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CN105878104B - A kind of disposable low bubble bath product and preparation method thereof being used for space or submersible environment - Google Patents

A kind of disposable low bubble bath product and preparation method thereof being used for space or submersible environment Download PDF

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CN105878104B
CN105878104B CN201610217877.5A CN201610217877A CN105878104B CN 105878104 B CN105878104 B CN 105878104B CN 201610217877 A CN201610217877 A CN 201610217877A CN 105878104 B CN105878104 B CN 105878104B
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space
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bath
matrine
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CN105878104A (en
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卢卫红
周英钰
董青青
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Harbin Institute of Technology Shenzhen
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair

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Abstract

A kind of disposable low bubble bath product and preparation method thereof being used for space or submersible environment.The present invention relates to a kind of low bubble bath products and preparation method thereof.The invention aims to solve the problem of that the bath product for being currently used for staff on space station and submarine is easy that red swelling of the skin is made to cause damage.Product of the present invention is prepared by sodium lauroyl glutamate, positive decyl glucoside, lecithin, xanthans, glycerine, Aloe Vera Gel, matrine, climbazole, vitamin, wheat-germ oil, sodium chloride and citric acid.Method:One, raw material is weighed;Two, sodium lauroyl glutamate, positive decyl glucoside, lecithin and xanthans are uniformly mixed under heating water bath, then homogeneous in homogenizer is gone to, it goes in water-bath again, glycerine, Aloe Vera Gel, matrine, climbazole, vitamin E and wheat-germ oil is added, it is stirring evenly and then adding into sodium chloride regulation system viscosity, lemon acid pH is added;Three, it is sealed and is packed with aluminium foil.

Description

一种用于空间或潜水环境的免洗低泡沐浴产品及其制备方法A kind of disposable low-foam bath product for space or diving environment and preparation method thereof

技术领域technical field

本发明涉及一种低泡沐浴产品及其制备方法。The invention relates to a low foam bath product and a preparation method thereof.

背景技术Background technique

长期在空间站工作的宇航员处于失重条件下,在地面上简单的洗浴问题也成为了空间站上的巨大挑战。在潜水艇工作的海员,也面临着淡水缺乏的问题。如果过长时间不洗澡的话,身上会产生异味,由于座舱空间狭小,长此以往会影响心理健康,甚至会伴有焦虑、烦躁、抑郁等精神疾患。Astronauts who have worked on the space station for a long time are under weightless conditions, and the simple problem of bathing on the ground has also become a huge challenge on the space station. Seafarers working in submarines also face the problem of lack of fresh water. If you don’t take a shower for a long time, you will have peculiar smell on your body. Due to the small space in the cockpit, it will affect your mental health in the long run, and even be accompanied by mental disorders such as anxiety, irritability, and depression.

目前,解决这类问题的方法是使用浸有清洁剂的湿毛巾擦拭,但此种方法的容易使皮肤红肿,造成损伤,舒适度略低,费时费力。而市场上生产的沐浴露又无法达到应用于航天环境的严格标准,所以急需一种既符合空间站座舱工作需求,又性质稳定、无毒无味、泡沫细腻、量少易冲洗,可用于洗脸、洗头及洗浴三合一的低泡沐浴产品。At present, the method to solve this kind of problem is to use a wet towel soaked in detergent to wipe, but this method is easy to make the skin red and swollen, causing damage, the comfort is slightly low, and it is time-consuming and laborious. However, the shower gels produced on the market cannot meet the strict standards used in the aerospace environment, so there is an urgent need for a shower gel that meets the work requirements of the space station cockpit, is stable in nature, non-toxic and tasteless, has fine foam, and is easy to rinse with a small amount. It can be used for face washing, washing A three-in-one low-foaming bath product for hair and bath.

发明内容Contents of the invention

本发明目的是为了解决现有用于空间站和潜水艇上工作人员的沐浴产品容易使皮肤红肿,造成损伤的问题,而提供一种用于空间或潜水环境的免洗低泡沐浴产品及其制备方法。The purpose of the present invention is to solve the problem that the existing bath products used for workers on space stations and submarines tend to cause redness and swelling of the skin and cause damage, and provide a non-washing low-foam bath product for space or diving environments and its preparation method .

本发明的一种用于空间或潜水环境的免洗低泡沐浴产品按质量份数由180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、10~15份黄原胶、60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素、1~2份小麦胚芽油、氯化钠和柠檬酸制备而成;其中氯化钠的量为使体系在室温下黏度为4000mPa·s,柠檬酸的量为使体系pH值为6~7。A disposable low-foaming bath product for space or diving environment of the present invention consists of 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, and 40-50 parts of lecithin , 10-15 parts of xanthan gum, 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanola, 1-2 parts of vitamins, 1-2 parts of wheat germ oil, Prepared from sodium chloride and citric acid; wherein the amount of sodium chloride is such that the viscosity of the system at room temperature is 4000mPa·s, and the amount of citric acid is such that the pH of the system is 6-7.

本发明的一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法按以下步骤进行:A kind of preparation method of the disposable low-foaming bath product that is used in space or diving environment of the present invention is carried out according to the following steps:

一、按质量份数称取180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、10~15份黄原胶、60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素E和1~2份小麦胚芽油,备用;1. Weigh 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, 40-50 parts of lecithin, 10-15 parts of xanthan gum, 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanolin, 1-2 parts of vitamin E and 1-2 parts of wheat germ oil, set aside;

