CN1059835C - Anticancer analgesic plaster and its preparing method - Google Patents
Anticancer analgesic plaster and its preparing method Download PDFInfo
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- CN1059835C CN1059835C CN97121729A CN97121729A CN1059835C CN 1059835 C CN1059835 C CN 1059835C CN 97121729 A CN97121729 A CN 97121729A CN 97121729 A CN97121729 A CN 97121729A CN 1059835 C CN1059835 C CN 1059835C
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- 239000003814 drug Substances 0.000 claims abstract description 24
- 239000002674 ointment Substances 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 8
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- 239000003053 toxin Substances 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 241000717739 Boswellia sacra Species 0.000 claims description 6
- 241000190633 Cordyceps Species 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 6
- 241000972155 Moschus Species 0.000 claims description 6
- 241001057584 Myrrha Species 0.000 claims description 6
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- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 claims description 6
- 238000007670 refining Methods 0.000 claims description 4
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- 241000233866 Fungi Species 0.000 abstract 1
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- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 241000239226 Scorpiones Species 0.000 abstract 1
- 241000270295 Serpentes Species 0.000 abstract 1
- 241000411851 herbal medicine Species 0.000 abstract 1
- HTUMBQDCCIXGCV-UHFFFAOYSA-N lead oxide Chemical compound [O-2].[Pb+2] HTUMBQDCCIXGCV-UHFFFAOYSA-N 0.000 abstract 1
- YEXPOXQUZXUXJW-UHFFFAOYSA-N lead(II) oxide Inorganic materials [Pb]=O YEXPOXQUZXUXJW-UHFFFAOYSA-N 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 9
- 201000011510 cancer Diseases 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
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- JMZOMFYRADAWOG-UHFFFAOYSA-N methyl 7-methoxy-4-(7-methoxy-5-methoxycarbonyl-1,3-benzodioxol-4-yl)-1,3-benzodioxole-5-carboxylate Chemical compound COC(=O)C1=CC(OC)=C2OCOC2=C1C1=C2OCOC2=C(OC)C=C1C(=O)OC JMZOMFYRADAWOG-UHFFFAOYSA-N 0.000 description 3
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- 108010082126 Alanine transaminase Proteins 0.000 description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention belongs to the technical field of a traditional Chinese medicine, which particularly relates to an anticancer analgesic ointment and a preparation method thereof. The anticancer analgesic ointment is prepared from the formula medicines: 90 to 100 scorpions, 90 to 100 centipedes, 250 to 300g of rhizoma arisaematis, 250 to 300g of common monkshood root, 250 to 300g of radix aconiti kusneziffii, 250 to 300g of safflower, 250 to 300g of angelica, 250 to 300g of chuanxiong rhizome, 250 to 300g of frankincense, 250 to 300g of myrrh, 30 to 50g of musk, 250 to 300g of snake slough, 250 to 300g of cicada slough, 50 to 100g of litharge, 250 to 300g of Chinese caterpillar fungus and 250 to 300g of red lead. The preparation method comprises the steps: the Chinese herbal medicines are cut and put into an oil bath to be decocted; after the medicines are decocted, dried red lead fine powder is added to the oil bath at 80 to 100 DEG C; then, the fire-toxin is eliminated; the heating operation and the melting operation are carried out, and the musk is added to prepare the ointment with an anticancer function and an analgesic function. The anticancer analgesic ointment has the advantages of no side effect and high effective rate for treating cancers.
Description
The invention belongs to technical field of Chinese medicines, particularly anticancer analgesic plaster.
At present, tumor is still sickness rate and the higher a kind of disease of mortality rate in the world, and in order to cure this kind persistent ailment, people are constantly medically exploring, in the hope of searching out a kind of good recipe that can treat tumor effectively.In recent years, no matter in doctor trained in Western medicine in the traditional Chinese medical science, though aspect the treatment cancer some gratifying progress are being arranged, but can't accomplish to cure the cancer patient of the overwhelming majority, especially to the treatment cancer patient in late period.For not operating on the patient who effects a radical cure cancer, how to cure their disease, alleviate their pain, today, the relevant person has had certain achievement in research in this respect, as the Chinese patent publication number is the treatment means that open source literatures such as CN1099295A, CN1151871A and 1130525A are reported, though all adopt the plaster form, be means with the external treatment cancer, they exist different defectives, it can only short-term alleviate patient's pain, and can not play the effect of treatment disease.
