absorption triazole bactericidal agent, there is protection, treat, root out three zones,
Fungicidal spectrum is wide, the lasting period is long.This product is used for preventing and treating sclerotinia rot of colza, and not only preventive effect is good, and has resistant to lodging, and production-increasing function is bright
The feature such as aobvious.Mechanism of action to pathogenic bacteria is to suppress the demethylation of ergosterol on its cell membrane so that pathogenic bacteria cannot be formed
Cell membrane, thus kill pathogenic bacteria.
Pyraclostrobin and the Tebuconazole of the present invention compound suspending agent, and its beneficial effect shows:
1), suspending agent prepared by the present invention is in the side such as suspensibility, persistent foamability, wet screening test etc. and heat storage stability
Face is significantly better than that the product prepared by other proportionings.
2), mixed with 1:3 proportioning by experimental verification, pyraclostrobin and Tebuconazole compounded 40% time pyrazoles ether
Bacterium ester and Tebuconazole compound suspending agent, can play notable synergistic sphere of action, and the preparation that other proportioning is mixed, all it is unable to reach
Notable synergistic sphere of action.Meanwhile, the actual toxicity of different ratio does not promote along with the enhancing of theoretical toxicity, actual toxicity
And between theoretical toxicity, there is no regular change.
Another object of the present invention is to the preparation method providing a kind of pyraclostrobin and Tebuconazole to compound suspending agent, will
Through grinding at the beginning of colloid mill after raw material suction preparation still mix and blend, then through sand mill fine grinding, sample analysis, qualified rear filtration, meter
Measure, pack, put in storage.
The pyraclostrobin of the present invention and Tebuconazole compound the preparation method of suspending agent, and preparation technology is relatively simple, it is easy to
Industrialized production.
Detailed description of the invention
Below with reference to embodiment, the present invention is described in detail.But, embodiment content is only to this
Bright example and explanation, described specific embodiment is done various repairing by affiliated those skilled in the art
Change or supplement or use similar mode to substitute, without departing from the design of invention or surmount defined in the claims
Scope, all should belong to protection scope of the present invention.
One, pyraclostrobin and Tebuconazole compound the preparation of suspending agent, and the suspending agent prepared by each embodiment is each
The item testing result of technical specification, heat storage stability result of the test.
Embodiment 1
40% pyraclostrobin and Tebuconazole compound suspending agent, and each component and weight proportion thereof are as follows:
| Composition | Weight portion |
| Pyraclostrobin | 10 |
| Tebuconazole | 30 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 3 |
| Xanthan gum | 0.3 |
| Sodium benzoate | 0.4 |
| Defoamer | 0.3 |
| Deionized water | 53 |
Preparation method: through grinding at the beginning of colloid mill after raw material suction is prepared still mix and blend, then through sand mill fine grinding, sampling
Analyze, qualified after filter, measure, pack, put in storage.
Embodiment 2
39% pyraclostrobin and Tebuconazole compound suspending agent, and each component and weight proportion thereof are as follows:
| Composition | Weight portion |
| Pyraclostrobin | 10 |
| Tebuconazole | 29 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 3 |
| Xanthan gum | 0.3 |
| Sodium benzoate | 0.4 |
| Defoamer | 0.3 |
| Deionized water | 54 |
Preparation method is with embodiment 1.
Embodiment 3
38% pyraclostrobin and Tebuconazole compound suspending agent, and each component and weight proportion thereof are as follows:
Preparation method is with embodiment 1.
Embodiment 4
41% pyraclostrobin and Tebuconazole compound suspending agent, and each component and weight proportion thereof are as follows:
| Composition | Weight portion |
| Pyraclostrobin | 11 |
| Tebuconazole | 30 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 3 |
| Xanthan gum | 0.3 |
| Sodium benzoate | 0.4 |
| Defoamer | 0.3 |
| Deionized water | 52 |
Preparation method is with embodiment 1.
Embodiment 5
42% pyraclostrobin and Tebuconazole compound suspending agent, and each component and weight proportion thereof are as follows:
Preparation method is with embodiment 1.
Embodiment 6
40% pyraclostrobin and Tebuconazole compound suspending agent, and each component and weight proportion thereof are as follows:
| Composition | Weight portion |
| Pyraclostrobin | 10 |
| Tebuconazole | 30 |
| Daucosterol | 0.6 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 3 |
| Xanthan gum | 0.3 |
| Sodium benzoate | 0.4 |
| Defoamer | 0.3 |
| Deionized water | 52.4 |
Preparation method is with embodiment 1.
Pyraclostrobin and Tebuconazole prepared by embodiment 1～6 compound suspending agent, the detection of product all technical
Result is as shown in table 1, and product heat storage stability result of the test is as shown in table 2.
16 embodiments of table prepare the testing result of product all technical
26 embodiments of table prepare product heat storage stability result of the test
By table 1 and 2 it can be seen that the product of embodiment 1 and 6 preparation is in suspensibility, persistent foamability, wet screening test etc.
And the aspect such as heat storage stability is significantly better than that the product prepared by other embodiments.
