CN105902418A

CN105902418A - Imitated sebum matrix, external preparation including imitated sebum matrix and application thereof

Info

Publication number: CN105902418A
Application number: CN201610335139.0A
Authority: CN
Inventors: 李苌青
Original assignee: Chongqing Miaoxiu Biotechnology Co Ltd
Current assignee: Chongqing Miaoxiu Biotechnology Co Ltd
Priority date: 2016-05-19
Filing date: 2016-05-19
Publication date: 2016-08-31

Abstract

The invention discloses an imitated sebum matrix, an external preparation including the imitated sebum matrix and application thereof, and belongs to the technical field of cosmetics and medicines. The imitated sebum matrix is prepared from the following raw materials in percentage by weight: 1-60% of lipid, 0.5-20% of natural moisturizing factor and 20-80% of water, wherein the lipid is one or more of triglyceride, animal oil or/and vegetable oil, squalene and wax; the natural moisturizing factor is a mixture of sodium pyrrolidone carboxylate and lactate. The invention further discloses an external preparation including the imitated sebum matrix and application thereof. The imitated sebum matrix does not contain petrochemical materials, has the effects of supplementing sebum, promoting osmosis of active ingredients and the like, and can be used for external preparations such as cosmetics and medicines.

Description

A kind of imitation leather aliphatic radical matter, the external preparation comprising imitation leather aliphatic radical matter and application thereof

Technical field

The external preparation the present invention relates to a kind of imitation leather aliphatic radical matter, comprising imitation leather aliphatic radical matter and application thereof, belong to cosmetics, Field of pharmaceutical technology.

Background technology

General external preparation mainly is become to be grouped into by seven aspects: oils and fats and wax, surfactant, spice, pigment, molten Agent, preservative and functional component (including sun-proof, defying age, smoothing wrinkle, moisturizing etc.).In addition to functional component, other six kinds of compositions The referred to as basic ingredient (referred to as substrate) of external preparation, plays: make skin emolliency, lubricious, moisturizing, gloss；Promotion is oozed Thoroughly；Change formulation aesthetics and denseness；Emulsifying；Plastotype；Flavouring；Toning；The basic role such as antioxidation, sterilization, matrix components determines The color of external preparation, character, fragrance, effect phase and physics and chemistry sanitary index, matrix components adds some different merits Can make the external preparation with different efficacies by composition.Therefore, mostly important ingredient during substrate is external preparation.

At present, the matrix components of mucocutaneous external preparation (including cosmetics and ointment) is many by mineral oil, combination color Element, compound essence, chemical preservative, chemical antioxidants, synthetic surfactant etc. are from oil, the raw material group of coking coal oil Become.And the chemical raw materials such as oil, coking coal oil can produce serious harm to skin, than if any: dermatitis, Pigment Variation, erythema, Scratch where it itches, induce acne, severe patient causes skin carcinoma, etc..The life-time service meeting of the chemical raw material in these oil, coking coal oil source Accelerate the aging of skin.Therefore, find one and skin is had nutrition, moist, enhancing skin resistance, and be safe from harm simultaneously External preparation substrate be particularly important to replace oil, coking coal oil stock substrate.

It practice, the inherent function of skin is exactly sebum secreted, forms ultra-thin protecting film and cover at skin surface, allow Skin is bright and new bright, helps skin surface to have flexibility, alleviates the stimulation that friction produces, prevent the natural moisturizing of skin itself The factor (such as sodium lactate and pyrrolidone sodium carboxylate etc.) and moisture content scatter and disappear, and protection skin is not invaded by antibacterial or foreign substance. Therefore, utilize and promote that the natural physiological function of skin is only the basic road of maintenance skin.

And current, our daily use chemicals cleaning supplies used in everyday make the sebum of our body surface excessively be cleaned, and the most clear Washing the skin surface sebum minimizing caused will promote human body self sebaceous gland to strengthen secretion, and the secretion of long-term over loading ultimately results in skin , finally there are the skin problems such as xerosis cutis, obscure, sensitive, pigmentation, barrier function reduction in adipose gland deterioration.

Therefore, for the skin of most of crowds, require supplementation with sebum composition, alleviate load and the recovery of sebaceous gland Sebaceous gland function, allows skin recover natural gloss and barrier function.Meanwhile, because sebum and the barrier function of skin surface, make The active substance that must be applied by body surface and medicine are difficult to be penetrated into by skin surface internal, it is difficult to play due effect. If some composition of external preparation is same or similar with the composition component of people's sebum, will with skin have the good compatibility and Permeability, therefore active substance and drug osmotic can be effectively facilitated and enter internal, play a role.

Described in view of this, the matrix components of Mucocutaneous external preparation should be same or similar with the composition of skin sebum (referred to as imitation leather aliphatic radical matter), one is to avoid the source chemical raw material harm to skin such as oil, coal tar, and two is supplementary Not enough because excessively cleaning the sebum caused, recover smegma function, allow skin recover natural gloss and barrier function, three are Promote that biological active matter and drug osmotic enter internal, play due effect.And the external preparation comprising imitation leather aliphatic radical matter also must To have: non-stimulated to skin, safety is high；Environmental protection；The compatibility with skin is good, and beneficially medicine or active substance oozes Thoroughly, to the advantage such as Mucocutaneous Preservation, therapeutic effect be good.

Summary of the invention

An object of the present invention, is to provide the imitation leather aliphatic radical of external preparation that is a kind of identical with people's sebum component or that approximate Matter.The imitation leather aliphatic radical matter of the present invention can replace in current external preparation is originated what chemical raw material formed by oil, coal tar etc. Matrix components, it is to avoid skin is endangered by the source such as oil, coal tar chemical raw material.Meanwhile, supplement because excessively cleaning causes Sebum not enough, recover smegma function, allow skin recover natural gloss and barrier function, moreover it is possible to promote biological active matter Enter internal with drug osmotic, play due effect.

The technical scheme is that the imitation leather aliphatic radical matter of a kind of external preparation, including such as The constitutive material of lower percetage by weight: lipid 1～60%, nature moisturizing factor 0.5～20% and water 20～80%, wherein, institute Stating lipid is that triglyceride, animal oil are or/and mixture a kind of or the most several in vegetable oil, Squalene, waxiness, described sky So Moisture factor is pyrrolidone sodium carboxylate and Lactated mixture.