The object of the present invention is to provide a kind of nontoxic, have no side effect, the effective percentage height, can alleviate cancer patient's pain, can play the anticancer analgesic plaster of therapeutical effect again.
The object of the present invention is achieved like this: it is made up of following prescription drug
Scorpio 90-100 bar Scolopendra 90-100 bar Rhizoma Arisaematis 250-300g
Radix Aconiti 250-300g Radix Aconiti Kusnezoffii 250-300g Flos Carthami 250-300g
Radix Angelicae Sinensis 250-300g Rhizoma Chuanxiong 250-300g Olibanum 250-300g
Myrrha 250-300g Moschus 30-50g Periostracum Serpentis 250-300g
Periostracum Cicadae 250-300g Lithargyrum 50-100g Cordyceps 250-300g
Plumbum preparatium 250-300g
Olibanum 250-300g, Myrrha 250-300g, Cordyceps 250-300g are ground into fine powder, Scorpio 90-100 bar, Scolopendra 90-100g bar, Rhizoma Arisaematis 250-300g, Radix Aconiti 250-300g, Radix Aconiti Kusnezoffii 250-300g, Flos Carthami 250-300g, Radix Angelicae Sinensis 250-300g, Rhizoma Chuanxiong 250-300g, Periostracum Serpentis 250-300g, Periostracum Cicadae 250-300g, Lithargyrum 50-100g is cataclasm, pack in the wire mesh cage, send in the oil refining cauldron, then with 80-100 ℃ of heating extraction, until medicine caye endure withered, the outside of medical material be dark brown and inner sallow till (but must not carbonization blackening); After medicine has been endured, treat that temperature reaches under the 70-90 ℃ of situation, connects cage with medicinal residues and shifts out pot together, and oil precipitated gradually or filter clarification, refine oil, make oil oxidation under 80-100 ℃ of high temperature, polymerization, thickening, be degree to " dripping into pearl ", and then will fry the Plumbum preparatium fine powder 250-300g that does, slowly add in the oil cauldron, make red and the at high temperature abundant chemical combination of oil, when ointment tack-free, when denseness is suitable, medicine is carried out releasing fire-toxin according to a conventional method; With the temperature fusing a little again of half patent medicine behind the releasing fire-toxin, add Moschus 30-50g, stir, finally make ointment of the present invention.
The present invention has the function of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, can killing tumor cell, suppress growth of tumour cell, and again can the enhancing human body immunity function, the dissipation lump reaches the purpose of healing.Theory of Chinese medical science thinks that viscera and affiliated meridian point are closely related.So medicine of the present invention is made patch in relevant acupuncture point, make the property of medicine go into its space between skin and muscles from pore, stimulate the menstrual flow and pass through network, give full play to the property of medicine, can treat uterus carcinoma, laryngeal carcinoma, pulmonary carcinoma, hepatocarcinoma, gastric cancer, breast carcinoma, osteocarcinoma etc.Plaster of the present invention, every subsides curative effect can reach 3 days.
The present invention is through attached first hospital of specified Heilongjiang University of Chinese Medicine of Heilongjiang Province Department of Public Health, second hospital and Heilongjiang Province Academy of Traditional Chinese Medicine Pharmaceutical Manufacturing Plant's three tame hospital clinical researchs, confirm certain avirulence and side effect, clinical effectiveness to 300 routine cancer patients shows, anticancer analgesic plaster is evident in efficacy, effective percentage is more than 90%, patient is after using plaster of the present invention to paste a week, mental attitude is improved, diet increases, skin is by festering to smooth improvement, and taken place to sending the phenomenon that the slight state of an illness such as sound alleviate by aphonia.
