CN105963479A - Method for extracting paris polyphylla saponin - Google Patents
Method for extracting paris polyphylla saponin Download PDFInfo
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- CN105963479A CN105963479A CN201610436176.0A CN201610436176A CN105963479A CN 105963479 A CN105963479 A CN 105963479A CN 201610436176 A CN201610436176 A CN 201610436176A CN 105963479 A CN105963479 A CN 105963479A
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- rhizoma paridis
- ethanol
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- enzymolysis
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- 239000001397 quillaja saponaria molina bark Substances 0.000 title claims abstract description 27
- 229930182490 saponin Natural products 0.000 title claims abstract description 27
- 150000007949 saponins Chemical class 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 26
- 241000244987 Daiswa polyphylla Species 0.000 title abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 72
- 239000000843 powder Substances 0.000 claims abstract description 18
- 102000004190 Enzymes Human genes 0.000 claims abstract description 13
- 108090000790 Enzymes Proteins 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims description 30
- 238000000605 extraction Methods 0.000 claims description 19
- 239000000284 extract Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 abstract 4
- 239000007788 liquid Substances 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000874 microwave-assisted extraction Methods 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 241000223101 Paris cronquistii Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- -1 aminoacid Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229930002600 steroidal saponin Natural products 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for extracting paris polyphylla saponin. The method includes the following steps that 1, paris polyphylla is smashed to powder of 100 meshes; 2, a proper amount of distilled water and biological enzyme are added into the powder in the step 1, enzymolysis is carried out for 2 days to 4 days at the normal temperature, and a raw enzymolysis material is obtained; 3, ethyl alcohol of 60%-70% is added into the raw enzymolysis material in the step 2, wherein the amount of the ethyl alcohol is 20 times to 60 times of that of the raw enzymolysis material, and the mixture is soaked for 1 hour to 2 hours; 4, the raw enzymolysis material soaked by the ethyl alcohol in the step 3 is put into a microwave oven, microwave processing is carried out for 120 seconds when the power is 120 w to 180 w, extracting and filtering are carried out, residues are soaked with the same-volume ethyl alcohol and subjected to microwave processing when the power is 120 w to 180 w, the product is repeatedly extracted for two times and merged for three times, and the filtered liquid is extracting liquid of the paris polyphylla saponin. According to the method, the operation method is simple, and extracting efficiency is high.
Description
Technical field
The invention belongs to the extractive technique field of Rhizoma Paridis saponin, further relate to the extraction of a kind of Rhizoma Paridis saponin
Method.
Background technology
Rhizoma Paridis, also known as Paris polyphylla, is the general term of Liliaceae paris plant, is loaded in name head of Rhizoma Paridis
Shennong's Herbal.The paris plant whole world has 24 kinds, and China's most species has 19 kinds, its
Middle southwest each province's district's kind and resource are the abundantest.Common kind has magnificent Rhizoma Paridis, Rhizoma Paridis and one, seven leaves
Flower.Medicinal has magnificent Rhizoma Paridis, Rhizoma Paridis, Paris polyphylla, narrow leaf Rhizoma Paridis, long connective Rhizoma Paridis, Hainan
Rhizoma Paridis, P. cronquistii, south heavy building." Chinese Pharmacopoeia 2005 version record for Rhizoma Paridis and seven leaves one
The dry rhizome of branch flower.This product bitter in the mouth, cold nature, slightly poisonous, return Liver Channel, there is heat-clearing and toxic substances removing, detumescence
Pain relieving, effect of cool liver arresting convulsion, take out for ulcerative carbuncle, laryngopharynx swelling and pain, venom, traumatic pain, cool breeze
The disease such as jerk.In recent years, along with going deep into of research, the medical value of Rhizoma Paridis is by pay attention to day by day.Rhizoma Paridis main
Effective ingredient is steroidal saponin, and containing compounds such as aminoacid, sterone, ecdyson, flavonoid glycosides.
Traditional Rhizoma Paridis extracts and is substantially employing infusion process, supercritical ultrasonics technology and heating reflux method, these methods
Although the time of use is relatively more long, but extraction effect is general.And microwave is as a kind of new extractive technique, its
Principle is in microwave field, and the difference absorbing microwave ability makes some region or the extraction system of base matter
In some component heated by selectivity separate from matrix or system so that taken material by leather, enter people
In the extractant of, microwave absorption capacity relative mistake less to dielectric constant；Microwave extraction have equipment simple,
Applied widely, extraction efficiency is high, favorable reproducibility, time-consuming, save reagent, pollute the features such as little.
