CN101327313B - Oral medication for treating epigastric pain - Google Patents
Oral medication for treating epigastric pain Download PDFInfo
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- CN101327313B CN101327313B CN2008101504819A CN200810150481A CN101327313B CN 101327313 B CN101327313 B CN 101327313B CN 2008101504819 A CN2008101504819 A CN 2008101504819A CN 200810150481 A CN200810150481 A CN 200810150481A CN 101327313 B CN101327313 B CN 101327313B
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- 229940126701 oral medication Drugs 0.000 title claims description 5
- 206010000087 Abdominal pain upper Diseases 0.000 title abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 28
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 18
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- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 9
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 15
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an oral medicine for remedying stomachache. The medicine is made from the raw materials with the following portions of 5-12 portions of magnolia officinalis, 4-6 portions of tangerine peel, 4-6 portions of immature tangerine, 4-6 portions of cyperus rotundus l, 4-6 portions of citrus aurantium, 4-6 portions of Szechwan lovage rhizome, 4-6 portions of rhizoma corydalis, 4-6 portions of turmeric, 1-8 portions of cortex moutan, 4-6 portions of white peony root, 4-6 portions of amomum, 1-7 portions of angelica, 4-9 portions of evodia rutaecarpa, 1-8 portions of cardamom, 1-7 portions of clove, 1-7 portions of eaglewood, 1-7 portions of cinnamon, 4-6 portions of , 1-7 portions of rosa banksiae, 1-7 portions of poria cocos, 4-6 portions of sodium bicarbonate and 4-6 portions of prepared licorice. The clinic of the oral medicine is mainly used for remedying acute or chronic gastritis, gastric ulcer, chronic atrophic gastritis, dyspepsia, chronic hepatitis b and so on. The total effective rate for remedying chronic gastritis is 94.7 percent. The total effective rate for remedying gastric ulcer and chronic atrophic gastritis is 93.9 percent. The total effective rate for remedying dyspepsia is 96.1 percent, and at the same time, the oral medicine also has efficacy for remedying chronic hepatitis B.
Description
Technical field
The present invention relates to the pharmaceutical product technical field, particularly a kind of pure Chinese medicinal preparation for the treatment of gastroenteropathy.
Background technology
In the growing current society of economy, many youngsters are along with the increase of operating pressure and the quickening of rhythm of life, and traditional meal time is upset, and forget breakfast, postpone lunch, dinner is rich, diet does not have rule, causes increasing people pathological changes such as stomachache, hypochondriac pain to occur.At present, though the like product of a large amount of these type of diseases of treatment is arranged on the market, because Western medicine has side effect and zest to be unfavorable for this type of treatment of conditions.Therefore, traditional Chinese medicine preparation has occupied the advantage that gets richly endowed by nature on this type of treatment of diseases.
Summary of the invention
The oral drugs of the treatment epigastric pain that the object of the invention provides produce effect to the treatment of acute or chronic gastritis, gastric ulcer, chronic atrophic gastritis, dyspepsia, chronic viral hepatitis B etc.
Theoretical foundation of the present invention: " Longevity and Life Preservation ": " the gastric abscess person, how because of self-indulgent food, it is sad to like, and throws off restraint the hot wine of food, fries in shallow oil Bo, and the cold and cool raw food of ending a hunger strike decreases towards eating dusk, and day long-pending moon is dark, from Yu Chengji; From amassing into expectorant, phlegm-fire decocts, and the also absurd row of blood, expectorant blood are assorted mutually, hinder lifting, thus gastralgia, the acid regurgitation belch, noisy nauseating, all the gradually person of diaphragm regurgitation is also." " husband hypochondriac pain person, the cloudy Liver Channel of fainting be disease also.Its disease is drawn lower abdomen from hypochondrium pain, also ought look the inside and outside heresy of being felt and controls it.If the few sun of typhoid fever, deaf hypochondriac pain, wind and cold is attacked and is association's pain, and this exopathogenic factor is also.If hinder because of rage and to touch, grieved depressed, the diet transition, cold and hot imbalance, top servant's impairment of the configuration, or the accumulation of phlegm multiple abscess fights with blood mutually in the side of body, can be pain all, and this endogenous cause of ill is also.
The epigastric pain disease comprises acute or chronic gastritis, gastric ulcer, chronic atrophic gastritis, dyspepsia etc.