二、将180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、和10~15份黄原胶加入到反应容器中,然后将反应容器置于水浴中,由室温加热至温度为70~80℃,并在温度为70~80℃和搅拌速度为1500r/min~2000r/min的条件下搅拌15min~25min,然后转至均质机中进行均质混匀,均质时间为8min~12min,得到均质后混合物,将水浴温度由70~80℃降至温度为50~60℃,然后将均质后的混合物转至水浴中,再加入60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素E和1~2份小麦胚芽油,在温度为50~60℃和搅拌速度为1500r/min~2000r/min的条件下搅拌均匀,得到组合物,然后加入氯化钠调节体系黏度至组合物在室温下的黏度为4000mPa·s,最后加入柠檬酸调节体系pH值至6~7,得到产品组合物;2. Add 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, 40-50 parts of lecithin, and 10-15 parts of xanthan gum into the reaction vessel, and then place the reaction vessel In a water bath, heat from room temperature to a temperature of 70-80°C, and stir for 15min-25min at a temperature of 70-80°C and a stirring speed of 1500r/min-2000r/min, then transfer to a homogenizer for Homogeneous mixing, the homogenization time is 8min~12min, to obtain the homogenized mixture, lower the temperature of the water bath from 70~80℃ to 50~60℃, then transfer the homogenized mixture to the water bath, and then add 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanolin, 1-2 parts of vitamin E and 1-2 parts of wheat germ oil, at a temperature of 50-60 ° C and Stir evenly at a stirring speed of 1500r/min to 2000r/min to obtain a composition, then add sodium chloride to adjust the viscosity of the system until the viscosity of the composition at room temperature is 4000mPa·s, and finally add citric acid to adjust the pH value of the system to 6~7, obtain product composition;

三、用铝箔对步骤二得到的产品组合物进行密封包装,得到用于空间或潜水环境的免洗低泡沐浴产品。3. The product composition obtained in step 2 is sealed and packaged with aluminum foil to obtain a non-cleaning low-foaming bath product for space or diving environment.

本发明的有益效果:Beneficial effects of the present invention:

本发明制备方法简单易操作,原料易得,成本低,提供了一种性质稳定、无毒无味、低泡、具有清洁能力、符合航天环境要求且适用于空间站的免洗低泡沐浴产品,是集洗脸、洗头和洗浴为一体的三合一的免洗低泡沐浴产品。The preparation method of the present invention is simple and easy to operate, the raw materials are easy to obtain, and the cost is low. It provides a non-cleaning low-foaming bath product that is stable in nature, non-toxic, tasteless, low-foaming, has cleaning ability, meets the requirements of the aerospace environment, and is suitable for space stations. It is a three-in-one non-rinsing low-foaming bath product that integrates face washing, hair washing and bathing.

具体实施方式Detailed ways

具体实施方式一:本实施方式的一种用于空间或潜水环境的免洗低泡沐浴产品按质量份数由180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、10~15份黄原胶、60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素、1~2份小麦胚芽油、氯化钠和柠檬酸制备而成;其中氯化钠的量为使体系在室温下黏度为4000mPa·s,柠檬酸的量为使体系pH值为6~7。Specific embodiment one: A kind of disposable low-foaming bath product used in space or diving environment according to the present embodiment consists of 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, 40-50 parts of lecithin, 10-15 parts of xanthan gum, 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanol, 1-2 parts of vitamins, 1-2 parts of Prepared from 2 parts of wheat germ oil, sodium chloride and citric acid; wherein the amount of sodium chloride is such that the viscosity of the system at room temperature is 4000mPa·s, and the amount of citric acid is such that the pH of the system is 6-7.

具体实施方式二:本实施方式与具体实施方式一不同的是:所述的用于空间或潜水环境的免洗低泡沐浴产品按质量份数由200份月桂酰谷氨酸钠、200份正癸基葡萄糖苷、50份卵磷脂、14份黄原胶、80份甘油、100份芦荟胶、100份氯化钠、2份苦参碱、1份甘宝素、1份维生素、1份小麦胚芽油、氯化钠和柠檬酸制备而成;其中氯化钠的量为使体系在室温下黏度为4000mPa·s,柠檬酸的量为使体系pH值为7。其他步骤及参数与具体实施方式一相同。Specific embodiment two: the difference between this embodiment and specific embodiment one is: the described disposable low-foaming bath product for space or diving environment consists of 200 parts by mass of sodium lauroyl glutamate, 200 parts of normal Decyl Glucoside, 50 parts Lecithin, 14 parts Xanthan Gum, 80 parts Glycerin, 100 parts Aloe Vera Gel, 100 parts Sodium Chloride, 2 parts Matrine, 1 part Campanile, 1 part Vitamin, 1 part Wheat Germ Oil , sodium chloride and citric acid; wherein the amount of sodium chloride is such that the viscosity of the system at room temperature is 4000mPa·s, and the amount of citric acid is such that the pH of the system is 7. Other steps and parameters are the same as those in the first embodiment.

具体实施方式三:本实施方式的一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法按以下步骤进行:Specific Embodiment Three: A preparation method of a no-wash low-foaming bath product for space or diving environment according to this embodiment is carried out according to the following steps:

一、按质量份数称取180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、10~15份黄原胶、60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素E和1~2份小麦胚芽油,备用;1. Weigh 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, 40-50 parts of lecithin, 10-15 parts of xanthan gum, 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanolin, 1-2 parts of vitamin E and 1-2 parts of wheat germ oil, set aside;

二、将180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、 和10~15份黄原胶加入到反应容器中,然后将反应容器置于水浴中,由室温加热至温度为70~80℃,并在温度为70~80℃和搅拌速度为1500r/min~2000r/min的条件下搅拌15min~25min,然后转至均质机中进行均质混匀,均质时间为8min~12min,得到均质后混合物,将水浴温度由70~80℃降至温度为50~60℃,然后将均质后的混合物转至水浴中,再加入60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素E和1~2份小麦胚芽油,在温度为50~60℃和搅拌速度为1500r/min~2000r/min的条件下搅拌均匀,得到组合物,然后加入氯化钠调节体系黏度至组合物在室温下的黏度为4000mPa·s,最后加入柠檬酸调节体系pH值至6~7,得到产品组合物;2. Add 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, 40-50 parts of lecithin, and 10-15 parts of xanthan gum into the reaction vessel, and then place the reaction vessel In a water bath, heat from room temperature to a temperature of 70-80°C, and stir for 15min-25min at a temperature of 70-80°C and a stirring speed of 1500r/min-2000r/min, then transfer to a homogenizer for Homogeneous mixing, the homogenization time is 8min~12min, to obtain the homogenized mixture, lower the temperature of the water bath from 70~80℃ to 50~60℃, then transfer the homogenized mixture to the water bath, and then add 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanolin, 1-2 parts of vitamin E and 1-2 parts of wheat germ oil, at a temperature of 50-60 ° C and Stir evenly at a stirring speed of 1500r/min to 2000r/min to obtain a composition, then add sodium chloride to adjust the viscosity of the system until the viscosity of the composition at room temperature is 4000mPa·s, and finally add citric acid to adjust the pH value of the system to 6~7, obtain product composition;

三、用铝箔对步骤二得到的产品组合物进行密封包装,得到用于空间或潜水环境的免洗低泡沐浴产品。3. The product composition obtained in step 2 is sealed and packaged with aluminum foil to obtain a non-cleaning low-foaming bath product for space or diving environment.

