CN103550129B - Plant composite polysaccharide, Preparation Method And The Use - Google Patents
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- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to plant composite polysaccharide, Preparation Method And The Use.Wherein plant composite polysaccharide is prepared from by the crude drug of following weight proportion: Pollen Pini 30 ~ 80 weight portion; The Radix Astragali 10 ~ 40 weight portion; Poria 5 ~ 25 weight portion; Radix Salviae Miltiorrhizae 5 ~ 20 weight portion; Radix Angelicae Sinensis 3 ~ 20 weight portion; Radix Glycyrrhizae 2 ~ 15 weight portion.Plant composite polysaccharide of the present invention can be used for preparation and has moisturizing, defying age and skin repair function skin care item.As protective skin cream, skin protection gel, skin care milk, surfactant etc., its preparation method is conventional method.
Description
Technical field
The present invention relates to technical field of skin care, particularly relate to plant composite polysaccharide, its preparation method, and the purposes of plant composite polysaccharide in cosmetics preparation.
Background technology
The develop rapidly of modern science and technology and extensive use bring brand-new opportunity to develop to skin care item industry, skin care item from the basic skin care item for the purpose of clean skin, skin moistening to slow down aging, beautify the complexion for the purpose of effect type skin care item future development, the research and development of skin care item experienced by chemistry beauty treatment, plant beauty, and the target just towards biological beauty and gene beauty treatment strides forward.
Vegetable polysaccharides is a kind of biomacromolecule be extensively present in plant roots stem and leaf, it be polymerized by glycosidic bond by multiple monosaccharide molecule, the polyhydroxylated polymer of the dewater ketone group containing that formed or aldehyde radical.It is the important composition composition of human body skin skin corium, it is the very important nutrient substance of organism, in the multiple vital movement of body, play irreplaceable effect, and transport with cell recognition, Organism immunoregulation, intercellular substance, the old and feeble apoptosis of cell is closely related.Vegetable polysaccharides, as the application of both effectiveness skin care product additive in skin care item, is an important directions of biological beauty, can produce hide fiber in moisturizing, slow down aging, promotion and become cell proliferation and the several functions such as to beautify the complexion.In addition, compared with the medicine of chemosynthesis, vegetable polysaccharides also has the feature of low toxicity, and therefore it has boundless development prospect.
In current industry, the extraction and preparation technique of the single vegetable polysaccharidess such as Hericium erinaceus (Bull. Ex Fr.) Pers., Agaricus blazei Murrill, Bulbus Allii, Herba Hedyotidis Diffusae, Fructus Jujubae slag, Auricularia, Aloe, the Radix Astragali is studied.Conventional extracting method has decoction and alcohol sedimentation technique, diluted alkaline extraction, diluted acid extraction and enzyme process etc.But use the polysaccharide of single prescription can not comprehensively solve various problem in skin care item, therefore be necessary by " monarch " of the traditional Chinese medical science theoretical, the plant containing polysaccharide component with synergistic function is carried out compound recipe, the extraction and preparation technique after research plant compound recipe.At present, the research to plant composite polysaccharide extraction and preparation technique is had no.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of plant composite polysaccharide, its preparation method, and plant composite polysaccharide is applied to the exploitation with moisturizing, defying age and skin repair function skin care item.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of plant composite polysaccharide, is prepared from by the crude drug of following weight proportion:
Preferably, plant composite polysaccharide is made up of the crude drug of following weight proportion:
The present invention is according to " monarch " of theory of Chinese medical science, and select main component to be the Chinese medicine of polysaccharide, each medicine act as:
Pollen Pini: sweet in the mouth, temperature.Return liver, spleen channel.Dampness, astringing to arrest bleeding.For eczema, impetigo, skin erosion, pus is dripping, traumatic hemorrhage, diaper dermatitis.Pine pollen polysaccharide has moisturizing, antioxidation, scavenging free radicals, effect of slow down aging.
Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, breast ventral spine pain, pyretic arthralgia pain, skin ulcer wound swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Radix Salviae Miltiorrhizae polysaccharide energy promoting blood circulation to restore menstrual flow, has whitening and preserving moisture and protecting skin effect.
The Radix Astragali: nature and flavor are sweet, warm.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.Astragalus polysaccharides mainly contains glucosan and heteropolysaccharide, and research shows to have good effects in anticoagulation, antithrombotic, antiinflammatory, Adjust-blood lipid and reduction blood viscosity etc.
