CN105994317A - Agricultural sterilizing composition containing isotianil and thifluzamide - Google Patents
Agricultural sterilizing composition containing isotianil and thifluzamide Download PDFInfo
- Publication number
- CN105994317A CN105994317A CN201610600366.1A CN201610600366A CN105994317A CN 105994317 A CN105994317 A CN 105994317A CN 201610600366 A CN201610600366 A CN 201610600366A CN 105994317 A CN105994317 A CN 105994317A
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- CN
- China
- Prior art keywords
- thifluzamide
- agriculture
- isotianil
- bactericidal composition
- agricultural
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- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 title claims abstract description 47
- 230000001954 sterilising effect Effects 0.000 title abstract description 6
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- 238000011321 prophylaxis Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 235000019355 sepiolite Nutrition 0.000 description 1
- 229910052624 sepiolite Inorganic materials 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- IZPNTDOWOBGHEG-UHFFFAOYSA-M sodium benzene formate Chemical compound [Na+].[O-]C=O.C1=CC=CC=C1 IZPNTDOWOBGHEG-UHFFFAOYSA-M 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000003516 soil conditioner Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 238000009333 weeding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to an agricultural sterilizing composition. The agricultural sterilizing composition contains isotianil and thifluzamide, wherein a weight ratio of isotianil to thifluzamide is 1: 10 to 10:1 and preferably 2:1 to 1:3. The agricultural sterilizing composition has an obvious synergistic effect of preventing and treating the rice sheath blight disease, prolongs lasting time, improves a sterilizing effect and is beneficial for overcoming and delaying generation of germ drug resistance.
Description
[technical field]
The invention belongs to technical field of pesticide.More particularly it relates to an containing different thiophene bacterium
Amine and the agricultural bactericidal composition of thifluzamide, and described agricultural bactericidal composition is in preventing and treating Oryza sativa L.
Application in banded sclerotial blight.
[background technology]
Rice sheath blight disease (Rhizoctonia solani) is the Major Diseases in Ge Dao producing region, the world, is Oryza sativa L.
The big obstacle of the one of stable high yield, also known as moire disease, popular name spends sufficient stalk, rotten foot pestilence, features speckle.Should
Disease is by fungus-caused, and pathogen is Basidiomycotina fungus thanatephorus cucumeris(frank) donk (Thanatephorus
cucumeris).Banded sclerotial blight is many to be occurred under high temperature, super-humid conditions, is in current Rice Production
One of Major Diseases.After morbidity, rice leaf is withered, and setting percentage declines, and mass of 1000 kernel alleviates, hollow kernels
Increase, general underproduction 10-30%, time serious, reach more than 50%.
Isotianil (isotianil), CAS accession number [224049-04-1], belong to isothiazole formamide
Compounds, has strong plant induced activity in plant, but does not produce pathogen directly
Antibacterial action, but by the natural immunology defense exciting crop self reach resist disease mesh
, also there is certain insecticidal activity, preventative use or in morbidity early application, multiple life
The thing factor and abiotic component can the defensive Resistant reaction i.e. system induction of activated plant self resist
Property, make plant that multiple fungus, antibacterial, insecticide and virus are produced the self-protection effect of wide spectrum.
And isotianil is provided that extended residual drug effect and the less dosage using effective ingredient, it is suitable for
Cause plant defense not by phytopathogenic fungi, antibacterial and virus and the infringement of insecticide, it is possible to use
Carry out regular period interior protection plant after treatment not encroached on by above-mentioned harmful organisms.
Thifluzamide (furametpyr), CAS accession number [123572-88-3], is pyrazol acid amide
Antibacterial.The Oxidation of the succinic acid in its suppression fungal mitochondria, thus avoid miliary damping-off
Mycelium separates, and to fungal mitochondria nicotinamide adenine dinucleotide reduced (NADH)
Oxidation without impact, its have excellence prophylactic treatment effect, the great majority to Basidiomycetes
Pathogenic bacteria thin,tough silk disease etc. has specially good effect.But use as single dose and prevent and treat rice sheath blight disease and be easily generated resistance, shadow
Ring prevention effect.