Two, toxicological information
Pyraclostrobin: rat acute per os LD50For 5000mg/kg, acute percutaneous LD50For the acute suction of 2000mg/kg.
Enter LC50(4h) it is 0.3lmg/L；To lagophthalmos eyeball, no skin irritation: guinea pig skin sensitization test (STT) result is without sensitization: rat
3 months sub-chronic feeding test maximum no-effect doses: male rat is 9.2mg/kg/d, and female rats is 12.9mg/kg/d.
Tebuconazole: rat acute per os LD50For 4000mg/kg, male chmice acute per os LD50About 2000mg/kg is female little
Mus acute oral LD50For 3933mg/kg, rat acute percutaneous LD50>5000mg/kg.Rat acute sucks LC50(4h)>
0.8mg/L air (aerosol), > 5.1mg/L (powder).This medicine is to fish moderate toxicity, Carassius auratus LC50(96 hours) are 8.7mg/L.
Three, pyraclostrobin and Tebuconazole compound indoor biological activity (virulence) mensuration of suspending agent.
1, experiment purpose
It is intended to measure pyraclostrobin, Tebuconazole and the two different proportion proportioning virulence to head blight, both judging
Whether different ratio has potentiation to suppression head blight.
2, experimental condition
2.1 for examination target
Gibberellic hypha, by Hefei City's water baseization biological material Engineering Technical Research Centre separation, purification, preserves and carries
Supply.
2.2 condition of culture
Cultivate in bio-incubator, temperature 25 ± 1 DEG C, relative humidity 85-95%.
2.3 instrument and equipment
Electronic balance (sensibility reciprocal 0.1mg), bio-incubator, diameter 9cm culture dish, pipet/rifle, inoculator, card punch,
Slide calliper rule etc..
3, EXPERIMENTAL DESIGN
3.1 examination materials prepare
Gibberellic hypha pathogen is placed in biochemical cultivation case cultivation, standby.
3.2 medicament
The former medicine of pyraclostrobin, Anhui Meilan Agricultural Development Co., Ltd. provides.
Original Tebuconazole, Anhui Meilan Agricultural Development Co., Ltd. provides.
3.3 medicament preparations
Medicament embodiment 1-6 prepared with acetone is diluted to 5 series mass concentration.
4, test method
Carry out with reference to " farm-chemical indoor determination test rule----antibacterial " (NY/T1156.6 2006).In order to touch
The rope each medicament activity to strains tested, first carries out preliminary experiment.Will be placed on containing higher and low concentration by mycelia
Cultivate under the culture medium of medicament, estimate EC50, then further according to the EC of estimation50Value, is made into its EC by culture medium50Left and right
The pastille culture medium of variable concentrations gradient cultivate.
This test uses plate mycelial growth rate method to measure the medicament virulence to gibberellic hypha.Concrete grammar is as follows: warp
The gibberellic hypha bacterial strain PSA culture medium culturing of switching activation, when bacterium colony length to culture dish 3/4ths size, with internal diameter be
The card punch of 5mm punches from edge, and the mycelia block broken into is as inoculum.Respectively medicament mother solution is added the PSA that people's sterilizing is melted
In culture medium, fully shake up, make medicament ultimate density (calculating by effective ingredient) reach variable concentrations gradient.15mL poured into by every ware
Left and right pastille culture medium, if not dosing is comparison, often processes 4 repetitions.The mycelia block (diameter 5mm) that transposing newly grows is in flat board
Central authorities, cultivate 2d (gibberellic hypha), 7d (gibberellic hypha) and 15d (gibberellic hypha) in being placed on 25 DEG C of incubators.Use decussation
Method measures colony diameter, calculates each process net growth, mycelial growth inhibition rate.
In formula: a diameter of 5mm of bacterium dish.
5, data statistic analysis
Mycelial growth inhibition rate is converted into probit value (y), and drug concentration (μ g/mL) is converted into logarithm value (x), with minimum
Square law tries to achieve virulence regression equation (y=a+bx).With DPS statistical software to each single dose and the log concentration value of different mixture and
Corresponding suppression ratio probit value carries out regression analysis, calculates EC50Value and 95% confidence limit.
According to EC50Calculate the actual measurement toxicity index (ATI) of built agent, theoretical toxicity index (TTI) and co-toxicity coefficient
(CTC)。
Built agent actual measurement toxicity index (ATI)=single dose EC50/ built agent EC50×100。
Built agent theory toxicity index (TTI)=A toxicity index × A is content (%)+B toxicity index × B in built agent
Content (%) in built agent.
Co-toxicity coefficient (CTC)=ATI/TTI × 100.
Calculating medicament different ratio synergy ratio (CTC) according to the abundant method of Sun Yun, CTC≤80 are antagonism, 80 ＜
CTC ＜ 120 is summation action, and CTC >=120 are potentiation.