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver; The heart; Spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis polysaccharide has moisture-keeping efficacy, is enriching blood, removes free radical, improves immunity, is having remarkable effect in antitumor, Antiradiation injury etc.
Poria: Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Pachyman, primarily of compositions such as pachyman, glucose, sucrose and fructose, has inhibitory action to various bacteria; Have promote cell division, complement activation, mutation, antitumor, anticancer, strengthen the biological activity such as immunity.
Radix Glycyrrhizae: sweet in the mouth, flat.GUIXIN, spleen, lung, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Angelica Polysaccharide has moisturizing, scavenging hydroxyl, immunity moderation, suppresses the skin-care effects such as allergy.
In above-mentioned each crude drug, pine pollen polysaccharide and Radix Salviae Miltiorrhizae polysaccharide have effect of moisturizing, antioxidation, blood circulation promoting and blood stasis dispelling, defying age, are monarch drug; The Radix Astragali, Radix Angelicae Sinensis polysaccharide benefiting vital QI and blood, be conducive to blood circulation promoting and blood stasis dispelling, can skin whitening be ministerial drug; Pachyman, has promotion cell division, and accelerate metabolism, effect of moisturizing is adjuvant drug; Angelica Polysaccharide immunity moderation, suppress allergy, coordinating the actions of various ingredients in a prescription, for making medicine.This plant composite polysaccharide is used in skin care item, has synergistic function, skin protection moisturizing, antioxidation, enhance metabolism and comprehensively in blood circulation promoting and blood stasis dispelling etc. to play a role, thus reach real skin protection object.
The preparation method of plant composite polysaccharide described above, comprises the following steps:
Step 1, takes each crude drug respectively according to plant composite polysaccharide formula consumption;
Step 2; each crude drug is soaked 0.5 ~ 2 hour respectively in water; the mass volume ratio of crude drug and water is 1:15 ~ 50g/ml; mixed liquor be heated to 80 ~ 100 DEG C and be incubated 1.0 ~ 3.0 hours; filter mixed liquor obtains a filtering residue and first-time filtrate, repeats said extracted process obtain secondary filtering residue and secondary filtrate to a filtering residue;
Step 3, first-time filtrate and secondary filtrate mix homogeneously obtain mixing filtrate, and the active carbon adding 8 ~ 20 % by weight in described mixing filtrate decolours, and then filters mixing filtrate;
Step 4, by obtain in step 3 filtrate be cooled to 30 ~ 50 DEG C, carry out vacuum filtration, obtain containing the filtrate of plant compound recipe crude polysaccharides;
Step 5, the chloroform of 1 volume and the mixed liquor of n-butyl alcohol is added to containing in the filtrate of plant compound recipe crude polysaccharides of 6 ~ 12 volumes, shake 30 ~ 60 minutes, chloroform in the mixed liquor of described chloroform and n-butyl alcohol: n-butyl alcohol volume ratio is 4:1, the Denatured protein of centrifugal segregation water layer and solvent layer intersection, centrifugal 2 ~ 5 times repeatedly, obtain the plant compound recipe crude polysaccharides removing foreign protein.
Further, in the preparation method of above-mentioned plant composite polysaccharide, the mass volume ratio of step 2 Raw medicine and water is 1:25 ~ 30g/ml.
Further, in the preparation method of above-mentioned plant composite polysaccharide, filtering in step 3 is utilize 200 ~ 300 order gauzes to filter.
Further, in the preparation method of above-mentioned plant composite polysaccharide, in step 4, vacuum filtration is that vacuum is 0.05 ~ 0.1Mpa, and filter plate fineness is 0.1 ~ 5 micron with plate-and-frame filtration.
The application of plant composite polysaccharide of the present invention in cosmetics preparation.Plant composite polysaccharide compositions of the present invention, can make the skin care item of various dosage form, and as protective skin cream, skin protection gel, skin care milk, surfactant etc., its preparation method is conventional method.Described skin care item preferably include glycerol and/or antiseptic.
The skin protection group product of preparation take plant composite polysaccharide as the external preparation of primary raw material, without any side effects, to skin without any stimulation and untoward reaction.
The using method of skin care item: generally, every day, each painting once, was applied to face sooner or later, and before smearing, first cleaning need smear place.Can use every day, during using product of the present invention, there is no dietetic contraindication.