It is used alone prevents and treats that rice sheath blight disease consumption is big, be easily generated resistance to solve thifluzamide
Problem, the present inventor have developed the bactericidal composition that isotianil is compounding with thifluzamide, is used for preventing
Harness the river the various crop diseases such as the sheath and culm blight of rice.
[summary of the invention]
[solving the technical problem that]
It is an object of the invention to provide a kind of agricultural bactericidal group containing isotianil Yu thifluzamide
Compound.
Another object of the present invention provides described agricultural bactericidal composition preventing and treating rice sheath blight disease
In application.
[technical scheme]
The present invention is achieved through the following technical solutions.
The present invention relates to a kind of agricultural bactericidal composition, described agricultural bactericidal composition contains different thiophene bacterium
Amine and thifluzamide, wherein isotianil is 1:10～10:1 with the weight ratio of thifluzamide.
A preferred embodiment of the invention, isotianil with the weight ratio of thifluzamide is
2:1～1:3.
The present invention relates to a kind of disinfectant use in agriculture, described disinfectant use in agriculture contains 0.5～90 weight %
Described agricultural bactericidal composition, surplus is acceptable carrier and auxiliary agent on pesticide.
A preferred embodiment of the invention, described disinfectant use in agriculture contains 2～80 weight %
Described agricultural bactericidal composition, surplus is acceptable carrier and auxiliary agent on pesticide.
A preferred embodiment of the invention, described disinfectant use in agriculture contains 10～70 weights
The described bactericidal composition of amount %, surplus is acceptable carrier and auxiliary agent on pesticide.
According to a kind of detailed description of the invention of the present invention, the dosage form of described disinfectant use in agriculture is water-dispersible
Granule, suspending agent, wettable powder, microemulsion or aqueous emulsion.
The invention still further relates to described agricultural bactericidal composition or described disinfectant use in agriculture in preventing and treating Oryza sativa L.
Application in banded sclerotial blight.
The present invention will be described in detail belows.
The present invention relates to a kind of agricultural bactericidal composition, described agricultural bactericidal composition contains different thiophene bacterium
Amine and thifluzamide, wherein isotianil is 1:10～10:1 with the weight ratio of thifluzamide.
In the agricultural bactericidal composition of the present invention, when the amount of thifluzamide is in the range of described, as
Really the amount of isotianil exceedes the scope of described amount, then can be high because of consumption, and safety declines, Yi Fa
Crude drug evil.
When the amount of isotianil is in described scope, if the amount of thifluzamide exceedes described amount
Scope, also can be high because of consumption, and safety declines, and poisoning easily occurs.
Therefore, in the agricultural bactericidal composition of the present invention, isotianil and the weight of thifluzamide
Ratio is rational for 1:10～10:1.
Preferably, isotianil is 2:1～1:3 with the weight ratio of thifluzamide.
The present invention relates to a kind of disinfectant use in agriculture.Described disinfectant use in agriculture contains by weight
Agricultural bactericidal composition and surplus described in 0.5～90% are acceptable carrier and auxiliary agent on pesticide.
Except as otherwise noted, " % " involved in the present invention is " percentage by weight ".
In the present invention, described carrier or auxiliary agent are it should be understood that in Pesticide formulation or use
In be used for improving medicament physicochemical property, improve drug effect, it is simple to the complementary thing of the performances such as transport storage
Matter, such as wetting agent, emulsifying agent, dispersant, sticker, stabilizer or synergist etc..According to
The present invention, every have these performances and the disinfectant use in agriculture to the present invention does not has any negative effect
Chemical substance may be used to the present invention, they are all within protection scope of the present invention.