Wherein, triglyceride in described lipid, animal oil are or/and vegetable oil, Squalene, the mixture of waxiness, other group The respective weight divided is 0.1～10 times of triglyceride weight, pyrrolidone sodium carboxylate and breast in described nature moisturizing factor The weight ratio of hydrochlorate is 1:10～10:1.

The present invention, according to bionics principle, chooses composition same or analogous with the natural constituents in sebum and skin texture It is combined, forms the imitation leather aliphatic radical matter in the substrate of mucocutaneous external preparation, the i.e. present invention.The imitation leather fat of the present invention Substrate can replace the matrix components being made up of in current external preparation the source such as oil, coal tar chemical raw material, it is to avoid skin Endangered by the source such as oil, coal tar chemical raw material, supplemented sebum not enough simultaneously, allow skin recover natural gloss and barrier Function, moreover it is possible to promote that biological active matter and drug osmotic enter internal, play due effect.

On the basis of technique scheme, the present invention can also do following improvement.

Further, a kind of or the most several mixing during described animal oil is lanoline, lanolin derivative, stearic acid Thing.

Use and above-mentioned further provide the benefit that: animal oil is rich in saturated and unsaturated fatty acid, with people's sebum Fatty acid is allied substances, good with skin-friendliness, have nutrition, antioxidation, moisturizing, moisten, antiallergic, antipruritic, skin protection Effect.

Further, described lanolin derivative is lanonol, lanoceric acid, pure lanocerin, acetylated lanolin wax, acetyl Change a kind of or the most several mixture in lanonol, polyethylene glycol hydrogenated lanoline.

Further, described vegetable oil is olive oil, soybean oil, Oleum Camelliae, almond oil, Jojoba oil, Oleum Arachidis hypogaeae semen, Semen Gossypii A kind of or the most several mixture in oil, American Avocado Tree oil, Camellia oil, Adeps Bovis seu Bubali resin.

Use and above-mentioned further provide the benefit that: vegetable oil is rich in saturated and unsaturated fatty acid, with people's sebum Fatty acid is allied substances, good with skin-friendliness, have nutrition, antioxidation, moisturizing, moisten, antiallergic, antipruritic, skin protection Effect.

Further, any one mixture during described vegetable oil is Adeps Bovis seu Bubali resin and other vegetable oil above-mentioned.Wherein, Adeps Bovis seu Bubali resin is 1:10～10:1 with the weight ratio of other vegetable oil above-mentioned.

Use and above-mentioned further provide the benefit that: Adeps Bovis seu Bubali resin is compared with other vegetable oil, containing higher saponification Thing, protection skin is not stimulated by external environment, and has smooth emulsion structure, is suitable for infant skin, but its unsaturated lipid Fat acid content is relatively low, and therefore, Adeps Bovis seu Bubali resin has cooperative effect with the mixture of other vegetable oil above-mentioned to skin nursing.

Further, a kind of or the most several during described waxiness is palm wax, candelilla wax, Jojoba wax, Cera Flava, haze tallow Mixture.

Use and above-mentioned further provide the benefit that: above-mentioned palm wax, candelilla wax, Jojoba wax, Cera Flava, haze tallow, for Animal or plant is originated, and is same class material with the wax component in sebum, has plastotype, film forming, water conservation, anti-oxidation, bright Skin and the effect such as hair, enhancing skin barrier.

Further, the one during described lactate is sodium lactate, calcium lactate, zinc lactate, potassium lactate, aluctyl., magnesium lactate Or the most several mixture.

Use and above-mentioned further provide the benefit that: lactate is the natural constituents of human body skin and hair, has uniqueness PH regulator and moisture-keeping functions, make skin be in light moisture state, prevent wrinkle from producing, improve hair quality.

Further, described lipid also includes in cholesteryl ester, phospholipid one or both.Wherein, described cholesteryl ester, Phospholipid is 1:10～10:1 with the weight ratio of triglyceride.

Use and above-mentioned further provide the benefit that: cholesteryl ester and phospholipid are all the Basic Life materials of human body, are also One of component in people's sebum, has soft and moist, gloss, skin nutrition, the anti-ageing effect of waiting for a long time.

Further, the one during described phospholipid is phosphoglyceride, sphingomyelins, soybean lecithin, Ovum Gallus domesticus Flavus lecithin.

Use and above-mentioned further provide the benefit that: phosphoglyceride, sphingomyelins, soybean lecithin, Ovum Gallus domesticus Flavus lecithin are equal Belong to the Life Base material of human body, same or similar with the component in people's sebum, there is soft and moist, gloss, promotion reparation, nutrition The effects such as skin, defying age, lifting skin regeneration vigor, pitch-black hair, suppression alopecia.

Further, described nature moisturizing factor also includes ceramide, hyaluronate sodium, aminoacid, carbamide, allantoin In a kind of or the most several mixture.Wherein, described ceramide, hyaluronate sodium, aminoacid, carbamide, allantoin with Lactated weight ratio is 1:10～10:1.

Use and above-mentioned further provide the benefit that: ceramide, hyaluronate sodium, aminoacid, carbamide are all human body skins Skin and the nature moisturizing factor of hair, have the functions such as the moisturizing of uniqueness, submissive, promotion reparation, make skin be in the most moistening State, prevents wrinkle from producing, defying age.

The two of the purpose of the present invention, are to provide a kind of external preparation containing above-mentioned imitation leather aliphatic radical matter.The external of the present invention Preparation, can as medicine or as cosmetics, have moist, moisturizing, reparation, submissive, soften, anti-ageing basic training effect of waiting for a long time, To Mucocutaneous non-stimulated, safety is high, it is adaptable to the crowd of various age levels.

The technical scheme is that a kind of external system comprising above-mentioned imitation leather aliphatic radical matter Agent, including the constitutive material of following percetage by weight: comprise imitation leather aliphatic radical matter described above 20～90%, natural surfactant 1～20%, natural thickener 0.01～20%, natural antiseptic agent 1～10%, the Natural antioxidant 0.5～10%, natural perfume material Or/and native functional activity thing 0.1～20%.

The external preparation of the present invention, raw material is natural component, can as medicine or as cosmetics, have moist, The effects such as moisturizing, reparation, submissive, softening, defying age, antiinflammatory, to Mucocutaneous non-stimulated, safety is high, it is adaptable to various The crowd of age level.

Further, a kind of or the most several the mixing during described natural surfactant is tea saponin, saponin, alkyl polyglycoside Compound.