Detailed description of the invention
Be described principle of the present invention and feature below in conjunction with embodiment, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
Plant composite polysaccharide in embodiment 1, is prepared from by the crude drug of following weight proportion:
The preparation method of described plant composite polysaccharide, comprises the following steps:
Step 1, takes each crude drug respectively according to plant composite polysaccharide formula consumption;
Step 2; each crude drug is soaked 0.5 hour respectively in water; the mass volume ratio of crude drug and water is 1:25g/ml; mixed liquor be heated to 95 DEG C and be incubated 3.0 hours; filter mixed liquor obtains a filtering residue and first-time filtrate, repeats said extracted process obtain secondary filtering residue and secondary filtrate to a filtering residue;
Step 3, first-time filtrate and secondary filtrate mix homogeneously obtain mixing filtrate, and the active carbon adding 16 % by weight in described mixing filtrate decolours, and then filters mixing filtrate;
Step 4, by obtain in step 3 filtrate be cooled to 35 DEG C, carry out vacuum filtration, obtain containing the filtrate of plant compound recipe crude polysaccharides;
Step 5, the chloroform of 1 volume and the mixed liquor of n-butyl alcohol is added to containing in the filtrate of plant compound recipe crude polysaccharides of 8 volumes, shake 50 minutes, chloroform in the mixed liquor of described chloroform and n-butyl alcohol: n-butyl alcohol volume ratio is 4:1, the Denatured protein of centrifugal segregation water layer and solvent layer intersection, centrifugal 4 times repeatedly, obtain the plant compound recipe crude polysaccharides removing foreign protein.
In said method, filtering in step 3 is utilize 200 order gauzes to filter.In step 4, vacuum filtration is that vacuum is 0.05Mpa, and filter plate fineness is 0.1 micron with plate-and-frame filtration.Adopt described preparation method can extract the plant composite polysaccharide of applicable skin care item use preferably.
Embodiment 2
Plant composite polysaccharide in embodiment 1, is prepared from by the crude drug of following weight proportion:
The preparation method of described plant composite polysaccharide, comprises the following steps:
Step 1, takes each crude drug respectively according to plant composite polysaccharide formula consumption;
Step 2; each crude drug is soaked 1.0 hours respectively in water; the mass volume ratio of crude drug and water is 1:35g/ml; mixed liquor is heated to 100 DEG C; be incubated 2.5 hours; filter mixed liquor obtains a filtering residue and first-time filtrate, repeats said extracted process obtain secondary filtering residue and secondary filtrate to a filtering residue;
Step 3, first-time filtrate and secondary filtrate mix homogeneously obtain mixing filtrate, and the active carbon adding 12 % by weight in described mixing filtrate decolours, and then filters mixing filtrate;
Step 4, by obtain in step 3 filtrate be cooled to 45 DEG C, carry out vacuum filtration, obtain containing the filtrate of plant compound recipe crude polysaccharides;
Step 5, the chloroform of 1 volume and the mixed liquor of n-butyl alcohol is added to containing in the filtrate of plant compound recipe crude polysaccharides of 12 volumes, shake 40 minutes, chloroform in the mixed liquor of described chloroform and n-butyl alcohol: n-butyl alcohol volume ratio is 4:1, the Denatured protein of centrifugal segregation water layer and solvent layer intersection, centrifugal 5 times repeatedly, obtain the plant compound recipe crude polysaccharides removing foreign protein.
In said method, filtering in step 3 is utilize 300 order gauzes to filter.In step 4, vacuum filtration is that vacuum is 0.08Mpa, and filter plate fineness is 2 microns with plate-and-frame filtration.Adopt described preparation method can extract the plant composite polysaccharide of applicable skin care item use preferably.
Embodiment 3
Plant composite polysaccharide in embodiment 1, is prepared from by the crude drug of following weight proportion:
The preparation method of described plant composite polysaccharide, comprises the following steps:
Step 1, takes each crude drug respectively according to plant composite polysaccharide formula consumption;
Step 2; each crude drug is soaked 2.0 hours respectively in water; the mass volume ratio of crude drug and water is 1:15g/ml; mixed liquor is heated to 80 DEG C; be incubated 1.5 hours; filter mixed liquor obtains a filtering residue and first-time filtrate, repeats said extracted process obtain secondary filtering residue and secondary filtrate to a filtering residue;
Step 3, first-time filtrate and secondary filtrate mix homogeneously obtain mixing filtrate, and the active carbon adding 20 % by weight in described mixing filtrate decolours, and then filters mixing filtrate;
Step 4, by obtain in step 3 filtrate be cooled to 30 DEG C, carry out vacuum filtration, obtain containing the filtrate of plant compound recipe crude polysaccharides;
Step 5, the chloroform of 1 volume and the mixed liquor of n-butyl alcohol is added to containing in the filtrate of plant compound recipe crude polysaccharides of 10 volumes, shake 30 minutes, chloroform in the mixed liquor of described chloroform and n-butyl alcohol: n-butyl alcohol volume ratio is 4:1, the Denatured protein of centrifugal segregation water layer and solvent layer intersection, centrifugal 2 times repeatedly, obtain the plant compound recipe crude polysaccharides removing foreign protein.