According to the present invention, if the agricultural bactericidal composition content of described disinfectant use in agriculture is less than 0.5%
Time, then can be low because of effective ingredient, the manufacturing of product it is unfavorable for from economic angle；If institute
When stating the agricultural bactericidal composition content of disinfectant use in agriculture higher than 90%, then can be the highest unfavorable because of content
In the performance of drug effect and be easily generated poisoning；Therefore, the agricultural bactericidal composition of described disinfectant use in agriculture
Content is 0.5～90% to be appropriate.
Preferably, described disinfectant use in agriculture contains agricultural bactericidal group described in 2～80% by weight
Compound, the agricultural bactericidal composition described in more preferably 10～70%, and surplus are can to connect on pesticide
The carrier being subject to and auxiliary agent.
According to the present invention, on pesticide, acceptable auxiliary agent is that one or more are selected from emulsifying agent, profit
Humectant, dispersant, thickening agent, antifreezing agent, disintegrating agent, binding agent, defoamer or filler
Auxiliary agent.These auxiliary agents are conducive to stable effective ingredients, and give full play to its drug effect.
According to method known in those skilled in the art, agricultural bactericidal composition of the present invention
The dosage form agriculturally allowed can be configured to when reality is applied, preferable dosage form be water dispersible granules,
Suspending agent, wettable powder, microemulsion or aqueous emulsion.
For water dispersible granules, those skilled in the art are very familiar with using corresponding auxiliary agent to complete
The present invention.Dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate；Moistening
Agent is selected from polyoxyethylene alcohol, alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Disintegrating agent is selected from
Ammonium sulfate, carbamide, sucrose, glucose, aluminum chloride, citric acid, succinic acid, sodium bicarbonate；
Binding agent is fine selected from kieselguhr, corn starch, PVA, carboxymethyl (ethyl) cellulose and crystallite
Dimension element class；Filler selected from kieselguhr, Kaolin, white carbon, fine particle calcium carbonate, meerschaum, Pulvis Talci,
Attapulgite, potter's clay etc..
For suspending agent, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignin sulfonic acid
Salt, alkylnaphthalene sulfonate, TERSPERSE 2425 (Huntsman Corporation of U.S. product, alkylnaphthalene
Sulfonates)；Emulsifying agent is selected from Nongru-700 # (common name: alkylphenol-formaldehyde resin polyoxyethylene
Ether), agriculture breast 2201, this dish-60# (common name: sorbitan monostearate), emulsifying agent T-60
(common name: sorbitan monostearate polyoxyethylene ether), agriculture breast 1601# (common name:
Phenethyl phenol polyoxyethylene poly-oxygen propylene aether), TERSPERSE 4894 (Huntsman Corporation of the U.S.
Produce), FS3000 (phosphate type anion surfactant)；Wetting agent is selected from alkyl phenol polyoxy
Ethylene poly-base ether formaldehyde condensation products sulfate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol
Polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE
2500 (Huntsman Corporation of U.S. products), SXC (sulfonic acid type anion surfactant)；Thickening
Agent is selected from xanthan gum, polyvinyl alcohol, aluminium-magnesium silicate, bentonite；Preservative is selected from benzoic acid, benzene
Sodium formate, BIT (1,2-benzisothiazole-3-ketone)；Defoamer is silicone defoamer；Anti-
Freeze agent selected from ethylene glycol, propylene glycol, glycerol, carbamide.
For wettable powder, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignin
Sulfonate, alkylnaphthalene sulfonate；Wetting agent is selected from alkyl sulfate, alkylsulfonate, LOMAR PWA EINECS 246-676-2
Salt；Filler selected from ammonium sulfate, carbamide, sucrose, glucose, kieselguhr, Kaolin, white carbon,
Fine particle calcium carbonate, Pulvis Talci, attapulgite, potter's clay etc..