Specifically, a kind of oral drugs for the treatment of epigastric pain, it is to make with the following weight parts material medicine:
4～6 parts on 4～6 parts of Pericarpium Citri Reticulatae Virides of 5～12 parts of Pericarpium Citri Reticulataes of Cortex Magnoliae Officinalis
4～6 parts of 4～6 parts of Rhizoma Chuanxiongs of 4～6 parts of Fructus Aurantii Immaturuss of Rhizoma Cyperi
1～8 part of 4～6 parts of Cortex Moutan of 4～6 portions of Rhizoma Curcumae Longaes of Rhizoma Corydalis
1～7 part of 4～6 parts of Radix Angelicae Sinensis of 4～6 parts of Fructus Amomis of the Radix Paeoniae Alba
1～7 part of 1～8 portion of Flos Caryophylli of 4～9 parts of Fructus Amomi Rotunduss of Fructus Evodiae
4～6 parts of 1～7 part of Radix Aucklandiae of 1～7 portion of Cortex Cinnamomi of Lignum Aquilariae Resinatum
4～6 parts of 4～6 parts of Radix Glycyrrhizae Preparatas of 1～7 part of sodium bicarbonate of Poria.
The preferred medicine of the present invention is to make with the following weight parts material medicine:
3～5 parts on 3～5 parts of Pericarpium Citri Reticulatae Virides of 6～10 parts of Pericarpium Citri Reticulataes of Cortex Magnoliae Officinalis
3～5 parts of 3～5 parts of Rhizoma Chuanxiongs of 3～5 parts of Fructus Aurantii Immaturuss of Rhizoma Cyperi
2～6 parts of 3～5 parts of Cortex Moutans of 3～5 portions of Rhizoma Curcumae Longaes of Rhizoma Corydalis
2～4 parts of 3～5 parts of Radix Angelicae Sinensis of 3～5 parts of Fructus Amomis of the Radix Paeoniae Alba
2～4 parts of 2～6 portions of Flos Caryophyllis of 4～8 parts of Fructus Amomi Rotunduss of Fructus Evodiae
3～5 parts of 2～4 parts of Radix Aucklandiae of 2～4 portions of Cortex Cinnamomis of Lignum Aquilariae Resinatum
3～5 parts of 3～5 parts of Radix Glycyrrhizae Preparatas of 2～4 parts of sodium bicarbonate of Poria.
Cortex Magnoliae Officinalis in the medicine of the present invention, Fructus Aurantii Immaturus, Rhizoma Cyperi, Rhizoma Corydalis material medicine are concocted as follows: Cortex Magnoliae Officinalis adopts processed with Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus to adopt parched with bran, Rhizoma Corydalis to adopt vinegar stir-fry, Rhizoma Cyperi to adopt vinegar system.
The present invention is to be that main Western medicine is the compound preparation of assisting with Chinese medicine.In the side with Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Rhizoma Cyperi depressed liver-energy dispersing and QI regulating, reduce phlegm except that painful abdominal mass be monarch drug; Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Cortex Moutan, Radix Paeoniae Alba promoting flow of QI and blood, blood-activating analgetic, the merit that enhancing principal agent soothing liver-QI is separated the stasis of blood is a ministerial drug; Fructus Amomi, Radix Aucklandiae (Radix Vladimiriae), Fructus Amomi Rotundus, Flos Caryophylli, Lignum Aquilariae Resinatum, Cortex Cinnamomi, Fructus Evodiae, Poria is drying damp and strengthening spleen, warming middle-JIAO to relieve pain, and the sodium bicarbonate relieving gastric hyperacidity to alleviate stomachache is adjuvant drug altogether; Radix Glycyrrhizae Preparata relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription are messenger drug.All medicine compatibilities, depressed liver-energy dispersing and QI regulating, dampness and in, blood-activating analgetic, then the irritability bar reaches, spleen fortune is unimpeded, vomits oh, noisy, all diseases of pain can disappear.As a whole, the prescription of this medicine principles of formulating prescriptions that meet traditional Chinese medical theory basis and monarch, minister, help, make.This product has liver-smoothing, qi-regulating, changes the effect of the relieving distension that stagnates, the clinical depression of liver-QI that is mainly used in, both sides of the chest distending pain, gastral cavilty twinge, distension and fullness in the abdomen, acid regurgitation, the noisy treatment of feeling sick.
Pharmacological research shows: medicine of the present invention have regulate gastrointestinal motility function, antiulcer, function of gallbladder promoting, protect the liver, effect such as antibiotic, antiinflammatory; Nervus centralis there are calmness, analgesic activity; Cardiovascular system, respiratory system there is certain effect.