Summary of the invention
In view of this, it is an object of the invention to provide the extracting method of a kind of Rhizoma Paridis saponin, it will by using
Rhizoma Paridis after enzymolysis is dissolved in ethanol, and then by microwave extraction, extraction efficiency is high, time-consuming, pollutes little,
Easy to use.
The present invention solves the problems referred to above by techniques below means:
The extracting method of a kind of Rhizoma Paridis saponin, comprises the following steps:
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 2-4 days, obtains enzyme
Solve raw material；
(3) the enzymolysis raw material of step (2) is added 20-60 times amount 60%-70% soak with ethanol 1-2 hour；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 120-180
Watt microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 120-180 watt of microwave of power
Process, repeat extraction twice, merge the filtrate of 3 times, be the extracting solution of Rhizoma Paridis saponin.
Further, in described step (3), the enzymolysis raw material of step (2) is added 30 times amount 60%-70%
Soak with ethanol 1 hour.
Further, in described step (3), the enzymolysis raw material of step (2) is added 20-60 times amount 60%-70%
Soak with ethanol 1.5 hours.
Further, in described step (3), the enzymolysis raw material of step (2) is added 20-60 times amount 65%
Soak with ethanol 1-2 hour.
Further, in described step (4), the power of described microwave oven is 150 watts.
Beneficial effects of the present invention is as follows:
By by Rhizoma Paridis enzymolysis in the present invention, and it is dissolved in ethanol, then by microwave in a range of merit
Extracting in rate, extraction effect is good, time-consuming, and equipment is simple, it is adaptable to small test or advise greatly
The commercial production of mould.
Detailed description of the invention
The following is the specific embodiment of the present invention, technical scheme is further described, but this
Invention is not limited in these embodiments.
The extracting method of a kind of Rhizoma Paridis saponin of the present invention, comprises the following steps:
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 2-4 days, obtains enzyme
Solve raw material；
(3) the enzymolysis raw material of step (2) is added 20-60 times amount 60%-70% soak with ethanol 1-2 hour；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 120-180
Watt microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 120-180 watt of microwave of power
Process, repeat extraction twice, merge the filtrate of 3 times.
The extracting method that the present invention provides, by using novel microwave technology to extract, extracting method letter
Single, time-consuming, efficiency is high, it is adaptable to small test and commercial production, simultaneously the containing of saponin in Rhizoma Paridis
Amount height, impurity is few.
Embodiment 1
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 2 days, obtains enzymolysis
Raw material；
(3) the enzymolysis raw material of step (2) is added 60 times amount 70% soak with ethanol 2 hours；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 180 watts
Microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 180 watts of microwave treatment of power,
Repeat extraction twice, merge the filtrate of 3 times, be the extracting solution of Rhizoma Paridis saponin.
Through calculating, the extraction ratio of Rhizoma Paridis saponin is 90.61%.
Embodiment 2
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 3 days, obtains enzymolysis
Raw material；
(3) the enzymolysis raw material of step (2) is added 20 times amount 60% soak with ethanol 1 hour；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 120 watts
Microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 120 watts of microwave treatment of power,
Repeat extraction twice, merge the filtrate of 3 times, be the extracting solution of Rhizoma Paridis saponin.
Through calculating, the extraction ratio of Rhizoma Paridis saponin is 89.60%.
Embodiment 3
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 2.5 days, obtains enzyme
Solve raw material；
(3) the enzymolysis raw material of step (2) is added 30 times amount 60% soak with ethanol 1.2 hours；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 140 watts
Microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 140 watts of microwave treatment of power,
Repeat extraction twice, merge the filtrate of 3 times, be the extracting solution of Rhizoma Paridis saponin.
Through calculating, the extraction ratio of Rhizoma Paridis saponin is 91.31%.
Embodiment 4
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 3 days, obtains enzymolysis
Raw material；
(3) the enzymolysis raw material of step (2) is added 40 times amount 65% soak with ethanol 1 hour；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 160 watts
Microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 160 watts of microwave treatment of power,
Repeat extraction twice, merge the filtrate of 3 times, be the extracting solution of Rhizoma Paridis saponin.
Through calculating, the extraction ratio of Rhizoma Paridis saponin is 89.90%.
Embodiment 5
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 4 days, obtains enzymolysis
Raw material；
(3) the enzymolysis raw material of step (2) is added 50 times amount 68% soak with ethanol 2 hours；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 170 watts
Microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 170 watts of microwave treatment of power,
Repeat extraction twice, merge the filtrate of 3 times, be the extracting solution of Rhizoma Paridis saponin.