具体实施方式四:本实施方式与具体实施方式三不同的是:步骤一中按质量份数称取由200份月桂酰谷氨酸钠、200份正癸基葡萄糖苷、50份卵磷脂、14份黄原胶、80份甘油、100份芦荟胶、2份苦参碱、1份甘宝素、1份维生素和1份小麦胚芽油,备用。其他步骤及参数与具体实施方式三相同。Specific embodiment four: the difference between this embodiment and specific embodiment three is: in step one, take by weight 200 parts of sodium lauroyl glutamate, 200 parts of n-decyl glucoside, 50 parts of lecithin, 14 1 part xanthan gum, 80 parts glycerin, 100 parts aloe vera gel, 2 parts matrine, 1 part campanolin, 1 part vitamin and 1 part wheat germ oil, set aside. Other steps and parameters are the same as those in the third embodiment.

具体实施方式五:本实施方式与具体实施方式三或四不同的是:步骤二中将反应容器置于水浴中,由室温加热至温度为75℃。其他步骤及参数与具体实施方式三或四相同。Embodiment 5: The difference between this embodiment and Embodiment 3 or 4 is that in step 2, the reaction vessel is placed in a water bath and heated from room temperature to 75°C. Other steps and parameters are the same as those in Embodiment 3 or 4.

具体实施方式六:本实施方式与具体实施方式三至五之一不同的是:步骤二中在温度为75℃和搅拌速度为2000r/min的条件下搅拌20min。其他步骤及参数与具体实施方式三至五之一相同。Embodiment 6: This embodiment is different from Embodiment 3 to Embodiment 5 in that: in step 2, the temperature is 75° C. and the stirring speed is 2000 r/min for 20 min. Other steps and parameters are the same as one of the third to fifth specific embodiments.

具体实施方式七:本实施方式与具体实施方式三至六之一不同的是:步骤二中转至均质机中进行均质混匀,均质时间为10min,得到均质后混合物。其他步骤及参数与具体实施方式三至六之一相同。Embodiment 7: This embodiment is different from Embodiment 3 to Embodiment 6 in that: step 2 is transferred to a homogenizer for homogeneous mixing, and the homogenization time is 10 minutes to obtain a homogenized mixture. Other steps and parameters are the same as one of the third to sixth specific embodiments.

具体实施方式八:本实施方式与具体实施方式三至七之一不同的是:步骤二中将水浴温度由70~80℃降至温度为55℃。其他步骤及参数与具体实施方式三至七之一相同。Embodiment 8: This embodiment differs from Embodiment 3 to Embodiment 7 in that: in step 2, the temperature of the water bath is lowered from 70 to 80°C to 55°C. Other steps and parameters are the same as one of the third to seventh specific embodiments.

试验一、本试验的一种用于空间或潜水环境的免洗低泡沐浴产品按质量份数由200份月桂酰谷氨酸钠、200份正癸基葡萄糖苷、50份卵磷脂、14份黄原胶、80份甘油、100份芦荟胶、2份苦参碱、1份甘宝素、1份维生素、1份小麦胚芽油、氯化钠和柠檬酸制备而成;其中氯化钠的量为使体系在室温下黏度为4000mPa·s,柠檬酸的量为使体系pH值为7。Test 1. A kind of disposable low-foam bath product used in space or diving environment in this test consists of 200 parts of sodium lauroyl glutamate, 200 parts of n-decyl glucoside, 50 parts of lecithin, 14 parts by mass Xanthan gum, 80 parts of glycerin, 100 parts of aloe vera gel, 2 parts of matrine, 1 part of campanolin, 1 part of vitamins, 1 part of wheat germ oil, sodium chloride and citric acid; wherein the amount of sodium chloride is The viscosity of the system at room temperature is 4000mPa·s, and the amount of citric acid is such that the pH value of the system is 7.

试验二、制备如试验一所述的一种用于空间或潜水环境的免洗低泡沐浴产品的方法按 以下步骤进行:Test two, the method for preparing a kind of disposable low-foam bath product for space or diving environment as described in test one is carried out according to the following steps:

一、按质量份数称取200份月桂酰谷氨酸钠、200份正癸基葡萄糖苷、50份卵磷脂、14份黄原胶、80份甘油、100份芦荟胶、2份苦参碱、1份甘宝素、1份维生素和1份小麦胚芽油,备用;1. Weigh 200 parts of sodium lauroyl glutamate, 200 parts of n-decyl glucoside, 50 parts of lecithin, 14 parts of xanthan gum, 80 parts of glycerin, 100 parts of aloe vera gel, 2 parts of matrine , 1 part of Campanola, 1 part of Vitamin and 1 part of Wheat Germ Oil, set aside;