1, to the influence of gastrointestinal function: Pericarpium Citri Reticulatae volatile oil, Pericarpium Citri Reticulatae Viride volatile oil and Cortex Cinnamomi, Flos Caryophylli have gentle stimulation to gastrointestinal function, can promote gastric secretion, get rid of the enteral pneumatosis, showed the effect that fragrance is good for the stomach, but the decocting liquid composition of Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, then to gastrointestinal function by inhibitory action, Fructus Aurantii Immaturus has dual nature to the effect of the intestines and stomach smooth muscle; Rhizoma Cyperi, Lignum Aquilariae Resinatum, Fructus Evodiae, the Radix Paeoniae Alba, Radix Glycyrrhizae have inhibitory action to gastrointestinal motility, can remove the spasm of experimental animal models ileum; Radix Aucklandiae (Radix Vladimiriae) water extract, volatile oil, total alkaloids are to the existing slight excitation of rat small intestine, and tonicity and rhythmicity all obviously descend subsequently.
2, antiulcer: Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Fructus Amomi, Flos Caryophylli, Rhizoma Corydalis, Rhizoma Curcumae Longae, Fructus Evodiae, the Radix Paeoniae Alba, Cortex Cinnamomi etc. all have antiulcer action to a certain degree, and damage at the year end has the better protect effect to the zoopery stomach.
3, function of gallbladder promoting, protect the liver: Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi, Flos Caryophylli, Rhizoma Curcumae Longae, Fructus Evodiae, the Radix Paeoniae Alba, Radix Glycyrrhizae etc. have certain function of gallbladder promoting and hepatoprotective effect; as Pericarpium Citri Reticulatae Viride decocting liquid the hepatic injury rat that normal and carbon tetrachloride cause all there is stronger choleretic effect; can promote bile secretion; improve bile flow, and to hepatocyte function by protective effect.
4, antibiotic, antiinflammatory action: Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Rhizoma Cyperi, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae), Rhizoma Curcumae Longae, Fructus Evodiae, the Radix Paeoniae Alba, Cortex Moutan etc. have antimicrobial antiphlogistic in various degree to do usefulness, antivirus action is also arranged individually, as the Cortex Magnoliae Officinalis decoct spectrum antibacterial action is arranged, experiment in vitro, Cortex Magnoliae Officinalis all has antibacterial action to staphylococcus, Hemolytic streptococcus, diphtheria corynebacterium, escherichia coli, Bacillus proteus, dysentery bacterium etc.The antibacterial action of decoct, not destroyed because of heating.
5, to the effect of nervus centralis: Cortex Magnoliae Officinalis, Rhizoma Cyperi, Fructus Amomi, Lignum Aquilariae Resinatum, Flos Caryophylli, Rhizoma Corydalis, Fructus Evodiae, the Radix Paeoniae Alba, Cortex Moutan, Cortex Cinnamomi show as the main effect of nervus centralis: calmness, analgesia, analgesic, convulsion.As the Rhizoma Cyperi ethanol extract the microbial rat fever of injection yeast there is refrigeration function; Hot plate method experimental results show that.20% cyperol extract, subcutaneous injection can obviously improve mice pain territory.
The clinical treatment that is mainly used in acute or chronic gastritis, gastric ulcer, chronic atrophic gastritis, dyspepsia, chronic viral hepatitis B etc. of the present invention.Show through clinical experiment: the total effective rate of this product treatment chronic gastritis is 94.7%; The total effective rate of treatment gastric ulcer, chronic atrophic gastritis is 93.9%; Treating dyspeptic total effective rate is 96.1%, and the treatment to chronic viral hepatitis B simultaneously also produces effect very much.In clinical use, do not see relevant untoward reaction.
The specific embodiment
Prescription of the present invention following (weight portion):
4～6 parts on 4～6 parts of Pericarpium Citri Reticulatae Virides of 5～12 parts of Pericarpium Citri Reticulataes of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens)
4～6 parts of 4～6 parts of Rhizoma Chuanxiongs of 4～6 parts of Fructus Aurantii Immaturuss of Rhizoma Cyperi (vinegar system) (parched with bran)
1～8 part of 4～6 parts of Cortex Moutan of 4～6 portions of Rhizoma Curcumae Longaes of Rhizoma Corydalis (vinegar stir-fry)
1～7 part of 4～6 parts of Radix Angelicae Sinensis of 4～6 parts of Fructus Amomis of the Radix Paeoniae Alba (stir-fry)
1～7 part of 1～8 portion of Flos Caryophylli of 4～9 parts of Fructus Amomi Rotunduss of Fructus Evodiae
4～6 parts of 1～7 part of Radix Aucklandiae of 1～7 portion of Cortex Cinnamomi of Lignum Aquilariae Resinatum
4～6 parts of 1～7 part of sodium bicarbonate 4-6 of Poria part Radix Glycyrrhizae Preparatas
Above-mentioned raw materials in weight portion is the medicament of formulation method preparation routinely.