Use and above-mentioned further provide the benefit that: natural surfactant is little to the toxicity of skin, and biological degradability is good, Thus avoid using the synthetic surfactant that human body and environment produce bigger harm, drastically increase external system of the present invention The safety of agent.

Further, the weight ratio of described saponin and alkyl polyglycoside is 1:10～10:1, described tea saponin and the weight of saponin Amount ratio is 1:10～10:1, and the weight ratio of described tea saponin and alkyl polyglycoside is 1:10～10:1.

Use and above-mentioned further provide the benefit that: saponin, alkyl polyglycoside, tea saponin are Natural surfactant thing Matter, little to the toxicity of skin, biological degradability is good, but the HLB value having nothing in common with each other, therefore after mixing, there is more preferable emulsification.

Further, described natural thickener is starch, gelatin, sodium alginate, casein, guar gum, Radix Acaciae senegalis, Huang A kind of or the most several mixture in virgin rubber, soybean glue, agar.

Use and above-mentioned further provide the benefit that: natural thickener is little to the toxicity of skin and human body, biological degradability Good, replace the chemosynthesis thickening agent that human body and environment are produced bigger harm, drastically increase external preparation of the present invention Safety.

Further, described xanthan gum is 1:10～10:1 with the weight ratio of other natural thickener.

Use and above-mentioned further provide the benefit that: described natural thickener has different physicochemical properties, Ji Zhongtian So thickening agent mixes, and can reach the thickening effect of different purpose, improve the comfort of product.

Further, the one during described natural antiseptic agent is antibacterial peptide, lysozyme.

Use and above-mentioned further provide the benefit that: chemosynthesis preservative is the main component of external preparation harm skin One of, and natural antiseptic agent is the least to human body and dermal toxicity, and there is the effect such as moisturizing, antiinflammatory, drastically increase this The safety of invention external preparation.

Further, described natural antiseptic agent also includes chitin, chitosan, glycyrrhizin, Chinese juniper oil, catechin, A kind of or the most several mixture in plant extract.Wherein, chitin, chitosan, glycyrrhizin, Chinese juniper oil, catechu Element, the respective weight of plant extract are 0.1～10 times of antibacterial peptide or lysozyme weight.

Use and above-mentioned further provide the benefit that: the antimicrobial spectrum of natural antiseptic agent is different, carry out compounding anti-to improve The coverage of bacterium spectrum, reaches potentiation.

Further, described plant extract is Herba Houttuyniae, Radix Artemisia ordosicae, Aloe, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lignum Sappan, Radix Rubiae, chrysanthemum A kind of or the most several mixture in flower, Radix Arnebiae (Radix Lithospermi), Herba Schizonepetae, Fructus Capsici, Bulbus Allii.

Use and above-mentioned further provide the benefit that: described plant extract is respectively provided with Antimicrobial preservative effect, and with Unlike chemical preservative, it is relatively wide that described plant extract has antimicrobial spectrum, is not likely to produce drug resistance, and the zest to skin The advantage such as less.

Further, the described Natural antioxidant be tea polyphenols, carnosic acid, dilauryl thiodipropionate, vitamin A, A kind of or the most several mixture in vitamin C, vitamin E, tartaric acid.Wherein, described tartaric weight is that tea is many 0.01～1 times of phenol weight, described tea polyphenols, carnosic acid, dilauryl thiodipropionate, vitamin A, vitamin C, dimension are raw The respective weight of element E is 0.01～10 times of tea polyphenols weight.

Use and above-mentioned further provide the benefit that: the Natural antioxidant is to skin and human non-toxic, and has anti-ageing Always, smoothing wrinkle, speckle dispelling, antiinflammatory, effect such as antibacterial.The Natural antioxidant instead of the chemosynthesis to human body and environmental danger Antioxidant, improves the safety of external preparation of the present invention.

Further, the described Natural antioxidant also includes Carthamus yellow, rosmarinic acid, garlic polysaccharide, vitamin A kind of or the most several mixture in P, beta-carotene.Wherein, Carthamus yellow, rosmarinic acid, garlic polysaccharide, dimension life Element P, respective weight is tea polyphenols weight 0.1～10 times of beta-carotene.

Use and above-mentioned further provide the benefit that: Carthamus yellow, rosmarinic acid, garlic polysaccharide, Citrin, β- Carotene is the Natural antioxidant, compounds with other antioxidant, can reach potentiation.

Further, described natural perfume material be Moschus, Zibethum, castoreum, Ambra Grisea, Oleum Terebinthinae, Oleum menthae, citronella oil, A kind of or the most several mixture in tangerine oil, eucalyptus oil, laurel oil, Oleum lavandula angustifolia, Herba Schizonepetae oil, tea tree oil.

Use and above-mentioned further provide the benefit that: chemically composite perfume be external preparation harm skin main component it One, and natural perfume material is the least to human body and dermal toxicity, and there is speckle dispelling, effect of waiting for a long time antibacterial, anti-ageing, drastically increase The safety of external preparation of the present invention and effect.

Further, in the mixture that Oleum lavandula angustifolia is a kind of or the most several with other natural perfume material, other natural perfume (or spice) The respective weight of material is 0.1～10 times of Oleum lavandula angustifolia weight.

Use and above-mentioned further provide the benefit that: Oleum lavandula angustifolia is one of broad-spectrum spice, and fragrance is pure and fresh sweet U.S., is easily in harmonious proportion mutually with other quintessence oils, improves natural perfume material in heat-clearing and toxic substances removing, effect of the aspects such as dispelling wind for relieving itching.

Further, described native functional activity thing be ginsenoside, Radix Glycyrrhizae, Lac regis apis, Aloe gel, Mel, protein, A kind of or the most several mixture in aminoacid, Adeps Serpentis, D-panthenol, a-bisabolol, trehalose, tea tree oil.

Use and above-mentioned further provide the benefit that: native functional activity thing for synthetic drug, to skin and Environmental toxicity is little, has more structurally sound safety in the case of playing certain effect.

Further, described native functional activity thing to be Aloe gel a kind of with other native functional activity thing above-mentioned or The most several mixture.In the mixture that described Aloe gel is a kind of or the most several with other native functional activity thing, It is 0.1～10 times that the respective weight of other component is Aloe gel weight.

Use and above-mentioned further provide the benefit that: Aloe gel has moisturizing, sun-proof, deodorant, preventing obesity, softening skin Skin, anti-inflammatory anti-itch, pain relieving, the effect such as anti-acne, freckle, desalination mottle, extensively, and safety is higher, with other sky in effect So functional activity thing compounds, with potentiation in some given efficacy.