6, result and analysis
The suspending agent of embodiment 1 and 6 preparation shows as notable synergistic effect to the co-toxicity of head blight, and (co-toxicity coefficient divides
Do not reach 180,185), and suspending agent prepared by embodiment 2-5 is showed only as summation action (poison altogether to the co-toxicity of head blight
Coefficient is followed successively by 85,83,87,90).Meanwhile, by the experiment of embodiment 6 it can be seen that with the addition of few in compounding suspending agent
After the daucosterol of amount, the compounding synergy of pyraclostrobin and Tebuconazole can be made to promote further.
Claims (2)
1. a pyraclostrobin and Tebuconazole compound suspending agent, it is characterised in that: at least it is made up of the component of following weight portion:
2. prepare pyraclostrobin as claimed in claim 1 and method that Tebuconazole compounds suspending agent for one kind, it is characterised in that: will
Through grinding at the beginning of colloid mill after raw material suction preparation still mix and blend, then through sand mill fine grinding, sample analysis, qualified rear filtration, meter
Measure, pack, put in storage.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106508950A (en) * | 2016-11-04 | 2017-03-22 | 淄博市农业科学研究院 | Compound seed coating agent containing pyraclostrobin, tebuconazole and dinotefuran, and application thereof |
| GB2612369A (en) * | 2021-11-02 | 2023-05-03 | Rotam Agrochem Int Co Ltd | Aqueous suspension antimicrobial composition |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172241A (en) * | 2011-03-19 | 2011-09-07 | 陕西汤普森生物科技有限公司 | Pesticide composition containing pyraclostrobin and triazoles |
| CN103404523A (en) * | 2013-08-21 | 2013-11-27 | 陕西康禾立丰生物科技药业有限公司 | Pesticide for preventing crop diseases such as powdery mildews, leaf spots and downy mildews and preparation thereof |
| CN103548857A (en) * | 2013-08-21 | 2014-02-05 | 陕西康禾立丰生物科技药业有限公司 | Pyraclostrobin-containing pesticide composition |
| CN103563944A (en) * | 2012-08-05 | 2014-02-12 | 南京华洲药业有限公司 | Bactericidal composition containing pyraclostrobin and tebuconazole and application thereof |
| WO2015062358A1 (en) * | 2013-10-30 | 2015-05-07 | Rotam Agrochem International Company Limited | Method of increasing yield by treating with fungicidal compositions |
| CN105265458A (en) * | 2014-07-18 | 2016-01-27 | 青岛瀚生生物科技股份有限公司 | Pyraclostrobin and tebuconazole compounded microcapsule suspending agent and preparation method thereof |
-
2016
- 2016-08-25 CN CN201610723692.1A patent/CN106070276A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172241A (en) * | 2011-03-19 | 2011-09-07 | 陕西汤普森生物科技有限公司 | Pesticide composition containing pyraclostrobin and triazoles |
| CN103563944A (en) * | 2012-08-05 | 2014-02-12 | 南京华洲药业有限公司 | Bactericidal composition containing pyraclostrobin and tebuconazole and application thereof |
| CN103404523A (en) * | 2013-08-21 | 2013-11-27 | 陕西康禾立丰生物科技药业有限公司 | Pesticide for preventing crop diseases such as powdery mildews, leaf spots and downy mildews and preparation thereof |
| CN103548857A (en) * | 2013-08-21 | 2014-02-05 | 陕西康禾立丰生物科技药业有限公司 | Pyraclostrobin-containing pesticide composition |
| WO2015062358A1 (en) * | 2013-10-30 | 2015-05-07 | Rotam Agrochem International Company Limited | Method of increasing yield by treating with fungicidal compositions |
| CN105265458A (en) * | 2014-07-18 | 2016-01-27 | 青岛瀚生生物科技股份有限公司 | Pyraclostrobin and tebuconazole compounded microcapsule suspending agent and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106508950A (en) * | 2016-11-04 | 2017-03-22 | 淄博市农业科学研究院 | Compound seed coating agent containing pyraclostrobin, tebuconazole and dinotefuran, and application thereof |
| GB2612369A (en) * | 2021-11-02 | 2023-05-03 | Rotam Agrochem Int Co Ltd | Aqueous suspension antimicrobial composition |
| CN116746584A (en) * | 2022-12-16 | 2023-09-15 | 江苏生久农化有限公司 | Comprehensive control composition for brown spot, sclerotium disease of mulberry and corn rust disease of flowers and preparation method thereof |
| CN116267977A (en) * | 2023-03-23 | 2023-06-23 | 江苏徐淮地区淮阴农业科学研究所 | A kind of pesticide composition for preventing and treating Gorgon leaf tumor and its application |
| CN116267977B (en) * | 2023-03-23 | 2025-01-14 | 江苏徐淮地区淮阴农业科学研究所 | A pesticide composition for preventing and treating Euryale ferox leaf gall disease and its application |
| CN116616304A (en) * | 2023-05-04 | 2023-08-22 | 江苏东南植保有限公司 | Azolyl ether and tebuconazole suspending agent and preparation method thereof |
| CN116491518A (en) * | 2023-05-09 | 2023-07-28 | 济南一农化工有限公司 | A suspension containing pyraclostrobin and its preparation process and application |
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Application publication date: 20161109 |