Embodiment 1 (unit of weight: gram, down together):
Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 6～10 Pericarpium Citri Reticulataes 3～5 Pericarpium Citri Reticulatae Virides 3～5
Rhizoma Cyperi (vinegar system) 3～5 Fructus Aurantii Immaturuss (parched with bran) 3～5 Rhizoma Chuanxiongs 3～5
Rhizoma Corydalis (vinegar stir-fry) 3～5 Rhizoma Curcumae Longaes 3～5 Cortex Moutans 2～6
The Radix Paeoniae Alba (stir-fry) 3～5 Fructus Amomis 3～5 Radix Angelicae Sinensis 2～4
Fructus Evodiae 4～8 Fructus Amomi Rotunduss 2～6 Flos Caryophyllis 2～4
Lignum Aquilariae Resinatum 2～4 Cortex Cinnamomis 2～4 Radix Aucklandiae 3～5
Poria 2～4 sodium bicarbonate 3～5 Radix Glycyrrhizae Preparatas 3～5.
Embodiment 2:
Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 8 Pericarpium Citri Reticulataes 4 Pericarpium Citri Reticulatae Virides 4
Rhizoma Cyperi (vinegar system) 4 Fructus Aurantii Immaturuss (parched with bran) 4 Rhizoma Chuanxiongs 4
Rhizoma Corydalis (vinegar stir-fry) 4 Rhizoma Curcumae Longaes 4 Cortex Moutans 4
The Radix Paeoniae Alba (stir-fry) 4 Fructus Amomis 4 Radix Angelicae Sinensis 3
Fructus Evodiae 6 Fructus Amomi Rotunduss 4 Flos Caryophyllis 3
Lignum Aquilariae Resinatum 3 Cortex Cinnamomis 3 Radix Aucklandiae 4
Poria 3 sodium bicarbonate 4 Radix Glycyrrhizae Preparatas 4.
Above-mentioned raw materials in weight portion is pulverized, made the watered pill by the preparation method of the watered pill.
The instructions of taking of this product is: oral, and one time 20 ball (containing former medicine 2 grams), 2 times on the one; Warm water delivery service.
Embodiment 3:
Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 8 Pericarpium Citri Reticulataes 4 Pericarpium Citri Reticulatae Virides 4
Rhizoma Cyperi (vinegar system) 4 Fructus Aurantii Immaturuss (parched with bran) 4 Rhizoma Chuanxiongs 4
Rhizoma Corydalis (vinegar stir-fry) 4 Rhizoma Curcumae Longaes 4 Cortex Moutans 4
The Radix Paeoniae Alba (stir-fry) 4 Fructus Amomis 4 Radix Angelicae Sinensis 3
Fructus Evodiae 6 Fructus Amomi Rotunduss 4 Flos Caryophyllis 3
Lignum Aquilariae Resinatum 3 Cortex Cinnamomis 3 Radix Aucklandiae 4
Poria 3 sodium bicarbonate 4 Radix Glycyrrhizae Preparatas 4.
Above-mentioned raw materials in weight portion is pulverized, made hard capsule by the preparation method of capsule.
The instructions of taking of this product is: oral, and one time 5 (containing former medicine 2 restrains), 2 times on the one; Warm water delivery service.
The present invention fills a prescription and can also make other dosage form according to existing pharmaceutical technology, is not limited only to pill and capsule.
It is as follows to treat 106 routine epigastric pain disease clinical observation situation reports.
One, clinical data:
1, case is selected: all 106 examples are organized in treatment, all through pathological diagnosis, are diagnosed as the epigastric pain disease, wherein anxious slowly property gastritis 57 examples, gastric ulcer 49 examples.
2, diagnosis basis: diagnose mainly according to clinical symptoms gastroscope finding and pathological diagnosis.
3, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs: according in November, 1989 CAIM (Chinese Association Of Integrative Medicine) digestive system disease Professional Committee diagnosis tentative standard.