The three of the purpose of the present invention, are to provide the application of above-mentioned external preparation.

The technical scheme is that a kind of external preparation as above is preparing medicine Or the application in cosmetics.

The external preparation of the present invention, can as mucocutaneous external used medicine or as cosmetics, the most mucocutaneous outside Include but not limited to the external preparation dosage forms such as unguentum, patch, liniment, drop, spray, suppository with medicine, cosmetics include but not Be limited to: clean, protect, nutrition, whitening, beautify, anti-ageing skin cosmetic of waiting for a long time；Have one's hair wash, defend the doctrine, haircut, have hair dyed, perm, The hair-dressing cosmetics such as shave；The oral cavity such as toothpaste, Jieyanshuang oral liquor hygienic article；Foundation cream, XIANGFEN, kermes, eyebrow pencil, eye shadow, eyelashes The cosmetics such as oil, mascara, eyeliner, eye-liner, lip pomade, nial polish, fingernail scavenger, perfume；Sun-proof, speckle dispelling, press down The special efficacy cosmetics such as antiperspirant, deodorization, depilation.

The invention has the beneficial effects as follows:

(1) the imitation leather aliphatic radical matter of the present invention, according to bionics principle, chooses and the natural constituents in sebum and skin texture Same or analogous composition, forms the substrate of mucocutaneous external preparation.The imitation leather aliphatic radical matter of the present invention can replace mesh The matrix components being made up of the source such as oil, coal tar chemical raw material in front external preparation, it is to avoid skin is by oil, coal tar Harm Deng source chemical raw material.

(2) the imitation leather aliphatic radical matter of the present invention can be supplemented because excessively cleaning the sebum caused not enough, recovers smegma Function, allows skin recover natural gloss and barrier function, moreover it is possible to promoting that biological active matter and drug osmotic enter internal, performance should have Effect.

(3) the imitation leather aliphatic radical matter of the present invention, can promote that biological active matter and drug osmotic enter internal, play due merit Effect.

(4) external preparation containing above-mentioned imitation leather aliphatic radical matter that the present invention provides, all uses natural origin composition, has The advantage such as, environmental protection non-stimulated to skin, Preservation and therapeutic effect are good.

(5) present invention provide the external preparation containing above-mentioned imitation leather aliphatic radical matter, can as medicine or as cosmetics, It is applicable to the crowd of various age level.

(6) external preparation containing above-mentioned imitation leather aliphatic radical matter that the present invention provides has moist, moisturizing, reparation, submissive, soft Change, anti-ageing effect of waiting for a long time.

(7) external preparation containing above-mentioned imitation leather aliphatic radical matter that the present invention provides, preparation method is simple, and market prospect is wide Wealthy, it is suitable for large-scale production.

Detailed description of the invention

Being described principle and the feature of the present invention below in conjunction with specific embodiment, example is served only for explaining this Bright, it is not intended to limit the scope of the present invention.

Embodiment 1

A kind of imitation leather aliphatic radical matter, including the constitutive material of following weight: water 20kg, lipid 60kg and nature moisturizing factor 20kg, wherein, described lipid be weight ratio be triglyceride and the mixture of lanoline of 10:1, described nature moisturizing factor is Weight ratio is sodium lactate and the mixture of pyrrolidone sodium carboxylate of 10:1.

A kind of external preparation comprising above-mentioned imitation leather aliphatic radical matter, including the constitutive material of following weight: imitation leather aliphatic radical matter 20kg, natural surfactant 20kg, natural thickener 20kg, natural antiseptic agent 10kg, Natural antioxidant 10kg, natural perfume (or spice) Material 2kg, natural active matter 18kg, wherein, described natural surfactant is tea saponin, and described natural thickener is starch, The described Natural antioxidant be weight ratio be the tea polyphenols of 10:0.1:0.1:0.1:0.1:0.1:0.1, carnosic acid, sulfur generation two Propanoic acid dilauryl, vitamin A, vitamin C, vitamin E, tartaric acid.Described natural antiseptic agent is antibacterial peptide, described natural perfume (or spice) Material is Essential lavender oil, and natural active matter is Lac regis apis.

A kind of as above external preparation can be as cosmetics, for Mucocutaneous daily nursing, have moisturizing, Skin moistening, reparation, effect of waiting for a long time sun-proof, anti-ageing, can be as medicine, for dermal inflammatory disease and skin pruritus, as eczema, The treatment of allergic dermatitis, insect bite dermatitis, skin pruritus etc..

Embodiment 2

A kind of imitation leather aliphatic radical matter, including the constitutive material of following weight: water 50kg, lipid 40kg and nature moisturizing factor 10kg, wherein, described lipid be weight ratio be the triglyceride of 1:10:10:10:10:10, Jojoba oil, Squalene, waxiness, Cholesteryl ester, the mixture of soybean lecithin, described nature moisturizing factor is the sodium lactate of weight ratio 1:1:1, ketopyrrolidine carboxylic Acid sodium and the mixture of ceramide.

A kind of external preparation comprising above-mentioned imitation leather aliphatic radical matter, including the constitutive material of following weight: imitation leather aliphatic radical matter 60kg, natural surfactant 10kg, natural thickener 10kg, natural antiseptic agent 5kg, Natural antioxidant 5kg, natural perfume material 5kg, natural active matter 5kg, wherein, described natural surfactant is saponin and the mixing of alkyl polyglycoside of weight ratio 10:1 Thing, described natural thickener is xanthan gum and the mixture of gelatin of weight ratio 10:1, and the described Natural antioxidant is weight ratio Raw for the tea polyphenols of 1:1:1:1:1:1:1:0.1, carnosic acid, dilauryl thiodipropionate, vitamin A, vitamin C, dimension Element E, tartaric acid, the mixture of Citrin, described natural antiseptic agent is the lysozyme of weight ratio 1:0.1:0.1:0.1:0.1, shell Polysaccharide, sitosterol, glycyrrhizin, the mixture of catechin, described natural perfume material be weight ratio 10:1:1 for Oleum lavandula angustifolia, osmanthus Caul-fat, the mixture of Herba Schizonepetae oil, described natural active matter be weight ratio 1:0.1:0.1:0.1 for Aloe gel, Radix Ginseng soap Glycosides, Lac regis apis, the mixture of Adeps Serpentis

A kind of as above external preparation can be as cosmetics, for Mucocutaneous daily nursing, have moisturizing, The effect such as skin moistening, reparation, sun-proof, defying age, smoothing wrinkle, can be as medicine, for mucocutaneous infections, skin pruritus, skin The treatment of the diseases such as mucosal ulcer, allergic dermatitis, insect bite dermatitis.