Below by embodiment technical scheme of the present invention is further described: embodiment 1:
Olibanum 250g, Myrrha 250g, Cordyceps 250g are ground into fine powder, 90 of Scorpios, 90 of Scolopendras, Rhizoma Arisaematis 300g, Radix Aconiti 300g, Radix Aconiti Kusnezoffii 300g, Flos Carthami 250g, Radix Angelicae Sinensis 250g, Rhizoma Chuanxiong 250g, Periostracum Serpentis 250g, Periostracum Cicadae 250g, Lithargyrum 50g is cataclasm, pack in the wire mesh cage, send in the oil refining cauldron that fills 5 jin of Oleum Sesami, be heated to then about 100 ℃, until medicine caye endure withered, the outside of medical material be dark brown and inner sallow till; Cooling, when treating that temperature is 80 ℃ of left and right sides, medicinal residues are connected cage shift out pot together, and oil is filtered clarification, the oil refining of heating, oily temperature is reached about 100 ℃, till making oil " drip into pearl ", and then will fry the Plumbum preparatium 250g fine powder of doing and add slowly in the oil cauldron, make red and the at high temperature abundant chemical combination of oil, when ointment is tack-free, medicine is put into cool bubbly water last 12 hour of releasing fire-toxin; And then half patent medicine heated about 80 ℃, add Moschus 30g, stir, thereby make every obedient 5g, the anticancer analgesic ointment of about 400 cards.Embodiment 2:
Olibanum 300g, Myrrha 250g, Cordyceps 300g are ground into fine powder, 100 of Scorpios, Scolopendra 100g bar, Rhizoma Arisaematis 250g, Radix Aconiti 250g, Radix Aconiti Kusnezoffii 250g, Flos Carthami 300g, Radix Angelicae Sinensis 300g, Rhizoma Chuanxiong 250g, Periostracum Serpentis 300g, Periostracum Cicadae 250g, Lithargyrum 100g is cataclasm, method according to embodiment 1 is made, and adding Plumbum preparatium 300g, Moschus 50g, finally make every subsides 7g, about 300 anticancer analgesic plasters of the present invention that paste.Embodiment 3:
Get Kunming mouse, body weight 18-22g, male and female half and half.Test method and result: 1, to the protective effect of carbon tetrachloride acute liver damage
Mice only 50 is divided into 5 groups at random, 10 every group, anticancer analgesic plaster high dose group 0.3g/ of the present invention only, low dose group 0.1g/ only is affixed on position, abdominal part hepatic region, pastes 8 hours at every turn, pastes continuously 5 days; Sun is to medicine bifendate gastric infusion 0.2/kg, blank group and carbon tetrachloride model group all to etc. the capacity normal saline, except that the blank group is not given the carbon tetrachloride, all the other each groups all are administered once after 1% carbon tetrachloride oil solution 0.2ml/20g is annotated in 4 days abdominal cavities after the administration again, the socket of the eye vein is got blood after 10 hours, separation of serum is measured serum SGPT content, and result of the test sees Table 1
Group dosage SGPT P
High dose 0.3h/ only 20.76 ± 8.15＜0.05
*
Low dosage 0.1g/ only 21.12 ± 8.85＜0.05
*
Bifendate 0.7g/kg 17.81 ± 5.41＜0.05
*
Capacity such as carbon tetrachloride 30.56 ± 7.75＜0.01
Capacity 15.56 ± 4.55 such as blank group
*Relatively compare with the carbon tetrachloride group with the blank group
2, the influence that mouse writhing is reacted
Get 40 of mices, be divided into four groups at random, 10 every group, medication, dosage, time, behind last administration (the 5th time) medicine 1 hour, lumbar injection 0.6% acetic acid 0.2ml/ only all with test 1, observe to annotate respectively organize Mus behind the acetic acid in 15 minutes turn round the body number of times, result of the test sees Table 2.
The effect that table 2 anticancer analgesic plaster of the present invention reacts mouse writhing (X ± SD)
Group dosage is turned round only capacity 25.34 ± 16.55 embodiment 4 such as 10.74 ± 10.25＜0.05 low dosage 0.1g/ 12.70 ± 12.21＞0.05 bifendate 0.7g/kg, 14.40 ± 10.80＞0.05 blank group of body number of times P high dose 0.3g/ in 15 minutes:
Get plaster in embodiment 1 or 2 and be affixed on the Baihui acupoint and the throat of a. patients with laryngeal carcinoma, paste about a week, the patient can send slight sound by not pronouncing, and can normally speak in one month.B. spine's fei shu of patients with lung cancer and Ipsilateral chest, spine's fei shu bl of liver cancer patient and right flank (hepatic region); Palliate the agonizing sufferings about one week, January, tumor was dwindled, and 7～8 months is a course of treatment.C. spine's fei shu of patients with gastric cancer and gastral cavilty portion, pain relief after the week, appetite increases, and is clearly better in 3～4 months.D. patient with breast cancer's patient part, tumor obviously reduces about 3 months.E. osteocarcinoma patient's patient part eased the pain in 3～5 days, was clearly better in 7～8 months.F. uterus carcinoma patient's Yongquan acupoint (arch of the foot) stopped sanguinariness in 2～4 hours, and one month is a course of treatment, is clearly better in 3～4 months.G. skin carcinoma patient's disease sites took a turn for the better in one month, and it is smooth that skin becomes.H. the disease sites of intestinal cancer, Pancreas cancer patients, a week eases the pain, and is clearly better in 3～4 months; Can stop the intestinal cancer patient diarrhea of every day in 3～5 days.