二、将200份月桂酰谷氨酸钠、200份正癸基葡萄糖苷、50份卵磷脂、和14份黄原胶加入到反应容器中,然后将反应容器置于水浴中,由室温加热至温度为75℃,并在温度为75℃和搅拌速度为2000r/min的条件下搅拌20min,然后转至均质机中进行均质混匀,均质时间为10min,得到均质后混合物,将水浴温度由750℃降至温度为55℃,然后将均质后的混合物转至水浴中,再加入80份甘油、100份芦荟胶、2份苦参碱、1份甘宝素、1份维生素E和1份小麦胚芽油,在温度为55℃和搅拌速度为2000r/min的条件下搅拌均匀,得到组合物,然后加入氯化钠调节体系黏度至体系在室温下的黏度为4000mPa·s,最后加入柠檬酸调节体系pH值至7,得到产品组合物;Two, 200 parts of sodium lauroyl glutamate, 200 parts of n-decyl glucoside, 50 parts of lecithin, and 14 parts of xanthan gum are added to the reaction vessel, then the reaction vessel is placed in a water bath and heated from room temperature to The temperature is 75°C, and at a temperature of 75°C and a stirring speed of 2000r/min, it is stirred for 20min, then transferred to a homogenizer for homogeneous mixing, and the homogenization time is 10min to obtain a homogeneous mixture. The temperature of the water bath was lowered from 750°C to 55°C, and then the homogenized mixture was transferred to the water bath, and 80 parts of glycerin, 100 parts of aloe gel, 2 parts of matrine, 1 part of campanol, 1 part of vitamin E and 1 part of wheat germ oil was stirred evenly at a temperature of 55°C and a stirring speed of 2000r/min to obtain a composition, then sodium chloride was added to adjust the viscosity of the system until the viscosity of the system at room temperature was 4000mPa·s, and finally Citric acid adjusts the pH value of the system to 7 to obtain the product composition;

三、用铝箔对步骤二得到的产品组合物进行密封包装,得到用于空间或潜水环境的免洗低泡沐浴产品。3. The product composition obtained in step 2 is sealed and packaged with aluminum foil to obtain a non-cleaning low-foaming bath product for space or diving environment.

(一)试验二制备的用于空间或潜水环境的免洗低泡沐浴产品,其外观、气味、常规和极限条件稳定性检测(1) The appearance, smell, routine and limit condition stability test of the disposable low-foaming bath products used in space or diving environment prepared in test 2

1、实验方法如下:1. The experimental method is as follows:

①取5mL试验二制备的沐浴产品置于干净的烧杯中,观察其是否含有杂质、质地均一;①Put 5mL of the bath product prepared in Test 2 into a clean beaker, and observe whether it contains impurities and has a uniform texture;

②本产品未添加任何香精等物质,请若干名志愿者闻样品是否有异味;②This product does not add any essence and other substances, ask several volunteers to smell the sample for any peculiar smell;

③常规的稳定性测定主要是对其耐冷耐热性的检测,分别将样品置于-5℃、40℃和25℃下24h,与置于室温下样品进行比对,看其是否分层或者变化;③ The conventional stability test is mainly to test its cold and heat resistance. The samples are placed at -5°C, 40°C and 25°C for 24 hours, and compared with the samples at room temperature to see whether they are delaminated or not. Variety;

④在空间站中有可能经受极限条件的挑战,将样品分别在有光和无光条件下置于0℃和65℃各24h,重复放置三次后观察是否分层或变化。④ It is possible to withstand the challenge of extreme conditions in the space station. The samples were placed at 0°C and 65°C for 24 hours under light and dark conditions, respectively, and were placed three times to observe whether they were stratified or changed.

2、实验结果:见表1。2. Experimental results: See Table 1.

表1沐浴产品理化指标与检测结果Table 1 Physical and chemical indicators and test results of bath products

3、结论:根据国内浴液行业标准为指标,该款沐浴产品达到了浴液的行业标准。3. Conclusion: According to the domestic bath liquid industry standard as an indicator, this bath product has reached the industry standard of bath liquid.

(二)将试验二制备的沐浴产品作为空间站航天员的在轨洗浴用品,对其天然表面活性物质、天然抑菌剂、防腐剂少水条件下皮肤、粘膜刺激性检测,以确定化学品对哺乳动物皮肤局部是否有刺激作用及程度。(2) Use the bath products prepared in Test 2 as on-orbit bath products for astronauts on the space station, and test their natural surface active substances, natural antibacterial agents, preservatives, and skin and mucous membrane irritation under water-less conditions to determine the effects of chemicals on the skin and mucous membranes. Is there any irritation on mammalian skin and its degree?

1、实验方法:1. Experimental method:

①实验动物和饲养环境:大耳白色家兔,成年、健康、皮肤无损伤的动物,雌性和雄性各半。实验动物至少要用4只,实验动物应单笼饲养,试验前动物要在实验动物房环境中至少适应3d时间。实验动物及实验动物房符合国家相应规定。选用常规饲料,饮水不限制。①Experimental animals and breeding environment: big-eared white rabbits, adult, healthy animals with no skin damage, half female and half male. At least 4 experimental animals should be used, and the experimental animals should be kept in single cages. Before the experiment, the animals should adapt to the environment of the experimental animal room for at least 3 days. Experimental animals and experimental animal rooms comply with the corresponding national regulations. Conventional feed was used, and drinking water was not restricted.

②试验前约24h,将实验动物背部脊柱两侧毛剪掉,不可损伤表皮,去毛范围左、右各约2cm×3cm。②About 24 hours before the test, the hair on both sides of the back and spine of the experimental animals was cut off without damaging the epidermis.

③取受试物(试验二制备的沐浴产品)0.5mL,不需稀释,直接涂在皮肤上,每天涂抹1次,然后用二层纱布(2.5cm×2.5cm)和一层玻璃纸或类似物覆盖,再用无刺激性胶布和绷带加以固定。另一侧皮肤作为对照。采用封闭试验,敷用时间为2h,从第二天开始,每次涂抹前应剪毛,用水或无刺激性溶剂清除残留受试物。一小时后观察结果,连续涂抹14d,试验结束后用温水清除残留受试物。对照区和试验区同样处理。③Take 0.5mL of the test substance (the bath product prepared in Test 2) and apply it directly on the skin without dilution, once a day, and then use two layers of gauze (2.5cm×2.5cm) and a layer of cellophane or similar Cover and secure with non-irritant tape and bandages. The skin on the other side served as a control. The closed test is adopted, and the application time is 2 hours. From the next day, the hair should be sheared before each application, and the residual test substance should be removed with water or non-irritating solvent. Observe the result one hour later, apply it continuously for 14 days, and remove the residual test substance with warm water after the test. The control area and the test area were treated in the same way.