For microemulsion, spendable auxiliary agent has: emulsifying agent is selected from calcium dodecyl benzene sulfonate (agriculture
Breast 500#), Nongru-700 #, agriculture breast 2201#, this dish-60#, tween 80-60#, TX-10,
Agriculture breast 1601, agriculture breast 600#, agriculture breast 400#；Cosolvent selected from methanol, isopropanol, n-butyl alcohol,
Ethanol；Solvent is selected from Ketohexamethylene, N-Methyl pyrrolidone, dimethylbenzene, toluene, solvent naphtha (board
Number: S-150, S-180, S-200)；Stabilizer is selected from triphenyl phosphite, epoxychloropropane.
For aqueous emulsion, spendable auxiliary agent has: emulsifying agent is selected from NPE
(EO=10) phosphate ester, triphenoethyl benzene phenol polyethenoxy ether phosphate (agriculture breast 600# phosphate ester),
Nongru-700 #, agriculture breast 2201#, Span-60#, emulsifying agent T-60, TX-10, agriculture breast 1601#,
Agriculture breast 600#, agriculture breast 400#；Solvent is selected from dimethylbenzene, toluene, Ketohexamethylene, solvent naphtha (board
Number: S-150, S-180, S-200)；Stabilizer selected from triphenyl phosphite, epoxychloropropane,
Acetic anhydride；Antifreezing agent is selected from ethylene glycol, propylene glycol, glycerol, carbamide, inorganic salts such as sodium chloride；
Thickening agent is selected from xanthan gum, polyvinyl alcohol, bentonite, aluminium-magnesium silicate；Preservative selected from benzoic acid,
Sodium benzoate.
Agricultural bactericidal composition of the present invention can provide with finished product preparation form, i.e. compositions
In each material the most blended；Can also provide with unit dose preparation, before using in bucket (tank) directly
Mixing.The concentrate of the present invention is generally and water is mixed to get the concentration of required active substance.
The invention still further relates to described agricultural bactericidal composition or described disinfectant use in agriculture in preventing and treating Oryza sativa L.
Purposes in banded sclerotial blight.
Agricultural bactericidal composition of the present invention and disinfectant use in agriculture can use conventional method to use, such as
Injection, spraying.Its amount of application can change according to weather conditions or crop growthing state, permissible
Used before or after disease occurs.The persistent period of protective effect is the most single with compositions
The content of compound is relevant, also relevant to extraneous factor, such as weather, but suitable by using
Dosage form can slow down the impact of weather.
Agricultural bactericidal composition of the present invention and disinfectant use in agriculture can also have weeding, sterilization with other
The compound of performance is used in mixed way, it is also possible to nematicide, protective agent, growth regulator, plant
Thing nutrient or soil conditioner are used in mixed way.
[beneficial effect]
Compared with prior art, agricultural bactericidal composition of the present invention has a following beneficial effect:
1, after isotianil and thifluzamide mixture, improve bactericidal effect, reduce use agent
Amount；
2, after isotianil and thifluzamide mixture, expanding fungicidal spectrum, medicament characteristic obtains
Having complementary advantages, a kind of medicament can prevent and treat various crop disease, facilitates peasant's medication；
3, after isotianil and thifluzamide mixture, because in compositions, the antibacterial mechanism of action is not
With, can effectively delay the drug-fast generation of pathogen, resistance and comprehensive control to disease have weight
Want meaning.
[detailed description of the invention]
In order to be more fully understood that the present invention, in conjunction with the following examples, the present invention is done furtherly
Bright, but it is not limited to embodiment.
In the present invention, if no special instructions, " % " is all weight percentage, ": " or " ratio "
It is weight ratio.
One, the preparation of disinfectant use in agriculture of the present invention
1, water dispersible granules is prepared
Embodiment 1: prepare 30% isotianil thifluzamide water dispersible granule (effective ingredient 1:3)
Weigh 7.5% isotianil, 22.5% thiophene in terms of this disinfectant use in agriculture water dispersible granules gross weight
Ofurace, 2% naphtholsulfonic acid formaldehyde condensation products, 1%N-methyl-oleoyl-sodium taurocholate, 1% can
Soluble starch and the Kaolin being supplemented to 100%.By formula proportion, by former medicine and auxiliary agent, filler
Deng mix homogeneously, after comminution by gas stream, obtain powder, add the mixing of a certain amount of water, at comminutor
In carry out pelletize, be then dried, sieve and i.e. obtain granular product.