Embodiment 3

A kind of imitation leather aliphatic radical matter, including the constitutive material of following weight: water 80kg, lipid 1kg and nature moisturizing factor 19kg, wherein, described lipid be weight ratio be the triglyceride of 1:1:1:1:1, olive oil, Squalene, waxiness, soybean lecithin Mixture, described nature moisturizing factor be the sodium lactate of weight ratio 1:10:0.1:10, pyrrolidone sodium carboxylate, hyaluronic acid, The mixture of allantoin.

A kind of external preparation comprising above-mentioned imitation leather aliphatic radical matter, including the constitutive material of following weight: imitation leather aliphatic radical matter 90kg, natural surfactant 1kg, natural thickener 0.01kg, natural antiseptic agent 1kg, Natural antioxidant 0.5kg, natural Active substance 7.49kg, wherein, described natural surfactant is alkyl polyglycoside and the mixture of tea saponin of weight ratio 10:1, Described natural thickener is xanthan gum and the mixture of melon glue of weight ratio 1:10, and the described Natural antioxidant is that weight ratio is The tea polyphenols of 1:10:10:10:10:10:1:10, carnosic acid, dilauryl thiodipropionate, vitamin A, vitamin C, dimension Raw element E, tartaric acid, the mixture of Carthamus yellow, described natural antiseptic agent is that the lysozyme of weight ratio 1:10:10:10, shell gather Sugar, sitosterol, the mixture of catechin, described natural active matter is the Aloe gel of weight ratio 1:10:10, aminoacid, silk The mixture of peptide protein.

A kind of external preparation as above can prepare medicine as shower class, hair care category, skin cleaning class cosmetics Or the application in cosmetics, for skin and the daily nursing of hair, there is moisturizing, skin moistening, reparation, submissive, defying age, smoothing wrinkle Etc. effect, can be as medicine, for diseases such as mucocutaneous infections, skin pruritus, mucocutaneous ulcer, insect bite dermatitis Treatment.

Embodiment 4

A kind of imitation leather aliphatic radical matter, including the constitutive material of following weight: water 54kg, lipid 26kg and nature moisturizing factor 20kg.Wherein, described lipid be weight ratio be the triglyceride of 5:5:2:0.5:1:1:1:1, Adeps Bovis seu Bubali resin, cera alba, Flos Camelliae Japonicae Seed oil, phosphoglyceride, stearic acid, cholesteryl ester, the mixture of Squalene, described nature moisturizing factor be weight ratio be 5:3:1: The sodium lactate of 1:2, pyrrolidone sodium carboxylate, carbamide, hyaluronate sodium, the mixture of valine.

A kind of mucocutaneous nursing cream comprising above-mentioned imitation leather aliphatic radical matter, including the constitutive material of following weight: imitation leather fat Substrate 75kg, natural surfactant 3kg, natural thickener 1.3kg, natural antiseptic agent 8.2kg, Natural antioxidant 3kg, sky So spice 1kg, natural active matter 8.5kg, wherein, described natural surfactant is alkyl polyglycoside, described natural thickener For xanthan gum and the mixture of sodium alginate of weight ratio 3:1, the described Natural antioxidant be weight ratio be 5:1:1:1:1:1: The tea polyphenols of 0.1:2, carnosic acid, dilauryl thiodipropionate, vitamin A, vitamin C, vitamin E, tartaric acid, fan are repeatedly The mixture of fragrant acid, described natural antiseptic agent is the lysozyme of weight ratio 10:1:1, water-soluble chitosan, the mixing of b-sitosterol Thing, described natural active matter is the aloe vera gel of weight ratio 1:1:1:1:1:1:1:1, Adeps Serpentis, glycyrrhizic acid, queen bee Slurry, D-panthenol, a-bisabolol, trehalose, the mixture of silk peptide albumen, described natural perfume material is the lavandula angustifolia of weight ratio 1:1 Oil and the mixture of Australia tea tree oil.

A kind of mucocutaneous nursing cream as above have moist, moisturizing, reparation, submissive, soften, crease-resistant, except speckle, anti- The effects such as aging, antiallergic, antiinflammatory, raising skin barrier function, can be used for the various abnormal skin of each age level crowd Nursing, including: insect bite dermatitis, mucocutaneous ulcer, various eczema, epidermis injury, allergic dermatitis etc., it is also possible to for just The often daily nursing of skin.

Embodiment 5

A kind of imitation leather aliphatic radical matter, including the constitutive material of following weight: water 61kg, lipid 22kg and nature moisturizing factor 17kg.Wherein, described lipid be weight ratio be the triglyceride of 3:3:1:1:1:1, almond oil, Squalene, cera alba, Semen sojae atricolor ovum Phospholipid, the mixture of cholesteryl ester, described nature moisturizing factor be weight ratio be the sodium lactate of 3:1:1:0.5, ketopyrrolidine carboxylic Acid sodium, ceramide, the mixture of allantoin.

A kind of mucocutaneous moist cream comprising above-mentioned imitation leather aliphatic radical matter, including the constitutive material of following weight: imitation leather fat Substrate 88kg, natural surfactant 3kg, natural thickener 1.6kg, natural antiseptic agent 5.2kg, Natural antioxidant 1.2kg, Natural perfume material 1.0kg, wherein, described natural surfactant is alkyl polyglucoside, and described natural thickener is the Huang of weight ratio 1:1 Virgin rubber and the mixture of gelatin, the described Natural antioxidant be weight ratio be the tea polyphenols of 1:1:1:1:1:1:0.1, Salvia japonica Thunb. Acid, dilauryl thiodipropionate, vitamin A, vitamin C, vitamin E, tartaric mixture, described natural antiseptic agent is The lysozyme of weight ratio 1:1:1, Herba Houttuyniae extract, the mixture of luxuriant growth pitch, described natural perfume material is smoking of weight ratio 1:10 Clothing grass oil and the mixture of laurel oil.

This mucocutaneous moist cream have moist, moisturizing, reparation, submissive, soften, crease-resistant, except speckle, defying age, antiallergic, The effects such as antiinflammatory, raising skin barrier function, can be used for the Mucocutaneous nursing of each age level crowd, including: desquamative Dermatitis, allergic dermatitis, xerosis cutis, sebum secretion dysfunction etc., it is also possible to for dry, cold district resident just The often daily nursing of skin.