Claims (1)
1. anticancer analgesic plaster is characterized in that it is made by following material medicine:
Scorpio 90-100 bar Scolopendra 90-100 bar Rhizoma Arisaematis 250-300g
Radix Aconiti 250-300g Radix Aconiti Kusnezoffii 250-300g Flos Carthami 250-300g
Radix Angelicae Sinensis 250-300g Rhizoma Chuanxiong 250-300g Olibanum 250-300g
Myrrha 250-300g Moschus 30-50g Periostracum Serpentis 250-300g
Periostracum Cicadae 250-300g Lithargyrum 50-100g Cordyceps 250-300g
Plumbum preparatium 250-300g
A. Olibanum 250-300g, Myrrha 250-300g, Cordyceps 250-300g are ground into fine powder, Scorpio 90-100 bar, Scolopendra 90-100g bar, Rhizoma Arisaematis 250-300g, Radix Aconiti 250-300g, Radix Aconiti Kusnezoffii 250-300g, Flos Carthami 250-300g, Radix Angelicae Sinensis 250-300g, Rhizoma Chuanxiong 250-300g, Periostracum Serpentis 250-300g, Periostracum Cicadae 250-300g, Lithargyrum 50-100g is cataclasm, pack in the wire mesh cage, send in the oil refining cauldron, then with 80-100 ℃ of heating extraction, until medicine caye endure withered, the outside of medical material be dark brown and inner sallow till;
B. after medicine has been endured, treat that temperature reaches under the 70-90 ℃ of situation, connects cage with medicinal residues and shifts out pot together, and oil precipitated gradually or filter clarification, refine oil, make oil oxidation under 80-100 ℃ of high temperature, polymerization, thickening, be degree to " dripping into pearl ", and then will fry the Plumbum preparatium fine powder 250-300g that does, slowly add in the oil cauldron, make red and the at high temperature abundant chemical combination of oil, when ointment tack-free, when denseness is suitable, medicine is carried out releasing fire-toxin according to a conventional method;
C. with the temperature fusing a little again of half patent medicine behind the releasing fire-toxin, add Moschus 30-50g, stir, finally make anticancer analgesic plaster.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97121729A CN1059835C (en) | 1997-12-16 | 1997-12-16 | Anticancer analgesic plaster and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97121729A CN1059835C (en) | 1997-12-16 | 1997-12-16 | Anticancer analgesic plaster and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1220149A CN1220149A (en) | 1999-06-23 |
| CN1059835C true CN1059835C (en) | 2000-12-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97121729A Expired - Fee Related CN1059835C (en) | 1997-12-16 | 1997-12-16 | Anticancer analgesic plaster and its preparing method |
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| Country | Link |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130088A (en) * | 1995-12-28 | 1996-09-04 | 安徽药都药业有限公司 | Pure traditional Chinese medicinal anti-cancer drug |
| CN1130525A (en) * | 1995-03-08 | 1996-09-11 | 刘培展 | Quick-acting ointment for removing dampness and relieving cancer |
-
1997
- 1997-12-16 CN CN97121729A patent/CN1059835C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130525A (en) * | 1995-03-08 | 1996-09-11 | 刘培展 | Quick-acting ointment for removing dampness and relieving cancer |
| CN1130088A (en) * | 1995-12-28 | 1996-09-04 | 安徽药都药业有限公司 | Pure traditional Chinese medicinal anti-cancer drug |
Non-Patent Citations (3)
| Title |
|---|
| 中医药学报1983(1) 1983.1.31 贝润浦，镇痛消肿膏治疗肿瘤临床观察 * |
| 江西中医药1993,24(2) 1993.2.28 李智，神效止痛膏治疗肝癌痛68例简报 * |
| 江西中医药1993,24(2) 1993.2.28 李智，神效止痛膏治疗肝癌痛68例简报;中医药学报1983(1) 1983.1.31 贝润浦，镇痛消肿膏治疗肿瘤临床观察 * |
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|---|---|
| CN1220149A (en) | 1999-06-23 |
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