Embodiment 2: prepare 22% isotianil thifluzamide water dispersion granule (effective ingredient
1:10)
Weigh 2% isotianil, 20% thiophene in terms of this disinfectant use in agriculture water dispersion granule gross weight
Ofurace, 3% naphtholsulfonic acid formaldehyde condensation products, 5% calcium lignosulfonate, 2% Nekal BX (two
Sodium butylnaphthalenesulfonate), 1%K-12 (sodium lauryl sulphate), 10% ammonium sulfate, starch adds to
100%.By formula proportion, by former medicine and the mix homogeneously such as auxiliary agent, filler, after comminution by gas stream
To powder, add the mixing of a certain amount of water, comminutor carries out pelletize, be then dried, sieve
Obtain granular product.
2, suspending agent is prepared
Embodiment 3: prepare 30% isotianil thifluzamide suspending agent (effective ingredient 1:1)
Weigh in terms of this disinfectant use in agriculture suspending agent gross weight 15% isotianil, 15% thifluzamide,
3%TERSPERSE 4894,3.5%SXC (sulfonic acid type anion surfactant), 0.1% Huang
Virgin rubber, 1% aluminium-magnesium silicate, 5% ethylene glycol, 0.03%BIT (1,2-benzisothiazole-3-ketone),
0.5% organic silicon defoamer TA32H (Evonik Degussa Corp.'s product), deionized water adds to 100%.
By formula proportion, with water as medium, former medicine, dispersant, suspending agent and antifreezing agent etc. are joined
High-shear emulsion machine is sheared 30min, then with after sand mill sand milling, obtains suspending agent.
Embodiment 4: prepare 30% isotianil thifluzamide suspending agent (effective ingredient 5:1)
Weigh in terms of this disinfectant use in agriculture suspending agent gross weight 25% isotianil, 5% thifluzamide,
3%FS3000 (phosphate type anion surfactant), 1.5%SXC (sulfonic acid type anion
Surfactant), 0.25% xanthan gum, 0.5% aluminium-magnesium silicate, 5% ethylene glycol, 0.03%BIT (1,2-
Benzisothiazole-3-ketone), 0.3% organic silicon defoamer TA32H (Evonik Degussa Corp.'s product),
Deionized water adds to 100%.By formula proportion, with water as medium, by former medicine, dispersant, help
Suspension and antifreezing agent etc. join in high-shear emulsion machine shearing 30min, then with after sand mill sand milling,
Obtain suspending agent.
3, wettable powder is prepared
Embodiment 5: prepare 30% isotianil thifluzamide wettable powder (effective ingredient 1:2)
Weigh 10% isotianil, 20% thiophene furan in terms of this disinfectant use in agriculture wettable powder gross weight
Amide, 5%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX, 1%K-12,
5% white carbon, Kaolin add to 100%.By recipe requirements, by various auxiliary agents, filler, former medicine
After mixing after Roughpulverizer is pulverized, enter jet mill and be fully pulverized and mixed prepared wettable powder
Agent.
Embodiment 6: prepare 30% isotianil thifluzamide wettable powder (effective ingredient 2:1)
Weigh 20% isotianil, 10% thiophene furan in terms of this disinfectant use in agriculture wettable powder gross weight
Amide, 2% sodium lauryl sulphate, 5% naphthalene sulfonic acid-formaldehyde condensation product, 4% sodium lignin sulfonate,
6% White Carbon black and the precipitated calcium carbonate being supplemented to 100%.By recipe requirements, by various auxiliary agents, fill out
After the mixing of material, former medicine after Roughpulverizer is pulverized, enter jet mill and be fully pulverized and mixed prepared
Wettable powder.