Through calculating, the extraction ratio of Rhizoma Paridis saponin is 89.86%.
Being proved by above-described embodiment, technical scheme can not only effectively extract the soap in Rhizoma Paridis
Glycosides composition, and simple to operate, time-consuming.
Finally illustrate, above example only in order to technical scheme to be described and unrestricted, although
With reference to preferred embodiment, the present invention is described in detail, it will be understood by those within the art that,
Technical scheme can be modified or equivalent, without deviating from technical solution of the present invention
Objective and scope, it all should be contained in the middle of scope of the presently claimed invention.
Claims (5)
1. the extracting method of a Rhizoma Paridis saponin, it is characterised in that: comprise the following steps:
(1) Rhizoma Paridis is ground into 100 mesh powder；
(2) powder in step (1) is added appropriate distilled water and enzyme room temperature enzymolysis 2-4 days, obtains enzyme
Solve raw material；
(3) the enzymolysis raw material of step (2) is added 20-60 times amount 60%-70% soak with ethanol 1-2 hour；
(4) enzymolysis raw material through soak with ethanol in step (3) is placed in microwave oven, power 120-180
Watt microwave treatment, extracts after 120 seconds and filters, the ethanol of residue same volume, 120-180 watt of microwave of power
Process, repeat extraction twice, merge the filtrate of 3 times, be the extracting solution of Rhizoma Paridis saponin.
The extracting method of a kind of Rhizoma Paridis saponin the most according to claim 1, it is characterised in that: described step
Suddenly, in (3), the enzymolysis raw material of step (2) is added 30 times amount 60%-70% soak with ethanol 1 hour.
The extracting method of a kind of Rhizoma Paridis saponin the most according to claim 1, it is characterised in that: described step
Suddenly, in (3), the enzymolysis raw material of step (2) is added 20-60 times amount 60%-70% soak with ethanol 1.5 hours.
The extracting method of a kind of Rhizoma Paridis saponin the most according to claim 1, it is characterised in that: described step
Suddenly, in (3), the enzymolysis raw material of step (2) is added 20-60 times amount 65% soak with ethanol 1-2 hour.
The extracting method of a kind of Rhizoma Paridis saponin the most according to claim 1, it is characterised in that: described step
Suddenly, in (4), the power of described microwave oven is 150 watts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610436176.0A CN105963479A (en) | 2016-06-17 | 2016-06-17 | Method for extracting paris polyphylla saponin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610436176.0A CN105963479A (en) | 2016-06-17 | 2016-06-17 | Method for extracting paris polyphylla saponin |
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| Publication Number | Publication Date |
|---|---|
| CN105963479A true CN105963479A (en) | 2016-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610436176.0A Pending CN105963479A (en) | 2016-06-17 | 2016-06-17 | Method for extracting paris polyphylla saponin |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108531318A (en) * | 2018-07-21 | 2018-09-14 | 安溪县凤城建金产品外观设计服务中心 | A kind of preparation process of the soap containing paris polyphylla extract |
| CN110663709A (en) * | 2019-11-15 | 2020-01-10 | 中南民族大学 | Preparation method and application of paris polyphylla extractive solution |
| CN118787585A (en) * | 2024-09-12 | 2024-10-18 | 昆明远方生物制品有限公司 | A Yunnan Paris polyphylla extract with scalp inflammatory symptom repairing function and its application |
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Patent Citations (2)
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| CN102234307A (en) * | 2011-05-06 | 2011-11-09 | 南京泽朗医药科技有限公司 | Method for extracting and separating pardifomoside from Lysimachia paridiformis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108531318A (en) * | 2018-07-21 | 2018-09-14 | 安溪县凤城建金产品外观设计服务中心 | A kind of preparation process of the soap containing paris polyphylla extract |
| CN110663709A (en) * | 2019-11-15 | 2020-01-10 | 中南民族大学 | Preparation method and application of paris polyphylla extractive solution |
| CN118787585A (en) * | 2024-09-12 | 2024-10-18 | 昆明远方生物制品有限公司 | A Yunnan Paris polyphylla extract with scalp inflammatory symptom repairing function and its application |
| CN118787585B (en) * | 2024-09-12 | 2024-12-17 | 云南远方生物医药有限公司 | Yunnan rhizoma paridis extract with function of repairing dermatitis capitis symptoms and application |
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