2结果:①于清除受试物后的1h、24h、48h和72h观察涂抹部位皮肤反应,得到如表2所示的皮肤刺激反应评分表,以受试动物积分的平均值进行综合评价,从而得到如表3所示的皮肤刺激反应积分表。2 Results: ① Observe the skin reaction at the application site at 1h, 24h, 48h and 72h after removing the test substance, and obtain the skin irritation reaction scoring table shown in Table 2, and conduct a comprehensive evaluation with the average value of the test animal points, so that Obtain the integral table of skin irritation reaction as shown in Table 3.

②于清除受试物后的24h、48h和72h各观察时点最高积分均值,得到如表4所示的判定皮肤刺激强度表。② The highest integral mean value at each observation time point of 24h, 48h and 72h after the test substance was removed, and the table for judging the intensity of skin irritation shown in Table 4 was obtained.

③取受试物(试验二制备的沐浴产品)直接涂在眼部,于清除受试物后的1h、24h、72h和7d观察涂抹部位皮肤反应,得到如表5所示的眼部刺激反应积分表。③ Take the test substance (the bath product prepared in Test 2) and apply it directly to the eyes, and observe the skin reaction at the application site 1h, 24h, 72h and 7d after the test substance is removed, and the eye irritation reaction shown in Table 5 is obtained point table.

按下列公式计算每天每只动物平均积分:Calculate the average score per animal per day according to the following formula:

表2皮肤刺激反应评分Table 2 Skin irritation score

表3皮肤刺激反应积分表Table 3 Score table of skin irritation reaction

注:*表示有一只日本大耳白兔出现红斑1级,积1分;Note: * indicates that there is a Japanese white rabbit with grade 1 erythema, and 1 point is accumulated;

表4皮肤刺激强度分级Table 4 Grading of skin irritation intensity

表5眼刺激反应积分(30s冲洗试验)Table 5 eye irritation reaction score (30s washing test)

注:表4中1.2.3.4.5.6分别代表市售沐浴露组、市售洗发液组、试验二配方组、卵磷脂组,芦荟胶组,苦参碱组Note: 1.2.3.4.5.6 in Table 4 represent the commercially available shower gel group, commercially available shampoo group, test 2 formula group, lecithin group, aloe vera gel group, and matrine group respectively

3、结论:试验样品对眼、皮肤无刺激。3. Conclusion: The test sample has no irritation to eyes and skin.

(三)一种用于空间站的免洗三合一沐浴产品理化性能研究(3) Research on the physical and chemical properties of a no-wash three-in-one bath product used in the space station

1、实验试剂与设备1. Experimental reagents and equipment

(1)菌株:本实验所采用的菌种均购自中国菌种保藏中心,共有3株细菌和1株酵母菌,菌种名称及AACC编号如表6所示。(1) Strains: The strains used in this experiment were all purchased from the China Culture Collection Center. There were 3 strains of bacteria and 1 strain of yeast. The strain names and AACC numbers are shown in Table 6.

表6:微生物污染测试用菌种Table 6: Bacteria for Microbial Contamination Test

菌种名称strain name 编号Numbering 大肠埃希氏菌Escherichia coli 87398739 金黄色葡萄球菌Staphylococcus aureus 65386538 铜绿假单胞菌Pseudomonas aeruginosa 90279027 白色假丝酵母菌Candida albicans 10231 10231

(2)培养基及试剂(2) Medium and reagents

本实验所使用的培养基均购自Oxoid,包括Tween 80,SCDLP 80肉汤,SCDLP 20肉汤,胰蛋白胨-氯化钠溶液(稀释液),MCA,BPA,CET,SDCA,TSA,SDA。The medium used in this experiment was purchased from Oxoid, including Tween 80, SCDLP 80 broth, SCDLP 20 broth, tryptone-sodium chloride solution (diluted solution), MCA, BPA, CET, SDCA, TSA, SDA.

(3)仪器设备(3) Instruments and equipment

本实验用到的仪器设备有:Thermo型号为815的培养箱;Thermo型号为2868的水浴锅;Seward型号为400的拍打仪;梅特勒型号为PB3002的托盘天平;Fisher的 旋涡混合器。The instruments and equipment used in this experiment are: Thermo incubator model 815; Thermo model 2868 water bath; Seward model 400 beater; Mettler model PB3002 tray balance; Fisher vortex mixer.

2、静态流淌性实验方法:2. Static fluidity test method:

A在不同温度下的黏度测定方法:A Viscosity measurement method at different temperatures:

(1)45℃黏度值:样品装入玻璃烧杯内,将其放置在45℃的恒温培养箱中保温24h,取出后立即测试黏度值。(1) Viscosity value at 45°C: Put the sample into a glass beaker, place it in a constant temperature incubator at 45°C for 24 hours, and test the viscosity value immediately after taking it out.

(2)30℃黏度值:样品装入玻璃烧杯内,放置在30℃的恒温培养箱中保温24h,取出后立即测试黏度值。(2) Viscosity value at 30°C: Put the sample into a glass beaker, place it in a constant temperature incubator at 30°C for 24 hours, and test the viscosity value immediately after taking it out.

(3)2℃黏度值:样品装入玻璃烧杯内,将其放置在2℃的冰箱中,保存24h,取出后立即测试黏度值。从流体力学的角度而言,黏度是流体的一种动态流变性能,是衡量流体性能的重要指标之一。(3) Viscosity value at 2°C: put the sample into a glass beaker, place it in a refrigerator at 2°C, store it for 24 hours, and test the viscosity value immediately after taking it out. From the perspective of fluid mechanics, viscosity is a dynamic rheological property of fluid and one of the important indicators to measure fluid performance.