4, microemulsion is prepared
Embodiment 7: prepare 11% isotianil thifluzamide microemulsion (effective ingredient 10:1)
Weigh in terms of this disinfectant use in agriculture microemulsion gross weight 10% isotianil, 1% thifluzamide,
2% Nongru-700 #, 2% agriculture breast 500#, 2% agriculture breast 1601#, 15% cyclohexanone, 5%N-methyl
Ketopyrrolidine, through dissolving completely and mix homogeneously, deionized water adds to 100%, after stirring,
Obtain product.
Embodiment 8: prepare 16% isotianil thifluzamide microemulsion (effective ingredient 3:1)
Weigh in terms of this disinfectant use in agriculture microemulsion gross weight 12% isotianil, 4% thifluzamide,
4% Nongru-700 #, 3% agriculture breast 500#, 5% this dish-60#, 20% toluene, 10%N-methylpyrrole
Alkanone, through dissolving completely and mix homogeneously, deionized water adds to 100%, after stirring,
To product.
5, aqueous emulsion is prepared
Embodiment 9: prepare 30% isotianil thifluzamide aqueous emulsion (effective ingredient 1:5)
Weigh in terms of this disinfectant use in agriculture aqueous emulsion gross weight 5% isotianil, 25% thifluzamide,
5% agriculture breast 2201#, 4% NPE (EO=10) phosphate ester, 3% agriculture breast 600#,
1% epoxychloropropane, 20% dimethylbenzene, 15% Ketohexamethylene, mixed dissolution obtains oil phase.5% second two
Alcohol, 0.1% xanthan gum, 0.03%BIT (1,2-benzisothiazole-3-ketone), deionized water add to
100%, it is made into aqueous phase.Oil phase addition aqueous phase is sufficiently mixed, after high-shear emulsifying, is produced
Product.
Embodiment 10: prepare 35% isotianil thifluzamide aqueous emulsion (effective ingredient 2:5)
Weigh in terms of this disinfectant use in agriculture aqueous emulsion gross weight 10% isotianil, 25% thifluzamide,
3% agriculture breast 1601,3% NPE (EO=10) phosphate ester, 2.5% agriculture breast 600#,
2.5%Span-60#, 1.5% epoxychloropropane, 20% dimethylbenzene, 20% Ketohexamethylene, mixed dissolution
Obtain oil phase.5% ethylene glycol, 0.1% xanthan gum, 0.03%BIT (1,2-benzisothiazole-3-
Ketone), deionized water add to 100%, be made into aqueous phase.Oil phase addition aqueous phase is sufficiently mixed, through height
After emulsification pretreatment, obtain product.
6, granule is prepared
Embodiment 11: prepare 8% isotianil thifluzamide granule (effective ingredient 1:7)
Weigh in terms of this disinfectant use in agriculture granule gross weight 1% isotianil, 7% thiophene methuroxam,
2% naphtholsulfonic acid formaldehyde condensation products, 1%N-methyl-oleoyl-sodium taurocholate, 0.5% aluminum chloride,
1% xanthan gum and the Kaolin being supplemented to 100%.By formula proportion, by former medicine and auxiliary agent, filler
Deng mix homogeneously, after comminution by gas stream, obtain powder, add the mixing of a certain amount of water, at comminutor
In carry out pelletize, be then dried, sieve and i.e. obtain granular product.
Embodiment 12: prepare 10% isotianil thifluzamide granule (effective ingredient 1:4)
Weigh in terms of this disinfectant use in agriculture granule gross weight 2% isotianil, 8% thiophene methuroxam,
3% naphtholsulfonic acid formaldehyde condensation products, 4%N-methyl-oleoyl-sodium taurocholate, 1% aluminum chloride, 2%
Xanthan gum and the Kaolin being supplemented to 100%.By formula proportion, by former medicine and auxiliary agent, filler etc.