In said method, filtering in step 3 is utilize 200 order gauzes to filter.In step 4, vacuum filtration is that vacuum is 0.1Mpa, and filter plate fineness is 5 microns with plate-and-frame filtration.Adopt described preparation method can extract the plant composite polysaccharide of applicable skin care item use preferably.
Embodiment 4
Plant composite polysaccharide in embodiment 1, is prepared from by the crude drug of following weight proportion:
The preparation method of described plant composite polysaccharide, comprises the following steps:
Step 1, takes each crude drug respectively according to plant composite polysaccharide formula consumption;
Step 2; each crude drug is soaked 1.5 hours respectively in water; the mass volume ratio of crude drug and water is 1:50g/ml; mixed liquor is heated to 85 DEG C; be incubated 1.0 hours; filter mixed liquor obtains a filtering residue and first-time filtrate, repeats said extracted process obtain secondary filtering residue and secondary filtrate to a filtering residue;
Step 3, first-time filtrate and secondary filtrate mix homogeneously obtain mixing filtrate, and the active carbon adding 8 % by weight in described mixing filtrate decolours, and then filters mixing filtrate;
Step 4, by obtain in step 3 filtrate be cooled to 50 DEG C, carry out vacuum filtration, obtain containing the filtrate of plant compound recipe crude polysaccharides;
Step 5, the chloroform of 1 volume and the mixed liquor of n-butyl alcohol is added to containing in the filtrate of plant compound recipe crude polysaccharides of 6 volumes, shake 60 minutes, chloroform in the mixed liquor of described chloroform and n-butyl alcohol: n-butyl alcohol volume ratio is 4:1, the Denatured protein of centrifugal segregation water layer and solvent layer intersection, centrifugal 3 times repeatedly, obtain the plant compound recipe crude polysaccharides removing foreign protein.
In said method, filtering in step 3 is utilize 200 order gauzes to filter.In step 4, vacuum filtration is that vacuum is 0.06Mpa, and filter plate fineness is 4 microns with plate-and-frame filtration.Adopt described preparation method can extract the plant composite polysaccharide of applicable skin care item use preferably.
The application of plant composite polysaccharide of the present invention in cosmetics preparation.Plant composite polysaccharide compositions of the present invention, can make the skin care item of various dosage form, as protective skin cream, skin protection gel, skin care milk, surfactant etc.Preparation method is conventional method.Described skin care item preferably include glycerol and/or antiseptic.
The plant composite polysaccharide that Example 1-4 finally obtains is as active ingredients, and with various adjuvant (as glycerol and/or antiseptic), preparation method prepares various skin-protection product routinely, as protective skin cream, skin protection gel, skin care milk, surfactant etc.
Test example 1 human skin patch
Materials and methods
1, tested material is protective skin cream
The raw materials of protective skin cream:
Component A: Jojoba oil 10g, glyceryl monostearate 2g, cetearyl alcohol 5g, shea butter 4g, olive oil 2g, PEG-100 stearate 4g.
B component: glycerol 5g, butanediol 8g, allantoin 0.1g, xanthan gum 0.2g, deionized water 54.4g.
C component: the plant composite polysaccharide 5g that embodiment 1 obtains.
D component: Ocean essence 0.1g, Methylisothiazolinone 0.2g.
The preparation preparation method of protective skin cream: skin care item prepare conventional method.
2, negative control: blank control sample
The raw materials of blank sample:
Component A: Jojoba oil 10g, glyceryl monostearate 2g, cetearyl alcohol 5g, shea butter 4g, olive oil 2g, PEG-100 stearate 4g.
B component: glycerol 5g, butanediol 8g, allantoin 0.1g, xanthan gum 0.2g, deionized water 59.4g.
C: Ocean essence 0.1g, Methylisothiazolinone 0.2g.