黏度稳定对于洗浴用品的品质控制是必不可少的指标。然而单用黏度数值不足以全面反映香波的应用特性,静态流淌性在一定程度上对于消费者使用而言显得更为重要和实用。静态流淌速度太低则表明不易将洗浴用品从包装瓶倒出,而太高则易过量使用。流淌性的快慢表明洗浴用品是否易被消费者使用,并可能影响其品牌形象和再次购买时的心理接受程度。Viscosity stability is an essential indicator for the quality control of toiletries. However, the viscosity value alone is not enough to fully reflect the application characteristics of the shampoo, and the static fluidity is more important and practical for consumers to use to a certain extent. A static flow rate that is too low indicates poor pouring of the toiletries from the bottle, while too high a tendency to overuse. The speed of fluidity indicates whether the bath product is easy to be used by consumers, and may affect its brand image and psychological acceptance when repurchasing.

B准确称量10g(精确0.1)样品于聚乙烯管中(内径15mm、长度300mm、内壁光洁、无毛刺等缺陷,其中一端封口),各3份。封口后分别垂直固定放在2℃的冰箱和25℃、45℃的恒温培养箱内保存24h。取出保存样品(环境温度为16℃),将管口朝下固定在30°的斜坡上,立即计时至样品流到管口的时间为流淌时间(s)。B Accurately weigh 10g (accurately 0.1) of the sample into a polyethylene tube (with an inner diameter of 15mm, a length of 300mm, a smooth inner wall, no defects such as burrs, and one end is sealed), 3 parts each. After sealing, they were fixed vertically and stored in a refrigerator at 2°C and a constant temperature incubator at 25°C and 45°C for 24 hours. Take out the preserved sample (the ambient temperature is 16°C), fix the mouth of the tube downward on a slope of 30°, and immediately count the time until the sample flows to the mouth of the tube as the flow time (s).

C得到如表7所示的静态流淌实验结果。C obtained the static flow test results shown in Table 7.

表7空间站三合一样品与市售样品的静态流淌实验结果Table 7 Static flow test results of the space station three-in-one sample and commercially available samples

3、微生物污染测试3. Microbial contamination test

A好氧菌的计数和检测A count and detection of aerobic bacteria

本实验通过增菌法对化妆品中的好氧菌落总数进行检测,检测方法参考ISO21149, 化妆品中好氧菌落总数的检测及计数。In this experiment, the total number of aerobic colonies in cosmetics is detected by the enrichment method. The detection method refers to ISO21149, the detection and counting of the total number of aerobic colonies in cosmetics.

称取1克样品到含有一定量增溶剂(Tween 80)的无菌袋中,再加入9克的稀释液(SCDLP80肉汤),混合均匀后在32.5±2.5℃培养箱中培养至少20小时(最多72小时)后,转移0.1毫升培养好的肉汤到倒有15ml的选择性培养基(TSA)的表面,将平板在35±1℃培养48小时到72小时。观察琼脂表面是否有菌生长,如有生长则需对其进行计数。Weigh 1 gram of sample into a sterile bag containing a certain amount of solubilizer (Tween 80), then add 9 grams of diluent (SCDLP80 broth), mix well and incubate in an incubator at 32.5±2.5°C for at least 20 hours ( After a maximum of 72 hours), transfer 0.1 ml of cultured broth onto the surface poured with 15 ml of selective medium (TSA), and incubate the plate at 35±1° C. for 48 hours to 72 hours. Observe whether there is bacterial growth on the surface of the agar, and count it if there is growth.

B洗浴产品中霉菌及酵母菌的检测B. Detection of mold and yeast in bath products

本实验通过平板计数法对化妆品中霉菌及酵母菌进行检测,检测方法参考ISO16212,化妆品中霉菌及酵母菌的计数。In this experiment, the mold and yeast in cosmetics are detected by plate counting method. The detection method refers to ISO16212, the counting of mold and yeast in cosmetics.

称取1克样品到含有一定量增溶剂(Tween 80)的无菌袋中,再加入9克的稀释液(SCDLP20肉汤),混合均匀后转移1mL的样品稀释液到倒有15mL的SDCA培养基中,混合均匀,并使培养基凝固。再将平板倒置后放入25℃±2.5℃的培养箱培养3到5天。培养之后进对菌落数在15到150之间的平板进行计数。Weigh 1 gram of sample into a sterile bag containing a certain amount of solubilizer (Tween 80), then add 9 grams of diluent (SCDLP20 broth), mix well and transfer 1 mL of sample diluent to 15 mL of SDCA for incubation medium, mix well, and allow the medium to solidify. Then put the plate upside down and put it into an incubator at 25°C±2.5°C for 3 to 5 days. After incubation, count the plates with 15 to 150 colonies.

C洗浴产品中致病菌的检测C Detection of pathogenic bacteria in bath products

本实验参考ISO的方法,对样品中的大肠埃希氏菌、金黄色葡萄球菌、铜绿假单胞菌、白色假丝酵母菌进行了检测。其中大肠埃希氏菌的检测方法参考ISO21150,金黄色葡萄球菌的检测方法参考ISO22718,铜绿假单胞菌的检测方法参考ISO22717,白色假丝酵母菌的检测方法参考ISO18416。In this experiment, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans in the samples were detected with reference to the ISO method. The detection method of Escherichia coli refers to ISO21150, the detection method of Staphylococcus aureus refers to ISO22718, the detection method of Pseudomonas aeruginosa refers to ISO22717, and the detection method of Candida albicans refers to ISO18416.

用无菌接种环将培养好的增菌液用平板划线的方法接到相应的选择性培养基的表面,以得到单个的菌落。然后将平板倒置放入32.5±2.5℃培养箱中培养24-48小时。同时要做培养基的阴性与阳性对照。阳性对照即用平板划线的方法将AACC的大肠埃希氏菌株、金黄色葡萄球菌株、铜绿假单胞菌株、白色假丝酵母菌株接到相应的选择性培养基的表面,与样品一起培养,各菌株典型的菌落特征如表8所列,如符合则说明所用培养基没有问题。阴性对照即不接样品,直接培养培养基,看是否存在环境污染。Use a sterile inoculation loop to connect the cultured enrichment solution to the surface of the corresponding selective medium by streaking on a plate to obtain a single colony. Then place the plate upside down and place it in an incubator at 32.5±2.5° C. for 24-48 hours. At the same time, the negative and positive controls of the culture medium should be done. The positive control is to connect the Escherichia coli strain, Staphylococcus aureus strain, Pseudomonas aeruginosa strain, and Candida albicans strain of AACC to the surface of the corresponding selective medium by the method of streaking on the plate, and cultivate together with the sample , the typical colony characteristics of each bacterial strain are listed in Table 8, if they match, it means that there is no problem with the medium used. In the negative control, the samples were not connected, and the medium was cultured directly to see if there was any environmental pollution.