Mix homogeneously, obtains powder after comminution by gas stream, adds the mixing of a certain amount of water, in comminutor
Carry out pelletize, be then dried, sieve and i.e. obtain granular product.
Two, BIOLOGICAL ACTIVITY EXAMPLES
BIOLOGICAL ACTIVITY EXAMPLES is divided into indoor biological activity Example and land for growing field crops BIOLOGICAL ACTIVITY EXAMPLES.
Activity Example 1: isotianil and thifluzamide are malicious to the indoor of rice sheath blight disease after compounding
Power measures
In order to further appreciate that isotianil and the virulence of thifluzamide complex composition, carry out big
Amount formulation screening test.
Agricultural bactericidal composition biological activity determination of the present invention is as follows:
According to bactericide agricultural chemicals indoor bioassay test rule (agricultural industry criteria
NY/T1156.8-2007), single dose EC is measured50With mixture EC50。
The Toxicity Determination of rice sheath blight disease is tested employing pot-culture method.Select two leaves one
The potted plant rice seedling that the heart, growing way are consistent, dries after spraying treatment naturally, and about 24h inoculates,
Be jetted through every basin rice seedling base portion central authorities one piece of damping-off mycelia block of clamping connection of medicine, truffle not with basin
Soil and water layer contact.Postvaccinal examination material moves to cultivate in humidistat, temperature 25～26 DEG C, humidity
80～90%, observe rice growth situation every day, when after 5 days, blank is fully fallen ill, investigation is anti-
Control effect.
Investigation method and grade scale are as follows:
0 grade: whole strain is anosis；
1 grade: first sheath morbidity；
3 grades: first blade and the morbidity of the second sheath；
5 grades: second blade and the morbidity of the 3rd sheath；
7 grades: whole strain is fallen ill.
Calculate each with disease index and process prevention effect, with " DPS data handling system " V14.50
Professional version carries out data analysis statistical, obtains regression straight line, EC50Value, correlation coefficient.Use Sun Yun
Each EC processed that abundant method (Sun etc., 1960) will measure50Value is converted into actual toxicity index
(ATI)；Proportioning according to mixture, it is thus achieved that theoretical toxicity index, is calculated mixed by following formula
The co-toxicity coefficient (CTC) of agent:
Toxicity index × the A of theoretical mixed toxicity index (TTI)=A content (%) in mixed
Toxicity index × the B of+B content (%) in mixed
According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying, work as co-toxicity coefficient
(CTC), time more than 120, show that this mixture has potentiation；And co-toxicity coefficient (CTC)
During less than 80, show that this mixture has antagonism；And co-toxicity coefficient (CTC) is more than 80
During less than 120, show that this mixture has summation action.
Isotianil and the thifluzamide different ratio mixture Toxicity Determination to rice sheath blight disease
Result see table 1.
Table 1: isotianil and thifluzamide and different ratio are to rice sheath blight disease
Toxicity Determination result
From above-mentioned Toxicity Determination result it can be seen that isotianil and thifluzamide are in weight ratio
When compounding in the range of 1:10～10:1, its co-toxicity coefficient (CTC) is all higher than 120, different thiophene is described
Rice sheath blight disease is had significant synergies by bacterium amine with thifluzamide mixture.
2, activity Example 2: prevent and treat rice sheath blight disease field control effectiveness test
According to medicine inspecting institute of the Ministry of Agriculture " GB/T 17980.20-2000 pesticide field efficacy medicine test criterion ()
Bactericidal agent for preventing and treating rice sheath blight disease " regulation carry out test.Test medicine, comparison medicament and blank
The community of comparison processes and uses the level arrangement of random district, plot area 20m2, repeat for 4 times, this test
Amount to dispenser twice.It is in their early stage for the first time during dispenser, after two weeks, executes second time medicine.This examination
Testing investigation 2 times altogether, every experimental plot uses diagonal 5 sampling, every some investigation to be connected 5 clumps,
Totally 25 clumps, record disease grade.