4, Therapeutic Method: all inactive other medicines of treatment group and treatment, oral, one time 5 (containing former medicine 2 restrains), 2 times on the one; Warm water delivery service.
5, observation index: before, during and after the treatment, observe the symptoms in detail and the sign variation, note is in clinical observation table, and related immune is learned detection before and after the treatment, does pathologic findings such as gastroscope.
6, result:
(1), curative effect: among the 106 routine patients, acute or chronic gastritis 57 examples wherein, clinical cure 32 examples account for 56.1% in the recent period; Produce effects 17 examples account for 29.8%; Effective 5 examples account for 8.8%; Invalid 3 examples account for 5.3%; Total effective rate is 94.7%;
Gastric ulcer 49 examples, clinical cure 32 examples account for 65.3% in the recent period; Produce effects 10 examples account for 20.4%; Effective 4 examples account for 8.2%; Invalid 3 examples account for 6.1%; Total effective rate is 93.9%.
Through the patient's clinical symptoms change such as the following table of the present invention's treatment, from following table as can be seen,
The present invention begins to improve to most of epigastric pain disease symptom in a week, according to the patient who takes the course of treatment, effect is clearly arranged all.
Claims (1)
1. oral drugs for the treatment of gastric abscess is characterized in that making with the following weight parts material medicine:
4～6 parts on 4～6 parts of Pericarpium Citri Reticulatae Virides of 5～12 parts of Pericarpium Citri Reticulataes of Cortex Magnoliae Officinalis
4～6 parts of 4～6 parts of Rhizoma Chuanxiongs of 4～6 parts of Fructus Aurantii Immaturuss of Rhizoma Cyperi
1～8 part of 4～6 parts of Cortex Moutan of 4～6 portions of Rhizoma Curcumae Longaes of Rhizoma Corydalis
1～7 part of 4～6 parts of Radix Angelicae Sinensis of 4～6 parts of Fructus Amomis of the Radix Paeoniae Alba
1～7 part of 1～8 portion of Flos Caryophylli of 4～9 parts of Fructus Amomi Rotunduss of Fructus Evodiae
4～6 parts of 1～7 part of Radix Aucklandiae of 1～7 portion of Cortex Cinnamomi of Lignum Aquilariae Resinatum
4～6 parts of 4～6 parts of Radix Glycyrrhizae Preparatas of 1～7 part of sodium bicarbonate of Poria;
And Cortex Magnoliae Officinalis wherein, Fructus Aurantii Immaturus, Rhizoma Cyperi, Rhizoma Corydalis, Radix Paeoniae Alba material medicine are concocted as follows: Cortex Magnoliae Officinalis adopts processed with Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus to adopt parched with bran, Rhizoma Corydalis to adopt vinegar stir-fry, Rhizoma Cyperi to adopt vinegar system, Radix Paeoniae Alba parch.
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| CN102038908B (en) * | 2009-10-22 | 2012-02-29 | 天津中新药业集团股份有限公司达仁堂制药厂 | Detection method of tambac depression-alleviating pill as traditional Chinese medical preparation |
| CN101773633B (en) * | 2010-04-08 | 2011-06-01 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating gastric ulcer |
| CN102335388B (en) * | 2010-07-20 | 2013-06-05 | 天津中新药业集团股份有限公司达仁堂制药厂 | Chinese medicine composition for soothing liver, removing stagnation, stimulating appetite, and promoting digestion and preparation method thereof |
| CN102145143B (en) * | 2011-03-30 | 2013-04-03 | 李明盛 | Pharmaceutical composition for treatment of gastritis and preparation method of pharmaceutical composition |
| CN104013720A (en) * | 2014-03-24 | 2014-09-03 | 桑运锋 | Traditional Chinese medicine powder for treating gastric blood stasis type epigastric pain |
| CN104208563A (en) * | 2014-09-22 | 2014-12-17 | 刘瑞云 | Medicine for treating gastritis |
| CN104435982A (en) * | 2014-11-24 | 2015-03-25 | 贵州安顺隆秦民族医药开发研究所 | Traditional Chinese medicinal composition for treating acute and chronic gastritis |
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| CN101199831A (en) * | 2007-12-18 | 2008-06-18 | 山东步长制药有限公司 | Chinese medicine capsule dose for treating gastric cavity ache, producing method and quality controlling method |
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| CN1682772A (en) * | 2002-12-20 | 2005-10-19 | 焦长安 | Medicine for treating chronic gastropathy |
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