Embodiment 6

A kind of imitation leather aliphatic radical matter, including the constitutive material of following weight: water 50kg, lipid 45kg and nature moisturizing factor 5kg.Wherein, described lipid be weight ratio be the triglyceride of 1:1:10:1:2:3:10, Adeps Bovis seu Bubali resin, Oleum Gossypii semen, Squalene, Palm wax, phosphoglyceride, the mixture of cholesteryl ester, described nature moisturizing factor be weight ratio be 3:1: sodium lactate and pyrroles The mixture of alkanone carboxylic acid sodium.

A kind of antiallergic and antipruritic ointment comprising above-mentioned imitation leather aliphatic radical matter, including the constitutive material of following weight: imitation leather fat Substrate 80kg, natural surfactant 3kg, natural thickener 5kg, natural antiseptic agent 10kg, Natural antioxidant 2.5kg, sky So active substance 5.5kg, wherein, described natural surfactant is alkyl polysaccharide, and natural thickener is xanthan gum, described natural Antioxidant be weight ratio be the tea polyphenols of 3:2:1:1:10:5:0.1, carnosic acid, dilauryl thiodipropionate, vitamin A, vitamin C, vitamin E, tartaric mixture, described natural antiseptic agent is antibacterial peptide, and described natural active matter is sweet Oxalic acid.

The antipruritic ointment of this allergy has antiinflammatory, antiallergic, moisturizing, reparation, anti-ageing effect of waiting for a long time, and can be used for anaphylaxis skin The treatment of the dermatosis such as inflammation, skin infection, skin pruritus.

Embodiment 7

A kind of imitation leather aliphatic radical matter, including the constitutive material of following weight: water 70kg, lipid 20kg and nature moisturizing factor 10kg.Wherein, described lipid be weight ratio be 2:2:2:2:1:1:1 triglyceride, Adeps Bovis seu Bubali resin, Camellia oil, Semen sojae atricolor ovum phosphorus Fat, stearic acid, cholesteryl ester, the mixture of Squalene, described nature moisturizing factor be weight ratio be sodium lactate and the pyrroles of 1:1 The mixture of alkanone carboxylic acid sodium.

A kind of dandruff hair care water comprising above-mentioned imitation leather aliphatic radical matter, including the constitutive material of following weight: imitation leather fat Substrate 60kg, natural surfactant 18.5kg, natural thickener 0.5kg, natural antiseptic agent 5kg, Natural antioxidant 2kg, Natural perfume material 5kg, natural active matter 9kg, wherein, described natural table activating agent be weight ratio be tea saponin and the alkyl of 10:1 The mixture of glucosides, described natural thickener is xanthan gum, the described Natural antioxidant be weight ratio be 8:2:1:1:10:5: The tea polyphenols of 0.1, carnosic acid, dilauryl thiodipropionate, vitamin A, vitamin C, vitamin E, tartaric mixing Thing, described natural antiseptic agent is lysozyme and the mixture of cupreol of weight ratio 10:1, and described natural perfume material is weight ratio For Oleum lavandula angustifolia and the mixture of Oleum menthae of 5:2, described natural active matter is the Aloe gel of weight ratio 5:2:1:1, sweet Oxalic acid, allantoin, the mixture of trehalose.

This dandruff hair care water have moist, moisturizing, reparation, submissive, soften, pitch-black, dandruff, prevent hair from dividing The effects such as fork, can be used for the hair nursing of each age level crowd.

Experimental example:

1, by embodiment 4 gained unguentum, carry out physical and chemical index, noxious substance limitation, Micro biological Tests, the results are shown in Table 1-3.

Table 1 physical and chemical index

Table 2 noxious substance is limited the quantity

Table 3 microbial check

2, toxicology test

(1) by made for embodiment 4 unguentum, according to " cosmetics safety technical specification " (version in 2015), acute ocular thorn is carried out Swash property test

1. material: select 3 adult regular grade new zealand rabbits, Medical University Of Chongqing's Experimental Animal Center provide.Single cage Raise, feed of freely drinking water, laboratory temperature: 15～25 DEG C, relative humidity: 40～70%RH.The made unguentum of Example 1 10g, takes filtrate after 10mL normal saline dilution.

2. test method:

Eyes inspection in 24h before test: with the hands thumb and forefinger pull open the palpebra inferior of rabbit gently, drip to animal conjunctival sac Enter the fluorescein sodium diluent 2 of 2%, make upper and lower eyelid passively close about 1s and prevent medicinal liquid from flowing out, then unclamp both hands, appoint Its Natural closure.Slowly rinse with pure water after 30s, the fluorescein sodium in eyes is rinsed well, observe after 1 hour, have no Animal eyes occurs that the monthly damage of irritation, corneal defect and knot, 3 rabbits are completely used for test.

Contamination method: with the hands thumb and forefinger pull open the palpebra inferior of eyes on the right side of rabbit gently, by every 0.1mL, will be real The filtrate executing example 1 gained unguentum is directly painted in the conjunctival sac that New Zealand exempts from dimsight eye, makes upper and lower eyelid passively close about 1s and prevents Only it flows out, and does not rinse eyes after being painted into tested material in 24h.Left side eyes do not process makees own control.24h instills after observing 2% fluorescein sodium diluent, cleans up after 30s.

Clinical examination and scoring: after being painted into tested material, animal eyes is entered by 1h, 24h, 48h, 72h and 4d and 7d Row checks.If 72h does not occurs irritating reaction, get final product termination test.If it find that involve cornea or have other Eye irritation effect, Not recuperator in 7d, need to extend observing time for the reversibility or irreversibility determining this infringement, be usually no more than 21d, and carry Visual report for 7d, 14d, 21d.In addition to corneal, iris, conjunctiva are observed, other detrimental effect is all recorded faithfully. All should be by<cosmetics safety technical specification>(version in 2015), acute ocular zest/corrosion test table 1 in checking every time The integration of " standards of grading of eye infringement " record Eye irritation reaction.

Evaluation of result: to observe time point to animal corneal, iris or conjunctiva after tested material each comfortable 24h, 48h or 72h Eye swashs the top of reaction and evaluates recovery time, and by<cosmetics safety technical specification>(version in 2015), acute ocular stimulates Property/corrosion test table 3 " eye excitatory reaction classification " the judgement tested material stimulus intensity to eye.The results are shown in Table 4.