The preparation method of blank sample: skin care item prepare conventional method.
3, experimenter: totally 30 people, male 0 people, female 30 people, at 21 ~ 48 years old age, meets experimenter and volunteers inclusion criteria.
4, patch method: select qualified speckle examination device, with closed patch test method, tested material being about 0.020ml ~ 0.025g drips in speckle examination device, external special adhesive tape sticks in experimenter back, tested material is removed after 24 hours, within 0.5,24,48 hour, observe dermoreaction after removal respectively, by its result of dermoreaction grade scale record in " skin care item hygienic practice " (version in 2007).Result of the test is in table 1.
Table 1 human skin patch result
Human skin patch result shows: in 30 people, skin adverse reaction appears in 0 example; Spot removal and skin care compositions use safety of the present invention is described.
Test example 2 result of use is tested
By protective skin cream prepared by test example 1, receptor is carried out to the test of 28 days.Tester is totally 35 people, female 25 example, and man 10 example, the age was from 28 ~ 50 years old.35 human facial skin's dryings are rough, and dim, skin has mottle.Using method: for being often coated with 2 ~ 3 times beyond the highest heavens.
Use skin after 7 days to start to become moist smooth, use after 14 days, face recovers moist, glossy, elasticity, and what the colour of skin obviously highlighted accounts for 32 examples (91%).Use after 28 days, skin all recovers moist smooth, without dry, dimmed state.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a plant composite polysaccharide, is prepared from by the crude drug of following weight proportion:
2. plant composite polysaccharide according to claim 1, is characterized in that,
3. the preparation method of plant composite polysaccharide described in claim 1 or 2, comprises the following steps:
Step 1, takes each crude drug respectively according to plant composite polysaccharide formula consumption;
Step 2, after each crude drug is soaked 0.5 ~ 2 hour respectively in water, mixing obtains mixed liquor, the mass volume ratio of crude drug and water is 1:15 ~ 50g/ml, mixed liquor be heated to 80 ~ 100 DEG C and be incubated 1.0 ~ 3.0 hours, filter mixed liquor obtains a filtering residue and first-time filtrate, repeats said extracted process obtain secondary filtering residue and secondary filtrate to a filtering residue;
Step 3, first-time filtrate and secondary filtrate mix homogeneously obtain mixing filtrate, and the active carbon adding 8 ~ 20 % by weight in described mixing filtrate decolours, and then filters mixing filtrate;
Step 4, is cooled to 30 ~ 50 DEG C by the filtrate obtained in step 3, carries out vacuum filtration, obtains the filtrate containing plant compound recipe crude polysaccharides;
Step 5, the chloroform of 1 volume and the mixed liquor of n-butyl alcohol is added to containing in the filtrate of plant compound recipe crude polysaccharides of 6 ~ 12 volumes, shake 30 ~ 60 minutes, chloroform in the mixed liquor of described chloroform and n-butyl alcohol: n-butyl alcohol volume ratio is 4:1, the Denatured protein of centrifugal segregation water layer and solvent layer intersection, centrifugal 2 ~ 5 times repeatedly, obtain the plant compound recipe crude polysaccharides removing foreign protein.
4. the preparation method of plant composite polysaccharide according to claim 3, is characterized in that, the mass volume ratio of step 2 Raw medicine and water is 1:25 ~ 30g/ml.
5. the preparation method of plant composite polysaccharide according to claim 3, is characterized in that, filtering in step 3 is utilize 200 ~ 300 order gauzes to filter.
6. the preparation method of plant composite polysaccharide according to claim 3, is characterized in that, in step 4, vacuum filtration is that vacuum is 0.05 ~ 0.1Mpa, and filter plate fineness is 0.1 ~ 5 micron with plate-and-frame filtration.
7. according to the application of plant composite polysaccharide in cosmetics preparation of any one of claim 1-2.
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| CN104489329A (en) * | 2014-12-14 | 2015-04-08 | 河南联合英伟饲料有限公司 | Drug-core type feed particle for resisting canine bacterial diseases and preparation method thereof |
| CN104739710B (en) * | 2015-02-25 | 2017-08-25 | 烟台新时代健康产业日化有限公司 | A kind of skin repair compound and application thereof |
| CN107115383B (en) * | 2017-07-06 | 2021-04-27 | 成都华西珐玛生物科技有限公司 | Skin care/treatment composition having skin xerosis syndrome preventing and treating effect |
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