表8菌种在选择性培养基上的菌落特征The colony characteristics of table 8 strains on the selective medium

4、防腐剂效力测试4. Preservative effectiveness test

本实验参考USP 51的测试方法。首先需要将AACC菌种进行活化,将细菌的菌种接到TSA平板上,在32℃培养3天,将霉菌和酵母菌的菌种接到SDA平板上,在25℃培养5天。培养好后,用无菌接种环将细菌和酵母菌刮取到无菌的9g/L的氯化钠溶液中,霉菌刮取到添加了0.05%聚山梨醇酯的9g/L氯化钠溶液中。将细菌的浓度稀释到10-6~10-9,霉菌酵母菌的浓度稀释到10-5~10-8,用平板计数法来确认菌液浓度。再往20g样品中加入不超过0.2mL的该菌液,使最终样品中的菌液的浓度在105~106cfu/mL之间。需要对样品中菌液浓度0接触时间的值进行测定,如果其值<10cfu/g,那么必须对产品进行增菌培养,如果增菌后其值仍<10cfu/g,需要往样品中加一定量的中和液来中和产品中的抗菌剂来进行防腐效力的挑战测试。This experiment refers to the test method of USP 51. First, the AACC strains need to be activated, the bacterial strains are connected to the TSA plate, and cultured at 32°C for 3 days, the mold and yeast strains are connected to the SDA plate, and cultured at 25°C for 5 days. After culturing, use a sterile inoculation loop to scrape bacteria and yeast into a sterile 9g/L sodium chloride solution, and scrape mold into a 9g/L sodium chloride solution added with 0.05% polysorbate middle. Dilute the concentration of bacteria to 10 -6 ~ 10 -9 , and the concentration of mold and yeast to 10 -5 ~ 10 -8 , and confirm the concentration of bacteria solution by plate counting method. Then add no more than 0.2 mL of the bacterial solution to the 20 g sample, so that the concentration of the bacterial solution in the final sample is between 10 5 and 10 6 cfu/mL. It is necessary to measure the value of the contact time of the concentration of bacteria in the sample. If the value is <10cfu/g, then the product must be enriched for culture. If the value is still <10cfu/g after enrichment, it is necessary to add a certain amount to the sample A certain amount of neutralizing solution is used to neutralize the antimicrobial agent in the product to conduct the challenge test of preservative efficacy.

接种了菌液的样品在分别培养14天和28天后(细菌在32℃培养,霉菌和酵母菌在25℃培养),用平板计数法确定其样品中的菌液浓度,如果细菌从最初到培养了14天后,其菌落数的减少不低于2.0Log,并且从第14天到28天菌落数没有增长(即菌落数没有增加0.5Log)。霉菌酵母菌从最初到第14天及28天都没有增长(即菌落数没有增加0.5Log)。则说明该样品的防腐体系是有效的。After the samples inoculated with the bacterial liquid were cultured for 14 days and 28 days respectively (the bacteria were cultured at 32°C, and the mold and yeast were cultured at 25°C), the concentration of the bacterial liquid in the sample was determined by the plate counting method. After 14 days, the reduction of its bacterial colony number was not less than 2.0Log, and from the 14th day to the 28th day, the bacterial colony number did not increase (that is, the bacterial colony number did not increase by 0.5Log). There was no growth of mold yeast from the beginning to the 14th day and 28th day (that is, the number of colonies did not increase by 0.5 Log). Then it shows that the anticorrosion system of this sample is effective.

结果:得到如表9所示的初始时间微生物检测结果表和如表10所示的样品防腐体系抗菌效力的有效性表(加速老化)Result: obtain the initial time microbial detection result table as shown in table 9 and the effectiveness table (accelerated aging) of the sample antiseptic system antibacterial efficacy as shown in table 10

表9所示的初始时间微生物检测结果表The initial time microbial detection result table shown in table 9

表10:样品防腐体系抗菌效力的有效性(加速老化)Table 10: Effectiveness of Antimicrobial Efficacy of Sample Preservative Systems (Accelerated Aging)

Claims (8)