Disease scale standard is as follows:
0 grade: Herb is anosis；
1 grade: quaterfoil and following sheath, blade morbidity (with sword-like leave for first leaf)；
3 grades: three leaf and following sheath, blade morbidity；
5 grades: second leaf and following sheath, blade morbidity；
7 grades: sword-like leave blade and following sheath, blade morbidity；
9 grades: Herb falls ill, the most withered.
Drug effect computational methods:
According to survey result, calculate disease index and preventive effect according to following (1), (2) formula.
In formula: CK0、CK1It is respectively the disease index that the dispenser of blank district is forward and backward；PT0、
PT1It is respectively the disease index that chemicals treatment district medicine is forward and backward.
Result of the test is listed in table 2 below.
Rice sheath blight disease field control effectiveness test result prevented and treated by table 2
It can be seen that effective ingredient consumption quite or basic quite on the premise of, the group of the present invention
Compound is all significantly better than isotianil or thiophene furan to 7 days preventive effects and 14 days preventive effects of rice sheath blight disease
Amide single dose, has significant cooperative synergism effect, therefore, it is possible to reduce times for spraying, lowers and uses
Medicine cost.
In sum, indoor biometrics and field control effectiveness test result show Bactericidal composite of the present invention
Thing has a following beneficial effect:
1, compared with single dose, this bactericidal composition has significant potentiation to make to preventing and treating rice sheath blight disease
With, extend the lasting period, improve bactericidal effect；
2, reduce times for spraying, lower drug cost, reduce environmental pollution and pesticide residues；
3, compositions is made up of the effective ingredient of different mechanism of action, and action site increases, favorably
In overcoming and delaying the drug-fast generation of pathogenic bacteria.Present composition nothing equal to trial crops is the most not
Good impact, leaf color, growing way etc. are all normal, and safety is good, meets the security requirement of pesticidal preparations.
Agricultural bactericidal composition of the present invention has good preventive effect to rice sheath blight disease.
Claims (7)
1. an agricultural bactericidal composition, it is characterised in that described agricultural bactericidal composition contains
Isotianil and thifluzamide, wherein isotianil with the weight ratio of thifluzamide is
1:10～10:1.
Agricultural bactericidal composition the most according to claim 1, it is characterised in that different thiophene bacterium
Amine is 2:1～1:3 with the weight ratio of thifluzamide.
3. a disinfectant use in agriculture, it is characterised in that described disinfectant use in agriculture contains 0.5～90 weights
The agricultural bactericidal composition described in claim 1 or 2 of amount %, surplus is acceptable on pesticide
Carrier and auxiliary agent.
Disinfectant use in agriculture the most according to claim 3, it is characterised in that described agricultural kill
Microbial inoculum contains the agricultural bactericidal composition described in claim 1 or 2 of 2～80 weight %, remaining
Amount is acceptable carrier and auxiliary agent on pesticide.
Disinfectant use in agriculture the most according to claim 3, it is characterised in that described agricultural kill
Microbial inoculum contains the bactericidal composition described in claim 1 or 2 of 10～70 weight %, and surplus is
Acceptable carrier and auxiliary agent on pesticide.
6., according to the disinfectant use in agriculture described in claim any one of claim 3-5, it is special
Levy and be that its dosage form is water dispersible granules, suspending agent, wettable powder, microemulsion or aqueous emulsion.
Agricultural bactericidal composition the most according to claim 1 and 2 or according to claim
Disinfectant use in agriculture described in claim any one of 3-7 answering in preventing and treating rice sheath blight disease
With.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108294026A (en) * | 2018-02-28 | 2018-07-20 | 佛山市海力盈生物科技有限公司 | A kind of composition pesticide containing Pyriofenone and thifluzamide |
| CN113243380A (en) * | 2021-05-31 | 2021-08-13 | 合肥巨卓农业技术开发有限公司 | Sterilization composition containing isotianil and Xinjunan acetate |
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