Table 4 tested material experiment excitatory to rabbit acute ocular appraisal result (experiment condition: do not rinse)

(2) the embodiment 4 made unguentum acute toxicity testing to rabbit

1. material: the white family of body weight 2.0～2.5kg exempts from, male and female half and half are carried by Medical University Of Chongqing's animal experimental center For providing.Use the made unguentum of embodiment 4.

2. test method: take healthy white rabbit 16, body weight 2.0～2.5kg, male and female half and half.With depilatory, man is exempted from The hair of both sides, back is sloughed, and every lateral area is 1.0 × 1.5cm², check skin after unhairing, have damage is divided into damaged skin group. Rabbit is randomly divided into 4 groups, intact skin group, damaged skin group, normal saline integrity degree skin group, normal saline damaged skin Group, often group 4.The scratch of damaged skin group rabbit skin 400# sand paper is had oozing of blood to wound surface, give embodiment 1 respectively Made unguentum and normal saline, dosage 4g/kg, 1 day 3 times, wraps up with gauze.Remaining medicine, observer is washed away with warm water after 24h Rabbit skin conditions, and continuous 1 week of the change such as diet, defecation, activity, body weight.After observing 1 week, vivisection, see the heart, liver, Kidney is with or without ANOMALOUS VARIATIONS.

3. result: administration group compares with normal saline group without significant difference, and more complete group of damaged skin group rabbit skin is red, Having no edema, downright bad, each group man exempts to be showed no toxic reaction, and the heart, liver, kidney have no different.

(3) the embodiment 4 made unguentum long term toxicity test (oral experiment) to SD rat

1. material: SD rat, 16, male and female half and half, Medical University Of Chongqing's animal experimental center provide.

2. method: SD rat 16, is randomly divided into two groups, and experimental group gavage gives embodiment 1 made unguentum 1g/kg/ days, Dividing and sooner or later pour into for twice, matched group gavage gives normal saline, successive administration 1 month, observes Mus diet, defecation, work The situation of change such as dynamic, vivisection, observe liver, kidney with or without ANOMALOUS VARIATIONS.

3. result: experimental group compares without significant difference with matched group, each group Mus is showed no toxic reaction, and the heart, liver, kidney have no Different.

3, effect assessment

(1) antiphlogistic effects of white mice auricle edema caused by embodiment 4 made unguentum xylol

1. material: Kun Ming mice, body weight 20～25g, male and female half and half, Medical University Of Chongqing's animal experimental center carry Supply；Piyanping ointment is three nine-day periods after the winter solstice enterprise group's production；Dimethylbenzene (analytical pure) is produced by Beijing Chemical Plant.

2. method: white mice 30 is only randomly divided into 3 groups: test group, Piyanping ointment group, normal saline group, gives respectively The made unguentum of embodiment 1, Piyanping ointment and normal saline, dosage is 0.lg/, is coated in mouse right ear two sides.It is administered After 30min, only causing to swell then at mouse right ear two topcoating dimethylbenzene 0.lmL/, left ear is not painted with normal ear.After 1h, de-cervical vertebra is put to death Mice, sweeps away the disk at the same position of left and right ear with 6mL card punch, weighing on torsion power balance, and auris dextra weight deducts left ear Weight is swelling, the antiinflammatory action of relatively more each group.

3. result: as shown in Table 5, the made unguentum of embodiment 1 can be readily apparent that to suppress the auricle of caused by dimethylbenzene xylene white mice Swelling, its swelling is significantly lower than normal saline group.

The made unguentum xylol of table 5 embodiment 4 causes the impact ((X ± S, n=10)) of white mice auricle edema

Note: compare with normal saline group: * P < 0.01, * * P < 0.001

(2) the made unguentum of embodiment 4 improves the microcirculatory experiment of Mice Auricle

1. material: Kun Ming mice, body weight 20～25g, male and female half and half, Medical University Of Chongqing's animal experimental center carry Supply；Radix Salviae Miltiorrhizae Injection is that Yaan three nine-day periods after the winter solstice Pharmaceutical produces；Dimethylbenzene (analytical pure) is produced by Beijing Chemical Plant.

2. white mice 30 is only randomly divided into 3 groups, intramuscular injection 20% urethane solution 0.7mL/100g, after anesthesia, with doctor Gently paste auricle with rubber, pull out Mus hair, mouse web portion is downwardly fixed to mice observation platform, the ear that regulation is made with lucite Torr height, makes auricle open and flat in earpiece, is placed on microscope carrier by observation platform, regulates the suitable brightness of cold light source, thoroughly Penetrate under light, with 80 times of sem observation Mice Auricle microcirculations before administration after change, experimental group and normal saline group are respectively at ear The wide made unguentum of coating Examples 1 and normal saline (0.1g/ is only), Radix Salviae Miltiorrhizae Injection group lumbar injection Radix Salviae Miltiorrhizae Injection (100mg/ is only), 30min auricular microcirculation arteriole, thin vein, external caliber, blood flow rate after record administration, micro-to judge Circulation improvement situation.

3. result: result shows, compared with normal saline group, auricle arteriole after experimental group and the administration of Radix Salviae Miltiorrhizae group mice There is significant difference with thin vein external caliber increase value, blood flow rate is substantially accelerated.

4, the moistening effect evaluation of the made unguentum of embodiment 4

(1) some pieces of the clean glass plate of material: 7.5 × 7.5cm, 3M adhesive plaster.Reference substance is that POKO baby's baby water profit is protected Skin frost.

(2) experimental technique: weigh 6 pieces of glass plate weight (M posting 3M adhesive plaster₀), record respectively, 3 pieces is blank, 3 pieces is sampling test.Take 0.2g sample to be added on the glass plate posting 3M adhesive plaster, weigh this weight M with analytical balance₁(accurately To 0.000lg), sample is smoothened, glass plate is put into dry behaviour's device of constant humidity (60%).By remaining 3 pieces of blank glass Glass plate is put in the exsiccator of constant humidity together.After placing 4h, 8h, take out glass plate, weigh this glass plate weight (M₂), survey Try its moisturizing rate and relative humidity rate, be immediately placed in the exsiccator of constant humidity after weighing.

Moisturizing rate computing formula: moisturizing rate=(M₂-M₀)/(M₁-M₀) × 100%

(3) experimental result (table 6): as shown in Table 6, the moistening effect in short-term of the made unguentum of embodiment 1 and long-acting moisturizing effect Fruit is with POKO baby skin protection frost quite.