1.一种用于空间或潜水环境的免洗低泡沐浴产品,其特征在于该产品按质量份数由180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、10~15份黄原胶、60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素、1~2份小麦胚芽油、氯化钠和柠檬酸制备而成;其中氯化钠的量为使体系在室温下黏度为4000mPa·s,柠檬酸的量为使体系pH值为6~7。1. A wash-free low-foam bath product for space or diving environment, characterized in that the product consists of 180 to 200 parts of sodium lauroyl glutamate, 180 to 200 parts of n-decyl glucoside, 40 parts by mass ~50 parts of lecithin, 10~15 parts of xanthan gum, 60~80 parts of glycerin, 80~100 parts of aloe vera gel, 1~4 parts of matrine, 1~2 parts of campanolin, 1~2 parts of vitamins, 1~2 parts It is prepared from wheat germ oil, sodium chloride and citric acid; the amount of sodium chloride is such that the viscosity of the system at room temperature is 4000mPa·s, and the amount of citric acid is such that the pH of the system is 6-7. 2.根据权利要求1所述的一种用于空间或潜水环境的免洗低泡沐浴产品,其特征在于所述的用于空间或潜水环境的免洗低泡沐浴产品按质量份数由200份月桂酰谷氨酸钠、200份正癸基葡萄糖苷、50份卵磷脂、14份黄原胶、80份甘油、100份芦荟胶、2份苦参碱、1份甘宝素、1份维生素、1份小麦胚芽油、氯化钠和柠檬酸制备而成;其中氯化钠的量为使体系在室温下黏度为4000mPa·s,柠檬酸的量为使体系pH值为7。2. A kind of disposable low-foam bath product for space or diving environment according to claim 1, characterized in that said disposable low-foam bath product for space or diving environment consists of 200 parts by mass Sodium lauroyl glutamate, 200 parts of n-decyl glucoside, 50 parts of lecithin, 14 parts of xanthan gum, 80 parts of glycerin, 100 parts of aloe vera gel, 2 parts of matrine, 1 part of campanola, 1 part of vitamins, Prepared from 1 part of wheat germ oil, sodium chloride and citric acid; wherein the amount of sodium chloride is such that the viscosity of the system at room temperature is 4000 mPa·s, and the amount of citric acid is such that the pH of the system is 7. 3.一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法,其特征在于该方法按以下步骤进行:3. A preparation method for a wash-free low-foam bath product for space or diving environment, characterized in that the method is carried out in the following steps: 一、按质量份数称取180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、10~15份黄原胶、60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素E和1~2份小麦胚芽油,备用;1. Weigh 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, 40-50 parts of lecithin, 10-15 parts of xanthan gum, 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanolin, 1-2 parts of vitamin E and 1-2 parts of wheat germ oil, set aside; 二、将180~200份月桂酰谷氨酸钠、180~200份正癸基葡萄糖苷、40~50份卵磷脂、和10~15份黄原胶加入到反应容器中,然后将反应容器置于水浴中,由室温加热至温度为70~80℃,并在温度为70~80℃和搅拌速度为1500r/min~2000r/min的条件下搅拌15min~25min,然后转至均质机中进行均质混匀,均质时间为8min~12min,得到均质后混合物,将水浴温度由70~80℃降至温度为50~60℃,然后将均质后的混合物转至水浴中,再加入60~80份甘油、80~100份芦荟胶、1~4份苦参碱、1~2份甘宝素、1~2份维生素E和1~2份小麦胚芽油,在温度为50~60℃和搅拌速度为1500r/min~2000r/min的条件下搅拌均匀,得到组合物,然后加入氯化钠调节组合物黏度至组合物在室温下的黏度为4000mPa·s,最后加入柠檬酸调节组合物pH值至6~7,得到产品组合物;2. Add 180-200 parts of sodium lauroyl glutamate, 180-200 parts of n-decyl glucoside, 40-50 parts of lecithin, and 10-15 parts of xanthan gum into the reaction vessel, and then place the reaction vessel In a water bath, heat from room temperature to a temperature of 70-80°C, and stir for 15min-25min at a temperature of 70-80°C and a stirring speed of 1500r/min-2000r/min, then transfer to a homogenizer for Homogeneous mixing, the homogenization time is 8min~12min, to obtain the homogenized mixture, lower the temperature of the water bath from 70~80℃ to 50~60℃, then transfer the homogenized mixture to the water bath, and then add 60-80 parts of glycerin, 80-100 parts of aloe vera gel, 1-4 parts of matrine, 1-2 parts of campanolin, 1-2 parts of vitamin E and 1-2 parts of wheat germ oil, at a temperature of 50-60 ° C and Stir evenly at a stirring speed of 1500r/min-2000r/min to obtain a composition, then add sodium chloride to adjust the viscosity of the composition until the viscosity of the composition at room temperature is 4000mPa·s, and finally add citric acid to adjust the pH of the composition value to 6-7 to obtain the product composition; 三、用铝箔对步骤二得到的产品组合物进行密封包装,得到用于空间或潜水环境的免洗低泡沐浴产品。3. The product composition obtained in step 2 is sealed and packaged with aluminum foil to obtain a non-cleaning low-foaming bath product for space or diving environment. 4.根据权利要求3所述的一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法,其特征在于步骤一中按质量份数称取由200份月桂酰谷氨酸钠、200份正癸基葡萄糖苷、50份卵磷脂、14份黄原胶、80份甘油、100份芦荟胶、2份苦参碱、1份甘宝素、1份维生素和1份小麦胚芽油,备用。4. the preparation method of a kind of disposable low-foaming bath product that is used for space or diving environment according to claim 3, it is characterized in that in the step 1, take by weighing 200 parts of sodium lauroyl glutamate, 200 parts of n-decyl glucoside, 50 parts of lecithin, 14 parts of xanthan gum, 80 parts of glycerin, 100 parts of aloe vera gel, 2 parts of matrine, 1 part of campanola, 1 part of vitamins and 1 part of wheat germ oil, set aside. 5.根据权利要求3所述的一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法,其特征在于步骤二中将反应容器置于水浴中,由室温加热至温度为75℃。5. A method for preparing a no-clean low-foam bath product for use in space or diving environments according to claim 3, characterized in that in step 2, the reaction vessel is placed in a water bath and heated from room temperature to 75°C . 6.根据权利要求3所述的一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法,其特征在于步骤二中在温度为75℃和搅拌速度为2000r/min的条件下搅拌20min。6. A method for preparing a no-clean low-foam bath product for space or diving environment according to claim 3, characterized in that in step 2, the temperature is 75°C and the stirring speed is 2000r/min. 20min. 7.根据权利要求3所述的一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法,其特征在于步骤二中转至均质机中进行均质混匀,均质时间为10min,得到均质后混合物。7. A method for preparing a no-clean low-foam bath product for use in space or diving environments according to claim 3, characterized in that step 2 is transferred to a homogenizer for homogeneous mixing, and the homogenization time is 10 minutes , to obtain a homogeneous mixture. 8.根据权利要求3所述的一种用于空间或潜水环境的免洗低泡沐浴产品的制备方法,其特征在于步骤二中将水浴温度由70~80℃降至温度为55℃。8. A method for preparing a no-clean low-foaming bath product for space or diving environments according to claim 3, characterized in that in step 2, the temperature of the water bath is lowered from 70 to 80°C to 55°C.
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