The made unguentum of table 6 embodiment 4 and POKO reference substance are in the moisturizing rate of RH60%

5, clinical trial result

(1) collect voluntary trier 155 people by the Internet, issue one, embodiment 1 made unguentum sample simultaneously and adjust Table look-up portion, it is desirable to made for embodiment 1 unguentum sample, with behind clean water affected part, is applied to affected part by experimenter, three times a day, 1 1 week course for the treatment of.Regain application form after one week, carry out data statistics analyse.

(2) live data 137 parts, wherein baby trier (0-3 year) 85 parts, wherein eczema 55 people, insect bite skin are reclaimed altogether Scorching 30 people；Middle age group (3-60 year) 40 people, eczema 32 people, insect dermatitis 8 people；And group (more than 60 years old) 12 people in old age, eczema 11 People, xerosis cutis 1 people.

(3) effect criterion:

Recovery from illness: skin lesion all disappears, pruritis disappears, and curative effect rate reaches 100%；

Effective: skin lesion substantially disappears or major part disappears, and pruritus substantially alleviates, curative effect rate reaches more than 70%；

Effective: skin lesion partial remission, pruritis makes moderate progress, and curative effect rate reaches more than 30%；

Invalid: skin lesion disappears inconspicuous, pruritus has no and alleviates or clinical symptoms deterioration, and curative effect rate does not reaches 30%.

Curative effect rate: curative effect rate=(total mark after total mark-treatment before treating)/treat front total mark × 100%

(4) result (table 7): as shown in Table 7, in 136 example triers, invalid only 9 examples, total effective rate 93.4%, Ying Ershi User's total effective rate is 100%, and old eczema patients effective percentage is relatively low is 66.6%.Eczema trier's effective percentage is 92.6%, Insect dermatitis trier's effective percentage is 95.12%.

Table 7 each subject effect (example)

Toxicology test, pharmacodynamics test and clinical trial result prove, imitation leather fat matrix formulations reasonable recipe of the present invention, Feasible process, safety non-toxic, without skin hypersensitivity, to the inhibitory action of mice auricle swelling degree clearly, and have significantly Improve the microcirculatory effect of Mice Auricle, to animal normal skin and damaged skin nonirritant, have the most antipruritic, antiinflammatory, guarantor Wet, repair, can be used for the nursing of the various abnormal skin of each age level crowd, including: insect bite dermatitis, mucocutaneous Ulcer, various eczema, epidermis injury, allergic dermatitis etc., it is also possible to for the daily nursing of normal skin.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims

1. the imitation leather aliphatic radical matter of an external preparation, it is characterised in that include the constitutive material of following percetage by weight: lipid 1 ～60%, nature moisturizing factor 0.5～20% and water 20～80%, wherein, described lipid be triglyceride, animal oil or/and Mixture a kind of or the most several in vegetable oil, Squalene, waxiness, described nature moisturizing factor be pyrrolidone sodium carboxylate and Lactated mixture.

The imitation leather aliphatic radical matter of a kind of external preparation the most according to claim 1, it is characterised in that described animal oil is Pilus Caprae seu Ovis A kind of or the most several mixture in fat, lanolin derivative, stearic acid, described vegetable oil is olive oil, soybean oil, tea A kind of or the most several in seed oil, almond oil, Jojoba oil, Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, American Avocado Tree oil, Camellia oil, Adeps Bovis seu Bubali resin Mixture.

The imitation leather aliphatic radical matter of a kind of external preparation the most according to claim 1, it is characterised in that described waxiness is Petiolus Trachycarpi A kind of or the most several mixture in wax, candelilla wax, Jojoba wax, Cera Flava, haze tallow, described lactate be sodium lactate, A kind of or the most several mixture in calcium lactate, zinc lactate, potassium lactate, aluctyl., magnesium lactate.

4. according to the imitation leather aliphatic radical matter of a kind of external preparation described in any one of claim 1-3, it is characterised in that described lipid In also include in cholesteryl ester, phospholipid one or both, described nature moisturizing factor also includes ceramide, hyaluronic acid A kind of or the most several mixture in sodium, aminoacid, carbamide, allantoin.

5. the external preparation of an imitation leather aliphatic radical matter, it is characterised in that include the constitutive material of following percetage by weight: comprise power Profit require described in any one of 1-3 imitation leather aliphatic radical matter 20～90%, natural surfactant 1～20%, natural thickener 0.01～ 20%, natural antiseptic agent 1～10%, the Natural antioxidant 0.5～10%, natural perfume material or/and native functional activity thing 0.1～ 20%.

External preparation the most according to claim 5, it is characterised in that described natural surfactant be tea saponin, saponin, A kind of or the most several mixture in alkyl polyglycoside；Described natural thickener be starch, gelatin, sodium alginate, casein, A kind of or the most several mixture in guar gum, Radix Acaciae senegalis, xanthan gum, soybean glue, agar；Described natural anti- Rotten agent is the one in antibacterial peptide, lysozyme；The described Natural antioxidant is tea polyphenols, carnosic acid, thiodipropionic acid dilauryl A kind of or the most several mixture in osmanthus ester, vitamin A, vitamin C, vitamin E, tartaric acid；Described natural perfume material is Moschus, Zibethum, castoreum, Ambra Grisea, Oleum Terebinthinae, Oleum menthae, citronella oil, tangerine oil, eucalyptus oil, laurel oil, Oleum lavandula angustifolia, A kind of or the most several mixture in Herba Schizonepetae oil, tea tree oil.

External preparation the most according to claim 6, it is characterised in that also include Flos Carthami yellow in the described Natural antioxidant A kind of or the most several mixture in element, rosmarinic acid, garlic polysaccharide, Citrin, beta-carotene.

External preparation the most according to claim 6, it is characterised in that also include chitin, shell in described natural antiseptic agent A kind of or the most several mixture in polysaccharide, glycyrrhizin, Chinese juniper oil, catechin, plant extract.

External preparation the most according to claim 5, it is characterised in that described native functional activity thing is ginsenoside, sweet In grass, Lac regis apis, Aloe gel, Mel, protein, aminoacid, Adeps Serpentis, D-panthenol, a-bisabolol, trehalose, tea tree oil A kind of or the most several mixture.

10. the external preparation as described in any one of the claim 5-9 application in preparing medicine or cosmetics.